JP2015017083A - Aerosol for mosquito control and mosquito control method using the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an aerosol for mosquito control which uses an aerosol provided with a quantitative spray function and sustains a control effect against mosquito for 20 h or longer by spraying a specified amount in an indoor space and a mosquito control method using it.SOLUTION: An aerosol for mosquito control comprises (a) metofluthrin as an insect pest control component, (b) an aerosol stock solution containing an organic solvent and (c) a spraying agent, in which an aerosol stock solution/spraying agent vol. ratio is 10-50/50-90 (capacitance ratio) and is provided with an aerosol valve for quantitative spray. The 90% particle size in the volume integration distribution of sprayed particles of the aerosol is 10-80 μm, and an ejection amount of metofluthrin by a single spray operation is 5.0-12 mg per 4.5-8 'jo'(=about 1.6 m). The aerosol for mosquito control makes a treated space controllable against mosquito for 20 h or longer. A method of mosquito control comprises spraying the aerosol for mosquito control quantitatively indoors.

Description

The present invention relates to an aerosol for controlling mosquitoes and a method for controlling mosquitoes using the same.

Aerosol pesticides used indoors include a direct hit type that sprays on target pests such as pests flying in indoor spaces or pests that crawl walls and floors, and the path of pests in advance. There is an ambush type in which aerosol pesticide is sprayed on.

On the other hand, in recent years, as insecticide ingredients with relatively high vapor pressure have been developed, aerosol insecticides containing them are applied in a certain amount in a sealed space in advance, and floating insecticide ingredient particles are left in the air to protect mosquitoes. There are also attempts to prevent control. For example, Patent Document 1 (Japanese Patent Application Laid-Open No. 2001-17055) preferably uses a room-temperature volatile pyrethroid and uses a solvent having a high vapor pressure to reduce the particle size of the treatment agent, thereby increasing the amount of treatment agent. There is described an aerosol insecticide whose residual rate can be 1% or more between 3 hours and less than 12 hours from the start of treatment, or 0.5% or more between 12 hours and less than 24 hours from the start of treatment. Yes. According to Patent Document 1, the smaller the spray particle diameter, the higher the residual ratio of the treatment chemical in the air, and the insecticidal efficacy is maintained. Therefore, the aerosol insecticide that provides such a spray particle diameter is used for flying mosquitoes and the like. It is effective for pest control.
However, in the method of Patent Document 1, there is a limit to the duration of insecticidal efficacy, and it has been recognized that the practical duration is at most 12 to 14 hours.

By the way, the treatment chemical particles sprayed in the air (A) remain floating in the air, (B) adhere to the floor or wall, (C) re-evaporate after B, or (D) light, etc. It is considered to follow any behavior of decomposition and disappearance by. The aerosol insecticide of Patent Document 1 attempts to decrease the ratio (B) of the treatment drug particles and increase the ratio (A).
On the other hand, Patent Document 2 (Japanese Patent Application Laid-Open No. 2001-328913) directly attaches an aerosol containing the insecticidal component metofluthrin to the surface of indoor structures and fixtures, and eliminates flying insects by the action of metfurthrin re-volatilized from the surface. It is disclosed that it can be disinfected. This Patent Document 2 is a method of expecting (C) after (B), but since the transition to (C) is greatly influenced by the use conditions, a stable extermination effect against flying pests is obtained. I can't think of it.

In recent years, there has been a growing demand for aerosols of the above-described quantitative spray type, which have a sustained control effect over about 1 day, ie, over 20 hours, especially over mosquitoes. In view of the present situation, the present inventors first observed the behavior of mosquitoes and, as a result of earnestly examining the mechanism of action of spray drug particles on mosquitoes in a quantitative spray type aerosol, to obtain the following conclusions: It came.
(1) Immediately after spraying, the pests flying to the drug particles floating in the air come into contact with each other, and the controlling effect is exhibited.
(2) Thereafter, with the passage of time, the suspended drug particles adhere to the indoor wall or floor due to dropping or the like.
(3) Mosquitoes such as mosquitoes that have entered from the outside after the spraying process are moored on the walls and floors in the room and are brought into contact with the drugs attached to the mosquitoes.
(4) In the case of flies and flies, compared to mosquitoes, they are more habitable to fly around without being moored to the wall, etc., and because they are relatively less sensitive to drugs, they are in contact with trace particles adhering to walls and floors. In this case, a sufficient control effect cannot be expected.

