JP2016130218A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016130218A5 JP2016130218A5 JP2015003887A JP2015003887A JP2016130218A5 JP 2016130218 A5 JP2016130218 A5 JP 2016130218A5 JP 2015003887 A JP2015003887 A JP 2015003887A JP 2015003887 A JP2015003887 A JP 2015003887A JP 2016130218 A5 JP2016130218 A5 JP 2016130218A5
- Authority
- JP
- Japan
- Prior art keywords
- gel
- composition
- dissolution test
- manufacturing
- ferric citrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 11
- 238000004519 manufacturing process Methods 0.000 claims 10
- 238000007922 dissolution test Methods 0.000 claims 9
- AJVRSHNXSHMMCH-UHFFFAOYSA-K 2-hydroxypropane-1,2,3-tricarboxylate;iron(3+);hydrate Chemical compound O.[Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O AJVRSHNXSHMMCH-UHFFFAOYSA-K 0.000 claims 6
- 229960002413 ferric citrate Drugs 0.000 claims 6
- 150000004676 glycans Polymers 0.000 claims 5
- 229920001282 polysaccharide Polymers 0.000 claims 5
- 239000005017 polysaccharide Substances 0.000 claims 5
- 150000004804 polysaccharides Polymers 0.000 claims 5
- 239000012085 test solution Substances 0.000 claims 5
- 239000007864 aqueous solution Substances 0.000 claims 4
- 238000010828 elution Methods 0.000 claims 4
- 239000000499 gel Substances 0.000 claims 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 4
- 238000010438 heat treatment Methods 0.000 claims 3
- 238000004090 dissolution Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052742 iron Inorganic materials 0.000 claims 2
- 229920001817 Agar Polymers 0.000 claims 1
- 229920001353 Dextrin Polymers 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- 229920000161 Locust bean gum Polymers 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- 235000010419 agar Nutrition 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 239000000711 locust bean gum Substances 0.000 claims 1
- 235000010420 locust bean gum Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
Claims (14)
(A)増粘多糖類の水溶液を調製する工程、及び
(B)加熱下で、該水溶液に該クエン酸第二鉄を添加・撹拌する工程、
を含む、前記製造方法。 A method for producing a gel composition containing ferric citrate,
(A) a step of preparing an aqueous solution of thickening polysaccharide , and (B) a step of adding and stirring the ferric citrate to the aqueous solution under heating,
The said manufacturing method including.
を含む、請求項1から7のいずれか一項に記載の製造方法。 Further, (C) a step of filling the obtained gel-like composition into a stick-shaped three-side seal to obtain a gel-like composition product,
The manufacturing method as described in any one of Claim 1 to 7 containing this.
(1)第16改正日本薬局方溶出試験法パドル法で第16改正日本薬局方溶出試験溶出試験液II液を試験液とし、回転数を50回/分とする溶出試験において、溶出時間が30分における鉄の溶出率が75%以上である;
(2)第16改正日本薬局方溶出試験法パドル法で第16改正日本薬局方溶出試験溶出試験液I液を試験液とし、回転数を50回/分とする溶出試験において、溶出時間が45分における鉄の溶出率が80%以上である;及び /又は
(3)第16改正日本薬局方溶出試験法パドル法で水を試験液とし、回転数を50回/分とする溶出試験において、溶出時間が45分における鉄の溶出率が80%以上である、
を有することを特徴とする、前記ゲル状組成物。 A gel-like composition comprising ferric citrate and a thickening polysaccharide, further having the following elution characteristics:
(1) 16th revised Japanese Pharmacopoeia Dissolution Test Method In the dissolution test using the 16th revised Japanese Pharmacopoeia Dissolution Test Dissolution Test Solution II as a test solution and a rotation speed of 50 times / minute, the dissolution time is 30 Iron elution rate in minutes is 75% or more;
(2) 16th revised Japanese Pharmacopoeia Dissolution Test Method According to the paddle method, the 16th revised Japanese Pharmacopoeia Dissolution Test Dissolution Test Solution I is the test solution, and the dissolution rate is 50 times / minute. And / or (3) in the dissolution test in which water is used as a test solution in the 16th revised Japanese Pharmacopoeia dissolution test paddle method and the number of revolutions is 50 times / minute. The elution rate of iron at an elution time of 45 minutes is 80% or more,
The gel-like composition characterized by having.
