JP2015065935A - Processed eucommia and processed ginger-containing oral composition, and method for enhancing flavor of eucommia - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an oral composition having an enhanced flavor of eucommia.SOLUTION: The oral composition contains a processed eucommia and a processed ginger vegetable. A method for enhancing the flavor of eucommia includes the step of mixing a processed eucommia with a processed ginger vegetable. A method for improving the disintegration of a tablet includes the step of blending a processed eucommia and a processed ginger vegetable.

Description

The present invention relates to an oral composition containing a processed product of licorice and processed ginger plant, a method for enhancing the fragrance of licorice, and a method for improving the disintegration of tablets.

Tochushina Tochu, a deciduous plant native to China, is listed as a herbal medicine in the class of Shinnohonsaku. Currently, Tochu, which is used as a crude drug, is almost native or cultivated in the mainland of China. It cuts an adult tree about 20 years old, peels the bark, and uses the resulting skin as a medicinal product. Used as a raw material. As a medicinal effect of Tochu, the Chinese Medicinal Dictionary and the People's Republic of China's Pharmacopoeia have the effects of “supplementing the liver and kidneys, strengthening the ribs, and soothing the womb. , Residual urine, abnormal bleeding of women, premature abortion, hypertension ", etc., and pinoresinol di-O-β-D-glucoside as a medicinal ingredient And other lignan compounds are reported to be contained. Since such effectiveness is widely known, it is drunk as tea by cooking herbal medicine or roasting leaves. Also known are tablets and capsules containing Tochu as an active ingredient.

Tochu has a unique scent, and oral compositions containing Tochu are required to maintain the scent of Tochu to enhance palatability. However, when blended together with other ingredients to form an oral composition, the scent of Tochu is apt to decay, and there is a problem that a sufficient scent cannot be obtained. In particular, when a tablet is processed with Tochu as an active ingredient, the tablet may be coated in order to avoid quality deterioration due to moisture absorption. However, the problem arises that the scent of Tochu is further impaired by the coating.

Functional foods containing aloe as essential ingredients, those that disclosed Tonaka and ginger as options for innumerable optional ingredients (Patent Document 1), and those that disclosed Tonaka and ginger as options for multiple essential ingredients (Patent Document) 2 and 3) are known. However, the combination of Tochu and ginger is not specifically disclosed, and neither the scent of Tochu nor the disintegration property of the tablet is mentioned.

JP 2001-95529 A JP 2002-275077 A JP-A-6-107556

An object of the present invention is to enhance the scent of Tochu in an oral composition containing Tochu.

The present invention relates to an oral composition containing a processed product of licorice and a processed product of a ginger family plant.

The oral composition is preferably a tablet.

In addition, the present invention relates to a method for enhancing the scent of a licorice, which includes the step of mixing a processed ginger plant product with a licorice processed product.

In addition, the present invention relates to a method for improving the disintegration of a tablet containing a processed product, comprising a step of blending a processed product of a ginger family plant with a processed product.

Since the oral composition of the present invention contains a processed product of a ginger family plant, the scent of Tochu is enhanced. Moreover, since it has not only a processed product of Tochu but also a processed product of a ginger family plant, the disintegration property of a tablet improves.

The oral composition of the present invention contains a processed product of a zhongchu and a processed ginger plant.

The processed products of Tonaka include Eucommia ulmoides oliver (including both coarse and fine powders), extracts obtained by extracting Tochu with a solvent, diluted solutions, concentrated solutions, dried powder, granules Or a paste etc. are included.

The use site of Tochu is not particularly limited and can be appropriately selected. Examples thereof include leaves, bark, fruits, seeds, petiole, xylem, roots, rhizomes and the like. These can be used alone or in combination of two or more. Especially, it is preferable to use a leaf for the reason that the flavor at the time of processing into an oral composition is good.

The pulverized product and extract of Tochu can be produced by the method described in JP-A-2005-289952.

