JP2014532701A - Granules with improved dispersion properties - Google Patents

Abstract

Herein, a) providing a powder comprising a pesticidal active ingredient, b) adding water to the powder, c) blending the powder and water into the mixture, and d) mixing the mixture into granules. A method is provided for improving the dispersion characteristics of a pesticide-containing granule in water, including processing, wherein the improvement comprises adding one or more water-soluble aggregation inhibitors to powder or water prior to blending. The amount of the one or more aggregation inhibitors added is required to achieve at least 50% of the saturation concentration in the amount of water added in step (b). Amount.

Description

This application claims priority to US Provisional Patent Application No. 61 / 554,008, filed November 1, 2011, the disclosure of which is hereby incorporated by reference in its entirety. Incorporated herein.

  Provided herein are methods for improving the dispersion characteristics of pesticide-containing granules in water, and compositions of such granules. The described granules exhibit improved dispersibility in water resulting in control of important target pests.

  Agrochemical formulations are generally designed based on customer needs and the physiochemical properties of the active ingredient, such as the solubility of the active ingredient in water or non-aqueous solvents. There are two main categories of formulations: solid formulations and liquid formulations.

  Solid formulations such as granule formulations (GR) and water dispersible granule formulations (WG) containing pesticidal active ingredients are relatively safe compared to liquid formulations, as well as cost savings in packaging and shipping, and organic solvents There is an increase in use today due to the benefits it provides in terms of environmental benefits of eliminating the use of. The WG formulation is designed to disperse easily upon contact with a water carrier in a spray tank and provides performance comparable to an emulsion product. GR formulations are usually designed for spray applications that do not pre-dilute in a carrier such as water. Granule products can be used for the control of insects, weeds, fungal pathogens and nematodes in both water and non-water applications.

  Agricultural granules containing pesticidal active ingredients can also contain inactive ingredients such as solid carriers, surfactants, adjuvants and binders. These inert ingredients include, for example, clay, starch, silica, sulfate, chloride, lignosulfonate, carbohydrates, alkylated cellulose, xanthan gum and guar seed gum, and polyvinyl alcohol, sodium polyacrylate, polyethylene oxide, polyvinyl pyrrolidone. , As well as synthetic polymers such as urea / formaldehyde polymers such as PergoPak® M (registered trademark of Albemarle Corporation). Active ingredients contained in the WG product may include herbicides, insecticides, fungicides, plant growth regulators and safety agents.

  Adjuvants are an important component of formulated agricultural products and are defined as substances that can increase the biological activity of an active ingredient but are not significantly biologically active per se. Adjuvants aid the effectiveness of the active ingredient, for example, by improving the delivery and uptake of herbicides to the target weed plant, resulting in improved biological control.

  Adjuvants can be added to formulated agricultural products such as granules in solid or liquid form, resulting in improved product performance upon application. Commonly used adjuvants can include, for example, surfactants, spreading agents, petroleum and plant derived oils and solvents, and wetting agents. Examples of commonly used adjuvants include, but are not limited to, polyol fatty acid esters, polyethoxy, such as paraffin oil, horticultural spray oil (eg, summer oil), methylated rapeseed oil, methylated soybean oil and highly refined vegetable oil. Ethoxylated esters, ethoxylated alcohols, alkyl polysaccharides and blends, amine ethoxylates, sorbitan fatty acid ester ethoxylates, polyethylene glycol esters, organosilicone surfactants, ethylene vinyl acetate terpolymers, and ethoxylated alkyl aryl phosphate esters Can be mentioned. These and other adjuvants are described in `` Compendium of Herbicide Adjuvants, 9th Edition '' edited by Bryan Young, Dept. of Plant, Soil and Agricultural Systems, Southern Illinois University MC-4415, 1205 Lincoln Drive, Carbondale, IL 62901. Which can be viewed on the Internet at http://www.herbicide-adjuvants.com/.

  The term “built-in adjuvant” refers to one or more adjuvants added to a particular formulation, such as a granular formulation or a liquid formulation, at the stage of manufacture of the product, rather than at the time of use of the product, for example a spray solution. The use of built-in adjuvants simplifies the use of agrochemical products for the end user by reducing the number of components that must be individually measured and applied. However, the loading limit and physiochemical properties of the active ingredient can make it difficult to add adjuvants to the composition. Efforts to prepare pesticide formulations using built-in alkylpolyglucosides among other adjuvants have recently been disclosed, for example in WO2010 / 049070A2 and WO2008 / 066661.

  Described herein are methods for improving the dispersive properties of pesticide-containing granules and compositions of such granules in water. The described granules exhibit improved physical stability and improved dispersibility in water.

In this specification,
a) preparing a powder comprising a pesticidal active ingredient;
b) adding water to the powder;
There is provided a method for improving the dispersion properties of a pesticide-containing granule in water comprising c) blending the powder and water into a mixture, and d) processing the mixture into granules, wherein The improvement method is characterized in that the one or more water-soluble aggregation inhibitors are mixed with the powder or water before blending, and the amount of the one or more aggregation inhibitors added is at least the step This is the amount required to achieve 50% of the saturation concentration in the amount of water added in (b).

Also,
a) about 10 grams per kilogram (gai / kg) to about 900 gai / kg of pesticide active ingredient relative to the total composition;
b) about 20 grams per kilogram (g / kg) to about 900 g / kg per kilogram of total composition, and c) solid anionic surfactant and solid based on total composition About 10 g / kg to about 300 g / kg of at least one nonionic surfactant
Including pesticide-containing granules having improved dispersion properties in water are provided.

  The composition can optionally include one or more additional inert formulation ingredients.

  Also provided are pesticide-containing granules having improved dispersion properties in water, wherein the pesticide is fluroxypyrmeptyl.

  Also, the resulting aqueous solution containing the addition of pesticide-containing granules having improved dispersion properties in water to a carrier such as water and the dispersed pesticide active ingredient for spray application Provides a method for controlling unwanted vegetation, fungal pathogens, bacteria or insects, including controlling unwanted vegetation, fungal pathogens, bacteria or insects in crop or non-crop environments .

DETAILED DESCRIPTION Solid pesticide compositions, such as granules (GR) and water dispersible granules (WG), containing high concentrations of agricultural active ingredients are within the range of temperatures and shear stresses normally encountered during processing and storage. Due to their tendency to physically degrade when exposed to water, production and storage can be difficult. In addition, these compositions may also suffer from poor dispersion in water and poor delivery of active ingredients to sites of pests that require control or elimination.

  Stable granules are generally defined as being physically and chemically stable to the environment in which they are produced and stored and are biologically effective when used within a defined period of time. Deliver acceptable levels.

  Described herein is a method for improving the dispersibility characteristics of pesticide-containing granules and compositions thereof in water. The method involves the use of a novel water-soluble aggregation inhibitor as a component of an aqueous binder solution used in the process of preparing pesticide-containing granules from a powder containing a pesticidal active ingredient. The described granules exhibit improved physical stability and improved dispersibility in water.

  The disclosed methods and compositions provide improved properties for dispersion in water to water-dispersible granules, which are pesticidal active ingredients, water-soluble aggregation inhibitors, solid anionic or nonionic At least one of the surfactants and optionally one or more additional inert formulation ingredients.

  The powder containing the pesticidal active ingredient used in the methods described herein may include a pesticidal active ingredient in powdered form or a suitable composition thereof. Exemplary compositions of pesticide active ingredients include, for example, air milled pesticide active ingredients, spray dried pesticide active ingredients, spray dried microencapsulated pesticides A solid carrier containing the active ingredient or pesticidal active ingredient may be included, each suitable composition optionally containing one or more additional inert ingredients. The pesticidal active ingredient may be in liquid or solid form. Liquid or very low melt pesticide active ingredients can be absorbed onto microencapsulated or solid carriers to form stable water dispersible granules with improved properties for dispersion in water it can. The methods provided herein are particularly processed into stable granules that are either liquid at room temperature or have a low melting point (less than about 100 ° C.) and have acceptable dispersibility in water. Suitable for the preparation of granular formulations containing pesticidal active ingredients, which are usually difficult to do.

  The pesticidal active ingredient for use in the methods and compositions described herein is from one or more of herbicides, insecticides, fungicides, bactericides and herbicide safeners. You can choose. The pesticidal active ingredient is about 10 gai / kg to about 900 gai / kg, in some embodiments about 20 gai / kg to about 850 gai / kg, and in some embodiments about 50 gai, relative to the total composition. / Kg to about 750 gai / kg.

