JP2015177916A - monitoring device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a monitoring device for collecting and inspecting a prescribed substance contained in a body fluid without puncture.SOLUTION: A monitoring device 1 comprises: a sampling part 10 for sampling a prescribed substance contained in a body fluid from an organism B; and an inspection part 20 for inspecting the prescribed substance sampled by the sampling part 10. The sampling part 10 executes a cycle multiple times, which includes: a first period during which electric current flows in a first direction in which the prescribed substance is captured by a first electrolyte gel G1; a second period during which no electric current flows; and a third period during which the electric current flows in a second direction that is the opposite direction of the first direction so that at least a portion of the prescribed substance captured by the first electrolyte gel G1 is returned to the organism B. The inspection part 20 inspects the prescribed substance captured by the first electrolyte gel G1 in the first period.

Description

  The present invention relates to a monitoring device, and more particularly to a monitoring device that collects and examines a predetermined substance contained in a body fluid from a living body.

  A diabetic needs to continuously monitor blood glucose levels by collecting blood himself and measuring blood glucose multiple times a day. In such a monitoring method, blood is collected by puncturing a fingertip or the like with a dedicated instrument, and the blood glucose level of the blood is measured with a blood glucose meter. Therefore, not only is there resistance to blood collection, but there is also a risk of infection and the skin of the fingertips becomes hard.

  In recent years, in order to replace this, blood glucose measuring devices capable of continuously measuring blood glucose levels without puncturing many times have been developed, and products of several companies have been put into practical use. In these cases, a patch with a needle-type sensor attached to the back is affixed to the abdomen, and the measurement result of the sensor embedded in the skin is wirelessly transmitted to a small receiver of a diabetic patient by a transmitter mounted on the patch. is there. Thereby, the patient can monitor his blood glucose level continuously.

  However, a sensor implanted under the skin does not have a long life for various reasons, and therefore needs to be replaced once every 3 to 7 days. At present, the diameter of the needle is about 0.5 mm and the length is about 6 to 13 mm (Non-patent Document 1).

National Institute of Rehabilitation No.31, 2010 “History and current status of blood glucose meter development”

  An object of this invention is to provide the monitoring apparatus which extract | collects and test | inspects the predetermined substance contained in a bodily fluid without puncturing.

  A first aspect of the present invention relates to a monitoring device including a collection unit that collects a predetermined substance contained in a body fluid from a living body and an inspection unit that inspects the predetermined substance collected by the collection unit, and the collection unit Includes a first reservoir that contains a first electrolyte gel that captures the predetermined substance contained in the body fluid, a second reservoir that contains a second electrolyte gel, the first electrolyte gel, the second electrolyte gel, and the A circuit for passing a current through a path including a living body, wherein the circuit includes a first period in which a current flows in a first direction in which the predetermined substance is captured by the first electrolyte gel, and a second period in which no current flows. A cycle including a third period in which a current flows in a second direction opposite to the first direction so that at least a part of the predetermined substance captured by the first electrolyte gel is returned to the living body. Run a plurality of times, the measurement part examines the predetermined substance captured by the first electrolyte gel in the first period.

  According to a second aspect of the present invention, there is provided a monitoring device comprising: a collection unit that collects a predetermined substance contained in a body fluid from a living body; and an inspection unit that inspects the predetermined substance collected by the collection unit. Includes a first reservoir that contains a first electrolyte gel that captures the predetermined substance contained in the body fluid, a second reservoir that contains a second electrolyte gel, the first electrolyte gel, the second electrolyte gel, and the A circuit that causes an alternating current to flow through a path including a living body, wherein the first electrolyte gel includes a fluorescent dye that captures the predetermined substance, and the inspection unit irradiates excitation light to the first electrolyte gel. A first detection unit that detects fluorescence from the fluorescent dye, a second detection unit that detects reflected light from a reference reflection surface that reflects excitation light from the irradiation unit, and detection by the first detection unit Results and , Inspecting said predetermined substance on the basis of the detection result by the second detection unit.

