JP2016087053A - Filter, manufacturing method of filter, and leak detection method of filter - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a filter for liquid filtration and the like capable of easily confirming defectiveness in deposition by a molten resin, and easily discriminating and discharging a filter with a possibility of leakage.SOLUTION: A filter comprises a filter element 2 and an inlet side container material 4 and an outlet side container material 5 disposed across the filter element 2. A joint part comprises: an inlet side joint part 4d provided in the inlet side container material 4; an outlet side joint part 5d provided in the outlet side container material 5; and a resin flow passage 8 of a molten resin 6 provided at a contact portion between the inlet side joint part 4d and the outlet side joint part 5d. A filling port 91, through which the molten resin 6 is filled, is provided on at least one of an external surface 4a of the inlet side container material 4 and an external surface 5a of the outlet side container material 5. A filling confirmation port 95 connected to the filling port 91 through the resin flow passage 8 is provided on at least one of the external surface 4a of the inlet side container material 4 and the external surface 5a of the outlet side container material 5.SELECTED DRAWING: Figure 5

Description

  The present invention relates to a filter for filtering a liquid, a method for manufacturing the filter, and a leak inspection method for the filter. In particular, it relates to a liquid containing blood components and a blood treatment filter for removing undesired components such as aggregates and leukocytes from blood, a method for producing the filter, and a leak inspection method for the filter. Disposable blood treatment filter used for the purpose of removing microaggregates and leukocytes that cause side effects from blood products, erythrocyte products, platelet products, plasma products, etc., a method for producing the filter, and a leak inspection method for the filter It is about.

  It is becoming common for whole blood collected from a donor to be separated into blood component preparations such as erythrocyte preparations, platelet preparations, plasma preparations, etc., stored, and then transfused. Since microaggregates and white blood cells contained in these blood products cause various side effects of blood transfusion, these undesired components are removed before blood transfusion, or these are undesirable after blood collection. Many methods are used to transfuse blood that has been stored after removing the components.

  The most common method for removing these undesirable components from the blood product is to treat the blood product with a blood processing filter. There are two types of blood treatment filters: filter elements made of non-woven fabric or porous material, for example, a flexible container as disclosed in Patent Documents 1 to 5, and a rigid element such as polycarbonate. Is used.

  Normally, when processing blood products with a blood processing filter, a blood product bag containing the blood product to be processed is connected to the inlet of the blood processing filter, and the blood product bag is positioned 20 cm to 100 cm higher than the blood processing filter. The blood product is introduced into the blood processing filter from the blood product bag by the action of gravity. On the other hand, a recovery bag containing the filtered blood product is connected to the outlet of the blood treatment filter, and the collection bag is placed at a position lower by about 50 to 100 cm than the blood treatment filter. The blood product is stored in a collection bag. At this time, in the space on the inlet side of the filter element in the blood processing filter container, a pressure loss occurs due to the resistance of the filter element, and the pressure becomes positive. On the other hand, in the space on the outlet side from the filter element, the blood product flows out from the outlet, so that the negative pressure is reversed.

  In the blood treatment filter of a flexible container as shown in Patent Documents 1 to 5, since the container is flexible, the container is inflated by a positive pressure in the space on the inlet side, and the filter element is the container of the container. Pressed against the exit side. On the other hand, in the space on the outlet side, the container is brought into close contact with the filter element by the negative pressure, and the outlet opening is blocked. That is, blood tries to flow out of the filter, but it is difficult for blood to flow out because the opening is closed.

  In contrast, a blood treatment filter using a rigid container does not undergo major deformation even during filtration, and the filter element is pressed to the outlet side, and the outlet opening is blocked. There is no. Such a hard container is formed by fitting an inlet side container material and an outlet side container material, and presses rib-shaped convex portions provided respectively on the inlet side container material and the outlet side container material. The outer edge of the filter element is sandwiched. By compressing the convex portions with high density, it is possible to prevent the occurrence of a side leak in which blood passes over the outer edge of the filter element and passes without being filtered.

JP-A-11-216179 JP-A-7-267871 International Publication No. 2004/050147 International Publication No. 95/17236 European Patent Application No. 0526678

  In the manufacture of a filter for filtering a liquid having an inlet side container material and an outlet side container material, a molten resin is used to make the inlet side space and the outlet side space in the container hermetically sealed. The container material and the outlet side container material are often welded. When welding the inlet-side container material and the outlet-side container material with molten resin, if there is a deficiency in the welding due to insufficient molten resin for welding, leakage of liquid will occur from inside the container. To do. When liquid leakage (leakage) occurs, liquid that has not been filtered leaks out of the container by the filter element, and there is a problem that the filtration performance and the recovery rate are lowered. Therefore, in the past, it was necessary to select a leaking filter. However, for this purpose, an inspection process for a leak test is required, which complicates the manufacturing process, and the leak test. Special equipment was also required, which was a problem in that the manufacturing cost increased.

  The present invention aims to solve the above-mentioned problems, and a filter for liquid filtration that can easily check for defects in welding due to a molten resin and easily select and eliminate a filter that may leak. An object of the present invention is to provide a method for manufacturing the filter and a method for inspecting the leak of the filter.

  As a result of diligent research to solve the above-mentioned problems, the inventors have provided an inlet for filling the molten resin on the outer surface of the inlet side container material or the outer surface of the outlet side container material and filled the molten material. It is found that by providing an outlet for confirming that the resin has reached a predetermined place, it is possible to visually check the filling state of the molten resin, and it is possible to easily select whether or not it is a leakage filter. I came up with the invention.

  That is, the present invention is a filter for filtering a liquid, comprising a filter element, and an inlet side container material and an outlet side container material arranged with the filter element interposed therebetween, and the inlet side container material and the outlet side The internal space formed by the container material is partitioned into an inlet space and an outlet space by a filter element, and the filter element is provided at the periphery of the filtration surface on the inlet space side and the filtration surface on the outlet space side and the pair of filtration surfaces. And the inlet side container material and the outlet side container material have a joint part that surrounds and joins the end face of the filter element, and the joint part is provided on the inlet side provided in the inlet side container material. A joint portion, an outlet side joint portion provided in the outlet side container material, and a resin flow path of a molten resin provided in a contact portion between the inlet side joint portion and the outlet side joint portion, and the inlet side Container material and outlet side container material are resin At least one of the outer surface of the inlet-side container material and the outer surface of the outlet-side container material is provided with a filling port filled with the molten resin, and is attached to the outside of the inlet-side container material. At least one of the surface and the outer surface of the outlet side container material is provided with a filling confirmation port connected to the filling port via a resin flow path.

  In addition, the method for manufacturing the filter includes a container material molding step in which the above-described inlet-side container material is injected with one mold, and the above-mentioned outlet-side container material is injection-molded with the other mold, and the inlet-side container material or the outlet A loading step of loading the filter element into the side container material, a joining step of abutting the inlet side container material and the outlet side container material with the filter element loaded, and the inlet side container material and the outlet side container material. A fixing step of filling the resin flow path provided in the joint portion with the molten resin and bonding the inlet side container material and the outlet side container material, and in the fixing step, the molten resin is filled from the filling port.

  Further, in the leak inspection method for the filter described above, it is confirmed that the liquid tightness of the joint portion between the inlet side container material and the outlet side container material is high by checking the molten resin from the filling confirmation port. The confirmation of the molten resin from the filling confirmation port includes not only the case of confirming the molten resin in a molten state, but also the case of confirming the molten resin after being cured.

  In the above-described filter, the molten resin is filled into the resin flow path from the filling port, and the joint portion between the inlet side container material and the outlet side container material is bonded. Here, when the molten resin filled from the filling port reaches the filling confirmation port, the filling state of the molten resin can be visually confirmed from the filling confirmation port, and as a result, the resin flow between the filling port and the filling confirmation port can be confirmed. It can be confirmed that the molten resin is filled in the passage. On the contrary, if the molten resin cannot be confirmed from the filling confirmation port, it can be determined that the leakage filter has a possibility of leakage, and the leakage filter can be easily selected and eliminated.

  Moreover, in said filter, it can also be set as the aspect which the entrance side junction part and the exit side junction part fitted each other. In order to realize this aspect, in the above-described filter manufacturing method, in the joining step, the pair of molds are matched and the filter element is sandwiched between the inlet-side container material and the outlet-side container material. In the state, it is also possible to fit the inlet side joint and the outlet side joint. By fitting the inlet-side joint portion and the outlet-side joint portion with each other, it is preferable that a stronger and stable joining between the inlet-side container material and the outlet-side container material is possible.