Suitable herbicidal active ingredients and derivatives thereof for use in the methods and compositions described herein include, but are not limited to, 4-CPA, 4-CPB, 4-CPP, 2,4- D, 3,4-DA, 2,4-DB, 3,4-DB, 2,4-DEB, 2,4-DEP, 3,4-DP, 2,4,5-T, 2,4 5-TB, 2,3,6-TBA, alidochlor, acetochlor, acifluorfen, aclonifen, alachlor, alloxidim, allorac, ametridione, amethrin, amivudine, amicarbazone, amidosulfuron, aminocyclopyrchlor, aminopyralide, amiprophos- Methyl, amitrole, anilophos, anisulone, ashram, atraton, atrazine, azaphenidine, azimusulfuron, a Protollin, Baban, BCPC, Befurubutamido, benazolin, Benkarubazon, benfluralin, benfuresate, bensulfuron, bensulide, bentazone, Benzadokusu, benz Fen di Zon, Benjipuramu, benzobicyclon, Benzofenapu, Benzofuruoru, benzoyl prop Benzuchiazuron, Bishikuropiron (bic yl opyrone), bifenox, vilanfos, bispyribac, bromacil, bromobonyl, bromobutide, bromophenoxime, bromoxynil, brompyrazone, butachlor, butaphenacyl, butamifos, butenachlor, butidazole, butyuron, butralin, butroxime, buturon, butyrate, benzoxyl , Carbetamid, carboxazole Lorprocarb, carfentrazone, CDEA, CEPC, chlormethoxyphen, chloramben, chloranoclyl, chlorazihop, chlorazine, chlorbromulone, chlorbufam, chloretulone, chlorfenac, chlorfenprop, chlorflurazole, chlorflurenol, chloridazon, chlorimuron , Chloronitrophene, chloropon, chlorotoluron, chloroxuron, chloroxinyl, chlorpropham, chlorsulfuron, chlortar, chlorthiamid, sinidone-ethyl, cinmethyline, sinosulfurone, cisanilide, cletodim, cryogenate, clodinahop, clohop, cromazone, cloprop, proxy Jim, Clopyralide, Chloranthram, CPMF, CPPC, Redadine, cumyluron, cyanatoline, cyananadine, cycloate, cyclosulfamuron, cycloxidim, cyclulone, cyhalohop, ciperquat, ciprazine, ciprazole, cypromide, diemron, dalapon, dazomet, delachlor, desmedifam, desmethrin, dialate, dicovale, diclobenyl , Dichlorprop, Dichlorprop-P, Diclohop, Diclosram, Dietamquat, Dietachil, Diphenopentene, Diphenoxuron, Difenzocote, Diflufenican, Diflufenzopyr, Dimeflon, Dimepiperate, Dimetachlorine, Dimetamethrin, Dimethenamide, Dimethenamide, Dimethenamide, Dimethenamide Zimidazone, dinitramine, dinophenate, dinopro , Dinosum, dinocebu, dinoteb, diphenamide, dipropetrin, diquat, disulfur, dithiopyr, diuron, DMPA, DNOC, EBEP, eglinazine, endosal, epronaz, EPTC, elbon, esprocarb, ethalfluralin, ethameturflon etiotrithrone fetyl , Ethoxyphene, ethoxysulfuron, ethinophene, etonipromide, ettobenzanito, EXD, phenus lam, phenoprop, fenoxaprop, phenoxaprop-P, phenoxasulfone, fenteracol, fenthiaprop, fentrazamide, phenuron, flamprop, fram Prop-M, Frazasulfuron, Floraslam, Fluazifop, Fluazifop-P, Fluazolate, Lucarbazone, flucetosulfuron, fluchloraline, flufenacet, flufenican, flufenpyr, flumetram, flumedin, full microrack, flumioxazin, flumipropine, fluometuron, fluorodiphen, fluoroglycophene, fluoromidine, fluoronitrophene, fluothiuron, flupoxam, flupropacil , Flupropanate, flupirsulfuron, fluridone, flurochloridone, fluroxypyr, flurtamone, fluthiaset, fomesafen, holamsulfuron, fosamine, furyloxyphene, glufosinate, glyphosate, halosafene, halosulfuron, haloxidine, haloxyhop- P, hexazinone, imazametabenz, imazamox, imazapi , Imazapill, imazaquin, imazepine, imazosulfuron, indanophan, indazifram, iodobonyl, iodosulfuron, ioxonyl, ipadine, ipfencarbazone, iprimidum, isocarbamide, isosil, isomethiodine, isonorlone, isopolylone, isoproparin, isoprolone , Isoxachlortol, isoxaflutol, isoxapyrihop, carbbutyrate, ketospiradox, lactofen, lenacyl, linuron, MCPA, MCPA-thioethyl, MCPB, mecoprop, mecoprop-P, mezinoterb, mefenacet, mefluidide, mesoprazine, Mesosulfuron, Mesotrione, Metam, Metamihop, Metamitron, Metazachlor, Metazo Sulfuron, Metoflurazon, Metabenzthiazulone, Metalproparin, Methazole, Methiobencarb, Methiozoline, Methiuron, Methiuron, Metomethon, Metoprotolin, Methyldaimron, Metobenzuron, Metobromulone, Metrachlor, S-metolachlor, Metholamme, Methothrone, Methothrone Molinate, monalide, monisouron, monochloroacetic acid, monolinuron, monuron, morpham quat, naproanilide, napropamide, naptalam, nebulon, nicosulfuron, nipyraclofen, nitralin, nitrophene, nitrofluorfen, norflurazon, norlon, OCH, olvencurve, orthosulfamlone , Oryzalin, oxadiargyl, oxadiazone, oxapyrazone Oxasulfuron, oxadiclomephone, oxyfluorfen, paraflulon, paraquat, pebrate, pelargonic acid, pendimethalin, penoxsulam, pentanochlor, pentoxazone, perfluidone, petoxamide, phenicofam, fenmedifam, fenmedifam-ethyl, phenobenzuron, picloramen, Picolinaphen, pinoxaden, piperophos, pretilachlor, primisulfurone, procyanidin, prodiamine, profluazole, profluralin, propoxydim, proglinazine, prometon, promethrin, propachlor, propanyl, propaxahop, propazine, profam, propisochlorol, propoxycarbazone , Propyrisulfuron, propyzamide, prosul Aline, Prosulfocarb, Prosulfuron, Proxan, Prinachlor, Pidanone, Pyraclonyl, Pyraflufen, Pyrasulfotol, Pyrazolate, Pyrazosulfuron, Pyrazoxifene, Pyribenoxime, Pyributycarb, Pyrichlor, Pyridafol, Pyridate, Pyriphthalide, Pyriminobac, Pyrisulfur, Pyrithiobac Sasulfone, piroxithram, quinclolac, quinmelac, quinoclamine, quinonamide, quizalofop, quizalofop-P, rhodetanyl, rimsulfuron, cebuthylazine, sectibumetone, cetoxidim, ciduron, simazine, simeton, cimetrin, sulcotrione, sulfatrazone, sulfentrazone Sulfomethulone, Sulfosulfuron, Sulglycapine, Swep, Tebuta , Tebuthiuron, tefryltrione, tembotrione, tepraxidim, terbacyl, terbucarb, terbuchlor, terbumethone, terbutyrazine, terbutridine, tetrafluron, tenylchlor, thiazaflulone, thiazopyr and triclopyr, thiadimine, thiazulone, thiencarbazone-ful Thiocarbazyl, thiochlorim, topramezone, tolcoxidim, trialate, trisulfuron, triadifram, tribenuron, tricamba, tridiphan, trietadine, trifloxysulfuron, trifluralin, triflusulfuron, trihop, trihoppsim, trihydroxytriazine, trimethuron, tripropindane, tritaclone , Tritosulfuron, Verno Over door, Kishirakuroru, as well as the following formula

［式中、
Ａｒは、ハロゲン、Ｃ_１〜Ｃ_６アルキル、Ｃ_１〜Ｃ_６アルコキシ、Ｃ_２〜Ｃ_４アルコキシアルキル、Ｃ_２〜Ｃ_６アルキルカルボニル、Ｃ_１〜Ｃ_６アルキルチオ、Ｃ_１〜Ｃ_６ハロアルキル、Ｃ_１〜Ｃ_６ハロアルコキシ、Ｃ_２〜Ｃ_４ハロアルコキシアルキル、Ｃ_２〜Ｃ_６ハロアルキルカルボニル、Ｃ_１〜Ｃ_６ハロアルキルチオ、−ＯＣＨ_２ＣＨ_２−、−ＯＣＨ_２ＣＨ_２ＣＨ_２−、−ＯＣＨ_２Ｏ−または−ＯＣＨ_２ＣＨ_２Ｏ−から独立して選択される１個から４個の置換基で置換されているフェニル基を表し、
Ｒは、ＨまたはＦを表し、
Ｘは、Ｃｌまたはビニルを表し、
Ｙは、Ｃｌ、ビニルまたはメトキシを表す］
の化合物、ならびに例えばＵＳ７３１４８４９Ｂ２、ＵＳ７３００９０７Ｂ２、ＵＳ７７８６０４４Ｂ２およびＵＳ７６４２２２０Ｂ２において開示されているそれらの塩およびエステルの１種または複数から選択することができる。

[Where:
Ar is _halogen, C 1 -C _{6 alkyl,} C 1 -C _{6 alkoxy,} C 2 -C _{4 alkoxyalkyl,} C 2 -C _{6 alkylcarbonyl,} C 1 -C _{6 alkylthio,} C 1 -C ₆ haloalkyl, C ₁ -C _{6 haloalkoxy,} C 2 -C ₄ halo _alkoxyalkyl, C 2 -C _{6 haloalkylcarbonyl,} C 1 -C _{6 haloalkylthio, -OCH 2 CH 2 -, -} OCH 2 CH 2 CH 2 -, - OCH Represents a phenyl group substituted with 1 to 4 substituents independently selected from ₂ O- or -OCH ₂ CH ₂ O-;
R represents H or F;
X represents Cl or vinyl;
Y represents Cl, vinyl or methoxy]
And one or more of their salts and esters disclosed, for example, in US7314849B2, US73000907B2, US7786044B2 and US7664220B2.

