JP2014196280A - Percutaneous absorption type tape for reducing uraroma - Google Patents

Abstract

PROBLEM TO BE SOLVED: To reduce uraroma to contribute to care environmental improvements, and to provide percutaneous absorption type tapes for reducing uraroma with easy use even if a cared person is a dysphagia person.SOLUTION: There are provided percutaneous absorption type tapes for reducing uraroma containing roasted rice bran extract as an uraroma-reducing substance.

Description

  The present invention relates to a percutaneous absorption type tape for improving urine odor to help improve the care environment. More specifically, the present invention relates to a transdermally absorbable tape preparation that transdermally absorbs roasted rice bran extract as a urine odor improving substance to improve the urine odor itself.

  One of the issues that needs to be improved in nursing care is the problem of “odor”. The odor at the care site includes the urine odor, fecal odor, halitosis, age-related odor and body odor of the cared person, as well as disease-specific odors such as infectious pressure ulcer wound odor and cancer due to the progression of symptoms. Is serious. According to Non-Patent Document 1, when the patient is bedridden, the percentage of odors that the staff involved in home medical care are concerned is urine odor 29%, body odor 13%, fecal odor 12%, halitosis 10%, and urine There is a strong demand for odor improvement.

  Urinary odor care is based on the rapid removal of urine that causes odor, but it is difficult to continue detailed and prompt treatment at all nursing care sites. The main cause of urine odor is ammonia odor which is generated when urine is left for a certain period of time while attached to clothes or a room. Since urine mixed with urine and feces emits a stronger ammonia odor than urine alone, more serious ammonia odor is generated from diapers commonly used in nursing care sites. Therefore, in order to reduce the mental burden caused by urine odor, it is desirable to focus on ammonia odor improvement.

  Methods for improving the urine ammonia odor have been studied. Odorless urine in urine is decomposed into the malodorous ammonia through the urease activity of microorganisms, so Patent Document 1 generates malodorous typified by flooring containing silver, copper and zinc powder, which are urease inhibitors. As a preventive member, Patent Document 2 provides a deodorizing spray and a cleaning agent that inhibit the growth of microorganisms in which a quinolone-based compound or a salt thereof has urease-producing ability. However, it is difficult to cover all living spaces where contact with urine is expected with deodorant processing materials, and it is a burden on caregivers to deodorize clothes and living spaces that have urine on them. large.

  Therefore, for the purpose of working on the human living environment and making it difficult for the discharged urine itself to generate an ammonia odor, Patent Document 3 discloses an oral consumption containing an aqueous extract of cinnamon, which exhibits inhibition of intestinal urease activity, as an active ingredient. Provides odorants. However, the oral preparation is a simple ingestion for healthy people, but is a dosage form that is difficult for ingestion by persons with dysphagia. Non-Patent Document 2 reports that the prevalence of dysphagia among medical care type beds, nursing care type beds, geriatric health facilities, and special nursing homes for the elderly exceeds 40%. In order to tackle the improvement of urine odor at a nursing care site, a method that can be used by people with dysphagia is necessary, and it is particularly desirable to expand non-invasive external preparations. Since urine odor is a chronic problem, it is ideal to develop a tape preparation with excellent sustained effect among external preparations.

  From the above, when aiming at urine odor improvement, the urine itself can have the effect of suppressing the generation of ammonia odor, and the transdermal absorption-type urine odor improvement tape that can be easily used by dysphagia among the care recipients Development of an agent was desired.

JP-A-5-137774 JP 2013-43861 A JP 2001-213794 A

2004 Home Health Care Grant Public Opening Completion Report (2006) Research project report on dysphagia (March 2012 National Longevity Medical Research Center)

  The present invention has been made in view of the above-described circumstances, and its purpose is to improve urine odor, and it is easy to use even if the cared person is a dysphagia person. It is to provide an improved tape.

