JP2014073210A - Patch - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a patch including a three-division type release liner, capable of preventing unnecessary adhesion between central portions of an adhesive layer.SOLUTION: A patch includes: a support body; and a release liner laminated on the support body through an adhesive layer. The release liner is divided into three of a central release part, a left side release part, and a right side release part in the width direction by two cutting lines for cutting-off formed in an intersection direction intersecting the width direction, lateral sides on the central release part side of each of the left side release part and right side release part are respectively formed with left side projecting parts and right side projecting parts alternately along the intersection direction, and a part of a tip part of each left side projecting part is formed on the right side with respect to a part of a tip part of each right side projecting part adjacent in the intersection direction, in the width direction.

Description

  The present invention relates to a patch. More specifically, the present invention relates to a patch comprising a three-part release liner and excellent in operability at the time of sticking.

  Conventionally, a drug-containing patch has been adopted as a means for administering a drug into a living body. The drug-containing patch is obtained by laminating a pressure-sensitive adhesive layer containing a transdermal drug and a release liner covering the pressure-sensitive adhesive layer on one side of a support made of a nonwoven fabric or the like.

  In general, such a drug-containing patch is often affixed to an uneven part on the surface of the body or a bent part such as an indirect peripheral part. Therefore, an extremely flexible member is preferably used as the support. It is done.

  However, the adhesive patch using such a flexible support, when applied to the affected area, the support easily bends and the adhesive surfaces stick together, making it difficult to apply, or In many cases, a part of the patch is stuck in a wrinkle state, and such poor operability at the time of sticking has been a problem.

  Therefore, as a means for improving the operability at the time of application of the patch, a three-part type release in which the release liner is divided into three by providing two straight cut lines in the center of the release liner in parallel. Patches with a liner have been proposed. When the patch is applied to the affected area, only the central part of the release liner is peeled off from the support first, and the adhesive part in the central part is pressed to the affected area. Patches that are improved in operability at the time of application have been widely used by applying them and then peeling off the release sheets on both sides to apply the entire patch.

  However, even in the case of a patch comprising such a three-part release liner, it is still supported after the central part of the release liner is peeled off until the patch is completely applied to the affected area. There is a problem that the adhesive surfaces at the center of the body stick to each other, and even in a patch including a three-part type release liner, further improvement in operability at the time of application has been demanded.

  In this regard, when the release liner is peeled off, the central portion of the release liner is limited to a certain range so that the adhesive layers do not adhere to each other, and further, a broken line is provided in parallel with the cut line so A patch with improved operability has been proposed (see Patent Document 1).

JP 2002-306530 A

  However, the patch described in Patent Document 1 is limited in the width of the central portion, so that the central portion is first pressed onto the affected area and temporarily adhered to the affected portion. It may not be sufficient to prevent the adhesive layers from adhering to each other after the central part of the release liner has been peeled off until it is temporarily attached to the affected area. It was.

  The present invention has been made in view of the above circumstances, and when a patch comprising a three-part type release liner is applied to an affected area, after peeling the central part of the release liner, the central part is used as the affected part. It is an object of the present invention to provide a patch that can sufficiently prevent the central portions of an adhesive layer from adhering to each other before temporary sticking.

  In the patch comprising a three-part type release liner, the shape of the side part on the center side of the side part on both sides of the release liner includes a convex part for preventing the support from warping. As a result, it was found that unnecessary adhesion between the central portions of the adhesive layer after peeling of the central portion of the release liner can be prevented, and the present invention has been completed. More specifically, the present invention provides the following.

(1) a support;
A release liner laminated via an adhesive layer on the support,
The release liner is divided into a central release portion, a left release portion, and a right release portion in the width direction by two cut lines formed in a crossing direction that intersects the width direction. ,
Depending on the shape of the cutting line, left side convex portions and right side convex portions are alternately formed along the intersecting direction on the side sides of the left side peeling portion and the right side peeling portion on the side of the central peeling portion, respectively. And
A patch in which, in the width direction, a part of the protruding end portion of the left convex portion is formed on the right side of a portion of the protruding end portion of the right convex portion adjacent to the crossing direction.

