JP2016002166A - Biological information display device - Google Patents
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- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 58
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 58
- 230000001133 acceleration Effects 0.000 claims abstract description 39
- 230000003287 optical effect Effects 0.000 claims abstract description 10
- 230000036772 blood pressure Effects 0.000 claims description 7
- 238000005259 measurement Methods 0.000 description 33
- 238000010521 absorption reaction Methods 0.000 description 17
- 210000000707 wrist Anatomy 0.000 description 16
- 229910052760 oxygen Inorganic materials 0.000 description 11
- 239000001301 oxygen Substances 0.000 description 11
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 210000004369 blood Anatomy 0.000 description 10
- 230000036541 health Effects 0.000 description 7
- 230000010365 information processing Effects 0.000 description 7
- 239000000758 substrate Substances 0.000 description 7
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000005192 partition Methods 0.000 description 4
- 230000029058 respiratory gaseous exchange Effects 0.000 description 4
- 230000003321 amplification Effects 0.000 description 3
- 210000001367 artery Anatomy 0.000 description 3
- 230000008033 biological extinction Effects 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 230000004308 accommodation Effects 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000005236 sound signal Effects 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 206010021079 Hypopnoea Diseases 0.000 description 1
- 208000008784 apnea Diseases 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Abstract
Description
本発明は、光学式センサを用いて非侵襲且つ連続的に得られた生体情報を表示する生体情報表示装置に関するものである。 The present invention relates to a biological information display device that displays biological information obtained non-invasively and continuously using an optical sensor.
この種の生体情報表示装置としては、パルスオキシメータが知られている。パルスオキシメータは、赤色光を発する発光素子及び赤外光を発する発光素子を有する発光部と受光素子を有する受光部とを有し、前記発光素子により被験者（使用者）の例えば指又は耳等の生体の一部に光を照射して、前記受光素子により、前記生体の一部を反射及び透過する光の強度を測定して、血液の酸素飽和度を測定するように構成されている。 A pulse oximeter is known as this type of biological information display device. The pulse oximeter has a light emitting part that has a light emitting element that emits red light and a light emitting element that emits infrared light, and a light receiving part that has a light receiving element. By the light emitting element, for example, a finger or an ear of a subject (user) A part of the living body is irradiated with light, the intensity of the light reflected and transmitted through the part of the living body is measured by the light receiving element, and the oxygen saturation of the blood is measured.
そして、このパルスオキシメータは、表示画面上に、脈拍数の数値及び酸素飽和度（ＳｐＯ２）の数値が表示されるように構成されている。なお、パルスオキシメータの中には、脈波波形を表示するものある。 The pulse oximeter is configured such that the pulse rate value and the oxygen saturation (SpO 2 ) value are displayed on the display screen. Some pulse oximeters display a pulse wave waveform.
また、生体情報表示装置には、特許文献１に示すように、パルスオキシメータから得られた酸素飽和度信号の波形と、パルスオキシメータから得られた脈波を示す波形又は脈拍数を示す波形と、呼吸センサから得られた呼吸信号波形と、呼吸センサから得られた音声信号波形とを表示装置に並べて表示するものが考えられている。この生体情報表示装置は、酸素飽和度信号の波形と呼吸信号の波形及び音声信号の波形とを同様な時間変化で並べて表示することで、例えば無呼吸・低呼吸の状態を、容易に且つ確実に判定することができるように構成されている。 In addition, as shown in Patent Document 1, the biological information display device includes a waveform of an oxygen saturation signal obtained from a pulse oximeter and a waveform indicating a pulse wave or a pulse rate obtained from the pulse oximeter. It is also considered that the respiration signal waveform obtained from the respiration sensor and the sound signal waveform obtained from the respiration sensor are displayed side by side on a display device. This biological information display device displays the waveform of the oxygen saturation signal, the waveform of the respiration signal, and the waveform of the audio signal side by side with the same time change, so that, for example, an apnea / hypopnea state can be easily and reliably performed. It is configured so that it can be determined.
ところで、本願発明者は、酸素飽和度（ＳｐＯ２）とその他の生体情報を関連付けて表示するのではなく、ヘモグロビン濃度に着目し、当該ヘモグロビン濃度と、脈波及び加速度脈波とを関連付けて表示することによって、ヘモグロビン濃度と、脈波及び加速度脈波との関係から、健康管理を行うことを考えている。 By the way, the present inventor does not display the oxygen saturation (SpO 2 ) and other biological information in association with each other, but focuses on the hemoglobin concentration and displays the hemoglobin concentration in association with the pulse wave and the acceleration pulse wave. By doing so, it is considered to perform health management from the relationship between the hemoglobin concentration, the pulse wave and the acceleration pulse wave.
そこで本発明は、ヘモグロビン濃度と脈波及び加速度脈波とを関連付けて表示することによって、ヘモグロビン濃度と脈波及び加速度脈波との関係から、適切な健康管理を行うことができる生体情報表示装置を提供することをその主たる課題とするものである。 Therefore, the present invention provides a biological information display device that can perform appropriate health management from the relationship between the hemoglobin concentration, the pulse wave, and the acceleration pulse wave by displaying the hemoglobin concentration, the pulse wave, and the acceleration pulse wave in association with each other. The main issue is to provide the service.
すなわち本発明に係る生体情報表示装置は、光学式センサにより得られた光強度信号を用いて、少なくとも脈波情報、ヘモグロビン濃度情報及び加速度脈波情報を含む生体情報を生成する生体情報生成部と、前記生体情報生成部から前記生体情報を受け付けて、少なくとも脈波波形、ヘモグロビン濃度波形及び加速度脈波波形を同一画面上に同時に同期させて表示させる表示制御部とを備えることを特徴とする。 That is, the biological information display apparatus according to the present invention includes a biological information generation unit that generates biological information including at least pulse wave information, hemoglobin concentration information, and acceleration pulse wave information using a light intensity signal obtained by an optical sensor. And a display control unit that receives the biological information from the biological information generation unit and displays at least a pulse wave waveform, a hemoglobin concentration waveform, and an acceleration pulse wave waveform simultaneously in synchronization on the same screen.