As a result of diligent research to solve the above-mentioned problems, the present inventors have added a roasted rice bran extract as a urine odor improving substance to the tape preparation, whereby a transdermal absorption type urine odor improving tape having an urine odor improving effect. Based on this finding, the present inventors have completed the present invention.
That is, the present invention is shown in the following (1) to (3).
(1) A percutaneous absorption type urine odor containing a roasted rice bran extract as a urine odor improving substance and containing 0.1 to 20 w / w% of the roasted rice bran extract as a blending amount in the base Improvement tape agent.
(2) The percutaneous absorption type urine odor improving tape preparation according to (1), wherein the roasted rice bran extract improves ammonia odor of urine.
(3) The transdermal absorption urine odor improving tape preparation according to (1) or (2), wherein the blended amount of the roasted rice bran extract in the base is 1 to 10 w / w%.

  As described above, the present invention improves the urine odor itself by adding a roasted rice bran extract as a urine odor improving substance to the tape preparation, and is easy to use even if the cared person is a dysphagia person. A transdermal absorption urine odor improving tape can be provided.

FIG. 1 is a graph showing that the odor intensity of rat urine odor decreased with time when Example 1 was applied to a rat by applying it once a day for 2 days continuously. FIG. 2 is a graph showing that the pleasant / discomfort index of rat urine odor increased over time when Example 1 was applied to a rat for 2 days by reapplying once a day. FIG. 3 is a graph showing that the odor intensity of rabbit urine odor decreased with time when Example 2 was applied to a rabbit for 2 days by reapplying once a day. FIG. 4 is a graph showing that the pleasant / discomfort index of urine urine odor increased over time when Example 2 was applied to a rabbit for 2 days by reapplying once a day. FIG. 5 is a graph showing that the concentration of ammonia generated from rabbit urine decreased when Example 2 was applied to a rabbit for 2 days by reapplying once a day. It shows that the ammonia concentration on the second day decreased with a significant difference (p <0.05) compared to the 0th day.

  Hereinafter, the transdermal absorption urine odor improving tape of the present invention will be described in detail. Note that the examples described in the present specification do not particularly limit the present invention.

“Improvement of urine odor” in the present invention refers to a case where at least one of the following conditions (1) to (3) is satisfied.
(1) When a transdermal absorption urine odor improving tape is applied, in the sensory test for confirming the urine odor improvement effect on the collected urine, the evaluation standards of odor intensity are 0 points: odorless, 1 point: finally can be sensed Odor, 2 points: weak odor that shows what odor is, 3 points: odor that can be easily detected, 4 points: strong odor, 5 points: panelist's odor intensity average value before applying tape Compared with, it is reduced by one or more points.
(2) When the transdermal absorption urine odor improving tape was applied, in the sensory test for confirming the urine odor improving effect of (1) for the collected urine, the evaluation criteria for the comfort / discomfort index were -4 points: Extremely uncomfortable, -3 points: very uncomfortable, -2 points: uncomfortable, -1 point: somewhat uncomfortable, 0 points: neither pleasant nor uncomfortable, 1 point: somewhat pleasant, 2 points: pleasant, 3 points: very Pleasure, 4 points: When extremely pleasant, the panelist's pleasant / discomfort index average value is −1 or more.
(3) When a transdermal absorption urine odor improving tape was applied, the concentration of ammonia in urine volatile gas was significantly higher than that before applying the tape in the urine odor improvement effect confirmation device analysis test for collected urine. Decrease. Dunnett's method is used for the test.

  The blending amount of the roasted rice bran extract used in the transdermal absorption type urine odor improving tape of the present invention is not particularly limited, but should be in the range of 0.1 to 20 w / w% of the total blending amount of the tape base. Is preferable, and more preferably 1 to 10 w / w%. When the blending amount of the roasted rice bran extract is less than 0.1 w / w%, the effect of improving urine odor cannot be obtained sufficiently, which is not preferable. On the other hand, if the amount of the roasted rice bran extract is more than 20 w / w%, the fragrance of the roasted rice bran extract itself diffuses from the tape agent to the surroundings and is easily recognized by others.

  The transdermal absorption type urine odor improving tape of the present invention is a tape composed of three layers of a base, a support and a release material. The base used in the transdermal absorption urine odor improving tape of the present invention is prepared by a terpene resin or a non-aqueous adhesive as an adhesive compounding component.