  According to the invention of (1), in a patch comprising a three-part type release liner with high operability at the time of application, adjacent convex parts formed on the left side release part and the right side release part are fitted together. Be placed. Thereby, adhesion of the adhesive layer center part by the support body twisting after the center peeling part peeling and before sticking to an affected part can fully be prevented by the rigidity of adjacent convex parts.

  (2) The patch according to (1), wherein each of the left peeling portion and the right peeling portion has a plurality of convex portions.

  According to the invention of (2), by forming a plurality of support auxiliary convex portions on both the left and right peeled portions, the effect of preventing the wobbling of the support is improved, and the adhesion of the adhesive layer is more enhanced. It can be surely prevented.

  (3) The patch according to (1) or (2), wherein each of the convex portions is an arc.

  According to the invention of (3), the tension related to the central portion of the pressure-sensitive adhesive layer can be evenly dispersed after the central peeling portion is peeled off until the sticking is completed. As a result, the above-described kinking prevention effect is further enhanced. Further, the convex portion is easily lifted from the adhesive layer, and the effect as a knob is enhanced.

(4) The support has a rectangular shape having a long side and a short side,
The patch according to any one of (1) to (3), wherein the central peeling portion has a cocoon shape that advances while meandering left and right between the long sides of the support.

  According to the invention of (4), the area of the adhesive layer corresponding to the central exfoliation part of the adhesive layer can be increased by making the central exfoliation part meandering, and thereby the adhesive force to the affected part can be increased. Thereby, patch stability at the time of temporary sticking by the center part can be raised moderately, and, therefore, operativity at the time of sticking of a patch can be improved.

  (5) The patch according to (4), wherein the wrinkle width of the wrinkle shape is 3 mm or more, and the wrinkle distance is 105% or more and 300% or less of the linear distance of the short side.

  According to the invention of (5), since the heel width and the heel distance are within the above ranges, the adhesive force to the affected part can be increased, and the adhesive layer due to the above support being twisted. Adhesion between the central portions can be sufficiently prevented. Note that the heel width means the shortest distance between the two cutting lines, and the heel distance means the shorter one of the distances between the two cutting lines.

  (6) The center peeling portion is formed so as to straddle the center line in the short side direction that equally bisects the long side direction, and both the left convex portion and the right convex portion straddle the center line. The patch according to (4) or (5).

  According to the invention of (6), when the center peeling portion is peeled off and then applied while applying tension from the left and right directions to the support of the patch of the present invention, the central portion can be evenly tensioned. . Thereby, the exact sticking operation | work to the desired position of a patch becomes easier.

  (7) The right side peeling part and the left side peeling part are formed with bending auxiliary lines for raising a part of the right side peeling part and the left side peeling part near the central peeling part (1) to (6 ).

  According to the invention of (7), by raising a part of both the left and right peeled portions, it becomes easy to apply to the affected part without forming wrinkles to every corner of the patch.

  According to the present invention, in a patch provided with a three-part type release liner that is excellent in operability at the time of application, an unnecessary adhesion between the central portions of the adhesive layer is sufficiently high by a simple configuration change. Can be prevented. Therefore, the operability of the patch comprising the three-part release liner can be further improved at low cost.

It is a perspective view which shows the whole structure of the patch of this invention. It is a top view of the release liner of the patch of the present invention. It is a top view of the conventional 3 division type release liner.

  Hereinafter, an embodiment of the present invention will be described with reference to the drawings.

  FIG. 1 is a perspective view of a patch 1 according to an embodiment of the present invention. The patch 1 is laminated so as to cover the entire surface of the support 2 with the support 2 being a sheet-like base material, an adhesive layer (not shown) containing a drug on the support 2 and the adhesive layer. A release liner 3. In addition, as a form of the patch provided by the present invention, a poultice, a plaster, a tape, a plaster and the like can be mentioned.

  In the patch 1, the release liner 3 includes a left side release part 31, a right side release part 32, and a center release part 33, which are three divided parts. The patch 1 greatly improves the operability at the time of application by limiting the shapes of the left peeling part 31, the right peeling part 32, and the central peeling part 33 to shapes unique to the present application. is there. Hereinafter, first, the release liner 3 which is a characteristic constituent element of the patch 1 and each of its constituent parts will be described in detail, and then other constituent elements will be described.