このようなものであれば、少なくとも脈波波形、ヘモグロビン濃度波形及び加速度脈波波形を同一画面上に同期させて表示しているので、ヘモグロビン濃度と脈波及び加速度脈波との相互の関係から、適切な健康管理を行うことができる。
ここで、従来のように基本的に各種測定結果を数値で表示するものでは、各種測定結果の関連性が分かり難く、被験者（使用者）の疾患又はその疾患の原因を把握又は予測し難い。一方で、本発明は、少なくとも脈波、ヘモグロビン濃度及び加速度脈波をそれぞれ波形で表示しているので、脈波、ヘモグロビン濃度及び加速度の変化態様を見比べることで、被験者（使用者）の疾患又はその疾患の原因を把握又は予測いし易くすることができる。
具体的には、不整脈を診断する場合には、脈波（脈拍）だけでは把握が難しいが、当該脈拍とともに、加速度脈波を用いることで把握することができる。
また、生理的変動に伴って変化する、ヘモグロビン濃度、脈波及び加速度脈波の関係から、被験者の健康診断を行うことができる。例えば、ヘモグロビン濃度が高い場合には、脱水症状等の疾患が疑われ、このときの脈波及び加速度脈波を見ることで、脱水症状等であるか否かをより確実に判断することができる。また、ヘモグロビン濃度が低い場合には、真正多血省や貧血等の疾患が疑われ、このときの脈波及び加速度脈波を見ることで、貧血等であるか否かをより確実に判断することができる。
その他、前記生体情報が、血中酸素濃度（ＳｐＯ２）情報をさらに含み、前記表示制御部が、前記脈波波形、前記ヘモグロビン濃度波形及び前記加速度脈波波形とともに、ＳｐＯ２波形を表示するものであれば、組織の生死判定を行うこともできる。
If this is the case, since at least the pulse waveform, hemoglobin concentration waveform, and acceleration pulse waveform are displayed in synchronization on the same screen, the relationship between the hemoglobin concentration, the pulse wave, and the acceleration pulse wave Appropriate health management can be performed.
Here, when various measurement results are displayed numerically as in the prior art, it is difficult to understand the relevance of various measurement results, and it is difficult to grasp or predict the disease of the subject (user) or the cause of the disease. On the other hand, since the present invention displays at least the pulse wave, hemoglobin concentration, and acceleration pulse wave as waveforms, respectively, by comparing changes in the pulse wave, hemoglobin concentration, and acceleration, The cause of the disease can be easily grasped or predicted.
Specifically, when arrhythmia is diagnosed, it is difficult to grasp only by a pulse wave (pulse), but it can be grasped by using an acceleration pulse wave together with the pulse.
In addition, the health examination of the subject can be performed from the relationship between the hemoglobin concentration, the pulse wave, and the acceleration pulse wave that change with physiological fluctuations. For example, when the hemoglobin concentration is high, a disease such as dehydration is suspected, and it can be more reliably determined whether or not it is dehydration by looking at the pulse wave and acceleration pulse wave at this time . In addition, when the hemoglobin concentration is low, diseases such as the Ministry of Authenticity and anemia are suspected, and it is determined more reliably whether or not it is anemia by observing the pulse wave and acceleration pulse wave at this time. be able to.
In addition, the biological information further includes blood oxygen concentration (SpO 2 ) information, and the display control unit displays the SpO 2 waveform together with the pulse waveform, the hemoglobin concentration waveform, and the acceleration pulse waveform. If so, it is possible to determine whether the tissue is alive or dead.
生体情報表示装置の使い勝手をより良くするためには、前記生体情報が、推定血圧をさらに含み、前記表示制御部が、前記脈波波形、前記ヘモグロビン濃度波形及び前記加速度脈波波形とともに、前記推定血圧を表示するものであることが望ましい。 In order to improve the usability of the biological information display device, the biological information further includes estimated blood pressure, and the display control unit performs the estimation together with the pulse wave waveform, the hemoglobin concentration waveform, and the acceleration pulse wave waveform. It is desirable to display blood pressure.
前記表示制御部が、前記脈波波形を示すグラフ、前記ヘモグロビン濃度波形を示すグラフ及び前記加速度脈波波形を示すグラフを上下方向又は左右方向の所定方向に一覧表示し、当該一覧表示した各グラフの時間軸の表示範囲が同じであることが望ましい。
これならば、脳波波形、ヘモグロビン濃度波形及び加速度脈波波形の時間的な対応関係を一見して認識することができ、生体情報表示装置の使い勝手をより一層向上させることができる。
The display control unit displays a graph showing the pulse wave waveform, a graph showing the hemoglobin concentration waveform, and a graph showing the acceleration pulse wave waveform in a predetermined direction in the vertical direction or the horizontal direction, and each graph displayed in the list It is desirable that the display range of the time axis is the same.
If this is the case, it is possible to recognize at a glance the temporal correspondence of the electroencephalogram waveform, the hemoglobin concentration waveform, and the acceleration pulse wave waveform, and the usability of the biological information display device can be further improved.
このような構成の本発明によれば、少なくとも脈波波形、ヘモグロビン濃度波形及び加速度脈波波形を同一画面上に同時に同期させて表示するので、ヘモグロビン濃度と脈波及び加速度脈波との相互の関係から、適切な健康管理を行うことができる。 According to the present invention having such a configuration, at least the pulse wave waveform, the hemoglobin concentration waveform, and the acceleration pulse wave waveform are displayed on the same screen in synchronization with each other. From the relationship, appropriate health management can be performed.
以下に本発明の生体情報表示装置を用いた生体情報計測システムの一実施形態について図面を参照して説明する。 Hereinafter, an embodiment of a biological information measurement system using the biological information display device of the present invention will be described with reference to the drawings.