In this way, in the case of mosquitoes such as mosquitoes, they have the habit of mooring on walls etc. while flying, and because they are highly sensitive to room temperature volatile chemicals such as pyrethroid insecticides, they adhere to walls etc. A sufficient control effect is exhibited by contact with a small amount of drug particles.
Based on the above examination results, the present inventors have started to develop a quantitative spray type aerosol that can maintain a control effect especially for mosquitoes over 20 hours or more. And in the process of studying, it was found that the selection of insecticidal components, spray drug particle size distribution, and the efficiency of drug adhesion to the wall, especially in the room, was extremely important, and as a result of repeating various tests, the present invention was completed. It has come to be.

JP 2001-17055 A JP 2001-328913 A

An object of the present invention is to provide an aerosol for controlling mosquitoes that has a control effect that can be sustained over 20 hours or more by spraying a predetermined amount into an indoor space using an aerosol having a quantitative spray function, and It is to provide a method for controlling mosquitoes using this.

The present invention has been found that the following constitution has an excellent effect for achieving the above-mentioned object.
(1) It consists of an aerosol stock solution containing (a) metofluthrin as a pest control component, and (b) an organic solvent, and (c) a propellant, and the aerosol stock solution / propellant ratio is 10-50 / 50-90 (volume) ) Mosquito control aerosol equipped with an aerosol valve for quantitative spraying,
The aerosol spray particles have a 90% particle diameter of 10 to 80 μm in the volume cumulative distribution, and the amount of methofurin sprayed in one spray process is 5.0 to 12 mg per 4.5 to 8 tatami mats, and its processing space An aerosol for controlling mosquitoes that makes it possible to control mosquitoes for over 20 hours.
(2) The aerosol for mosquito control according to (1), wherein a 90% particle diameter in the volume cumulative distribution of the spray particles is 25 to 70 μm.
(3) The aerosol for mosquito control according to (1) or (2), wherein the organic solvent is a lower alcohol having 2 to 3 carbon atoms and / or a higher fatty acid ester having 16 to 20 carbon atoms in total.
(4) The aerosol for mosquito control according to (3), wherein the lower alcohol having 2 to 3 carbon atoms is ethanol, and the higher fatty acid ester having a total carbon number of 16 to 20 is isopropyl myristate. .
(5) The aerosol for mosquito control according to any one of (1) to (4), wherein an injection force (25 ° C.) at an injection distance of 20 cm is 2.0 g · f or more.
(6) The aerosol for mosquito control according to any one of (1) to (5), wherein a spray volume per time of the aerosol valve for quantitative spraying is 0.1 to 0.9 mL.
(7) A method for controlling mosquitoes, which comprises spraying a predetermined amount of the aerosol for controlling mosquitoes according to any one of (1) to (6) indoors.

The aerosol for controlling mosquitoes of the present invention is extremely practical because the control effect is sustainable for 20 hours or more by spraying a certain amount into the indoor space using an aerosol having a quantitative spray function. Is expensive. The mosquito control method of the present invention, in which a certain amount of this mosquito control aerosol is sprayed indoors, is also very useful.

In the present invention, (a) use of metfurthrin as a pest control component is essential. In Patent Document 1, a room-temperature volatile pyrethroid compound having a vapor pressure at 30 ° C. of 2 × 10 ⁻⁴ to 1 × 10 ⁻² mmHg, for example, transfluthrin, metfurthrin, profluthrin, and empentrin is preferably used in the same row. Flutrin is specifically mentioned as a specific example. However, according to the examination results of the present inventors, when trying to realize an aerosol for controlling mosquitoes that has a sustainable control effect on mosquitoes for 20 hours or more, transfluthrin other than metofluthrin, profluthrin, or empentrin. Was found to be extremely difficult.
This is considered to be related comprehensively to physicochemical properties such as vapor pressure and basic insecticidal activity in each room temperature volatile pyrethroid compound.
The acid component of metofluthrin includes optical isomers and geometric isomers based on asymmetric carbon, and it goes without saying that each of these and arbitrary mixtures are also included in the present invention.

In the mosquito control aerosol and the mosquito control method using the mosquito control aerosol of the present invention, a small amount of methotrelin is sprayed with a high concentration of mosquito control aerosol, so that the methofluthrin content in the aerosol stock solution is 1. The concentration is as high as 0 to 50 w / v%. The organic solvent (b) used in the preparation is appropriately selected in consideration of the compatibility with metofluthrin and the influence on the spray drug particle size distribution. Of these, lower alcohols having 2 to 3 carbon atoms and higher fatty acid esters having 16 to 20 carbon atoms in total are preferred. The former lower alcohol is generally ethanol or isopropanol (IPA), while the latter higher fatty acid ester includes, but is not limited to, isopropyl myristate, butyl myristate, hexyl laurate, and the like. Of these, ethanol and isopropyl myristate are preferred overall.
The desired effect cannot be obtained when the content of metfurthrin in the aerosol stock solution is less than 1.0 w / v%. On the other hand, when the content exceeds 50 w / v%, it is difficult to stabilize the liquid content of the aerosol. Accompany.

