JP2014522839A - Particle aerosolization - Google Patents

Abstract

  A composition comprising caffeine; a vitamin; and a sweetener.

Description

  The present invention generally relates to aerosolized products and devices for the storage, aerosolization and / or delivery of the products.

  Previous investigators have shown that aerosol particles can be used to deliver substances to various parts of the body. Specific designs have been proposed for using these particles for drug delivery.

  When inhaling particles that are light enough to enter through the mouth, especially if the purpose is to provide taste and / or nutrition using the mouth, tongue, etc., the particles are deep in the mouth. Or they must address the risk of reaching the lungs and causing cough or other adverse events.

  Accordingly, approaches to delivering substances to the mouth by air route have focused primarily on directed non-respiratory delivery (if not exclusive). In that case, the force and particle size of the air flow is such that the trajectory of the particles is mainly restricted to the mouth.

  The inventors have developed approaches where natural breathing or forced breathing behavior (such as normal inhalation) can result in the delivery of food, beverages and / or various other particles to the mouth. This approach limits the transport of these particles to the back of the throat and lungs by airflow. By controlling the inertia and gravity of the particles and by directing the direction of the deposition force, we concentrate the delivery of the particles towards the mouth surface so that they do not reach the back of the throat and the lungs. Made it possible to

The present inventors have the following two practical aspects.
1. The particle size is very important for our delivery system. That is, the particles must be small enough to remain suspended in the air during natural breathing, but large enough to be deposited primarily in the mouth while limiting throat and lung deposition There is.
2. At the same time, the typical path of aerosol particles exiting the mouthpiece through the device is directed at various angles away from the back of the throat.

  By combining the appropriate particle size and the air path directed by the device, the particles will be deposited primarily in the mouth (and on the tongue, palate, etc.) rather than in the back of the throat or even in the respiratory tract. become.

  In one embodiment, the composition comprises caffeine, vitamins, sweeteners and sodium bicarbonate; the average particle size of the composition is greater than 10 microns and less than 500 microns.

  In one embodiment, the composition comprises caffeine; vitamins; and sweeteners, wherein the average particle size of the composition is 18-70 microns.

  Embodiments of these aspects can include one or more of the following features.

  In some embodiments, the composition also includes citric acid. In some examples, the composition contains more citric acid than sodium bicarbonate, and in particular, the weight ratio of citric acid to sodium bicarbonate is 45 to 38 to 1: 1.

  In some embodiments, the sweetener comprises thaumatin and stevia. In some examples, the weight ratio of thaumatin to stevia is 11 to 4 to 9 to 6. In some examples, the weight ratio of caffeine to the combined thaumatin and stevia is 25: 2 to 90:17.

  In some embodiments, the composition also includes a flavoring agent, particularly a natural flavoring agent.

  In some embodiments, the composition also includes a mineral supplement, in particular the vitamin comprises at least one of niacin, pyridoxine and cyanocobalamin.

  In some embodiments, the average particle size of the composition is 18-70 microns.

  In one embodiment, the delivery device is a reservoir containing an aerosol generating device; and a consumable material comprising caffeine; vitamins; and sweeteners, the aerosol generating device for transferring the consumable material to the aerosol generating device. And a reservoir connected to the device.

  Embodiments of these aspects can include one or more of the following features.

  In some embodiments, the consumable material further comprises sodium bicarbonate and citric acid, and in particular the composition contains more citric acid than sodium bicarbonate, more specifically citric acid and The weight ratio of sodium bicarbonate is 45 to 38 to 1: 1.

  In some embodiments, the sweetener comprises thaumatin and stevia, in particular, the weight ratio of thaumatin and stevia is 11: 4-9: 6. In some examples, the weight ratio of caffeine to the combined thaumatin and stevia is 25: 2 to 90:17.

  In some embodiments, the consumable material further comprises a flavoring agent, particularly a natural flavoring agent.

  In some embodiments, the consumable further comprises a mineral supplement, and in particular the vitamin comprises at least one of niacin, pyridoxine and cyanocobalamin.

  In some embodiments, the consumable material has an average particle size of 18-70 microns.

  In one aspect, the particle delivery device comprises an aerosol delivery device (which may also be an aerosol generating device) for releasing an aerosolized product along a substantially vertical axis, and a container attached to the aerosol delivery device. Prepare. The container is a primary chamber, a vertical axis along which the delivery device emits particles extends into the primary chamber, and at least a first size of particles rises along the substantially vertical axis. A primary chamber hydraulically connected to the aerosol delivery device so as to have a tendency to descend, and adjacent to the primary chamber, open to the primary chamber and / or in communication with the primary chamber. The next chamber is defined. The secondary chamber extends horizontally outward from the primary chamber such that particles smaller than the first size have a tendency to disperse from the primary chamber to the secondary chamber, the secondary chamber being an outlet spaced from the primary chamber Have

  Embodiments can include one or more of the following features, alone or in combination.

  In some embodiments, the aerosol delivery device comprises a fluid reservoir with an ultrasound generator. In some embodiments, the aerosol delivery device comprises a piezoelectric element. In some examples, the free surface of the fluid in the fluid reservoir is exposed to the primary chamber of the container.

  In some embodiments, the lower surface of the secondary chamber is angled so that liquid that lands on the lower surface of the secondary chamber has a tendency to flow toward the fluid reservoir.

  The surface of the primary chamber can include a surface that extends across the substantially vertical axis so as to limit the movement of particles moving along the substantially vertical axis.

  The apparatus can be a tabletop unit or an independent unit with a base configured to stably support the container on a support surface.

  The container may define an opening extending through the container into an internal cavity, the opening being offset vertically from the aerosol delivery device when the delivery device is positioned for operation. In some examples, the container defines, from above, an opening that is open to and / or in communication with the secondary chamber. In some examples, the container comprises a closable outlet disposed on a side surface of the container.

  In some embodiments, the closable side outlet may comprise an opening and a cap biased to close the opening. In some examples, the device comprises an elastic member arranged to bias the cap to cover the opening. In some examples, the weight of the cap biases the cap to cover the opening.

  In one aspect, the delivery device comprises an aerosol delivery device for releasing an aerosolized product. The aerosol delivery device includes a mouthpiece defining a first fluid flow path extending between a mouthpiece inlet and a mouthpiece outlet, and a deflection member spaced from the plane of the mouthpiece outlet, the deflection member being a mouse A deflecting member, a capsule containing an aerosolizable product, arranged to face the flow of aerosolized product along the axis of the piece outlet, the capsule comprising a capsule inlet and a capsule outlet A second fluid flow path extending between the mouthpiece and the capsule substantially seals the capsule outlet in the first position of the mouthpiece and the capsule outlet in the second position of the mouthpiece. A capsule and at least one intake channel attached to the mouthpiece such that the fluid is fluidly connected to the mouthpiece inlet An end cap defining, wherein the intake passage extends through the end cap, the end cap substantially sealing the capsule inlet in the first position of the end cap; An end cap attached to the capsule such that the capsule inlet is fluidly connected to the intake passage of the end cap in the second position of the cap.

  Embodiments can include one or more of the following features, alone or in combination.

  In some embodiments, the capsule comprises an aerosol generating device. In some examples, the aerosol generating device comprises a grid.

  In some embodiments, the capsule is configured to be replaceable.

  In some embodiments, the device is configured to be used multiple times.

  In some embodiments, the device is configured to provide a permanent attachment of the end cap and mouthpiece to the capsule.

  In some embodiments, the device is handheld.

  In one aspect, the present disclosure is of a size that is primarily large enough to deposit in the mouth and small enough to allow levitation in the air, with limited access to the respiratory tract. It relates to the delivery of aerosolized particles. In another aspect, the disclosure provides a product, an aerosol generating device that causes aerosolization of the product, and a delivery device that delivers the aerosolized product in a manner suitable for inhalation or deposition and subsequent ingestion. The present invention relates to a device incorporating the above. In another aspect, the present disclosure relates to an airflow directing element in an apparatus or device for delivering a product by aerosol. These elements control the gravity, inertia, and other forces associated with the aerosol cloud as it is delivered into the mouth, thereby substantially deflecting the aerosol cloud toward the mouth surface, However, it reduces the extent to which it can continue to progress into the throat and even into the respiratory tract.

  Our device provides a novel means for delivering particles to human and animal mouths. In fact, the device is large enough to be deposited in the mouth and substantially small enough to allow levitation in the air without substantially exposing or entering the respiratory tract. Designed to produce aerosolized particles that are sized.

  In some embodiments, our devices are different from conventional mechanical delivery means, i.e. the use of instruments, and conventional mechanical food digestion means, i.e. by chewing or inhaling, Inhalation, body movement, and / or aerosol movement or a combination thereof generates an aerosol cloud of particles that enter the mouth of a human or animal. For example, simple inhalation can function to deposit particles in the digestive tract, including the subject's mouth.

  Alternatively, or in combination, the subject can simply walk, tilt, etc., so that the subject's mouth is exposed to particles, resulting in deposition in the mouth. It may physically expose itself to particles released from the device by physical movement. Alternatively or in combination, the subject may have an air stream carrying the aerosol or a user carrying the aerosol so that the subject's mouth is exposed to particles resulting in deposition in the mouth. It may be physically exposed to particles released from the device by simple aerosol motion, such as release from a container.

  Our device generally comprises a product and an aerosol generating device. In some embodiments, the device comprises a product, an aerosol generating device, and an intake passage. In some embodiments, the device comprises a mouthpiece. In some embodiments, the device consists only of a mouthpiece. The device can be actuated by inhalation in the mouthpiece to cause exposure of the product to an aerosol generating device and subsequent aerosolization of the product. The inhalation further functions to deliver an aerosolized product into the subject's mouth.

  In some embodiments, the device comprises a product, an aerosol generating device, and a force generating device, such as an air pump. The device can be actuated by a force generator to cause exposure of the product to an aerosol generating device, followed by aerosolization of the product, and release of those products from the device.

  In some embodiments, the device comprises a product and an aerosol generating device, such as an ultrasound source. The device can be operated by an aerosol generating device. The aerosol generating device may atomize and / or aerosolize the product and release the product from the device.

  In some embodiments, the device may incorporate a delivery device.

  The delivery device can generate an aerosol cloud of edible material by sonication of the liquid. These clouds can be inhaled for ingestion, avoiding the respiratory tract, if the particle size is sufficiently large and the clouds are inhaled.

