JP2014519319A - エピジェネティックドメインの安定性の全般的な損失を通して癌を検出する方法およびその組成物 - Google Patents

エピジェネティックドメインの安定性の全般的な損失を通して癌を検出する方法およびその組成物 Download PDF

Info

Publication number
JP2014519319A
JP2014519319A JP2014510472A JP2014510472A JP2014519319A JP 2014519319 A JP2014519319 A JP 2014519319A JP 2014510472 A JP2014510472 A JP 2014510472A JP 2014510472 A JP2014510472 A JP 2014510472A JP 2014519319 A JP2014519319 A JP 2014519319A
Authority
JP
Japan
Prior art keywords
cancer
nucleic acid
methylation
acid sequences
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2014510472A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014519319A5 (enExample
Inventor
アンドリュー ピー． フェインベルク
ラファエル アイ． イリザリー
Original Assignee
ザ・ジョンズ・ホプキンス・ユニバーシティー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ・ジョンズ・ホプキンス・ユニバーシティー filed Critical ザ・ジョンズ・ホプキンス・ユニバーシティー
Publication of JP2014519319A publication Critical patent/JP2014519319A/ja
Publication of JP2014519319A5 publication Critical patent/JP2014519319A5/ja
Priority to JP2019166951A priority Critical patent/JP6954964B2/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2014510472A 2011-05-12 2012-05-10 エピジェネティックドメインの安定性の全般的な損失を通して癌を検出する方法およびその組成物 Withdrawn JP2014519319A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2019166951A JP6954964B2 (ja) 2011-05-12 2019-09-13 エピジェネティックドメインの安定性の全般的な損失を通して癌を検出する方法およびその組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161518892P 2011-05-12 2011-05-12
US61/518,892 2011-05-12
PCT/US2012/037362 WO2012154979A2 (en) 2011-05-12 2012-05-10 Method of detecting cancer through generalized loss of stability of epigenetic domains, and compositions thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019166951A Division JP6954964B2 (ja) 2011-05-12 2019-09-13 エピジェネティックドメインの安定性の全般的な損失を通して癌を検出する方法およびその組成物

Publications (2)

Publication Number Publication Date
JP2014519319A true JP2014519319A (ja) 2014-08-14
JP2014519319A5 JP2014519319A5 (enExample) 2015-06-25

Family

ID=47140012

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014510472A Withdrawn JP2014519319A (ja) 2011-05-12 2012-05-10 エピジェネティックドメインの安定性の全般的な損失を通して癌を検出する方法およびその組成物
JP2019166951A Active JP6954964B2 (ja) 2011-05-12 2019-09-13 エピジェネティックドメインの安定性の全般的な損失を通して癌を検出する方法およびその組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019166951A Active JP6954964B2 (ja) 2011-05-12 2019-09-13 エピジェネティックドメインの安定性の全般的な損失を通して癌を検出する方法およびその組成物

Country Status (5)

Country Link
US (2) US10752953B2 (enExample)
EP (1) EP2707506B1 (enExample)
JP (2) JP2014519319A (enExample)
AU (1) AU2012253414B2 (enExample)
WO (1) WO2012154979A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019522285A (ja) * 2016-06-16 2019-08-08 ザ・ジョンズ・ホプキンス・ユニバーシティ エピジェネティクス解析の為の方法及びシステム
JP2019535017A (ja) * 2016-10-06 2019-12-05 ザ・ジョンズ・ホプキンス・ユニバーシティ ラージスケールエピゲノムのリプログラミングは、膵癌進行の進展中の同化グルコース代謝を遠位転移に結びつける
JP2023551502A (ja) * 2020-12-04 2023-12-08 エボニック オペレーションズ ゲーエムベーハー トリ種における腸炎症状態を分類する方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3004478A1 (en) * 2015-11-06 2017-05-11 University Of Southern California Development of prognostic markers dsg-3 from the saliva of oral cancer patients
GB201703406D0 (en) * 2017-03-02 2017-04-19 Ucl Business Plc Diagnostic and prognostic methods
CN108796079B (zh) * 2018-06-06 2021-07-27 天津医科大学肿瘤医院 一种逆转录转座基因l1-fggy及其作为肺鳞癌标志物的用途
US12100517B2 (en) * 2018-10-29 2024-09-24 Flatiron Health, Inc. Generalized biomarker model
GB201819452D0 (en) * 2018-11-29 2019-01-16 Ucl Business Plc Differential methylation
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
US12467096B2 (en) 2020-05-15 2025-11-11 Universal Diagnostics, S.A. Methods and systems for identifying methylation biomarkers
WO2022002424A1 (en) 2020-06-30 2022-01-06 Universal Diagnostics, S.L. Systems and methods for detection of multiple cancer types
JP7709178B2 (ja) * 2021-12-09 2025-07-16 国立大学法人北海道大学 リンパ腫に罹患したイヌの化学療法後の予後予測方法
JP2023174077A (ja) * 2022-05-27 2023-12-07 株式会社日立製作所 Ｄｎａのメチル化レベルの測定方法、疾患予測システム、及び検査システム