For example, the crushed crushed material can be obtained by drying the collected chuchu leaf and then pulverizing the dried material. In the present invention, drying and pulverization can be performed by any known method. Moreover, the order of a drying process and a grinding | pulverization process is not specifically limited, The frequency | count of both processes is also not specifically limited. Furthermore, both steps can be performed simultaneously. The drying method is not particularly limited, and examples thereof include a method of drying by heating, drying with sunlight, dehumidification drying, and freeze drying. The pulverization process is not particularly limited, and may be dry or wet.

As a processed product of Tochu, there is no particular limitation as long as it is obtained from Tochu, but an active ingredient can be obtained at a higher concentration, so that a Tochu extract and its dry powder are preferable.

When producing a Tochu extract, the Tochu can be used as it is, or pretreatment such as pulverization, cutting, drying and roasting may be performed. The extraction method may be any of immersion, decoction, leaching, reflux extraction, supercritical extraction, ultrasonic extraction, microwave extraction, and the like. As the extraction solvent, either a polar solvent or a nonpolar solvent can be used, and these can also be mixed and used. For example, water; alcohols such as methanol, ethanol, propanol and butanol; polyhydric alcohols such as ethylene glycol, propylene glycol and butylene glycol; ketones such as acetone and methyl ethyl ketone; chain and cyclic ethers such as tetrahydrofuran and diethyl ether Polyethers such as polyethylene glycol; Halogenated hydrocarbons such as dichloromethane, chloroform and carbon tetrachloride; Hydrocarbons such as hexane, cyclohexane and petroleum ether; Aromatic hydrocarbons such as benzene and toluene; Pyridines Supercritical carbon dioxide; oils and waxes, oils such as rapeseed oil, olive oil, soybean oil, and the like. These can be used alone or in combination of two or more, and can be repeated by changing the solvent. . Of these, water and alcohols are preferably used. Examples of water include tap water, purified water, distilled water, and ion exchange water.

For example, when using Tochu leaves, 1-50 parts by weight of solvent is used per 1 part by weight of leaves, and the immersion is performed at 25-100 ° C for 5 minutes to several hours, preferably 30-60 minutes. It is preferable to do this.

The Tochu extract may be a crude product, and the obtained crude product may be appropriately combined with known separation and purification methods to increase their purity. Examples of the purification means include organic solvent precipitation, centrifugation, ultrafiltration, high performance liquid chromatograph, column chromatograph and the like. Although the Tochu extract may be used as it is as a Tochu processed product, it can be made into a dry powder by subjecting it to a drying treatment by a conventionally known method. The drying method is not particularly limited, and examples thereof include spray drying, vacuum concentration drying, and freeze drying. Among these drying methods, the spray drying method is preferable. When drying, an excipient may be added as necessary.

The content of the processed product in the oral composition is not particularly limited, but is preferably 0.01 to 99.9% by weight, more preferably 0, in terms of the content of the processed components in the processed product. 0.01 to 80% by weight, more preferably 0.1 to 70% by weight. If it is less than 0.01% by weight, there is a possibility that the effect produced by the Tochu processed product cannot be sufficiently obtained. In the present specification, the “converting the amount of the ingredients of the Tochu” means the solid content of the ingredients of the Tochu included in the Tochu processed product. For example, when the excipient is contained in the Tochu processed product, It is the value converted excluding the form content.

The ginger plant is a plant belonging to the ginger family (Zingiberaceae), and examples thereof include ginger, myoga, turmeric, hanamyoguga, murasakikijutsu, kyouou, gajutsu, cardamom, hanashukusha, and yakuchi. As the ginger family plant, ginger, myoga and turmeric are preferable, and ginger is more preferable, from the viewpoint that the scent of Tochu can be further enhanced. Examples of the ginger include Kinki Ginger, Sanshu Ginger, Yellow Ginger, and Yanaka Ginger.

