JP2016023169A - Method for producing pancreatic tumor development-inhibiting composition, the composition, as well as koji production method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a method for producing a pancreatic tumor development-inhibiting composition with high physiological activity, and high pancreatic tumor development-inhibiting effect when ingesting as a food.SOLUTION: The invention relates to a method for producing a pancreatic tumor development-inhibiting composition comprising: polishing unpolished rice in a rice-polishing machine until 96% or more of a rice polishing rate and hydrating this polished rice; making a hydrated mixture of rice bran and a calcium compound in a mixer separately; mixing and steaming the hydrated polished rice and the hydrated mixture, and inoculating seed aspergillus into a culture bed so as to germinate; stirring a substrate to radiate heat generated with fermentation, and maintaining in a suitable temperature; drying a matured koji until 4% or less of water content in a temperature of goods of the substrate; and powdering in a condition where enzyme activity is maintained.SELECTED DRAWING: None

Description

  The present invention relates to a method for producing a composition excellent in suppressing the onset of pancreatic tumors, a composition for suppressing the onset of pancreatic tumors, and a method for producing sputum.

For example, Patent Document 1 discloses a composition that has an effect of suppressing the onset of colorectal cancer tumors.
Patent Document 2 describes that the brown rice surface is damaged.

JP 2002-272414 A

JP 2009-45013 A

The invention described in Patent Document 1 is a mixture of non-heated dietary fiber powder with cereal meal fine powder. Since dietary fiber moves while rubbing the intestinal wall, it has an action of including and removing a colorectal cancer onset-causing substance, and the compound described in Patent Document 1 has an excellent effect. Is.
However, in this patent document 1, there is no description regarding making brown rice water easily.
In the invention of Patent Document 2, brown rice is put into a mixer, and a deep cut reaching the endosperm from the epidermis is made by a rotating blade of the mixer. This takes too much labor, spots, and cracks. There are problems such as deteriorating the appearance, and there is a difficulty that it is difficult to put on a commercial base.
On the other hand, pancreatic tumor is a typical refractory cancer that frequently occurs among Japanese cancer deaths. It develops in a specific place where surgery is difficult and early detection is difficult and progresses quickly. Moreover, the prognosis is extremely bad. Therefore, establishment of an effective prevention method is eagerly desired.
According to statistics, there are more than 22,000 deaths from pancreatic cancer in Japan every year, and it is increasing year by year.
Risk factors for the development of pancreatic cancer include smoking, obesity, diabetes, and hereditary pancreatic cancer syndrome. The National Cancer Institute of the United States said, “B-type people are about 1.7 times more blood-type people, AB "Type people are about 1.5 times more likely to get pancreatic cancer than people who are type A, about 1.3 times," suggesting that they are hereditary.
In addition, Harvard University has announced that people with blood type O are less prone to thrombosis, suggesting that hyperlipidemia and blood flow disorders that cause thrombosis are one of the causes of cancer. doing.
The inventors of the present invention have found that they have an inhibitory effect on tumors from many years of research on brown rice fermented foods manufactured by the patent applicant company, and have further completed research at university medical departments etc. to complete the present invention. It came to do.

  The specific contents of the present invention are as follows.

  (1) A process of milling brown rice into a milled brown rice with a milling ratio of 96% or more, a process of adding water to the milled brown rice, a process of making a water mixture of rice bran and a calcium compound with a blender, , Mixing the steamed brown rice with water and the water mixture, steaming, inoculating the seed bacilli and germinating in the culture bed, and automatically measuring the fermentation heat to stir the substrate and dissipate the heat. And after the maturation of the koji, the moisture content of the substrate of the culture bed is dried to 4% or less to make the powder while maintaining the enzyme activity, and if necessary, another composite functional material powder is added. The manufacturing method of the pancreatic tumor onset suppression composition including the process to mix.

  (2) The said rice mill is a grinding type manufacturing method of the pancreatic tumor onset suppression composition as described in said (1).

