JP2015186504A - Calibration system of ultrasonic obturator detection device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a calibration system of an ultrasonic obturator detection device which can efficiently perform evaluation and calibration of an ultrasonic obturator detection device and improve accuracy in detection of a fine obturator.SOLUTION: A calibration system of an ultrasonic obturator detection device comprises: pseudo blood 109 in which pseudo blood cells and pseudo obturators are dispersed in a liquid; a reservoir tank 103 which stores the pseudo blood and drains the pseudo blood from the bottom formed in a funnel shape; a liquid feeding pump 101 which delivers the pseudo blood; pseudo blood vessels 110, 112 which form circulation holes in which the pseudo blood circulates by penetrating material having an acoustic property similar to a living body; and liquid feeding tubes 102, 106, 107 which connect the liquid feeding pump, the reservoir tank and the pseudo blood vessels, and circulate the pseudo blood, and performs calibration of ultrasonic obturator detection devices 1r, 1 by attaching to the pseudo blood vessels ultrasonic probes 2r, 2 of the ultrasonic obturator detection devices 1r, 1 for detecting obturators in the blood with ultrasonic waves.

Description

  The present invention evaluates and calibrates an ultrasonic obturator detection device for irradiating a living body with ultrasonic waves to monitor a blood flow in a blood vessel and detect a micro plug that flows with blood. For a calibration system.

  It is known that there is a strong correlation between the risk of developing thromboembolism such as cerebral infarction and the frequency of detection of microemboli that flow in blood vessels (thrombus causing embolism and microparticles with the same composition). Yes. That is, if a microemboli flowing in a blood vessel can be detected, it can be applied to preventive medicine such as cerebral infarction. At present, the detection of microemboli associated with cerebral infarction is performed by the transcranial ultrasonic Doppler method. As an ultrasonic device using the transcranial ultrasonic Doppler method, there is one as described in Patent Document 1 below. Patent Document 1 describes an ultrasonic device that irradiates blood vessels in the brain via a skull to monitor blood flow and enhance the thrombolytic effect.

  Patent Document 2 listed below describes a pulse Doppler ultrasound system and a related method for monitoring blood flow. In this system and method, a depth mode display and a spectrogram display are simultaneously displayed as a display unit. This system and method uses a hard ultrasonic probe and displays the position and direction of blood flow in multiple colors on a display. In addition, it is also described that the blood flow is monitored by irradiating blood vessels in the brain via the skull with such a system.

  The transcranial ultrasonic Doppler method focuses on the middle cerebral artery, irradiates ultrasonic waves, and processes the Doppler signal waveform to extract and count the characteristics of microemboli in the bloodstream. Has been done. In this way, it is possible to detect the micro plug that flows in the blood vessel by the ultrasonic device. As an ultrasonic device that can be used for detecting a microplug, a plurality of types of devices have already been manufactured and sold.

  Monitoring the blood flow in the blood vessel with the ultrasonic device as described above has been performed to detect the presence of microemboli in the blood flow. However, there is no system for evaluating the detection capability and detection accuracy of such an ultrasonic device, and it is difficult to evaluate and calibrate the ultrasonic plug detection device as a measurement device. Measurement work requiring a long time was required.

JP 2004-154205 A Special Table 2002-529134

  As described above, the presence of microemboli in the bloodstream has been detected by an ultrasonic device, but a system for evaluating and calibrating such an ultrasonic obturator detection device as a measurement device is available. It did not exist, and evaluation and calibration of the ultrasonic obturator detection device could not be performed efficiently. To evaluate and calibrate these ultrasonic obturator detection devices, perform measurements using the ultrasonic obturator detection device to be evaluated, and compare the measurement results with the measurement results of a standard ultrasonic obturator detection device. Such a difficult and time-consuming measurement work is required.

  Therefore, the present invention can efficiently evaluate and calibrate the ultrasonic obturator detection device, and thus can improve the detection accuracy of the micro obturator of the ultrasonic obturator detection device. The present invention relates to an apparatus calibration system.

  In order to achieve the above object, a calibration system for an ultrasonic obturator detection device according to the present invention stores pseudo blood in which pseudo blood cells and pseudo obturators are dispersed in a liquid, and stores the pseudo blood to form a funnel shape. A reservoir tank that allows the simulated blood to flow out from the bottom, a liquid-feeding pump that delivers the simulated blood, and a pseudo-blood vessel that has a flow hole through which the simulated blood flows through a material having acoustic characteristics similar to those of a living body An ultrasonic obturator detection device for detecting an obturator in the bloodstream using ultrasonic waves, and a liquid supply tube for connecting the liquid pump, the reservoir tank and the pseudo blood vessel and circulating the pseudo blood. An ultrasonic probe is attached to the pseudo blood vessel to calibrate the ultrasonic obturator detection device.