  In the above filter, the resin flow path is provided over the entire circumference along the end face of the filter element, and the inlet side joint and the outlet side joint are bonded by the molten resin filled in the resin flow path. It is preferable that If the resin flow path is not provided over the entire circumference along the end face of the filter element, there will be a place where at least a part is not filled with the molten resin, and there is a high risk that the airtightness and liquid tightness will be reduced. According to this, this risk can be reduced.

  In the above filter, the inlet side container material has an inlet port into which liquid is introduced, the outlet side container material has an outlet port through which liquid is discharged, and at least one of the filling port and the filling confirmation port is It is possible to avoid the inlet port and the outlet port, and it is also possible to provide both the filling port and the filling confirmation port away from the inlet port and the outlet port. By providing the filling port and the filling confirmation port while avoiding the inlet port and the outlet port, the structure is prevented from becoming complicated and the manufacturing becomes easy.

  Further, a plurality of filling ports or a plurality of filling confirmation ports may be provided for one resin flow path. By providing a plurality of filling ports, it is possible to improve the filling efficiency of the molten resin, and by providing a plurality of filling confirmation ports, it becomes easy to check the filling state in the resin flow path.

  In addition, a plurality of filling confirmation ports can be formed in both the inlet side container material and the outlet side container material, and in this case, when it is necessary to provide while avoiding the inlet port and the outlet port, The number of candidates as places where the filling confirmation opening can be formed increases, and it becomes easier to form the filling confirmation opening at the optimum place.

  In addition, a plurality of filling ports can be provided together in the inlet side container material or the outlet side container material. In this case, when filling the molten resin, the filling port is melted only from one side surface where the filling port is provided. Since the resin is filled, the structure and control of the apparatus for filling the molten resin can be simplified, which is preferable.

  The filling port and the filling confirmation port are alternately arranged along the resin flow path, and the volume of the plurality of divided flow paths divided by the filling port and the filling confirmation port is the same in the resin flow path. It may be a filter. In this case, complicated control for aligning the timing at which the molten resin filled from each filling port reaches each filling confirmation port becomes unnecessary, which is preferable.

  Further, at least one of the filling confirmation port and the filling port may be provided in plural, and the filter may be arranged at equal intervals along the resin flow path provided over the entire circumference along the end face of the filter element. In this case, there is no bias in the arrangement of the filling confirmation port and the filling port, which is preferable because appropriate filling of the molten resin and visual confirmation are possible.

  According to the present invention, it is possible to easily confirm a defect in welding due to the molten resin, and it is possible to easily select and eliminate a filter that may leak.

FIG. 3 is a plan view of the blood processing filter according to the first embodiment of the present invention, partially broken and viewed from the inlet side container material side. It is the top view which looked at the blood processing filter which concerns on this embodiment partially, and was seen from the outlet side container material side. It is a side view which shows the blood processing filter which concerns on this embodiment partially broken. It is sectional drawing along the IV-IV line of FIG. It is a figure explaining filling of the molten resin in the blood processing filter which concerns on this embodiment, (a) is a perspective view, (b) is a top view. It is a figure explaining the relationship between a filling confirmation port and molten resin, (a) shows the state which cannot confirm molten resin visually from a filling confirmation port, (b) shows molten resin visually from a filling confirmation port. The state which can be confirmed is shown, (c) is a figure which can confirm a molten resin visually from a filling confirmation port, and is a figure which shows the state which the molten resin closed the filling confirmation port completely. It is a figure which shows the relationship between arrangement | positioning of a filling port and a filling confirmation port, and the flow at the time of filling with molten resin, (a) is the filling port which concerns on this embodiment, arrangement | positioning of a filling confirmation port, and a division | segmentation flow path, FIG. 5B is a cross-sectional view taken along lines b1-b1, b2-b2, b3-b3, and b4-b4 in FIG. In the sectional view of (b), for convenience, the filling port is shown on the outlet container material side (lower side), and the filling confirmation port is shown on the inlet container material side (upper side). It is a figure which shows the relationship between the arrangement | positioning of the filling port of the blood processing filter which concerns on other embodiment, and a filling confirmation port, and the flow at the time of filling with molten resin, (a) is a top view which shows 2nd Embodiment. (B) is a plan view showing the third embodiment. It is a figure which shows the blood processing filter which concerns on 4th Embodiment, (a) is a top view which shows the relationship between arrangement | positioning of a filling port which concerns on 4th Embodiment, and a filling confirmation port, and a division | segmentation flow path, (B) is sectional drawing along each line of b1-b1, b2-b2, b3-b3, and b4-b4 of (a). It is a figure which shows the blood processing filter which concerns on 5th Embodiment, (a) is a top view which shows the relationship between the arrangement | positioning of a filling port which concerns on 5th Embodiment, and a filling confirmation port, and a division | segmentation flow path, (B) is sectional drawing along each line of b1-b1 and b2-b2 of (a). It is a figure shown comparing with the blood processing filter concerning a 1st embodiment about the blood processing filter concerning a 6th embodiment, and (a) is a filling mouth concerning a 1st embodiment, and a filling confirmation mouth. It is a top view which shows the relationship between arrangement | positioning and a divided flow path, (b) is a top view which shows the relationship between arrangement | positioning of a filling port which concerns on 6th Embodiment, and a filling confirmation port, and a divided flow path. The modification of the blood processing filter which concerns on this embodiment is shown, (a)-(f) is a top view of each aspect from which an external shape differs. It is a graph which shows the measurement result which measured the thickness of the filter element before and behind shaping | molding. It is explanatory drawing for demonstrating the container material shaping | molding process in manufacture of the blood processing filter which concerns on embodiment. It is explanatory drawing for demonstrating the loading process in manufacture of the blood processing filter which concerns on embodiment. It is explanatory drawing for demonstrating the joining process and the adhering process in manufacture of the blood processing filter which concerns on embodiment of this invention.

  Hereinafter, embodiments of the filter according to the present invention will be described with reference to the drawings, taking a blood processing filter as an example. However, the filter according to the present invention is not limited to a blood processing filter, and a wide range of filters for filtering liquids. included.

  The blood processing filter according to the first embodiment is for removing undesirable components from a liquid or blood containing blood components (hereinafter referred to as a liquid to be processed). The liquid containing blood components also includes liquids containing blood products such as whole blood preparations for blood transfusion, erythrocyte preparations, platelet preparations and plasma preparations.

  As shown in FIGS. 1 to 4, the blood processing filter 1 according to the present embodiment has a rectangular shape as a whole, and includes a sheet-like filter element 2 and a hard container 3. The rigid container 3 has an inlet side container material 4 and an outlet side container material 5 which are arranged with the filter element 2 sandwiched therebetween and are fixed to each other, and the filter element 2 causes the internal space 3s to become an inlet space 4s and an outlet space 5s. It is partitioned. The inlet side container material 4 is provided with an inlet port 4c for introducing the liquid to be treated therein, and the outlet side container material 5 is provided with an outlet port 5c for discharging the processing liquid processed by the filter element 2. In addition, fixation means that it is a concept including welding and adhesion. In addition, the blood processing filter 1 may be any of a rectangular shape, a disk shape, an oblong disk shape, and the like, but a rectangular shape is preferable in order to reduce material loss during manufacturing. Squares and rhombuses are also considered as a kind of rectangular shape.

  As materials of the inlet side container material 4 and the outlet side container material 5 which are the main parts of the hard container 3, a resin having a Young's modulus of 1 MPa or more at room temperature is preferable in order to suppress deformation during filtration, and further, a Young's modulus of 2 MPa or more is preferable. Resins are preferred. For example, polycarbonate, polyester, polyamide, polystyrene, HIPS, ABS, polyethylene, polypropylene, polyvinyl chloride and the like can be used. More preferred is a polycarbonate having high heat resistance. In addition, the measurement of Young's modulus can use the result measured according to ISO527-1.

  In the present embodiment, ribs 4 h and 5 h are provided between the hard container 3 and the filter element 2. As a result, even if the internal pressure of the blood treatment filter 1 becomes a negative pressure during the filtration, the filter element 2 does not stick to the hard container 3, so that the occurrence of an extension of the filtration time is less likely to occur.

(About filter elements)

  The filter element 2 is a rectangular filter medium having a filtration surface 2a on the inlet space 4s side, a filtration surface 2b on the outlet space 5s side, and an end surface 2c along the periphery of the pair of filtration surfaces 2a and 2b. For the filter element 2, a known porous medium such as a fibrous porous medium such as a nonwoven fabric or a woven fabric, or a porous body having three-dimensional network continuous pores such as a sponge-like structure can be used. Examples of these materials include polypropylene, polyethylene, styrene-isobutylene-styrene copolymer, polyurethane, and polyester. When the filter element 2 is a nonwoven fabric, it is particularly preferable from the viewpoint of productivity.