  ADVANTAGE OF THE INVENTION According to this invention, the monitoring apparatus which extract | collects and test | inspects the predetermined substance contained in a bodily fluid without puncturing is provided.

The figure which shows the structure of the monitoring apparatus of one Embodiment of this invention. The disassembled perspective view of the collection part in the monitoring apparatus of one Embodiment of this invention. It is a schematic diagram which shows the structure of the monitoring apparatus of one Embodiment of this invention. The figure which shows the structure of the collection part in the monitoring apparatus of one Embodiment of this invention. The figure which shows the operation example of the monitoring apparatus of one Embodiment of this invention. The figure which shows the structural example of the circuit which sends an electric current through the path | route containing 1st electrolyte gel, 2nd electrolyte gel, and a biological body. The figure which shows the state which sends the electric current of a 1st direction to the path | route containing a 1st electrolyte gel, a 2nd electrolyte gel, and a biological body in the 1st period. The figure which shows the state which sends the electric current of a 2nd direction to the path | route containing a 1st electrolyte gel, a 2nd electrolyte gel, and a biological body in a 2nd period.

  Hereinafter, the present invention will be described through exemplary embodiments thereof with reference to the accompanying drawings.

  FIG. 1 shows the configuration of a monitoring apparatus 1 according to one embodiment of the present invention. The monitoring device 1 includes a collection unit 10 that collects a predetermined substance contained in a body fluid from a living body, and an inspection unit 20 that inspects the predetermined substance collected by the collection unit 10. The inspection unit 20 may have an integral configuration, but in the example illustrated in FIG. 1, the inspection unit 20 is separated from the first part 22 and the first part 22 integrated with the sampling unit 10. Wireless communication is performed between the first portion 22 and the second portion 24. The inspection unit 20 includes a display unit D that displays the inspection result, and the display unit D is typically provided in the second portion 24. The collection unit 10 and the first portion 22 are portions that are attached to the skin of a living body, and can be referred to as patches P.

  FIG. 2 is an exploded perspective view of the collection unit 10. FIG. 3 is a schematic diagram illustrating the configuration of the monitoring device 1. The collection unit 10 collects a predetermined substance (glucose in this example) contained in the body fluid from the living body B by reverse iontophoresis.

  Reverse iontophoresis is a method in which a pair of electrodes are attached to the skin surface of a living body, and an electric current is passed through the pair of electrodes and the living body, thereby inducing ion movement in the living body and taking out a body fluid from the body. Since cells in a living body generally have a negative surface charge, there are a large number of cations between cells (particularly near the cell surface). When the electric field is formed, the positive ions are attracted by the electric field and move toward the negative electrode. At this time, the water moves together, and the neutral molecule glucose moves along with the movement of the water.

  The collection unit 10 includes a first reservoir R1 that houses a first electrolyte gel G1 that captures glucose contained in body fluid, a second reservoir R2 that houses a second electrolyte gel G2, a first electrolyte gel G1, and a second electrolyte. And a circuit CC for passing an electric current through a path including the gel G2 and the living body B. The first electrolyte gel G1 includes a fluorescent dye that captures glucose. By reverse iontophoresis, glucose contained in the body fluid moves into the first electrolyte gel G1. On the other hand, since the fluorescent dye is bonded and fixed to the first electrolyte gel G1, it does not move even if an electric field is formed. Examples of suitable fluorescent dyes are described in the claims of Japanese Patent Application Laid-Open No. 2010-209339.