Examples of ginger plant use sites include rhizomes, leaves, and flowers, and rhizomes are more preferred because of their good flavor.

Processed ginger plant products include pulverized ginger plants (including both coarse and fine powders), extracts obtained by extracting ginger plants with solvents, diluted solutions, concentrated solutions, dried powder, Granules or pastes are included.

When a ginger plant extract is used as the processed ginger plant product, the ginger plant extract is obtained by, for example, drying or undried product of the rhizome part of ginger plant, organic solvent, water, supercritical fluid or subcritical fluid. It can be obtained by extraction with a solvent. Although the extract may be used as it is as a processed ginger plant product, it can be made into a dry powder by subjecting it to a drying treatment by a conventionally known method. The drying method is not particularly limited, and examples thereof include spray drying, vacuum concentration drying, and freeze drying. When drying, an excipient may be added as necessary.

When using a ginger plant pulverized product as the processed ginger plant product, the ginger plant pulverized product can be obtained by drying the collected ginger plant and then crushing the dried product. In the present invention, drying and pulverization can be performed by any known method. Moreover, the order of a drying process and a grinding | pulverization process is not specifically limited, The frequency | count of both processes is also not specifically limited. Furthermore, both steps can be performed simultaneously. The drying method is not particularly limited, and examples thereof include a method of drying by heating, drying with sunlight, dehumidification drying, and freeze drying. The pulverization process is not particularly limited, and may be dry or wet. The processed raw ginger plant in the present invention is not particularly limited as long as it is obtained from a raw ginger plant, but because it has a good flavor and can effectively enhance the scent of Ginger, it is crushed ginger plant. Is preferred.

The content of the processed ginger plant product in the oral composition is not particularly limited, but is generally 0.005 in terms of ginger plant component amount per total amount of the oral composition from the viewpoint of further enhancing the scent of Tochu. It is 20% by weight, preferably 0.01 to 20% by weight, more preferably 0.1 to 10% by weight, and still more preferably 0.5 to 7% by weight. If it is less than 0.005% by weight, there is a possibility that sufficient disintegration may not be obtained when a tablet is used. If it exceeds 20% by weight, the flavor of ginger increases and the taste tends to deteriorate. In the present specification, the “ginger family plant component amount conversion” is the solid content of the ginger family plant-derived component contained in the ginger family plant processed product, for example, the ginger family plant product contains an excipient. If it is, it is a value converted excluding the excipient content.

The ratio is not particularly limited as long as the processed ginger plant product and the processed sugar product are blended in the oral composition, but the processed ginger plant product is 0.01 to 70 parts per 100 parts by weight of the processed sugar product. Parts by weight are preferred, 0.01 to 50 parts by weight are more preferred, and 0.1 to 20 parts by weight are even more preferred. If the processed ginger plant product is less than 0.01 parts by weight with respect to 100 parts by weight of the processed product, it may not be possible to obtain sufficient disintegration in a tablet. When the processed ginger plant product exceeds 70 parts by weight, the flavor of the ginger increases and the taste tends to deteriorate.

Oral compositions are available in various dosage forms such as tablets, capsules, soft capsules, powders, granules, pills, solutions, emulsions, suspensions, solutions, spirits, syrups, extracts, elixirs. Jelly, powdered beverages and the like. Among these, tablets are preferable.

An oral composition may contain various commonly used ingredients, such as one or more pharmaceutically acceptable excipients, disintegrants, diluents, lubricants, flavors, colorings. Agents, sweeteners, flavoring agents, suspending agents, wetting agents, emulsifying agents, dispersing agents, adjuvants, preservatives, buffering agents, binders, stabilizers, coating agents and the like can be included. In addition, the oral composition can be suitably used for health foods such as supplements that utilize the efficacy of processed food products.