  Ingestible aerosol clouds can be generated by sonication and / or other means that avoid these problems and provide many benefits to the inhalation feeding experience. In some embodiments, the delivery device allows large particles to rise and fall over the source, while smaller particles can be used, particularly when the lateral movement of the cloud can occur very close to the surface of the liquid. The aerosol cloud is displaced laterally with respect to the source of the aerosol cloud so that it separates from the falling large droplet and moves laterally by diffusion and convection.

  Large and medium droplets drop by gravity in the lateral direction due to convection, and therefore, if a side chamber is provided to accommodate the clouds, the fine droplets that become stable standing clouds A cloud of aerosol particles can be formed. This cloud can be designed to have particles in the desired oral delivery range by manipulating the properties of the liquid, including the size of the cloud container and the surface tension of the liquid. It should be noted that a surface tension lower than about 73 dynes / cm that produces an excellent standing cloud aerosol can be achieved by the use of a surfactant. In addition, an opening or spout can be provided by which the cloud can be poured into a glass or other container, which is a convenient and useful way of eating material by inhalation.

  The advantages of the present disclosure described below, as well as further advantages of the present disclosure, may be better understood by referring to this description in conjunction with the accompanying drawings.

1 is a schematic view of an embodiment of a delivery device before use. 1 is a schematic diagram of an embodiment of a delivery device in use. FIG. FIG. 3 is a perspective view of a delivery device. FIG. 3 is a perspective view of a delivery device. 2B is an exploded perspective view of the delivery device of FIGS. 2A and 2B. FIG. FIG. 3 is a cutaway perspective view of the delivery device of FIGS. 2A and 2B. FIG. 3 is a cutaway perspective view of the delivery device of FIGS. 2A and 2B. 2C is a cross-sectional view of the delivery device of FIGS. 2A and 2B. FIG. 2C is a cross-sectional view of a portion of the delivery device of FIGS. 2A and 2B. FIG. 1 is a schematic diagram of a specific embodiment of a delivery device and a flow diagram for its use and operation. FIG. 6 is a multi-sided view of an exemplary embodiment of a mouthpiece 112. FIG. 6 is a multi-sided view of an exemplary embodiment of an end cap 114. FIG. 6 is a multi-sided view of an exemplary embodiment of a capsule 116. Schematic of the delivery device before use. FIG. 2 is a schematic view of a delivery device in use. Photograph of aerosolization and release of dehydrated mint particles using a manual aerosol generator. FIG. 3 is a perspective view of a delivery device. FIG. 3 is a top view of a delivery device. FIG. 3 is a side view of a delivery device. The bottom view of a delivery device. The perspective view of an aerosol production | generation apparatus. The top view of an aerosol production | generation apparatus. The side view of an aerosol production | generation apparatus. The end view of an aerosol production | generation apparatus. Pictures of the delivery device at different stages of use. FIG. 3 is a perspective view of a delivery device. FIG. 3 is a top view of a delivery device. The front view of a delivery device. FIG. 4 is a rear view of the delivery device. The left view of a delivery device. The right view of a delivery apparatus. The bottom view of a delivery device. Pictures of the delivery device at different stages of use. A picture of the delivery device in use. Graph from HELOS-RODOS particle size analysis of dried, crushed and sieved mint leaves. A picture of the delivery device. The delivery device comprises a housing, a mouthpiece formed in the housing, an air flow directing element attached to the mouthpiece by a bridge, a capsule having an air passage and a lattice, an air passage, and a capsule And a cap that can engage with both the housing. In some embodiments, the lattice, here part of the capsule, functions as an aerosol generating device. A picture of the delivery device. The delivery device includes a housing, a mouthpiece formed in the housing, an air flow directing element attached to the mouthpiece by a bridge, a capsule having an air passage and a lattice, an air passage, and the capsule and A cap that can be fitted to both sides of the housing. In some embodiments, the lattice, here part of the capsule, functions as an aerosol generating device. FIG. 4 shows the specifications of a particular embodiment of a delivery device. The delivery device includes a housing, a mouthpiece formed in the housing, an air flow directing element attached to the mouthpiece by a bridge, a capsule having an air passage and a lattice, an air passage, and the capsule and A cap that can be fitted to both sides of the housing. FIG. 3 is a perspective view of an embodiment of a delivery device. FIG. 3 is a cross-sectional view of an embodiment of a delivery device. FIG. 19 is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 19A and 19B. FIG. 19 is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 19A and 19B. FIG. 19 is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 19A and 19B. Detailed view of various portions of the embodiment of the delivery device shown in FIGS. 19A and 19B FIG. 19 is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 19A and 19B. Detailed view of various portions of the embodiment of the delivery device shown in FIGS. 19A and 19B FIG. 19 is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 19A and 19B. FIG. 19 is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 19A and 19B. FIG. 19 is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 19A and 19B. FIG. 19 is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 19A and 19B. 1 is a perspective view of an embodiment of a delivery device in a closed position. FIG. 1 is a perspective view of an embodiment of a delivery device in an open position. FIG. 20B is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 20A and 20B. FIG. 20B is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 20A and 20B. FIG. 20B is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 20A and 20B. FIG. 20B is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 20A and 20B. FIG. 20B is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 20A and 20B. FIG. 20B is a detailed view of various portions of the embodiment of the delivery device shown in FIGS. 20A and 20B. FIG. FIG. 21 is a detailed view of different portions of the embodiment of the delivery device shown in FIGS. 20A and 20B.

  Our approach is based at least in part on the realization of new forms of food products and methods and apparatus for delivering those food products. More specifically, delivery techniques and techniques relate to aerosolized products and delivery methods and devices designed to generate and deliver such products to a subject. Such devices can deliver food substances into the mouth by aerosol. Here, the aerosol cloud is generated by natural inspiration and delivered to the mouth. The mouthpiece of the device is designed so that suspended particles can be diverted from the back of the throat to limit entry into the respiratory system.

  With reference to FIGS. 1A and 1B, the delivery device 50 comprises an aerosol generating device. In an aerosol generating device, inhalation induces aerosolization of the product 52 and subsequent delivery of the aerosolized product to the subject's mouth. The delivery device 50 includes a compartment 54 containing a product 52 (eg, powdered food). The compartment 54 has an intake passage 56 and is connected to a mouthpiece 58. The intake passage 56, the compartment 54, and the mouthpiece 58 are such that the air flow generated by inhalation aerosolizes the product 52, and the aerosolized product is passed from the compartment 54 through the mouthpiece 58 to the mouth of the consumer. Allows the passage of air to be transported to.

  With reference to FIGS. 2A-2F, delivery device 100 includes a housing 110 having a mouthpiece 112 and a removable end cap 114. The delivery device 100 is sized so that a user can easily hold the device with one hand when generating and delivering an aerosolized product using the device 100. The airflow directing or deflecting member 118 is disposed at one end of the mouthpiece 112 by a bridge 120. The bridge 120 arranges the air flow directing member 118 at a position away from the plane of the outlet 122 of the mouthpiece 112. The end cap 114 is attached to the end of the mouthpiece 112 and on the end opposite to the air flow directing member 118.

  As seen in FIG. 2D, the mouthpiece 112 defines a fluid flow path that extends from the inlet 124 to the outlet 122 of the mouthpiece 112. The end cap 114 has an air passage 126 extending from one surface of the end cap 114 to the opposite surface of the end cap 114. When the end cap 114 is attached to the mouthpiece 112 at the inlet end of the mouthpiece 112, both the mouthpiece 112 and the end cap 114 define a flow path through the housing 110. Thus, when a user inhales with the mouthpiece 112 outlet 122 in his mouth, the air passes through the end cap 114 to the mouthpiece 112 inlet 124 and through the mouthpiece 112 to the mouthpiece 112 outlet. It flows to 122. Due to the contact with the air flow directing member 118, the air flowing out of the mouthpiece 112 is deflected.

  In some embodiments, the airflow directing element and / or deflecting member may be of various configurations (not necessarily discs) to exit the mouthpiece and divert the airflow entering the mouth from a straight trajectory towards the throat and lungs. Any of the above may be used. For example, there may be one or more openings near the top of the mouthpiece, which may be biased relative to each other at different heights, at different sizes, in different areas, etc. Often, the overall obstruction of the direct straight path to the back of the mouth is maintained, and the air flow and aerosol are generally diverted to travel more laterally.

  In some embodiments, the airflow directing element is a thin disc having a flat surface that is generally orthogonal to the mouthpiece axis and that opposes the direction of overall airflow in the mouthpiece. In some examples, the disc may be attached to the mouthpiece by one or more “bridges”. The bridge, for example, holds the disc slightly above, below or at the same height as the mouthpiece end, allowing air and aerosolized product to pass around the disc. In various embodiments, the disc may have a diameter that is smaller than the opening of the mouthpiece, equal to the opening, or larger than the opening. In addition, the disk may be of any desired shape, for example oval or circular. The airflow directing element restricts aerosol flow to the throat that can induce a cough reflex by redirecting the aerosol to the side of the mouth (eg, the top, bottom, left, or right side of the mouth). Instead, aerosolized products are deposited on other parts of the tongue or mouth where they can be sensed and recognized, rather than being carried deeper into the respiratory tract. In some embodiments, the airflow directing elements are of different shapes, sizes and / or designs, but the aerosolized product is used to limit the cough reflex and / or enhance the taste experience. It works in the same way to turn around. By testing various disc sizes and positions, it was shown that these two parameters can affect the likelihood of coughing. For example, in a preliminary test, a disc whose diameter is approximately equal to the outer diameter of the mouthpiece and which is placed close to the mouthpiece has a diameter approximately equal to (and therefore smaller than) the inner diameter of the mouthpiece; And it has been found that it is generally more effective in aerosol redirection and cough restriction than a disc located at a greater distance from the mouthpiece (leaving more space for the aerosol to pass through).

  In this embodiment, the end cap 114 is formed from an elastic material. The first end 128 of the end cap 114 has an outer surface that is sized and configured to provide a snap-fit engagement with the inner surface of the corresponding end of the mouthpiece 112. In some embodiments, other forms of engagement are used to attach the end cap 114 to the mouthpiece 112 instead of or in addition to the snap-fit engagement. For example, in some embodiments, the end cap 114 and the mouthpiece 112 are threaded and threaded together.

