JP2015503931A5 - - Google Patents
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- JP2015503931A5 JP2015503931A5 JP2014553478A JP2014553478A JP2015503931A5 JP 2015503931 A5 JP2015503931 A5 JP 2015503931A5 JP 2014553478 A JP2014553478 A JP 2014553478A JP 2014553478 A JP2014553478 A JP 2014553478A JP 2015503931 A5 JP2015503931 A5 JP 2015503931A5
- Authority
- JP
- Japan
- Prior art keywords
- oral product
- oral
- mouth
- stable polymer
- fiber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229960003291 chlorphenamine Drugs 0.000 description 1
- 229960003603 decitabine Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 229960003711 glyceryl trinitrate Drugs 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 229920000962 poly(amidoamine) Polymers 0.000 description 1
- 229960003111 prochlorperazine Drugs 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
Description
[本発明1001]
口腔中に全体的に受け入れ可能であるボディを含む、オーラル製品であって、該ボディが、
口内で安定なポリマーマトリックス、
該口内で安定なポリマーマトリックスに埋め込まれたセルロース系繊維、および
該ボディが該口腔内に受け入れられ唾液に曝された際に該ボディから放出されるように該口内で安定なポリマーマトリックス中に分散した、ニコチンまたはその誘導体
を含む、オーラル製品。
[本発明1002]
口内で安定なポリマーマトリックスがポリウレタンを含む、本発明1001のオーラル製品。
[本発明1003]
口内で安定なポリマーマトリックスがポリエステルを含む、本発明1001のオーラル製品。
[本発明1004]
口内で安定なポリマーマトリックスがポリアクリレートを含む、本発明1001のオーラル製品。
[本発明1005]
口内で安定なポリマーマトリックスが、ポリエチレン、SEBS、SBS、またはそれらの組み合わせを含む、本発明1001のオーラル製品。
[本発明1006]
口内で安定なポリマーマトリックス中に分散した可塑剤をさらに含む、本発明1001のオーラル製品。
[本発明1007]
可塑剤が、プロピレングリコール、グリセリン、植物油、トリグリセリド類、およびそれらの組み合わせからなる群より選択される、本発明1006のオーラル製品。
[本発明1008]
ボディ中に分散した甘味料をさらに含む、本発明1001のオーラル製品。
[本発明1009]
甘味料が、サッカリン、スクラロース、アスパルテーム、アセスルファムカリウム、およびそれらの組み合わせからなる群より選択される、本発明1008のオーラル製品。
[本発明1010]
ニコチンがタバコ由来のニコチンである、本発明1001のオーラル製品。
[本発明1011]
ニコチンが合成ニコチンである、本発明1001〜1009のいずれかのオーラル製品。
[本発明1012]
タバコ植物組織を実質的に含まない、本発明1001のオーラル製品。
[本発明1013]
ミネラル、ビタミン、補助食品、栄養補助食品、精力剤、無痛化剤、アミノ酸、ケメステティック剤（chemsthetic agent）、抗酸化剤、植物性薬剤（botanicals）、歯ホワイトニング剤、治療剤、およびそれらの組み合わせからなる群より選択される添加物をさらに含むオーラル製品であって、
ボディが成人消費者の口内に保持された際に放出されるように該添加物が該ボディ中に分散している、本発明1001のオーラル製品。
[本発明1014]
ボディが成人消費者の口内に配置された際に放出されるように該ボディ中に分散した、香味料
をさらに含む、本発明1001のオーラル製品。
[本発明1015]
香味料が、甘草、ウィンターグリーン、チェリーおよびベリータイプ香味料、ドランブイ、バーボン、スコッチ、ウイスキー、スペアミント、ペパーミント、ラベンダー、シナモン、カルダモン、セロリ（apium graveolens）、クローブ、カスカリラ、ナツメグ、サンダルウッド、ベルガモット、ゼラニウム、ハニーエッセンス、ローズ油、バニラ、レモン油、オレンジ油、和種ハッカ、カッシア、キャラウェイ、コニャック、ジャスミン、カモミール、メントール、イランイラン、セージ、フェンネル、ピメンタ、ショウガ、アニス、コリアンダー、コーヒー、ハッカ属の種由来のハッカ油、ならびにそれらの組み合わせからなる群より選択される、本発明1014のオーラル製品。
[本発明1016]
ニコチンが繊維・ポリマーマトリックス中に吸収されている、本発明1001のオーラル製品。
[本発明1017]
ボディが盾形である、本発明1001のオーラル製品。
[本発明1018]
ボディが5mm〜25mmの直径および1mm〜10mmの厚さを有する、本発明1001のオーラル製品。
[本発明1019]
ボディがセルロース系繊維を少なくとも10重量％含む、本発明1001のオーラル製品。
[本発明1020]
セルロース系繊維が非タバコセルロース系繊維である、本発明1001のオーラル製品。
[本発明1021]
セルロース系繊維が、テンサイ繊維、ウッドパルプ繊維、綿繊維、ふすま繊維、柑橘パルプ繊維、草繊維、ヤナギ繊維、およびポプラ繊維である、本発明1020のオーラル製品。
[本発明1022]
ボディが口内で安定なポリマーを少なくとも10重量％含む、本発明1001のオーラル製品。
[本発明1023]
ボディがニコチン0.1mg〜6mgを含む、本発明1001のオーラル製品。
[本発明1024]
ボディが95％未満の250N圧縮率を有する、本発明1001のオーラル製品。
[本発明1025]
ボディが80％未満の250N圧縮率を有する、本発明1001のオーラル製品。
[本発明1026]
ボディが45％〜90％の250N圧縮率を有する、本発明1001のオーラル製品。
[本発明1027]
ボディが99％未満の425N圧縮率を有する、本発明1001のオーラル製品。
[本発明1028]
ボディが60％〜98％の425N圧縮率を有する、本発明1001のオーラル製品。
[本発明1029]
ボディが少なくとも20％の弾性率を有する、本発明1001のオーラル製品。
[本発明1030]
ボディが少なくとも70％の弾性率を有する、本発明1001のオーラル製品。
[本発明1031]
ボディが75％〜90％の弾性率を有する、本発明1001のオーラル製品。
[本発明1032]
抗酸化剤をさらに含む、本発明1001のオーラル製品。
[本発明1033]
抗酸化剤を0.01重量％〜5.0重量％含む、本発明1032のオーラル製品。
[本発明1034]
抗酸化剤が、パルミチン酸アスコルビル、BHT、アスコルビン酸、アスコルビン酸ナトリウム、クエン酸モノステロール、トコフェロール類、没食子酸プロピル、tert-ブチルヒドロキノン（TBHQ）、ブチル化ヒドロキシアニソール（BHA）、ビタミンE、およびそれらの組み合わせから選択される、本発明1032のオーラル製品。