  The collection unit 10 includes a first electrode EL1 that contacts the first electrolyte gel G1 and a second electrode EL2 that contacts the second electrolyte gel G2. The collection unit 10 may further include an insulating plate INS that covers the first electrode EL1 and the second electrode EL2. A connection part C1 for connecting the first electrode EL1 and the circuit CC and a connection part C2 for connecting the second electrode EL2 and the circuit CC are arranged so as to penetrate the insulating plate INS. The connection part C1 is connected to the circuit CC via the connection line W1, and the connection part C2 is connected to the circuit CC via the connection line W2. The circuit CC is supplied with power by the first power supply PW1, and is controlled by the first control unit CNT1. In this example, the first power supply PW1 and the first control unit CNT1 are provided in common for the sampling unit 10 and the first portion 22 of the inspection unit 20. However, different power sources may be provided for the sampling unit 10 and the first portion 22 of the inspection unit 20, or different control units may be provided.

  As illustrated in FIG. 4, the first electrolyte gel G1 preferably includes an electrolyte gel layer G11 containing a fluorescent dye and an electrolyte gel layer G12 not containing the fluorescent dye. The reason for this is as follows. If the electrolyte gel containing the fluorescent dye is thickened, it is necessary to increase the amount of movement of the body fluid accordingly, so it is not preferable to make the electrolyte gel containing the fluorescent dye too thick. On the other hand, when the electrolyte gel containing the fluorescent dye is thinned, the production becomes difficult and the dispersion of the characteristics of the electrolyte gel increases. For these reasons, the thickness of the electrolyte gel containing the fluorescent dye is preferably about 0.05 mm, for example. However, at this thickness, the volume is small and it is difficult to keep the pH within the appropriate range (reverse iontophoresis requires the pH to be within a certain range), so the amount of solvent necessary to stabilize the pH In order to ensure (for example, salt solution), it is preferable to provide the electrolyte gel layer G12.

  The inspection unit 20 includes an irradiation unit LS that irradiates the first electrolyte gel G1 with excitation light, a detection unit PD1 that detects fluorescence from the fluorescent dye in the first electrolyte gel G1, and a detection unit (first detection unit) PD1. And a processing unit PRC that obtains the concentration of glucose based on the detection result by. The irradiation unit LS can include a light source such as an LED. The detection unit PD1 can include an optical sensor such as a photodiode. Here, when the fluorescent dye in the first electrolyte gel G1 is combined with glucose, it generates fluorescence when receiving excitation light. Therefore, the processing unit PRC can detect the amount of the fluorescent dye combined with glucose, that is, the concentration of glucose, based on the detection result by the detection unit PD1. The first electrode EL1 may be provided with an opening OP for irradiation of excitation light by the irradiation unit LS and capture of fluorescence by the detection unit PD1. Alternatively, the first electrode EL1 can be made of a transparent material.

  In the example shown in FIG. 3, the first portion 22 of the inspection unit 20 includes an irradiation unit LS, a detection unit (first detection unit) PD1, a sensing circuit SC, a communication module CM1, and a power supply PW1. The detection result by the detection unit (first detection unit) PD1 is captured by the sensing circuit SC and converted into digital data, and the communication module CM1 provided in the first part 22 and the communication module CM2 provided in the second part 24. Is transmitted to the control unit CNT2. For example, the processing unit PRC is incorporated in the control unit CNT2 and determines the glucose concentration based on the detection result provided from the detection unit (first detection unit) PD1 via the sensing circuit SC and the communication modules CM1 and CM2. calculate. The control unit CNT2 displays the glucose concentration calculated by the processing unit PRC on the display unit D. An optical filter F may be provided on the detection surface of the detection unit PD1. The optical filter F can be configured to remove wavelength components other than the wavelength components of the fluorescence generated by the fluorescent dye. Thereby, the fluorescence generated by the fluorescent dye can be detected with a high S / N ratio.

  The inspection unit 20 or the first portion 22 may further include a second detection unit PD2 that detects reflected light from the reference reflection surface RRS that reflects excitation light from the irradiation unit LS. The processing unit PRC is configured to obtain the glucose concentration based on the detection result by the second detection unit PRC2 in addition to the detection result by the detection unit PD1. The reference reflecting surface RRS can be configured by at least a part of one surface of the first electrode EL1 and the second electrode EL2. The detection result by the second detection unit PD2 can be used as a reference signal for correcting the influence due to the intensity fluctuation of the excitation light irradiated by the irradiation unit LS.