  In some embodiments, the herbicidal active ingredient and derivatives thereof are 2,4-D, 2,4-DB, aminocyclopyranchlor, aminopyralide, bromoxynyl, chlorsulfuron, cletodim, clodinahop, clopyralid, cihalohop, dicamba. , Phenoxaprop, florasulam, fluazifop, fluazifop-P, fluroxypyr, glufosinate, glyphosate, haloxyhop, haloxyhop-R, imazamox, imazapic, iodosulfuron, ioxonyl, MCPA, mesosulfuron, mesotrione, metamihop, metosulm, methosulfram Picloram, Pinoxaden, Propizaphop, Piroxithram, Quinchlorac, Quizalofop, Cetoxidim, Thifensulfuron-meth , Tribenuron, triclopyr or the following formula,

［式中、
Ａｒは、ハロゲン、Ｃ_１〜Ｃ_６アルキル、Ｃ_１〜Ｃ_６アルコキシ、Ｃ_２〜Ｃ_４アルコキシアルキル、Ｃ_２〜Ｃ_６アルキルカルボニル、Ｃ_１〜Ｃ_６アルキルチオ、Ｃ_１〜Ｃ_６ハロアルキル、Ｃ_１〜Ｃ_６ハロアルコキシ、Ｃ_２〜Ｃ_４ハロアルコキシアルキル、Ｃ_２〜Ｃ_６ハロアルキルカルボニル、Ｃ_１〜Ｃ_６ハロアルキルチオ、−ＯＣＨ_２ＣＨ_２−、−ＯＣＨ_２ＣＨ_２ＣＨ_２−、−ＯＣＨ_２Ｏ−または−ＯＣＨ_２ＣＨ_２Ｏ−から独立して選択される１個から４個の置換基で置換されているフェニル基を表し、
Ｒは、ＨまたはＦを表し、
Ｘは、Ｃｌまたはビニルを表し、
Ｙは、Ｃｌ、ビニルまたはメトキシを表す］
の化合物、ならびにそれらの塩およびエステルである。

[Where:
Ar is _halogen, C 1 -C _{6 alkyl,} C 1 -C _{6 alkoxy,} C 2 -C _{4 alkoxyalkyl,} C 2 -C _{6 alkylcarbonyl,} C 1 -C _{6 alkylthio,} C 1 -C ₆ haloalkyl, C ₁ -C _{6 haloalkoxy,} C 2 -C ₄ halo _alkoxyalkyl, C 2 -C _{6 haloalkylcarbonyl,} C 1 -C _{6 haloalkylthio, -OCH 2 CH 2 -, -} OCH 2 CH 2 CH 2 -, - OCH Represents a phenyl group substituted with 1 to 4 substituents independently selected from ₂ O- or -OCH ₂ CH ₂ O-;
R represents H or F;
X represents Cl or vinyl;
Y represents Cl, vinyl or methoxy]
And their salts and esters.

  Additional exemplary herbicidal active ingredients for use in the methods and compositions described herein have the formula

の化合物、およびそのＣ_１〜Ｃ_６アルキルエステルまたは塩の誘導体、例えばメチルエステルなど、ならびに式

And derivatives of C ₁ -C ₆ alkyl esters or salts thereof, such as methyl esters, and the formula

の化合物、およびそのＣ_１〜Ｃ_１２アルキルエステルまたはＣ_７〜Ｃ_１２アリールアルキルエステルまたは塩の誘導体、例えばベンジルエステルなどである。

And C ₁ -C ₁₂ alkyl esters or C ₇ -C ₁₂ arylalkyl esters or salt derivatives thereof such as benzyl esters.

  In some embodiments, the active ingredient is fluroxypyrmeptyl.

Exemplary pesticide active ingredients and derivatives thereof for use in the methods and compositions described herein include, but are not limited to, abamectin, acephate, acetamiprid, acethione, acetoprole, acrinathrin, alanic carb , Aldicarb, Aldoxycarb, Aresulin, Allosamidin, Alixicarb, Amididione, Aminocarb, Amiton, Amitraz, Anabasine, Atidathione, Azadirachtin, Azamethiphos, Adinphos-ethyl, Adinphos-methyl, Azotoate, Balthrin, Bendiocarb, Benthalbifento Allethrin, bioethanomethylin, biopermethrin, violesmethrin, bistriflurone, bromfenbinphos, bromophos Bromophos-ethyl, bufencarb, buprofezin, butacarb, butathiophos, butocarboxyme, butonate, butoxycarboxyme, kazusafos, carbanolate, carbaryl, carbofuran, carbophenothione, carbosulfan, cartap, chlorantraniliprole (rynaxypyr), chlordimeform , Chlorethoxyphos, Chlorfenapyr, Chlorfenvinfos, Chlorfluazuron, Chlormefos, Chlorfoxime, Chlorprazofos, Chlorpyrifos, Chlorpyrifos-methyl, Chlorthiophos, Chromafenozide, Cineline I, Cineline II, Cineline, Cismethrin, Chloethocarb , Cumitoate, crotamiton, crotoxifos, culfomate, cyanophthal Nhosu, cyanophos, Shiantoeto, cyan tiger Niri Prowl (cyantranili po le), Shiajipiru, Shikuretorin, cycloalkyl, cyfluthrin, beta - cyfluthrin, cyhalothrin, gamma - cyhalothrin, lambda - cyhalothrin, cypermethrin, alpha - cypermethrin, beta - Cypermethrin, theta-cypermethrin, zeta-cypermethrin, ciphenothrin, cyromazine, cithioate, decarbofuran, deltamethrin, demefione, demefione-O, demefione-S, demeton, demeton-methyl, demeton-O, demeton-O-methyl , Demeton-S, demeton-S-methyl, demeton-S-methylsulfone, difenthiuron, diarifos, diazinon, dicapton, diclofenthion, dichrome Boss, Dicresyl, Dicrotophos, Dicyclanil, Diflubenzuron, Dimefluthrin, Dimefox, Dimethoate, Dimethrin, Dimethylvinphos, Dimethylan, Dimitan, Dinex, Dinoprop, Dinosum, Dinotefuran, Diophenolane, Dioxabenzophos, Dioxacarbone, Dioxathione, D , Doramectin, α-ecdysone, ecdysterone, emamectin, EMPC, empentrin, endothion, EPN, epofenonane, eprinomectin, esfenvalerate, ethafos, etiophencarb, ethione, ethiprole, ethoate-methyl, ethoprox, etofenprox, D , Fanful, Phenamifos, Phenazaflor, Phenazaquin, Fenchlorphos, phenetacarb, fenfluthrin, fenitrothion, fenobucarb, phenoxacrime, phenoxycarb, fenpyritrin, fenpropoxyline, fenpyroximate, fensulfothion, fenthion-ethyl, fenvalerate, fipronil, flonicamid, fulvendiamide, fulveneamide Diamide, flucoflon, flucycloxuron, flucitrinate, flufenelim, flufenoxuron, flufenprox, fulvalinate, tau-fulvalinate, phonofos, formethanate, formotethione, formparanate, phosmethylan, hospirate, phostietane, furthiocarb, fretrin , Halfenprox, halofenozide, heptenophos, heterophos, hex Flumuron, hydramethylnon, hydroprene, hykincarb, imisiaphos, imidacloprid, imiprothrin, indoxacarb, IPSP, isazophos, isocarbophos, isofenphos, isoprocarb, isoprothiolane, isothioate, isoxathion, ivermectin, jasmoline I, jujusmoline II, iodophos Hormone I, juvenile hormone II, juvenile hormone III, quinoprene, lepimectin, leptofos, d-limonene, lirinfos, rufenuron, ritidathione, malathion, malonoben, majidox, mecarbam, mecarphone, menazone, mephospholane, mesulfenphos, metaflumizone, metacrimis, Methamidophos, methidathion, methiocarb, metocrotofos, methomyl, metho Len, methoxyphenozide, metfurthrin, metorcarb, methoxadiazone, mevinphos, mexacarbate, milbemectin, milbemycin oxime, mipafox, monocrotophos, morphothion, moxidectin, naphthalophos, naredo, nicotine, nifluride, nitenpyram, nithiazine, nitrilotron, nitrilotron Oxamyl, oxydemeton-methyl, oxydeprophos, oxydisulfoton, parathion, parathion-methyl, penflurone, permethrin, fencapton, phenothrin, phentoate, folate, hosalon, phospholane, phosmet, fosnichlor, phosphamidone, oxime, oxime-methyl, pyrimethaphos, Pirimicarb, pirimiphos-ethyl, Pirimiphos-methyl, praretrin, plecocene I, plecocene II, plecocene III, primidophos, profenofos, profluthrin, promacil, promecarb, propaphos, propethanphos, propoxer, protidathione, prothiophos, protoate, protrifenbut, pyracrophos, pyrafluprole, pyrazophos, pyrazophos Pyrethmethrin, pyrethrin I, pyrethrin II, pyrethrins, pyridaben, pyridalyl, pyridafenthione, pyrifuraquinazone, pyrimidifen, pyrimidate, pyriprole, pyriproxyfen, cassia, quinalphos, quinalphos-methyl, quinothione, rafoxanide, resmethrin, danslatriad, riathrazradilazia , Ceramectin, silafluophene, couchamide, spinet , Spinosad, 21-butenylspinosine, spirodiclofen, spiromesifen, spirotetramat, sulcofuron, sulfotep, sulfoxafurol, sulprophos, tadimcarb, tebufenozide, tebufenpyrad, tebupyrimphos, teflubenzuron, tefluthrin, temefos, TEPP, terrareslin , Terbufos, tetrachlorbinphos, tetramethrin, thiacloprid, thiamethoxam, ticlofos, thiocarboxyme, thiocyclam, thiodicarb, thiophanox, thiometon, thiosultap, thuringensin, tolfenpyrad, tralomethrin, transfluthrin, transpermethrin, trilatene, Triazamethate, triazophos, trichlorfone, trichlorometaphos-3, Rikuroronato, Torifenohosu, triflumuron, trimethacarb, triprene, vamidothion, vaniliprole, XMC, include one or more xylylcarb and Zorapurohosu. Particularly suitable pesticide active ingredients and derivatives thereof include chlorpyrifos, chlorpyrifos-methyl, clothianidin, cyanipir, lambda-cyhalothrin, deltamethrin, dinotefuran, flonicamid, fulvendiamide, imidacloprid, linaxpyr, spinetoram, spinosad, 21-butenylspinosine , Sulfoxafurol and thiacloprid.

