JP2015533790A5 - - Google Patents
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- Publication number
- JP2015533790A5 JP2015533790A5 JP2015530375A JP2015530375A JP2015533790A5 JP 2015533790 A5 JP2015533790 A5 JP 2015533790A5 JP 2015530375 A JP2015530375 A JP 2015530375A JP 2015530375 A JP2015530375 A JP 2015530375A JP 2015533790 A5 JP2015533790 A5 JP 2015533790A5
- Authority
- JP
- Japan
- Prior art keywords
- deficiency
- mitochondrial
- syndrome
- pharmaceutical composition
- respiratory chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000007812 deficiency Effects 0.000 claims 13
- 230000035806 respiratory chain Effects 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 230000002265 prevention Effects 0.000 claims 6
- 208000006136 Leigh Disease Diseases 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 230000002438 mitochondrial effect Effects 0.000 claims 5
- 208000011580 syndromic disease Diseases 0.000 claims 5
- 208000002155 Cytochrome-c Oxidase Deficiency Diseases 0.000 claims 4
- 208000017507 Leigh syndrome Diseases 0.000 claims 4
- 206010058799 Mitochondrial encephalomyopathy Diseases 0.000 claims 4
- 208000012268 mitochondrial disease Diseases 0.000 claims 3
- 208000023434 Alpers-Huttenlocher syndrome Diseases 0.000 claims 2
- 206010003591 Ataxia Diseases 0.000 claims 2
- 208000031229 Cardiomyopathies Diseases 0.000 claims 2
- 206010058892 Carnitine deficiency Diseases 0.000 claims 2
- 208000004986 Diffuse Cerebral Sclerosis of Schilder Diseases 0.000 claims 2
- 208000024412 Friedreich ataxia Diseases 0.000 claims 2
- 108700006159 Long-chain acyl-CoA dehydrogenase deficiency Proteins 0.000 claims 2
- 108700000232 Medium chain acyl CoA dehydrogenase deficiency Proteins 0.000 claims 2
- 201000002169 Mitochondrial myopathy Diseases 0.000 claims 2
- 208000014844 Mitochondrial neurogastrointestinal encephalomyopathy Diseases 0.000 claims 2
- 108700017825 Short chain Acyl CoA dehydrogenase deficiency Proteins 0.000 claims 2
- 108700005875 X-linked Creatine deficiency Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000004064 dysfunction Effects 0.000 claims 2
- 208000006443 lactic acidosis Diseases 0.000 claims 2
- 208000004687 long chain acyl-CoA dehydrogenase deficiency Diseases 0.000 claims 2
- 208000005548 medium chain acyl-CoA dehydrogenase deficiency Diseases 0.000 claims 2
- 201000011540 mitochondrial DNA depletion syndrome 4a Diseases 0.000 claims 2
- 230000004065 mitochondrial dysfunction Effects 0.000 claims 2
- 230000004898 mitochondrial function Effects 0.000 claims 2
- 230000000750 progressive effect Effects 0.000 claims 2
- 208000001392 short chain acyl-CoA dehydrogenase deficiency Diseases 0.000 claims 2
- 208000016505 systemic primary carnitine deficiency disease Diseases 0.000 claims 2
- 201000010866 very long chain acyl-CoA dehydrogenase deficiency Diseases 0.000 claims 2
- 102100039358 3-hydroxyacyl-CoA dehydrogenase type-2 Human genes 0.000 claims 1
- 201000007993 AGAT deficiency Diseases 0.000 claims 1
- 102000003966 Alpha-1-microglobulin Human genes 0.000 claims 1
- 101800001761 Alpha-1-microglobulin Proteins 0.000 claims 1
- 108700009893 Arginine-Glycine Amidinotransferase Deficiency Proteins 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 208000005359 Carnitine palmitoyl transferase 1A deficiency Diseases 0.000 claims 1
- 201000002929 Carnitine palmitoyltransferase II deficiency Diseases 0.000 claims 1
- 206010008025 Cerebellar ataxia Diseases 0.000 claims 1
- 208000010354 Coenzyme Q10 deficiency Diseases 0.000 claims 1
- 102000008013 Electron Transport Complex I Human genes 0.000 claims 1