[本発明1035]
抗酸化剤がビタミンCの誘導体である、本発明1032のオーラル製品。
[本発明1036]
抗酸化剤がパルミチン酸アスコルビルである、本発明1032のオーラル製品。
[本発明1037]
可溶性繊維をさらに含む、本発明1032のオーラル製品。
[本発明1038]
可溶性繊維とセルロース系繊維との比が1:60〜60:1である、本発明1037のオーラル製品。
[本発明1039]
可溶性繊維がマルトデキストリンを含む、本発明1037のオーラル製品。
[本発明1040]
可溶性繊維がトウモロコシ由来である、本発明1037のオーラル製品。
[本発明1041]
セルロース系繊維がその中に分散している口内で安定なポリマーを押出し成形する工程、および
該押出し成形する工程の最中または後でニコチンまたはその誘導体を該口内で安定なポリマー内に分散させる工程
を含む、オーラル製品を形成する方法。
[本発明1042]
押出し成形された口内で安定なポリマーとセルロース系繊維との混合物を、成人消費者の口腔中に少なくとも部分的に受け入れられるようなサイズの個々のオーラル製品へと切断する工程をさらに含む、本発明1041の方法。
[本発明1043]
分散させる工程が押出し成形する工程中に実施される、本発明1041の方法。
[本発明1044]
ニコチンをセルロース系繊維と混合する、本発明1043の方法。
[本発明1045]
分散させる工程が押出し成形する工程の後に実施される、本発明1041の方法。
[本発明1046]
口内で安定なポリマーが、押出し成形する工程中にその中に混合される可塑剤を含む、本発明1041の方法。
[本発明1047]
押出し成形する工程の最中または後で香味料を加えることをさらに含む、本発明1041の方法。
[本発明1048]
押出し成形する工程中に抗酸化剤を加えることをさらに含む、本発明1041の方法。
[本発明1049]
押出し成形後の香味付けプロセス中に抗酸化剤を加えることをさらに含む、本発明1041の方法。
[本発明1050]
押出し成形する工程中に可溶性繊維を加えることをさらに含む、本発明1041の方法。
[本発明1051]
口内で安定なポリマーを押出し成形する工程、
該押出し成形する工程の最中または後でニコチンを該口内で安定なポリマー内に分散させる工程、および
該押出し成形された口内で安定なポリマーを切断して個々のオーラル製品を形成する工程
を含む、オーラル製品を形成する方法。
[本発明1052]
個々のオーラル製品が、口腔内で操作される際に、柔軟でありかつ形状記憶性を有する、本発明1051の方法。
[本発明1053]
口内で安定なポリマーを押出し成形する工程、
該押出し成形する工程の最中または後でニコチンを該口内で安定なポリマー内に分散させる工程、および
該押出し成形された口内で安定なポリマーを成形して個々のオーラル製品を形成する工程
を含む、オーラル製品を形成する方法。
[本発明1054]
口腔中に全体的に受け入れ可能であるボディを含むオーラル製品であって、該ボディが、
該ボディ中に分散したニコチンまたはその誘導体、
該ボディ中に分散した抗酸化剤
を含み、
該オーラル製品が、該オーラル製品を25℃および相対湿度65％で2週間ねかせたのち、ニコチンの0.50％未満がニコチンN-オキシドに転換するように構成されている、オーラル製品。
[本発明1055]
ボディが、抗酸化剤0.01重量％〜1.0重量％およびニコチン0.1mg〜6mgを含む、本発明1054のオーラル製品。
[本発明1056]
抗酸化剤が、パルミチン酸アスコルビル、BHT、アスコルビン酸、アスコルビン酸ナトリウム、ビタミンCの誘導体、クエン酸モノステロール、トコフェロール類、没食子酸プロピル、tert-ブチルヒドロキノン（TBHQ）、ブチル化ヒドロキシアニソール（BHA）、ビタミンE、およびそれらの誘導体もしくは組み合わせである、本発明1054のオーラル製品。
[本発明1057]
ボディが、口内で安定なポリウレタンマトリックスおよび該マトリックス内の可溶性繊維と不溶性繊維との組み合わせを含み、ニコチンおよび抗酸化剤が該マトリックス内に分散している、本発明1054のオーラル製品。
[本発明1058]
口腔中に全体的に受け入れ可能であるボディを含むオーラル製品であって、該ボディが、
口内で安定なポリマーマトリックス、
該口内で安定なポリマーマトリックスに埋め込まれたセルロース系繊維、および
該ボディが該口腔内に受け入れられ唾液に曝された際に該ボディから放出されるように該口内で安定なポリマーマトリックス中に分散した、添加物
を含む、オーラル製品。
[本発明1059]
口内で安定なポリマーマトリックスがポリウレタンを含む、本発明1058のオーラル製品。
[本発明1060]
ボディ中に分散した甘味料をさらに含む、本発明1058のオーラル製品。
[本発明1061]
添加物が、ミネラル、ビタミン、補助食品、栄養補助食品、精力剤、無痛化剤、アミノ酸、ケメステティック剤、抗酸化剤、植物性薬剤、歯ホワイトニング剤、治療剤、およびそれらの組み合わせからなる群より選択される、本発明1058のオーラル製品。
[本発明1062]
添加物が、Gerd、ブプレノルフィン、ニトログリセリン、ジクロフェナク、フェンタニル、カルバマゼピン、ガランタミン、アシクロビル、ポリアミドアミンナノ粒子、クロルフェニラミン、テストステロン、エストラジオール、プロゲステロン、カルシトニン、フルオロウラシル、ナルトレキソン、オダンセトロン、デシタビン、セレギリン、ラモトリギン、プロクロルペラジン、およびそれらの組み合わせからなる群より選択される治療剤である、本発明1058のオーラル製品。
[本発明1063]
ボディが消費者の口内に保持された際に放出されるように該ボディ中に分散した、香味料
をさらに含む、本発明1058のオーラル製品。
[本発明1064]
ボディが45％〜90％の250N圧縮率を有する、本発明1058のオーラル製品。
[本発明1065]
ボディが60％〜98％の425N圧縮率を有する、本発明1058のオーラル製品。
[本発明1066]
ボディが75％〜90％の弾性率を有する、本発明1058のオーラル製品。
[本発明1067]
セルロース系繊維がその中に分散している口内で安定なポリマーを押出し成形する工程、および
該押出し成形する工程の最中または後で添加物を該口内で安定なポリマー内に分散させる工程であって、該添加物が、香味料、甘味料、カフェイン、またはそれらの組み合わせから選択される、工程
を含む、オーラル製品を形成する方法。
[本発明1068]
口内で安定なポリマーを押出し成形する工程、
該押出し成形する工程の最中または後で添加物を該口内で安定なポリマー内に分散させる工程、および
該押出し成形された口内で安定なポリマーを切断して個々のオーラル製品を形成する工程
を含む、オーラル製品を形成する方法。
[本発明1069]
個々のオーラル製品が45％〜90％の250N圧縮率を有する、本発明1068の方法。
[本発明1070]
口内で安定なポリマーを押出し成形する工程、
該押出し成形する工程の最中または後で添加物を該口内で安定なポリマー内に分散させる工程、および
該押出し成形された口内で安定なポリマーを成形して個々のオーラル製品を形成する工程
を含む、オーラル製品を形成する方法。
[本発明1071]
個々のオーラル製品が45％〜90％の250N圧縮率を有する、本発明1070の方法。
[本発明1072]
口腔中に全体的に受け入れ可能であるボディを含むオーラル製品であって、該ボディが、
口内で安定なポリマーマトリックス、
該口内で安定なポリマーマトリックスに埋め込まれた、可溶成分が除去された（exhausted）タバコ繊維、および