  Exemplary fungicidal active ingredients and derivatives thereof for use in the methods and compositions described herein include, but are not limited to, amethoctrazine, amisulbrom, ampropylphos, anilazine, antimycin, Azaconazole, Adithyram, Azoxystrobin, Barium polysulfide, Bayer32394, Benalaxyl, Benodanyl, Benomyl, Benquinox, Ventallon, Benchavalicarb-isopropyl, Benzamacryl; Benzamacryl-isobutyl, benzamorph, benzylaminobenzene-sulfonate (BABS) salt , Binapacryl, biphenyl, bismerthiazole, viteltanol, bixaphene, blasticidin-S, boscalid, bromconazole, bupyrimeto, butiobate, YF1047, captaphore, captan, carbamorph, carbendazim, carboxin, carpropamide, carvone, CECA, clobenazone, chloraniformane, chlorphenazole, 1-chloro-2,4-dinitronaphthalene, chloronebu, chlorothalonil, chloro Knox, clozolinate, crimbazole, copper bis (3-phenylsalicylate), coumarin, cuprobam, cyazofamide, cyclamfamide, cyflufenamide, simoxanyl, cipendazole, cyproconazole, cyprodinil, cyprofram, dazomet, decacarb, decafentin, diammonium ethylenebis Acid), dichlorofluanide, dicron, dichlorane, 3- (4-chlorophenyl) -5-methylrhodanine, dichloro Phen, (RS) -N- (3,5-dichlorophenyl) -2- (methoxymethyl) -succinimide, N-3,5-dichlorophenylsuccinimide, 1,3-dichloro-1,1,3,3-tetra Fluoroacetone hydrate, diclozoline, diclobutrazole, diclocimet, diclomedin, dietofencarb, diphenoconazole, difenzocote ion, diflumetrim, dimethymol, dimethomorph, dimoxystrobin, diniconazole, diniconazole-M, dinocup, dinoctone, dinosulfone, Dinoterbon, diphenylamine, dipyrithione, ditalimphos, dithianone, dodemorph, dodemorph acetate, dodicine, dodin, dodin free base, drazoxolone, EBP, edifenphos, enestrobin, epoxy Conazole, ESBP, ethaconazole, etem, ethaboxam, etirim, ethoxyquin, N-ethylmercurio-4-toluenesulfonanilide, etridiazole, famoxadone, fenamidone, phenaminosulfur, phenapanil, fenarimol, fenbuconazole, fenflam, fenhexamide , Fenitropan, Phenoxanyl, Fenpiclonyl, Fenpropidin, Fenpropimorph, Fenpyrazamine, Fentine, Fentine Acetate, Fentine Hydroxide, Farbum, Ferimzone, Fluazinam, Fludioxonil, Flumorph, Fluopicolide, Fluopyram, Fluorimide, Fluotrimazole, Fluoxastrobin, fluquinconazole, flusilazole, fursulfamide , Flutolanil, flutriaphor, fluxapyrad, phorpet, formaldehyde, fosetyl, fosetyl-aluminum, fuberidazole, flaxil, furametopyr, furcarbanil, fluconazole, fluconazole-cis, flumecyclox, furofanate, gliodin, griseofulvin, guazatine, guazatine, guazatine, guazatine, GY-81, haracrinate, 2- (2-heptadecyl-2-imidazolin-1-yl) ethanol, Hercules 3944, hexaconazole, hexylthiophos, 8-quinoline sulfate, himexazole, ICIA0858, IK-1140, imazalyl, imazalyl sulfate, Imibenconazole, iminoctadine, iminoctadine triacetate, iminoctadine tris (Albesi ), Ipconazole, iprobenfos, iprodione, iprovaricarb, isopamufos, isoprothiolane, isopyrazam, isothianyl, isovaradione, kasugamycin, kasugamycin hydrochloride hydrate, cresoxime-methyl, mankappa, mancozeb, mandipropamide, maneb, mebenpimeme, mecarpinomeme Mepronil, Meptyldino Cup, Meptyl Dinocap, Metalaxyl, Metazoxolone, Metoconazole, Metasulfocarb, Metofuroxam, Methylmercuricyanocyanide, Methylam, Metominostrobin, Metraphenone, Metosulfobax, Mildiomycin, Milneb, Mucochloric Anhydride , Microbutanyl, Microzoline, Nervam, Natamycin, Nickel Bis Dimethyldithiocarbamate), N-3-nitrophenylitaconimide, nitrotar-isopropyl, nuarimol, OCH, octylinone, off race, orisatrobin, oxadixyl, oxine-copper, oxpoconazole fumarate, oxycarboxyl, pefazoate, penconazole, Pencyclon, Penflufen, Pentachlorophenol, Pentachlorophenyl laurate, Penthiopyrad, 2-Phenylphenol, Phosdiphen, Phthalide, Pixoxystrobin, Polyoxin B, Polyoxin, Polyoxolim, Hydroxyquinoline potassium sulfate, Probenazole, Prochloraz, Procimidone, Propamocarb, Hydrochloric acid Propamocarb, propiconazole, propineb, proquinazide, prothiocarb, hydrochloric acid Lothiocarb, prothioconazole, pyracarbolido, pyraclostrobin, pyraxostrobin, pyrazophos, pyribencarb, pyributicarb, pyridinitrile, pyrifenox, pyrimethanil, pyriophenone, pyromethostrobin, pyroxylone, pyroxicurol, pyroxylful Quinacetol; quinacetol sulfate, quinazamide, quinconazole, quinocramine, quinoxyphene, quintozen, ravenzazole, Reynoutria sachalinensis extract, salicylanilide, sedaxane, silthiofam, simeconazole, sodium 2-phenylphenoxide, sodium pentachlorophenoxide, sodium pentachlorophenoxide, sodium pentachlorophenoxide , SSF-109, sultropene, SYP-048, SY -Z048, SYP-Z071, tebuconazole, tebufloquine, technazen, tecolene, tetraconazole, thiabendazole, thiadifluor, thiosiophene, tifluzamide, thiochlorfenfim, 2- (thiocyanatomethylthio) -benzothiazole, thiophanate, thiophanate-methyl, Thioquinox, thyram, thiazinyl, thioximide, tolcrofos-methyl, tolylfuranide, triadimethone, triadimenol, triamifos, triarimol, triazbutyl, triazoxide, trichlamido, tricyclazole, tridemorph, triproxystrobin, triflumizole, triforin, tri Ticonazole, UK-2A, derivatives of UK-2A, for example having a CAS registry number of 328255-92-1 ( 3S, 6S, 7R, 8R) -8-Benzyl-3- (3- (isobutyryloxymethoxy) -4-methoxypicolinamide) -6-methyl-4,9-dioxo-1,5-dioxonan-7 -One or more of urubaside, validamycin, valifenate, varifenal, vinclozolin, XRD-563, zaliramide, dineb, ziram and zoxamide, such as ylisobutyrate. Particularly suitable fungicidal active ingredients and their derivatives include azoxystrobin, bixafen, boscalid, carbendazim, carpropamide, chlorothalonil, epoxiconazole, fenbuconazole, fenpropidin, fenpropimorph, fluoxastrobin , Flusilazole, floxapyrado, isopyrazam, isothianyl, kasugamycin, meptyl dinocap, metconazole, metraphenone, microbutanyl, orisatrobin, penconazole, pencyclon, penthiopyrad, picoxystrobin, probenazole, prochloraz, propiconazole, prothioconazole, pyraclostrobin , Quinoxyphene, spiroxamine, tebuconazole, tifluzamide, triazimephone, tricyclazole, tri Fenpropimorph include trifloxystrobin and validamycin.