  The fluorescent dye in the first electrolyte gel G1 may have temperature characteristics. Therefore, it is preferable to provide the temperature sensor TS. The processing unit PRC can correct the detection result by the detection unit PD1 or the glucose concentration calculated based on the detection result based on the detection result by the temperature sensor TS. The detection result by the temperature sensor TS can be provided to the processing unit PRC via the sensing circuit SC and the communication modules CM1 and CM2.

  The temperature sensor TS can be configured to detect the temperature of the first electrolyte gel G1. The temperature sensor TS can be, for example, an infrared temperature sensor. Here, since the temperature of the first electrolyte gel G1 and the temperature of the insulating plate INS can be considered to be substantially equal, the temperature sensor TS uses the temperature of the insulating plate INS instead of the temperature of the first electrolyte gel G1. It may be configured to detect temperature. Here, since the temperature of the first electrolyte gel G1 and the temperature of the second electrolyte gel G2 can be considered to be substantially equal, the temperature sensor TS uses the second electrolyte instead of the temperature of the first electrolyte gel G1. The temperature of the gel G2 may be measured.

  For example, silver / silver chloride electrodes may be employed as the first electrode EL1 and the second electrode EL2. In the case of a silver / silver chloride electrode, since paste-like silver / silver chloride can be printed on polyimide or polyethylene, the first electrode EL1 and the second electrode EL2 can be formed integrally with the insulating plate INS by a method of manufacturing a flexible substrate. it can. The formation of the electrode by printing can form a complicated electrode shape at a low cost, which is advantageous for realizing an electrode shape that can be easily irradiated with excitation light by the irradiation unit LS and easily captured by the detection unit PD1. The first electrode EL1 has a lattice shape or a mesh shape in consideration of the irradiation of excitation light by the irradiation unit LS, the uptake of fluorescence by the detection unit PD1, and the flow of current evenly through the first electrolyte gel G1. Also good.

  FIG. 5 shows an operation example of the monitoring device 1. The circuit CC performs a cycle including the first period, the second period, and the third period over a plurality of times under the control of the control unit CNT1. The first period is a period in which current flows in the first direction in which glucose is captured by the first electrolyte gel G1. Here, the first direction is the direction in which glucose contained in the body fluid of the living body B is captured by the first electrolyte gel G1, that is, the direction in which the cation moves from the living body B toward the first electrolyte gel G1 (the living body B). Direction in which current flows from the first electrolyte gel G1 to the first electrolyte gel G1).

  The second period is a period in which no current flows (period in which the current is stopped). In direct current reverse iontophoresis, when polarization occurs in the skin of the living body B under the first electrode EL1 and the second electrode EL2, and the reverse iontophoresis is repeated at short intervals, the amount of movement of body fluid (interstitial fluid) Irritation occurs and skin irritation occurs, resulting in erythema on the skin. By providing this second period, irritation to the skin is alleviated. In the second period, the inspection unit 20 inspects the glucose captured by the first electrolyte gel G1 in the first period, and measures the glucose concentration.

  Here, the glucose test by the test unit 20 may be performed in the first period in which reverse iontophoresis is performed. The glucose test by the test unit 20 may be performed, for example, immediately before the end of the first period. Alternatively, the first period may be terminated when the measured glucose concentration satisfies a predetermined condition while monitoring (measuring) the glucose concentration at a predetermined frequency during the first period.

  The third period is a period in which current is supplied in a second direction that is opposite to the first direction so that at least a part of the glucose captured by the first electrolyte gel G is returned to the living body B. The second direction is the direction in which glucose captured by the first electrolyte gel G1 returns to the living body B, that is, the direction in which cations move from the first electrolyte gel G1 toward the living body B (from the first electrolyte gel G1 to the living body B). Direction in which current flows in the direction of. Similarly to the first period, when the third period is repeated at short intervals, polarization occurs in the skin of the living body B under the first electrode EL1 and the second electrode EL2, and the amount of movement of body fluid (interstitial fluid) is reduced. As it decreases, irritation to the skin occurs, and erythema may occur in the skin. Therefore, it is desirable to set the time from the end of the third period to the start of the next first period to be longer than the second period.