  The end cap 114 defines an internal cavity that is sized to receive a capsule 116, such as a capsule 116 containing a mouthpiece 112 (ie, a housing), eg, a powder product (not shown). Capsule 116 is configured to provide fluid communication between the contents of capsule 116, such as a powder product and a mouthpiece, or otherwise in fluid communication therebetween. Has been. In this embodiment, the capsule 116 has an open end 130 and an opposite aerosol generating end 132. The open end 130 of the capsule 116 fits within the first end 128 of the end cap 114 and is sized to provide a snap fit engagement with the inner surface of the first end 128 of the end cap 114. And configured as such. In some embodiments, the capsule may be fitted into a housing or screwed. In some embodiments, the capsule comprises an open end that can be covered by a cap (in certain embodiments only at certain times), for example by fitting or screwing. In some embodiments, the inlet end of the capsule is not open but defines a vent path.

  Referring to FIG. 2F, in some embodiments, the capsule 116 fits into the cap 114 with a full-length snap mechanism against the inside of the cap 114, and the cap 114 fits into the mouthpiece 112 with an intermittent snap mechanism. The device may typically be designed such that it is more difficult to separate the cap 114 from the capsule 116 than to separate the cap 114 and / or capsule 116 from the mouthpiece 112. Thus, the user can easily remove the capsule 116 and / or cap 114 by removing the capsule 116 and / or cap 114 from the mouthpiece 112 with minimal risk of accidental removal of the capsule 116 from the cap 114. Can be replaced.

  Some embodiments may be further improved by incorporating snap mechanisms that facilitate device use and functionality. For example, the device may incorporate a snap mechanism to facilitate the use of mechanisms such as those described above that allow the air passage to be opened and closed. For example, the mouthpiece so that the mouthpiece and capsule can be connected by one (or more) snap mechanism and the capsule and cap can be connected by two (or more) snap mechanisms. And capsules can be designed. For example, the mouthpiece may be connected to the capsule by one relatively weak snap interface, and the capsule may be connected to the cap by two relatively strong snap interfaces. In some embodiments, these snap mechanisms may (1) hold the capsule (or more generally one end of the food storage device) to the mouthpiece (or more generally the delivery device). Can ("snap A"), (2) capsules and caps (or more generally together with the components of the food storage equipment), powder loss (especially related during shipping, handling, etc.) And can be kept in an initial “closed” configuration that can function to provide a sealed or near-tight environment for product storage prior to use (“Snap B” )), (3) After user intervention, the capsule and cap (or generally a component of the food-containing device) can be reconnected so that air can flow through the device, followed by aerosolization of the product Allowing it to maintain a new "open" configuration ( "Snap C").

  The force required to actuate each of these snaps is related to the functionality and ease of use of the device. They can be configured to allow use as follows: (1) The user attaches a capsule / cap component to the mouthpiece. Snap A is activated. Here, the capsule is hidden in the mouthpiece and cap. (2) The user now pulls the cap and removes the snap B. Due to the strong snap A, the capsule remains connected to the mouthpiece and the cap slides away from the mouthpiece. As previously mentioned, this relative movement between the capsule and the cap allows the air passage to open. (3) The user continues to pull the cap back until the snap C is activated and locks the capsule and cap in place so that the air passage remains open. The user can now inhale and the product can be aerosolized and delivered into the mouth. When the product is consumed, the high strength of this snap (C) allows the user to pull the capsule / cap from the mouthpiece and replace it with a new capsule / cap, while minimizing the risk of separating the capsule from the cap instead. (Capsule is simultaneously connected to the mouthpiece by Snap A and to the cap by Snap C; since Snap C is designed to be stronger than Snap A) The force applied by the user to pull the mouthpiece and cap in the opposite direction generally removes the capsule and cap as a unit from the mouthpiece, thus releasing the snap A). In some embodiments, Snap C is also important in that it minimizes the user's chance of completely separating the capsule and cap after the mouthpiece has been removed. In some cases, it may be desirable to prevent a user from trying to add his product or otherwise trying to modify the product or food compartment.

  In many cases, variations of some embodiments may be designed in many cases without affecting the overall functionality of the device. For example, the cylindrical nature of the device may be altered, for example, for aesthetic effects, and so on over the entire length of the device. Alternatively or in addition, an aerosol generating device, for example an air flow disturbing element such as a grid, may be incorporated into the cylindrical mouthpiece. In some embodiments, the aerosol generating device may comprise more than one component. For example, the cap grid and / or air flow passage may play an individual role in the generation of turbulence resulting in aerosolization, or both may be required. In general, there can be many configurations for grids, airflow passages, dimensions, etc. to generate the correct aerosolized airflow.

  In some embodiments, the size of the device is such that standard medical capsules can be used directly as compartments while maintaining adequate airflow dynamics, or the capsules and / or caps described above. It can be chosen so that it can be exchanged to some extent or, alternatively, can simplify the powder filling, storage and release process.

  In some embodiments, the capsule and / or cap has a concave interior space, and after either or both of them are filled with powder, the two units fit or screw. Together, it forms a substantially closed inner chamber. The capsule or another component of the device should further comprise an aerosol generating device, such as an air flow perturbation “grid”, through which air and powder flow to produce an aerosol for delivery to the user. The cap and / or capsule should be provided with an air passage at each end of the closed compartment, for example, so that air can pass by inhalation. The design of the air passage, such as size or shape, should provide sufficient air flow while minimizing powder loss.

  In some embodiments, cap 114 and / or capsule 116 are designed to minimize powder loss. For example, as seen in FIG. 1E, the air passage is not straight to the bottom but at an angle to the side so as to limit the powder from falling by gravity even when the device is held upright. I am doing. If the powder is inside the capsule / cap and vibration or other movement is minimal, the powder can accumulate on the bottom surface of the passage, but it will be minimally dropped through the side passage.

  In some embodiments, the need to balance between air flow and minimal powder loss can be achieved by a mechanism that allows the air passage to be alternatively opened or closed. For example, in some embodiments, the capsule and cap components may mate, but may still be slidable relative to each other to allow the two configurations described below. In the closed configuration, the two components are closer together and the capsule base element closes the cap air passage. In the open configuration, the capsule and cap are slightly separated to allow air to flow through the air passage in the cap.

  In some embodiments, the mouthpiece, capsule, and / or cap is designed for single use (possibly disposable) or alternatively designed for multiple use. For example, in some embodiments, the capsules and caps are disposable and may optionally be utilized with a variety of powders, while the mouthpiece may be reusable. In certain embodiments, pre-filled standard size capsules such as gel capsules or blister packs can be used. Such an embodiment allows for easier filling, replacement, cleaning and disposal. Furthermore, such embodiments allow for the production of multi-dose capsules. Such pre-filled capsules can be broken, cut or broken by design elements in the housing (eg, sharp tips, blades, compressing the device, or twisting the device, etc.) prior to use. In this way, the product may be released into the chamber and be susceptible to the air flow generated during inhalation or actuation, or as another example, the product may remain approximately in the original container. However, here it may be in fluid communication with the air flow generated during inhalation and / or actuation, and thus may be susceptible to that air flow, and so forth. After actuation and use, the emptied capsule can be removed from the compartment and conveniently discarded. Alternatively, the capsule can be designed for multiple use. For example, the capsule may be refillable.

  In some embodiments, by designing the housing to incorporate at least 2, for example 3, 4, 5, 6, 7, 8, 9, or 10 capsules, for example , Allowing the user to successfully combine different flavors in different amounts as desired. In some embodiments, the frequency of removing and replacing used capsules can be reduced by designing the housing to allow filling of a set of multiple capsules to be activated at once. .

  In some embodiments, the device is designed for use by at least two people, such as three, four, five, six, seven, eight, nine, or ten users. Yes. For example, a device with multiple branches, each designed with an air flow directing element, can be designed to allow simultaneous use by multiple users.

  In certain embodiments, the device comprises a housing, a capsule and a cap. In an alternative embodiment, the device comprises a housing and a cap, both the housing and cap being designed for use with a capsule, such as a disposable or refillable capsule. In other embodiments, the device comprises a disposable or refillable capsule. In other embodiments, the apparatus includes a mouthpiece for use with various aerosolized products, sources of aerosolized products, and / or containers for aerosolized products.

  Functions such as mouthpieces, capsules, caps, lattices, mouthpiece discs (i.e. product containment, aerosol generation, aerosol delivery, air flow (and aerosol direction), etc.), in some embodiments, It should be noted that while maintaining the same overall functionality, it can be associated with one or more potentially different physical devices. For example, in some embodiments, a single device unit may incorporate all functional aspects. In some embodiments, the mouthpiece may contain an aerosol generating device, an aerosol delivery device, and an air flow (and aerosol) directing device, and the product container may be independent. In some embodiments, as previously described, the product may be contained within a capsule and cap, the aerosol generating device may be part of the capsule, and a mouse with an airflow directing element The piece may be used to deliver aerosol from the capsule / cap to the user.

  Referring to FIG. 3, the user fills the device 100 (step 200), takes the device 100 into the user's mouth (step 210), and inhales through the mouthpiece 112 (step 212). The delivery device 100 is operated by allowing air to enter the cap and capsule through the air passage. The air causes the food powder present in the capsule 116 to be aerosolized via an aerosol generating device such as a lattice, and subsequently enters the user's mouth via the mouthpiece 112.

  FIG. 4 shows a multi-face view of an exemplary embodiment of the mouthpiece 112.

  FIG. 5 shows a multi-sided view of an exemplary embodiment of end cap 114.

  FIG. 6 shows a multi-sided view of an exemplary embodiment of capsule 116.

  In some of the above-described embodiments, the aerosol is generated at a specific time or over a short time interval corresponding to a specific actuation process, and / or the aerosol is generated by a user-dependent process. For example, in some cases, aerosol generation is associated with one or more user inhalation actions. In many of these embodiments, the product is in a solid state and may be a substantially dry powder. However, our approach is based on a more continuous source of aerosol and / or a source located external to the user, such as one or more piezoelectric ultrasonic vibration disks, air pumps or compressed air sources. It also relates to other series of generated embodiments. Some of these sources may be more suitable for generating aerosols from substantially solid products, while others may be more suitable for generating aerosols from substantially liquid products.

  In some embodiments, the product is in a substantially liquid state, and aerosol generation by an ultrasound source in contact with the product involves liquid atomization in addition to subsequent aerosol cloud formation. . For example, in some embodiments, a piezoelectric vibrating disk is placed in a liquid product, and the ultrasonic vibration of the disk generates an aerosol at the liquid surface.