  The filter element 2 may be a single filter element or may be composed of a plurality of filter elements made of a plurality of laminated sheet-like filter materials. In the case of a plurality of filter elements, a first filter element disposed mainly upstream to remove mainly microaggregates and a downstream of the first filter element to remove undesirable components other than microaggregates. It preferably consists of a second filter element arranged.

  For example, a filter material made of a non-woven fabric having a fiber diameter of several to several tens of μm is arranged on the inlet side as a first filter element mainly for removing aggregates, and then the fiber diameter is 0.3 to 3.0 μm. A filter material made of a nonwoven fabric can be used as a second filter element for removing undesirable components other than aggregates. The first and second filter elements may each be composed of a plurality of types of filter materials having different fiber diameters, or only one of the first and second filter elements may be composed of a plurality of types of filter materials.

  For example, a first filter element made of a nonwoven fabric having a fiber diameter of 30 to 40 μm and / or a nonwoven fabric having a fiber diameter of 10 to 20 μm is arranged on the upstream side, and the fiber diameter is 1.5 to downstream of the first filter element. The filter element 2 may be formed by arranging a second filter element made of a non-woven fabric having a diameter of 2.5 μm and / or a non-woven fabric having a fiber diameter of 0.5 to 1.8 μm. In addition, although the nonwoven fabric of a thick fiber diameter and the nonwoven fabric of a thin fiber diameter may be arrange | positioned alternately, it is preferable that the nonwoven fabric of a thick fiber diameter is arrange | positioned upstream.

  As described above, the rigid container 3 is a rectangular container having a predetermined thickness, and includes the inlet-side container material 4 and the outlet-side container material 5 arranged with the filter element 2 interposed therebetween. The internal space 3s of the rigid container 3 is partitioned by the filter element 2 into the inlet space 4s side and the outlet space 5s side.

  The inlet-side container material 4 is a rectangular member (see FIG. 2) obtained by cutting the rigid container 3 in half in the thickness direction, and has an outer surface 4a and an inner surface 4b. On the other hand, the outlet side container material 5 is a rectangular member which is the remaining part of the hard container 3, and has an outer surface 5a and an inner surface 5b. The inner surface 4b of the inlet side container material 4 and the inner surface 5b of the outlet side container material 5 are surfaces facing each other. Moreover, the outer surface 4a of the inlet side container material 4 is a surface opposite to the inner surface 4b, and the outer surface 5a of the outlet side container material 5 is a surface opposite to the inner surface 5b. In the following description, the outer surface 4a of the inlet side container material 4 and the outer surface 5a of the outlet side container material 5 are referred to as outer surfaces 4a and 5a, respectively.

  Of the four corners of the outer surface 4a of the inlet side container material 4, an inlet port 4c is provided at one corner. Out of the four corners of the outer surface 5a of the outlet side container material 5, the outlet port 5c is provided at the corner opposite to the corner provided with the inlet port 4c. The inlet port 4c is formed with a flow path that communicates with the inlet space 4s in the rigid container 3, and the tip is open. The outlet port 5c is formed with a flow path that communicates with the outlet space 5s in the rigid container 3, and the tip is open. When the blood processing filter 1 is used, the inlet port 4c and the outlet port 5c are provided such that the inlet port 4c projects upward and the outlet port 5c projects downward and opens.

  On the inner surface 4b side of the inlet side container material 4 and the inner surface 5b side of the outlet side container material 5, there are respectively provided an inlet side joint portion 4d and an outlet side joint portion 5d that extend along a rectangular outer edge and fit to each other. (See FIG. 4). The inlet side joint portion 4d and the outlet side joint portion 5d are in a male-female relationship and surround the end surface 2c of the filter element 2 to form a joint portion 7. In the following description, the joint portion 7 will be described in more detail by taking as an example a structure in which the inlet side joint portion 4d is the male side and the outlet side joint portion 5d is the female side. However, even if the relationship between the male and female is reversed. good.

  4 d of entrance side junction parts are the convex-shaped parts provided along the periphery of the inlet side container material 4, and have the front end surface 41 and the internal peripheral surface 42. As shown in FIG. On the other hand, the outlet side joint portion 5d is provided along the periphery of the outlet side container member 5, and a wall portion 52 that contacts and engages with the inner peripheral surface 42 of the inlet side joint portion 4d, and the inlet side joint. And a seat portion 51 that comes into contact with the distal end surface 41 of the portion 4d. A resin flow path 8 is provided at a contact portion between the seat portion 51 and the front end surface 41 of the inlet side joint portion 4d, and the molten resin 6 filled in the resin flow path 8 is cured to cure the inlet side. The container material 4 and the outlet side container material 5 are bonded together.

  The resin flow path 8 is a cavity constituted by a groove 4x and a groove 5x each having a U-shaped cross section provided in the inlet side joint portion 4d and the outlet side joint portion 5d, respectively. The inlet side joint portion 4d and the outlet side joint portion 5d are joined by being fitted to each other, and further, the molten resin 6 is filled in the resin flow path 8, so that the entire circumference of the joint portion 7 is covered. It is welded in a band shape. In this way, the joining portion 7 is joined not only by fitting but also through the molten resin 6, so that the joining portion 7 is joined more firmly, and further, welded in a band shape over the entire circumference of the joining portion 7, so that the rigid container 3 is sealed, and airtightness and liquid tightness are enhanced.

  As shown in FIG. 4, on the inner side of the joint portion 7, there is provided a grip portion 9 that sandwiches and compresses the outer edge portions 2 d and 2 e of the pair of filtration surfaces 2 a and 2 b that are the front and back of the filter element 2. Yes. The grip portion 9 is formed by an inlet side compression portion 4 f formed on the inlet side container material 4 and an outlet side compression portion 5 f formed on the outlet side container material 5.

  The inlet side compression portion 4f is formed by a step in which the peripheral edge of the inlet side container material 4 is curved toward the inner surface side (outlet side container material 5 side) and bent outward. Similarly, the outlet-side compression portion 5f is formed by a step whose peripheral edge of the outlet-side container material 5 is curved toward the inner surface side (inlet-side container material 4 side) and bent outward. The inlet side compression part 4f and the outlet side compression part 5f are compressed by sandwiching the outer edge parts 2d, 2e of the pair of filtration surfaces 2a, 2b on the front and back of the filter element 2.

  The grip portion 9 compresses a range of a width L of 1 to 5 mm from the outermost edge of the filter element 2 by the inlet side compression portion 4f and the outlet side compression portion 5f. Thus, by making the width L of the gripping part 9 larger than 1 mm, it is possible to prevent the filter element 2 from being detached from the gripping part 9 when the filter element 2 is crushed, and the occurrence of defective removal can be suppressed. In addition, by making the width L of the gripping part 9 that actually creates an area that cannot be used for filtration smaller than 5 mm, it is easy to design the blood treatment efficiently or economically.

  On the inner surface side of the inlet side container member 4, a plurality of convex ribs 4h are provided in an inner region surrounded by the inlet side compression portion 4f. Further, on the inner surface side of the outlet side container material 5, a plurality of convex 5h are provided in an inner region surrounded by the outlet side compression portion 5f. The rib 4h of the inlet side container material 4 presses the filtration surface 2a of the filter element 2, and secures an inlet space 4s between the inner surface of the inlet side container material 4 and the filtration surface 2a. Similarly, the rib 5h of the outlet side container material 5 presses the filtration surface 2b of the filter element 2, and secures an outlet space 5s between the inner surface of the outlet side container material 5 and the filtration surface 2b.

  As described above, in the blood treatment filter 1 according to the present embodiment, the pair of filtration surfaces 2a and 2b of the filter element 2 are sandwiched between the ribs 4h and 5h, and are partially compressed, whereby the inlet space 4s and The exit space 5s is secured in an effective and stable state. In the present embodiment, the rib 4h of the inlet side container material 4 is taller than the rib 5h, and as a result, the inlet space 4s is secured wider than the outlet space 5s. The height of the rib 4h and the rib 5h may be the same, or conversely, the rib 5h may be higher.