本実施形態の生体情報計測システム１００は、被験者（使用者）の生体情報を非侵襲且つ連続的に計測するものであり、使用者の手首の血管を流れる血液から少なくとも脈拍及び血中酸素濃度を取得する手首装着型パルスオキシメータである。 The biological information measuring system 100 of the present embodiment measures non-invasively and continuously the biological information of a subject (user), and at least the pulse and blood oxygen concentration are obtained from the blood flowing through the blood vessel of the user's wrist. This is a wrist-worn pulse oximeter to be acquired.
具体的にこの生体情報計測システム１００は、図１に示すように、使用者の手首に装着される計測ユニット２と、当該計測ユニット２により得られたデータを演算処理して生体情報を生成する情報処理ユニット３とを備えている。 Specifically, as shown in FIG. 1, the biological information measurement system 100 generates biological information by performing arithmetic processing on a measurement unit 2 worn on a user's wrist and data obtained by the measurement unit 2. And an information processing unit 3.
まず、計測ユニット２について詳述する。
計測ユニット２は、手首の動脈を通る血液に検査光を照射するとともに、当該血液により反射して手首の生体組織を透過して外部に出た反射光を検出するものである。
First, the measurement unit 2 will be described in detail.
The measurement unit 2 irradiates the blood passing through the artery of the wrist with inspection light, and detects reflected light that is reflected by the blood, passes through the biological tissue of the wrist, and exits to the outside.
具体的に計測ユニット２は、図１及び図２に示すように、手首に巻回されて装着される巻回タイプのものであり、前記検査光を手首に照射するとともに前記反射光を検出する光学センサ部２１と、当該光学センサ部２１が取り付けられ、手首に巻回される装着ベルト２２とを備えている。なお、装着ベルト２２は、手首に装着できる構成であれば良く、例えば面ファスナーやバックル等を有するものが考えられる。 Specifically, as shown in FIGS. 1 and 2, the measurement unit 2 is of a wound type that is wound around a wrist, and irradiates the wrist with the inspection light and detects the reflected light. An optical sensor unit 21 and a mounting belt 22 to which the optical sensor unit 21 is attached and wound around the wrist are provided. The mounting belt 22 may be configured to be mounted on the wrist. For example, a belt having a hook-and-loop fastener, a buckle, or the like is conceivable.
光学センサ部２１は、特に図２に示すように、互いに波長の異なる赤外光を検査光として手首に照射する発光部２１１と、手首の生体組織を透過して外部に出た赤外光を受光する受光素子２１２ａを有する受光部２１２と、発光部２１１及び受光部２１２を支持する計測基板２１３とを備えている。 As shown in FIG. 2 in particular, the optical sensor unit 21 emits infrared light that irradiates the wrist with infrared light having different wavelengths as inspection light and infrared light that has passed through the living tissue of the wrist and exited to the outside. A light receiving unit 212 having a light receiving element 212 a that receives light, and a light emitting unit 211 and a measurement substrate 213 that supports the light receiving unit 212 are provided.
発光部２１１は、第１波長の赤外光を射出する第１発光素子２１１ａ及び第１波長よりも波長の長い第２波長の赤外光を射出する第２発光素子２１１ｂを有する。 The light emitting unit 211 includes a first light emitting element 211a that emits infrared light having a first wavelength and a second light emitting element 211b that emits infrared light having a second wavelength that is longer than the first wavelength.
第１発光素子２１１ａ及び第２発光素子２１１ｂはともにＬＥＤから構成されており、例えば表面実装型ＬＥＤであり、集光レンズが一体に形成されたレンズ付きのものであっても良い。 Both the first light-emitting element 211a and the second light-emitting element 211b are constituted by LEDs, for example, surface-mounted LEDs, and may be provided with a lens in which a condenser lens is integrally formed.
そして、本実施形態の第１発光素子２１１ａの第１波長及び第２発光素子２１１ｂの第２波長は、次のように設定されている。
つまり、図３に示すように、第１波長における脱酸素化ヘモグロビン及び酸素化ヘモグロビンの吸収係数（脱酸素化ヘモグロビンの吸収係数（モル分子吸光係数）と酸素化ヘモグロビンの吸収係数（モル分子吸光係数）との和）と、第２波長における脱酸素化ヘモグロビン及び酸素化ヘモグロビンの吸収係数とが実質的に同一となるように設定されている。より具体的には、第１波長は、脱酸素化ヘモグロビンの吸収係数と酸素化ヘモグロビンの吸収係数が同一となる等吸収点の波長（約８０５ｎｍ）よりも短い波長であり、第２波長は、前記等吸収点の波長（約８０５ｎｍ）よりも長い波長である。具体的に本実施形態では、第１波長は７６０ｎｍであり、第２波長は８５０ｎｍである。
And the 1st wavelength of the 1st light emitting element 211a of this embodiment and the 2nd wavelength of the 2nd light emitting element 211b are set as follows.
That is, as shown in FIG. 3, the absorption coefficient of deoxygenated hemoglobin and oxygenated hemoglobin at the first wavelength (the absorption coefficient of deoxygenated hemoglobin (molar molecular extinction coefficient) and the absorption coefficient of oxygenated hemoglobin (molar molecular extinction coefficient). )) And the absorption coefficient of deoxygenated hemoglobin and oxygenated hemoglobin at the second wavelength are set to be substantially the same. More specifically, the first wavelength is a wavelength shorter than the wavelength of the isosbestic point (about 805 nm) at which the absorption coefficient of deoxygenated hemoglobin and the absorption coefficient of oxygenated hemoglobin are the same, and the second wavelength is The wavelength is longer than the wavelength of the isosbestic point (about 805 nm). Specifically, in the present embodiment, the first wavelength is 760 nm and the second wavelength is 850 nm.
