JP2014084176A - Cold insulation container - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cold insulation container capable of protecting a medical product, a chemical product, a cell or the like to be placed under a strict temperature control condition from the influence of an external temperature environment or movement at a temperature in a fixed range for a prescribed time.SOLUTION: A cold insulation container is formed in a double shell structure of an outer container and an inner container to improve shock resistance performance and heat insulating performance. In the inner container body, such products as medical products, chemical products or cells are stored in the center. In a side face, a cold storage material side face installation container including cold materials is disposed. In a bottom surface, a cold storage material bottom surface installation container is disposed. In a top surface, a platelike cold storage material is disposed. By the structure covering the entire part of the medical products, the chemical products, the cells or the like, the products are protected from the influence of an external temperature environment or movement at a temperature in a fixed range for a prescribed time.

Description

  The present invention relates to a cold storage container, and more particularly to a cold storage container that can protect pharmaceuticals, chemicals, cells, and the like from effects caused by an external temperature environment and movement for a certain time at a certain temperature range.

  Some pharmaceuticals, chemicals, cells, etc. (hereinafter sometimes referred to as “temperature controlled objects”) are stored and moved within research institutions, and transported and stored to other research institutions and hospitals and universities. In many cases, it is required to hold at a certain range temperature for a certain period of time.

  As a method for this, the heat storage material and the cold insulation container are efficiently heat-exchanged so that the material with high thermal conductivity is in contact with the cold storage material, and the temperature deviation is suppressed by covering the whole with the material with high thermal conductivity. Has been proposed (Patent Document 1).

  In addition, a method has been proposed in which precise temperature management is performed at a constant temperature range by combining two or three types of cold storage materials having different phase change temperatures (Patent Document 2).

JP 2011-46449 A JP 2011-51632 A

  However, the cold storage material for hard resin molded products used for these requires the production of a mold in accordance with the shape of the temperature control object, and there is a problem that the price is high. On the other hand, in the case of soft resin film regenerator materials, when precise temperature control is required, it is necessary to mold in advance to cover the object of temperature control before freezing. Since the entire object is not covered, the temperature management object is not suitable for long-term position and temperature maintenance, and depending on how it is handled, the contents of the cold storage material leak easily and the temperature management object is contaminated. was there.

  The present invention has been made in view of the above circumstances, and the purpose thereof is a temperature at which the quality is remarkably deteriorated even by slight temperature fluctuations by making the regenerator material in a constant shape and covering the entire temperature management object. An object of the present invention is to provide a cold container capable of protecting a temperature management object having severe management conditions from an influence caused by an external temperature environment or movement at a certain range temperature for a certain time.

  In order to solve the above-mentioned problems, the present invention has a double shell structure of an outer container and an inner container, and the outer container has a heat insulation and impact resistance by using a flexible material, and a lid that can be opened and closed at the top. The outer container and the inner container are occluded at a fixed position with a space, and the inner container is insulated by using foamed polyurethane or a reduced vacuum degree inside and using a hard material such as metal outside. The inside of the inner container body is centered on the object to be temperature controlled, and the side is made of metal with high thermal conductivity and contains heat storage material on the side. A container for installing a bottom-side regenerator material that uses a flexible shock-absorbing material with vibration resistance and impact resistance, and a material that hardens the top and bottom surfaces and has strength that does not deform. A plate-shaped cold storage material that covers the entire top surface of the temperature control object is placed on the top surface. And it has a structure there. Accordingly, the present invention resides in a cold container that protects a temperature management object from an influence caused by an external temperature environment or movement at a certain range temperature for a certain time.

  According to the cold insulation container according to the present invention, the temperature management object having severe temperature management conditions in which the quality is remarkably deteriorated even by a slight temperature fluctuation by keeping the cold storage material in a certain shape and covering the entire temperature management object. Can be protected from the influence of external temperature environment and movement for a certain time at a certain range temperature. Moreover, by storing the cool storage material on the upper surface in the cool storage material container and using it, it is expected that the contamination of the temperature control object can be suppressed even if the contents of the cool storage material leak.

The perspective view which shows the structure of the principal part of a cold storage container. The graph which shows the temperature transition of the measurement example inside a cold storage container.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings, but the present invention is not limited thereto.

  FIG. 1 is a perspective view showing the structure of a cold storage container, which has a double shell structure of an outer container 1 and an inner container 2 in order to improve impact resistance and heat insulation performance. The structure is such that the cool storage material 18 alone, the cool storage material 18 and the cool storage material side surface installation container 19, the combination of the cool storage material 18 and the cool storage material bottom surface installation container 20, and the temperature management object container 3 are accommodated. The container for temperature management object 3 may be a container in which medicines, chemicals, cells or the like are previously placed in a storage container, or a container that is packaged with a film or the like.