  Exemplary herbicide safety agents for use in the methods and compositions described herein include, but are not limited to, the following active ingredients and their derivatives such as benoxacol, beniocarb, croquint Set, Dimelon, Dichlormide, Dicyclonone, Dimepiperate, Fenchlorazole, Fenchlorim, Flurazole, Fluxophenim, Furirazole, Harpin protein, Isoxadifen, Mefenpyr, Mephenate, MG 191, MON 4660, Naphthalic anhydride (NA), Oxabetrinil, R29148 and One or more of N-phenyl-sulfonylbenzoic acid amide and the like can be mentioned.

  Exemplary bactericides for use in the methods and compositions described herein include, but are not limited to, bronopol, dichlorophen, kasugamycin, nitrapiline, octyrinone, oxophosphate, streptomycin, One or more of teclophthalam, 8-hydroxyquinoline, sulfaquinoxaline, oxytetracycline, copper octoate and 2- (thiocyanatomethylthio) benzothiazole, and derivatives thereof. A particularly suitable bactericide is nitrapiline.

  The water soluble aggregation inhibitors used in the methods and compositions described herein generally have high water solubility (greater than about 20% by weight; w / w basis). In some embodiments, the solubility is at least 20%, 30%, 40%, 50% or 60% by weight; on a w / w basis. Examples of aggregation inhibitors include, but are not limited to, ionic compounds such as inorganic acids and inorganic salts of organic acids, hyperoxygenated compounds such as carbohydrates, and nitrogen-containing compounds such as nitrogen fertilizers. . Suitable ionic compounds include alkali metal salts, magnesium salts, calcium salts and ammonium salts of inorganic and organic acids such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, carbonic acid and acetic acid. Exemplary carbohydrates include, but are not limited to, monosaccharides, disaccharides, oligosaccharides, polysaccharides, and mixtures thereof. Carbohydrates can include, for example, glucose, fructose, sucrose, trehalose, lactose and maltose, dextrin, and starch. Suitable nitrogen fertilizers may include urea, ammonium sulfate, ammonium nitrate, potassium chloride, and polymers containing or derived from urea.

  In some embodiments, the water soluble aggregation inhibitor is a salt of an inorganic acid or an organic acid. In certain embodiments, the water soluble aggregation inhibitor is a salt of an inorganic acid. In some embodiments, the aggregation inhibitor is an alkali metal salt, alkaline earth metal salt or ammonium salt. In some embodiments, the aggregation inhibitor is sulfate, nitrate or citrate. In certain embodiments, the aggregation inhibitor is magnesium sulfate or ammonium nitrate. In some embodiments, the water soluble aggregation inhibitor is ammonium sulfate. In some embodiments, the water soluble aggregation inhibitor is a carbohydrate. In some embodiments, the aggregation inhibitor is an alkali metal, magnesium, calcium and ammonium salt of inorganic and organic acids such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, carbonic acid and acetic acid, such as sodium chloride, chloride. Potassium, magnesium chloride, calcium chloride, ammonium chloride, sodium sulfate, potassium sulfate, magnesium sulfate, sodium nitrate, potassium nitrate, monosodium phosphate, mono, di and tripotassium phosphate, sodium carbonate, sodium bicarbonate, potassium carbonate, heavy Inorganic or organic acid salts including potassium carbonate, sodium acetate, potassium acetate, and ammonium acetate; fertilizers such as ammonium sulfate, mono-, di- and triammonium phosphate, ammonium nitrate, and urea; glucose, fructose , Galactose, monosaccharides such as xylose and ribose; mixtures of any of the well aggregation inhibitor as described herein; sucrose, lactose, disaccharides such as trehalose and maltose. The aggregation inhibitor of the present invention is present in an amount of about 20 g / kg to about 900 g / kg based on the total composition. In some embodiments, the inhibitor is present in an amount from about 20 g / kg to about 800 g / kg. In some embodiments, the inhibitor is present in an amount from about 20 g / kg to about 750 g / kg.

  The water-soluble aggregation inhibitor is usually used at a very high concentration in the aqueous binder solution. The aqueous binder solution is at least 50% saturated with an aggregation inhibitor. In certain embodiments, it is at least 70% saturated with an aggregation inhibitor. In certain embodiments, it is at least 80% saturated with an aggregation inhibitor. In certain embodiments where processing the dough into granules having improved dispersion properties in water is performed at higher temperatures (above room temperature), the concentration of the aggregation inhibitor in the aqueous binder solution is adjusted. Thus, it is possible to compensate for the increase in solubility of the aggregation inhibitor in water at a temperature exceeding room temperature. Aggregation inhibitors reduce or inhibit agglomeration or coagulation of the granule components, particularly during processing of the dough into granules at temperatures above room temperature, thereby improving the dispersion characteristics of the granules in water. Agglomeration inhibitors are used in high shear processing conditions, such as during high shear processing conditions encountered during high shear extrusion of dough into stable high quality granules with improved dispersion properties in water. It is also possible to reduce or inhibit the aggregating action or coagulation of the components.

  The mixing method of the aggregation inhibitor can be easily determined by those skilled in the art. Exemplary methods include, but are not limited to, (1) dissolving an aggregation inhibitor in water, (2) a dry form aggregation inhibitor containing the active ingredient formed in step (a). Adding to the powder or (3) using a powder that already contains the aggregation inhibitor used in step (a). A powder that already contains an aggregation inhibitor can be made, for example, by adding the aggregation inhibitor to a processing step that generates the powder.

  In some embodiments, a powder blend mixture containing water, an aggregation inhibitor, and an active ingredient is processed via a high shear granulation process. In some embodiments, the process is via extrusion.

  The compositions described herein include at least one of a solid anionic surfactant or a solid nonionic surfactant. Solid anionic surfactants that can be used include, but are not limited to, lignosulfonates, alkyl naphthalene sulfonate formaldehyde condensates, dialkyl sulfosuccinate salts and alkyl sulfonate salts. Solid nonionic surfactants that can be used include, but are not limited to, polyvinyl alcohol, polyacrylate, polyethylene oxide, polyvinyl pyrrolidone and copolymers, derivatives and mixtures thereof, polyol fatty acid esters, polyethoxylated esters, polyethoxy Amine ethoxylates, sorbitan fatty acid ester ethoxylates, and sucrose esters of fatty acids such as alkylated alcohols, alkyl polysaccharides such as alkyl polyglycosides (APG type) and blends thereof.

  In some embodiments, solid anionic and solid nonionic surfactants for use in the methods and compositions described herein are Celvol® 205 (Sekisui Chemical Co.). , Ltd., Dallas, TX), polyvinyl alcohol derived from the hydrolysis of polyvinyl acetate, varying from about 87% to about 99% degree of hydrolysis, Agneque® PG 9116 (Cognis, Cincinnati, OH) is an example of an alkyl polyglycoside (APG type), Borresperse® NA (registered trademark of Borregarard LignoTech) and Polyfon® F (Meadwestvaco, Richmond, VA) Lignosulfonate is, as well as Morwet (R) D425 (AkzoNobel, Chicago, IL) is an alkyl naphthalene sulfonate-formaldehyde condensate is an example, and copolymers thereof, derivatives and mixtures thereof. At least one solid anionic surfactant or solid nonionic surfactant, based on the total composition, from about 10 g / kg to about 250 g / kg, preferably from about 10 g / kg to about 150 g / kg, and Most preferably it is present in an amount of about 20 g / kg to about 150 g / kg.

  The compositions described are optionally, but not limited to, adjuvants, antifoaming agents, antimicrobial agents, compatibilizers, corrosion inhibitors, dispersants, dyes, emulsifiers, neutralizing agents and buffering agents. One or more additional inert ingredients such as odorants, penetration aids, scavengers, diffusion agents, stabilizers, sticking agents and suspension aids may be included.

  Adjuvants (also known in the art as built-in adjuvants) that may optionally be included in the described compositions include biology against pests such as weeds, insects and fungal pathogens. That can improve the effectiveness of the system. Suitable built-in adjuvants are solid at ambient temperature and include one or more of non-ionic surfactants. Nonionic surfactants that can be used as built-in adjuvants include, but are not limited to, polyol fatty acid esters, polyethoxylated esters, polyethoxylated alcohols, alkyl polysaccharides such as alkyl polyglycosides (APG type) and the like. And the like, amine ethoxylates, sorbitan fatty acid ester ethoxylates, and sucrose esters of fatty acids.