このように、第１波長における脱酸素化ヘモグロビン及び酸素化ヘモグロビンの吸収係数と第２波長における脱酸素化ヘモグロビン及び酸素化ヘモグロビンの吸収係数とが実質的に同一となるように、第１波長及び第２波長が設定されているので、後述する情報処理ユニット３における信号処理、具体的には、信号処理回路３２における増幅率を、第１波長及び第２波長の区別無く同一にすることができ、信号処理を簡易にすることができる。
また、単一の増幅回路により同一の増幅率で信号を増幅することにより、第１波長の信号（電圧信号）と第２波長の信号（電圧信号）とで、増幅により生じるノイズを同じにすることができる。これにより、後述するヘモグロビン濃度等の測定精度を向上させることができる。
さらに、手首装着型の計測ユニット２において、従来のように６４０ｎｍ（赤色光）及び９４０ｎｍ（赤外光）を用いたものでは、動脈まで光が届きにくくＳ／Ｎ比が悪くなってしまうが、本実施形態では第１波長及び第２波長を赤外波長領域から選択しているので、動脈まで光を届かせることができ、Ｓ／Ｎ比を良くすることができる。つまり、各発光素子２１１ａ、２１１ｂの波長を赤外波長領域から選択することで、手首装着型の計測ユニット２に好適に用いることができる。
Thus, the first wavelength and the absorption coefficient of deoxygenated hemoglobin and oxygenated hemoglobin at the first wavelength and the absorption coefficient of deoxygenated hemoglobin and oxygenated hemoglobin at the second wavelength are substantially the same. Since the second wavelength is set, the signal processing in the information processing unit 3 to be described later, specifically, the amplification factor in the signal processing circuit 32 can be made the same without distinction between the first wavelength and the second wavelength. , Signal processing can be simplified.
Further, by amplifying the signal with the same amplification factor by a single amplifier circuit, the noise generated by the amplification is made the same for the first wavelength signal (voltage signal) and the second wavelength signal (voltage signal). be able to. Thereby, measurement accuracy, such as a hemoglobin density | concentration mentioned later, can be improved.
Furthermore, in the wrist-worn type measurement unit 2, when using 640 nm (red light) and 940 nm (infrared light) as in the prior art, it is difficult for light to reach the artery, and the S / N ratio deteriorates. In the present embodiment, since the first wavelength and the second wavelength are selected from the infrared wavelength region, the light can reach the artery and the S / N ratio can be improved. That is, by selecting the wavelength of each light emitting element 211a, 211b from the infrared wavelength region, it can be suitably used for the wrist-worn type measurement unit 2.
受光部２１２は、第１波長の赤外光及び第２波長の赤外光に対して検出感度を有する受光素子２１２ａを有しており、本実施形態では、第１波長（７６０ｎｍ）及び第２波長（８５０ｎｍ）を含む感度波長範囲を有するセラミックパッケージフォトダイオードである。セラミックパッケージフォトダイオードを用いることで、パッケージの側面等からの迷光入射が防ぎ、高精度に赤外光を測定することができる。
なお、受光部２１２は、第１波長の赤外光を検出する第１受光素子及び第２波長の赤外光を検出する第２受光素子を有するものであっても良い。
The light receiving unit 212 includes a light receiving element 212a having detection sensitivity with respect to infrared light having a first wavelength and infrared light having a second wavelength. In the present embodiment, the light receiving unit 212a has a first wavelength (760 nm) and a second wavelength. It is a ceramic package photodiode having a sensitivity wavelength range including a wavelength (850 nm). By using a ceramic package photodiode, it is possible to prevent stray light from entering from the side surface of the package and to measure infrared light with high accuracy.
The light receiving unit 212 may include a first light receiving element that detects infrared light having a first wavelength and a second light receiving element that detects infrared light having a second wavelength.
計測基板２１３は、前記第１発光素子２１１ａ、第２発光素子２１１ｂ及び受光素子２１２ａが固定されるとともに発光素子２１１ａ、２１１ｂに給電するための配線及び受光素子２１２ａにより生じた逆電流を検出するための配線が施されている。また、本実施形態の計測基板２１３には、受光素子２１２ａにより生じた逆電流を電圧に変換するための電流−電圧変換回路２１４（図４参照）が搭載されている。なお、本実施形態の計測基板２１３は、平板状をなすものである。なお、第１発光素子２１１ａ及び第２発光素子２１１ｂへの給電の制御及び受光素子２１２ａにより得られた電圧信号の演算処理は、後述する情報処理ユニット３により行われる。 The measurement substrate 213 detects the reverse current generated by the light receiving element 212a and the wiring for supplying power to the light emitting elements 211a and 211b while the first light emitting element 211a, the second light emitting element 211b, and the light receiving element 212a are fixed. Wiring is applied. In addition, a current-voltage conversion circuit 214 (see FIG. 4) for converting a reverse current generated by the light receiving element 212a into a voltage is mounted on the measurement substrate 213 of the present embodiment. In addition, the measurement board | substrate 213 of this embodiment makes flat form. Note that the power supply control to the first light emitting element 211a and the second light emitting element 211b and the calculation process of the voltage signal obtained by the light receiving element 212a are performed by the information processing unit 3 described later.
この光学センサ部２１において、図２に示すように、第１発光素子２１１ａ及び第２発光素子２１１ｂと受光素子２１２ａとの高さ位置が、所定の基準面に対して互いに異なるように構成されている。 In this optical sensor unit 21, as shown in FIG. 2, the height positions of the first light emitting element 211a, the second light emitting element 211b, and the light receiving element 212a are configured to be different from each other with respect to a predetermined reference plane. Yes.