  (3) The polishing of the pancreatic tumor occurrence according to (1) or (2) above, wherein the milling by the rice milling machine is equal-thickness polished rice having a grinding degree in the thickness direction larger than that in the length direction. Production method.

  (4) A pancreatic tumor onset suppressing composition produced by the method according to any one of (1) to (3).

  (5) A method for producing rice bran, in which brown rice is refined with a rice milling machine to a milled rice ratio of 96% or more to make chopped brown rice, which is then hydrated, steamed, inoculated with a koji mold and fermented on a culture bed.

  According to the present invention, the following effects can be obtained.

According to the invention described in (1) above, the brown rice is refined to a polishing rate of 96% or more with a rice mill, so that the surface of the milled brown rice has numerous fine scratches. If this browned rice is hydrated in a container, it will be sufficiently hydrated faster than ordinary brown rice soaked in water, the workability will be improved, and it will be easier to steam in the next steaming step.
Moreover, since the rice bran and the hydrated mixture of a calcium compound and steamed brown rice containing water are steamed together, the brown rice which is hard to be water-containing is sufficiently water-containing.
Therefore, when steamed brown rice in this state is steamed, fine cracks are generated in the skin of the cut brown rice, and when it is loaded on the culture bed and cultivation of the koji mold begins, the koji mold is removed from the cracks on the surface of the cut brown rice. Since it is easy to enter the inside of the cut brown rice, the fungus is actively propagated throughout the cut brown rice.
Fermentation heat is generated along with the fermentation, but since it is stirred as necessary by automatic temperature measurement, it is radiated and does not hinder the growth of koji mold.
Therefore, the gonococcus is vigorously propagated inside the chopped brown rice, the amount of enzyme contained is increased, and a composition having a high enzyme activity is produced.
The finished cocoon has excellent storage stability due to its low water content, and when it is made into a powder composition, it is maintained in a neutral to weakly acidic region with a pH of 5.5 to 6.5, has a high enzymatic power, and has a SOD elimination activity. A stable composition is obtained.
The added composite functional material contributes to the activation of body tissue cells because the specific components contained in the composite functional material act in a complex and synergistic manner.
Therefore, it is possible to obtain a pancreatic tumor onset suppressing composition that can be taken as a health supplement and that has an enzyme-stable activity.

  In the invention described in (2), since the rice mill is of a grinding type, scratches caused by the abrasive grains of the grinding wheel are formed on the grinding surface, and it is easy to contain water from the grinding surface. Easy to enter.

In the invention described in the above (3), the milling by the rice milling machine is, for example, increasing the rotational speed of the Kongo roll and adjusting the resistance pressure at the outlet to make equal thickness milled rice. The degree of grinding in the thickness direction is greater than the degree of grinding, and the entire surface can be ground on average, so when steamed, cracks in the thickness direction occur on average, and the gonococcus is contained in the culture bed. It is possible to breed on average, and to obtain the average browned rice bran within a certain time.
In particular, when fermenting with rice bran instead of brown rice alone, fermentation of large grained brown rice does not slow down and can be made into rice cake with rice bran.

  In the invention described in (4) above, the pancreatic tumor onset suppressing composition produced by the method described in any one of (1) to (3) above, wherein nutrients in rice bran of chopped brown rice, It contains abundant enzymes that are different from the above, and excellent nutrients in the composite functional material, and has excellent ingredients as health supplements.

In the invention described in the above (5), since the brown rice is hydrated with a rice milling ratio of 96% or more as, for example, equal-thickness rice by a rice mill, the outer layer of the hard epidermis is ground and can be hydrated in a short time. Excellent workability.
In addition, when steamed, uniform cracks are formed as a whole, and the koji molds propagate from the surface into the inside on average during fermentation, and can obtain koji without spots.

It is a histopathological image of a pancreatic proliferative lesion. It is a table | surface which shows the number of hamsters with a pancreatic duct proliferative lesion. It is a graph of the number of tumors in the pancreatic duct per animal. It is a graph of the number of pancreatic duct cancers per animal.

