JP2016159093A - Method for manufacturing lens capsule expansion device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a new method for manufacturing a lens capsule expansion device.SOLUTION: A method for manufacturing a lens capsule expansion device includes the steps as follows: a step of forming a core C of the lens capsule expansion device with an alkali-soluble resin; a step of making an inner mold 6 by the core C, making mold matching between the inner mold 6 and the split molds 7a, 7b of the lens capsule expansion device, and thereby forming a clearance space S between the split molds 7a, 7b and the inner mold 6; a step of injecting an alkali resistance resin melted at the temperature lower than a melting point of the alkali-soluble resin in the clearance space S; a step of forming the core and a complex 9 comprising the alkali resistance resin by cooling the split molds 7a, 7b and solidifying the alkali resistance resin; a step of deteriorating the core C by applying a physical external force to the complex 9; and a step of immersing the complex 9 in an alkaline solution L to elute the core C.SELECTED DRAWING: Figure 7

Description

  The present invention relates to a method for manufacturing a capsular bag expansion device that is installed in a capsular bag that has been incised in the anterior capsule in cataract surgery or the like.

  Conventionally, as shown in FIGS. 19 to 22, there are lens capsule expansion devices installed in a lens capsule that has been incised in the anterior capsule in cataract surgery or the like (Patent Document 1).

  The capsular bag expansion device shown in FIGS. 19 and 20 includes a front support portion 31 located on the front side in the lens capsule, a rear support portion 32 located on the rear side in the lens capsule, a front support portion 31 and a rear support portion. And a plurality of connecting portions 33 that connect 32 to each other.

  As shown in the drawing, the front support portion 31 is an elastic member formed in an annular shape having an opening 31a at the center. Similar to the front support portion 31, the rear support portion 32 is an elastic member formed in an annular shape having an opening 32a at the center, and is arranged in a manner facing in parallel on the rear side of the front support portion 31. . The connecting portion 33 is composed of four connecting pieces 33 a provided at a balanced interval in the circumferential direction of the front support portion 31 and the rear support portion 32.

  The lens capsule expansion device shown in FIGS. 21 and 22 includes a front support portion 41, a rear support portion 42, and a connection portion 43 similar to those of the lens capsule expansion device. Four second connecting portions 44 that connect the front support portion 41 and the rear support portion 42 are provided at positions.

  The second connecting portions 44 are arranged at equal intervals along the circumferential direction of the capsular bag expansion device, and both have an urging force in a direction in which the front support portion 41 and the rear support portion 42 are separated from each other. .

Japanese Patent No. 5594798

  The conventional lens capsule expanding device is manufactured using a biocompatible resin that has transparency, flexibility, elasticity, is chemically stable, and is physiologically inert.

  This capsular bag expansion device is formed on the basis of a general lens having a diameter of about 9 to 10 mm and a thickness of about 4 to 5 mm. The diameter of the outer peripheral edge of the front support portions 31 and 41 is 7. 0 mm, the diameter of the openings 31a and 41a is 5.0 mm, the width is 1.2 mm, the thickness is 0.15 to 0.4 mm, the diameter of the outer peripheral edge of the rear support parts 32 and 42 is 7.0 mm, and the opening The portions 32a and 42a have a diameter of 4.5 mm, a width of 1.5 mm, and a thickness of 0.2 to 0.5 mm.

  Such a conventional capsular bag expansion device is complicated in shape, and is extremely fine and extremely lightweight, and thus is extremely difficult to manufacture by the conventional resin molding method.

  Therefore, the present invention has been made for the purpose of providing a novel method for manufacturing a capsular bag expansion device that has such a complicated shape and is ultrafine and ultralight.

  Therefore, the present invention includes a front support portion located on the front side in the lens capsule, a rear support portion located on the rear side in the lens capsule, and a connecting portion that connects the front support portion and the rear support portion. The support portion is an elastic member formed in an annular shape having an opening in the center, the rear support portion is an elastic member formed in an annular shape having an opening in the center, and the connecting portion is a front support portion and a rear support portion. A method for manufacturing a capsular bag expansion device as an elastic member comprising a plurality of connecting pieces spaced apart from each other in the circumferential direction of the capsular bag, wherein (a) the core of the capsular bag expansion device is formed of an alkali-soluble resin (B) The core body is used as an inner mold, the inner mold is matched with the split mold of the lens capsule expansion device, and a gap space is formed between the split mold and the inner mold. (C) the gap A step of injecting an alkali-resistant resin melted at a temperature lower than the melting point of the alkali-soluble resin in between, (d) consisting of a core and an alkali-resistant resin by cooling the split mold and solidifying the alkali-resistant resin Forming a composite; (e) applying a physical external force to the composite to degrade the core; and (f) immersing the composite in an alkaline solution to elute the core. Each process is provided.