具体的には、受光素子２１２ａの受光面（不図示）の高さ位置が、計測基板２１３の取り付け面２１３ｘに対して、第１発光素子２１１ａ及び第２発光素子２１１ｂの発光面（不図示）の高さ位置よりも高くなるように固定されている。つまり、受光素子２１２ａの受光面が、計測基板２１３の取り付け面２１３ｘに対して、第１発光素子２１１ａ及び第２発光素子２１１ｂの発光面よりも前方に位置している。これにより、計測ユニット２を手首に装着した状態において、受光素子２１２ａが手首側に位置することになる。これにより、第１発光素子２１１ａ及び第２発光素子２１１ｂからの直接光が受光素子２１２ａに直接受光されることを一層防ぐことができる。 Specifically, the height position of the light receiving surface (not shown) of the light receiving element 212a is the light emitting surface (not shown) of the first light emitting element 211a and the second light emitting element 211b with respect to the mounting surface 213x of the measurement substrate 213. It is fixed so as to be higher than the height position. That is, the light receiving surface of the light receiving element 212a is located in front of the light emitting surfaces of the first light emitting element 211a and the second light emitting element 211b with respect to the mounting surface 213x of the measurement substrate 213. Accordingly, the light receiving element 212a is positioned on the wrist side in a state where the measurement unit 2 is attached to the wrist. This can further prevent direct light from the first light emitting element 211a and the second light emitting element 211b from being directly received by the light receiving element 212a.
また、本実施形態の計測ユニット２は、計測基板２１３と手首との間に設けられ、光学センサ部２１の手首に対する接触圧を調整するクッション部材２３を備えている。 In addition, the measurement unit 2 of the present embodiment includes a cushion member 23 that is provided between the measurement board 213 and the wrist and adjusts the contact pressure of the optical sensor unit 21 to the wrist.
クッション部材２３は、光学センサ部２１が手首に与える接触圧を分散及び均一化するものであり、スポンジ状をなすゴムから形成されており、発光部２１１を構成する第１発光素子２１１ａ及び第２発光素子２１１ｂと、受光部２１２を構成する受光素子２１２ａの周囲を取り囲むように構成されている。具体的にクッション部材２３は、計測基板２１３の取り付け面２１３ｘに固定されており、第１発光素子２１１ａが内部に配置される第１収容孔部２３１と、第２発光素子２１１ｂが内部に配置される第２収容孔部２３２と、受光素子２１２ａが内部に配置される受光用収容孔部２３３とが形成されている。 The cushion member 23 disperses and equalizes the contact pressure applied to the wrist by the optical sensor unit 21. The cushion member 23 is formed of sponge-like rubber, and includes a first light emitting element 211 a and a second light emitting unit 211. The light emitting element 211b and the light receiving element 212a constituting the light receiving unit 212 are surrounded. Specifically, the cushion member 23 is fixed to the attachment surface 213x of the measurement substrate 213, and the first housing hole 231 in which the first light emitting element 211a is disposed and the second light emitting element 211b are disposed in the interior. A second receiving hole 232 and a light receiving hole 233 in which the light receiving element 212a is disposed.
このように構成したクッション部材２３において、第１収容孔部２３１と受光用収容孔部２３３との間の部分２３４が第１発光素子２１１ａと受光素子２１２ａとの間を仕切る仕切壁部となり、第２収容孔部２３２と受光用収容孔部２３３との間の部分２３５が第２発光素子２１１ｂと受光素子２１２ａとの間を仕切る仕切壁部となる。これにより、第１発光素子２１１ａ及び第２発光素子２１１ｂからの直接光が受光素子２１２ａに直接受光されることを一層防ぐことができる。 In the cushion member 23 configured as described above, a portion 234 between the first accommodation hole 231 and the light receiving accommodation hole 233 serves as a partition wall that partitions the first light emitting element 211a and the light receiving element 212a. A portion 235 between the two housing holes 232 and the light receiving housing 233 serves as a partition wall that partitions the second light emitting element 211b and the light receiving element 212a. This can further prevent direct light from the first light emitting element 211a and the second light emitting element 211b from being directly received by the light receiving element 212a.
次に、情報処理ユニット３について詳述する。
情報処理ユニット３は、計測ユニット２の発光部２１１を制御するとともに、受光部２１２により得られた電圧信号を処理して、生体情報を生成するものである。
Next, the information processing unit 3 will be described in detail.
The information processing unit 3 controls the light emitting unit 211 of the measurement unit 2 and processes the voltage signal obtained by the light receiving unit 212 to generate biological information.
具体的に情報処理ユニット３は、図４に示すように、第１発光素子２１１ａ及び第２発光素子２１１ｂを交互点灯させるためのＬＥＤ制御回路部３１と、電流−電圧変換回路２１４から出力される電圧信号を増幅して波長毎の電圧信号に分離する信号処理回路部３２と、信号処理回路部３２により得られた各波長の電圧信号から生体情報を生成する演算処理部３３とを有している。なお、本実施形態では、ＬＥＤ制御回路部３１及び信号処理回路部３２は、単一のメイン基板３００上に搭載されている。 Specifically, as shown in FIG. 4, the information processing unit 3 outputs the LED control circuit unit 31 for alternately lighting the first light emitting element 211 a and the second light emitting element 211 b and the current-voltage conversion circuit 214. A signal processing circuit unit 32 that amplifies the voltage signal and separates it into voltage signals for each wavelength, and an arithmetic processing unit 33 that generates biological information from the voltage signals of each wavelength obtained by the signal processing circuit unit 32. Yes. In the present embodiment, the LED control circuit unit 31 and the signal processing circuit unit 32 are mounted on a single main board 300.
ＬＥＤ制御回路部３１は、所定の周期で第１発光素子２１１ａ及び第２発光素子２１１ｂを交互点灯させるものであり、例えば、タイマーＩＣとシュミットトリガーとを用いて構成されている。なお、ＬＥＤ制御回路部３１は、計測基板２１３（発光部２１１）と電気ケーブルにより接続されている。 The LED control circuit unit 31 alternately turns on the first light emitting element 211a and the second light emitting element 211b at a predetermined cycle, and is configured using, for example, a timer IC and a Schmitt trigger. The LED control circuit unit 31 is connected to the measurement board 213 (light emitting unit 211) by an electric cable.