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582908B2 (en) * 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
JP2005512499A (ja) 2000-09-01 2005-05-12 エピゲノミクス アーゲー 進行中の疾病または特定の疾病の発病素質の診断
JP2004524030A (ja) * 2001-02-23 2004-08-12 ザ ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン 膵臓がんにおけるメチル化の異なる配列
EP1442129B1 (en) 2001-10-18 2008-09-10 Lovelace Respiratory Research Institute Cancer monitoring by aberrant promotor methylation of the transcription factor genes pax5 alpha pax5 beta, novel loop helix loop protein, novel gene 2, and beta3 genes
JP2005204651A (ja) * 2003-12-11 2005-08-04 Epigenomics Ag 乳房細胞増殖障害の患者の治療応答及び／又は生存期間の予測のための予後診断マーカー
WO2009021141A1 (en) 2007-08-07 2009-02-12 The Johns Hopkins University Comprehensive high throughput arrays for relative methylation
US8399193B2 (en) * 2007-08-30 2013-03-19 City Of Hope DNA methylation biomarkers for lung cancer
WO2009113771A1 (ko) * 2008-03-14 2009-09-17 (주)지노믹트리 폐암특이적 메틸화 마커 유전자를 이용한 폐암 검출방법
WO2010062914A1 (en) * 2008-11-26 2010-06-03 The Johns Hopkins University Methods for identifying cancer risk

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BIOINFORMATICS, vol. 19, no. 2, JPN7018000232, 2003, pages 185 - 193, ISSN: 0003729681 *
BIOSATISTICS, vol. 4, no. 2, JPN7018000234, 2003, pages 249 - 264, ISSN: 0003729682 *
NATURE GENETICS, (2009), VOL. 41, NO. 2, P. 178-186, JPN6016009847, ISSN: 0003280880 *
医学のあゆみ, (2008), VOL. 225, NO. 7, P. 559-564, JPN6016009850, ISSN: 0003280883 *
実験医学, (2006), VOL. 24, NO. 8, P. 171-178, JPN6016009849, ISSN: 0003280882 *
実験医学, (2007), VOL. 25, NO. 17, P. 88-95, JPN6016009851, ISSN: 0003280884 *
実験医学, (2011.02.01), VOL. 29, NO. 2, P. 50-55, JPN6016009848, ISSN: 0003280881 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019522285A (ja) * 2016-06-16 2019-08-08 ザ・ジョンズ・ホプキンス・ユニバーシティ エピジェネティクス解析の為の方法及びシステム
JP7066643B2 (ja) 2016-06-16 2022-05-13 ザ・ジョンズ・ホプキンス・ユニバーシティ エピジェネティクス解析の為の方法及びシステム
JP2019535017A (ja) * 2016-10-06 2019-12-05 ザ・ジョンズ・ホプキンス・ユニバーシティ ラージスケールエピゲノムのリプログラミングは、膵癌進行の進展中の同化グルコース代謝を遠位転移に結びつける
JP7239468B2 (ja) 2016-10-06 2023-03-14 ザ・ジョンズ・ホプキンス・ユニバーシティ ラージスケールエピゲノムのリプログラミングは、膵癌進行の進展中の同化グルコース代謝を遠位転移に結びつける
US11795510B2 (en) 2016-10-06 2023-10-24 The Johns Hopkins University Identification of epigenomic reprogramming in cancer and uses thereof
JP2023551502A (ja) * 2020-12-04 2023-12-08 エボニック オペレーションズ ゲーエムベーハー トリ種における腸炎症状態を分類する方法

Also Published As

Publication number Publication date
US12454725B2 (en) 2025-10-28
WO2012154979A3 (en) 2013-03-28
AU2012253414A1 (en) 2013-11-21
JP2020010700A (ja) 2020-01-23
WO2012154979A2 (en) 2012-11-15
EP2707506A4 (en) 2014-12-24
US10752953B2 (en) 2020-08-25
JP6954964B2 (ja) 2021-10-27
US20210071262A1 (en) 2021-03-11
AU2012253414B2 (en) 2016-03-17
US20140128283A1 (en) 2014-05-08
EP2707506B1 (en) 2018-07-11
EP2707506A2 (en) 2014-03-19

Similar Documents

Publication Publication Date Title
JP6954964B2 (ja) エピジェネティックドメインの安定性の全般的な損失を通して癌を検出する方法およびその組成物
JP7594817B2 (ja) 血漿による胎児または腫瘍のメチロームの非侵襲的決定
JP7168247B2 (ja) 癌スクリーニング及び胎児分析のための変異検出
CN106795562B (zh) Dna混合物中的组织甲基化模式分析
CN108779487A (zh) 用于检测甲基化状态的核酸和方法
CN105518151A (zh) 循环核酸肿瘤标志物的鉴别和用途
CN110168108A (zh) 血浆中稀少dna的去卷积和检测
US20220025466A1 (en) Differential methylation
WO2022262831A1 (zh) 用于评估肿瘤的物质及其方法
EP3887549A1 (en) Molecular signature
EP4234720A1 (en) Epigenetic biomarkers for the diagnosis of thyroid cancer
HK40075963B (en) Non-invasive determination of methylome of tumor from plasma
CN115772566A (zh) 用于辅助检测肺癌体细胞erbb2基因突变的甲基化生物标记物及其应用
CN120330326A (zh) 一种癌症早筛相关甲基化标志物靶向捕获检测方法及其应用
HK40013800B (en) Non-invasive determination of methylome of tumor from plasma
HK1233684A1 (en) Methylation pattern analysis of tissues in dna mixture
HK1233684B (en) Methylation pattern analysis of tissues in dna mixture
HK1207124B (zh) 从血浆无创测定胎儿或肿瘤的甲基化组

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140221

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150508

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150508

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20150513

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160323

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160621

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160923

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170213

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170512

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170814

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180131

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180530

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20180607

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20180817

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190611

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20190917