  And this invention shall be equipped with the 2nd connection part which connects a front support part and a back support part to the position of the diameter direction outer side of the said connection part at the lens capsule expansion | extension device, and this 2nd connection. The part is an elastic member composed of a plurality of connection pieces provided between the connection pieces of the connection part at intervals in the circumferential direction of the front support part and the rear support part.

  Furthermore, according to the present invention, the outer shape of each of the front support portion, the rear support portion, and the connecting portion is formed by a split mold, and the external shape of the second connecting portion is slidably inserted into the split mold. Formed by a child.

  Since the manufacturing method of the present invention is configured as described above, even if the lens capsule expansion device has a complicated shape and is ultra-fine and ultra-light, it can be easily manufactured and is mass-produced. It will also be possible.

It is a perspective view which shows an example of the capsular bag expansion device manufactured by this invention. FIG. 2 is a side view of the lens capsule expanding device shown in FIG. 1. FIG. 2 is a cross-sectional view of the lens capsule expanding device shown in FIG. 1. It is a side view of the core which modeled the internal shape of the capsular bag expansion device shown in FIG. It is a horizontal sectional view of the metal mold | die which manufactures the core shown in FIG. It is a horizontal sectional view of the metal mold | die for manufacturing the lens capsule expansion device shown in FIG. It is the schematic of the 2nd-4th process which manufactures the lens capsule expansion device shown in FIG. It is the schematic of the 5th process of manufacturing the capsular bag expansion device shown in FIG. It is the schematic of the 6th process which manufactures the capsular bag expansion device shown in FIG. It is a perspective view which shows the other example of the lens capsule expansion device manufactured by this invention. It is a side view of the lens capsule expansion device shown in FIG. FIG. 11 is a cross-sectional view of the lens capsule expanding device shown in FIG. 10. It is a side view of the core which modeled the internal shape of the capsular bag expansion device shown in FIG. It is a horizontal sectional view of the metal mold | die which manufactures the core shown in FIG. It is a horizontal sectional view of the metal mold | die for manufacturing the lens capsule expansion device shown in FIG. It is the schematic of the 2nd-4th process which manufactures the lens capsule expansion device shown in FIG. It is the schematic of the 5th process of manufacturing the capsular bag expansion device shown in FIG. It is the schematic of the 6th process of manufacturing the capsular bag expansion device shown in FIG. It is a perspective view which shows an example of the conventional capsular bag expansion device. FIG. 20 is a cross-sectional view of the conventional lens capsule expansion device shown in FIG. 19. It is a side view which shows the other example of the conventional capsular bag expansion device. It is a top view of the conventional lens capsule expansion device shown in FIG.

  Hereinafter, the manufacturing method of the lens capsule expansion device of the present invention will be described in detail based on the drawings.

  1 to 3 show an example of a lens capsule expansion device manufactured by the manufacturing method of the present invention. This lens capsule expansion device is installed in the lens capsule in which the anterior capsule is opened in cataract surgery, etc., has transparency, flexibility, elasticity, is chemically stable and physiologically inactive A biocompatible resin, particularly manufactured using an alkali resistant resin. Such synthetic resins include polyvinyl chloride (PVC), polyvinylidene chloride (PVDC), polyethylene (PE), polyethylene terephthalate (PET), polypropylene (PP), polystyrene (PS), polyvinylidene fluoride (PVDF), ABS resin, modified silicon resin, and the like can be used.

  The melting temperature of the alkali-resistant resin forming the lens capsule expansion device is set to a temperature lower than the melting temperature of the alkali-soluble resin forming the core C of the lens capsule expansion device described later.

  The capsular bag expansion device is similar to that shown in Patent Document 1, the front support portion 1 located on the front side in the lens capsule, the rear support portion 2 located on the rear side in the lens capsule, and the front support portion. 1 and a plurality of connecting portions 3 for connecting the rear support portion 2 to each other.

  The said front support part 1 is made into the elastic member formed in the cyclic | annular form which has the opening part 1a in the center. In addition, although this front support part 1 is horizontal in what is shown in the drawing, it moves from the radially inner end to the radially outer end in accordance with the inclination angle of the inner surface of the anterior capsule of the crystalline lens capsule. You may form so that it may incline below gradually. Moreover, you may form the front support part 1 so that thickness may become thin gradually toward radial outer side from radial inner side.