In one embodiment, herein,
a) preparing a powder comprising a pesticidal active ingredient;
b) adding water to the powder;
There is provided a method for improving the dispersibility characteristics of pesticide-containing granules in water comprising c) blending said powder and water into a mixture, and d) processing said mixture into granules, wherein The improvement method is characterized in that one or more water-soluble aggregation inhibitors are mixed in the powder or water before blending, and the amount of the one or more aggregation inhibitors is at least the step (b) ) Is the amount required to achieve 50% of the saturation concentration in the amount of water added in
i) The pesticidal active ingredient is 2,4-D, 2,4-DB, aminocyclopyrochlor, aminopyralide, bromoxynyl, chlorsulfuron, cretodim, clodinap, clopyralid, cyhalohop, dicamba, phenoxaprop, Fluoraslam, fluazifop, fluazifop-P, fluroxypyr, glufosinate, glyphosate, haloxyhop, haloxyhop-R, imazamox, imazapic, iodosulfuron, oxynyl, MCPA, mesosulfuron, mesotrione, metamihop, metoslam, metsulfurnone, penoxprompiran Kizahop, piroxyslam, quinclolac, quizalofop, cetoxydim, thifensulfuron-methyl, tribenuron, triclo Le, the formula I

の化合物、またはそのＣ_１〜Ｃ_６アルキルエステルもしくは塩、
または式ＩＩ

Or a C ₁ -C ₆ alkyl ester or salt thereof,
Or formula II

の化合物、またはそのＣ_１〜Ｃ_１２アルキルエステルもしくはＣ_７〜Ｃ_１２アリールアルキルエステルもしくは塩であり、
ｉｉ）前記１種または複数の水溶性凝集抑制剤は、アルカリ金属塩、アルカリ土類金属塩、アンモニウム塩、硫酸塩、硝酸塩またはクエン酸塩であり、
ｉｉｉ）前記１種または複数の凝集抑制剤の量は、少なくとも、ステップ（ｂ）において添加された水の量における飽和濃度の７０％を達成するために必要とされる量である。

Or a C ₁ -C ₁₂ alkyl ester or C ₇ -C ₁₂ arylalkyl ester or salt thereof,
ii) the one or more water-soluble aggregation inhibitors are alkali metal salts, alkaline earth metal salts, ammonium salts, sulfates, nitrates or citrates;
iii) The amount of the one or more aggregation inhibitors is the amount required to achieve at least 70% of the saturation concentration in the amount of water added in step (b).

In one embodiment, herein,
e) providing a powder comprising a pesticidal active ingredient;
f) adding water to the powder;
There is provided a method for improving the dispersibility characteristics of a pesticide-containing granule in water comprising g) blending the powder and water into a mixture, and h) processing the mixture into granules, wherein The improvement method is characterized by mixing one or more water-soluble aggregation inhibitors in powder or water prior to blending, wherein the amount of the one or more aggregation inhibitors is at least step (b) Is the amount required to achieve 50% of the saturation concentration in the amount of water added in
i) the pesticidal active ingredient is fluroxypyrmeptyl;
ii) the one or more water-soluble aggregation inhibitors are magnesium sulfate, ammonium sulfate or ammonium nitrate;
iii) The amount of the one or more aggregation inhibitors is the amount required to achieve at least 70% of the saturation concentration in the amount of water added in step (b).

In one embodiment, herein,
i) providing a powder comprising a pesticidal active ingredient;
j) adding water to the powder;
k) A method is provided for improving the dispersibility characteristics of pesticide-containing granules in water, comprising blending said powder and water into a mixture, and l) processing said mixture into granules, wherein The improvement method is characterized in that one or more water-soluble aggregation inhibitors are mixed in the powder or water before blending, and the amount of the one or more aggregation inhibitors is at least the step (b) ) Is the amount required to achieve 50% of the saturation concentration in the amount of water added in
iv) the pesticidal active ingredient is fluroxypyrmeptyl;
v) the one or more water-soluble aggregation inhibitors are magnesium sulfate, ammonium sulfate or ammonium nitrate; vi) the amount of the one or more aggregation inhibitors is at least the water added in step (b) The amount required to achieve 70% of the saturation concentration in the amount,
vii) The processing in step (d) is performed by utilizing a high shear granulation process.

In some embodiments, the method of producing the pesticide-containing granule comprises:
(I) adding water to the powder,
a. The powder comprises a pesticidal active ingredient;
b. One or more water-soluble aggregation inhibitors are incorporated into one of the water or powder, wherein the amount of the water-soluble aggregation inhibitor incorporated is at least a saturation concentration in the amount of water added. A step that is the amount needed to achieve 50% of the
(Ii) blending the powder and water into a mixture, and (iii) processing the mixture into granules.

Examples of methods for improving the dispersion characteristics of pesticide-containing granules in water are:
a) preparing a powder containing spray-dried microencapsulated fluroxypyrmeptyl;
b) adding water to the powder;
c) blending the powder and water into a mixture, and d) processing the mixture into granules, wherein the improved method is characterized by mixing ammonium sulfate with water prior to blending. Where the amount of ammonium sulfate is the amount required to achieve at least 50% of the saturation concentration in the amount of water added in step (b).

In this specification,
d) about 10 grams per kilogram (gai / kg) to about 900 gai / kg of pesticide active ingredient relative to the total composition;
e) about 20 grams per kilogram (g / kg) to about 900 g / kg per kilogram of total composition, and f) solid anionic surfactant and solids based on total composition About 10 g / kg to about 300 g / kg of at least one nonionic surfactant
Also provided are pesticide-containing granules having improved dispersion properties in water.

  In some embodiments, the granule comprises about 100-300 g / kg of a water soluble aggregation inhibitor. In some embodiments, the granule comprises about 50-400 g / kg of a water soluble aggregation inhibitor. In some embodiments, the granule comprises about 50-600 g / kg of a water soluble aggregation inhibitor. In some embodiments, the granule comprises about 100-700 g / kg of a water soluble aggregation inhibitor. In some embodiments, the granule has at least 20 g / kg, 50 g / kg, 100 g / kg, 150 g / kg, 200 g / kg, 250 g / kg, 300 g / kg, 400 g / kg or 500 g of water-soluble aggregation inhibitor. / Kg included.

  In some embodiments, the granule comprises at least 20 g / kg of at least one of a solid anionic surfactant and a solid nonionic surfactant. In some embodiments, the granule comprises at least 40 g / kg of at least one of a solid anionic surfactant and a solid nonionic surfactant. In some embodiments, the granule comprises at least 60 g / kg of at least one of a solid anionic surfactant and a solid nonionic surfactant. In some embodiments, the granule comprises at least 80 g / kg of at least one of a solid anionic surfactant and a solid nonionic surfactant. In some embodiments, the granule comprises at least 100 g / kg of at least one of a solid anionic surfactant and a solid nonionic surfactant. In some embodiments, the granule comprises at least 150 g / kg of at least one of a solid anionic surfactant and a solid nonionic surfactant.

In some embodiments, the pesticide-containing granule having improved dispersion properties in water is
a) about 10 grams per kilogram (gai / kg) to about 900 gai / kg of fluroxypyrmeptyl, relative to the total composition;
b) at least 200 g / kg of a water-soluble aggregation inhibitor, and c) at least about 60 g / kg of at least one of a solid anionic surfactant and a solid nonionic surfactant.
Including.

Another embodiment relates to a pesticidal-containing granule having improved dispersion properties in water, wherein the pesticidal is fluroxypyrmeptyl. Examples of pesticide-containing granules containing the herbicide fluroxypyrmeptyl are:
a) about 900 gai / kg from about 10 grams of active ingredient (gai / kg) per kilogram of microencapsulated fluroxypyrmeptyl to the total composition;
b) about 10 grams per kilogram (g / kg) to about 900 g / kg of ammonium sulfate relative to the total composition;
c) about 10 g / kg to about 300 g / kg of polyvinyl alcohol relative to the total composition;
d) about 10 g / kg to about 300 g / kg of APG surfactant relative to the total composition;
e) Pergopak M from about 10 g / kg to about 150 g / kg for total composition, and f) Polyfon F from about 10 g / kg to about 100 g / kg for total composition.
Including.

  Microencapsulated low melt or liquid pesticide active ingredients are prepared by using interfacial polycondensation encapsulation techniques. The use of encapsulation techniques in the formulation of agricultural active ingredients is well known to those skilled in the art. See, for example, PJ Mulqueen in, “Chemistry and Technology of Agrochemical Formulations”, DA Knowles, (Kluwer Academic Publishers, 1998), pages 132-147, and discussion of the use of microencapsulation in the formulation of pesticide active ingredients. Please refer to the references cited there. Generally, the microcapsule is an interface between at least one oil-soluble monomer selected from the group consisting of, for example, diisocyanates and polyisocyanates, and at least one water-soluble monomer selected from the group consisting of, for example, diamines and polyamines. It can be prepared by polycondensation. Exemplary microcapsule formulations can be derived from interfacial polycondensation between polyisocyanates and diamines to provide polyurea microcapsule compositions.

  The microencapsulated pesticidal active ingredient begins with an oil-soluble monomer in an organic phase, optionally composed of a molten active ingredient containing an oil solvent, and an aqueous phase composed of a suitable surfactant and water. It can be prepared by emulsifying. Emulsions can be formed by homogenizing the oil-water mixture until the desired size of oil droplets suspended in water is obtained by use of low pressure or high pressure homogenization. The water-soluble monomer is then added to the mixture and reacts with the oil-soluble monomer at the water-oil interface of the oil droplets to form a capsule wall that encloses some or all of the oil droplets. For example, microencapsulated oils of various capsule sizes (diameters) and wall thicknesses by carefully adjusting the length of time that the mixture is homogenized and / or by adjusting the speed or pressure of the homogenizer Can be generated. Similarly, the amount of monomers, crosslinkers, emulsifiers and buffers, etc. can be adjusted to have various capsule sizes and wall thicknesses that can be easily prepared by one of ordinary skill in the art. Microencapsulated formulations can be made.