The present invention sprays a mosquito control aerosol containing a room temperature volatile pyrethroid compound / metofluthrin indoors in a certain amount, preferably 0.1 to 0.9 mL toward the air at a time. It is characterized by allowing a predetermined amount of the spray particles to adhere to the wall surface while allowing the mosquitoes to be controlled over 20 hours or more while floating and remaining in the air. Here, the predetermined amount of wall surface adhesion is 1% or more with respect to the entire spray particles.
For this reason, the aerosol for mosquito control of the present invention has an aerosol stock solution / propellant ratio of 10 to 50/50 to 90 (volume ratio), and a metfurthrin ejection amount of 4.5 in one spray treatment. It is essential to be 5.0 to 12 mg per 8 tatami mats.
If the aerosol stock solution / propellant ratio is less than 10/90 and there are too many propellants, the spray particles become finer than necessary and the amount of adhesion to the wall is insufficient. On the other hand, when the ratio exceeds 50/50, the spray particles are quickly settled, and the airborne concentration of metfurthrin becomes insufficient.
The injection force (25 ° C.) at an injection distance of 20 cm is preferably 0.5 g · f or more. If it is less than 0.5 g · f, the momentum of spraying is insufficient, and the spray particles do not reach the corner of the room, so a satisfactory mosquito control effect cannot be obtained.
In addition, when the amount of methfluthrin ejected is less than 5.0 mg per 4.5 to 8 tatami mats, the amount adhered to the wall surface is insufficient. On the other hand, even if the amount exceeds 12 mg, the amount adhered to the wall surface does not necessarily correspond to the amount ejected. Economic disadvantages are unavoidable.

In the present invention, unless deviating from the gist of the invention, in addition to metfurthrin, a room temperature volatile pyrethroid compound such as transfluthrin, profluthrin, empentrin, phthalthrin, resmethrin, sifluthrin, phenothrin, permethrin, ciphenothrin, cypermethrin, allethrin. Other pyrethroid compounds such as praretrin, framethrin, imiprothrin, etofenprox, silicon compounds such as silafluophene, organophosphorus compounds such as dichlorvos and fenitrothion, carbamate compounds such as propoxur, etc. .
Further, as the organic solvent, in addition to the lower alcohol having 2 to 3 carbon atoms and the higher fatty acid ester having 16 to 20 carbon atoms in total, for example, hydrocarbon solvents such as n-paraffin and isoparaffin, 3 to 3 carbon atoms, and the like. 6 glycol ethers, ketone solvents and the like can be appropriately added.

Since the aerosol for controlling mosquitoes of the present invention is sufficiently sprayed in a small amount, it is not necessary to pay attention to the danger to fire, but an aqueous formulation can be adopted from the viewpoint of reducing as much as possible. In this case, the amount of water is appropriately about 20 to 70 v / v%, and a small amount of nonionic surfactant is added as a solubilizing aid as long as the spray pattern of spray particles is not hindered. May be.
Examples of the nonionic surfactant include ethers such as polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, polyoxyethylene alkylamino ethers, polyethylene glycol Examples include fatty acid esters, polyoxyethylene sorbitan fatty acid esters, fatty acid esters such as polyoxyethylene glycerin fatty acid esters, polyoxyethylene styrenated phenol, and fatty acid polyalkalol amide, among which ethers are suitable. ing.

In the present invention, in addition to the above-described components, antifungal agents for fungicides, fungi, fungi, antibacterial agents and fungicides, or fragrances, deodorants, stabilizers, antistatic agents, Of course, an antifoaming agent, an excipient and the like may be appropriately blended. Examples of acaricides include methyl 5-chloro-2-trifluoromethanesulfonamide benzoate, phenyl salicylate, 3-iodo-2-propynyl butyl carbamate, and the like. Hinokitiol, 2-mercaptobenzothiazole, 2- (4-thiazolyl) benzimidazole, 5-chloro-2-methyl-4-isothiazolin-3-one, triphorin, 3-methyl-4-isopropylphenol, ortho-phenylphenol, etc. Can be illustrated.
As the fragrance, orange oil, lemon oil, lavender oil, peppermint oil, eucalyptus oil, citronella oil, lime oil, yuzu oil, jasmine oil, coconut oil, green tea essential oil, limonene, α-pinene, linalool, geraniol, Examples include, but are not limited to, aromatic components such as phenylethyl alcohol, amylcinnamic aldehyde, cuminaldehyde, and benzyl acetate, green leaf alcohol called “green scent”, and flavor components containing green leaf aldehyde.