  The outer container 1 has an outer container handle 7 and an outer container shoulder strap 6 attached to an outer container body 5. The outer container 1 has an outer container lid 4 at the top, and can be opened and closed. A bottom support plate 10 provided with a bottom support plate recess 11 is accommodated on the bottom surface inside the outer container body 5 so that the bottom of the inner container 2 is assembled so that the inner container 2 does not move. An upper support plate 8 provided with an upper support plate recess 9 is accommodated in the upper portion so that the upper portion of the inner container 2 is assembled. The material of the upper support plate 8 and the bottom support plate 10 is a flexible cushioning material, for example, foaming. Polystyrene is used. The outer container 1 is made of a material obtained by laminating and sewing water-repellent or waterproof sheets on both sides of the flexible sheet. is there. Examples of the water-repellent or waterproof sheet include polyethylene and polyester.

  An inner container handle 17 is attached to the inner container 2 so that it can be easily moved to a cylindrical bottomed inner container body 15 having a heat insulation structure of a double shell structure, and the inner container lid 12 can be removed at the upper part. When the inner container fastener 16 for fixing the inner container lid 12 is attached and the inner container main body 15 and the inner container lid 12 are combined to form the inner container 2, the airtightness inside the inner container 2 is improved. A packing 14 for maintaining is sandwiched between the inner container body 15 and the inner container lid 12, and a thermometer installation recess 13 is provided inside the inner container lid 12. The heat insulating structure of the inner container body 15 is preferably a vacuum heat insulating structure, but may be a simple double shell structure having a foaming heat insulating material or an air layer.

  The cold storage material 18 is a combination of the cold storage material 18 alone, the cold storage material 18 and the cold storage material side surface installation container 19, and the cold storage material 18 and the cold storage material bottom surface installation container 20. The entire bottom surface is covered and disposed inside the inner container 3 without a gap. The cold storage material side surface installation container 19 and the cold storage material bottom surface installation container 20 have a structure in which the cold storage material 18 is accommodated in each, and even when the cold storage material 18 melts, the container shape does not change and the container 3 for the temperature management object. The close contact state can be maintained. The material for the cold storage material side surface installation container 19 and the cold storage material bottom surface installation container 20 is preferably made of a metal such as stainless steel that has strength and is relatively easy to process and resistant to corrosion. A resin material such as plastic may be used. If the material can maintain strength, the contact surface with the temperature control object container 3 is made of a material having high thermal conductivity, and the contact surface with the inner container 2 is thermally conductive. A combination of materials having a low rate may be used. Further, the cool storage material 18 on the upper surface of the temperature management object container 3 used alone may be put in a container having a structure in which the contents of the cool storage material 18 are not leaked, similar to the cool storage material bottom surface installation container 20.

  The content of the regenerator 18 is a 0 ° C. melting point with water or the like as a main component and added with a superabsorbent polymer, preservatives, stabilizers, etc., and dissolves inorganic salts such as sodium chloride, ammonium chloride and potassium chloride in water. Examples include types exceeding 0 ° C. such as tetrabutylammonium bromide (hereinafter sometimes referred to as TBAB), paraffin, capric acid (fatty acid), sodium thiosulfate (inorganic hydrate), etc. .

  Hereinafter, the temperature holding test using the cold insulation container sample of the present invention will be described with reference to Examples, but the present invention is not limited thereto. The cold insulation container sample was manufactured according to the specifications shown in the following table.

保冷容器サンプルに使用した温度管理対象物用容器３として、直径１４０ｍｍ、高さ１１０ｍｍの金属製の容器を使用した。本試験は温度管理対象物用容器３が４℃±１℃の温度範囲を保持する条件として試験を実施し、蓄冷材１８は融解温度３℃のＴＢＡＢを主成分とした液状組成物をポリエチレン製の袋高さ１７０ｍｍ、幅１７０ｍｍに充填したものを使用し、重量は１袋あたり７５０ｇであった。

A metal container having a diameter of 140 mm and a height of 110 mm was used as the temperature control object container 3 used for the cold insulation container sample. This test was conducted under the condition that the temperature control object container 3 maintained a temperature range of 4 ° C. ± 1 ° C., and the regenerator 18 was made of polyethylene with a liquid composition mainly composed of TBAB having a melting temperature of 3 ° C. A bag with a height of 170 mm and a width of 170 mm was used, and the weight was 750 g per bag.