  In many of the embodiments described above, the aerosol is generated within the housing, mouthpiece, capsule and / or cap and delivered directly to the user via the housing and / or mouthpiece. In embodiments where an aerosol that is not substantially confined (e.g., an aerosol cloud such as an aerosol cloud generated by an external source such as an ultrasound source) is used, in order to elicit significant taste in the subject It may be necessary to produce a highly concentrated aerosol. However, highly concentrated aerosols have a high rate of collisions between particles, and over time, the aerosol becomes increasingly dilute as it diffuses into the surrounding air, due to inertial collisions and diffusion, etc. Or the particles may coalesce (for example if it is a liquid aerosol). Other concentration ranges may be selected, for example, to balance taste, aesthetics, and other factors associated with intake of aerosolized products that are not substantially trapped. Thus, in some embodiments, the aerosol cloud may be trapped within a pot or other (transparent, opaque, or translucent) medium or container. In certain embodiments, closed bubbles are used to confine the aerosol, keeping the aesthetics of the “floating” aerosol (whether the aerosol is floating in the container or bubble and / or the container or bubble itself is floating) ), At the same time maintaining a higher aerosol concentration, enabling more efficient aerosol delivery to the mouth than by “eat” in open air or by inhalation of open air. The aerosol bubbles or the container itself can be edible in some cases. In some cases, the bubble or container may be opened to provide access to the aerosol.

  An external source, such as an ultrasound source, may be located within the containment medium or containment vessel. In media or containers that are not completely closed from the outside environment, for example pots, the height of the media or containers is opened with the need to protect against convection, diffusion, inertial impacts and other forces, for example. It is chosen to balance the need for access to the aerosol, such as through the top, through a small opening, through an opening that can be closed at a particular time.

  With reference to FIGS. 7A and 7B, the delivery device 300 includes a container 310 containing a product 312. A force generator 314 (eg, an air pump or compressed air supply) is attached to the container 310. When activated, the force generator induces aerosolization of the product 312 by passing the product 312 through the aerosolization component 316 and subsequently releasing it to the external environment. The resulting aerosol cloud 318 can then be ingested, for example, by changing the position of the cloud or subject, or by inhalation.

  Referring to FIG. 8, a prototype with a hand pump as a force generator was constructed. The prototype produced aerosolized dehydrated mint particles using a hand-operated aerosol generator.

  With reference to FIGS. 9A-9D, the delivery device 350 includes a container 352 with a base 354 configured to stably support the container on a support surface (eg, floor or table). The aerosol generating device 356 is disposed within the internal cavity 358 of the container 352. Aerosol generator 356 (shown in more detail in FIGS. 10A-10D) includes a transparent plastic case 360 having an open top that receives aerosol generator 362. The aerosol generator can be, for example, an ultrasonic generator or a piezoelectric generator.

  Referring to FIG. 11, the product can be placed in the case 360 of the aerosol generating device 356 of the delivery device 350. When the generator is activated, the product is aerosolized and optionally passes through the open top of the case 360 of the aerosol generator 356 into the internal cavity 358 of the container 352. In some examples, the aerosol mixture is thick enough that the aerosol mixture remains substantially within the container 352. The container 352 has a top opening that extends through the container to an internal cavity 358 that is perpendicular to the base when the delivery device 350 is positioned with the base 354 resting on a support surface. It is shifted in the direction. In some examples, the top opening of the container can be closed by a cover.

  The delivery device can be formed with other profiles. Referring to FIGS. 12A-12G, a dodecahedral container 410 of a similar delivery device 400 receives an aerosol generating device 412. Referring to FIG. 13, in use, the delivery device 400 can be placed with the open face straight up. Referring to FIG. 14, in use, the delivery device 400 can be positioned with the open surface angled upward relative to the support surface.

  The delivery mechanism can be used to carry the aerosol or a portion of the aerosol to the user. In some embodiments, the delivery device comprises a mouthpiece as described above. Since the aerosol may be generated independently of the delivery device, the delivery device may consist solely of a mouthpiece with an air flow directing element that directs the aerosol to the oral surface by inhalation as described above. In some embodiments, for example, it may be advantageous to lengthen the delivery device for easy access by aerosol without interfering with any aerosol containment structure or device. In some embodiments, the delivery device is an elongated mouthpiece. In some embodiments, the delivery device is a mouthpiece connected to a separate device that serves to essentially extend the length of the mouthpiece, eg, a hollow cylinder. (In some cases, this device may allow a user to use his own mouthpiece while using the same extension device as other users. This is expensive. It can be considered a hygienic way for multiple people to taste the aerosol without having to make a large number of long mouthpieces to obtain). In some embodiments, the delivery device is a “food straw”.

  In some embodiments, the delivery device can be used directly, while in other embodiments, additional intermediate steps are required to confine a smaller amount of aerosol cloud after aerosol generation and before (or during) delivery. Can be implemented. This configuration helps closer to the concentrated portion of the aerosol cloud within the delivery device, improving or creating possible detectable and / or detectable taste. This is also partly due to hygiene concerns (whether realistic or illusion) for the joint use of a single aerosol generating device by separating the clouds into individual “portions” before ingestion. I can respond.

  For example, according to an aerosol generating device (eg, an ultrasonic device in a liquid product) located in a pot or other container, the aerosol cloud is collected in a smaller container such as a glass, champagne flute, soup ladle, etc. And then a delivery device (eg, a mouthpiece) can be used with the smaller container. For example, the mouthpiece can be placed in a glass or other container, and by inhalation, the cloud in the glass or container is delivered to the user's mouth. The air flow directing element in the mouthpiece will help direct the particles to the surface in the mouth and limit the extent to which the particles can continue to travel further into the respiratory tract.

  In certain embodiments of independent liquid aerosol generators (eg, using a piezoelectric source and / or an ultrasonic source), typically a significant number of larger droplets that reach well beyond the cloud range. Exists. Thus, attempts to ingest product from the cloud typically involve, for example, blocking these droplets and / or staying at a distance from the cloud and / or consumer droplets. Encourage the use of a mechanism that prevents these droplets from hitting the consumer by using a delivery device that minimizes exposure to water.

  Attempts to use a grid with a pore size smaller than the problematic larger droplets and larger than the cloud droplets on the ultrasound source proved unsuccessful in the test. Although the cloud particles could somehow pass through the pores, as a whole, they did not have enough kinetic energy to easily pass through the lattice and produce a large and dense cloud.

  One effective solution is to provide a cover or cover on the cloud to limit large droplets from popping out. In some embodiments, this cover concept can be realized by placing a larger cover over the entire container (see, eg, FIG. 11) that is removed just before use. In some embodiments, the remote surface or side of the container may extend slightly above the location of the ultrasound source, thereby preventing some ejected droplets. In some embodiments, access to the cloud may be through a side opening or space (see, eg, FIG. 14). In some embodiments, the ultrasound source can be positioned at an angle so that the source faces the side of the container, or any non-open portion of the overall device, thus allowing the droplets to Rather than outside or outside of the open side, it mainly discharges to the corresponding opposite side (see eg FIG. 13).

  For these embodiments, the container may or may not be attached to a system having various sizes and orientations, and / or other parts of the device, or Many equivalents are possible, including systems where there are covers with various sizes, shapes and orientations that may or may not be connected. Overall, the presence of any form of solid surface that prevents the larger droplets from popping out at a distance from the source to allow clouds to be easily formed is It should be regarded as another example with respect to the described embodiments.

An alternative is the use of a delivery device that allows ingestion at a distance. For example, a mouthpiece having an airflow directing element can be used. In some embodiments, the mouthpiece is elongate and can function as a “straw” for delivery over longer distances. In some embodiments, the elongate mouthpiece consists of two parts: a mouthpiece and an extension piece. For example, the mouthpiece has an airflow directing element and may incorporate a cylinder of a particular diameter and length. The extension piece may be of a fixed length with a similar diameter connected (eg, fitted, snapped, threaded, etc.) to the mouthpiece, for example. In this latter system, the mouthpiece and extension can be replaced independently (eg, each user may have one mouthpiece and each person may use the same extension).
Aerosol activation and product delivery

  An aerosol generating device is any device capable of generating an aerosol of desired characteristics (ie, particle size, dwell time / floating duration, release amount, etc.). In addition to aerosol generators, additional airflow control devices, containment spaces containing aerosols, vents in inhalers, mouthpieces, airflow directing elements, or aerosol delivery to the subject's mouth There may be delivery devices such as other devices or structures that make, facilitate or optimize. For example, FIGS. 2A-6 show capsules and caps that, in many embodiments, function as product containers and incorporate an aerosol generating device (consisting primarily of a grid). In many embodiments, the capsule and cap are connected to each other and connected to a mouthpiece with an airflow directing element. Here, the mouthpiece functions as a delivery device.

  By controlling gravity and inertial forces, the airflow directing element found in some embodiments allows the aerosol cloud to be delivered to a substantially oral surface rather than the underlying respiratory organ. To do. This aspect of the technology is very suitable for many possible uses of aerosols. In fact, such a delivery device minimizes or eliminates cough and potential interaction with the respiratory system surface beyond the mouth, and a wide range of aerosols produced in many different ways. Enabling delivery to consumers.

  The design of any of the devices or structures associated with this technology also considers reducing the tendency of coughing, nausea, or otherwise unfavorable response to aerosols. Or may attempt to reduce such trends.

  These devices and related devices (such as food storage devices) can be embodied in a vast number of different ways. The apparatus described in this application is exemplary.

Induction of product aerosolization and subsequent delivery of the resulting aerosolized product includes, but is not limited to, breathing, device actuation, body displacement, aerosol displacement, and combinations thereof. It can be brought about by various means. For example, such operations include the following.
a) exposure of the product to the aerosol generating device and delivery of the aerosolized product to the mouth, e.g. inhalation by inhalation in the mouthpiece; and / or b) activation of the ultrasound source, pump Actuation, actuation of a compressed air source, actuation of an impeller, puncture of a container, opening of an air passage, and operation of device actuation, including but not limited to aerosolizing the product or Helps to aerosolize (the aerosol formed thereby is in a substantially confined space (eg a spacer) or in a substantially open space (eg as a “cloud” in the air or in a confined structure) And / or c) an aerosol (eg, contained in a spacer device or with a cloud) Use of straws, mouthpieces or other devices that are directed "on top" or "towards"), which are freely levitated or contained within a larger structure Facilitated by movements of breathing; and / or d) movements of the body such as walking or tilting the body (sometimes in the mouth, tongue or in a particular way) In conjunction with other arrangements or positioning of other body parts) by exposing the subject's mouth to an aerosol cloud or a portion of the aerosol cloud, resulting in a substantial accumulation of particles in the mouth Motion and / or motion of aerosol displacement caused by e.g. air flow, thermal or pressure gradient, inertial collision, diffusion or gravity, By bringing the aerosol cloud or part of it in place so that the subject's mouth is exposed to the aerosol cloud, the deposition of particles in the mouth substantially results in dilution of the particle concentration and diffusion of the cloud. Motions of aerosol displacement; and / or f) additional motions such as device activation, device use, spatial restraint, airflow confinement, or mouth, lips, tongue, jaw, head or Additional movement of positioning or positioning, such as other body parts in certain forms, shapes, etc .; or other additional movements that help provide proper aerosolization and / or delivery and / or taste of the product ( For example, using food straws, opening / closing the containment chamber, lifting the tongue to divert air flow, etc.). Such an action can be used to help reduce the tendency to cough, nauseate, or otherwise show an unfavorable response to the product.