  In the calibration system for an ultrasonic obturator detection device, the pseudo blood vessel is preferably a plurality of pseudo blood vessels connected in series.

  Moreover, in the calibration system for the ultrasonic obturator detection apparatus, the pseudo blood vessel may be formed by connecting two pseudo blood vessels in series.

  In the calibration system of the ultrasonic obturator detection device, the pseudo obturator dispersed in the pseudo blood is preferably particles made of gel-like polyacrylamide.

  In the calibration system for the ultrasonic obturator detection device, the pseudo obturator is preferably a particle having a diameter of 90 to 180 μm at the time of water absorption.

  In the calibration system for the ultrasonic obturator detection apparatus, it is preferable that the ultrasonic obturator detection apparatus further includes a heating unit that is installed in the reservoir tank and that heats the pseudo blood so as to have a substantially constant temperature.

  Since this invention is comprised as mentioned above, there exist the following effects.

  Using the calibration system of the present invention, evaluation and calibration of the detection performance of the target ultrasonic obturator detection device can be performed very efficiently as compared to a standard ultrasonic obturator detection device. Efficient and efficient evaluation and calibration of simulated blood circulating in the same state because the detection results of the target ultrasonic obturator detector and standard ultrasonic obturator detector can be directly compared. The time required for evaluation and calibration can be greatly shortened. Furthermore, the detection accuracy of the micro obturator can be improved by improving the apparatus while evaluating the ultrasonic obturator detection apparatus using the calibration system of the present invention.

FIG. 1 is a diagram showing an overall configuration of a calibration system 100 of the present invention. FIG. 2 is a diagram illustrating a configuration of the liquid feeding unit of the liquid feeding pump 101.

  Embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a diagram showing an overall configuration of a calibration system 100 of the present invention. The calibration system 100 of the present invention is for evaluating and calibrating the ultrasonic obturator detection apparatus 1. Here, the ultrasonic obturator detection device 1 is a device for detecting the presence of microemboli in the bloodstream (microparticles having the same composition as the thrombus causing embolism), and embolism such as cerebral infarction. It is used for preventive diagnosis and early diagnosis.

  The calibration system 100 has a circulation path that circulates pseudo blood 109 that is a substitute for blood to be detected when performing evaluation and calibration. This circulation path includes a liquid feed pump 101, a circulation tube 102, a reservoir tank 103, a liquid supply tube 106, a pseudo blood vessel 110, a connection tube 107, a pseudo blood vessel 112, and a circulation tube 102. In addition, the liquid supply tube in the claims corresponds to the circulation tube 102, the liquid supply tube 106, and the connection tube 107.

  The simulated blood 109 is an aqueous solution in which each component is dissolved so as to have a specific gravity and acoustic characteristics equivalent to blood. In the pseudo blood 109, pseudo blood cells having the same size and acoustic characteristics as actual blood cells and pseudo obturators having the same size and acoustic characteristics as actual micro-emboli are dispersed. . The pseudo blood cell and the pseudo obturator have specific gravity that can be dispersed in the pseudo blood 109 for a long time. These preferably have a specific gravity that is equal to or slightly larger than that of the pseudo blood 109.

  Specifically, polystyrene particles having a diameter of about 30 μm are used as pseudo blood cells, and particles having a diameter of about 90 to 180 μm made of polyacrylamide gel, that is, gel-like polyacrylamide, are used as pseudo plugs. Here, the numerical value of the diameter of the polyacrylamide gel is a numerical value at the time of water absorption.

  The simulated blood 109 is stored in the reservoir tank 103. The reservoir tank 103 is a cylindrical container arranged in the vertical direction, and is made of transparent glass. An upper portion of the reservoir tank 103 is an opening, and the circulation tube 102 is inserted from the opening. The simulated blood 109 that has circulated through the circulation path of the calibration system 100 is returned to the reservoir tank 103 through the circulation tube 102.

  The bottom of the reservoir tank 103 is formed in a funnel shape, and the pseudo blood 109 flows out from the central part of the conical bottom whose upper part is wide and the lower part is narrow, and is supplied to the circulation path. Thus, since the bottom of the reservoir tank 103 is formed in a funnel shape, the pseudo blood cells and pseudo obturator particles in the pseudo blood 109 are less likely to settle and stay. The pseudo blood cells and pseudo obturators are circulated in a state of being dispersed in the pseudo blood 109 without almost all staying.