[Release liner]
The material of the release liner 3 is a material that is impermeable to drugs and water in order to stably maintain the components of the patch, and can be easily peeled off from the adhesive layer. What is necessary is just to have the rigidity of the grade which can show a fixed effect in order to prevent the support body 2 from shaking after peeling of the part 33. FIG. Specifically, a film formed of one selected from the group consisting of polymer films such as polyethylene, polypropylene, polyethylene vinyl acetate, polyethylene terephthalate, metal foils such as aluminum and zinc, paper, and fibers, or the above group A laminate film in which two or more kinds of materials selected from the above are laminated is mentioned. A thin coating film of silicon or the like may be applied to the surface of the release liner 3 that is bonded to the adhesive layer.

  As shown in FIGS. 1 and 2, the release liner 3 has three parts, that is, a left side release by two cutting lines C <b> 1 and C <b> 2 connecting a pair of two long sides facing each other. It is divided | segmented into the part 31 and the right side peeling part 32, and the center peeling part 33 clamped by those both sides parts.

In this embodiment, as shown in FIG. 2, two cutting lines C <b> 1 and C <b> 2 are formed substantially in parallel. As a result, the central peeling portion 33 sandwiched between C <b> 1 and C <b> 2 is exactly the center line l. _It has a bowl shape that advances while meandering from side to side between the long sides.

  In this specification, the case where the patch is a rectangle composed of one set of long sides and another set of short sides and a shape similar thereto is described, and the line connecting the centers of the long sides is centered. One short side of the line or patch is referred to as the left side, and the other short side is referred to as the right side. The long side direction corresponds to the width direction in the present invention, and the short side direction corresponds to the cross direction in the present invention (however, the cross direction is not limited to the orthogonal direction in the width direction).

As shown in FIG. 2, the left side peeling section 31 to the cutting lines C1 and one of the sides is the cutting line C1 to the side of the center line l ₁ near side of the patch, at substantially equal intervals semielliptical A plurality of left convex portions 312 are formed. The shape of the left convex portion 312 may be an elliptical shape as shown in FIG. 2 or a polygonal protruding portion such as a tapered convex portion, but an arc shape is preferable. And the right side convex part 322 which makes the cutting line C2 one side is formed in the position adjacent to the short side direction (crossing direction) of the left side convex part 312. As shown in FIG. In this embodiment, the left convex portion 312, the right convex portion 322, the left convex portion 313, and the right convex portion 323 are alternately arranged in the short side direction, and a bowl-shaped central peeling portion is provided between the convex portions. 33 is formed.

In terms of the relationship between the left bent portion 312 and the right projecting portion 322 adjacent, as shown in FIG. 2, in this embodiment, the projecting end 312a of the left bent portion 312, beyond the center line l _1, the center line Projecting to the right. On the other hand, the protruding end portion 322a of the right protrusion 322, also beyond the center line l _1, are formed to protrude to the left of the center line. That is, in the long side direction (width direction), the protruding end portion 312a is formed so as to be always located relatively closer to the right side than the protruding end portion 322a, and arranged so that two adjacent convex portions are engaged with each other. Is done.

  When the patch 1 is applied to the affected part, only the central peeling part 33 is peeled from the support 2 while the left peeling part 31 and the right peeling part 32 remain attached to the support 2. And by sticking the center part of the adhesion layer exposed by peeling of the center peeling part 33 to an affected part, exact and stable sticking of the patch 1 is achieved. At this time, since the rigidity of adjacent convex portions interferes with each other, the central portion of the adhesive layer generated by the support 2 being twisted after being peeled from the central peeling portion 33 and before being attached to the affected area It is possible to effectively prevent the problem of adhesion.

FIG. 3 shows a conventional three-part patch. In this conventional patch, a central peeling portion 53 exists between the left peeling portion 51 and the right peeling portion 52 via cutting lines 512 and 522. In this case, the cutting lines 512 and 522 are meandering respectively, the shape of the central stripping portion 53 is not turned ridge shape as a whole, on the center line I _2, left peeling section 51 and the right side peeling section 52 None of the protrusions are disposed across the protrusions.