The gel composition according to any one of claims 10 to 13, which is used for medicine or food.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015003887A JP6206420B2 (en) | 2015-01-13 | 2015-01-13 | Method for producing gel composition containing ferric citrate at high concentration |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015003887A JP6206420B2 (en) | 2015-01-13 | 2015-01-13 | Method for producing gel composition containing ferric citrate at high concentration |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2016130218A JP2016130218A (en) | 2016-07-21 |
JP2016130218A5 true JP2016130218A5 (en) | 2017-02-09 |
JP6206420B2 JP6206420B2 (en) | 2017-10-04 |
Family
ID=56415263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015003887A Active JP6206420B2 (en) | 2015-01-13 | 2015-01-13 | Method for producing gel composition containing ferric citrate at high concentration |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP6206420B2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108371666B (en) * | 2018-02-08 | 2019-12-10 | 四川佳能达攀西药业有限公司 | application of refined Pao Tian Xiong polysaccharide in preparation of medicine for treating chronic renal failure |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0436147A (en) * | 1990-05-31 | 1992-02-06 | Lion Corp | Emulsified oil and fat food and preparation thereof |
US5753706A (en) * | 1996-12-16 | 1998-05-19 | Hsu; Chen Hsing | Methods for treating renal failure |
TWI335218B (en) * | 2003-02-19 | 2011-01-01 | Panion & Bf Biotech Inc | Ferric organic compounds, uses thereof and methods of making same |
JP3944116B2 (en) * | 2003-05-19 | 2007-07-11 | 三井農林株式会社 | Iron odor control agent |
MX2008002360A (en) * | 2005-08-18 | 2008-04-29 | Globoasia Llc | Pharmaceutical-grade ferric organic compounds, uses thereof and methods of making same. |
CN100591654C (en) * | 2005-11-30 | 2010-02-24 | 苏荣仁 | Refining method capable of increasing citric-acid solubility |
US7618485B2 (en) * | 2006-06-16 | 2009-11-17 | The Biodegradable Technologies General Partnership | Biodegradable compositions, articles prepared from biodegradable compositions and manufacturing methods |
JP5090848B2 (en) * | 2007-10-22 | 2012-12-05 | ニプロ株式会社 | Method for producing gel composition |
WO2010113325A1 (en) * | 2009-04-03 | 2010-10-07 | 日医工ファーマ株式会社 | Pectin-containing jelly preparation |
EP2868319A4 (en) * | 2012-06-29 | 2016-02-24 | Maruishi Pharma | Aripiprazole oral pharmaceutical preparation |
-
2015
- 2015-01-13 JP JP2015003887A patent/JP6206420B2/en active Active
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6013538B2 (en) | Gel sphere and method for producing the same | |
RU2012116362A (en) | ACID-RESISTANT CAPSULES | |
CN104721170B (en) | A kind of epoxy glue masticatory pattern soft capsule and preparation method thereof | |
CN103893772A (en) | Hydroxypropyl starch empty capsules and preparation process thereof | |
ATE406875T1 (en) | POLYSACCHARIDE CAPSULES AND PRODUCTION METHOD | |
CN105395513A (en) | Method for preparing hard capsule from modified starch | |
CN104798975B (en) | A kind of solution method of pulullan polysaccharide refreshing tablets production process haftplatte | |
JP2016121279A5 (en) | ||
CN104381564A (en) | Fruity jelly soft sweet and preparation method thereof | |
CN104784148B (en) | A kind of film-forming composition for preparing plant capsule and preparation method thereof | |
JP2016130218A5 (en) | ||
CN103636883B (en) | A kind of konjak soft candy and preparation method thereof | |
JPS63170310A (en) | Production of capsule | |
JP2019206599A (en) | Gelatin/pectin particles | |
CN105056245A (en) | Process for manufacturing hydroxypropyl methyl cellulose hollow capsules | |
WO2014020717A1 (en) | Spherical gel and manufacturing process therefor | |
CN103877587B (en) | Medicinal enteric hard-shell capsule of a kind of vegetable polysaccharides and preparation method thereof | |
CN101596146B (en) | Method for controlling temperature in the production process of seaweed polysaccharide plant empty capsules | |
CN105250235A (en) | Carrageenan plant soft capsule material and application thereof | |
CN105055365B (en) | A kind of manufacture craft of pulullan polysaccharide empty capsule | |
CN104000798B (en) | A kind of autonomic soft capsules | |
CN103300356A (en) | Method for preparing peach gum food | |
JP2012157278A (en) | Globular gel and method for producing the same | |
JP2014117206A5 (en) | ||
JP2016202158A (en) | Method for producing jelly-containing beverage |