該ボディが該口腔内に受け入れられ唾液に曝された際に該ボディから放出されるように該口内で安定なポリマーマトリックス中に分散した、添加物
を含む、オーラル製品。
[本発明1073]
口内で安定なポリマーマトリックスがポリウレタンを含む、本発明1072のオーラル製品。
[本発明1074]
ボディ中に分散した甘味料をさらに含む、本発明1072のオーラル製品。
[本発明1075]
添加物がニコチンまたはその誘導体である、本発明1072のオーラル製品。
[本発明1076]
非タバコセルロース系繊維をさらに含む、本発明1072のオーラル製品。
[本発明1077]
添加物が、ミネラル、ビタミン、補助食品、栄養補助食品、精力剤、無痛化剤、アミノ酸、ケメステティック剤、抗酸化剤、植物性薬剤、歯ホワイトニング剤、治療剤、およびそれらの組み合わせからなる群より選択される、本発明1072のオーラル製品。
[本発明1078]
ボディが成人消費者の口内に保持された際に放出されるように該ボディまたは可溶成分が除去されたタバコ繊維中に分散した、香味料
をさらに含む、本発明1072のオーラル製品。
[本発明1079]
ボディが盾形である、本発明1001のオーラル製品。
[本発明1080]
ボディが、可溶成分が除去されたタバコ繊維を少なくとも10重量％含む、本発明1072のオーラル製品。
[本発明1081]
ボディが口内で安定なポリマーを少なくとも10重量％含む、本発明1072のオーラル製品。
[本発明1082]
ボディがニコチン0.1mg〜6mgを含む、本発明1072のオーラル製品。
[本発明1083]
ボディが45％〜90％の250N圧縮率を有する、本発明1072のオーラル製品。
[本発明1084]
ボディが60％〜98％の425N圧縮率を有する、本発明1072のオーラル製品。
[本発明1085]
ボディが75％〜90％の弾性率を有する、本発明1072のオーラル製品。
[本発明1086]
可溶成分が除去されたタバコ繊維がその中に分散している口内で安定なポリマーを押出し成形する工程、および
該押出し成形する工程の最中または後で添加物を該口内で安定なポリマー内に分散させる工程であって、該添加物が、香味料、甘味料、ニコチン、カフェイン、またはそれらの組み合わせから選択される、工程
を含む、オーラル製品を形成する方法。
[本発明1087]
口腔中に全体的に受け入れ可能であるボディを含むオーラルタバコ製品であって、該ボディが、
口内で安定なポリマーマトリックス、および
該口内で安定なポリマーマトリックスに埋め込まれたタバコ繊維
を含み、該ボディが45％〜95％の250N圧縮率を有する、オーラルタバコ製品。
[本発明1088]
口腔中に全体的に受け入れ可能であるボディを含むオーラルタバコ製品であって、該ボディが、
口内で安定なポリマーマトリックス、および
該口内で安定なポリマーマトリックスに埋め込まれたタバコ繊維
を含み、該ボディが60％〜99％の425N圧縮率を有する、オーラルタバコ製品。
[本発明1089]
口腔中に全体的に受け入れ可能であるボディを含むオーラルタバコ製品であって、該ボディが、
口内で安定なポリマーマトリックス、および
該口内で安定なポリマーマトリックスに埋め込まれたタバコ繊維
を含み、該ボディが少なくとも20％の弾性率を有する、オーラルタバコ製品。
[本発明1090]
口内で安定なポリマーマトリックスがポリウレタンを含む、本発明1087〜1089のいずれかのオーラルタバコ製品。
[本発明1091]
口内で安定なポリマーマトリックス中に分散した可塑剤をさらに含む、本発明1087〜1089のいずれかのオーラルタバコ製品。
[本発明1092]
ボディが盾形である、本発明1087〜1089のいずれかのオーラルタバコ製品。
[本発明1093]
ボディがタバコ繊維を少なくとも10重量％含む、本発明1087〜1089のいずれかのオーラルタバコ製品。
[本発明1094]
非タバコセルロース系繊維をさらに含む、本発明1087〜1089のいずれかのオーラルタバコ製品。
[本発明1095]
ボディが口内で安定なポリマーを少なくとも10重量％含む、本発明1087〜1089のいずれかのオーラルタバコ製品。
[本発明1096]
ボディが45％〜90％の250N圧縮率を有する、本発明1087〜1089のいずれかのオーラルタバコ製品。
[本発明1097]
ボディが60％〜98％の425N圧縮率を有する、本発明1087〜1089のいずれかのオーラルタバコ製品。
[本発明1098]
ボディが75％〜90％の弾性率を有する、本発明1087〜1089のいずれかのオーラルタバコ製品。
[本発明1099]
抗酸化剤をさらに含む、本発明1087〜1089のいずれかのオーラルタバコ製品。
[本発明1100]
抗酸化剤を0.01重量％〜5.0重量％含む、本発明1099のオーラルタバコ製品。
[本発明1101]
可溶性繊維をさらに含む、本発明1087〜1089のいずれかのオーラルタバコ製品。
[本発明1102]
可溶性繊維とセルロース系繊維との比が1:60〜60:1である、本発明1101のオーラルタバコ製品。
[本発明1103]
可溶性繊維がマルトデキストリンを含む、本発明1101のオーラル製品。
[本発明1104]
タバコ繊維がその中に分散している口内で安定なポリマーを押出し成形する工程、および
該押出し成形された口内で安定なポリマーとタバコ繊維との混合物を、成人タバコ消費者の口腔中に少なくとも部分的に受け入れられるようなサイズの個々のオーラルタバコ製品へと切断する工程
を含む、オーラルタバコ製品を形成する方法。
[本発明1105]
押出し成形する工程中に可溶性繊維を加えることをさらに含む、本発明1104の方法。
本明細書に記載される主題の一つまたは複数の態様の詳細は添付図面および以下の詳細な説明に述べられる。主題の他の特徴、局面、および利点は、詳細な説明、図面、および特許請求の範囲から明らかになるであろう。
[Invention 1001]
An oral product comprising a body that is generally acceptable in the oral cavity, the body comprising:
Mouth-stable polymer matrix,
Cellulosic fibers embedded in the mouth-stable polymer matrix, and
Nicotine or a derivative thereof dispersed in a polymer matrix that is stable in the mouth such that the body is received in the oral cavity and released from the body when exposed to saliva
Including oral products.
[Invention 1002]
Oral product of this invention 1001, wherein the mouth-stable polymer matrix comprises polyurethane.
[Invention 1003]
The oral product of the invention 1001, wherein the mouth-stable polymer matrix comprises polyester.
[Invention 1004]
The oral product of the invention 1001, wherein the mouth-stable polymer matrix comprises a polyacrylate.