  In the case of such a conventional technique, in order to obtain the required adhesion at the time of temporary attachment, the area of the central peeling portion that defines the exposed portion of the adhesive layer at the time of temporary attachment is required to have a predetermined area. It is done. Specifically, it has been conventionally desired that the average distance between the two cutting lines 512 and 522 be about 20 mm or more. However, on the other hand, in order to prevent unnecessary sticking between the adhesive layers, for example, there is a request to make the distance between the cutting lines 512 and 522 as small as possible. From this viewpoint, the average of the two cutting lines is required. It was desirable that the interval be within about 15 mm. Since both conflicting requirements cannot be satisfied, the conventional product adopts a configuration that sacrifices either the adhesive stability during temporary attachment or the unnecessary sticking prevention of the adhesive layer. It was.

  However, the patch 1 of the present invention does not require the interval between the cutting lines C1 and C2, that is, the width of the central peeling portion, by making the shape of the central peeling portion 33 as the specific hook shape as described above. The adhesive stability at the time of the temporary attachment is enhanced by narrowing it within a certain range in order to prevent sticking, and by setting it to a certain width or more that can ensure the above-mentioned adhesion stability. . Specifically, the width of the center peeling portion 33 is not less than 3 mm and not more than the length of the long side, and more preferably not less than 5 mm and not more than 20 mm. Further, the heel distance of the central peeling portion 33 is preferably 105% or more and 300% or less of the straight distance of the short side, more preferably 110% or more and 210% or less, and further preferably 140% or more and 160% or less. And most preferably 150%.

  In the present invention, the relative positional relationship between the protruding end portion 312a and the protruding end portion 322a in the left-right direction is independent of the position of the center line, and is a virtual straight line in the short side direction positioned across the central peeling portion 33. On the other hand, the protruding end portion 312a may be formed so as to be always positioned relatively closer to the right side than the protruding end portion 322a.

  Further, the protruding end 312a and the protruding end 322a also function as a knob when the left peeling portion 31 and the right peeling portion 32 are peeled thereafter.

  Furthermore, in the above, the case where the cutting lines C1 and C2 forming the left peeling part 31, the right peeling part 32, and the central peeling part 33 are composed of meandering curves has been described, but the shapes of the cutting lines C1 and C2 are the same. For example, a continuous mountain shape or a sawtooth shape may be used as long as the shape and positional relationship of each part can be within the above-described range.

  Further, as shown in FIG. 2, the release liner 3 is formed with polygonal lines 311 and 321 formed linearly in the same direction as the cutting lines C1 and C2 on the outer sides near the both sides of the cutting lines C1 and C2, respectively. It is preferable. The polygonal lines 311 and 321 may be perforated lines, line lines, or other polygonal line processing, and are not particularly limited as long as the polygonal line portion is processed to facilitate the folding of the release liner. The broken lines 311 and 321 facilitate the standing of the both-side peeled portion, and in addition to the above-described effects, the operability when applying the patch 1 can be further improved.

[Support]
The support 2 may be made of a material that is substantially impermeable to a liquid or gel-like drug and that can follow the movement of the skin or mucosal surface. For example, stretchable or non-stretchable woven fabrics, fabrics such as non-woven fabrics, or films of polyethylene terephthalate, polyethylene, polypropylene, ethylene vinyl acetate copolymer, vinyl chloride, and the like may be used alone. Or what laminated | stacked multiple types may be used. Among these, the material of the support 2 is less painful to the user during use, preferably has excellent handling properties, and more preferably is inexpensive.

  In the present invention, a support that has been conventionally difficult to use because it is flexible and has no rigidity or stiffness, and the central part of the adhesive layer tends to adhere to each other at the time of application, such as a nonwoven fabric. However, a relatively weak material manufactured by the melt blow method, a weak film with a thickness of less than 50 μm made of polyester, polypropylene, etc., other woven fabrics, knitted fabrics, papers, or laminates thereof, However, even a support that has been conventionally avoided due to its weak handling ability can be preferably used.