  Similar to the front support portion 1, the rear support portion 2 is an elastic member formed in an annular shape having an opening 2 a at the center, and is arranged in a manner facing in parallel on the rear side of the front support portion 1. . The posterior support portion 2 is also horizontal in the illustrated case, but as it goes from the radially inner end to the radially outer end in accordance with the inclination angle of the posterior capsule inner surface of the lens capsule. You may form so that it may incline gradually upwards. Moreover, you may form the back support part 2 so that thickness may become thin gradually toward radial outer side from radial inner side.

  The connecting portion 3 is an elastic member composed of four connecting pieces 3 a provided at a balanced interval in the circumferential direction of the front support portion 1 and the rear support portion 2. Note that a plurality of the connecting pieces 3a may be provided, and the number is not limited to four. Further, the connecting portion 3 is previously formed with a bent portion 4 for bending the connecting piece 3a in such a manner that it extends outward in the radial direction of the front support portion 1 and the rear support portion 2. In addition, the connecting portion 3 is provided at a position where the bent portion 4 is closer to the rear support portion 2 than the front support portion 1 in the connection piece 3a, but is provided at an intermediate position between the front support portion 1 and the rear support portion 2. In some cases, it may be provided at a position closer to the front support portion 1 than to the rear support portion 2.

  The capsular bag expansion device has a diameter of the outer peripheral edge of the front support portion 1 of 7.0 mm, a diameter of the opening 1a of 5.0 mm, and a width of 1.2 mm, as shown in Patent Document 1. The thickness of the rear support portion 2 is 7.0 mm, the diameter of the opening 2 a is 4.5 mm, the width is 1.5 mm, and the thickness is 0.1 mm. It is formed to 2 to 0.5 mm.

  The lens capsule expanding device configured as described above is manufactured through the following steps.

  First, in order to manufacture the capsular bag expansion device shown in FIGS. 1 to 3, as a first step, as shown in FIG. 4, a core C shaped like the inner shape of the capsular bag expansion device is formed by injection molding. , Formed with an alkali-soluble resin.

  As shown in FIG. 5, the core C is formed by fitting molds 5a and 5b shaped like the inner shape of the capsular bag expansion device, and into the hollow portions Sa and Sb of these molds 5a and 5b. It is formed by pouring molten alkali-soluble resin through a runner (not shown), and solidifying by cooling.

  As the alkali-soluble resin, a polyglycolic acid resin or the like can be used, but there is no particular limitation as long as it is a resin soluble in alkali. Furthermore, the alkali-soluble resin is preferably a plastically deformable resin or a resin that is easily plastically deformed. The melting temperature of the alkali-soluble resin is set to a temperature higher than the melting temperature of the alkali-resistant resin that forms the lens capsule expansion device.

  As the second step, as shown in FIG. 6 and FIG. 7 (1), the core C is an inner mold 6 and the inner mold 6 and a split mold that forms the outer shape of the lens capsule expansion device. 7a and 7b are mold-matched, and a gap space S is formed between the split molds 7a and 7b and the inner mold 6.

  As a third step, as shown in FIG. 7 (2), an alkali-resistant resin melted at a temperature lower than the melting point of the alkali-soluble resin is poured into the gap space S through the runner 8.

  As a fourth step, the split molds 7a and 7b are cooled to solidify the alkali-resistant resin to form a composite body 9 composed of a core body and an alkali-resistant resin, as shown in FIG. The mold is opened and the composite 9 is taken out from the split molds 7a and 7b.

  As a fifth step, a physical external force such as applying vibration, striking, or dropping is applied to the composite 9, and as shown in FIG. Deteriorate by breaking or crushing.

  As a sixth step, as shown in FIG. 9, the deteriorated composite 9 is immersed in an alkaline solution L to elute the alkali-soluble resin of the core C.

  Examples of the alkaline solution L for eluting the alkali-soluble resin of the core C include a sodium hydroxide aqueous solution and a sodium hydroxide aqueous solution.

  Thereafter, the lens capsule expanding device from which the core C has been eluted is pulled up from the alkaline solution L, washed with purified water, and then dried to obtain a finished lens capsule expanding device according to the present manufacturing method.

  10 to 12 show another example of the lens capsule expansion device manufactured by the manufacturing method of the present invention. This lens capsule expansion device is installed in the lens capsule in which the anterior capsule is opened in cataract surgery, etc., has transparency, flexibility, elasticity, is chemically stable and physiologically inactive A biocompatible resin, particularly manufactured using an alkali resistant resin. Such synthetic resins include polyvinyl chloride (PVC), polyvinylidene chloride (PVDC), polyethylene (PE), polyethylene terephthalate (PET), polypropylene (PP), polystyrene (PS), polyvinylidene fluoride (PVDF), ABS resin, modified silicon resin, and the like can be used.