  The outer container 1 and the inner container 2 were left open for 2 hours or more in a room where the room temperature was set to 25 ° C. The temperature management object container 3 has two temperature measurement points 1 and 2 at the diagonal position of the inner surface height of about 50 mm of the temperature management object container 3, and the temperature management object container 3. After two points, measuring point 3 and measuring point 4, are attached to the diagonal position with an outer surface height of about 50 mm, the internal temperature is set to 3 ° C. until the temperature of the temperature management object container 3 reaches 3 ° C. Cooled well in the refrigerator. Four cold storage material side surface installation containers 19 each containing one cold storage material 18, one cold storage material bottom surface installation container 20 containing one cold storage material 18, and one plate of the cold storage material 18 The pieces were frozen in a freezer at −20 ° C. for one day, then transferred to a refrigerator set at a temperature of 3 ° C. and stored for 12 hours or more, and the temperature of the cold storage material 18 was kept at 3 ° C. while keeping the frozen state.

  In the measurement, one of the regenerator material 18 that has been in the above-mentioned state in a room at room temperature of 25 ° C. is placed in the regenerator material bottom surface installation container 20 in the inner container 2, and the regenerator that has been in the above-described state is placed on it. Four of the materials 18 placed in the cold storage material side surface installation container 19 are installed in an annular shape, and the temperature control object container 3 in the above-described state is loaded in the center thereof, and the above-described state is provided thereon. The plate-shaped thing of the cool storage material 18 which became this was arrange | positioned, and the inner container lid | cover 12 of the inner container 2 and the outer container lid | cover 4 of the outer container 1 were immediately closed. And when temperature change was confirmed with the temperature sensor attached to the container 3 for temperature management objects, temperature transition as shown in the graph of FIG. 2 is seen, and the measurement points 1-4 of the container 3 for temperature management objects are seen. The time required for all the temperatures to exceed 4 ° C. ± 1 ° C. was 19 hours or more.

  As described above, the present invention is a pharmaceutical, chemical, cell, or the like that has severe temperature control conditions such that quality is significantly deteriorated even by slight temperature fluctuations by keeping the regenerator material in a fixed shape and covering the entire temperature control object. Thus, it is possible to provide a cold storage container that can be protected from the influence caused by the external temperature environment and movement for a certain time at a certain range temperature.

DESCRIPTION OF SYMBOLS 1 Outer container 2 Inner container 3 Temperature control object container 4 Outer container lid 5 Outer container body 6 Outer container shoulder strap 7 Outer container handle 8 Upper support plate 9 Upper support plate recess 10 Bottom support plate 11 Bottom support plate recess DESCRIPTION OF SYMBOLS 12 Inner container lid 13 Thermometer installation hollow 14 Packing 15 Inner container main body 16 Inner container fastener 17 Inner container handle 18 Cold storage material 19 Cold storage material side surface installation container 20 Cold storage material bottom surface installation container

Claims (6)

  A cold storage container that contains both cold storage materials and temperature control objects such as pharmaceuticals, chemicals, and cells, and holds the temperature control object at a certain range of temperature, and has a double shell structure of an outer container and an inner container. A flexible bottom support plate and top support plate are housed in the inner container bottom and top so that the inner container does not move. Vibration-proof material with a container for side installation of the regenerator material that has a shape that is in close contact with the temperature control object that contains the material, and sandwiched between the upper and lower surfaces containing the regenerator material with a material that is hard and does not deform It has a structure in which a container for installing the bottom surface of the cold storage material of flexible cushioning material with heat resistance and impact resistance is arranged, and a plate-shaped cold storage material covering the entire top surface of the temperature control object is arranged on the top surface. Contents of temperature management object and cold storage material with the container and inner container lid open Cold container, characterized in that arranged to be out directly from above.   The cold storage container according to claim 1, wherein the outer container is a flexible foamed resin material covered with a water-repellent or waterproof sheet-like material.   The cold storage container according to claim 1 or 2, wherein the material constituting the inner container is a metal plate or a composite material obtained by laminating a resin and a foamed resin, and at least an outer surface of the inner container is composed of a metal plate.   The cold storage container according to claim 1 or 2, wherein the material constituting the inner container is a composite material in which a metal plate or a resin is laminated, and the vacuum degree of the intermediate layer is increased.   The cold storage container according to any one of claims 1 to 4, wherein the cold storage material used in the inner container is placed in a container that is a metal or resin material capable of fixing the shape in advance.   The outer container is flexible and has a portable handle and shoulder strap, and the upper part can be opened and closed with a lid, and the inner container has a heat-insulating lid structure with a portable handle and upper part that can be removed by a fastener. The cold storage container according to claim 1, which has.

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