  All references to powders, liquids, aerosols, clouds, particles, etc. made in this application may equally refer to a certain fraction or part of the total amount of powders, liquids, aerosols, clouds, etc.

  For example, the device itself can be designed for single use (eg, disposable) or multiple uses. In that case, the dosing capsule is replaced or the dosing chamber is refilled. Alternatively or additionally, parts of the device, such as mouthpieces, food storage devices, capsules, and / or caps, may be disposable. In some embodiments, the device may incorporate a force generating mechanism, such as a pump or a source of compressed air, to aerosolize the product. In some embodiments, the device may incorporate a propellant.

  In some embodiments, the device is intended to aerosolize and / or deliver the product in a single short-term process (eg, a single inhalation on an inhalation inducing device), or multiple separate Intended to be aerosolized and / or delivered in multiple steps (eg, multiple inhalations on an inhalation inducing device), or longer-term continuous steps (eg, maintaining an aerosol cloud in open air) Depending on whether it is intended to be aerosolized and / or delivered through, the device may be designed for aerosolization and / or delivery by “single motion”, “repetitive motion”, or “continuous motion” . Here, “step” refers to any combination of simultaneous and / or sequential processes by which the device aerosolizes and / or delivers the product. Many factors can determine which of these steps (if any), including whether the device is intended for use by one subject at the same time or for use by multiple subjects at the same time. It will help determine if it is appropriate for any particular embodiment.

  The device may also include additional items such as spacers, lights, valves, etc. to enhance visual effects and / or control over aerosol and / or dosage. These adducts can also improve the experience of inhaling aerosols.

  In some embodiments, the entire device body or a portion of the device can be made from edible / ingestible materials such as cookies, crackers, chocolates or sugar products. This will allow the device to be enjoyed either during or after aerosol delivery, thereby improving the overall experience.

  In some embodiments, the device is an inhaler or inhaler device, such as a dry powder inhaler (DPI)) or a metered dose inhaler (MDI); holds an ultrasonic source and is produced by that source A “pot” that traps some aerosol clouds; a “spouter” that ejects and / or circulates aerosols; a hand-held pump device; a compressed air device; a food straw device; a multi-person co-device; Various materials can be used to form the device or part thereof, including plastics (eg, relatively strong polycarbonate, polypropylene, acrylonitrile butadiene styrene, polyethylene, etc.), various metals, glass, cardboard, hard paper, and the like. .

  In some embodiments, the aerosolized product is of limited size, i.e. sufficient to limit entry into the respiratory tract, but sufficient to allow air suspension. Should be small in size. In some embodiments, the particle size is related to a pre-atomized near solid product, such as a product placed inside a capsule / cap of a particular embodiment, or an air pump or compressed air source. There may be manufacturing requirements for the particular dry product used. In some embodiments, the particle size is an aerosol for a (typically liquid) product that is simply atomized by the generation of an aerosol, for example, for a product used in conjunction with an ultrasound source to generate an aerosol cloud. It can be a requirement of the generator.

  In some embodiments, the predetermined average dimension of the aerosolized product is at least 1, 2, 3, 4, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 70, 75, 80, 95, 100, 105, 110, 115, 120, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 185, 190, 195, 200, 205, 210, 215, 220, 225, 230, 235, 240, 245, 250, 255, 260, 265, 270, 275, 280, 285, 290, 295, 300, 325, 350, 375, 400, 425, 450, 475 or 500 microns. In some embodiments, the predetermined average dimension of the aerosolized product is 500, 450, 400, 350, 325, 300, 275, 250, 245, 240, 235, 230, 225, 220, 215, 210. , 205, 200, 195, 190, 185, 180, 175, 150, 140, 130, 120, 110, 100, 90, 80, 70, 60, 50, 40, 30, 20 or less than 10 microns is there. Intermediate ranges between the above listed ranges, such as about 50 microns to about 215 microns, are also intended to be part of this disclosure. For example, it is intended to include a range of values using any combination of the above values such as an upper limit and / or a lower limit.

  In particular, but not exclusively, in some embodiments where ingestion is by inhalation, the minimum particle size is an important feature of the approach. Aerosol particles are delivered and deposited substantially in the mouth, for example by the force of gravity or inertial impact, but are not designed to be easily delivered and deposited substantially further in the respiratory tract, for example in the trachea or lungs Has been. Accordingly, such particles will have a size that is larger (ie, greater than about 10 microns) than those focused on lung entry. For example, devices such as inhalers that are activated by breathing, such as the devices shown in FIGS. 5-17 (in part or in whole), if the aerosol particles are not of larger size (and of the delivery device) Without airflow directing elements, it produces an aerosol that will accompany the inhaled air towards the lungs fairly easily.

  In particular, but not exclusively, in embodiments where ingestion is due to a change in the position of the subject or a change in the position of the aerosol (eg having an aerosol cloud), the maximum particle size is an important feature of the approach. In practice, the aerosol cloud must remain floating in the air for at least a short time so that displacement into the mouth can occur. Thus, the particles should not be so large as to settle quickly from the air. This is due to the forces and / or mechanisms by which the particles are held in the air (eg only by “natural” forces such as inertia, diffusion, etc., or additional such as impeller, air flow, convection, etc. Very much). Thus, in some embodiments, the particles should be less than about 500 microns under typical buoyancy and mechanisms. For example, an ultrasonic source in a liquid product produces a stationary aerosol cloud that can balance gravity, diffusion, inertial collisions and other forces and remain floating in air as long as convection is minimal can do.

  The specific parameters of the device and method of intake will determine in part whether the subject is “inhaling” or “eating” when an aerosol ingestion occurs. This generally means that (1) the aerosol is entered into the subject's mouth and / or throat by inhaled air (while the epiglottis directs air into the trachea with air directed at the lungs), or Whether the aerosol enters the subject's mouth by another method (such as aerosol or changing the subject's position), and (2) the subject (physiologically preventing the epiglottis from passing through the trachea) The person's expectation corresponds to whether the aerosol is (eventually) a kind of food to be swallowed. In any case, it should be further noted that the product, after being deposited in the mouth, is eventually swallowed and essentially ingested like other typical products.

  In some examples, the aerosol is carried by inhaled air that flows all the way to the lungs (eg, inhalation that a smoker may have that carries air and tobacco smoke / smoke from the cigarette). May be released. In some examples, the aerosol may be carried by air that “stops” or “inhaled” in the mouth (rather close to the technique used with typical straws and beverages, or cigars). (In some examples, elements of both approaches may be appropriate.) This potential difference may have important implications for aerosol devices. For example, if the particles are carried by air that continues directly into the lungs, preventing the particles from depositing too far in the respiratory tract depends on physical parameters such as particles, airflow, and the like. If the particles are carried by the air sucked into the mouth, they may normally allow the particles to spread further into the respiratory system than desired, but the airflow “stops” in front of the lungs. Thanks to it, it may be possible to carry particles with an average size or other characteristics that cause the particles to fall substantially into the mouth.

  In some embodiments of the device where the aerosol is generated by inhalation, such as the devices shown in FIGS. 5, 6 and 20, an appropriately sized relatively dry solid powder may be used as the product. Preliminary studies have shown that the water solubility of the dry powder used is responsible for the taste and potential cough reflexes resulting from the ingestion of aerosolized products. Powders of particles that have a tendency to dissolve more rapidly in water, such as ground chocolate bars or certain chocolate-based powders, generally produce a pleasing reaction when the particles come into contact with the tongue and other surfaces in the mouth. In the case of a crushed chocolate bar, for example, the effect is similar in some cases to the effect of sensing chocolate melt very quickly in the person's mouth. Less water soluble particles, such as certain milled cocoa based powder products, feel more rough and tend to induce less comfortable reactions such as dry mouth or cough. However, in some cases, combining both types of powders in various proportions provides interesting flavor complexity.

  In some embodiments in which a liquid aerosol is generated, such as in the devices shown in FIGS. 9A-14, the aerosol generation and delivery device has an amount and / or concentration of aerosol sufficient to induce a significant taste. Is bound by the need to have Thus, in some embodiments, the density of the aerosol cloud, and the amount of aerosol consumed in a single inhalation or other single delivery step, is determined by the user's taste sensitivity, its product, and many other Depending on the condition, it must be higher than the minimum threshold.

For example, in some embodiments where a liquid aerosol is generated by an ultrasonic source in a liquid product, particles suspended in the liquid (eg, when the liquid is colloidal), the source may be an aerosol. In order to produce efficiently, it must generally be smaller than the size of the aerosol particles produced. Furthermore, in some embodiments with a liquid aerosol, for example in some embodiments with an ultrasonic source in a liquid product, the surfactant plays an important role in producing the desired taste. Not possible (according to preliminary tests, this is the case for wine). This is because aerosolization separates the surfactant from the rest of the product, increasing the proportion of surfactant in the liquid and thus distorting the true flavor of the product (eg in the case of wine) This is because the ratio of more acidic substances) is increased.
Products containing aerosol powder

  Can be aerosolized (particles much larger than 500 microns fall rapidly from the air unless supported by external forces) and there are few or no particles that enter the lungs during inspiration By designing food forms with sufficiently large particles (greater than about 1, 2, 3, 4, 5, 10, 15 or 20 microns), our technology results in deposition and delivery in the mouth . Ideally, the particles are, for example, at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least about 95%, at least about 97%, or at least About 99% will be designed (made to such a size) to deposit in the mouth and not spread further into the respiratory tract. The particle design should also take into account reducing any tendency to cough, vomit, or otherwise exhibit an unfavorable response to the aerosol.