Hereinafter, the present invention will be described with reference to examples. The pancreatic tumor onset suppressing composition is a composition based on a koji mold fermentation composition that significantly has physiological activity.
The substrate is selected from cereals such as rice, wheat, rice bran, etc., with any combination. Rice bran usually contains around 34% germ. In addition, depending on the rating of the cocoon, a large amount of endosperm is also mixed.
The amount of water added to rice bran is 25 w% to 30 w%, and a smaller amount is preferable for koji mold culture.

As cereals, brown rice, wheat, rice bran, rice bran, etc. are arbitrarily selected according to the purpose. The ratio of rice bran and cereal is arbitrarily selected from 5 to 95 w% of cereal with respect to 5 to 95 w% of rice bran.
Aside from rice bran, cereals are swollen in advance as necessary and mixed with watered rice bran before steaming. Rice bran is automatically put into the water machine at the same time as water, mixed at high speed and discharged. The amount of water is 25 to 30% by weight, and a smaller amount is preferable.

When brown rice is used, it is crushed brown rice with less peeling of the epidermis than quince rice by scouring in advance so that the rice polishing ratio is 96% or more.
For example, in the case of a vertical grinding-type rice milling machine, the milling speed is increased by increasing the rotational speed of the metal-rigid roll, which is a rotating grindstone, and adjusting the resistance pressure of the outlet lid with a weight to make the entire thickness average. . Brown rice that comes in contact with the Kongo roll with a high rotational speed is ground in the thickness direction more than in the length direction.

The whole of the cut brown rice is easily hydrated when the cut brown rice is immersed in water because the entire surface of the cut brown rice is scratched by the abrasive grains protruding from the grinding stone of the rugged roll.
In addition, when steamed, many cracks are formed on the surface in the thickness direction, and on the culture bed, gonococcal bacteria averagely enter and propagate inside, and in a short time, there are no spots and good appearance of the cut brown rice You can get firewood. In particular, when fermenting with rice bran in a fermenter, only brown rice with large grains does not slow down the koji mold fermentation.

  The water in which the brown rice is immersed preferably has a high osmotic pressure. For example, if necessary, a weak saline solution in which salt is added in an amount of 0.2 to 0.3% with respect to water will soften the epidermis quickly. In that case, if necessary, soak the salt with fresh water.

  Separately from brown rice, rice bran is mixed with calcium powder with a water mixer, and the water-containing cut brown rice is put into a steamer and steamed by a conventional method. Other cereals are also hydrated and swollen separately from rice bran. The calcium compound is selected from, for example, calcium lactate, calcium carbonate, and other calcium compounds, and the calcium content is selected from about 300 mg to about 1000 mg as necessary with respect to 100 g of the substrate.

  The steamed substrate is cooled to a suitable temperature that does not interfere with the koji mold, and the koji mold is inoculated uniformly, spread on the culture bed of a sealed rotary drum type automatic temperature and humidity control fermenter, and allowed to stand for about 8 hours. And encourage germination under humidity control.

The surface of rice bran skin is around 1mm, and the amount of water is low, so there is no close contact between substrates due to water, and even if rice bran is in contact with each other, a large space is maintained against fine bacilli. As a result, gonococci breed actively.
When chopping brown rice by itself, moisten it, steam it alone and knead it in the usual way.

  During fermentation, the product temperature increases due to fermentation heat, but when the product temperature reaches about 42 ° C, the culture bed automatically rotates, the entire substrate is stirred and radiated without flaking, and fresh air blown from the outside Fully exposed. The culture bed rotates automatically and stirs the substrate of the culture bed so that it is constantly dissipated, fresh air is supplied, and the temperature and humidity are automatically adjusted to maintain an optimal environment for the growth of Aspergillus oryzae. Is done.

When a preset time has elapsed, the culture bed of the fermenter stops and the substrate is aged while maintaining the product temperature at 42 ° C. After about 1 hour, the product temperature is maintained at 44 ° C. or lower, and the fermented substrate is dried by the product temperature until the water content is 4% or less, thereby completing the composite koji. The straw was pH 6.5. By this drying step, the enzyme does not deactivate its function as a catalyst.
The above time and temperature are not limited to this.