  Examples of the terpene resin used in the present invention include YS resin, YS resin PX, YS resin PXN, YS polystar, Mighty ace, YS resin TO, YS resin TR, Clearon P, Clearon M, Clearon K, Dimaron, YS oil DA ( As described above, Yashara Chemical Co., Ltd.), Tamanoru 803L, Tamanoru 901 (above, Arakawa Chemical Industries, Ltd.) and the like can be mentioned, and these can be used alone or in combination of two or more.

  Although the compounding quantity of the terpene resin used for this invention does not have a restriction | limiting in particular, It is preferable to exist in the range of 10-20 w / w% of the whole tape agent base compounding quantity. When the blending amount of the terpene resin is less than 10 w / w%, sufficient tackiness cannot be obtained, and problems such as peeling off or peeling of the tape agent occur, which is not preferable. On the other hand, when the blending amount of the terpene resin is more than 20 w / w%, the adhesiveness to the skin is excessively increased, and physical irritation at the time of rash or peeling may occur, which is not preferable.

  Examples of the non-aqueous pressure-sensitive adhesive used in the present invention include a rubber-based pressure-sensitive adhesive and an acrylic pressure-sensitive adhesive.

  Examples of the rubber-based pressure-sensitive adhesive include natural rubber, synthetic isoprene rubber, styrene-isoprene-styrene rubber, styrene / butadiene rubber, styrene-butadiene-styrene rubber, polyisobutylene, polyisoprene, and polybutyl rubber. It can be used in combination of more than one species. The blending amount of the rubber-based pressure-sensitive adhesive is not particularly limited, but is preferably in the range of 25 to 35 w / w% of the total blending amount of the tape base. When the blending amount of the rubber-based pressure-sensitive adhesive is less than 25 w / w%, sufficient adhesiveness cannot be obtained, and problems such as peeling off and peeling of the tape agent occur, which is not preferable. Moreover, when there are more compounding quantities of a rubber-type adhesive than 35 w / w%, since the adhesiveness to skin increases excessively and a physical irritation | stimulation at the time of a rash and peeling may generate | occur | produce, it is unpreferable.

  As the acrylic pressure-sensitive adhesive, for example, the amount of alkyl (meth) acrylate having 4 to 14 carbon atoms in the alkyl group is in the range of 45 to 95 w / w% of the total amount of acrylic pressure-sensitive adhesive, and the amount of vinyl acetate An acrylic copolymer having a range of 5 to 55 w / w%. The blending amount of the acrylic pressure-sensitive adhesive is not particularly limited, but is preferably in the range of 70 to 95 w / w% of the total blending amount of the tape agent, and more preferably 75 to 90 w / w%. If the blending amount of the acrylic pressure-sensitive adhesive is less than 70 w / w%, sufficient adhesive strength cannot be obtained, which is not preferable. On the other hand, when the blending amount is more than 95 w / w%, the adhesiveness to the skin is excessively increased, and physical irritation at the time of rash or peeling may occur, which is not preferable.

  The percutaneous absorption type urine odor improving tape of the present invention, in addition to the above-mentioned essential components, various components that are acceptable in the production of pharmaceuticals within the range not impairing the effects of the present invention, that is, softeners, transdermal absorption An accelerator, an antioxidant and the like can be appropriately blended.

  Examples of the softening agent include liquid paraffin, polybutene, liquid polyisobutylene, castor oil, lanolin and the like, and can be used alone or in combination of two or more.

  Examples of the absorption promoter include l-menthol, 2-ethyl-1,3-hexanediol, glycols, fats and oils, polar solvents, and the like, and these can be used alone or in combination of two or more.

  Examples of the antioxidant include dibutylhydroxytoluene, ascorbic acid, tocopherol acetate and the like, and these can be used alone or in combination of two or more.

  The support used in the present invention preferably does not affect the release of rice bran extract. For example, polyethylene, polypropylene, polybutadiene, ethylene vinyl acetate copolymer, polyvinyl chloride, polyester, nylon, polyurethane and other synthetic resin films, Examples thereof include paper, cloth, and non-woven fabric, and a porous body, a foamed body, a woven cloth, and a non-woven fabric that are stretchable or non-stretchable used alone or in combination of two or more thereof can be used.