  Dry powder particles can be formed by a number of different methods. Initially, the product can be dehydrated. Alternatively or in addition, if the food is a softer or liquid-based food, the food may be first frozen to facilitate subsequent grinding or shredding. The product can be subsequently crushed to form appropriately sized particles. The product can be crushed by the use of a mortar and pestle. Alternatively or in addition, the product may be shredded using, for example, a mechanical or electrical grinder, knife, or the like. The resulting crushed or shredded particles are subsequently filtered through a sieve (eg manually, using an electric or mechanical sieve shaker, by an air classification system, by a screening system, etc. ), An appropriate particle size can be obtained. Another approach is to use a powder mill that cuts large particles to a predetermined size. Spray drying can also be used in which the mixture of water and material to be dried is extruded through a nozzle onto a hot drum and the water droplets that cling to the material are immediately evaporated. In addition to others, these methods can be aerosolized, but the particles are sized to a specific size that is large enough not to easily pass through the mouth and throat and continue into the respiratory tract Will be possible.

  These dry powder particles are formed from a single food or ingredient such as chocolate, coffee or truffle, or a combination of food or ingredients such as a combination representing a whole dish or whole meal (eg mixed fruit or meat and potato) can do. In the case of chocolate, chocolate bars, chocolate powder, cocoa powder, and other forms and types of food derived from cocoa plants may be used. Further, in some cases, spices and other (natural or artificial) flavorings may be used alone or other tastes or sensations (eg natural or artificial chocolate, raspberry, mango, mint) , Vanilla, cinnamon, caramel, and / or coffee flavor) may be used in combination with such food ingredients. In addition, the device may contain a single dose of the product, or it may contain multiple doses / multiple doses of the product. Furthermore, they may be produced largely from liquid products, for example by extracting dissolved solids or by using other solid components. In some embodiments, the flavor can be experienced with a smaller amount of actual product compared to normal consumption. Furthermore, a new flavor can be created by mixing different powders.

  Aerosols are also liquids that are aerosolized, for example, by an ultrasonic source in communication with a liquid product, or by a “spray” mechanism similar to the mechanism for liquids and gases in a spray can (“aerosol can”) or nebulizer. It may be. Such liquids are concentrates, additives, extracts, or other forms of products that can be delivered in some way that preserves or enhances flavor, such as Can be prepared by a variety of processes to contain.

  The liquid aerosol may also be generated by an ultrasonic device, such as a vibrating piezoelectric disk, placed in a container of liquid product.

  Depending on the product and equipment used, the product can be in the form of tablets or pills, in blister packs, in capsules, simply as a jar-like container as a powder, and / or in a dish, box, container, thermos, It can be stored and / or contained in a bottle or the like.

  In some embodiments, properly designed and appropriately sized particles can be used to deliver a scent. The particles may be used independently of the embodiments described herein or enhance the aesthetic experience in addition to the embodiments described herein, ie, in addition to delivering aerosolized products May be used for

“Product”, “Aerosol”, “Particle” and other similar terms are used throughout this document and they typically refer to small solid particles derived from food, but these terms Optionally, it may refer to any of the other food-derived products described in this application.
Other potential properties of the aerosol

  Using humidity or other environmental atmospheric conditions that can vary with respect to time and / or space, time-sensitive or position-dependent changes in sensory detection and sensory conversion initiated in the aerosol and / or subject Can be triggered. These conditional triggers cause the particles to have various taste, olfactory, aerodynamic, chemical, physical, geometric, and / or other properties. The characteristics can then change taste, texture, color, size, aerosolization, and / or other aspects of the particles.

The purpose of such conditional incentives is generally to create a more interesting and dynamic experience for the subject. The incentive may depend on reaching a threshold atmospheric condition (eg, humidity greater than 50%) or a threshold associated with the subject. The atmospheric conditions may change the aerosol particles themselves and / or allow them to interact differently from the subject's sensory mechanisms. For example, in low humidity air, the aerosol may exhibit one chemical / physical state that imparts a first taste, and in high humidity air, a different chemical / physical that imparts a second taste. A state may be exhibited. As another example, an aerosolized aerosol may not initially have a taste and / or scent, or may have an initial taste and / or scent that is reminiscent of a particular product (eg, mouthfeel). Can be first detected by the subject via the olfactory system before ingesting the aerosol), and after the aerosol has been ingested through the mouth, the surrounding environment of the mouth can cause the aerosol to taste and / or A scenting aerosol change or a new taste and / or scent reminiscent of a different product may be induced. Over time, but while the product is still in the mouth, it may continue to release and evoke a different sense of the subject. Mechanisms such as these can be used to create the impression of eating various course meals such as an appetizer followed by a main course followed by a dessert.
Flight time / floating time

Depending on the particular embodiment, the product can be in the form of an aerosol (floating) for various durations. For example, in the case of the basis of the inhaler device, the product is typically only remain buoyant for a time inhalation and ingestion occurs, the time is, for example, about _^1/2 seconds or less, about 1 second Within about 3 seconds, within about 5 seconds, within about 8 seconds, within about 10 seconds, within about 15 seconds, or in some cases longer periods. Alternatively, if the delivery device operates by aerosol cloud generation, the product can be at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, It may remain floating in the air for 25, 30 or 60 seconds, or at least about 2, 5, 10, 15, 20, 30, 45, 60, 90, 120 or 180 minutes. Mechanical stirring of the aerosol cloud, for example by convection, can act to increase the time that the aerosol cloud is floating.
Application

  Our device can change how food is experienced, allowing for an improved aesthetic experience of food. For example, the device can allow a subject to experience food by exposing itself to a room filled with, for example, a cloud of food, an immersive chamber, and a food straw. In fact, businesses, restaurants and nightclubs can provide such a “food experience”.

  In some embodiments, our technology allows subjects to experience food by exposing themselves to aerosolized food with personal handheld and / or portable devices. Can be. In some embodiments, our techniques may be used and / or associated with a social context similar to eating candy or smoking cigarettes. For example, some embodiments may be carried and used at various times throughout the day, or may be used simultaneously by multiple users.

  In various other embodiments, for example, a single aerosol generating device is associated with a number of delivery devices, such as pot-like containers that contain a liquid aerosol cloud, said aerosol cloud being activated by breathing, In embodiments delivered to multiple subjects each using a separate mouthpiece device with an airflow directing element, the technique provides a common experience while multiple subjects are aware of the aerosol. It may be possible to have.

  In addition, the device may function to provide nutrition to subjects who cannot chew or are not convenient in delivering food. For example, the delivery device may be useful for elderly or young children who are unable to chew or eat. In addition, certain embodiments of the invention as a way for a patient with a pathological condition that needs to be fed in a particular way (eg, by feeding tube or intravenously) to experience and taste food again. May be used.

  The device may also function to facilitate ingestion of drugs that may not be a pleasant taste. For example, when used with oral drug delivery, the device can provide an additional flavor that masks the flavor of the drug.

  Alternatively, the proposed delivery device may be used for weight management or addiction alleviation applications. For example, the delivery device may allow a subject to consume a relatively small or negligible amount of product or a particular health or addictive substance. Exposure to particles by the device usually results in a sense or satisfaction associated with ingestion of large quantities of the food or substance in question, thereby resulting in actual consumption of large quantities of the substance (possible Can potentially satisfy hunger or addictive urges without consequences. In some examples, this may be due to the higher surface area of the product exposed to the mouth surface, e.g. exposed to taste receptors, relative to the overall amount (e.g. mass) of the product. . In fact, delivery devices can be used in diet, weight management and healthy diet programs (eg by satisfying the desire for sweets, fatty foods, chocolate and caffeine) and addiction treatments (eg alcohol, smoking, drugs Can form the basis (with a very small amount of less harmful).

  Furthermore, the delivery device may be used to improve the quality of life, for example for patients subject to special dietary restrictions. For example, a delivery device may induce an allergy or a physical response in a patient suffering from an allergy (eg gluten allergy) or other symptoms (eg lactose intolerance) that usually cannot consume a particular product Without allowing a relatively small or very small amount of these products to be consumed, perhaps giving a sense or satisfaction usually associated with large consumption of the food or substance in question.

  In addition, the delivery device can serve as a means for tasting multiple items in a simple and efficient manner. For example, a restaurant sponsor can sample various dishes on the menu before making a selection. In addition, the chef may use the delivery device to test food combinations while cooking or creating recipes. Similarly, the device can serve as an aid in cooking lessons, as an international “meal” experience for the subject, and as a way to teach children about food.

  Other useful uses of the delivery device include, but are not limited to, starvation relief (eg, in food emergency situations) and animal feeding.

The following examples are considered illustrative and are not intended to limit the scope of the claims.
Example 1

A mint powder sample having an approximate initial average particle size of at least about 140 microns was used to assist in determining the ideal particle size for aerosolization from a single-acting dry powder inhaler. The dried mint powder was ground using a mortar and pestle. The average particle size was reduced to ˜11 microns as measured using a HELOS-RODOS particle size measurement system. Different sized particles were placed in separate size 3 capsules and tested in a hand-held inhaler.
result

  The test was performed with samples of mint particles having approximate average particle sizes of 140 microns, 111 microns, 72 microns, 40 microns, 18 microns and 11 microns. Capsules (each containing about 30-120 mg of mint) were placed in the aerosolizer and punctured, and the inhaler was activated to release particles into the air. Most of the particles were seen to fall within 5 seconds after discharge, but this percentage decreased as the sample size decreased. The ratio was relatively high in tests with approximate average particle sizes of 140, 111 and 72 microns and relatively low in tests with approximate average particle sizes of 40, 18 and 11 microns. Tests with estimated average particle sizes of 18 microns and 11 microns yielded a nearly mist-like uniform plume with fewer visually distinct particles.

  FIG. 15 shows the density distribution and cumulative distribution for four trials with the same sample. These data indicate that for this particular sample, approximately 87% of the particles are greater than about 10 microns and approximately 79% of the particles are greater than about 20 microns. These findings indicate that the dried product (mint leaf) can be substantially aerosolized particles of a size that typically deposits in the mouth by inhalation (eg, between at least 18-70 microns). ing.

  In a sample of particles whose average is approximately in this range, a small or very small portion of the particles can enter the throat and lungs, but a significant portion of the particles are at least 5 after a single inhaler actuation. Continue to float for seconds.

