JP2015523364A5 - - Google Patents

Info

Publication number

JP2015523364A5

JP2015523364A5 JP2015520652A JP2015520652A JP2015523364A5 JP 2015523364 A5 JP2015523364 A5 JP 2015523364A5 JP 2015520652 A JP2015520652 A JP 2015520652A JP 2015520652 A JP2015520652 A JP 2015520652A JP 2015523364 A5 JP2015523364 A5 JP 2015523364A5

Authority

JP

Japan

Prior art keywords

thiosulfate

agent

oxoprotective

sepsis

related condition

Prior art date

2013-07-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003795 chemical substances by application Substances 0.000 claims 12
• 206010040047 Sepsis Diseases 0.000 claims 11
• 239000000203 mixture Substances 0.000 claims 11
• AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims 10
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 8
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 8
• 239000003814 drug Substances 0.000 claims 6
• 235000019136 lipoic acid Nutrition 0.000 claims 6
• 229940124597 therapeutic agent Drugs 0.000 claims 6
• 229960002663 thioctic acid Drugs 0.000 claims 6
• 238000000034 method Methods 0.000 claims 5
• 108010024636 Glutathione Proteins 0.000 claims 4
• 229960003180 glutathione Drugs 0.000 claims 4
• -1 sulfide compound Chemical class 0.000 claims 4
• 150000003464 sulfur compounds Chemical class 0.000 claims 4
• AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 claims 3
• 235000019345 sodium thiosulphate Nutrition 0.000 claims 3
• DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 claims 3
• IZFHEQBZOYJLPK-SSDOTTSWSA-N (R)-dihydrolipoic acid Chemical compound OC(=O)CCCC[C@@H](S)CCS IZFHEQBZOYJLPK-SSDOTTSWSA-N 0.000 claims 2
• AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 claims 2
• 206010051379 Systemic Inflammatory Response Syndrome Diseases 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 150000002898 organic sulfur compounds Chemical class 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical group CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 1
• ZSILVJLXKHGNPL-UHFFFAOYSA-L S(=S)(=O)([O-])[O-].[Ag+2] Chemical compound S(=S)(=O)([O-])[O-].[Ag+2] ZSILVJLXKHGNPL-UHFFFAOYSA-L 0.000 claims 1
• 206010040070 Septic Shock Diseases 0.000 claims 1
• 241001061127 Thione Species 0.000 claims 1
• 229960004308 acetylcysteine Drugs 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• XYXNTHIYBIDHGM-UHFFFAOYSA-N ammonium thiosulfate Chemical compound [NH4+].[NH4+].[O-]S([O-])(=O)=S XYXNTHIYBIDHGM-UHFFFAOYSA-N 0.000 claims 1
• FAYYUXPSKDFLEC-UHFFFAOYSA-L calcium;dioxido-oxo-sulfanylidene-$l^{6}-sulfane Chemical compound [Ca+2].[O-]S([O-])(=O)=S FAYYUXPSKDFLEC-UHFFFAOYSA-L 0.000 claims 1
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 1
• 229960001231 choline Drugs 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• FGRVOLIFQGXPCT-UHFFFAOYSA-L dipotassium;dioxido-oxo-sulfanylidene-$l^{6}-sulfane Chemical compound [K+].[K+].[O-]S([O-])(=O)=S FGRVOLIFQGXPCT-UHFFFAOYSA-L 0.000 claims 1
• GRWZHXKQBITJKP-UHFFFAOYSA-L dithionite(2-) Chemical class [O-]S(=O)S([O-])=O GRWZHXKQBITJKP-UHFFFAOYSA-L 0.000 claims 1
• 229940083577 gold sodium thiosulfate Drugs 0.000 claims 1
• 150000004677 hydrates Chemical class 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• CQDMJJVHDPDPHO-UHFFFAOYSA-L magnesium;dioxido-oxo-sulfanylidene-$l^{6}-sulfane;hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=S CQDMJJVHDPDPHO-UHFFFAOYSA-L 0.000 claims 1
• 238000005259 measurement Methods 0.000 claims 1
• 238000012544 monitoring process Methods 0.000 claims 1
• GQPLMRYTRLFLPF-UHFFFAOYSA-N nitrous oxide Inorganic materials [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 claims 1
• 239000002243 precursor Substances 0.000 claims 1
• 230000036303 septic shock Effects 0.000 claims 1
• 229940048910 thiosulfate Drugs 0.000 claims 1
• 150000004764 thiosulfuric acid derivatives Chemical class 0.000 claims 1
• KZNBHWLDPGWJMM-UHFFFAOYSA-J trisodium;dioxido-oxo-sulfanylidene-$l^{6}-sulfane;gold(1+);dihydrate Chemical compound O.O.[Na+].[Na+].[Na+].[Au+].[O-]S([O-])(=O)=S.[O-]S([O-])(=O)=S KZNBHWLDPGWJMM-UHFFFAOYSA-J 0.000 claims 1
• 210000003462 vein Anatomy 0.000 claims 1