  Examples of the release material used in the present invention include polyethylene, polypropylene, polyester and other polymer material films, paper coated with silicone oil, and the like, and these can be used alone or in combination of two or more.

  When the thickness of the pressure-sensitive adhesive layer of the present invention becomes thin, it cannot contain the necessary amount of rice bran extract. Therefore, 10-300 micrometers is preferable.

  The transdermal absorption type urine odor improving tape preparation of the present invention can be produced by a conventionally known method of a tape preparation or a newly provided method. The method for producing the transdermal absorption urine odor improving tape of the present invention is not particularly limited as long as it undergoes a process of uniformly mixing the rice bran extract into the base, but a typical production method thereof is, for example, Examples thereof include a solvent method in which a rice bran extract and a base component are dissolved in an organic solvent to obtain a uniform dissolved product, and a hot melt method in which a rice bran extract and a base component are heated and mixed to obtain a uniform melt. The melt and melt obtained by these methods may be applied to the surface of an appropriate support, and a release material may be applied for the purpose of coating the base of the tape until use, and then cut into a desired shape.

EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to the examples.
Example 1
Based on the formulation shown in Table 1, it was prepared by the method of Preparation Method 1 to be described later to obtain a transdermal urine odor improving tape agent 1 of the present invention. As a result of conducting a sensory test for confirming the effect of improving the odor of rat urine alone according to Test Example 1 using the obtained transdermal absorption type urine odor improving tape agent 1, the odor intensity decreased by 1 or more and the pleasantness / discomfort index was -1. Since it was above, the urine odor improvement effect was confirmed. The results are shown in FIGS.

(Preparation method 1)
Acrylic adhesive solution (1) 39.5 g (acrylic adhesive 47.5% vinyl acetate solution), roasted rice bran extract (2) 0.2 g and 2-ethyl-1,3-hexanediol (3) 1 0.0 g was mixed and degassed. The obtained mixed solution was spread on a release material (Scotchpak1022, Fluorine-based release material, 3M Healthcare Co., Ltd.) so that the thickness of the base was 130 μm, and the exposed surface of the base facing the release material was spread. A polyethylene terephthalate knitted fabric (RD1723-2424, Aizet Co., Ltd.) was attached and thrown, and the base was dried at room temperature for 1 hour to obtain a transdermal absorption-type urine odor improving tape.

(Test Example 1)
Sensory test for confirming urine odor improvement effect in rats Using the transdermal absorption urine odor improving tape preparation of Example 1, a sensory test for confirming urine odor improvement effect was carried out by the following method.
Five Wistar 12-week-old rats (male) were raised in a metabolic cage (KN-646, Natsume Seisakusho Co., Ltd.) that can collect feces and urine separately, and urine was collected in an Erlenmeyer flask continuously for 12 hours. did. Panelists (two men) sniff the collected urine and scored the odor intensity and the comfort / discomfort index simultaneously according to the criteria described below, and the average value was taken as the value on Day 0.
Next, Example 1 (applied area 16 cm ² , roasted rice bran extract amount 0.03 mg equivalent) was applied to the abdomen of the rat. Rats were bred in metabolic cages and continued from 12 hours to 24 hours after application (corresponding to day 1), and urine was collected in Erlenmeyer flasks. 24 hours after application Example 1 was peeled off, new Example 1 was applied to the abdomen, and again from 12 hours to 24 hours (from 36 hours to 48 hours after the first application, corresponding to the second day) Urine was collected continuously. Panelists sniffed the urine odors on the 1st and 2nd days immediately after collection, and scored the odor intensity and pleasantness / discomfort index simultaneously according to the aforementioned criteria. By comparing the average value with the value on the 0th day, a sensory test for confirming the effect of improving odor of urine alone was made.
[Scoring criteria]
Odor intensity 0 points: No odor 1 point: Finally, a perceivable odor 2 points: A weak odor that understands what kind of odor 3 points: Easily perceived odor 4 points: A strong odor 5 points: A strong odor
Pleasure / discomfort index: -4 points: Extremely unpleasant -3 points: Very uncomfortable-2 points: Uncomfortable -1 point: Slightly uncomfortable 0 points: Not pleasant or uncomfortable 1 point: Slightly pleasant 2 points: Pleasant 3 points: Very pleasant 4 points: Extremely pleasant