When this composite koji is pulverized into a fine powder, a pancreatic tumor development inhibiting composition raw powder can be obtained. If necessary, a powdered composite functional material is arbitrarily selected and blended in accordance with the purpose. This is used as a health supplement as powder or as granules or tablets.
The composite functional material is selected from the following, and the ratio is a mixing ratio with respect to the whole. The parenthesis is the main functional ingredient.

Dry shiitake powder (vitamin D) 5-10w%,
3-8w% dry cyanobacteria fine powder (niacin, choline)
Soy protein (fast digestible protein) 10-35w%,

The first blending example is as follows.
Rice bran 93W%,
7w% brown rice,
75% by weight of this mixed composition
Soy protein 22w%,
3% by weight of dried cyanobacteria powder,
A raw composition powder was prepared.

An example of main functional components per 100 g of the composition raw powder is as follows.
◎ 1.96g phosphorus,
◎ 1.91g of potassium,
◎ 3.82g of phytic acid,
◎ Calcium 310mg,
◎ Niacin 39.40mg,
◎ Vitamin E 15.10mg,
◎ Biotin 47.2μg,
◎ SOD erase activity 850 units,
Energy 369kcal.

The blending ratio of cereals as a substrate is
Brown rice 5-95w%,
5 ~ 95w% of rice bran
Is arbitrarily selected from the above to produce a composite koji by koji mold fermentation.

In addition to the above, as the composite functional material, pollen, dried vegetable powder, ganoderma powder, green tea, etc. can be selected, and fermented with koji mold in advance if necessary.
The amount used is about 3 w% to 20 w% with respect to the whole.

Calcium in the human body is excreted as feces and urine, so it must be replenished constantly. The Ministry of Health, Labor and Welfare encourages intake of 700 mg a day (800 mg for the elderly).
Overdose causes hypercalcemia, kidney stones, and milk alkali syndrome (pathological calcification of visceral tissue), so the upper limit of daily tolerance is 2300 mg.
This composition can ingest about 32.5 to 65 mg of calcium in 3 to 6 packs per day in a 3.5 g pack.

  It is well known that calcium is absorbed from the small intestine by synergistic action with vitamin D obtained from fish in normal diets and suppresses bone loss, osteomalacia, ischemic stroke, hypotension, hypertension, etc. Yes.

  Recently, it has been reported to reduce the relative risk of massive cancer. Specifically, 1400-1500 mg calcium supplement and 400 IU vitamin D3 are reported to reduce the relative risk of massive cancer to 0.402%.

  Niacin (vitamin B3) is abundant in cyanobacteria and brown rice, improves blood circulation, lowers blood cholesterol and triglyceride levels, activates digestive system, activates protein, hypertension It is known to have an effect of improving allergy symptoms, suppressing the onset of cancer, and the like.

  The daily required amount of niacin for adults is 17 mg for men and 13 to 15 mg for women. If insufficient, blood flow worsens, resulting in memory problems, depression, dizziness, dyspepsia, diarrhea and the like. There is a high risk of cancer in areas with poor blood flow. In this composition, 40 mg of niacin is contained per 100 g, so that it can be sufficiently ingested.

The recommended daily use of niacin for symptom improvement is as follows:
Manic depressive symptoms 100-500mg,
Mental and physical stress 100-500mg,
Cardiovascular disease 50-500 mg,
Hyperlipidemia 250-500 mg,
Alzheimer's dementia 20-150 mg.

  There are research reports that humans exhibit a cancer prevention effect when ingesting 1-2 g of phytic acid per day. A daily dose of 21 g of this composition contains about 0.76 g of phytic acid. Although this phytic acid is difficult to digest by humans, it can be easily digested because it contains enzymes (phytase, phosphatase) that liberate phosphate from phytic acid and convert it to inositol.