[Invention 1005]
The oral product of the invention 1001, wherein the mouth-stable polymer matrix comprises polyethylene, SEBS, SBS, or combinations thereof.
[Invention 1006]
The oral product of the invention 1001 further comprising a plasticizer dispersed in a mouth-stable polymer matrix.
[Invention 1007]
The oral product of the invention 1006, wherein the plasticizer is selected from the group consisting of propylene glycol, glycerin, vegetable oils, triglycerides, and combinations thereof.
[Invention 1008]
The oral product of the invention 1001 further comprising a sweetener dispersed in the body.
[Invention 1009]
The oral product of this invention 1008, wherein the sweetener is selected from the group consisting of saccharin, sucralose, aspartame, acesulfame potassium, and combinations thereof.
[Invention 1010]
The oral product of the present invention 1001, wherein the nicotine is tobacco-derived nicotine.
[Invention 1011]
The oral product of any of the inventions 1001-1009, wherein the nicotine is synthetic nicotine.
[Invention 1012]
The oral product of the invention 1001 substantially free of tobacco plant tissue.
[Invention 1013]
Minerals, vitamins, dietary supplements, nutritional supplements, vigorous agents, soothing agents, amino acids, chemsthetic agents, antioxidants, botanicals, tooth whitening agents, therapeutic agents, and their An oral product further comprising an additive selected from the group consisting of a combination,
The oral product of the invention 1001, wherein the additive is dispersed in the body such that it is released when the body is held in the mouth of an adult consumer.
[Invention 1014]
A flavorant dispersed in the body such that the body is released when placed in the mouth of an adult consumer
The oral product of the present invention 1001 further comprising:
[Invention 1015]
Flavors include licorice, winter green, cherry and berry type flavors, drunk buoy, bourbon, scotch, whiskey, spearmint, peppermint, lavender, cinnamon, cardamom, celery (apium graveolens), cloves, cascarilla, nutmeg, sandalwood, bergamot , Geranium, honey essence, rose oil, vanilla, lemon oil, orange oil, Japanese mint, cassia, caraway, cognac, jasmine, chamomile, menthol, ylang ylang, sage, fennel, pimenta, ginger, anise, coriander, coffee Oral product of the invention 1014 selected from the group consisting of mint oils from mint species, and combinations thereof.
[Invention 1016]
The oral product of the present invention 1001, wherein nicotine is absorbed in a fiber-polymer matrix.
[Invention 1017]
The oral product of the present invention 1001 whose body is a shield shape.
[Invention 1018]
The oral product of the invention 1001, wherein the body has a diameter of 5 mm to 25 mm and a thickness of 1 mm to 10 mm.
[Invention 1019]
The oral product of the present invention 1001, wherein the body comprises at least 10% by weight of cellulosic fibers.
[Invention 1020]
The oral product of the invention 1001 wherein the cellulosic fiber is a non-tobacco cellulosic fiber.
[Invention 1021]
The oral product of the invention 1020 wherein the cellulosic fibers are sugar beet fiber, wood pulp fiber, cotton fiber, bran fiber, citrus pulp fiber, grass fiber, willow fiber, and poplar fiber.
[Invention 1022]
The oral product of the invention 1001, wherein the body comprises at least 10% by weight of a mouth-stable polymer.