  Microcapsule suspensions of the pesticidal active ingredient generally include capsules having an average diameter that ranges from about 0.1 microns (μ) to about 20 μ, preferably from about 1 μ to about 15 μ.

  The polymeric capsule wall of the microencapsulated pesticidal active ingredient is about 0.5 weight percent to about 20 weight percent of the total weight of the microcapsule and its oil content, and in some embodiments about 2 weight percent. From about 10 percent by weight.

The microcapsule core containing the pesticidal active ingredient is preferably, but not limited to, aromatic hydrocarbons derived from benzene such as toluene, xylene and other alkylated benzenes and petroleum such as naphthalene derivatives. Distillates; aliphatic hydrocarbons such as hexane, octane and cyclohexane; mineral oils derived from the aliphatic or isoparaffin series, and mixtures of aromatic and aliphatic hydrocarbons; halogenated aromatic or aliphatic hydrocarbons; large Vegetable oil, seed oil or animal oil, such as bean oil, rapeseed oil, olive oil, castor oil, sunflower seed oil, palm oil, corn oil, cotton seed oil, linseed oil, palm oil, peanut oil, safflower oil, sesame oil and gill oil, and C ₁ -C ₆ mono derived from vegetable oils, seed oils or animal oils - ester Dialkylamides of short chain and saturated and unsaturated carboxylic acids of chain; C ₁ -C ₁₂ esters of aromatic carboxylic acids and dicarboxylic acids, and C ₁ -C ₁₂ esters of aliphatic and cycloaliphatic carboxylic acid Or a liquid or solid pesticidal active ingredient optionally dissolved in a water incompatible solvent such as one or more of the following.

  The core of the microcapsule containing the pesticidal active ingredient can optionally be used as a carrier for additional pesticidal or other ingredients. These pesticides or other ingredients can be dissolved or dispersed in oil and can be acaricide, algicide, antifeedant, avianicide, bactericides, bird repellent, chemical infertility Medicine, fungicide, herbicide safener, herbicide, insect attractant, insecticide, insect control agent, mammal repellent, mating disruptor, molluscicide, plant activator, plant growth regulator, It can be selected from rodenticides, synergists, litters, desiccants, semiochemicals, semiochemicals and virucidal agents.

  Oil-soluble monomers used to prepare microencapsulated agricultural active ingredients can include diisocyanates and polyisocyanates. Exemplary oil-soluble monomers include, but are not limited to, PAPI® 27 (The Dow Chemical Company, Midland, MI), isophorone diisocyanate and hexamethylene diisocyanate, and mixtures thereof.

  Water-soluble monomers used to prepare microencapsulated agricultural active ingredients can include the group consisting of diamines and polyamines. Exemplary water soluble monomers include, but are not limited to, diamines such as ethylene diamine.

  Water-soluble or dispersible surfactants used to prepare microencapsulated pesticide active ingredients may be anionic, cationic or nonionic in character, emulsifiers, wetting agents, dispersions It can be used as an agent or for other purposes. Suitable surfactants include, but are not limited to, lignosulfonates such as Kraftsperse® 25M (MeadWestvaco, Richmond, Va.), Eg alkyls such as Agneque® PG9116 (Cognis, Cincinnati, OH). Polyglycosides (APG), for example polymethyl methacrylate-polyethylene glycol graft copolymers such as Atlox® 4913 (Croda, Edison, NJ), and for example Tergitol® 15-S-7 (The Dow Chemical Company, Midland) , MI) and other alcohol ethoxylates.

  Also, adding the pesticide-containing granules having improved dispersion characteristics in water to a carrier such as water, and the resulting aqueous solution containing the dispersed pesticide active ingredient in the crop environment or non-crop Methods are provided for controlling undesirable vegetation, fungal pathogens, bacteria or insects, including using for spray application to control unwanted vegetation, fungal pathogens, bacteria or insects in the environment.

  Water-dispersible granule preparations can be processed by the following processing methods: (1) bread or drum granulation, (2) mixed agglomeration, (3) extrusion granulation, (4) fluid bed granulation or (5) spray-dried granule Can be generated using one or more of When choosing the process to use, it is important to consider the physicochemical properties of the active ingredients and additives. GA Bell and DA Knowles in, “Chemistry and Technology of Agrochemical Formulations”, DA Knowles, (Kluwer Academic Publishers, 1998), pages 41-114, describes the types of granules used in agrochemical formulations, There is a lot of literature on the production of these solid formulations.

  In addition to the compositions and uses described above, the described compositions can be used in combination with one or more other pesticides to control a wider variety of undesirable pests. Also included are pesticide granule compositions and uses. When used in combination with other pesticides, currently claimed pesticide granules may be formulated with other pesticide (s) or pesticide (s), etc. Can be tank mixed with other pesticide (s) or pesticide (s), or sequentially applied with other pesticide (s) or pesticide (s). In addition, the pesticide granules optionally contain, for example, a physically uniform blend of granules by combining or blending with other pesticide granule compositions containing additional active ingredients. A composition can be formed. This blend of pesticide granules can be used to control unwanted weeds and other pests in crop and non-crop environments.

  In addition to the compositions and uses described above, the described compositions also encompass the compositions and uses of these pesticide granules in combination with one or more additional compatible ingredients. Other additional compatible ingredients include, for example, one or more agrochemical active ingredients, adjuvants, fertilizers, growth regulators and pheromones, and, for example, surfactants, dyes, stabilizers, fragrances and dispersants Any other additional ingredients that provide functional utility may be mentioned.

  The herbicidal granules of the described composition additionally provide undesirable vegetation in many crops that have been made resistant or resistant to undesirable vegetation or other herbicides by genetic engineering or by mutation and selection. Can be used to control. The herbicidal granule of the present invention is further used in combination with glyphosate, glufosinate, dicamba, imidazolinone or 2,4-D to have glyphosate resistance, glufosinate resistance, dicamba resistance, imidazolino resistance or 2,4-D resistance. Can be used on crops. It is generally preferred to use the herbicidal granules of the present invention in combination with a herbicide that is selective for the crop to be treated and supplements the spectrum of weeds controlled by the herbicidal granules at the applied dose used. It is more generally preferred to apply the herbicidal granules of the present invention and other complementary herbicides simultaneously, either as a combination formulation or tank mix. Similarly, the herbicidal granules of the present invention can be used on acetolactate synthase inhibitor resistant crops in combination with an acetolactate synthase inhibitor.

  The described embodiments and the following examples are for illustrative purposes and are not intended to limit the scope of the claims. Other variations, uses, or combinations of the compositions described herein will be apparent to those skilled in the art without departing from the spirit and scope of the claimed subject matter.

Example 1
Preparation of Granules with Improved Dispersion Properties in Water Containing Highly Filled Fluroxypyrmeptyl Highly Filled Stable Fluroxypyrmeptyl Dry Powder Formulation is Microencapsulated as Described herein An oil-in-water emulsion was prepared by spray drying. 3.440 g of polyisocyanate (PAPI® 27; The Dow Chemical Company, Midland, MI) is dissolved at 70 ° C. in 67.303 g of molten industrial fluroxypyrmeptyl (melting point: about 58 ° C.) To prepare an oily phase of an oil-in-water emulsion. 17.301 g of a 20 wt% aqueous solution of polyvinyl alcohol (PVA; Celvol® 205; Sekisui Specialty Chemicals LLC, Dallas, TX), and an alkylated polyglucoside (APG) solution (Agnique® PG9116Cincin The aqueous phase of the oil-in-water emulsion was prepared by dissolving 3.042 g of a 50 wt% solution of OH) in 70.46 g of deionized (DI) water. While slowly adding the oil phase into the aqueous phase, mixing at approximately 3000 rpm to 5000 rpm for 5-10 minutes using a Silverson high shear mixer, the volume average mean diameter (d (0.5 A fine emulsion having suspended oil droplets with)) was produced. The aqueous emulsion contains 50.161 wt% water, 2.278 wt% PVA, 1.001 wt% APG, 44.300 wt% industrial fluroxypyr, and 2.262 wt% PAPI 27. When the desired emulsion size was obtained, 2.736 g of a 30 wt% aqueous solution of ethylenediamine was added dropwise into the mixture over a period of about 2-3 minutes. The mixture was then continued to mix with Silverson at 70 ° C. for about 1 hour to form microcapsules with a capsule wall thickness of about 25 nm. The microencapsulated oil droplets were further stabilized by adding 39.744 g of an additional 20 wt% aqueous Celvol® 205 PVA to the microcapsule suspension. 50 wt% APG (Agnique® PG9116) 0.380 g aqueous solution, Pergopak® M (Albemarle Corp., Baton Rouge, LA) 5.704 g, Polyfone® F (Meadwestvaco, Richmond, Vichmon, Richmond) ) 9.612 g and 233.607 g of DI water were added to the microcapsule suspension. The final aqueous microcapsule suspension containing 22.5 wt% solids in water and held at 70 ° C. was fed into a spray dryer (BUCHI 290) at a feed rate of 300 ml / hr and about 135 ° C./80° C. respectively. At the inlet / outlet temperature. The resulting dry powder (Powder A), when redispersed in water, had a volume median diameter (d (0.5)) of 4.8 microns (μm). A moisture level of about 25 wt% was achieved in the wet powder by uniformly mixing Powder A (15 g) with 10.16 g of 37.5 wt% saturated aqueous ammonium sulfate (AMS) binder solution. The wet powder was extruded using a Fitzpatrick basket extruder (model number KAR-75) to produce two batches of wet granules using 0.8 mm and 1 mm screens. The wet granules were dried in an oven at 30 ° C to 50 ° C. Dry granules (granule A) typically contain about 3 wt% residual water. According to a procedure similar to that described above, a second sample of extruded granules (Granule B) was prepared using water alone as the binder. The composition of the granules is compared in Table 1. Table 2 summarizes the size range of the particles produced from the dried granules upon dispersion in water. Table 3 shows a comparison of the dispersion times of extruded granules prepared using water alone as a binder or an AMS solution as a binder. Extruded granules (both 0.8 and 1.0 mm size) prepared with an AMS solution as a binder disperse rapidly when diluted in water (<120 seconds) at ambient temperature or 5 ° C. and> 24 in water. Redispersion over time also provides excellent stability of active ingredient crystal growth.