  The melting temperature of the alkali-resistant resin forming the lens capsule expansion device is set to a temperature lower than the melting temperature of the alkali-soluble resin forming the core C of the lens capsule expansion device described later.

  The capsular bag expansion device has a plurality of front support portions 11 positioned on the front side in the lens capsule, a rear support portion 12 positioned on the rear side in the lens capsule, and a plurality of front support portions 11 and the rear support portions 12. A connecting portion 13 and a plurality of second connecting portions 14 that connect the front support portion 11 and the rear support portion 12 are provided at positions radially outside the connecting portion 13.

  The front support portion 11 is an elastic member formed in an annular shape having an opening 11a at the center. In the illustrated example, the front support portion 11 is gradually inclined downwardly from the radially inner end portion toward the radially outer end portion in accordance with the inclination angle of the anterior capsule inner surface of the crystalline lens capsule. However, it may be formed horizontally. Moreover, you may form the front support part 11 so that thickness may become thin gradually toward radial outer side from radial inner side.

  Like the front support portion 11, the rear support portion 12 is an elastic member formed in an annular shape having an opening 12 a at the center, and is disposed on the rear side of the front support portion 11. In addition, in the illustrated case, the posterior support portion 12 is also gradually inclined upward from the radially inner end to the radially outer end in accordance with the inclination angle of the posterior capsule inner surface of the lens capsule. However, it may be formed horizontally. Moreover, you may form the back support part 12 so that thickness may become thin gradually toward radial outer side from radial inner side.

  The connecting portion 13 is an elastic member composed of eight connecting pieces 13 a provided at a balanced interval in the circumferential direction of the front support portion 11 and the rear support portion 12. Note that a plurality of the connecting pieces 13a may be provided, and the number is not limited to eight. Further, the connecting portion 13 is previously formed with a bent portion 15 for bending the connecting piece 13a in such a manner that it extends outward in the radial direction of the front support portion 11 and the rear support portion 12. Further, the connecting portion 13 is provided at a position where the bent portion 15 is closer to the rear support portion 12 than the front support portion 1 in the connection piece 13a, but is provided at an intermediate position between the front support portion 11 and the rear support portion 12. In some cases, it may be provided at a position closer to the front support portion 11 than to the rear support portion 12.

  The connecting portion 14 is an elastic member including eight connecting pieces 14a provided between the connecting pieces 13a of the connecting portion 13 with a balanced interval therebetween in the circumferential direction of the front support portion 11 and the rear support portion 12. It is said. Note that a plurality of the connecting pieces 14a may be provided, and the number is not limited to eight. Further, the connecting portion 14 is formed in a curved shape so as to spread outward in the radial direction of the front support portion 11 and the rear support portion 12. Moreover, the connecting portion 14 has an urging force in a direction in which the front support portion 11 and the rear support portion 12 are separated.

  The capsular bag expansion device has a diameter of the outer peripheral edge of the front support 11 of 7.0 mm, a diameter of the opening 11a of 5.0 mm, a width of 1.2 mm, and a thickness of 0.15 to 0.4 mm. The diameter of the outer peripheral edge of the rear support portion 12 is 7.0 mm, the diameter of the opening 12 a is 4.5 mm, the width is 1.5 mm, and the thickness is 0.2 to 0.5 mm.

  The lens capsule expanding device configured as described above is manufactured through the following steps.

  First, in order to manufacture the capsular bag expansion device shown in FIGS. 10 to 12, as a first step, as shown in FIG. 13, a core C shaped like the inner shape of the capsular bag expansion device is formed by injection molding. , Formed with an alkali-soluble resin.

  As shown in FIG. 14, the core C is formed by combining molds 17a and 17b with cores 16 ... shaped like the inner shape of the capsular bag expansion device, and these molds 17a, It is formed by injecting molten alkali-soluble resin into the hollow portions Sa and Sb of 17b through a runner (not shown), and solidifying by cooling. The inner shape of each of the front support part 11, the rear support part 12 and the connection part 13 of the lens capsule expansion device is formed by the split molds 17a and 17b, and the second connection part of the lens capsule expansion device. The inner shape of 14 is formed by the core 16 that is slidably inserted into the split molds 17a and 17b.

  As the alkali-soluble resin, a polyglycolic acid resin or the like can be used, but there is no particular limitation as long as it is a resin that is soluble in alkali. Furthermore, the alkali-soluble resin is preferably a plastically deformable resin or a resin that is easily plastically deformed. The melting temperature of the alkali-soluble resin is set to a temperature higher than the melting temperature of the alkali-resistant resin that forms the lens capsule expansion device.