Examples of the propellant (c) used in the present invention include liquefied petroleum gas (LPG) and dimethyl ether (DME), and compressed gas such as nitrogen gas, carbon dioxide gas, nitrous oxide, and compressed air. Two or more types can be employed as appropriate, but those mainly composed of LPG are usually easy to use.
In the present invention, in order to control the treatment space against mosquitoes over 20 hours, the ratio of aerosol solution / propellant is taken into consideration in the air residual rate of spray particles and the adhesion rate to the wall and floor surface. 10 to 50/50 to 90 (capacity ratio). In addition, the 90% particle diameter in the volume cumulative distribution of the spray particles is 10 to 80 μm, preferably 25 to 70 μm, and the amount of methfluthrin jetted in one spray process is 5.0 to 5.0 to 8 to 8 tatami. Designed to be 12 mg.

The above-mentioned mosquito control aerosol is equipped with a fixed-amount aerosol valve for spraying a certain amount indoors, and a suitable spray volume per time is 0.1 to 0.9 mL. The shape of the nozzle, nozzle, container, etc. may be appropriately selected according to the above.
For example, it can be designed as a desktop type equipped with a button to be sprayed from above and an obliquely upward nozzle, or designed for carrying a small container.

According to the present invention, a mosquito control aerosol containing metfurthrin is sprayed indoors at a constant amount, preferably 0.1 to 0.9 mL toward the air at a time, and a predetermined amount of spray particles are suspended in the air. On the other hand, a sufficient amount of spray particles are allowed to adhere to the wall, and the treatment space can be controlled against mosquitoes over 20 hours. It should be noted that the amount of methfluthrin jetted in one spraying process is defined as 5.0 to 12 mg per 4.5 to 8 tatami mats.
On the other hand, since the aerosol insecticide of Patent Document 1 uses transfluthrin as a specific example of flying insect pests, the spray particle size is reduced to increase the residual rate of treatment chemicals in the air. The control duration could not be extended to about 20 hours.

The mosquito control aerosol according to the present invention and the mosquitoes in the mosquito control method using the same include not only common mosquitoes, Culex pipiens, Aedes albopictus etc. It includes things. In other words, as effective pests, in addition to mosquitoes such as Culex pipiens and Aedes albopictus, pests that fly indoors and cause damage or discomfort to humans, such as chironomids, flyfish, butterflies Examples include flying pests to which they belong, but are not limited to these pests.

Next, based on specific examples and test examples, the mosquito control aerosol of the present invention and the mosquito control method using the same will be described in more detail, but the present invention is not limited thereto. Absent.

Methofluthrin was dissolved in ethanol to prepare a 15.0 w / v% aerosol stock solution of metfurthrin. The aerosol stock solution 9 mL and liquefied petroleum gas 21 mL [aerosol stock solution / propellant ratio: 30/70 (volume ratio)] were pressure-filled into an aerosol container with an aerosol valve for quantitative spraying (0.2 mL), and the mosquito of the present invention. An aerosol for controlling insects was obtained.
The spray force (25 ° C.) at a spray distance of 20 cm of this aerosol was 3.7 g · f, and the 90% particle diameter in the volume cumulative distribution of spray particles was 52 μm. In addition, the amount of methfluthrin ejected in one spray treatment was 9.0 mg per 4.5 to 8 tatami mats.

In an almost sealed 6 tatami room, 0.2 mL of the aerosol was sprayed slightly diagonally upward. This aerosol was found to adhere to the wall surface by about 1.8% of the total spray particles after 1 hour of spraying, resulting in bite damage by mosquitoes over 20 hours. It was not very practical. In addition, it was accompanied by a secondary effect of keeping insects such as cockroaches, ants, and beetles away.