With larger or more continuous aerosolization forces, such as a fan that runs continuously or intermittently, a clearly larger particle size can be aerosolized over at least a similar length.
Example 2

  An aerosolized delivery device as shown in FIGS. 16-18 was designed to deliver aerosolized chocolate. Chocolate was chopped into fine particles and then screened according to size. Many readily available chocolates have been found to remain sufficiently dry to be aerosolized in the delivery device described, as long as care is taken not to touch the particles excessively when ground. Excessive contact with the particles will cause them to melt rapidly and coalesce. The dryness of commercially available chocolate or cocoa powders makes such powders useful for creating different aerosol taste experiences, making the powders much more stable (eg, less prone to dissolution) Is possible. With a sieve, a specific particle size range can be selected, and samples containing a large number of particles with diameters in the range of approximately 125-180 microns (probably among other particle size ranges) And was found to be suitable for aerosolization. Also, certain particles may be sized to fall from the air before reaching the deeper respiratory system (> 10 microns), even when sized to reach the order of about 100 microns or more. It may also cause a cough reflex, but it has also been found to be significantly reduced with the airflow oriented mouthpiece element. It has also been found that the water solubility of the particles may contribute to the possibility of inducing a cough reflex. Such water solubility is likely to affect the taste, texture, and other taste aspects of the experience. For example, in some cases, highly water soluble particulate flavors are preferred because the flavors are recognized more quickly and / or have greater impact. Particles substantially larger than 180 microns become increasingly difficult to aerosolize and simply start to taste like chocolate pieces dropped on the tongue.

To simplify the filling procedure, it was determined that standard size 3 and size 4 capsules contained an amount of chocolate powder appropriate for a single dose “dose”. Thus, a number of such doses can be prepared for transfer to the powder compartment of the delivery device using a standard manual capsule filling machine.
Example 3

  An aerosolized delivery device 500 as shown in FIGS. 19A and 19B was designed to deliver an aerosolized beverage. Details of the delivery device 500 are shown in FIGS. 19C-19L.

  As described above, an aerosol cloud of edible material can be formed by sonication of a liquid. These clouds are sufficiently large in size that if they are inhaled they can be inhaled for ingestion, avoiding the respiratory tract.

  However, the use of piezoelectrics that generate such clouds in liquids, for example, can have several disadvantages. First, the clouds produced tend to aggregate aerosol particles with a very broad particle size distribution. Very large particles tend to entrain smaller particles and the cloud properties may not be suitable for inhalation and ingestion of edible substances. In particular, these inhaled clouds tend to have a relatively small amount of aerosolized mass, and there is no dominant proportion of particle sizes that are most suitable for delivery to the mouth, such as 60-300 microns. This arrangement also produces clouds by raising the nature of the fountain.

  The inventors have discovered that ingestible aerosol clouds can be generated by sonication and other means that circumvent these problems and present many effects on the inhalation feeding experience. The delivery device 500 as shown in FIGS. 19A and 19B allows large particles to rise and fall over the source, but smaller particles can cause lateral movement of the cloud, particularly near the liquid surface 508. In some cases, the aerosol cloud is displaced laterally with respect to the source of the aerosol cloud so as to move laterally by diffusion and convention and leave the falling large droplet.

  An exemplary delivery device comprises an aerosol delivery device that releases an aerosolized product generally along a generally vertical axis 518 (see, eg, FIG. 19B). Large and medium droplets fall by gravity in a lateral direction by convection, and therefore can be formed to be a stable standing cloud if there is a side chamber that can accommodate the cloud. There are fine aerosol particles. This cloud can be designed to have particles in the range of delivery to the desired mouth by manipulating the properties of the liquid, including the size of the cloud container and the surface tension of the liquid. It should be noted that a surface tension lower than about 72 dynes / cm, which produces an excellent standing cloud aerosol, can be achieved by the use of a surfactant.

  In the exemplary delivery device 500, a container attached to the aerosol delivery device defines a primary chamber 520 and a secondary chamber 522. The primary chamber 520 has a vertical axis 518 along which the delivery device emits particles extending into the primary chamber 520 and at least a first sized particle tends to rise and fall along the substantially vertical axis 518. Is hydraulically connected to the aerosol delivery device. The secondary chamber 522 is adjacent to the primary chamber 520 and is open to the primary chamber 520. Secondary chamber 522 extends horizontally outward from primary chamber 520 such that particles smaller than the first size have a tendency to disperse from primary chamber 520 to secondary chamber 522.

  The aerosol delivery device has a fluid reservoir with an ultrasonic generator. A fluid free surface 508 in the fluid reservoir is exposed to the primary chamber 520 of the container. The lower surface of the secondary chamber 522 is angled such that the liquid landing on the lower surface of the secondary chamber 522 has a tendency to flow toward the fluid reservoir 524. The surface of the primary chamber includes a surface extending across the generally vertical axis 518 to limit the movement of particles moving along the generally vertical axis 518.

  The container defines an opening extending through the container to an internal cavity. For example, the opening 526 is offset in a vertical direction from the aerosol delivery device when the delivery device is positioned for operation. The container thus defines an opening 526 that opens from above into the secondary chamber 522.

  In addition, an opening or spout 510 can thereby be formed through which the cloud flows into a glass or other container, which is a convenient and useful way of eating material by inhalation. This opening may be a closable outlet 510 located on the side surface of the container. The closable side outlet 510 may comprise an opening and a cap biased to close the opening. In some examples, an elastic member is disposed to bias the cap to cover the opening. In some examples, the cap is biased so that the weight of the cap covers the opening.

The apparatus can be a tabletop unit or an independent unit with a base configured to stably support the container on a support surface. For example, the delivery device 500 can comprise / attach to a stand as shown in FIGS. 19A and 19B. The delivery device 500 can also be placed directly on a flat surface such as a table.
Example 3A

For example, an aerosolized food composition suitable for use with the delivery device shown in FIGS. 19A and 19B can take different forms. Since delivery devices typically operate by creating an aerosol from a liquid, the food composition used therein is in liquid form. Unless otherwise noted, the components listed below can simply be mixed to form a substantially uniform liquid.
Lemon tart 598-732 mL (e.g., 665 mL) of lemon juice (e.g. Andros brand press lemon juice marketed in France).
• 301-369 mL (eg, 335 mL) of water • 58-72 g (eg, 65 g) of sugar • 9-11 g (eg, 10 g) of liquid cookie flavoring (eg, QL38457 available from Givaudan, Vernier, Switzerland)
Strawberry tart 0.9-1.1 (eg 1 L) water 180-220 g (eg 200 g) strawberry syrup (eg commercially available from Teisseire, Chlor, France)
11-13 g (eg 12 g) liquid cookie flavors (eg DR04295 available from Givaudan, Vernier, Switzerland)
Tart Tatan ^*
360-440 mL (eg 400 mL) of apple juice (eg Tropicana® apple juice)
• 540-660 mL (eg, 600 mL) of water • 126-154 (eg, 140 g) of sugar • 10-12 g (eg, 11 g) of liquid cookie flavoring (eg, DR04295 available from Givaudan, Vernier, Switzerland)
^* The ingredients of tartotatan should be prepared as follows:
60 g of sugar is caramelized to “Blonde” (initial / golden).
Cooling / diluting it with water Example 4 adding remaining sugar and other ingredients

  Another aerosolized delivery device 600 as shown in FIGS. 20A and 20B was also designed to deliver aerosolized particles. Details of the delivery device 600 are shown in FIGS. 20C-20G.

  The delivery device 600 includes a mouthpiece 610, a cap 612, and a capsule 614 that can contain particles. The delivery device 600 includes a capsule 614 that allows the mouthpiece 610, cap 612 and capsule 614 to have different relative overall lengths, disc sizes, and the mouthpiece 610 initially seals the top of the capsule 614. It differs from other embodiment (for example, refer to Drawing 2A-Drawing 2G) by having contact between mouthpiece 610 and it. The mouthpiece 610 is shorter and the capsule 614 is longer. The diameter of the disc is increased to be equal to or nearly equal to the outer diameter of the mouthpiece. The capsule 614 is initially inside the mouthpiece 610 and extends most or all of the length of the mouthpiece 610.

  The mouthpiece 610 is generally cylindrical. A further cylindrical portion 618 (see FIGS. 20H and 20I) located below the mouthpiece disk 616 fits into the top of the capsule 614 and is aerosolized when the user breathes through the mouthpiece 610. A grid (not shown) from which is released is sealed. The diameter of the disc 616 is the same or almost the same as the outer diameter of the mouthpiece 610. In one exemplary embodiment, the outer diameter of the mouthpiece 610 was 0.64 inches.

  Capsule 614 is also generally cylindrical. The end of the capsule 614 that fits into the mouthpiece 610 includes an annular ring 620 that extends axially outward from the remainder of the capsule 614 (see FIGS. 20G-20I). When the capsule 614 is fully inserted into the mouthpiece 610, the annular ring 620 is sized to fit and engage around an additional cylindrical portion 618 under the mouthpiece disc 616. Yes. Thus, the holes in the grid (not shown) on top of the capsule 614 can be covered prior to operation of the device 600.

  Capsule 614 is located at the bottom of capsule 614 and cap 612 is in an “air flow open” position (see FIGS. 20A, 20D and 20H) or an “air flow closed” position (see FIGS. 20B, 20F and 20I). Snaps 622 and 623 (see FIGS. 20G to 20I) that can be positioned in any of the above. Capsule 614 also includes snaps 624, 625 located near the top of the capsule. The snaps 624 and 625 are located in the lower “air flow closed” position (see FIGS. 20G-20I) and the higher “air flow released” position (see FIGS. 20A, 20D and 20H) of the mouthpiece 610. It is similar to the other two in that it makes it possible to do so.

  The closed position snaps 622, 625 were designed to be weaker than the open position snaps 623, 624, which need to be permanent (difficult to remove) because they need to be removed to activate the device 600. In some embodiments, the closure strength of the pair of snaps may be the same, or the open position snap may be weaker than the closed position snap.

  Prior to filling, the mouthpiece 610 and capsule 614 are mated. A cylindrical mechanism 618 located below the mouthpiece disk 616 and an annular ring 620 located above the capsule 614 are aligned to seal the top of the capsule 614 and fill the capsule 614. Maintain particles. The combined capsule-mouthpiece unit is then filled. Capsule 614 is then closed at the opposite end by the addition of cap 612. Due to its closure, the particles are protected from the environment and the air flow is restricted (e.g. by the three parts in the "closed" position, the air flow to / from the capsule 614 is almost blocked on both sides. ). The device can be provided to the consumer in this form (see, eg, FIG. 20D).