[Invention 1023]
The oral product of the invention 1001 wherein the body contains 0.1 mg to 6 mg of nicotine.
[Invention 1024]
The oral product of the present invention 1001, wherein the body has a 250N compression ratio of less than 95%.
[Invention 1025]
The oral product of the present invention 1001, whose body has a 250N compression ratio of less than 80%.
[Invention 1026]
The oral product of the present invention 1001, whose body has a compression rate of 250N between 45% and 90%.
[Invention 1027]
The oral product of the present invention 1001, wherein the body has a 425N compression ratio of less than 99%.
[Invention 1028]
The oral product of the present invention 1001, whose body has a 425N compression ratio of 60% to 98%.
[Invention 1029]
The oral product of the present invention 1001, wherein the body has an elastic modulus of at least 20%.
[Invention 1030]
The oral product of the present invention 1001, wherein the body has an elastic modulus of at least 70%.
[Invention 1031]
The oral product of the present invention 1001, wherein the body has an elastic modulus of 75% to 90%.
[Invention 1032]
The oral product of the present invention 1001, further comprising an antioxidant.
[Invention 1033]
The oral product of the invention 1032 containing 0.01% to 5.0% by weight of an antioxidant.
[Invention 1034]
Antioxidants include ascorbyl palmitate, BHT, ascorbic acid, sodium ascorbate, monosterol citrate, tocopherols, propyl gallate, tert-butylhydroquinone (TBHQ), butylated hydroxyanisole (BHA), vitamin E, and The oral product of the present invention 1032 selected from a combination thereof.
[Invention 1035]
The oral product of the invention 1032 wherein the antioxidant is a derivative of vitamin C.
[Invention 1036]
The oral product of the invention 1032 wherein the antioxidant is ascorbyl palmitate.
[Invention 1037]
The oral product of the invention 1032 further comprising a soluble fiber.
[Invention 1038]
The oral product of the invention 1037 wherein the ratio of soluble fiber to cellulosic fiber is from 1:60 to 60: 1.
[Invention 1039]
The oral product of the invention 1037, wherein the soluble fiber comprises maltodextrin.
[Invention 1040]
The oral product of the invention 1037, wherein the soluble fiber is derived from corn.
[Invention 1041]
Extruding a stable polymer in the mouth having cellulosic fibers dispersed therein; and
Dispersing nicotine or a derivative thereof in a stable polymer in the mouth during or after the extrusion step
A method of forming an oral product, comprising:
[Invention 1042]
The present invention further comprises the step of cutting the extruded mouth stable polymer and cellulosic fiber mixture into individual oral products sized to be at least partially acceptable in the oral cavity of an adult consumer. 1041 method.
[Invention 1043]
The method of 1041 of the present invention, wherein the dispersing step is performed during the extrusion step.
[Invention 1044]
The method of the present invention 1043, wherein nicotine is mixed with cellulosic fibers.
[Invention 1045]
The method of 1041 of the present invention, wherein the dispersing step is performed after the extruding step.
[Invention 1046]
The method of the present invention 1041, wherein the mouth-stable polymer comprises a plasticizer mixed therein during the extrusion process.
[Invention 1047]
The method of the present invention 1041, further comprising adding a flavor during or after the extruding step.
[Invention 1048]
The method of the present invention 1041, further comprising adding an antioxidant during the extruding step.
[Invention 1049]
The method of 1041 of this invention further comprising adding an antioxidant during the post-extrusion flavoring process.
[Invention 1050]
The method of claim 1041, further comprising adding soluble fiber during the extruding step.
[Invention 1051]
Extruding a stable polymer in the mouth,
Dispersing nicotine in the mouth-stable polymer during or after the extruding step; and
Cutting the stable polymer in the extruded mouth to form individual oral products
A method of forming an oral product, comprising:
[Invention 1052]
The method of the present invention 1051, wherein the individual oral product is flexible and has shape memory when manipulated in the oral cavity.
[Invention 1053]
Extruding a stable polymer in the mouth,
Dispersing nicotine in the mouth-stable polymer during or after the extruding step; and
Forming a stable polymer in the extruded mouth to form individual oral products;
A method of forming an oral product, comprising:
[Invention 1054]
An oral product comprising a body that is generally acceptable in the oral cavity, the body comprising:
Nicotine or a derivative thereof dispersed in the body,
Antioxidants dispersed in the body
Including
An oral product wherein the oral product is configured such that less than 0.50% of nicotine is converted to nicotine N-oxide after aging the oral product at 25 ° C. and 65% relative humidity for 2 weeks.
[Invention 1055]
Oral product of this invention 1054 wherein the body comprises 0.01% to 1.0% by weight of an antioxidant and 0.1 mg to 6 mg of nicotine.
[Invention 1056]
Antioxidants include ascorbyl palmitate, BHT, ascorbic acid, sodium ascorbate, vitamin C derivatives, monosterol citrate, tocopherols, propyl gallate, tert-butylhydroquinone (TBHQ), butylated hydroxyanisole (BHA) Oral product of the present invention 1054 which is vitamin E, and derivatives or combinations thereof.
[Invention 1057]
The oral product of this invention 1054, wherein the body comprises a mouth-stable polyurethane matrix and a combination of soluble and insoluble fibers in the matrix, wherein nicotine and antioxidants are dispersed within the matrix.
[Invention 1058]
An oral product comprising a body that is generally acceptable in the oral cavity, the body comprising:
Mouth-stable polymer matrix,
Cellulosic fibers embedded in the mouth-stable polymer matrix, and
An additive dispersed in a mouth-stable polymer matrix such that the body is received in the oral cavity and released from the body when exposed to saliva
Including oral products.
[Invention 1059]
The oral product of the invention 1058, wherein the mouth-stable polymer matrix comprises polyurethane.
[Invention 1060]
The oral product of this invention 1058 further comprising a sweetener dispersed in the body.
[Invention 1061]
Additives consist of minerals, vitamins, dietary supplements, nutritional supplements, tonics, soothing agents, amino acids, chemestics, antioxidants, botanicals, tooth whitening agents, therapeutic agents, and combinations thereof Oral product of the present invention 1058 selected from the group.