- 108010089760 Electron Transport Complex I Proteins 0.000 claims 1
- 102000015782 Electron Transport Complex III Human genes 0.000 claims 1
- 108010024882 Electron Transport Complex III Proteins 0.000 claims 1
- 101000804964 Homo sapiens DNA polymerase subunit gamma-1 Proteins 0.000 claims 1
- 101001083553 Homo sapiens Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Proteins 0.000 claims 1
- 101000841267 Homo sapiens Long chain 3-hydroxyacyl-CoA dehydrogenase Proteins 0.000 claims 1
- 101000595929 Homo sapiens POLG alternative reading frame Proteins 0.000 claims 1
- 208000032242 L-Arginine:glycine amidinotransferase deficiency Diseases 0.000 claims 1
- 102100029107 Long chain 3-hydroxyacyl-CoA dehydrogenase Human genes 0.000 claims 1
- 108010027062 Long-Chain Acyl-CoA Dehydrogenase Proteins 0.000 claims 1
- 102000018653 Long-Chain Acyl-CoA Dehydrogenase Human genes 0.000 claims 1
- 102100021644 Long-chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 1
- 206010059396 Mitochondrial DNA depletion Diseases 0.000 claims 1
- 208000001769 Multiple Acyl Coenzyme A Dehydrogenase Deficiency Diseases 0.000 claims 1
- 208000036572 Myoclonic epilepsy Diseases 0.000 claims 1
- 102000006746 NADH Dehydrogenase Human genes 0.000 claims 1
- 108010086428 NADH Dehydrogenase Proteins 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- 102100035196 POLG alternative reading frame Human genes 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 208000013234 Pearson syndrome Diseases 0.000 claims 1
- 208000002009 Pyruvate Dehydrogenase Complex Deficiency Disease Diseases 0.000 claims 1
- 208000021886 Pyruvate carboxylase deficiency Diseases 0.000 claims 1
- 206010057430 Retinal injury Diseases 0.000 claims 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 claims 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 claims 1
- 208000034091 X-linked creatine transporter deficiency Diseases 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 201000004010 carnitine palmitoyltransferase I deficiency Diseases 0.000 claims 1
- 208000037887 cell injury Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 201000002997 creatine transporter deficiency Diseases 0.000 claims 1
- 208000026615 cytochrome-c oxidase deficiency disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 208000030533 eye disease Diseases 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 208000023692 inborn mitochondrial myopathy Diseases 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 108010007425 oligomycin sensitivity conferring protein Proteins 0.000 claims 1
- 210000001328 optic nerve Anatomy 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 201000006473 pyruvate decarboxylase deficiency Diseases 0.000 claims 1
- 208000015445 pyruvate dehydrogenase deficiency Diseases 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201270538 | 2012-09-05 | ||
| DKPA201270538 | 2012-09-05 | ||
| DKPA201270557 | 2012-09-12 | ||
| DKPA201270557 | 2012-09-12 | ||
| PCT/EP2013/068270 WO2014037390A1 (en) | 2012-09-05 | 2013-09-04 | Alpha-1-microglobulin for use in the treatment of mitochondria-related diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018157394A Division JP2018203756A (ja) | 2012-09-05 | 2018-08-24 | ミトコンドリア関連疾患の治療に使用するためのα−１−ミクログロブリン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015533790A JP2015533790A (ja) | 2015-11-26 |
| JP2015533790A5 true JP2015533790A5 (cg-RX-API-DMAC10.html) | 2016-09-08 |
Family
ID=49162118
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530375A Pending JP2015533790A (ja) | 2012-09-05 | 2013-09-04 | ミトコンドリア関連疾患の治療に使用するためのα−１−ミクログロブリン |
