JP2014515388A5 - - Google Patents

Info

Publication number

JP2014515388A5

JP2014515388A5 JP2014513184A JP2014513184A JP2014515388A5 JP 2014515388 A5 JP2014515388 A5 JP 2014515388A5 JP 2014513184 A JP2014513184 A JP 2014513184A JP 2014513184 A JP2014513184 A JP 2014513184A JP 2014515388 A5 JP2014515388 A5 JP 2014515388A5

Authority

JP

Japan

Prior art keywords

sucrose octasulfate

salt

compound according

solution

magnesium

Prior art date

2012-05-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 11
• 239000011777 magnesium Substances 0.000 claims 11
• WEPNHBQBLCNOBB-FZJVNAOYSA-N sucrose octasulfate Chemical compound OS(=O)(=O)O[C@@H]1[C@H](OS(O)(=O)=O)[C@H](COS(=O)(=O)O)O[C@]1(COS(O)(=O)=O)O[C@@H]1[C@H](OS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@@H](COS(O)(=O)=O)O1 WEPNHBQBLCNOBB-FZJVNAOYSA-N 0.000 claims 8
• 238000000034 method Methods 0.000 claims 6
• 239000000243 solution Substances 0.000 claims 5
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 4
• 206010052428 Wound Diseases 0.000 claims 4
• 208000027418 Wounds and injury Diseases 0.000 claims 4
• 229910052749 magnesium Inorganic materials 0.000 claims 4
• 238000004519 manufacturing process Methods 0.000 claims 4
• 230000002378 acidificating effect Effects 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 231100000241 scar Toxicity 0.000 claims 3
• 208000032544 Cicatrix Diseases 0.000 claims 2
• 201000004624 Dermatitis Diseases 0.000 claims 2
• 230000001154 acute effect Effects 0.000 claims 2
• 230000001684 chronic effect Effects 0.000 claims 2
• 239000002537 cosmetic Substances 0.000 claims 2
• 238000011033 desalting Methods 0.000 claims 2
• 159000000003 magnesium salts Chemical class 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• 239000012266 salt solution Substances 0.000 claims 2
• 230000037390 scarring Effects 0.000 claims 2
• 230000037387 scars Effects 0.000 claims 2
• 208000002874 Acne Vulgaris Diseases 0.000 claims 1
• 206010012444 Dermatitis diaper Diseases 0.000 claims 1
• 208000003105 Diaper Rash Diseases 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 208000007117 Oral Ulcer Diseases 0.000 claims 1
• 208000004210 Pressure Ulcer Diseases 0.000 claims 1
• 208000007107 Stomach Ulcer Diseases 0.000 claims 1
• 206010042496 Sunburn Diseases 0.000 claims 1
• 238000005299 abrasion Methods 0.000 claims 1
• 206010000496 acne Diseases 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 208000010668 atopic eczema Diseases 0.000 claims 1
• 208000007287 cheilitis Diseases 0.000 claims 1
• 238000000315 cryotherapy Methods 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 229910017053 inorganic salt Inorganic materials 0.000 claims 1
• 238000005342 ion exchange Methods 0.000 claims 1
• 210000003141 lower extremity Anatomy 0.000 claims 1
• 230000000813 microbial effect Effects 0.000 claims 1
• XISWAUUBQBEDFB-QRDGSJRXSA-F octapotassium;[(2r,3r,4s,5r,6r)-2-[(2s,3s,4r,5r)-3,4-disulfonatooxy-2,5-bis(sulfonatooxymethyl)oxolan-2-yl]oxy-3,5-disulfonatooxy-6-(sulfonatooxymethyl)oxan-4-yl] sulfate Chemical group [K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[O-]S(=O)(=O)O[C@H]1[C@H](OS([O-])(=O)=O)[C@@H](COS(=O)(=O)[O-])O[C@@]1(COS([O-])(=O)=O)O[C@@H]1[C@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H](COS([O-])(=O)=O)O1 XISWAUUBQBEDFB-QRDGSJRXSA-F 0.000 claims 1
• CPRSOZZDECJZKH-QRDGSJRXSA-F octasodium;[(2r,3r,4s,5r,6r)-2-[(2s,3s,4r,5r)-3,4-disulfonatooxy-2,5-bis(sulfonatooxymethyl)oxolan-2-yl]oxy-3,5-disulfonatooxy-6-(sulfonatooxymethyl)oxan-4-yl] sulfate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)O[C@H]1[C@H](OS([O-])(=O)=O)[C@@H](COS(=O)(=O)[O-])O[C@@]1(COS([O-])(=O)=O)O[C@@H]1[C@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H](COS([O-])(=O)=O)O1 CPRSOZZDECJZKH-QRDGSJRXSA-F 0.000 claims 1
• 230000001376 precipitating effect Effects 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• 208000006934 radiodermatitis Diseases 0.000 claims 1
• -1 sucrose octasulfate ester Chemical class 0.000 claims 1