  As a second step, as shown in FIGS. 15 and 16 (1), the core body C is used as an inner mold 18, and the inner mold 18 and a core 19 shaped like the outer shape of the lens capsule expansion device. ... The attached split molds 20 a and 20 b are matched, and a gap space S is formed between the split molds 20 a and 20 b and the inner mold 18. The outer shapes of the front support part 11, the rear support part 12 and the connection part 13 of the lens capsule expansion device are formed by the split molds 20a and 20b, and the second connection part 14 of the lens capsule expansion device. The outer shape is formed by the core 19 which is inserted into the split molds 20a and 20b so as to be slidable.

  As a third step, as shown in FIG. 16 (2), an alkali-resistant resin melted at a temperature lower than the melting point of the alkali-soluble resin is poured into the gap space S through the runner 21.

  As a fourth step, the split molds 20a and 20b are cooled to solidify the alkali-resistant resin, thereby forming the composite 22 made of the core and the alkali-resistant resin, as shown in FIG. 16 (3), The mold is opened and the core 19 is retracted to take out the composite 22 from the split molds 20a and 20b.

  As a fifth step, a physical external force such as applying vibration, striking, or dropping is applied to the composite 21, and as shown in FIG. Deteriorate by breaking or crushing.

  As a sixth step, as shown in FIG. 18, the deteriorated composite 22 is immersed in an alkaline solution L to elute the alkali-soluble resin of the core C.

  Examples of the alkaline solution L for eluting the alkali-soluble resin of the core C include a sodium hydroxide aqueous solution and a sodium hydroxide aqueous solution.

  Thereafter, the lens capsule expanding device from which the core C has been eluted is pulled up from the alkaline solution L, washed with purified water, and then dried to obtain a finished lens capsule expanding device according to the present manufacturing method.

  Since the manufacturing method of the present invention is configured as described above, as shown in FIGS. 1 to 3 and FIGS. 10 to 12, the capsular bag expansion device has a complicated shape and is ultrafine and ultralight. Even so, it can be easily manufactured by injection molding.

  Furthermore, the manufacturing method of the present invention can be mass-produced by molding a large number of lens capsule expansion devices in the split mold.

DESCRIPTION OF SYMBOLS 1 Front support part 1a Opening part 2 Back support part 2a Opening part 3 Connection part 3a Connection piece 7a Split mold 7b Split mold 9 Composite body 11 Front support part 11a Open part 12 Back support part 12a Open part 13 Connection part 13a Connection Piece 14 Second connecting portion 19 Core 20a Splitting mold 20b Splitting mold 22 Composite C Core S S Crevice space L Alkaline solution

Claims (3)

A front support portion located on the front side in the lens capsule, a rear support portion located on the rear side in the lens capsule, and a connecting portion for connecting the front support portion and the rear support portion,
The front support portion is an elastic member formed in an annular shape having an opening at the center,
The rear support part is an elastic member formed in an annular shape having an opening in the center,
The connecting part is a method for manufacturing a capsular bag expansion device as an elastic member composed of a plurality of connecting pieces spaced from each other in the circumferential direction of the front support part and the rear support part,
(A) forming the core of the lens capsule expansion device with an alkali-soluble resin;
(B) The core body is an inner mold, the inner mold and the split mold of the lens capsule expansion device are combined, and a gap space is formed between the split mold and the inner mold,
(C) Injecting an alkali-resistant resin melted at a temperature lower than the melting point of the alkali-soluble resin into the gap space;
(D) a step of cooling the split mold to solidify the alkali-resistant resin to form a composite composed of the core and the alkali-resistant resin;
(E) applying a physical external force to the composite to degrade the core;
(F) A method for producing a lens capsule expanding device, comprising the steps of immersing the complex in an alkaline solution and eluting the core.   The lens capsule expansion device is provided with a second connecting portion that connects the front support portion and the rear support portion at a position radially outside the connecting portion, and the second connecting portion is a front support portion. 2. The capsular bag expansion device according to claim 1, wherein the elastic member is composed of a plurality of connecting pieces spaced between each other in the circumferential direction of the posterior support portion and provided between the connecting pieces of the connecting portion. Method. The outer shapes of the front support portion, the rear support portion, and the connecting portion are formed by a split mold, and the outer shape of the second connecting portion is formed by a core that is slidably inserted into the split mold. The method for manufacturing a lens capsule expanding device according to claim 2.

Images