  FIG. 6 illustrates the configuration of a circuit CC that allows current to flow through a path including the first electrolyte gel G1, the second electrolyte gel G2, and the living body B. The circuit CC operates by receiving the supply of the voltage VPW1 from the first power supply PW1. The circuit CC can include a current source CS and switches SW1, SW2, SW3, SW4. The current source CS can be constituted by, for example, a MOS transistor that operates in a saturation region.

  The switch SW1 and the switch SW4 are controlled to open / close by the first control signal DA1, and the switch SW2 and the switch SW3 are controlled to open / close by the second control signal DA2. Activation and deactivation of the first control signal DA1 and the second control signal DA2 are controlled by the control unit CNT1. The switch SW1 and the switch SW3 are connected in series between the current source CS and the negative potential, and the connection line W2 is connected between the switch SW1 and the switch SW3 (the connection line W2 is connected to the second electrode EL2). Is connected. The switch SW2 and the switch SW4 are connected in series between the current source CS and the negative potential, and the connection line W1 is connected between the switch SW2 and the switch SW4 (the connection line W1 is connected to the first electrode EL1). Is connected.

  In the first period, the control signal DA1 is activated while the control signal DA2 is deactivated, and the switches SW1 and SW4 are turned on while the switches SW2 and SW3 are turned off. As a result, the circuit CC enters the state shown in FIG. 7A, and a current flows in the first direction D1 as shown in FIG. 7B. At this time, glucose contained in the body fluid in the living body B is captured by the first electrolyte gel G1 stored in the first reservoir R1.

  In the third period, the control signal DA2 is activated while the control signal DA1 is deactivated, and the switches SW2 and SW3 are turned on while the switches SW1 and SW4 are turned off. As a result, the circuit CC enters the state shown in FIG. 8A, and current flows in the second direction D2 as shown in FIG. 8B. At this time, glucose captured by the first electrolyte gel G1 accommodated in the first reservoir R1 is returned to the living body B.

  Hereinafter, a specific usage example of the monitoring device 1 will be described. Monitoring is started by wiping the skin of the living body B, applying the patch P of the monitoring device 1, and turning on a monitoring start switch (not shown).

  In the first period, for example, a current flows in the first direction D1 under the following conditions.

Current density: 0.2~0.5mA / cm ² (Standard: 0.25mA / cm ²⁾
Contact area with skin: 0.25 to ⁴ cm ² (standard: 1 cm ² )
Applied voltage: 18Vmax
Energizing time: 5-15 minutes (standard: 10 minutes)
This condition is a condition that causes little damage to the skin and pain during use. By passing an electric current in the first direction D1, interstitial fluid (body fluid) containing glucose moves to the first electrolyte gel G1. For example, the first electrolyte gel G1 is obtained by fixing a boronic acid group-introduced fluorescent dye that binds to a saccharide and exhibits a Stokes shift to a hydrogel.

  The electrolyte gel is irradiated with excitation light from an LED, and the fluorescence intensity at that time is measured by the PD. Note that the current is stopped and no electric field is applied during the period in which the excitation light is irradiated and the fluorescence intensity is measured.

  Next, in the second period, the current is stopped, and inspection is performed by the inspection unit 20. The irradiation unit LS irradiates the first electrolyte gel G1 with excitation light, whereby the fluorescent dye combined with glucose in the first electrolyte gel G1 generates fluorescence. And detection part PD1 detects the fluorescence from the fluorescent dye in 1st electrolyte gel G1. The detection result by the detection unit PD1 is captured by the sensing circuit SC and converted into digital data, and the control unit CNT2 is transmitted via the communication module CM1 provided in the first portion 22 and the communication module CM2 provided in the second portion 24. Sent to. The processing unit PRC calculates the glucose concentration based on the detection result by the detection unit PD1 in the second period, and the control unit CNT2 displays the calculated glucose concentration on the display unit D. When calculating the concentration of glucose, the concentration of glucose can be corrected based on the detection result by the second detection unit PD2 and / or the temperature sensor TS. The second period can be set to the same length as the first period.