  The reservoir tank 103 is formed long in the vertical direction, and bubbles in the pseudo blood 109 are separated and floated and removed while the pseudo blood 109 is stored in the reservoir tank 103. In addition, a heater 104 is installed in the reservoir tank 103 to keep the temperature of the pseudo blood 109 at a constant value. A temperature sensor is incorporated in the heater 104, and the temperature of the simulated blood 109 can be maintained at a constant value by the temperature control device 105. The temperature of the simulated blood 109 can be set by the temperature control device 105. By maintaining the temperature of the pseudo blood 109 at a constant value, it is possible to prevent the generation of bubbles accompanying changes in the outside air temperature and the pseudo blood temperature.

  The pseudo blood 109 supplied to the circulation path from the reservoir tank 103 is liquid-driven in the direction of the arrow in the circulation tube 102 by the liquid-feed pump 101. The liquid feed pump 101 is a pump that is driven to feed liquid by a rotating roller, and details thereof will be described later. The pseudo blood 109 driven and circulated by the liquid feeding pump 101 is returned to the reservoir tank 103 again through the circulation tube 102.

  One end of the liquid supply tube 106 is connected to the tip of the funnel-shaped outlet of the reservoir tank 103, and the other end of the liquid supply tube 106 is connected to the inflow side connection portion of the pseudo blood vessel 110. The liquid supply tube 106 is preferably a tube made of flexible rubber. This is because the tip of the outlet of the reservoir tank 103 is a thin glass tube and has low strength, so that a large external force is not applied to the tip of the outlet.

  The pseudo blood vessel 110 is formed by forming a through-hole corresponding to a blood vessel in a box-shaped solid body made of a resin having acoustic characteristics equivalent to those of a living body. Connection portions are provided at both ends of the through hole. A pedestal 111 for installing the ultrasonic probe is provided on the upper surface of the pseudo blood vessel 110. The pseudo blood vessel 112 has the same configuration as the pseudo blood vessel 110, and a base 113 for an ultrasonic probe is provided on the upper surface of the pseudo blood vessel 112.

  The pseudo blood vessel 110 and the pseudo blood vessel 112 are connected in series by the connection tube 107, and the circulation tube 102 is connected to the outflow side connection portion of the pseudo blood vessel 112. The liquid supply pump 101, the circulation tube 102, the reservoir tank 103, the liquid supply tube 106, the pseudo blood vessel 110, the connection tube 107, the pseudo blood vessel 112, and the circulation tube 102 constitute a circulation path of the calibration system 100.

  FIG. 2 is a diagram illustrating a configuration of the liquid feeding unit of the liquid feeding pump 101. The circulation tube 102 is disposed on the mounting table 122. The mounting table 122 is formed with a recess having a substantially arc-shaped cross section, and the circulation tube 102 is disposed along the recess. A rotating body 120 driven by an electric motor or the like is disposed above the mounting table 122, and a plurality of (here, four) rollers 121 are provided in the vicinity of the outer periphery of the rotating body 120 so as to be freely rotatable. Yes. When the circulation tube 102 is crushed by the roller 121 and the rotator 120 is rotationally driven as indicated by an arrow, a driving force is applied to the simulated blood in the circulation tube 102, and the simulated blood is moved as indicated by the arrow.

  Due to the configuration of the liquid feed pump 101, a predetermined pulsation component appears in the flow rate of the pseudo blood. This pulsating component corresponds to the pulsating component caused by the heartbeat in the living body, and is very similar to the blood flow in the actual living body. Further, the flow rate of the pseudo blood can be changed depending on the rotation speed of the rotating body 120. The rotational speed of the rotating body 120 can be set to an arbitrary value. Since the circulation tube 102 is deformed by an external force acting periodically, a material excellent in strength and durability is preferable. Specifically, a fluororubber material can be used.

  In such a calibration system 100, as shown in FIG. 1, the ultrasonic obturator detection device 1r and the ultrasonic obturator detection device 1 are attached to the pseudo blood vessels 110 and 112 for evaluation and calibration. Here, the ultrasonic obturator detection device 1r is a standard device whose detection performance has been confirmed in advance, and the ultrasonic obturator detection device 1 is a device to be evaluated and calibrated.

  Here, the ultrasonic obturator detection device 1r has an ultrasonic probe 2r, irradiates ultrasonic waves from the ultrasonic probe 2r toward the inside of the inspection object, and is reflected by the internal structure and blood flow of the inspection object. Detect ultrasound. The ultrasonic obturator detection device 1r performs Doppler signal processing from the transmission / reception signal, and detects microembolts in blood. The ultrasonic obturator detection device 1 is also the same and has an ultrasonic probe 2.

  The ultrasonic probe 2r of the ultrasonic obturator detection device 1r is installed on the base 111 of the pseudo blood vessel 110, and the ultrasonic probe 2 of the ultrasonic obturator detection device 1 is installed on the base 113 of the pseudo blood vessel 112. Since the pseudo blood vessels 110 and 112 are connected in series, pseudo blood in exactly the same state circulates inside each. Therefore, the detection results of the ultrasonic obturator detection apparatus 1 and the ultrasonic obturator detection apparatus 1r can be directly compared with the simulated blood flow in the same state.

