JP2015500246A5 - - Google Patents
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- Publication number
- JP2015500246A5 JP2015500246A5 JP2014545037A JP2014545037A JP2015500246A5 JP 2015500246 A5 JP2015500246 A5 JP 2015500246A5 JP 2014545037 A JP2014545037 A JP 2014545037A JP 2014545037 A JP2014545037 A JP 2014545037A JP 2015500246 A5 JP2015500246 A5 JP 2015500246A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- metal
- alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 14
- 229910052751 metal Inorganic materials 0.000 claims 12
- 239000002184 metal Substances 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000003446 ligand Substances 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 5
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 239000013522 chelant Substances 0.000 claims 4
- 150000004696 coordination complex Chemical class 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 229910021645 metal ion Inorganic materials 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 229910052697 platinum Inorganic materials 0.000 claims 4
- 229910052793 cadmium Inorganic materials 0.000 claims 3
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 2
- 229910052688 Gadolinium Inorganic materials 0.000 claims 2
- DPOPAJRDYZGTIR-UHFFFAOYSA-N Tetrazine Chemical compound C1=CN=NN=N1 DPOPAJRDYZGTIR-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 150000001345 alkine derivatives Chemical class 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 229910052733 gallium Inorganic materials 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 229910052738 indium Inorganic materials 0.000 claims 2
- 229910052741 iridium Inorganic materials 0.000 claims 2
- 150000002527 isonitriles Chemical class 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 229910052749 magnesium Inorganic materials 0.000 claims 2
- 239000011777 magnesium Substances 0.000 claims 2
- 229910052748 manganese Inorganic materials 0.000 claims 2
- 229910052753 mercury Inorganic materials 0.000 claims 2
- 150000002739 metals Chemical class 0.000 claims 2
- 229910052759 nickel Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052763 palladium Inorganic materials 0.000 claims 2
- 229910052702 rhenium Inorganic materials 0.000 claims 2
- 229910052707 ruthenium Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 229910052719 titanium Inorganic materials 0.000 claims 2
- 229910052721 tungsten Inorganic materials 0.000 claims 2
- 229910052720 vanadium Inorganic materials 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 0 CCNC(NC(CNC)(CNC)CN*NCC(CNC)(CNC)NC(NCC)=S)=S Chemical compound CCNC(NC(CNC)(CNC)CN*NCC(CNC)(CNC)NC(NCC)=S)=S 0.000 description 3
- OBEXNNIMCGHKJP-UHFFFAOYSA-N CC(CNC)(CNC)CNCCNCC(CNC)(CNC)NC(NCCCN(C(C=C1)=O)C1=O)=S Chemical compound CC(CNC)(CNC)CNCCNCC(CNC)(CNC)NC(NCCCN(C(C=C1)=O)C1=O)=S OBEXNNIMCGHKJP-UHFFFAOYSA-N 0.000 description 1
- BRGLHVKKBQEIME-UHFFFAOYSA-N CC(NC(CNC)(CNC)CNCCNCC(CNC)(CNC)NC(NCCCN(C(C=C1)=O)C1=O)=S)=O Chemical compound CC(NC(CNC)(CNC)CNCCNCC(CNC)(CNC)NC(NCCCN(C(C=C1)=O)C1=O)=S)=O BRGLHVKKBQEIME-UHFFFAOYSA-N 0.000 description 1
- BGRJGXSUWPAUPI-UHFFFAOYSA-N CNCC(CNC)(CNCCNCC(CNC)(CNC)NC(NCCCCN=C=S)=S)NC(NCCCCN=C=S)=S Chemical compound CNCC(CNC)(CNCCNCC(CNC)(CNC)NC(NCCCCN=C=S)=S)NC(NCCCCN=C=S)=S BGRJGXSUWPAUPI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161567255P | 2011-12-06 | 2011-12-06 | |
| US61/567,255 | 2011-12-06 | ||
| PCT/AU2012/001483 WO2013082655A1 (en) | 2011-12-06 | 2012-12-06 | Functionalisation of cage amine ligands for metallo-radiopharmaceuticals |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500246A JP2015500246A (ja) | 2015-01-05 |
| JP2015500246A5 true JP2015500246A5 (https=) | 2016-01-28 |
| JP6051227B2 JP6051227B2 (ja) | 2016-12-27 |
Family
ID=48573412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014545037A Active JP6051227B2 (ja) | 2011-12-06 | 2012-12-06 | 金属放射性医薬品のためのケージアミン配位子の官能化 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9364570B2 (https=) |
| EP (1) | EP2788354B1 (https=) |
| JP (1) | JP6051227B2 (https=) |
| AU (1) | AU2012350146B2 (https=) |
| DK (1) | DK2788354T3 (https=) |
| ES (1) | ES2617335T3 (https=) |
| PT (1) | PT2788354T (https=) |
| WO (1) | WO2013082655A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2788354B1 (en) | 2011-12-06 | 2016-11-30 | The University Of Melbourne | Functionalisation of cage amine ligands for metallo-radiopharmaceuticals |
| WO2013181697A1 (en) * | 2012-06-05 | 2013-12-12 | The University Of Melbourne | Bicyclo[6.1.0]non-4-yne compounds suitable for use as linkers in biological applications |
| US9422286B2 (en) | 2014-01-27 | 2016-08-23 | Washington University | Metal-binding bifunctional compounds as diagnostic agents for Alzheimer's disease |
| KR102368068B1 (ko) | 2015-08-24 | 2022-02-25 | 삼성전자주식회사 | 반도체 소자 제조용 조성물 및 이를 이용하는 반도체 소자의 제조 방법 |
| US20230031576A1 (en) * | 2019-11-08 | 2023-02-02 | The University Of Queensland | Radiolabelled targeting ligands |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2370447B1 (en) | 2008-12-02 | 2016-07-27 | The University of Melbourne | Nitrogen-containing macrocyclic conjugates as radiopharmaceuticals |
| EP2788354B1 (en) | 2011-12-06 | 2016-11-30 | The University Of Melbourne | Functionalisation of cage amine ligands for metallo-radiopharmaceuticals |
-
2012
- 2012-12-06 EP EP12856248.5A patent/EP2788354B1/en active Active
- 2012-12-06 WO PCT/AU2012/001483 patent/WO2013082655A1/en not_active Ceased
- 2012-12-06 ES ES12856248.5T patent/ES2617335T3/es active Active
- 2012-12-06 US US14/363,242 patent/US9364570B2/en active Active
- 2012-12-06 JP JP2014545037A patent/JP6051227B2/ja active Active
- 2012-12-06 PT PT128562485T patent/PT2788354T/pt unknown
- 2012-12-06 AU AU2012350146A patent/AU2012350146B2/en active Active
- 2012-12-06 DK DK12856248.5T patent/DK2788354T3/en active
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