JP2014103900A5 - - Google Patents

Claims (12)

  DNA encoding at least one protein selected from the group of neurodegenerative disease-related proteins consisting of amyloid β protein, tau protein, α synuclein, SOD1, TLS, TDP-43, huntingtin and prion protein, at least one length A recombinant vector comprising a DNA encoding a linker sequence having any amino acid sequence and a DNA encoding a fluorescent protein. A transgenic non-human animal into which the recombinant vector according to claim 1 has been introduced. The animal according to claim 2 , wherein the non-human animal is a mouse. A transgenic nematode into which the recombinant vector according to claim 1 has been introduced. A transformed cell into which the recombinant vector according to claim 1 has been introduced. A neurodegenerative disease model animal comprising the non-human transgenic animal according to claim 2 . A neurodegenerative disease model nematode comprising the transgenic nematode according to claim 4 . A neurodegenerative disease model cell comprising the transformed cell according to claim 5 . The animal according to claim 6 , wherein the neurodegenerative disease is Alzheimer's disease. The nematode according to claim 7 , wherein the neurodegenerative disease is Alzheimer's disease. The cell according to claim 8 , wherein the neurodegenerative disease is Alzheimer's disease. A test substance is administered to the neurodegenerative disease model animal according to claim 6 or 9 , the neurodegenerative disease model nematode according to claim 7 or 10 , or the neurodegenerative disease model cell according to claim 8 or 11. Inoculating, detecting the neurodegenerative disease-related protein in the model animal, model nematode or model cell after administration of the test substance or inoculation, and selecting a therapeutic agent for the neurodegenerative disease using the detection result as an index, A screening method for therapeutic agents for neurodegenerative diseases.