信号処理回路部３２は、電流−電圧変換回路２１４から出力される電圧信号（アナログ信号）を増幅するオペアンプを用いた増幅回路と、増幅された電圧信号を各発光素子の発光タイミングに同期させて、第１発光素子２１１ａが発光した際に得られた電圧信号と第２発光素子２１１ｂが発光した際に得られた電圧信号とに分離するものである。なお、信号処理回路部３２は、計測基板２１３（電流−電圧変換回路２１４）と電気ケーブルにより接続されているとともに、演算処理部３３と電気ケーブルにより接続されている。 The signal processing circuit unit 32 is configured to amplify a voltage signal (analog signal) output from the current-voltage conversion circuit 214 using an operational amplifier, and synchronize the amplified voltage signal with the light emission timing of each light emitting element. The voltage signal obtained when the first light emitting element 211a emits light and the voltage signal obtained when the second light emitting element 211b emits light are separated. The signal processing circuit unit 32 is connected to the measurement board 213 (current-voltage conversion circuit 214) by an electric cable, and is also connected to the arithmetic processing unit 33 by an electric cable.
演算処理部３３は、信号処理回路部３２により得られた各波長の電圧信号を取得してデジタル信号に変換するとともに、当該デジタル信号を演算処理することにより、生体情報を生成する。なお、演算処理部３３は、ＣＰＵ、メモリ、ＡＤ変換器、入出力インターフェイス、キーボードやマウス等の入力手段及びディスプレイを有する専用乃至汎用のコンピュータである。なお、入力手段及びディスプレイが一体とされたタッチパネルディスプレイであっても良い。 The arithmetic processing unit 33 acquires the voltage signal of each wavelength obtained by the signal processing circuit unit 32 and converts it into a digital signal, and generates biological information by performing arithmetic processing on the digital signal. The arithmetic processing unit 33 is a dedicated or general-purpose computer having a CPU, a memory, an AD converter, an input / output interface, an input unit such as a keyboard and a mouse, and a display. A touch panel display in which the input unit and the display are integrated may be used.
そして、この演算処理部３３は、前記メモリに格納された各種プログラムをＣＰＵによって実行することにより、図５に示すように、信号受付部３３ａ、生体情報生成部３３ｂ、表示制御部３３ｃ、ユーザ入力受付部３３ｄ等の機能を発揮するものである。 Then, the arithmetic processing unit 33 executes various programs stored in the memory by the CPU, so that a signal receiving unit 33a, a biological information generating unit 33b, a display control unit 33c, a user input, as shown in FIG. The function of the receiving unit 33d and the like is exhibited.
信号受付部３３ａは、信号処理回路部３２により得られた各波長の電圧信号を取得してデジタル信号に変換して、光強度信号を生成するものである。 The signal receiving unit 33a acquires the voltage signal of each wavelength obtained by the signal processing circuit unit 32, converts it into a digital signal, and generates a light intensity signal.
生体情報生成部３３ｂは、信号受付部３３ａにより得られた光強度信号を取得して、当該光強度信号を用いて各種生体情報を生成するものである。 The biological information generation unit 33b acquires the light intensity signal obtained by the signal reception unit 33a, and generates various biological information using the light intensity signal.
具体的に生体情報生成部３３ｂは、第１波長の光強度信号又は第２波長の光強度信号を用いて脈波情報又は脈拍情報を生成し、前記脈波情報を２回微分することにより、加速度脈波情報を生成する。
また、生体情報生成部３３ｂは、第１波長の光強度信号から、第１波長の赤外光を照射した場合の第１吸収係数を算出するとともに、第２波長の光強度信号から、第２波長の赤外光を照射した場合の第２吸収係数を算出して、これら第１吸収係数及び第２吸収係数を用いて、血液中のヘモグロビン濃度（脱酸素化ヘモグロビン濃度及び酸素化ヘモグロビン濃度の和）を算出して、ヘモグロビン濃度情報を生成する。
さらに、生体情報生成部３３ｂは、第１吸収係数及び第２吸収係数を用いて血中酸素濃度（ＳｐＯ２）を算出し、血中酸素濃度情報を生成する。
Specifically, the biological information generation unit 33b generates pulse wave information or pulse information using the light intensity signal of the first wavelength or the light intensity signal of the second wavelength, and differentiates the pulse wave information twice, Acceleration pulse wave information is generated.
In addition, the biological information generation unit 33b calculates a first absorption coefficient when irradiating infrared light of the first wavelength from the light intensity signal of the first wavelength, and calculates the second absorption coefficient from the light intensity signal of the second wavelength. The second absorption coefficient when irradiated with infrared light of a wavelength is calculated, and the hemoglobin concentration in blood (deoxygenated hemoglobin concentration and oxygenated hemoglobin concentration is calculated using the first absorption coefficient and the second absorption coefficient. Sum) is calculated to generate hemoglobin concentration information.
Furthermore, the biological information generation unit 33b calculates blood oxygen concentration (SpO 2 ) using the first absorption coefficient and the second absorption coefficient, and generates blood oxygen concentration information.
表示制御部３３ｃは、前記生体情報生成部３３ｂにより得られた各種生体情報をディスプレイ上に表示するものである。 The display control unit 33c displays various biological information obtained by the biological information generation unit 33b on a display.
具体的に表示制御部３３ｃは、図６に示すように、ディスプレイの画面上に、機器制御設定領域Ｗ１、計算用パラメータ設定領域Ｗ２、グラフ用パラメータ設定領域Ｗ３、ピーク計算領域Ｗ４及びグラフ表示領域Ｗ５を表示するものである。 Specifically, as shown in FIG. 6, the display control unit 33c has a device control setting area W1, a calculation parameter setting area W2, a graph parameter setting area W3, a peak calculation area W4, and a graph display area on the display screen. W5 is displayed.
本実施形態では、機器制御設定領域Ｗ１、計算用パラメータ設定領域Ｗ２、グラフ用パラメータ設定領域Ｗ３及びピーク計算領域Ｗ４を画面の左領域に上下方向に一覧表示し、画面の右側にグラフ表示領域Ｗ５を表示した場合を示しているが、各領域Ｗ１〜Ｗ５の配置態様は、これに限られない。 In the present embodiment, the device control setting area W1, the calculation parameter setting area W2, the graph parameter setting area W3, and the peak calculation area W4 are listed in the vertical direction in the left area of the screen, and the graph display area W5 is displayed on the right side of the screen. However, the arrangement of the areas W1 to W5 is not limited to this.