| JP2018157394A Pending JP2018203756A (ja) | 2012-09-05 | 2018-08-24 | ミトコンドリア関連疾患の治療に使用するためのα−１−ミクログロブリン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018157394A Pending JP2018203756A (ja) | 2012-09-05 | 2018-08-24 | ミトコンドリア関連疾患の治療に使用するためのα−１−ミクログロブリン |
Country Status (21)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016204360A (ja) * | 2015-02-25 | 2016-12-08 | エー１エム ファーマ エービーＡ１Ｍ Ｐｈａｒｍａ ＡＢ | 放射性核種療法における腎臓の保護に用いるためのアルファ−１−ミクログロブリン |
| WO2017144674A1 (en) * | 2016-02-25 | 2017-08-31 | A1M Pharma Ab | Alpha-1-microglobulin for use in the protection of kidneys in connection with use of contrast media |
| SG11201807352XA (en) * | 2016-03-18 | 2018-09-27 | A1M Pharma Ab | Novel alpha-1-microglobulin derived proteins and their use |
| GB2566516A (en) | 2017-09-15 | 2019-03-20 | Univ Oxford Innovation Ltd | Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria |
| CN109867717A (zh) * | 2019-04-01 | 2019-06-11 | 山西瑞亚力生物技术有限公司 | 一种血浆中α1微球蛋白的提取方法 |
| CN110452980B (zh) * | 2019-09-23 | 2023-07-28 | 武汉儿童医院 | 一种线粒体脑肌病诊断试剂盒及应用 |
| US20220362293A1 (en) * | 2019-09-25 | 2022-11-17 | Cytegen Corp. | Treatment of Mitochondrial Deficits and Age-Related Diseases Using Blood Products |
| CN115575646B (zh) * | 2022-11-21 | 2023-04-28 | 四川大学华西医院 | 一种代谢标志物组在制备预测癫痫发作的试剂盒中的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005051379A1 (en) * | 2003-11-26 | 2005-06-09 | Sanofi-Aventis Deutschland Gmbh | Tubular proteinuria as an indicator for elevated cardiovascular risk |
| NZ578077A (en) * | 2007-02-12 | 2012-04-27 | Stefan Hansson | Diagnosis of preeclampsia using free foetal haemoglobin |
| EP2300614B1 (en) * | 2008-02-04 | 2015-10-28 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Methods and compositions for treatment of mitochondrial disorders |
| DK2313106T3 (en) | 2008-07-18 | 2016-07-25 | A1M Pharma Ab | MEDICAL USE OF RADICAL binder and the antioxidant is alpha-1-microglobulin |
-
2013
- 2013-09-04 PL PL13759995T patent/PL2900254T3/pl unknown
- 2013-09-04 NZ NZ629621A patent/NZ629621A/en not_active IP Right Cessation
- 2013-09-04 EP EP13759995.7A patent/EP2900254B1/en not_active Not-in-force
- 2013-09-04 BR BR112015003957A patent/BR112015003957A2/pt not_active Application Discontinuation
- 2013-09-04 MX MX2015002604A patent/MX357656B/es active IP Right Grant
- 2013-09-04 AU AU2013311714A patent/AU2013311714C1/en not_active Ceased
- 2013-09-04 SG SG11201500669SA patent/SG11201500669SA/en unknown
- 2013-09-04 KR KR1020157005748A patent/KR20150047510A/ko not_active Ceased
- 2013-09-04 HR HRP20161364TT patent/HRP20161364T1/hr unknown
- 2013-09-04 PT PT137599957T patent/PT2900254T/pt unknown
- 2013-09-04 CA CA2881321A patent/CA2881321A1/en not_active Abandoned
- 2013-09-04 IN IN515DEN2015 patent/IN2015DN00515A/en unknown
- 2013-09-04 ES ES13759995.7T patent/ES2599034T3/es active Active
- 2013-09-04 EA EA201590503A patent/EA028963B1/ru not_active IP Right Cessation
- 2013-09-04 US US14/423,260 patent/US10226507B2/en not_active Expired - Fee Related
- 2013-09-04 CN CN201380043567.0A patent/CN104661673A/zh active Pending
- 2013-09-04 DK DK13759995.7T patent/DK2900254T3/en active
- 2013-09-04 JP JP2015530375A patent/JP2015533790A/ja active Pending
- 2013-09-04 HU HUE13759995A patent/HUE030559T2/en unknown
- 2013-09-04 WO PCT/EP2013/068270 patent/WO2014037390A1/en not_active Ceased
-
2015
- 2015-01-23 ZA ZA2015/00547A patent/ZA201500547B/en unknown
-
2018
- 2018-08-24 JP JP2018157394A patent/JP2018203756A/ja active Pending
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