  Polarization occurs in the skin of the living body B in the first period, and the amount of movement of the body fluid (interstitial fluid) is reduced and the skin is stimulated. By providing the second period, the skin irritation is alleviated.

  Next, in the third period, a current flows in the second direction D2 under the following conditions.

Current density: 0.2~0.5mA / cm ² (Standard: 0.25mA / cm ²⁾
Contact area with skin: 0.25 to ⁴ cm ² (standard: 1 cm ² )
Applied voltage: 18Vmax
Energizing time: 5-15 minutes (standard: 10 minutes)
By flowing an electric current in the second direction D2, the interstitial fluid (body fluid) containing glucose contained in the first electrolyte gel G1 is returned to the living body B. The third period can be set to the same length as the first period.

  The example in which the cycle executed in the order of the first period, the second period, and the third period is executed a plurality of times has been described above, but the present invention is not limited to this example. When the time between cycles is long, that is, when the time from the end of the third period to the start of the next first period is long, it is included in body fluids such as sweat from the skin under the patch P during that period Glucose accumulates between the skin and the first electrolyte gel G1, or is captured by the first electrolyte gel G1, and the net glucose concentration of the body fluid collected by reverse iontophoresis cannot be measured. In this case, by executing the third period prior to the execution of the first period, glucose that does not depend on the execution of the first period can be returned to the living body B, and the glucose concentration can be measured with higher accuracy. . Similarly, by measuring the glucose concentration prior to the execution of the first period, the glucose concentration in the first electrolyte gel G1 immediately before the execution of the first period can be measured, and this value and the glucose collected in the first period By calculating the difference in the concentration of glucose, it becomes possible to measure the glucose concentration with higher accuracy.

  When replacing the patch P, a new patch P is pasted while the patch P being used is pasted, and an individual difference between the two patches P is obtained by detecting the glucose concentration in both patches P. And correction can be made based on this. In this case, the second portion 22 of the inspection unit 20 is provided with a function of obtaining detection results from the two patches P, processing these, and correcting them.

  Hereinafter, modifications of the above embodiment will be described. Matters not specifically mentioned as modifications can follow the above embodiment. In the modification, the circuit CC is changed so that an alternating current flows through a path including the first electrolyte gel G1, the second electrolyte gel G2, and the living body B. As a result, the interstitial fluid always flows between the electrolyte gel and the intradermal tissue with the skin as a boundary, but the glucose concentration in the first electrolyte gel G1 is in an equilibrium state with a delay from the start of application of the alternating current. To reach. Therefore, the test | inspection part 20 test | inspects, after waiting for the predetermined time when glucose concentration reaches an equilibrium state. The AC frequency is advantageously in the range of 100 Hz to 10 kHz, for example, and typically 1 kHz can be adopted.

  In the case of alternating current, since voltages in both directions are applied, the polarization charge of the skin is discharged in a half cycle, and the movement of the interstitial fluid is performed efficiently. Therefore, the current density can be relatively lowered, and irritation to the skin can be reduced. Moreover, in order to remove the influence of glucose contained in body fluid such as sweat that has come out of the skin under the patch P, the third period may be performed immediately before the alternating current is applied, or the glucose immediately before the alternating current is applied. The concentration may be measured, and the difference between this value and the glucose concentration measured with an alternating current may be calculated.