Examples of the excipient include lactose, sucrose, starch, crystalline cellulose, and finely divided silicon oxide. Examples of the disintegrant include starch, agar, and low-substituted hydroxypropylcellulose. Examples of the lubricant include magnesium stearate, calcium stearate, sucrose fatty acid ester, and talc. Examples of the sweetening agent include D-sorbitol, D-mannitol, aspartame, xylitol, sodium saccharin, honey, glucose, reduced maltose syrup, and sucrose. Examples of the binder include hydroxypropyl cellulose, starch, sodium alginate, and povidone.

When a tablet is used as the oral composition, the tablet can be prepared by a method well known in the technical field to which the present invention belongs, for example, a compression molding method using a tableting machine. For tableting, the mixed components may be compressed as they are, or the mixed components may be subjected to a granulation step and the resulting granules may be compressed. In one embodiment, the tablet can be prepared by adding and blending each component according to the formulation, mixing, granulating, drying, sizing and mixing, and tableting the resulting preparation mixture. Moreover, you may make a coated tablet using a coating agent after shaping | molding of a tablet. Examples of the coating agent include shellac, hydroxypropyl cellulose, yeast wrap, and carnauba wax. Examples of the coating method include a method in which a coating agent is sprayed onto a tablet and dried, and a method in which a coating liquid is handled using a sugar-coated bread. The amount of the coating agent is preferably 0.01 to 10% by weight and more preferably 0.1 to 5% by weight with respect to the tablet.

TECHNICAL FIELD The present invention relates to a method for enhancing the scent of Tochu, and a method for improving the disintegration of a tablet containing the Tochu processed product. The method of mixing both is not particularly limited as long as it is possible to uniformly mix the processed product of the tochu and the processed ginger plant with other optional components. The mixing ratio in the oral composition can be applied as it is.

The present invention will be specifically described with reference to examples, but the present invention is not limited to these examples.

(Production Example 1) Tonaka processed product 5 kg of fresh leaves of Tochu were steamed at 110 ° C. for 90 seconds with a zoning steamer for producing Japanese tea. Fresh leaves were put into the machine from the inlet of the zonal steamer, steam was applied from the upper and lower steam supply devices while moving on the conveyor, and steamed at 110 ° C. for 90 seconds. Next, after steaming, the steamed leaves were twisted for 30 minutes using a twisting machine, and then the twisted product was dried at 80 ° C. for 5 hours using a dryer to a moisture content of 5% or less. Thereafter, it was roasted at 110 ° C. for 30 minutes using a fried leaf machine (IR-10SP type: manufactured by Terada Seisakusho). 1 kg of roasted Tochu tea leaves was put into 15 kg of hot water at 90 ° C. and extracted at 90 ° C. for 30 minutes to obtain 14 kg. Thereafter, the mixture was filtered using a 150 mesh filter, and the filtrate was cooled to 5 ° C. and left overnight. The supernatant was taken out, and the filtrate was concentrated at 50 ° C. under reduced pressure to obtain 1 kg. The concentrated solution is processed with a centrifuge manufactured by Kubota Corporation, the precipitate is removed by centrifugation at a rotational speed of 1800 rpm, and the resulting supernatant is sterilized by heating (85 ° C., 2 hours), and extracted with Tochu leaf water I got an extract. The concentrated extract solution was dried by a spray drying method to obtain a tochu leaf extract powder (300 g).

(Examples 1-7 and Comparative Example 1)
The Tonaka processed product obtained in Production Example 1 and the Kinki ginger processed product (Kintoki ginger powder: Koei Kogyo Co., Ltd.) were used and mixed at the ratios shown in Table 1.

(Aroma evaluation)
Five panelists determined the strength of the scent of Tochu in the powder mixture based on the criteria shown below, and the results (average value of five persons) are shown in Table 1.