  The thickness D of the filter element 2 in the grip 9 needs to be compressed to 0.05 to 0.5 times the original thickness D0, and D / D0 = 0.05 to 0.5. . Here, since the filter element 2 cannot be compressed below the density of the original resin, it is practically difficult to make D / D0 = less than 0.05. On the other hand, when D / D0 is larger than 0.5, it cannot be said that the filter element 2 is in a high-density compressed state, and undesirable components get over the outer edge portions 2d and 2e of the filter element 2 to cause side leakage (side flow). ) Occurs, the performance of removing undesirable components such as leukocytes is reduced. This becomes prominent due to the shrinkage of the container due to the high temperature during steam sterilization at high temperature and pressure. That is, it is important for the filter element 2 to have a thickness D that is compressed to a level close to the density of the original resin, and as a result, it is possible to improve the removal performance of undesirable components such as leukocytes. Therefore, for example, when the original thickness D0 of the filter element 2 is 10 mm, it is necessary to compress the thickness D in the grip portion 9 to about 0.5 mm to 5 mm. Further, in order to compress the thickness D in the grip portion 9 to 0.05 to 0.5 times the original thickness D0, the distance of the grip portion 9, that is, the inlet side compression portion 4f and the outlet side compression portion 5f face each other. The molding die is adjusted so that the surface distance is 0.05 to 0.5 times the original thickness D0. In addition, D / D0 = 0.07 to 0.45 is preferable, and D / D0 = 0.1 to 0.15 from the viewpoint of achieving both ease of production and improvement in removal performance of undesirable components such as leukocytes. 0.4 is more preferable.

  Next, the case where the original thickness D0 of the filter element 2 is verified from the molded blood treatment filter 1 will be described. When the molded blood treatment filter 1 is disassembled and the thickness of the portion not gripped is measured, the maximum value D1 of the thickness is an error of several percent with respect to the original thickness D0 before being sandwiched by the gripping portion 9. It is the range, and the maximum value D1 can be regarded as the original thickness D0. More specifically, the maximum value D1 is a dent in the vicinity of the center of the filter element 2 other than the portion where the filter element 2 is deformed by the convex portion in the hard container 3 such as the grip portion 9 and the ribs 4h and 5h. It is the maximum value of the thickness of five places selected from the part where the shape is not changed, and the maximum value D1 can be regarded as the original thickness D0 before being sandwiched by the grip portion 9.

  The experimental results supporting this verification will be described with reference to FIG. FIG. 13 is a graph comparing the thickness of the cross section of the filter element 2 (polyester nonwoven fabric) before and after molding the blood treatment filter 1 (after disassembling the blood treatment filter 1 after molding). As shown in FIG. 13, in the case of this blood processing filter 1, the difference between the original thickness D0 and the maximum value D1 was about 3% of the original thickness D0. That is, it can be confirmed that the difference between the original thickness D0 of the filter element 2 and the maximum value D1 of the filter element 2 obtained by disassembling the molded blood treatment filter 1 is about several percent of the original thickness D0. It was. In addition, about the measurement time of the thickness after dismantling, even if it compared the measurement result of thickness with the thing immediately after dismantling and the thing left for one week after dismantling, there was almost no change. Therefore, it was confirmed that the time elapsed until the measurement after dismantling has little influence on the thickness measurement result.

  From the above results, when it is easier to detect the maximum value D1 of the filter element 2 obtained by disassembling the blood treatment filter 1 after molding than grasping the original thickness D0 before molding, The maximum value D1 can be detected instead of the thickness D0, and the value D / D0 can be grasped by regarding the maximum value D1 as the original thickness D0. Specifically, since D1 should be the same as D0 or several percent smaller (ie, D0 ≧ D1), if thickness D is 0.5 times or less of maximum value D1 (ie, D / D1) ≦ 0.5) and the thickness D is 0.5 times or less of the original thickness D0 (that is, D / D0 ≦ 0.5). On the other hand, since the filter element 2 cannot be compressed below the density of the original resin, it is difficult to think that the lower limit value is less than 0.05. Therefore, while the thickness D is 0.05 or more of the maximum value D1, It is unlikely that the thickness D is less than 0.05 of the original thickness D0. That is, if D / D1 = 0.05 to 0.5, it can be regarded as D / D0 = 0.05 to 0.5.

  Further, the difference between the maximum value D1 and the original thickness D0 is about a few percent of the original thickness D0 and is considered to be almost negligible. However, the error of this few percent is assumed to be D / D1> 0.5. Even in this case, if D0 is actually detected, it is not denied that D / D0 ≦ 0.5 may be satisfied.

  Next, the case where D / D0 = 0.07 to 0.45 and the case where D / D0 = 0.1 to 0.4 will be described. The value of D / D0 can be physically below these lower limits 0.07 and 0.1. For this reason, the lower limit value of D / D1 in which the lower limit value of D / D0 can surely be 0.07 and 0.1 or more is examined. Here, assuming that the difference between the maximum value D1 and the original thickness D0 is a very large value compared to the above experiment (see FIG. 13), for example, 10%, when D / D0 = 0.07. Is D / D1 = 0.078 (= 0.07 / 0.9), and when D / D0 = 0.1, D / D1 = 0.11 (= 0.1 / 0.9) ). That is, at least when D / D1 = 0.078 to 0.45, there is no reason to consider D / D0 = 0.07 to 0.45, and D / D1 = 0.11 to 0. In the case of 4, it is reasonable to consider D / D0 = 0.1 to 0.4.

(About resin flow path, molten resin filling port, and filling confirmation port)

  As shown in FIG. 5, the resin flow path 8 includes a molten resin 6 filling inlet (hereinafter referred to as “filling port”) 91, a molten resin 6 filling outlet (hereinafter referred to as “filling confirmation port”) 95, Is provided. The filling port 91 and the filling confirmation port 95 are provided on the outer surface 4a of the inlet side container material 4 or the outer surface 5a of the outlet side container material 5 in order to function as an opening through which the resin flow path 8 communicates with the outside. The filling port 91 and the filling confirmation port 95 are connected to each other through the resin flow path 8.

  In particular, the filling confirmation port 95 is disposed at the flow end (final filling portion) of the molten resin 6 filled from the filling port 91. As a result, the moldability is improved due to the outgassing effect, and the airtightness and liquid tightness are improved. The stability of sex is also improved. In addition, the resin flow path 8 according to the present embodiment is continuously provided over the entire circumference along the end surface 2 c of the filter element 2, that is, over the entire circumference of the joint portion 7. As a result, the hard container 3 is reliably sealed, and the air tightness and liquid tightness are enhanced. In this embodiment, as is clear from the fact that the resin flow path 8 is provided over the entire circumference of the joint portion 7, the resin flow path 8 is rectangular and has no end portion of the flow path. Therefore, the above-mentioned flow end means a position farthest from one or a plurality of filling ports 91.

  In the present embodiment, out of the four corners of the rectangular outlet-side container material 5, the corners provided with the outlet ports 5 c are avoided, and the two corners that are opposite to each other are filled with the filling ports 91. Is provided. On the other hand, two filling confirmation ports 95 are provided so as to be paired, and one filling confirmation port 95 is formed at the inlet port 4c among the four corners of the rectangular inlet side container material 4. And two corners overlapping the filling port 91 are provided. The other filling confirmation port 95 is not the inlet side container material 4 but the outer surface 5a of the outlet side container material 5 and is provided at a corner portion on the back side of the inlet port 4c of the inlet side container material 4. .

  In the present embodiment, the resin flow path 8 is continuously provided over the entire circumference of the joint 7, but instead of being continuously provided, a part of the resin flow path 8 is blocked (closed). It is also possible to adopt an aspect. However, when a portion where the molten resin 6 does not flow by blocking at least a part of the resin flow path 8 is provided, the molten resin 6 is not filled in that portion. Increased risk of loss of density.

  Therefore, it is preferable that at least 90% or more of the entire circumference surrounding the end surface 2 c of the filter element 2 is bonded by the molten resin 6. For example, when the area bonded by the molten resin 6 is less than 90%, a separate leakage test inspection process may be required to ensure high quality. Further, if this region is less than 90%, for example, in order to ensure the airtightness of the part that is not bonded, it is necessary to firmly fit and contact the inlet side container material 4 and the outlet side container material 5, Cracks are likely to occur due to the overload.

  The blood processing filter 1 according to the present embodiment has been described above. For example, the filling port 91 and the filling confirmation port 95 are not limited to two or more, and may be a single number. The number with the filling confirmation port 95 does not need to be paired, and therefore may not be the same. However, in consideration of productivity, the number of filling ports 91 and the number of filling confirmation ports 95 are preferably paired (same number).

  Next, the action of the blood processing filter 1 according to the present embodiment, the principle for achieving this action, and other embodiments will be described.