Vitamin E has an action of decomposing active oxygen in the body and an action of activating capillaries to improve blood flow.
In addition, since it activates germ cells, it is greatly involved in cell regeneration, activates immune cells, and suppresses the risk of developing cancer.

  Biotin is a coenzyme for enzymes involved in metabolism. It is contained in yeast, legumes, egg yolk, etc., and is supplied by the intestinal bacterial flora. The estimated daily amount is 45 μg. It is related to protein production and has the effect of activating cells that make the skin and improving blood glucose levels and immune deficiencies.

  Biotin is deficient due to smoking, alcohol, dairy products, raw egg white (more than 10 per day), taking too much antibiotics, etc. When biotin is deficient, insulin secretion is extremely decreased, and when insulin is decreased, a hyperglycemic state is generated, and a large amount of active oxygen is generated in pancreatic β cells, which not only increases the risk of diabetes, but also immunodeficiency, pancreatic The risk of developing tumors is high, and malformations are induced in pregnant women with a high probability.

  Soy is rich in 1 isoflavone polyphenol (C15H10O2). According to a cohort study by the Ministry of Health, Labor and Welfare Research Group, there was a report that there was a correlation that the higher the intake of isoflavone from food, the lower the risk of breast cancer, prostate cancer, cerebral infarction, and myocardial infarction. It is known to inhibit proliferation.

  However, a large intake of isoflavone has an effect of inhibiting iodine uptake into the thyroid, and the upper limit of intake is 75 mg per day. Soy protein is rapidly digested and promotes protein synthesis to activate immune cells.

  Choline (C5H14NO) is a water-soluble essential nutrient that is indispensable for the structure and repair of cell membranes, and activates the functions of the brain and circulatory system. About 100 mg soybeans, about 66 mg cyanobacteria, and about 30 mg brown rice, the recommended daily intake of choline (US designation) is 550 mg.

  Brown rice contains many excellent ingredients, but the ingredients that are exceptionally high are 100 mg of phosphorus 333 mg, potassium 223 mg, magnesium 143 mg, choline 30.7 mg, niacin 5.1 mg, zinc 2.02 mg, selenium 23.4 μg, etc. is there.

Magnesium has a strong reducing action and suppresses active oxygen in the body. In a 70 kg adult, bone tissue and muscle contain about 35 g of magnesium, which is an essential element for energy metabolism.
Deficiency increases the risk of ischemic heart disease, mania, and type II diabetes.

It has been reported that men with high magnesium intake have a lower risk of colorectal cancer (National Cancer Institute), and that the higher the intake of magnesium, the less the inflammatory reaction in the body.
WHO's recommended daily intake of magnesium is 420 mg, and in Japan it is 200-320 mg. It contains 280mg soybeans, 195mg cyanobacteria and 143mg brown rice per 100g.

  Potassium is an indispensable electrolyte for the human body and an element indispensable for information transmission in the brain and nerves. Deficiency increases the risk of high blood pressure, stroke, muscle loss, fatal arrhythmias, and severe dyspnea.

  The standard intake of potassium is 2500 mg per day. An Italian study reported that taking more than 1.46g per day reduced the risk of stroke due to hypertension by 21%. It contains 1797mg soybean and 1363mg cyanobacteria per 100g.

  Phosphorus exists as a polyester chain of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) in the body, ATP (adenosine triphosphate) indispensable for energy metabolism, phospholipids that are the main components of cell membranes, etc. Exists.

  Calcium phosphate is a main component of the skeleton and an essential element. 100g of soybean contains 704mg, wheat 355mg, brown rice 333mg, cyanobacteria 118mg phosphorus. Selenium contained in 5 μg per 100 g of the present composition protects the living body from active oxygen and radicals by synergistic action with vitamin E and vitamin C.

  Zinc is an essential trace element and the recommended intake is 9 mg per day. It is an essential component for the structure formation and maintenance of enzymes in the body, is involved in its activity, and is greatly involved in assisting the immune system, embryogenesis and growth, and cell division. Each 100g contains 4.89mg of soybean, 2.02mg of brown rice, 2mg of cyanobacteria and 3.3mg of wheat.