[Invention 1062]
Additives include Gerd, Buprenorphine, Nitroglycerin, Diclofenac, Fentanyl, Carbamazepine, Galantamine, Acyclovir, Polyamidoamine nanoparticles, Chlorpheniramine, Testosterone, Estradiol, Progesterone, Calcitonin, Fluorouracil, Naltrexone, Odansetron, Decitabine, Selegiline, Selegiline, The oral product of the invention 1058, which is a therapeutic agent selected from the group consisting of prochlorperazine, and combinations thereof.
[Invention 1063]
A flavorant dispersed in the body such that it is released when the body is held in the consumer's mouth
The oral product of the present invention 1058 further comprising:
[Invention 1064]
An oral product of the present invention 1058 having a body with a 250N compression ratio of 45% to 90%.
[Invention 1065]
The oral product of the present invention 1058, wherein the body has a 425N compression ratio of 60% to 98%.
[Invention 1066]
The oral product of the present invention 1058, wherein the body has an elastic modulus of 75% to 90%.
[Invention 1067]
Extruding a stable polymer in the mouth having cellulosic fibers dispersed therein; and
Dispersing an additive in the mouth-stable polymer during or after the extruding step, wherein the additive is selected from a flavoring agent, sweetener, caffeine, or combinations thereof Process
A method of forming an oral product, comprising:
[Invention 1068]
Extruding a stable polymer in the mouth,
Dispersing additives into the stable polymer in the mouth during or after the extruding step; and
Cutting the stable polymer in the extruded mouth to form individual oral products
A method of forming an oral product, comprising:
[Invention 1069]
The method of the present invention 1068, wherein the individual oral products have a 250N compression ratio of 45% to 90%.
[Invention 1070]
Extruding a stable polymer in the mouth,
Dispersing additives into the stable polymer in the mouth during or after the extruding step; and
Forming a stable polymer in the extruded mouth to form individual oral products;
A method of forming an oral product, comprising:
[Invention 1071]
The method of the present invention 1070, wherein individual oral products have a 250N compression ratio of 45% to 90%.
[Invention 1072]
An oral product comprising a body that is generally acceptable in the oral cavity, the body comprising:
Mouth-stable polymer matrix,
Tobacco fibers embedded in a mouth-stable polymer matrix and exhausted from soluble components; and
An additive dispersed in a mouth-stable polymer matrix such that the body is received in the oral cavity and released from the body when exposed to saliva
Including oral products.
[Invention 1073]
Oral product of this invention 1072 wherein the mouth-stable polymer matrix comprises polyurethane.
[Invention 1074]
The oral product of this invention 1072 further comprising a sweetener dispersed in the body.
[Invention 1075]
The oral product of the invention 1072 wherein the additive is nicotine or a derivative thereof.
[Invention 1076]
The oral product of this invention 1072 further comprising non-tobacco cellulosic fibers.
[Invention 1077]
Additives consist of minerals, vitamins, dietary supplements, nutritional supplements, tonics, soothing agents, amino acids, chemestics, antioxidants, botanicals, tooth whitening agents, therapeutic agents, and combinations thereof Oral product of the present invention 1072 selected from the group.
[Invention 1078]
A flavorant dispersed in tobacco fibers from which the body or soluble components have been removed so that the body is released when held in the mouth of an adult consumer
The oral product of the present invention 1072 further comprising:
[Invention 1079]
The oral product of the present invention 1001 whose body is a shield shape.
[Invention 1080]
Oral product of this invention 1072 wherein the body comprises at least 10% by weight of tobacco fibers from which soluble components have been removed.
[Invention 1081]
Oral product of this invention 1072 wherein the body comprises at least 10% by weight of a mouth-stable polymer.
[Invention 1082]
Oral product of this invention 1072 wherein the body contains 0.1 mg to 6 mg of nicotine.
[Invention 1083]
Oral product of the present invention 1072 with a body having a 250N compression ratio of 45% to 90%.
[Invention 1084]
Oral product of the present invention 1072, wherein the body has a 425N compression ratio of 60% to 98%.
[Invention 1085]
The oral product of the present invention 1072 wherein the body has an elastic modulus of 75% to 90%.
[Invention 1086]
Extruding a stable polymer in the mouth having tobacco fibers from which soluble components have been removed dispersed therein; and
Dispersing the additive in the mouth-stable polymer during or after the extruding step, wherein the additive comprises a flavorant, sweetener, nicotine, caffeine, or combinations thereof Selected, process
A method of forming an oral product, comprising:
[Invention 1087]
An oral tobacco product comprising a body that is generally acceptable in the oral cavity, the body comprising:
A mouth-stable polymer matrix, and
Tobacco fibers embedded in a mouth-stable polymer matrix
Oral tobacco product, wherein the body has a 250N compression ratio of 45% to 95%.
[Invention 1088]
An oral tobacco product comprising a body that is generally acceptable in the oral cavity, the body comprising:
A mouth-stable polymer matrix, and
Tobacco fibers embedded in a mouth-stable polymer matrix
Oral tobacco product, wherein the body has a 425N compression ratio of 60% to 99%.
[Invention 1089]
An oral tobacco product comprising a body that is generally acceptable in the oral cavity, the body comprising:
A mouth-stable polymer matrix, and
Tobacco fibers embedded in a mouth-stable polymer matrix
An oral tobacco product, wherein the body has an elastic modulus of at least 20%.
[Invention 1090]
The oral tobacco product of any of the present invention 1087-1089, wherein the mouth-stable polymer matrix comprises polyurethane.
[Invention 1091]
The oral tobacco product of any of the present invention 1087-1089, further comprising a plasticizer dispersed in a mouth-stable polymer matrix.
[Invention 1092]
The oral tobacco product of any of the present invention 1087-1089, wherein the body is a shield.
[Invention 1093]
The oral tobacco product of any of the present invention 1087-1089, wherein the body comprises at least 10% by weight tobacco fiber.
[Invention 1094]
The oral tobacco product of any of the present invention 1087-1089, further comprising non-tobacco cellulosic fibers.
[Invention 1095]
Oral tobacco product according to any of the present invention 1087-1089, wherein the body comprises at least 10% by weight of a mouth-stable polymer.