  The blood processing filter 1 (see FIG. 5) includes an inlet-side container material 4 and an outlet-side container material 5, and the inlet-side container material 4 and the outlet-side container material 5 are a molten resin filled in a resin flow path 8. 6 is bonded. At least one of the outer surface 4a of the inlet side container material 4 and the outer surface 5a of the outlet side container material 5 is provided with a filling port 91 filled with the molten resin 6, and the outer surface 4a and outlet of the inlet side container material 4 are provided. At least one of the outer surfaces 5 a of the side container material 5 is provided with a filling confirmation port 95 connected to the filling port 91 through the resin flow path 8.

  The amount of the molten resin 6 necessary for spreading into the resin flow path 8 can be determined in advance based on the volume of the resin flow path 8 (hereinafter referred to as “necessary amount”). Therefore, normally, the filling of the molten resin 6 is started and the filling is finished at a timing when the filling of a necessary amount is completed, and then a leak inspection is performed.

  In the case of the blood processing filter 1, if the molten resin 6 can be visually confirmed from the filling confirmation port 95, it can be estimated that the molten resin 6 filled from the filling port 91 has reached at least the filling confirmation port 95. That is, it is visually confirmed that the molten resin 6 is spread in the resin flow path 8 between the filling port 91 and the filling confirmation port 95 and the molten resin 6 is sufficiently filled in the resin flow path 8. (See FIGS. 6B and 6C). That is, if the molten resin 6 can be confirmed from the filling confirmation port 95, it is estimated that at least the inside of the resin flow path 8 is filled with the molten resin 6, and therefore, it can be determined that the blood treatment filter 1 is a non-defective product that has no possibility of leakage.

  On the other hand, there are individual differences in the manufactured blood treatment filter 1, and if the inner diameter of the resin flow path 8 is not uniform or if there is a defect in the viscosity of the molten resin 6, the molten resin 6 is filled with a confirmation port 95. May not reach (see FIG. 6A). In such a case, the molten resin 6 cannot be visually confirmed from the filling confirmation port 95. As a result, it cannot be confirmed whether or not the resin flow path 8 is completely filled with the molten resin 6, and conversely, it can be determined that this is a defective leakage filter that cannot completely eliminate the possibility of leakage. . As a result, the leak filter can be easily selected and eliminated by simple visual leak inspection. Note that the visual confirmation of the molten resin 6 from the filling confirmation port 95 is not limited to the case of confirming the molten resin 6 in a molten state, but includes the case of confirming the molten resin 6 after being cured.

  The above is the basic principle, but in the blood treatment filter 1 according to the present embodiment, two (plural) filling ports 91 and two (plural) filling ports are disposed on the endless rectangular annular resin flow path 8. A filling confirmation port 95 is provided. Hereinafter, with reference to FIG. 7, confirmation of the filling state of the molten resin 6 when a plurality of filling ports 91 and a plurality of filling confirmation ports 95 are provided on one resin flow path 8 will be described.

As shown in FIG. 7, the resin flow path 8 can be divided into a plurality of divided flow paths 8a, 8b, 8c, 8d divided by a plurality of filling ports 91 and a plurality of filling confirmation ports 95. . 7A and 7B are explanatory views showing the blood treatment filter 1 in a simplified manner, where FIG. 7A is a plan view seen from one outer surface 4a side, and FIG. 7B is b ₁ -b _{1 in} FIG. _line, b 2 -b _2-wire, b 3 -b _3-wire, a cross-sectional view taken along each line b 4 -b _4-wire. The lengths of the divided flow paths 8a, 8b, 8c, 8d of the blood treatment filter 1 are the same, and the divided flow paths 8a, 8b, 8c, 8d are cross sections orthogonal to the direction in which the molten resin 6 flows. The area is the same. That is, the volume of each divided flow path 8a, 8b, 8c, 8d is the same.

  As a result, when the molten resin 6 is filled from the two filling ports 91 at the same timing and the same flow rate, the two filling confirmation ports 95 should be reached at the same elapsed time (timing). Thus, the filling of the molten resin 6 is completed. Thereafter, if the molten resin 6 can be visually confirmed from both of the two filling confirmation ports 95, it can be determined that the blood treatment filter 1 is a good product, and conversely, at least one of the filling confirmation ports 95 must be able to confirm the molten resin 6. Therefore, it can be determined that there is a possibility of leakage, and it is eliminated as a leakage filter that may be defective.

  The above operation is not limited to the blood processing filter 1 according to the present embodiment. For example, the blood processing filters 1A, 1B, 1C, 1D, and 1E according to the respective embodiments as shown in FIGS. Even play.

  First, FIG. 8A is a plan view showing an outline of a blood processing filter 1A according to the second embodiment in which the blood processing filter 1 is simplified, and FIG. 8B is a plan view according to the third embodiment. It is a top view which shows the outline of the blood processing filter 1B which concerns.

  For example, as in the blood processing filter 1A according to the second embodiment (see FIG. 8A), it is possible to provide only one pair of the filling port 91 and the filling confirmation port 95 on the rectangular annular resin flow path 8. It is. In this case, the number of the divided flow paths 81a and 81b divided by the filling port 91 and the filling confirmation port 95 is two, and the two divided flow paths 81a and 81b are designed to have the same volume. Can be expected. Further, as in the blood processing filter 1B according to the third embodiment (see FIG. 8B), the filling port 91 and the filling confirmation port 95 are paired on the rectangular annular resin flow path 8. It is also possible to provide each in three places. In this case, there are six divided flow paths 82a, 82b, 82c, 82d, 82e, and 82f divided by the filling port 91 and the filling confirmation port 95, and six divided flow paths 82a, 82b, 82c, 82d, and 82e. , 82f are designed to have the same volume, the same effect can be expected.

  FIG. 9 shows a blood treatment filter 1C according to the fourth embodiment illustrating the case where the lengths of the divided flow paths 83a, 83b, 83c, and 83d are different, and (a) shows the one from the outer surface 4a side. It is a top view which shows the outline which looked, (b) is sectional drawing along each line of the b1-b1 line | wire, b2-b2 line | wire, b3-b3 line | wire, and b4-b4 line | wire of (a) figure.

  In the blood processing filter 1C according to the fourth embodiment, when the plurality of divided flow paths 83a, 83b, 83c, 83d extending from the filling ports 91a, 91b to the filling confirmation ports 95a, 95b have different lengths, By changing the inner diameters of the paths 83a, 83b, 83c, and 83d, the volumes of the divided flow paths 83a, 83b, 83c, and 83d are made substantially the same, and the arrival time of the molten resin 6 is controlled.

  Specifically, in the blood processing filter 1C according to the fourth embodiment, two (plural) filling ports 91a and 91b and two (plural) filling confirmation ports 95a, 95b. Of the two (plural) filling ports 91a and 95b, the distances Lx of the divided flow paths 83a and 83d from the first filling port 91a to the first and second filling confirmation ports 95a and 95b are the same. The distance La from the second filling port 91b to the first filling confirmation port 95a is shorter than the distance (2Lx−La) from the second filling port 91b to the second filling confirmation port 95b. However, the inner diameter da of the divided flow path 83b from the second filling port 91b to the first filling confirmation port 95a is equal to the inner diameter db of the divided flow path 83c from the second filling port 91b to the second filling confirmation port 95b. It is larger than the inner diameter dx of the divided flow paths 83a and 83d from the first filling port 91 to the first and second filling confirmation ports 95a and 95b. The inner diameter db of the divided flow path 83c is smaller than the inner diameter dx of the divided flow paths 83a and 83d. As a result, the volumes of the divided flow paths 83a, 83b, 83c, and 83d are adjusted to be substantially the same.

  FIG. 10 shows a blood treatment filter 1D according to the fifth embodiment exemplifying the case where the lengths of the divided flow paths 84a, 84b, 84c, and 84d are different, and (a) shows from the one outer surface 4a side. It is a top view which shows the outline which looked, (b) is sectional drawing along each line of the b1-b1 line of FIG.

  In the blood processing filter 1D according to the fifth embodiment, when the lengths of the plurality of divided flow paths 84a and 84d extending from the filling port 91c to the filling confirmation ports 95c and 95d are different, a plurality of filling ports 91c and 91d are provided. It is assumed that the arrival time of the molten resin 6 is controlled by changing the inner diameters dm and dn.

  Specifically, in the blood treatment filter 1D according to the fifth embodiment, two (plural) filling ports 91c, 91d and two (plural) filling confirmation ports 95c, 95d. Of the two (plural) filling ports 91c and 91d, the distances of the divided flow paths 84a and 84d from the first filling port 91c to the first and second filling confirmation ports 95c and 95d are the same, and the second The distances of the divided flow paths 84b and 84c from the first filling port 91d to the first and second filling confirmation ports 95c and 95d are the same. However, the distances of the divided flow paths 84a and 84d from the first filling port 91c to the first and second filling confirmation ports 95c and 95d are the same as the distances from the second filling port 91d to the first and second filling confirmation ports 95c. , 95d is shorter than the distance of the divided flow paths 84b, 84c.