  For operation, cap 610 is pulled down (allowing airflow from the bottom) and then held by a snap (see, eg, FIG. 20E). The mouthpiece 610 is similarly pulled upward and then held by a snap to introduce a space between the top of the capsule 614 and the mouthpiece disk 616 to allow airflow to pass through the top. (See, for example, FIG. 20F). This is the “open” position and the device 600 can now be used.

The entire device can be discarded or reused after use. In the exemplary device 600, the mouthpiece 610, capsule 614, and cap 612 are configured to be permanently attached after assembly.
Example 4A

  For example, aerosolized food compositions for use in the aerosolized delivery devices shown in FIGS. 20A and 20B and FIGS. 2A-2G, as well as other types of devices, may meet the requirements of the intended end consumer or Different ingredients can be included to achieve different results based on requirements. Various types of ingredients (e.g. flavors, vitamins, nutritional supplements, sweeteners, Seasonings, herbal extracts and other types of ingredients) are listed in the table below. In some examples, the components can simply be mixed to form a substantially uniform powder mixture.

Example 4B
For example, an aerosolized food composition for use in the aerosolized delivery device shown in FIGS. 20 and 20A may be in the form of an aerosolized energy product. The following are examples of combinations of ingredients, a brief discussion on their use, and various observations from the tests. In some examples, the components can simply be mixed to produce a relatively uniform composition.
Ingredient description

  Caffeine (eg, 100% natural caffeine) is used as a major component to create a caffeine / lime flavored blend. Taumatin, a low calorie sweetener and flavor regulator, is used as a bitter and sweetener. Talin® is a commercially available thaumatin available from Naturex, Avignon, France. Talin® is usually sold in 10% purity mixed with 90% maltodextrin (also available in 100% purity). Stevia, also used as a sweetener, is commercially available from PureVia (TM), South Bend, Indiana, USA. Sugar (eg, sucrose for confectionery) is also used as a sweetener. Lime flavor is added as a major flavor to aerosolized products. Ref. Commercially available from Givaudan, Vernier, Switzerland. 96832-71 lime flavor has been shown to be suitable and is diluted with maltodextrin in this preparation. Citric acid is combined with sodium bicarbonate to act as a blowing agent. For best results, the blowing agent contains slightly more citric acid than sodium bicarbonate (eg, 3 parts citric acid for 2.8 parts sodium bicarbonate). Various mixed blend samples are shown in the table below.

Observations In some instances, adding more caffeine (eg, greater than 100 mg) may not seem desirable with respect to taste. Although Talin® has been shown to function properly in some instances, it is usually difficult to eliminate bitterness. Although the use of Talin® has a clear effect on bitterness elimination, the difference between Talin® 50 mg and 100 mg or between 50 mg and 200 mg (caffeine is 100 mg each) is not always obvious Rather, it was heavily dependent on other ingredients. The test is suitable bitterness even when using a fairly small amount of Talin® (eg 5 mg, 10 mg or 20 mg) with a ratio of Talin® to stevia of 1: 1 or 2: 1. Showed that the erase was achieved. The inventors believe that in some instances, the bitterness can still be adequately eliminated with less Talin®. We have found that Talin® is excellent at removing bitterness and sweetening at an earlier ingestion stage (eg, the first few seconds), and stevia sweetener is probably the later ingestion stage ( For example, it is considered that it has an excellent function of adding sweetness after 4 seconds). This can be further evaluated in more tests.

  The addition of a blowing agent (especially citric acid) may in some instances enhance the lime flavor more strongly than adding an equal amount of lime flavor. Effervescent agents generally also seem to help eliminate bitterness or at least distract from bitterness.

We also have, in some cases, adding a flavoring to try to eliminate bitterness can have a neutralizing effect on the foaming agent and usually does not help improve taste and / or bitterness. I discovered that. This can also be further evaluated in more tests.
Example 4C

  In addition to the energy products listed in Example 4B, for example, the energy product formulation for use in the aerosolized delivery device shown in FIGS. 20 and 20A can include various vitamins. Compositions used as aerosolized energy products containing vitamins may be made according to the recipe shown in the table below. In some examples, the components can simply be mixed to produce a relatively uniform composition.

For all formulations, in addition to the intended use or benefit of the product (providing energy / high caffeine, providing vitamins, providing flavor, etc.), there are no regulatory restrictions on taste and use of specific products within specific authorities All can contribute to the quantity used.
Example 4D to Example 4I

Further possible formulations are described below.
Example 4D

In some examples, the ingredients shown in Table 4-4 can be combined as follows:
Blend A: Sweeteners (Thaumatine and Stevia) are mixed with vitamins to form a consistent and uniform mixture.
Blend B: Mix caffeine, citric acid and sodium bicarbonate.
Blend C: Take Blend A and add flavors gradually by adding equal volumes in aliquots to form a uniform mixture.
Final mixture: Blend B and Blend C (now containing Blend A) are mixed together by adding equal volumes in aliquots to form a uniform mixture.
Example 4E

In some examples, the ingredients shown in Tables 4-5 can be combined as follows:
Blend A: Sweeteners (Thaumatine and Stevia) are mixed with vitamins to form a consistent and uniform mixture.
Blend B: Take Blend A and add flavors gradually by adding equal volumes in aliquots to form a uniform mixture.
Blend C: Mix caffeine, citric acid and sodium bicarbonate.
Final mixture: Blend B (now containing Blend A) and Blend C are mixed together by adding equal volumes in aliquots to form a uniform mixture.
Example 4F

In some examples, the ingredients shown in Tables 4-6 can be combined as follows:
Blend A: Sweeteners (Thaumatine and Stevia) are mixed with vitamins to form a consistent and uniform mixture.
Blend B: Mix caffeine, citric acid and sodium bicarbonate.
Blend C: Take Blend A and add flavors gradually by adding equal volumes in aliquots to form a uniform mixture.
Final mixture: Blend B and Blend C (now containing Blend A) are mixed together by adding equal volumes in aliquots to form a uniform mixture.
Example 4G

In some examples, the ingredients shown in Tables 4-7 can be combined as follows:
Blend A: Sweeteners (Thaumatine and Stevia) are mixed with vitamins to form a consistent and uniform mixture.
Blend B: Take Blend A and add flavors gradually by adding equal volumes in aliquots to form a uniform mixture.
Blend C: Mix caffeine, citric acid and sodium bicarbonate.
Final mixture: Blend B (now containing Blend A) and Blend C are mixed together by adding equal volumes in aliquots to form a uniform mixture.
Note: This particular flavoring material was shown to be fluffy and slightly moist, as opposed to stubborn wetness. This fluffy state can be the nutritional state of the material resulting from the spray drying process in creating it. Such fluffy conditions can present challenges that are addressed with the material.
Example 4H

In some examples, the ingredients shown in Tables 4-8 can be combined as follows:
Blend A: Sweeteners (Thaumatine and Stevia) are mixed with vitamins to form a consistent and uniform mixture.
Blend B: Mix caffeine, citric acid and sodium bicarbonate.
Blend C: Take Blend A and add flavors gradually by adding equal volumes in aliquots to form a uniform mixture.
Final mixture: Blend B and Blend C (now containing Blend A) are mixed together by adding equal volumes in aliquots to form a uniform mixture.
Example 4I

In some examples, the ingredients shown in Tables 4-9 can be combined as follows:
Blend A: Sweeteners (Thaumatine and Stevia) are mixed with vitamins to form a consistent and uniform mixture.
Blend B: Mix caffeine, citric acid and sodium bicarbonate.
Blend C: Take Blend A and add flavors gradually by adding equal volumes in aliquots to form a uniform mixture.
Final mixture: Blend B and Blend C (now containing Blend A) are mixed together by adding equal volumes in aliquots to form a uniform mixture.

Claims (20)

A composition comprising caffeine, a vitamin, a sweetener and sodium bicarbonate,
The composition has an average particle size of greater than 10 microns and less than 500 microns.   The composition of claim 1 further comprising citric acid.   The composition according to claim 2, comprising more citric acid than sodium bicarbonate, in particular the weight ratio of citric acid to sodium bicarbonate is 45 to 38 to 1: 1.   The composition according to any one of claims 1 to 3, wherein the sweetener comprises thaumatin and stevia.   The composition of claim 4, wherein the weight ratio of thaumatin to stevia is 11 to 4 to 9 to 6.   6. A composition according to claim 4 or claim 5, wherein the weight ratio of caffeine to the combined thaumatin and stevia is 25 to 2 to 90 to 17.   The composition according to any one of claims 1 to 6, further comprising a flavoring agent, in particular a natural flavoring agent.   The composition according to any of claims 1 to 7, further comprising a mineral supplement, in particular the vitamin comprises at least one of niacin, pyridoxine and cyanocobalamin.   A composition according to any preceding claim, wherein the average particle size of the composition is 18-70 microns. An aerosol generator;
A delivery device comprising a consumable substance comprising caffeine; vitamins; and sweeteners, wherein the reservoir is connected to the aerosol generating device for transferring the consumable material to the aerosol generating device.   The consumable material further comprises sodium bicarbonate and citric acid, in particular the composition contains more citric acid than sodium bicarbonate, more specifically, the weight ratio of citric acid to sodium bicarbonate is 45 11. The delivery device according to claim 10, wherein the delivery device is 38 to 1: 1.   12. A delivery device according to claim 10 or claim 11, wherein the sweetener comprises thaumatin and stevia, in particular the weight ratio of thaumatin and stevia is 11 to 4 to 9 to 6.   13. The delivery device of claim 12, wherein the weight ratio of caffeine to the combined thaumatin and stevia is 25 to 2 to 90 to 17.   14. A delivery device according to any of claims 10 to 13, wherein the consumable substance further comprises a flavoring agent, in particular a natural flavoring agent.   15. The delivery device according to any of claims 10 to 14, wherein the consumable substance further comprises a mineral supplement, in particular the vitamin comprises at least one of niacin, pyridoxine and cyanocobalamin.   14. The delivery device according to any of claims 10 to 13, wherein the consumable material has an average particle size of 18 to 70 microns. caffeine;
A composition comprising a vitamin; and a sweetener,
The composition has an average particle size of 18 to 70 microns.   Further comprising citric acid and sodium bicarbonate, especially containing more citric acid than sodium bicarbonate, more specifically, the weight ratio of citric acid to sodium bicarbonate is 45 to 38 to 1: 1. The composition according to claim 17.   19. A composition according to claim 17 or 18, further comprising a flavoring agent, in particular a natural flavoring agent.   20. A composition according to any of claims 17 to 19, further comprising a mineral supplement, in particular the vitamin comprises at least one of niacin, pyridoxine and cyanocobalamin.

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