[Invention 1096]
The oral tobacco product of any of the present invention 1087-1089, wherein the body has a 250N compression ratio of 45% -90%.
[Invention 1097]
The oral tobacco product of any of the present invention 1087-1089, wherein the body has a 425N compression ratio of 60% -98%.
[Invention 1098]
The oral tobacco product of any of the present invention 1087-1089, wherein the body has a modulus of elasticity of 75% to 90%.
[Invention 1099]
The oral tobacco product of any of the present invention 1087-1089, further comprising an antioxidant.
[Invention 1100]
The oral tobacco product of the present invention 1099 comprising 0.01% to 5.0% by weight of an antioxidant.
[Invention 1101]
The oral tobacco product of any of the present invention 1087-1089, further comprising a soluble fiber.
[Invention 1102]
The oral tobacco product of this invention 1101 wherein the ratio of soluble fiber to cellulosic fiber is from 1:60 to 60: 1.
[Invention 1103]
The oral product of the invention 1101 wherein the soluble fiber comprises maltodextrin.
[Invention 1104]
Extruding a stable polymer in the mouth with tobacco fibers dispersed therein; and
Cutting the extruded mouth-stable polymer and tobacco fiber mixture into individual oral tobacco products sized to be at least partially received in the oral cavity of an adult tobacco consumer
A method of forming an oral tobacco product, comprising:
[Invention 1105]
The method of the invention 1104 further comprising adding soluble fiber during the extruding step.
The details of one or more aspects of the subject matter described in this specification are set forth in the accompanying drawings and the detailed description below. Other features, aspects, and advantages of the subject matter will become apparent from the detailed description, drawings, and claims.
Claims (52)
口内で安定なポリマーマトリックス、
該口内で安定なポリマーマトリックスに埋め込まれたセルロース系繊維、および
該ボディが該口腔内に受け入れられ唾液に曝された際に該ボディから放出されるように該口内で安定なポリマーマトリックス中に分散した、ニコチンまたはその誘導体
を含む、オーラル製品。 An oral product comprising a body that is generally acceptable in the oral cavity, the body comprising:
Mouth-stable polymer matrix,
Cellulosic fibers embedded in the mouth-stable polymer matrix, and dispersed in the mouth-stable polymer matrix so that the body is released into the mouth when exposed to the saliva and exposed to saliva Oral products containing nicotine or its derivatives.
ボディが成人消費者の口内に保持された際に放出されるように該添加物が該ボディ中に分散している、請求項1記載のオーラル製品。 Minerals, vitamins, dietary supplements, nutritional supplements, vigorous agents, soothing agents, amino acids, chemsthetic agents, antioxidants, botanicals, tooth whitening agents, therapeutic agents, and their An oral product further comprising an additive selected from the group consisting of a combination,
The oral product of claim 1, wherein the additive is dispersed in the body such that it is released when the body is held in the mouth of an adult consumer.
をさらに含む、請求項1記載のオーラル製品。 2. The oral product of claim 1, further comprising a flavoring dispersed in the body such that the body is released when placed in the mouth of an adult consumer.
該押出し成形する工程の最中または後でニコチンまたはその誘導体を該口内で安定なポリマー内に分散させる工程
を含む、オーラル製品を形成する方法。 Extruding a stable polymer in the mouth with cellulosic fibers dispersed therein, and dispersing nicotine or a derivative thereof in the stable polymer during or after the extruding step A method of forming an oral product, comprising:
該押出し成形する工程の最中または後でニコチンを該口内で安定なポリマー内に分散させる工程、および
該押出し成形された口内で安定なポリマーを切断して個々のオーラル製品を形成する工程
を含む、オーラル製品を形成する方法。 Extruding a stable polymer in the mouth,
Dispersing nicotine into a stable polymer in the mouth during or after the extruding step, and cutting the stable polymer in the extruded mouth to form individual oral products. How to form oral products.
該押出し成形する工程の最中または後でニコチンを該口内で安定なポリマー内に分散させる工程、および
該押出し成形された口内で安定なポリマーを成形して個々のオーラル製品を形成する工程
を含む、オーラル製品を形成する方法。 Extruding a stable polymer in the mouth,
Nicotine is dispersed in the mouth-stable polymer during or after the extruding step, and the stable polymer is formed in the extruded mouth to form individual oral products. How to form oral products.
口内で安定なポリウレタンマトリックス、
該ポリウレタンマトリックスに埋め込まれた可溶性繊維と不溶性繊維との組み合わせであって、可溶性マルトデキストリン繊維と不溶性セルロース系繊維の比が1:60〜60:1である、可溶性繊維と不溶性繊維との組み合わせ、
該ポリウレタンマトリックス内に分散した0.1mg〜6mgのニコチン、
該ポリウレタンマトリックス内に分散した0.01重量％〜1.0重量％の抗酸化剤であって、パルミチン酸アスコルビル、BHT、アスコルビン酸、アスコルビン酸ナトリウム、ビタミンCの誘導体、クエン酸モノステロール、トコフェロール類、没食子酸プロピル、tert-ブチルヒドロキノン（TBHQ）、ブチル化ヒドロキシアニソール（BHA）、ビタミンE、およびそれらの誘導体または組み合わせである、抗酸化剤
を含み、
該オーラル製品が、該オーラル製品を25℃および相対湿度65％で2週間ねかせたのち、ニコチンの0.50％未満がニコチンN-オキシドに転換するように構成されている、オーラル製品。 An oral product comprising a body that is generally acceptable in the oral cavity, the body comprising:
A mouth-stable polyurethane matrix,
A combination of soluble and insoluble fibers embedded in the polyurethane matrix, wherein the ratio of soluble maltodextrin fibers to insoluble cellulosic fibers is from 1:60 to 60: 1;
0.1 mg to 6 mg nicotine dispersed in the polyurethane matrix,
0.01% to 1.0% by weight of an antioxidant dispersed in the polyurethane matrix, ascorbyl palmitate, BHT, ascorbic acid, sodium ascorbate, vitamin C derivative, monosterol citrate, tocopherols, gallic acid An antioxidant, which is propyl, tert-butylhydroquinone (TBHQ), butylated hydroxyanisole (BHA), vitamin E, and derivatives or combinations thereof ,
An oral product wherein the oral product is configured such that less than 0.50% of nicotine is converted to nicotine N-oxide after aging the oral product at 25 ° C. and 65% relative humidity for 2 weeks.