  Here, the inner diameter dm of the second path communicating with the resin flow path 8 from the second filling port 91d is larger than the inner diameter dm of the first path communicating with the resin flow path 8 from the first filling port 91c. . As a result, it is possible to substantially increase the amount (flow rate) of the molten resin 6 filled per unit time from the second path. Therefore, even when the lengths of the divided flow paths 84b and 84c are longer than the divided flow paths 84a and 84d, the arrival time to the filling confirmation ports 95c and 95d can be shortened, and the melting from the filling ports 91c and 91d is achieved. Filling of the resin 6 can be started at the same timing, and it can be assumed that the blood processing filter 1D reaches the filling confirmation ports 95c and 95d at the same timing.

  In each of the above-described embodiments, the divided flow paths 8a to 8d, 81a, 81b, 82a to 82d, 83a to 83d, and 84a to 84d are adjusted to adjust the volume etc., and the molten resin 6 is filled with the filling ports 91, 91a, The mode of controlling the time to reach the filling confirmation ports 95, 95a, 95b, 95c, and 95d from 91b, 91c, and 91d has been exemplified. For example, the same effect can be obtained by shifting the timing of filling the molten resin 6 It is also possible.

  FIGS. 11A and 11B are diagrams for explaining a mode in which the timing of filling the molten resin 6 is shifted. FIG. 11A shows the blood processing filter 1 according to the first embodiment, and FIG. 11B shows the sixth embodiment. The blood processing filter 1E which concerns on is shown.

  In the blood processing filter 1E according to the sixth embodiment, two (plural) filling ports 91e, 91f and two (plural) filling confirmation ports 95e, 95f are provided on the rectangular annular resin flow path 8. It has been. Of the two (plurality) of filling ports 91e and 91f, the length of the divided flow paths 85a and 85d from the first filling port 91e to the first and second filling confirmation ports 95e and 95f The lengths of the divided flow paths 85b and 85c from the filling port 91f to the first and second filling confirmation ports 95e and 95f are longer. Accordingly, the longer divided flow paths 85b and 85c have a larger volume than the shorter divided flow paths 85a and 85d. Therefore, the molten resin 6 is fed from the first and second filling ports 91e and 91f at the same timing. When filling is started, the molten resin 6 filled from the second filling port 91f reaches the first and second filling confirmation ports 95e and 95f at the timing when the molten resin 6 filled from the first filling port 91e is first. 1 and later than the timing of reaching the second filling confirmation ports 95e and 95f.

  Therefore, the timing for starting filling from the second filling port 91e by the delay amount is determined in advance and the gate opening time of the resin injection port of the apparatus for injecting the molten resin 6 is adjusted. Is adjusted so that the timing at which the molten resin 6 filled from both the first and second filling ports 91e and 91f reaches the first and second filling confirmation ports 95e and 95f is aligned.

  Further, the outer shape of the blood processing filters 1 and 1A to 1E according to each of the above embodiments is not limited to a square shape or the like, and various shapes can be adopted as shown in FIG. For example, FIG. 12 (a) shows an aspect in which the outer shape is a triangle, (b) shows an aspect in which the outer shape is a pentagon, (c) shows an aspect in which the outer shape is a hexagon, and (d) shows an aspect in which the outer shape is a heptagon. A mode is shown, (e) shows an aspect with an octagonal outer shape, and (f) shows an aspect with an octagonal outer shape.

  The blood processing filters 1 and 1A to 1E according to each embodiment have been described above. Each of these aspects can be appropriately selected in consideration of the product size, required performance, manufacturing efficiency, or the like, but the following explanation can be given as consideration of each element.

  For example, the resin flow path 8 preferably has a uniform cross-sectional area in consideration of mold processability and moldability. The filling ports 91, 91a to 91f (hereinafter, representatively referred to as “filling port 91”) and the filling confirmation ports 95, 95a to 95f (hereinafter, representatively referred to as “filling confirmation port 95”) are resin flow paths. If the volume of the resin flow path 8 between the adjacent filling port 91 and the filling confirmation port 95 is constant, the filling port 91 and the filling confirmation port in the resin flow path 8 are arranged alternately. The volumes of the plurality of divided flow paths 8a to 8d, 81a, 81b, 82a to 82d, and 83a to 83d divided by 95 are the same. As a result, complicated control for aligning the timing at which the molten resin 6 filled from each filling port 91 reaches each filling confirmation port 95 becomes unnecessary, which is preferable.

  The filling port 91 and the filling confirmation port 95 are preferably paired, and in particular, two pairs (two filling ports 91, two filling ports 91, one filling port 91, one filling confirmation port 95), Two filling confirmation ports 95) are preferable. The smaller the number of filling ports 91 and the filling confirmation ports 95, the simpler the structure becomes. On the other hand, the longer the length of the resin flow path 8 (divided flow path), the longer the filling confirmation ports 95 to the respective filling confirmation ports 95. Since the arrival time of the molten resin 6 that reaches is easily varied, the volumes of the divided flow paths 8a to 8d, 81a, 81b, 82a to 82d, 83a to 83d, 84a to 84d, and 85a to 85d are appropriate. In addition, it is necessary to determine the number and arrangement of the filling port 91 and the filling confirmation port 95.

  The filling port 91 and the filling confirmation port 95 are preferably provided so as to avoid the inlet port 4 c of the inlet side container material 4 and the outlet port 5 c of the outlet side container material 5. The inlet port 4c and the outlet port 5c are formed with internal flow paths communicating with the internal space 3s of the rigid container 3, so that the filling port 91 and the filling confirmation port 95 can be formed while avoiding these internal flow paths. This is because it is difficult and the structure tends to be complicated. Note that avoiding the inlet port 4c and the outlet port 5c means that when the filling port 91 and the filling confirmation port 95 are provided on the inlet side container material 4 side, they are provided so as not to overlap the inlet port 4c in plan view. When the filling port 91 and the filling confirmation port 95 are provided on the outlet side container material 5 side, it means that they are provided so as not to overlap the outlet port 5c in plan view.

  One or a plurality of filling ports 91 can be provided for one resin flow path 8, and one or a plurality of filling confirmation ports 95 can be provided. By providing the plurality of filling ports 91, the filling efficiency of the molten resin 6 can be improved, and by providing the plurality of filling confirmation ports 95, it becomes easy to check the filling state in the resin flow path 8.

  Here, in particular, when a plurality of filling confirmation ports 95 are provided for one resin flow path 8, the divided flow paths 8 a to 8 d, 81 a that connect the plurality of filling confirmation openings 95 and the filling openings 91, respectively. , 81b, 82a to 82d, 83a to 83d are preferably formed to have the same volume. Note that, as described above in the fifth and sixth embodiments, when a plurality of filling ports 91c to 91f are formed for one resin flow path 8, the divided flow paths 84a to 84d and 85a to 85d are provided. If the volumes of the filling ports are different, it is necessary to make adjustments such that the inner diameters of the filling ports 91c and 91d are different or the filling start timing of the molten resin 6 from the filling ports 91e and 91f is shifted.

  Moreover, the several filling confirmation port 95 may be provided in both the inlet side container material 4 and the outlet side container material 5, and may be provided collectively in either one. In the case where both are provided, when it is necessary to avoid the inlet port 4c and the outlet port 5c, the number of candidates as the place where the filling confirmation port 95 can be formed increases, and it is easy to form the optimum place. On the other hand, if they are provided together in either one, it is sufficient to check only one side surface of the blood processing filters 1 and 1A to 1E where the filling confirmation port 95 is provided at the time of the leak test. In each case, it is preferable to save the trouble of turning over.

  Moreover, the some filling port 91 may be provided in both the inlet side container material 4 and the outlet side container material 5, and may be provided collectively in either one. In the case where both are provided, if it is necessary to avoid the inlet port 4c and the outlet port 5c, the number of candidates as the place where the filling port 91 can be formed increases, and it becomes easy to form the optimum place. On the other hand, when the molten resin 6 is provided together, the molten resin 6 is filled only from one side surface provided with the filling port 91 when the molten resin 6 is filled. This makes it possible to simplify the structure and control of the apparatus for filling the container.

  Further, when at least one of the filling confirmation port 95 and the filling port 91 is provided, a plurality of filling confirmation ports 95 or filling ports 91 are provided over the entire circumference along the end surface 2c of the filter element 2. If it arrange | positions along 8 at equal intervals, a bias | bias will disappear and suitable filling of the molten resin 6 and the confirmation by visual observation are attained, and it is suitable.