機器制御設定領域Ｗ１は、点灯させる発光素子（ＣＮ１〜ＣＮ４のチェックボックス）の選択、及び選択した発光素子の光量調整（Ｒａｎｇｅ（±５Ｖ））の設定、交互点灯の周期（Ｃｌｏｃｋ Ｉｎｔｅｒｖａｌ＝１０００）の設定、及び、測定開始（Ｓｔａｒｔボタン）、測定終了（Ｓｔｏｐボタン）、及び、測定データ記録（Ｓａｖｅボタン）を行うためのものである。なお、これらの設定は、使用者が入力手段を用いて行い、当該入力手段による入力信号は、ユーザ入力受付部３３ｄにより受け付けられる。 The device control setting area W1 selects a light emitting element to be turned on (check boxes of CN1 to CN4), sets a light amount adjustment (Range (± 5 V)) of the selected light emitting element, and alternately turns on (Clock Interval = 1000). , Measurement start (Start button), measurement end (Stop button), and measurement data recording (Save button). These settings are made by the user using the input means, and an input signal from the input means is received by the user input receiving unit 33d.
計算用パラメータ設定領域Ｗ２は、酸素化ヘモグロビン濃度、脱酸素化ヘモグロビン濃度及び全ヘモグロビン濃度を計算するためのパラメータの設定、血中酸素濃度（ＳｐＯ２）を計算するためのパラメータの設定、加速度脈波を計算するためのパラメータの設定などを行うためのものである。なお、これらの設定は、使用者が入力手段を用いて行い、当該入力手段による入力信号は、ユーザ入力受付部３３ｄにより受け付けられる。 The parameter setting area for calculation W2 includes setting of parameters for calculating oxygenated hemoglobin concentration, deoxygenated hemoglobin concentration and total hemoglobin concentration, setting of parameters for calculating blood oxygen concentration (SpO 2 ), acceleration pulse This is for setting parameters for calculating waves. These settings are made by the user using the input means, and an input signal from the input means is received by the user input receiving unit 33d.
グラフ用パラメータ設定領域Ｗ３は、グラフの描画間隔及び表示範囲の設定、各グラフの縦軸の最大値及び最小値の設定を行うためのものである。また、ピーク計算領域Ｗ４は、脈、酸素度、脈間隔、吸収率などのピーク値を表示する領域である。なお、これらの設定は、使用者が入力手段を用いて行い、当該入力手段による入力信号は、ユーザ入力受付部３３ｄにより受け付けられる。 The graph parameter setting area W3 is used for setting the drawing interval and display range of the graph, and setting the maximum value and the minimum value of the vertical axis of each graph. The peak calculation area W4 is an area for displaying peak values such as a pulse, an oxygen level, a pulse interval, and an absorption rate. These settings are made by the user using the input means, and an input signal from the input means is received by the user input receiving unit 33d.
そして、グラフ表示領域Ｗ５には、脈波波形、ヘモグロビン濃度波形、加速度脈波波形及びＳｐＯ２波形が表示される。具体的には、グラフ表示領域Ｗ５において、上下方向に沿って、脈波波形を示すグラフＧ１、ヘモグロビン濃度波形を示すグラフＧ２、加速度脈波波形を示すグラフＧ３及びＳｐＯ２波形を示すグラフＧ４が一覧表示される。本実施形態では、上から順に、ヘモグロビン濃度波形を示すグラフＧ２、ＳｐＯ２波形を示すグラフＧ４、脈波波形を示すグラフＧ１、及び、加速度脈波波形を示すグラフＧ３が並べて表示されている。 In the graph display area W5, a pulse waveform, a hemoglobin concentration waveform, an acceleration pulse waveform, and an SpO 2 waveform are displayed. Specifically, in the graph display area W5, a graph G1 indicating a pulse waveform, a graph G2 indicating a hemoglobin concentration waveform, a graph G3 indicating an acceleration pulse waveform, and a graph G4 indicating an SpO 2 waveform along the vertical direction. Listed. In the present embodiment, a graph G2 showing a hemoglobin concentration waveform, a graph G4 showing an SpO 2 waveform, a graph G1 showing a pulse waveform, and a graph G3 showing an acceleration pulse waveform are displayed in order from the top.
そして、各グラフＧ１〜Ｇ４の時間軸は、横軸に設定されており、各グラフＧ１〜Ｇ４の時間軸の表示範囲が同じになるように表示されている。なお、この横軸の表示範囲及び時間間隔は、グラフ用パラメータ設定領域Ｗ３の表示範囲の入力欄及び描画間隔の入力欄に任意の数値を入力することによって変更可能である。本実施形態では、グラフ用パラメータ設定領域Ｗ３の表示範囲及び描画間隔によりそれらを設定することによって、全てのグラフＧ１〜Ｇ４の時間軸を一括して変更可能に構成している。また、各グラフＧ１〜Ｇ４の縦軸の最大値及び最小値もグラフ用パラメータ設定領域Ｗ３の各グラフＧ１〜Ｇ４に対応する入力欄に任意の数値を入力することによってグラフＧ１〜Ｇ４毎に変更可能である。 And the time axis of each graph G1-G4 is set to the horizontal axis, and it displays so that the display range of the time axis of each graph G1-G4 may become the same. The display range and time interval on the horizontal axis can be changed by inputting arbitrary numerical values in the display range input field and the drawing interval input field of the graph parameter setting area W3. In the present embodiment, the time axis of all the graphs G1 to G4 can be collectively changed by setting them according to the display range and drawing interval of the graph parameter setting area W3. Further, the maximum value and the minimum value on the vertical axis of each graph G1 to G4 are also changed for each graph G1 to G4 by inputting arbitrary numerical values in the input fields corresponding to the graphs G1 to G4 in the graph parameter setting area W3. Is possible.