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261588873P | 2012-01-20 | 2012-01-20 | |
| US201261588851P | 2012-01-20 | 2012-01-20 | |
| US201261588904P | 2012-01-20 | 2012-01-20 | |
| US201261588861P | 2012-01-20 | 2012-01-20 | |
| US61/588,904 | 2012-01-20 | ||
| US61/588,873 | 2012-01-20 | ||
| US61/588,851 | 2012-01-20 | ||
| US61/588,861 | 2012-01-20 | ||
| US201261720852P | 2012-10-31 | 2012-10-31 | |
| US61/720,852 | 2012-10-31 | ||
| PCT/US2013/022252 WO2013109961A1 (en) | 2012-01-20 | 2013-01-18 | Oral product |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018089596A Division JP6560788B2 (en) | 2012-01-20 | 2018-05-08 | Oral products |
Publications (3)
| Publication Number | Publication Date |
|---|---|
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| JP2015503931A5 true JP2015503931A5 (en) | 2016-03-03 |
| JP6549844B2 JP6549844B2 (en) | 2019-07-24 |
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| JP2018089596A Active JP6560788B2 (en) | 2012-01-20 | 2018-05-08 | Oral products |
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| JP (2) | JP6549844B2 (en) |
| CN (2) | CN107259634A (en) |
| AU (1) | AU2013204701B2 (en) |
| CA (1) | CA2861995C (en) |
| DK (2) | DK3098258T3 (en) |
| ES (2) | ES2688212T3 (en) |
| HK (2) | HK1204334A1 (en) |
| RU (1) | RU2688520C2 (en) |
| WO (1) | WO2013109961A1 (en) |
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| US9854831B2 (en) | 2012-01-20 | 2018-01-02 | Altria Client Services Llc | Oral product |
| CN102754907B (en) | 2012-01-20 | 2015-06-24 | 奥驰亚客户服务公司 | Oral product |
| CN102754908B (en) | 2012-01-20 | 2015-06-10 | 奥驰亚客户服务公司 | Oral tobacco product |
| CN103039688B (en) | 2012-01-20 | 2016-01-06 | 奥驰亚客户服务公司 | Oral product |
| EP2996501A1 (en) | 2013-05-13 | 2016-03-23 | Altria Client Services LLC | Oral product |
| US11771127B2 (en) | 2013-10-03 | 2023-10-03 | Altria Client Services Llc | Chewable dissolvable nicotine tablet |
| WO2015051306A1 (en) * | 2013-10-03 | 2015-04-09 | Altria Client Services Inc. | Dissolvable chewable tablet |
| CN104997158B (en) * | 2015-05-29 | 2017-01-18 | 湖北中烟工业有限责任公司 | Preparation method and application of spicy tobacco flavor extract product |
| NO343402B1 (en) * | 2017-04-24 | 2019-02-25 | Swedish Match North Europe Ab | A flavoured moist oral pouched nicotine product comprising triglyceride and a method for manufacturing thereof. |
| RU2754412C2 (en) | 2017-04-24 | 2021-09-02 | Свидиш Мэтч Норт Юроп Аб | Flavored wet oral packaged nicotine product containing triglyceride |
| EP3723516A1 (en) | 2017-12-15 | 2020-10-21 | Swedish Match North Europe AB | A flavoured moist oral pouched nicotine product comprising monoglyceride |
| BG67408B1 (en) * | 2019-04-12 | 2022-01-17 | Софарма Ад | Oral drug composition with plant alkaloid for treatment of addictions |
| CN110432535A (en) * | 2019-08-22 | 2019-11-12 | 河南中烟工业有限责任公司 | A kind of buccal cigarette of tobacco extract fermentation preparation |
| GB202006143D0 (en) * | 2020-04-27 | 2020-06-10 | Nonwovenn Ltd | Nonwoven fabric for oral pounched product, and methods of manufacturing a nonwoven fabric |
| WO2023073922A1 (en) * | 2021-10-29 | 2023-05-04 | 日本たばこ産業株式会社 | Oral product containing indigestible dextrin and composition for said product |
| KR20230143417A (en) * | 2022-04-05 | 2023-10-12 | 주식회사 케이티앤지 | Multi smoking material which can be used smoke or smokeless and manufacturing method thereof |
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-
2013
- 2013-01-18 RU RU2014134071A patent/RU2688520C2/en active
- 2013-01-18 EP EP16178530.8A patent/EP3098258B1/en not_active Revoked
- 2013-01-18 DK DK16178530.8T patent/DK3098258T3/en active
- 2013-01-18 JP JP2014553478A patent/JP6549844B2/en active Active
- 2013-01-18 AU AU2013204701A patent/AU2013204701B2/en active Active
- 2013-01-18 EP EP18185575.0A patent/EP3444297B1/en active Active
- 2013-01-18 CN CN201710270107.1A patent/CN107259634A/en active Pending
- 2013-01-18 CN CN201380014374.2A patent/CN104169346A/en active Pending
- 2013-01-18 EP EP21208338.0A patent/EP4001355A1/en active Pending
- 2013-01-18 WO PCT/US2013/022252 patent/WO2013109961A1/en active Application Filing
- 2013-01-18 ES ES16178530.8T patent/ES2688212T3/en active Active
- 2013-01-18 ES ES13702700.9T patent/ES2592427T3/en active Active
- 2013-01-18 DK DK13702700.9T patent/DK2804897T3/en active
- 2013-01-18 CA CA2861995A patent/CA2861995C/en active Active
- 2013-01-18 EP EP13702700.9A patent/EP2804897B1/en not_active Revoked
-
2015
- 2015-05-26 HK HK15104950.3A patent/HK1204334A1/en unknown
-
2018
- 2018-04-19 HK HK18105127.5A patent/HK1245590A1/en unknown
- 2018-05-08 JP JP2018089596A patent/JP6560788B2/en active Active
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