  Moreover, when the shape of the blood processing filters 1 and 1A to 1E is a polygonal shape, when the filling port 91 or the filling confirmation port 95 is arranged at each corner, the divided flow paths 8a to 8d and the like extend along each side of the polygonal shape. Since it becomes a straight line, the flow of the molten resin 6 is easily adjusted in each of the divided flow paths 8a to 8d, etc., and it becomes difficult for the timing to reach the filling confirmation port 95 to vary, and whether or not the molten resin 6 is properly filled. This is preferable because it increases the reliability of the determination.

  Next, a method for manufacturing the blood processing filters 1 and 1A to 1E according to each of the above embodiments will be described. In addition, since the manufacturing method of the blood processing filter 1, 1A-1E which concerns on each embodiment is fundamentally the same, an example of a manufacturing method is assumed supposing the blood processing filter 1. FIG. First, the injection molding machine 10 used in this manufacturing method will be described.

  As shown in FIG. 14, the injection molding machine 10 includes a fixed mold 11, a movable mold (mold) 12, and a slide moving mold (mold) 13. The fixed mold 11 is fixed to a fixed plate (not shown) of the injection molding machine 10. On the upper surface of the fixed mold 11, a mount 15 having a sliding cylinder 14 is installed. A cylinder 14 operated by hydraulic pressure or air pressure is connected to the upper surface of the slide moving mold 13. The slide moving die 13 can be slid up and down while maintaining a state of being in close contact with the side surface of the fixed die 11.

  The movable mold 12 is attached to a movable plate (not shown) that is horizontally movable on the injection molding machine 10. The movable plate can be moved close to and away from the fixed mold 11 by a mold opening / closing device (not shown) of the injection molding machine 10. The movable mold 12 can be moved between a mold closing position in close contact with the slide moving mold 13 and a mold opening position away from the slide moving mold 13.

  The fixed mold 11 is provided with a sprue 11 a at the center thereof for guiding the molten resin 16 injected from an injection machine (not shown) attached to the fixed mold 11. The slide moving mold 13 is provided with a central sub sprue 13a that is continuous with the sprue 11a when it is in the lower position, and a lower sub sprue 13b that is continuous with the sprue 11a when it is moved to the upper position.

  On the mold closing surface of the slide moving mold 13, a male mold 13c and a female mold 13d are provided at symmetrical positions above and below the central sub sprue 13a. The male mold 13 c is for molding the inner surface 4 b of the inlet side container material 4, and the female mold 13 d is for molding the outer surface 5 a of the outlet side container material 5. On the other hand, the mold closing surface of the movable mold 12 is provided with a female mold 12c and a male mold 12d that face the male mold 13c and the female mold 13d, respectively, when the slide moving mold 13 is in the lower position.

  The female mold 12c of the movable mold 12 is for molding the outer surface 4a (see FIG. 4) of the inlet side container material 4, and the male mold 12d is for molding the inner surface 5b of the outlet side container material 5. And this female type | mold 12c (refer FIG. 15, FIG. 16) is made to oppose the female type | mold 13d by the side of the slide movement type | mold 13 when the slide movement type | mold 13 exists in an upper position.

  As shown in FIG. 14, when the slide movable mold 13 is in the lower position and the movable mold 12 is closed, the male mold 12 d, between the slide movable mold 13 and the movable mold 12, A pair of gaps 17 and 18 surrounded by 13c and the respective female molds 13d and 12c are formed. At this time, the central sub-sprue 13a of the slide moving mold 13 is communicated with these gaps from the end edges of the female molds 13d and 12c through the runner 12e and the pair of gates 12f formed on the movable mold 12. Yes.

  Further, as shown in FIG. 16, when the slide moving mold 13 is in the upper position and the movable mold 12 is aligned with this, the female molds 13d and 12c of the slide moving mold 13 and the movable mold 12 are They are butted against each other. In this state, holes (not shown) communicating with the lower sub sprue 13b and the runner 12e through the gate 12f are formed at the end edges of the female dies 13d and 12c. This hole communicates with the filling port 91 formed in the outlet side container material 5 or the inlet side container material 4 and is provided for filling the resin flow path 8 with the molten resin 16 (molten resin 6). Yes.

  In order to mold the blood processing filter 1 using the injection molding machine 10, first, as shown in FIG. 14, the cylinder 14 is extended and the slide movable die 13 is positioned at the lower position. Then, the movable platen of the injection molding machine 10 is moved to the fixed platen side, and the slide moving mold 13 and the movable mold 12 are closed. In this state, the sub sprue 13a at the center of the slide moving mold 13 is continuous with the sprue 11a of the fixed mold 11, and a pair of gaps 17 and 18 are formed between the slide moving mold 13 and the movable mold 12.

  Next, the molten resin 16 is injected from an injection machine attached to the fixed platen, and into the gaps 17 and 18 through the sprue 11a of the fixed mold 11, the sub sprue 13a at the center of the slide moving mold 13, the runner 12e and the gate 12f. The molten resin 16 is guided and filled in the voids 17 and 18. Thus, a pair of male and female inlet-side container members 4 and outlet-side container members 5 are formed in the gaps 17 and 18 (container material forming step).

  After cooling and solidifying the pair of male and female inlet side container members 4 and outlet side container member 5, the movable mold 12 and the slide movable mold 13 are opened and separated by a mold opening and closing device as shown in FIG. Then, the male molds 13c and 12d are detached from the inlet side container material 4 and the outlet side container material 5, and the inlet side container material 4 and the outlet side container material 5 remain on the female molds 12c and 13s side, respectively. When the mold is opened, the resin portion solidified in the mold sprue 11a, sub sprue 13a, runner 12e, gate 12f, etc. is projected from the mold and dropped. The inlet-side container material 4 and the outlet-side container material 5 obtained in this way are provided with an inlet-side joint portion 4d and an outlet-side joint portion 5d along the inner edge of the rectangular shape. In the (joining step), the inlet side joint 4d and the outlet side joint 5d are abutted with each other to form the joint 7.

  Next, as shown in FIG. 15, after inserting the filter element 2 made of polyester nonwoven fabric into the outlet side container material 5, the cylinder 14 is contracted, and the slide movable die 13 is moved to the upper position (loading step). . Then, the female mold 13d of the slide moving mold 13 and the female mold 12c of the movable mold 12 face each other, and the inlet side container material 4 and the outlet side container material 5 left in these female molds 13d, 12c face each other. It becomes. At this time, the sub sprue 13 b below the slide moving mold 13 is positioned so as to be continuous with the sprue 11 a of the fixed mold 11.

  In this state, the movable mold 12 is moved to the slide movable mold 13 side, and these are brought into contact with each other and closed as shown in FIG. Then, the abutting surfaces of the inlet side joint portion 4d and the outlet side joint portion 5d are abutted with each other, and a hollow resin flow path 8 is formed by the groove 4x and the groove 5x (see FIG. 4) of the sliding contact portion 7a (see FIG. 4). Joining process).

  The resin flow path 8 communicates with the gate 12f through the filling port 91 and the filling confirmation port 95, and the gate 12f further communicates with the sub sprue 13b through the runner 12e. In this state, the molten resin 16 is injected from the injection machine as the molten resin 6 (see FIG. 3) filled in the resin flow path 8. Then, the molten resin 16 passes through the sprue 11a, the sub sprue 13b, the runner 12e, the gate 12f, and the filling port 91 of the fixed mold 11, and is filled into the resin flow path 8 as the molten resin 6. As a result, the inlet side container material 4 and the outlet side container material 5 are welded to each other at the periphery of the joint 7 by the molten resin 6 (adhering step). Thus, according to the method of filling the molten resin 6 after forming the resin flow path 8, the resin amount can be easily controlled.

  After the molten resin 6 is cooled and solidified, when the mold opening / closing device is used to open the slide moving mold 13 and the movable mold 12 again, the inlet side container material 4 and the outlet side container material 5 are fitted and bonded, and a completely sealed molded product. As a result, the completed blood treatment filter 1 is obtained. The resin portion solidified in the sprue 11a, the sub sprue 13b, the runner 12e, the gate 12f, and the like is protruded from the mold and dropped.

  After removing the blood treatment filter 1 thus completed, the cylinder 14 is extended again, and the slide movable die 13 is positioned at the lower position. Then, the movable mold 12 and the slide moving mold 13 are closed, and the process proceeds to the molding process for the next product. And the blood processing filter 1 can be shape | molded continuously by repeating the above series of processes. Moreover, the molding process is composed of simple processes such as vertical slide of the slide mold 13, mold closing and mold opening by moving the movable mold 12 back and forth (horizontal), and injection of the molten resin 16. Automation can also be easily performed. Therefore, mass production of the blood processing filter 1 becomes possible.