(Example 2)
In Example 1, the amount of the roasted rice bran extract (2) was increased from 0.2 g to 2.0 g, and the acrylic pressure-sensitive adhesive (1) was increased from 39.5 g to 35.7 g (corresponding to 17.0 g of the acrylic polymer). The same preparation method as in Example 1 was repeated except that the amount was reduced to 2 to obtain a transdermal urine odor improving tape preparation 2 of the present invention. As a result of conducting a sensory test for confirming the effect of improving urine odor derived from rabbit manure according to Test Example 2 using the obtained transdermal absorption-type urine odor improving tape agent 2, the odor intensity decreased by 1 or more, and the comfort / discomfort index was- Since it was 1 or more, the urine odor improving effect was confirmed. The results are shown in FIGS. Furthermore, as a result of carrying out a device analysis test for confirming the effect of improving urine odor derived from rabbit manure according to Test Example 3 using the transdermal absorption-type urine odor improving tape agent 2, since the ammonia concentration in urine volatile gas was significantly reduced, the urine odor was improved. The effect was confirmed. The results are shown in FIG.

(Test Example 2)
Sensory test for confirming the effect of improving urine odor derived from rabbit manure The sensory test for confirming the effect of improving urine odor was carried out by the following method using the transdermal absorption urine odor improving tape of Example 2.
Japanese white species (Kbs: JW) 21-23 weeks old rabbits (male) 4 were raised in cages (KN-789, Natsume Seisakusho Co., Ltd.) and continued for 12 hours for manure (urine = urine + feces) Collected in a metal tray. Panelists (2 men) sniffed urine immediately before the evaluation, scored the odor intensity and pleasantness / discomfort index simultaneously according to the criteria of Test Example 1, and set the average value as the value on the 0th day.
Next, Example 2 (applied area: 70 cm ² , roasted rice bran extract amount: 1.4 mg equivalent) was applied to the back of the rabbit. Rabbits were raised in cages, and urine mixed with feces was collected in a metal tray continuously from 12 hours to 24 hours after application (corresponding to the first day). 24 hours after application Example 2 was peeled off, new Example 2 was applied to the abdomen, and again after 12 hours to 24 hours (from 36 hours to 48 hours after the first application, corresponding to the second day) Urine was collected continuously. The panelists sniffed the urine odor on day 1 and day 2 immediately after collection, and scored the odor intensity and pleasantness / discomfort index simultaneously according to the criteria of Test Example 1. By comparing the average value with the value on the 0th day, it was set as a sensory test for confirming the effect of improving urine odor derived from rabbit manure.

(Test Example 3)
Rabbit urine-derived urine odor improvement effect confirmation device analysis test 500 μL each of the rabbit urine samples on Day 0 and Day 2 of Test Example 2 were added to a 500 mL glass bottle filled with nitrogen gas and sealed. The glass bottle was allowed to stand at 50 ° C. for 20 minutes, and then allowed to stand at room temperature for 30 minutes to reach room temperature. 100 mL of the gas inside the glass bottle was sucked with a gas detector (GV-100S, Gastec Co., Ltd.) equipped with a gas detector tube (3 L ammonia / KN3165176, Gastec Co., Ltd.), and obtained on the 0th and 2nd days. By comparing the average value of ammonia concentration, it was set as a device analysis test for confirming the effect of improving urine odor derived from rabbit manure.

  The transcutaneous absorption type urine odor improving tape of the present invention can give the urine itself an effect of suppressing the generation of ammonia odor and can be easily used by dysphagia among care recipients. The present invention relates to an improvement tape agent, which can be sufficiently used in industry.

Claims (3)

  A transdermal absorption type containing a roasted rice bran extract as a urine odor improving substance, wherein the roasted rice bran extract is contained in an amount of 0.1 to 20 w / w% in the base Urinary odor improving tape.   The transcutaneous absorption type urine odor improving tape preparation according to claim 1, wherein the roasted rice bran extract improves ammonia odor of urine. The percutaneous absorption type urine odor improving tape preparation according to claim 1 or 2, wherein the amount of the roasted rice bran extract in the base is 1 to 10 w / w%.

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