JP2015508411A5 - - Google Patents
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- JP2015508411A5 JP2015508411A5 JP2014551726A JP2014551726A JP2015508411A5 JP 2015508411 A5 JP2015508411 A5 JP 2015508411A5 JP 2014551726 A JP2014551726 A JP 2014551726A JP 2014551726 A JP2014551726 A JP 2014551726A JP 2015508411 A5 JP2015508411 A5 JP 2015508411A5
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- JP
- Japan
- Prior art keywords
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- subcoating
- nucleus
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000010410 layer Substances 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 7
- 229940079593 drugs Drugs 0.000 claims description 7
- 238000009498 subcoating Methods 0.000 claims description 5
- 210000004940 Nucleus Anatomy 0.000 claims description 4
- 230000002459 sustained Effects 0.000 claims description 4
- FASDKYOPVNHBLU-ZETCQYMHSA-N Pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 claims description 2
- 229960003089 Pramipexole Drugs 0.000 claims description 2
- RUOKEQAAGRXIBM-GFCCVEGCSA-N Rasagiline Chemical compound C1=CC=C2[C@H](NCC#C)CCC2=C1 RUOKEQAAGRXIBM-GFCCVEGCSA-N 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- 239000011247 coating layer Substances 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 229920000642 polymer Polymers 0.000 claims description 2
- 229960000245 rasagiline Drugs 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Description
したがって、ある実施形態では、本発明の医薬組成物は、（１）不活性小片核、（２）前記小片核に、ラサジリン、プラミペキソール、またはその両方、またはそれらの薬学的に許容される塩の活性物質からなり、任意に適切な結合剤および／またはフィルム形成ポリマーを混合し、さらに、任意に滑剤を混合した薬剤をコーティングした薬剤層、（３）任意に、前記した薬剤層にコーティングした隔離／保護するサブコーティング層、そして（４）サブコーティング層があるときにはサブコーティング層に、または薬剤層にコーティングした徐放コーティング層、を含む徐放性小片を含んでいる。
Claims (1)
- （１）不活性な小片核と、（２）前記小片核をコーティングし、プラミペキソール、ラサジリンまたはその両方、またはそれらの薬学的に許容される塩の活性成分、および、任意に適切な結合剤および／またはフィルム形成ポリマーが混合され、さらに、任意に滑剤が混合されてなる薬剤層と、（３）任意に、前記薬剤層を隔離／保護するサブコーティング層と、（４）サブコーティング層があるときにはサブコーティング層に、または薬剤層にコーティングされた徐放コーティング層と、を含む徐放性小片を含むことを特徴とする請求項６に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261585824P | 2012-01-12 | 2012-01-12 | |
| US61/585,824 | 2012-01-12 | ||
| PCT/IL2013/050025 WO2013105092A1 (en) | 2012-01-12 | 2013-01-10 | Fixed dose combination therapy of parkinson's disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015508411A JP2015508411A (ja) | 2015-03-19 |
| JP2015508411A5 true JP2015508411A5 (ja) | 2017-05-18 |
| JP6243351B2 JP6243351B2 (ja) | 2017-12-06 |
Family
ID=48781101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014551726A Active JP6243351B2 (ja) | 2012-01-12 | 2013-01-10 | パーキンソン病の固定投与量薬剤組合せ治療 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20150079187A1 (ja) |
| EP (1) | EP2802319B1 (ja) |
| JP (1) | JP6243351B2 (ja) |
| KR (2) | KR102276896B1 (ja) |
| CN (1) | CN104168896B (ja) |
| AU (1) | AU2013208653B2 (ja) |
| CA (1) | CA2860952C (ja) |
| CY (1) | CY1119793T1 (ja) |
| DK (1) | DK2802319T3 (ja) |
| ES (1) | ES2655676T3 (ja) |
| HK (1) | HK1203847A1 (ja) |
| HU (1) | HUE038029T2 (ja) |
| IL (1) | IL233572B (ja) |
| IN (1) | IN2014MN01568A (ja) |
| LT (1) | LT2802319T (ja) |
| MX (1) | MX360409B (ja) |
| NO (2) | NO2802319T3 (ja) |
| PL (1) | PL2802319T3 (ja) |
| PT (1) | PT2802319T (ja) |
| RS (1) | RS56742B1 (ja) |
| RU (1) | RU2642962C9 (ja) |
| WO (1) | WO2013105092A1 (ja) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104367565A (zh) * | 2014-11-21 | 2015-02-25 | 哈尔滨圣吉药业股份有限公司 | 一种盐酸普拉克索缓释微丸 |