＜本実施形態の効果＞
このように構成した本実施形態に係る生体情報計測システム１００によれば、少なくとも脈波波形、ヘモグロビン濃度波形及び加速度脈波波形を同一画面上に同期させて表示しているので、ヘモグロビン濃度と脈波及び加速度脈波との相互の関係から、適切な健康管理を行うことができる。例えば、生理的変動に伴うヘモグロビン濃度と脈波及び加速度脈波との関係から、被験者の健康診断を行うことができる。
また、脈波波形を示すグラフ、ヘモグロビン濃度波形を示すグラフ及び加速度脈波波形を示すグラフを上下方向に一覧表示し、当該一覧表示した各グラフの時間軸の表示範囲が同じであるので、脳波波形、ヘモグロビン濃度波形及び加速度脈波波形の時間的な対応関係を一見して認識することができ、生体情報表示装置の使い勝手をより一層向上させることができる。
<Effect of this embodiment>
According to the biological information measuring system 100 according to the present embodiment configured as described above, since at least the pulse wave waveform, the hemoglobin concentration waveform, and the acceleration pulse wave waveform are displayed in synchronization on the same screen, the hemoglobin concentration and the pulse are displayed. Appropriate health care can be performed from the mutual relationship between the wave and the acceleration pulse wave. For example, a health examination of a subject can be performed from the relationship between the hemoglobin concentration associated with physiological fluctuations, the pulse wave, and the acceleration pulse wave.
In addition, the graph showing the pulse wave waveform, the graph showing the hemoglobin concentration waveform, and the graph showing the acceleration pulse wave waveform are listed in the vertical direction, and the display range of the time axis of each of the displayed graphs is the same. The temporal correspondence relationship between the waveform, the hemoglobin concentration waveform, and the acceleration pulse waveform can be recognized at a glance, and the usability of the biological information display device can be further improved.
＜その他の変形実施形態＞
なお、本発明は前記実施形態に限られるものではない。
<Other modified embodiments>
The present invention is not limited to the above embodiment.
例えば、生体情報生成部は、前記加速度脈波から推定血圧を算出し、推定血圧情報を生成するものであり、表示制御部が、各種波形に加えて推定血圧を表示するように攻勢しても良い。 For example, the biological information generation unit calculates estimated blood pressure from the acceleration pulse wave and generates estimated blood pressure information, and even if the display control unit attacks to display the estimated blood pressure in addition to various waveforms. good.
また、前記実施形態では、脈波波形、ヘモグロビン濃度波形及び加速度脈波波形の他にＳｐＯ２波形を同時に表示するものであったが、ＳｐＯ２波形を表示しないように構成しても良い。また、波形の一覧表示の配置順を変更可能に構成しても良い。 In the above-described embodiment, the SpO 2 waveform is simultaneously displayed in addition to the pulse waveform, the hemoglobin concentration waveform, and the acceleration pulse waveform. However, the SpO 2 waveform may not be displayed. Further, the arrangement order of the waveform list display may be changeable.
さらに、前記実施形態は、巻回タイプの計測ユニットについて説明したが、手首を手のひら側及び手の甲側から挟むクリップタイプの計測ユニットであっても良い。 Furthermore, although the said embodiment demonstrated the winding type measurement unit, the clip type measurement unit which pinches | interposes a wrist from the palm side and the back side of a hand may be sufficient.
その上、前記実施形態では、受光素子の受光面の高さ位置が発光素子の発光面の高さ位置よりも高くなるように構成されているが、逆の関係であっても良い。 In addition, in the embodiment, the height position of the light receiving surface of the light receiving element is configured to be higher than the height position of the light emitting surface of the light emitting element, but the reverse relationship may be used.
加えて、前記実施形態では、手首装着型パルスオキシメータであったが、指又は耳等のその他の生体部分に装着されるものであっても良いし、パルスオキシメータ以外の生体情報計測システムに適用することもできる。 In addition, in the above-described embodiment, the wrist-worn pulse oximeter is used. However, the pulse oximeter may be worn on other living body parts such as a finger or an ear, or may be used for a living body information measurement system other than the pulse oximeter. It can also be applied.
その他、本発明は前記実施形態に限られず、その趣旨を逸脱しない範囲で種々の変形が可能であるのは言うまでもない。 In addition, it goes without saying that the present invention is not limited to the above-described embodiment, and various modifications can be made without departing from the spirit of the present invention.
１００・・・生体情報計測システム
３３ｂ・・・生体情報生成部
３３ｃ・・・表示制御部
Ｇ１ ・・・脈波波形を示すグラフ
Ｇ２ ・・・ヘモグロビン濃度波形を示すグラフ
Ｇ３ ・・・加速度脈波波形を示すグラフ
DESCRIPTION OF SYMBOLS 100 ... Biological information measurement system 33b ... Biological information generation part 33c ... Display control part G1 ... Graph G2 which shows a pulse wave waveform ... Graph G3 which shows a hemoglobin concentration waveform ... Acceleration pulse wave Graph showing waveform
Claims (3)
前記生体情報生成部から前記生体情報を受け付けて、少なくとも脈波波形、ヘモグロビン濃度波形及び加速度脈波波形を同一画面上に同時に同期させて表示させる表示制御部とを備える生体情報表示装置。 A biological information generation unit that generates biological information including at least pulse wave information, hemoglobin concentration information, and acceleration pulse wave information using a light intensity signal obtained by the optical sensor;
A biological information display apparatus comprising: a display control unit that receives the biological information from the biological information generation unit and displays at least a pulse waveform, a hemoglobin concentration waveform, and an acceleration pulse waveform simultaneously in synchronization on the same screen.
前記表示制御部が、前記脈波波形、前記ヘモグロビン濃度波形及び前記加速度脈波波形とともに、前記推定血圧を表示するものである、請求項１記載の生体情報表示装置。 The biological information further includes estimated blood pressure,
The biological information display apparatus according to claim 1, wherein the display control unit displays the estimated blood pressure together with the pulse wave waveform, the hemoglobin concentration waveform, and the acceleration pulse wave waveform.
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