  Zinc deficiency has an effect at frequent sites of cell division. Zinc is essential for maintaining the structure of insulin, and is also involved in spermatogenesis, sugar metabolism, and vitamin A activity. If deficiency occurs, these disorders can occur, affecting life support.

  In this way, the substrate material contains many substances that are effective in suppressing cancer and main elements essential for living organisms. According to the present invention, the propagation rate of koji molds in brown rice is increased, and the components are oxidized. Inhibits and keeps the active ingredient intact.

To what extent this composition is actually effective, the following animal experiments were carried out in cooperation with Gifu University, President Hideki Mori and Associate Professor Gifu University, Junya Kuno.
The BOP-induced hamster pancreatic cancer model is an animal carcinogenesis model in which tubular adenocarcinoma similar to human pancreatic cancer occurs.
In order to clarify the effect of this composition raw powder (hereinafter referred to as FBRA) on pancreatic cancer, a preclinical study using this model was performed.

  172 5-week-old female Syrian hamsters were divided into 7 groups, and 10 mg / kg of N-nitrosobis (2-oxopropyl) amine (BOP) was added to induce 1 to 5 groups at 6 weeks of age. It was administered subcutaneously for 4 consecutive days.

  Groups 2 and 3 were administered 1 week before BOP administration until 1 week after completion, and groups 4 and 5 were administered with 5% and 10% FBRA mixed from 1 week after BOP administration until the end of the experiment. .

  Group 6 was fed with 10% FBRA, group 7 was fed with a basic diet throughout the period and served as a negative control. Twenty-two weeks after the start of the experiment, all groups were euthanized, and the pancreas was removed and examined histopathologically.

Research results and discussion
"Weight, liver, kidney weight at the end of the experiment"
Ingestion of 5% and 10% FBRA during the post-initiation period significantly increased body weight and liver weight compared to BOP alone (P <0.01 and 0.01).

“The incidence of pancreatic tumors”
Proliferative lesions occurred in the pancreas of all groups receiving BOP, and no lesions were seen in the non-administered group.
Pancreatic proliferative lesions were morphologically classified into PanIN (pancreatic intraductal neoplasia) 1-3 and invasive tubular adenocarcinoma.

  FIG. 1 is a “histological image of a pancreatic proliferative lesion” (Bar, 50 μm), panIN1 (simple vortex formation) on the upper left, panIN2 (atypical vortex formation) on the upper right, panIN3 (carcinoma in situ) on the lower left, The lower right shows an invasive tubular adenocarcinoma tissue image.

FIG. 2 shows the “number of hamsters with pancreatic duct proliferative lesions” (P <0.05, vs BOP). Ingestion of FBRA ™ tended to decrease the incidence of paninous lesions above PanIN2, while increasing the incidence of PanIN1.
Administration of 10% FBRA diet in the post-initiation period significantly suppressed the occurrence of PanIN2.

  FIG. 3 is a graph showing the “effect of FBRA on the number of tumors in the pancreatic duct per animal”. In each block, BOP, BOP + 5% FBRA, BOP + 10% FBRA, BOP → 5% FBRA, BOP → 10% FBRA are shown from the left.

FBRA intake tended to decrease the average number of PanIN2 intrapancreatic tumors per animal and increase the number of PanIN1 lesions as well as the incidence.
Administration of 5% and 10% FBRA in the post-initiation period significantly suppressed the number of PanIN2 lesions compared to the BOP alone group.

FIG. 4 is a graph showing the “effect of FBRA on the number of pancreatic ductal cancer per animal”. (Upper → invasive tubular adenocarcinoma, lower → PanIN3).
Compared with the BOP alone group, administration of 10% FBRA in the post-initiation period significantly reduced the number of ductal carcinomas.

  As a result of this experiment, FBRA ingestion suppressed the development of BOP-induced hamster pancreatic tumors, and it is considered promising as a candidate for a human pancreatic cancer preventive agent if this composition is continuously ingested at a dose of 20 g or more per day. It came to.