According to Example 1, various mosquito control aerosols shown in Table 1 were prepared and subjected to the following tests. The test results are summarized in Table 2.
(1) at the center of 25 m ³ room with fully closed control effect against mosquitoes at room 25 m ³ toward the test aerosol obliquely upward 0.2 mL (however, the present invention 4 0.4 mL) was sprayed . Immediately, 50 female mosquitoes were released and exposed for 2 hours, and then all test mosquitoes were collected. In the meantime, female Culex mosquitoes that fell and turned over time were counted, and the KT ₅₀ value was determined. In the same room, the same operation was performed 10 hours after spraying and 20 hours after spraying.
(2) Metofluthrin ejection amount The metfurthrin ejection amount was calculated from the weight loss before and after the spray treatment.
(3) As a reference for the amount of sprayed wall surface adhering, when calculating the amount of sprayed particle wall surface adhering, 20 × 20 cm glass plates are placed at several locations on the wall surface of a 25 m ³ room, The glass plate was taken out, and the attached pest control components were washed out with acetone and analyzed by gas chromatography. Based on the obtained analysis values, the ratio of the pest control component adhering to the wall surface up to 1 hour after the spraying treatment with respect to the theoretical total amount of spraying was determined.

As a result of the tests according to the present invention 1, comparative example 1 and comparative example 2, although metfurthrin, transfluthrin and profluthrin all correspond to room temperature volatile pyrethroid compounds, this method has a controlling effect on adult mosquitoes for 20 hours or more. Only metfurthrin could be exerted over time. And as an organic solvent which comprises the aerosol stock solution, from contrast with this invention 1-this invention 4 and this invention 6, the C2-C3 lower alcohol and the high-grade total number of carbon numbers are 16-20. Fatty acid esters are preferred, with ethanol and isopropyl myristate being found to be effective. Further, although the 90% particle size in the volume cumulative distribution of spray particles is required to be 10 to 80 μm, the range of 25 to 70 μm is preferable in consideration of the results of the present invention 5 and the present invention 6. It was.
On the other hand, as in the case where the aerosol solution / propellant ratio is out of the range of 10 to 50/50 to 90 (volume ratio) (Comparative Example 3 and Comparative Example 4) and Comparative Example 5, the amount of methfurthrin jetted is 25 m. Those with less than 5.0 mg per ³ rooms (6 tatami mats) did not last until 20 hours.

Methofluthrin was dissolved in isopropyl myristate to prepare a stock solution of 30.0 w / v% methotreline aerosol. This aerosol stock solution 7.0 mL and liquefied petroleum gas 13.0 mL [aerosol stock solution / propellant ratio: 35/65 (volume ratio)] were pressurized and filled into an aerosol container with an aerosol valve for quantitative spraying (0.1 mL), An aerosol for controlling pests according to the present invention was obtained.
The volume-integrated 90% particle size of the aerosol spray particles was 58 μm. In addition, the amount of methfluthrin ejected in one spray treatment was 10.5 mg.

Using the aerosol, 0.1 mL was sprayed slightly obliquely upward in a nearly sealed 6 tatami room. The chironomid was released in this room and the effect was confirmed, but it was immediately knocked down and was not bothered by pests.

Thus, it is clear that the control effect over 20 hours or more can be achieved only by the mosquito control aerosol of the present invention and the mosquito control method using the same.

The present invention can be used not only for mosquitoes but also for the purpose of controlling a wide range of pests.

Claims (7)

(A) Methofluthrin as a pest control component, and (b) an aerosol stock solution containing an organic solvent, and (c) a propellant, wherein the aerosol stock solution / propellant ratio is 10 to 50/50 to 90 (volume ratio). An aerosol for controlling mosquitoes equipped with an aerosol valve for quantitative spraying,
The aerosol spray particles have a 90% particle diameter of 10 to 80 μm in the volume cumulative distribution, and the amount of methofurin sprayed in one spray process is 5.0 to 12 mg per 4.5 to 8 tatami mats, and its processing space For controlling mosquitoes for 20 hours or more. The aerosol for controlling mosquitoes according to claim 1, wherein a 90% particle diameter in a volume integrated distribution of the spray particles is 25 to 70 µm. The aerosol for mosquito control according to claim 1 or 2, wherein the organic solvent is a lower alcohol having 2 to 3 carbon atoms and / or a higher fatty acid ester having 16 to 20 carbon atoms in total. The mosquito control according to claim 3, wherein the lower alcohol having 2 to 3 carbon atoms is ethanol, and the higher fatty acid ester having 16 to 20 carbon atoms in total is isopropyl myristate. For aerosol. The aerosol for mosquito control according to any one of claims 1 to 4, wherein an injection force (25 ° C) at an injection distance of 20 cm is 2.0 g · f or more. The aerosol for mosquito control according to any one of claims 1 to 5, wherein a spray volume per one time of the aerosol valve for quantitative spraying is 0.1 to 0.9 mL. A method for controlling mosquitoes, comprising spraying a fixed amount of the aerosol for controlling mosquitoes according to any one of claims 1 to 6 indoors.