Determining the strength of the scent of Tochu:
1 No 2 Almost 3 Somewhat 4 Some 5 Strong Note that the improvement rate (%) in Tables 1 to 3 was calculated according to the following formula.
Improvement rate (%) = 100 × strength of each example / strength of corresponding comparative example

The scent of Tochu was enhanced by adding Kinki Ginger to the Tochu processed product. When 0.1 parts by weight or more of Kinki Ginger processed product is added to the processed products, the effect of enhancing the scent of Tochu increases. It was.

(Examples 8 to 15 and Comparative Examples 2 to 3)
The following raw materials were mixed according to the formulations shown in Tables 2 to 3, and after granulation, they were tableted with an impact pressure of 800 kgf. In Examples 8 to 11, tablets were coated by spraying shellac dissolved in alcohol and dried to obtain coated tablets.

(material)
Kintoki Ginger powder: Koei Kogyo Co., Ltd. (Kinoki Ginger rhizome dried and then pulverized into powder)
Reduced maltose: Mitsubishi Corporation Food Tech Co., Ltd.
Crystalline cellulose: Fushimi Pharmaceutical Co., Ltd.
Fine silicon oxide: DSL Japan
Calcium stearate: San Ace Shellac Co., Ltd .: Nippon Shellac Industry Co., Ltd.
Carnavalou: Nippon Wax Co., Ltd.

(Aroma evaluation)
Five panelists determined the strength of the fragrance of Tochu in the tablet in five steps in the same manner as in Examples 1 to 7 and Comparative Example 1, and the results (average values of five persons) are shown in Tables 2-3. .

In contrast to Comparative Examples 2 to 3 containing only the processed product of the licorice as the active ingredient, Examples 8 to 15 containing the processed product of the licorice and the processed ginger plant enhanced the strength of the fragrance of the licorice. In particular, compared with Comparative Example 1 which does not contain a processed ginger plant product, the improvement rate of the scent of the processed product of Example 3 containing the processed ginger plant product was 200%, Compared with comparative example 2 which does not contain a processed ginger family plant, the improvement rate of example 8 containing a processed ginger family plant was 280%. It was found that even when the ratio of the processed product of the ginger family plant to the processed product of the middle class is the same, the effect of enhancing the scent of the processed product of the ginger family product by adding the processed ginger family plant product is particularly enhanced.

In Comparative Example 2 in which the tablets were coated with shellac, the strength of Tochu scent was lower than that of Comparative Example 3, and the strength of Tochu scent was suppressed by the coating. On the other hand, in Examples 8 to 11 containing processed ginger plant products, the scent of Tochu is enhanced to the same level as in Examples 12 to 15 that are not coated, although the tablets are coated. It was.

(Evaluation of disintegration)
The maximum disintegration time of the tablets of Example 9 and Comparative Example 2 was measured according to the Japanese Pharmacopoeia. Specifically, water kept at 37 ± 2 ° C. as a test solution was dispensed into a glass tube of a disintegration tester, six tablet samples were put one by one, and the tester was moved up and down. When the sample was not observed in the glass tube, or even if it was recognized, it was a film or a spongy substance, or the time when the soft substance or the muddy substance became small was regarded as the disintegration time. The measurement results of the maximum disintegration time are shown in Table 4.

The disintegration of the tablet could be improved by the specific combination of the processed product of Tochu and Ginger plant.

(Prescription Examples 1 to 13)
As a result of producing each composition in accordance with a conventional method with the following formulation, the effect of enhancing the fragrance of the processed product of the ginger family plant was confirmed in any composition. Moreover, in the tablet of the prescription examples 1-10, the disintegration improvement was confirmed.

tablet

jelly

Powdered beverage

Soft capsule

Claims (4)

An oral composition containing a processed product of a tochu and a processed product of a ginger family plant. The oral composition according to claim 1, which is a tablet. A method for enhancing the scent of Tochu, comprising the step of mixing the processed product of Ginger family plant with the Tochu processed product. A method for improving the disintegration of a tablet containing a processed product, comprising a step of blending a processed product of a ginger family plant with a processed product.