  Further, in the calibration system 100, the concentration of the pseudo obturator in the pseudo blood 109 is appropriately changed by adding pseudo obturator particles to the pseudo blood 109 in the reservoir tank 103 or exchanging the pseudo blood 109. Can do. Further, the set concentration of the pseudo obturator can be stably maintained, and the pseudo blood 109 in which the pseudo obturator having a constant concentration is dispersed for a long time can be flowed stably.

  In this way, using the calibration system 100 of the present invention, evaluation and calibration of the detection performance of the ultrasonic obturator detection device 1 are performed extremely efficiently compared to the standard ultrasonic obturator detection device 1r. can do. Since the detection results of the ultrasonic obturator detection device 1 and the ultrasonic obturator detection device 1r can be directly compared with the simulated blood circulating in the same state, the evaluation and calibration can be performed efficiently and efficiently. Therefore, the time required for evaluation / calibration can be greatly shortened. Furthermore, the detection accuracy of the micro obturator can be improved by improving the apparatus while evaluating the ultrasonic obturator detection apparatus using the calibration system of the present invention.

  In the embodiment described above, the calibration system includes two pseudo blood vessels connected in series. However, the number of pseudo blood vessels is not limited to two. The calibration system of the present invention may include three or more pseudo blood vessels connected in series. As the number of pseudo blood vessels increases, the number of ultrasonic obturator detection devices that can be measured simultaneously increases.

  Further, the calibration system of the present invention may include only one pseudo blood vessel. When there is one pseudo blood vessel, it is necessary to perform the measurement by the standard ultrasonic obturator detection device and the measurement by the ultrasonic obturator detection device to be evaluated separately in time rather than simultaneously. For this reason, when the number of pseudo blood vessels is one, the work efficiency of evaluation / calibration is lowered. Therefore, it is preferable to include a plurality of pseudo blood vessels.

  With the calibration system of the present invention, the evaluation performance and calibration of the detection performance of the ultrasonic obturator detection device can be performed very efficiently. Moreover, the detection accuracy of a micro plug can also be improved by improving the apparatus using the calibration system of the present invention.

DESCRIPTION OF SYMBOLS 1,1r ultrasonic obturator detection apparatus 2,2r ultrasonic probe 100 Calibration system 101 Liquid feed pump 102 Circulation tube 103 Reservoir tank 104 Heater 105 Temperature control apparatus 106 Liquid supply tube 107 Connection tube 109 Pseudo blood 110,112 Pseudo blood vessel 111,113 Base 120 Rotating body 121 Roller 122 Mounting table

Claims (6)

Pseudo blood (109) in which pseudo blood cells and pseudo obturators are dispersed in a liquid;
A reservoir tank (103) for storing the simulated blood and allowing the simulated blood to flow out from a bottom formed in a funnel;
A liquid delivery pump (101) for delivering the simulated blood (109);
A pseudo blood vessel (110, 112) having a circulation hole through which pseudo blood flows through a material having acoustic properties similar to a living body;
A liquid feed tube (102, 106, 107) for connecting the liquid feed pump (101), the reservoir tank (103) and the pseudo blood vessel (110, 112) and circulating the pseudo blood (109);
An ultrasonic probe (2r, 2) of an ultrasonic plug detection device (1r, 1) for detecting an plug in the bloodstream by ultrasonic waves is attached to the pseudo blood vessel (110, 112), and the ultrasonic plug A calibration system for an ultrasonic obturator detection device for calibrating the detection device. A calibration system for an ultrasonic obturator detection device according to claim 1,
The pseudo blood vessel (110, 112) is a calibration system for an ultrasonic obturator detection device in which a plurality of pseudo blood vessels (110, 112) are connected in series. The ultrasonic obturator detection device calibration system according to claim 2,
The pseudo blood vessel (110, 112) is a calibration system for an ultrasonic obturator detection device in which two pseudo blood vessels (110, 112) are connected in series. The ultrasonic obturator detection device calibration system according to any one of claims 1 to 3,
The ultrasonic obturator detection device calibration system, wherein the pseudo obturator dispersed in the pseudo blood (109) is particles made of gel polyacrylamide. The ultrasonic obturator detection device calibration system according to claim 4,
The pseudo obturator is a calibration system for an ultrasonic obturator detection device, which is a particle having a diameter of 90 to 180 μm when water is absorbed. It is a calibration system of the ultrasonic obturator detection device according to any one of claims 1 to 5,
A calibration system for an ultrasonic obturator detection device, which is installed in the reservoir tank (103) and has heating means (104) for heating the simulated blood (109) to a substantially constant temperature.

Images