  The pancreas is made up of an acinus that produces pancreatic juice, a pancreatic duct that carries the pancreatic juice, and islets of Langerhans that are endocrine glands. Pancreatic juice is a mixture of digestive enzymes that do not have many types of activity and alkaline secretions secreted from the conduit, and the pH is slightly biased toward the alkali side.

  If this pancreatic juice is neutral or acidic for some reason before going to the duodenum and the pancreatic enzyme is activated, the risk of causing acute pancreatitis or causing cancer due to autolysis is increased.

  Islets of Langerhans are agglomerates of about 200,000 to 2 million spherical cells that produce insulin that lowers blood sugar levels. When this insulin falls, it becomes a hyperglycemic state, a large amount of active oxygen is generated in pancreatic β cells, and there is a risk of diabetes.

  Pancreatic cancer develops in any of the pancreatic buttocks, pancreatic head, pancreatic body, and pancreatic tail. About 90% of pancreatic cancer types are invasive pancreatic duct cancer, pancreatic endocrine tumors that are difficult to treat with anticancer drugs, intraductal papillary mucinous tumors originating from the epithelial duct epithelium, and mucinous cysts that occur frequently in middle-aged women with high malignancy Tumors, rare acinar cell carcinomas, etc.

Pancreatic cancer often progresses at the time of discovery, and it is said that about 70% of cases will recur even after resection, and the 5-year survival rate is only 5%, which is often inoperable. It is.
Therefore, there is an urgent need for a method that can prevent the onset of pancreatic cancer itself.

  The site where cancer occurs is the poor blood flow, resulting in inadequate nutrition, inability to eliminate active oxygen, inability to activate immune cells, and failure in cell regeneration. Risk.

The composition of the present invention is rich in nutrients that inactivate active oxygen, improve capillaries and blood flow, and nutrients that activate immune cells, or abundant functional components that cure and repair inflammation And has a synergistic effect.
It is understood that these synergistic effects have led to the suppression of the onset of pancreatic tumors, and the fact that the onset can be suppressed is a great highlight for the prevention of the onset of pancreatic tumors.

  It is used as a health supplement that suppresses active oxygen and has physiological activity such as promising suppression of tumor development.

FIG. 1 is a “histological image of a proliferative lesion of the pancreas” (Bar, 50 μm). The upper left is panIN1 (simple hyperplasia ), the upper right is panIN2 (atypical hyperplasia ), the lower left is panIN3 (carcinoma in situ), The lower right shows an invasive tubular adenocarcinoma tissue image.

Claims (5)

Milling brown rice into a milled rice ratio of 96% or more with a milling machine to make milled brown rice, a process of adding water to the milled brown rice, a process of separately mixing rice bran and water with a blender to make a hydrolyzed mixture, Mixing the steamed brown rice with water and the water mixture, steaming, then inoculating the seed bacilli and germinating in the culture bed, and by automatically measuring the heat of fermentation, the substrate is stirred to dissipate heat, and the temperature is adjusted to an appropriate temperature. The process of maintaining and after ripening the koji is dried to a moisture content of 4% or less at the product temperature of the substrate of the culture bed to form a powder while maintaining the activity of the enzyme, and if necessary mixed with another composite functional material powder A method for producing a pancreatic tumor onset suppressing composition comprising the steps of: The method for producing a pancreatic tumor onset suppressing composition according to claim 1, wherein the rice mill is a grinding type. 3. The production of a pancreatic tumor onset inhibitory composition according to claim 1 or 2, wherein the milling by the rice milling machine is equal-thickness polished rice in which the grinding degree in the thickness direction is larger than the grinding degree in the length direction. Method. A pancreatic tumor onset suppressing composition produced by the method according to claim 1. A method for producing koji, characterized in that brown rice is refined with a rice mill to a milling ratio of 96% or more to obtain koji-brown rice, which is hydrated and steamed, inoculated with koji mold and fermented on a culture bed.