JP2016020396A5 - - Google Patents

Claims (6)

An anti-E1 ion channel antibody or binding fragment thereof that binds to the E1 extracellular loop of an ion channel, comprising:
The ion channel functions in the regulation of pain, and the antibody or fragment functionally modifies after binding the ion channel to the ion channel ;
The ion channel is a sodium ion channel selected from the group consisting of Na _v 1.3, 1.6, 1.8, and 1.9;
The antibody or the binding fragment thereof, which binds to the E1 loop in domain B or domain C of the ion channel . The anti-E1 ion channel antibody or binding fragment thereof according to claim 1 , wherein the antibody or fragment thereof binds to a Na _v 1.3 peptide having an amino acid sequence selected from the group consisting of SEQ ID NOs: 131 to 134. The anti-E1 ion channel antibody or a binding fragment thereof according to claim 1 , wherein the antibody or a fragment thereof binds to a Na _v 1.6 peptide having an amino acid sequence selected from the group consisting of SEQ ID NOs: 135 to 138. The anti-E1 ion channel antibody or binding fragment thereof according to claim 1 , wherein the antibody or fragment thereof binds to a Na _v 1.8 peptide having an amino acid sequence selected from the group consisting of SEQ ID NOs: 139 to 145. The anti-E1 ion channel antibody or binding fragment thereof according to claim 1 , wherein the antibody or fragment thereof binds to a Na _v 1.9 peptide having an amino acid sequence selected from the group consisting of SEQ ID NOs: 146 to 149. 6. The antibody or fragment according to any one of claims 1 to 5 , wherein the antibody inhibits the function of the relevant ion channel for which it is specific by at least 5 percent in an in vitro patch clamp assay.