  Thus, the interior of the filter element 2 can be changed from the injection molding of the inlet side container material 4 and the outlet side container material 5 only by using the movable mold 12, which is a set of molds, and the slide moving mold 13 and the injection molding machine 10. Up to the bonding of the inlet-side container material 4 and the outlet-side container material 5, which are male and female container materials, can be continuously performed in a single process, and even a completely sealed one can be molded.

  Next, the leak inspection method according to each embodiment will be described. After manufacturing the blood processing filters 1 and 1A to 1E according to each embodiment by the above manufacturing method, the filling confirmation ports 95 and 95a to 95f formed in the hard containers 3 of the blood processing filters 1 and 1A to 1E are visually observed. Confirm with. As a result, when the molten resin 6 can be confirmed from the filling confirmation ports 95, 95a to 95f, the liquid tightness of the joint portion 7 of the inlet side container material 4 and the outlet side container material 5 is high, that is, a good product. Can be confirmed. Conversely, when the molten resin 6 cannot be confirmed from the filling confirmation port 95, it can be confirmed that the blood processing filters 1, 1A to 1E have low liquid-tightness of the joint portion 7, that is, are defective.

  As described above, in the blood processing filters 1 and 1A to 1E according to each embodiment, the molten resin 6 is filled into the resin flow path 8 from the filling ports 91 and 91a to 91f, and the inlet side container material 4 and the outlet side container material 5 are filled. The joint portion 7 is joined. Here, when the molten resin 6 filled from the filling ports 91 and 91a to 91f reaches the filling confirmation ports 95 and 95a to 95f, the filling state of the molten resin 6 is visually confirmed from the filling confirmation ports 95 and 95a to 95f. As a result, it can be confirmed that the molten resin 6 is filled in the resin flow path 8 between the filling ports 91 and 91a to 91f and the filling confirmation ports 95 and 95a to 95f. On the contrary, if the molten resin 6 cannot be confirmed from the filling confirmation ports 95 and 95a to 95f, it can be determined that the leakage filter has a possibility of leakage, and the leakage filter can be easily selected and eliminated.

  DESCRIPTION OF SYMBOLS 1,1A-1E ... Blood processing filter, 2 ... Filter element, 4 ... Inlet side container material, 4a ... Outer surface of inlet side container material, 4c ... Inlet port, 4d ... Inlet side joint part, 5 ... Outlet side container material 5a ... Outer surface of outlet side container material, 5c ... Outlet port, 5d ... Outlet side joint, 7 ... Joint, 8 ... Resin channel, 8a-8d, 81a, 81b, 82a-82f, 83a-83d, 84a to 84d, 85a to 85d ... split flow path, 12 ... movable mold (mold), 13 ... slide moving mold (mold), 91, 91a-91f ... filling port, 95, 95a-95f ... filling confirmation port.

Claims (14)

A filter for filtering liquid,
A filter element, and an inlet side container material and an outlet side container material arranged with the filter element interposed therebetween,
The internal space formed by the inlet side container material and the outlet side container material is partitioned into the inlet space and the outlet space by the filter element,
The filter element has a filtration surface on the inlet space side and a filtration surface on the outlet space side, and end surfaces along the peripheral edges of the pair of filtration surfaces,
The inlet-side container material and the outlet-side container material have a joint part that surrounds and joins the end face of the filter element,
The joint portion includes an inlet-side joint portion provided in the inlet-side container material, an outlet-side joint portion provided in the outlet-side container material, and contact between the inlet-side joint portion and the outlet-side joint portion. A resin flow path of molten resin provided in the part,
The inlet side container material and the outlet side container material are bonded by the molten resin filled in the resin flow path,
At least one of the outer surface of the inlet side container material and the outer surface of the outlet side container material is provided with a filling port filled with the molten resin,
A filter in which at least one of the outer surface of the inlet-side container material and the outer surface of the outlet-side container material is provided with a filling confirmation port connected to the filling port via the resin flow path.   The filter according to claim 1, wherein the inlet side joint and the outlet side joint are fitted to each other.   The resin flow path is provided over the entire circumference along the end surface of the filter element, and the inlet side joint and the outlet side joint are bonded by the molten resin filled in the resin flow path. The filter according to claim 1 or 2, wherein The inlet side container material has an inlet port into which the liquid is introduced, and the outlet side container material has an outlet port through which the liquid is discharged;
The filter according to any one of claims 1 to 3, wherein at least one of the filling port and the filling confirmation port is provided to avoid the inlet port and the outlet port.   The filter according to claim 4, wherein both the filling port and the filling confirmation port are provided to avoid the inlet port and the outlet port.   The filter according to any one of claims 1 to 5, wherein a plurality of the filling confirmation ports are provided for one resin flow path.   The filter according to claim 6, wherein the plurality of filling confirmation ports are formed in both the inlet side container material and the outlet side container material.   The filter according to claim 1, wherein a plurality of the filling ports are provided for one resin flow path.   The filter according to claim 8, wherein the plurality of filling ports are collectively provided in the inlet-side container material or the outlet-side container material.   The filling port and the filling confirmation port are alternately arranged along the resin flow channel, and the volume of a plurality of divided flow channels divided by the filling port and the filling confirmation port in the resin flow channel The filter according to claim 1, wherein are the same.   The at least one of the said filling confirmation port and the said filling port is provided with two or more, and is arrange | positioned at equal intervals along the said resin flow path provided over the perimeter along the said end surface of the said filter element. The filter described. A filter for filtering a liquid, comprising a filter element, and an inlet-side container material and an outlet-side container material arranged with the filter element interposed therebetween, and is formed by an inlet-side container material and an outlet-side container material The internal space is divided into an inlet space and an outlet space by a filter element, and the filter element includes a filtration surface on the inlet space side and a filtration surface on the outlet space side, and end surfaces along the peripheral edges of the pair of filtration surfaces. The inlet-side container material and the outlet-side container material have a joint part that surrounds and joins the end surface of the filter element, and the joint part includes an inlet-side joint part provided on the inlet-side container material, and an outlet side. An outlet side joint provided in the container material, and a resin flow path of molten resin provided in a contact portion between the inlet side joint and the outlet side joint, and the inlet side container material and the outlet side container Equipment is a melt filled in the resin flow path. At least one of the outer surface of the inlet-side container material and the outer surface of the outlet-side container material is provided with a filling port filled with molten resin, and the outer surface of the inlet-side container material and the outlet-side container material At least one of the outer surfaces of the filter is provided with a filling confirmation port connected to the filling port through a resin flow path,
A container material molding step of injection molding the inlet side container material with one mold and the outlet side container material with the other mold;
A loading step of loading the inlet side container material or the outlet side container material with a filter element;
A joining step of abutting the inlet side container material and the outlet side container material with the filter element loaded;
An adhering step of filling the resin flow path provided at a joint between the inlet-side container material and the outlet-side container material with the molten resin and bonding the inlet-side container material and the outlet-side container material; With
In the fixing process, the molten resin is filled from the filling port.   In the joining step, a pair of the molds are matched and the filter element is sandwiched between the inlet-side container material and the outlet-side container material, and in this state, the inlet-side joint portion and the outlet-side joint The manufacturing method of the filter of Claim 12 which fits a part. A filter leak inspection method for filtering liquid,
The filter includes a filter element, an inlet side container material and an outlet side container material arranged with the filter element interposed therebetween, and an internal space formed by the inlet side container material and the outlet side container material is: The filter element is partitioned into an inlet space and an outlet space, and the filter element includes a filtration surface on the inlet space side and a filtration surface on the outlet space side, and end surfaces along the periphery of the pair of filtration surfaces, The inlet-side container material and the outlet-side container material have a joint part that surrounds and joins the end surface of the filter element, and the joint part is an inlet provided in the inlet-side container material. A side joint portion, an outlet side joint portion provided in the outlet side container material, and a resin flow path of a molten resin provided in a contact portion between the inlet side joint portion and the outlet side joint portion. And the entrance side The equipment and the outlet side container material are bonded by the molten resin filled in the resin flow path, and at least one of the outer surface of the inlet side container material and the outer surface of the outlet side container material is melted. A filling port that is filled with a resin is provided, and at least one of the outer surface of the inlet side container material and the outer surface of the outlet side container material is filled with the filling port via the resin flow path There is a mouth,
A method for inspecting a leak of a filter, wherein the molten resin is confirmed from the filling confirmation port to confirm that the liquid tightness of the joint portion of the inlet side container material and the outlet side container material is high.

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