| CN105147627B (zh) * | 2015-08-19 | 2019-04-12 | 天津红日药业股份有限公司 | 一种含有盐酸普拉克索的药物组合物及其制备方法 |
| WO2019036624A1 (en) * | 2017-08-17 | 2019-02-21 | Gu Zi Qiang | MONOAMINE PAMOATE SALT TYPE ANTI-PARKINSON AGENTS, PROCESS FOR PREPARING AND USING SAME |
| US20220064204A1 (en) * | 2018-12-19 | 2022-03-03 | Galecto Biotech Ab | Amorphous form of 5-bromopyridin-3-yl 3-deoxy-3-[4-(3,4,5-trifluorophenyl)-1h-1,2,3-triazol-1-yl]-1-thio-alpha-d-galactopyranoside |
| CN112915083A (zh) * | 2019-12-06 | 2021-06-08 | 上海医药集团股份有限公司 | 药物组合物、成套药盒及其应用 |
| WO2023112024A1 (en) * | 2021-12-14 | 2023-06-22 | Pharma Two B Ltd. | Method of treating parkinson's disease |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1485127E (pt) * | 2002-02-25 | 2011-09-07 | Elan Pharm Inc | Administração de agentes para o tratamento de inflamação |
| WO2005070428A1 (en) * | 2004-01-22 | 2005-08-04 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and a dopamine agonist |
| KR20060124712A (ko) * | 2004-02-20 | 2006-12-05 | 노파르티스 아게 | 신경퇴행 및 인지 장애를 치료하기 위한 ｄｐｐ ⅳ 억제제 |
| AU2005269416B2 (en) * | 2004-07-26 | 2011-07-28 | Teva Pharmaceutical Industries, Ltd. | Pharmaceutical dosage forms including rasagiline |
| WO2007117431A2 (en) * | 2006-04-03 | 2007-10-18 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline for the treatment of restless legs syndrome |
| JP2010525018A (ja) * | 2007-04-24 | 2010-07-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | プラミペキソール又はその医薬的に許容できる塩を含有する徐放性錠剤型製剤との組成物 |
| CA2726833C (en) * | 2008-06-06 | 2016-03-22 | Pharma Two B Ltd. | Pharmaceutical compositions for treatment of parkinson's disease |
| CN102186350A (zh) * | 2008-08-19 | 2011-09-14 | 诺普神经科学股份有限公司 | 使用(r)-普拉克索的组合物与方法 |
| PL2531181T3 (pl) * | 2010-02-03 | 2019-09-30 | Pharma Two B Ltd. | Preparaty rasagiliny o przedłużonym uwalnianiu i ich zastosowanie |
-
2013
- 2013-01-10 EP EP13736198.6A patent/EP2802319B1/en active Active
- 2013-01-10 DK DK13736198.6T patent/DK2802319T3/da active
- 2013-01-10 MX MX2014008537A patent/MX360409B/es active IP Right Grant
- 2013-01-10 LT LTEP13736198.6T patent/LT2802319T/lt unknown
- 2013-01-10 CA CA2860952A patent/CA2860952C/en active Active
- 2013-01-10 KR KR1020147022416A patent/KR102276896B1/ko active IP Right Grant
- 2013-01-10 CN CN201380014052.8A patent/CN104168896B/zh active Active
- 2013-01-10 RU RU2014132940A patent/RU2642962C9/ru active
- 2013-01-10 ES ES13736198.6T patent/ES2655676T3/es active Active
- 2013-01-10 RS RS20180050A patent/RS56742B1/sr unknown
- 2013-01-10 PT PT137361986T patent/PT2802319T/pt unknown
- 2013-01-10 HU HUE13736198A patent/HUE038029T2/hu unknown
- 2013-01-10 WO PCT/IL2013/050025 patent/WO2013105092A1/en active Application Filing
- 2013-01-10 JP JP2014551726A patent/JP6243351B2/ja active Active
- 2013-01-10 IN IN1568MUN2014 patent/IN2014MN01568A/en unknown
- 2013-01-10 US US14/372,067 patent/US20150079187A1/en not_active Abandoned
- 2013-01-10 KR KR1020207002459A patent/KR20200013791A/ko not_active Application Discontinuation
- 2013-01-10 AU AU2013208653A patent/AU2013208653B2/en active Active
- 2013-01-10 PL PL13736198T patent/PL2802319T3/pl unknown
- 2013-01-10 NO NO13736198A patent/NO2802319T3/no unknown
- 2013-09-30 NO NO13840443A patent/NO2901008T3/no unknown
-
2014
- 2014-07-09 IL IL233572A patent/IL233572B/en active IP Right Grant
-
2015
- 2015-05-18 HK HK15104685.5A patent/HK1203847A1/xx unknown
-
2018
- 2018-01-17 CY CY20181100061T patent/CY1119793T1/el unknown
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