1: monitoring device, P: patch, 10: sampling unit, 20: inspection unit, 22: first part, 24: second part, CC: circuit, LS: irradiation unit, PD1: detection unit, PD2: second detection Unit, TS: temperature sensor, SC: sensing circuit, CNT1: control unit, CM1: communication module, PW1: power supply, R1: first reservoir, R2: second reservoir, G1: first electrolyte gel, G11: electrolyte gel layer , G12: electrolyte gel layer, G2: second electrolyte gel, first electrode EL1, second electrode EL2, OP: opening, RRS: reference reflecting surface, INS: insulating plate, CM2: communication module, CNT2: control unit, PRC : Processing unit, PW2: Power supply, D: Display

Claims (10)

A monitoring device comprising a collection unit for collecting a predetermined substance contained in a body fluid from a living body, and an inspection unit for inspecting the predetermined substance collected by the collection unit,
The collection unit includes a first reservoir that contains a first electrolyte gel that captures the predetermined substance contained in the body fluid, a second reservoir that contains a second electrolyte gel, the first electrolyte gel, and the second electrolyte. A circuit for passing an electric current through a path including the gel and the living body,
The circuit includes a first period in which current flows in a first direction in which the predetermined substance is captured by the first electrolyte gel, a second period in which current does not flow, and the predetermined substance captured by the first electrolyte gel. A cycle including a third period in which a current is passed in a second direction that is opposite to the first direction so that at least a part of
The inspection unit inspects the predetermined substance captured by the first electrolyte gel in the first period;
A monitoring device characterized by that. The first electrolyte gel includes a fluorescent dye that captures the predetermined substance,
The inspection unit includes an irradiation unit that irradiates the first electrolyte gel with excitation light, a detection unit that detects fluorescence from the fluorescent dye, and the predetermined substance based on a detection result of the detection unit in the second period. A processing unit for determining the concentration of
The monitoring apparatus according to claim 1. The inspection unit further includes a second detection unit that detects reflected light from a reference reflection surface that reflects excitation light from the irradiation unit, and the processing unit includes the second detection result in addition to the detection result by the detection unit. Obtain the concentration of the predetermined substance based on the detection result by the detection unit,
The monitoring apparatus according to claim 2. The circuit includes a first electrode that contacts the first electrolyte gel and a second electrode that contacts the second electrolyte gel;
The reference reflecting surface is constituted by at least a part of one surface of the first electrode and the second electrode.
The monitoring device according to claim 3. The inspection unit includes a first part integrated with the sampling unit and a second part separated from the first part, and wireless communication is performed between the first part and the second part. Made,
The monitoring device according to any one of claims 1 to 4, wherein The inspection unit detects a concentration of the predetermined substance;
The monitoring device according to claim 1, wherein A monitoring device comprising a collection unit for collecting a predetermined substance contained in a body fluid from a living body, and an inspection unit for inspecting the predetermined substance collected by the collection unit,
The collection unit includes a first reservoir that contains a first electrolyte gel that captures the predetermined substance contained in the body fluid, a second reservoir that contains a second electrolyte gel, the first electrolyte gel, and the second electrolyte. A circuit that causes an alternating current to flow through a path including the gel and the living body,
The first electrolyte gel includes a fluorescent dye that captures the predetermined substance,
The inspection unit includes: an irradiation unit that irradiates the first electrolyte gel with excitation light; a first detection unit that detects fluorescence from the fluorescent dye; and a reference reflection surface that reflects excitation light from the irradiation unit. Inspecting the predetermined substance based on a second detection unit that detects reflected light, a detection result by the first detection unit, and a detection result by the second detection unit,
A monitoring device characterized by that. The circuit includes a first electrode that contacts the first electrolyte gel and a second electrode that contacts the second electrolyte gel;
The reference reflecting surface includes at least a part of at least one surface of the first electrode and the second electrode.
The monitoring device according to claim 7. The inspection unit performs wireless communication between the first part integrated with the sampling unit, the second part separated from the first part, and the first part and the second part.
The monitoring device according to claim 7 or 8, wherein The inspection unit detects a concentration of the predetermined substance;
The monitoring device according to any one of claims 7 to 9, wherein