Example 2
Use of Granules of the Invention for Weed Control Post-emergence greenhouse trial method: Peat-based potting soil, Metro-mix 360 (produced by Sun Gro Horticultural Canada CM Ltd), used as soil medium for this test did. Metro-mix 360 is a growth medium consisting of Canadian sphagnum moss, coarse perlite, bark ash, starter nutrient input (using gypsum) and slow release nitrogen, and dolomite limestone. The exact proportion is exclusive. Several seeds of various types were planted in a 10 cm square pot and watered from above twice a day. Plant material was propagated in greenhouse zone E2 at a constant temperature of 18 ° C. to 20 ° C. and a relative humidity of 50% to 60%. Natural light was supplemented with an average illumination of 500 microeinsteins per second (μEm ⁻² s ⁻¹ ) per square meter of photosynthetic active radiation (PAR) using a 1000 watt metal halide overhead lamp. The day length was 16 hours. The plant material was watered from above before treatment and irrigated from below after treatment. Processed using a track sprayer manufactured by Allen Machine Works and located in building 306, room E1-483. The sprayer delivered 187 L / Ha utilizing an 8003E spray nozzle, a spray pressure of 262 kPa pressure, and a speed of 2.0 mph. The nozzle height was 46 cm above the plant crown. The growth stages of various weed species range from 2 to 6 leaves, and listed below by species, the dosages are 0 g ae / ha, 8.8 g ae / ha, 17.5 g ae / ha, 35 g ae / ha, 70 g ae / ha and 140 g ae / ha. The treatment was repeated 3 times. Plants were returned to the greenhouse after treatment and watered from below throughout the duration of the experiment. The plant material was fertilized twice weekly with Hoagland's fertilizer solution, which is readily available in the greenhouse. The determination of percent visual damage was made on a scale of 0% to 100% when compared to an untreated control plant (where 0 equals no damage and 100 equals complete death of the plant. The completed plants are listed in Table 4. The results are summarized in Table 5.

Claims (20)

(Viii) providing a powder comprising a pesticide active ingredient;
(Ix) adding water to the powder;
A method for improving the dispersion characteristics of a pesticide-containing granule in water, comprising (x) blending the powder and water into a mixture, and (xi) processing the mixture into granules. The method is characterized by mixing one or more water-soluble aggregation inhibitors in the powder or water prior to blending, wherein the amount of the one or more aggregation inhibitors is at least step (b) A process that is the amount required to achieve 50% of the saturation concentration in the amount of water added in. Pesticide active ingredient
(A) 2,4-D, 2,4-DB, aminocyclopyrchlor, aminopyralide, bromoxynyl, chlorsulfuron, cretodim, clodinapop, clopyralid, cyhalohop, dicamba, phenoxaprop, florasulam, fluazihop, fluazihop-P, Fluroxypyr, glufosinate, glyphosate, haloxyhop, haloxyhop-R, imazamox, imazapic, iodosulfuron, ioxynil, MCPA, mesosulfuron, mesotrione, metamihop, metoslam, metsulfuron, penoxthram, picloram, pinoxaden, proploxapone, propoxylamp Quizalofop, cetoxydim, thifensulfuron-methyl, tribenuron or triclopyr, or their esters Ether or salt or, (b) formula I

Or a C ₁ -C ₆ alkyl ester or salt thereof,
Or formula II

Compound, or a _C 1 _{-C 12} alkyl ester or _C 7 _{-C 12} arylalkyl esters or salts The method of claim 1.   The method of claim 1 wherein the pesticidal active ingredient is fluroxypyrmeptyl.   The method of claim 1, wherein the one or more water-soluble aggregation inhibitors are inorganic acid salts, organic acid salts, or carbohydrates.   2. The method of claim 1, wherein the one or more water-soluble aggregation inhibitors are alkali metal salts, alkaline earth metal salts, ammonium salts, sulfates, nitrates or citrates.   The method according to claim 1, wherein the aggregation inhibitor is magnesium sulfate, ammonium sulfate, or ammonium nitrate.   The amount of one or more aggregation inhibitors is the amount required to achieve at least 70% of the saturation concentration in the amount of water added in step (b). Method.   The method of claim 1 wherein the processing in step (d) is performed by utilizing a high shear granulation process.   The method of claim 8, wherein the high shear granulation process is an extrusion process. a. The pesticide active ingredient is fluroxypyrmeptyl,
b. The one or more water-soluble aggregation inhibitors are alkali metal salts, alkaline earth metal salts, ammonium salts, sulfates, nitrates or citrates;
c. The processing in step (d) is performed by utilizing a high shear granulation process;
The method of claim 1. (I) adding water to the powder,
a. The powder comprises a pesticidal active ingredient,
b. One or more water-soluble aggregation inhibitors are incorporated into one of the water or powder, wherein the amount of the water-soluble aggregation inhibitor incorporated is at least a saturation concentration in the amount of water added. A step that is the amount needed to achieve 50% of the
A method of producing pesticide-containing granules comprising (ii) blending the powder and water into a mixture, and (iii) processing the mixture into granules.   12. The method of claim 11, wherein the pesticidal active ingredient is fluroxypyrmeptyl. a. The aggregation inhibitor is magnesium sulfate, ammonium sulfate or ammonium nitrate;
b. The amount of the one or more aggregation inhibitors is the amount required to achieve at least 70% of the saturation concentration in the amount of water added in step (b);
c. The processing in step (iii) is performed by utilizing a high shear granulation process;
The method of claim 12. a) about 10 grams per kilogram (gai / kg) to about 900 gai / kg of pesticide active ingredient relative to the total composition;
b) about 20 grams per kilogram (g / kg) to about 900 g / kg per kilogram of total composition, and c) solid anionic surfactant and solid based on total composition About 10 g / kg to about 300 g / kg of at least one nonionic surfactant
Pesticide-containing granules having improved dispersion properties in water, including.   The granule according to claim 14, wherein the granule comprises at least 200 g / kg of a water-soluble aggregation inhibitor.   15. The granule of claim 14, wherein the granule comprises at least about 60 g / kg of at least one of a solid anionic surfactant and a solid nonionic surfactant.   15. Granule according to claim 14, wherein the pesticidal active ingredient is fluroxypyrmeptyl. Pesticide active ingredient
(A) 2,4-D, 2,4-DB, aminocyclopyrchlor, aminopyralide, bromoxynyl, chlorsulfuron, cretodim, clodinapop, clopyralid, cyhalohop, dicamba, phenoxaprop, florasulam, fluazihop, fluazihop-P, Fluroxypyr, glufosinate, glyphosate, haloxyhop, haloxyhop-R, imazamox, imazapic, iodosulfuron, ioxynil, MCPA, mesosulfuron, mesotrione, metamihop, metoslam, metsulfuron, penoxthram, picloram, pinoxaden, proploxapone, propoxylamp Quizalofop, cetoxydim, thifensulfuron-methyl, tribenuron, or triclopyr, or their Ester or salt, or, (b) formula I

Or a C ₁ -C ₆ alkyl ester or salt thereof,
Or formula II

Compound, or a _C 1 _{-C 12} alkyl ester or _C 7 _{-C 12} arylalkyl esters or salts, granules according to claim 14.   The granule according to claim 14, wherein at least one of the solid anionic surfactant and the solid nonionic surfactant is lignosulfonate, alkylnaphthalenesulfonate formaldehyde condensate, polyvinyl alcohol, or alkylpolyglycoside. a. The granules comprise at least 200 g / kg of a water-soluble aggregation inhibitor;
b. The granules comprise at least about 60 g / kg of at least one of a solid anionic surfactant and a solid nonionic surfactant;
c. The pesticide active ingredient is fluroxypyrmeptyl,
d. At least one of the solid anionic surfactant and the solid nonionic surfactant is lignosulfonate, alkylnaphthalenesulfonate formaldehyde condensate, polyvinyl alcohol, or alkylpolyglycoside,
The granule according to claim 14.