[Adhesive]
The adhesive is not particularly limited as long as it is a pressure-sensitive adhesive (co) polymer that can dissolve a drug and can be applied to the skin at room temperature for a long time as an adhesive such as a plaster or a tape. For example, an acrylic adhesive, a rubber adhesive, a silicon adhesive, and the like can be used. As the acrylic pressure-sensitive adhesive, for example, a (co) polymer mainly comprising a (meth) acrylic acid alkyl ester obtained from an aliphatic alcohol having 4 to 18 carbon atoms and (meth) acrylic acid is preferably used. Further, it may be a copolymer of (meth) acrylic acid alkyl ester and a functional monomer copolymerizable with the (meth) acrylic acid alkyl ester.

  Examples of rubber-based adhesives include natural rubber, synthetic isoprene rubber, polyisobutylene, polyurethane, polyisoprene, polybutadiene, styrene-butadiene copolymer, styrene-isoprene copolymer, and styrene-isoprene-styrene block copolymer. The main component is used.

  Furthermore, liquid rubber such as polybutene and polyisobutylene, hydrogenated petroleum resin, rosin, hydrogenated rosin, liquid paraffin, vegetable oil, lanolin and other softening agents can be blended. A percutaneous absorption enhancer such as a compound can also be blended.

  If necessary, additives such as stabilizers, fillers, and crosslinking agents can be added to the pressure-sensitive adhesive.

[How to use the patch]
The patch 1 of the present invention, when attached to the actual affected part, first and valley fold a line 311 and 321 formed outside the both sides of the cutting lines C1, C2, the center line l ₁ Make a mountain fold. As a result, the left convex part 312, the right convex part 322, the left convex part 313, and the right convex part 323 formed on the left and right peeling parts are lifted from the adhesive layer and the central peeling part 33 is also provided with the adhesive layer. It will be partly lifted off and easily peeled off.

  Next, the center peeling part 33 is peeled from the cutting lines C1 and C2, and the adhesive layer of the part is exposed. At this time, the left side protruding portion 312 and the left side protruding portion 313 are formed by the left side of the left side peeling portion 31, and the right side protruding portion 322 and the right side protruding portion 323 are formed by the left side of the right side peeling portion 32, In a state where both are engaged, the left convex portion 312, the right convex portion 322, the left convex portion 313, and the right convex portion 323 are alternately arranged in the short side direction in this order, and a hook-shaped central peeling is provided between the convex portions. A portion 33 is formed. Since these convex portions interfere with each other, even when the patch 1 is expanded or contracted in the left-right width direction (long side direction) after the central peeling portion 33 is peeled off, the exposed adhesive layers stick to each other. Can be effectively prevented.

  In this state, the left peeling part 31 and the right peeling part 32 are held with both hands, the adhesive surface of the patch is stuck to the affected part, and the left peeling part 31 and the right peeling part 32 are peeled. At this time, the left and right convex portions act as a knob, and if the left and right peeled portions are peeled off to the fold lines 311 and 321 by holding the knob in advance and then applied to the affected area, the patch further generates wrinkles and the like. And can be applied smoothly to the skin.

DESCRIPTION OF SYMBOLS 1 Patch 2 Support body 3 Release liner 31 Left side peeling part 32 Right side peeling part 33 Central peeling part 312, 313 Left side convex part 322, 323 Right side convex part 312a, 313a, 322a, 323a Tip part

Claims (7)

A support;
A release liner laminated via an adhesive layer on the support,
The release liner is divided into a central release portion, a left release portion, and a right release portion in the width direction by two cut lines formed in a crossing direction that intersects the width direction. ,
Depending on the shape of the cutting line, left side convex portions and right side convex portions are alternately formed along the intersecting direction on the side sides of the left side peeling portion and the right side peeling portion on the side of the central peeling portion, respectively. And
A patch in which, in the width direction, a part of the protruding end portion of the left convex portion is formed on the right side of a portion of the protruding end portion of the right convex portion adjacent to the crossing direction.   The patch according to claim 1, wherein a plurality of convex portions are formed on each of the left peeling portion and the right peeling portion.   The patch according to claim 1 or 2, wherein each of the convex portions is an arc. The support has a rectangular shape having a long side and a short side,
The patch according to any one of claims 1 to 3, wherein the central peeling portion has a ridge shape that advances while meandering left and right between the long sides of the support.   The patch according to claim 4, wherein the wrinkle width of the wrinkle shape is 3 mm or more, and the wrinkle distance is 105% or more and 300% or less of the linear distance of the short side.   The center peeling portion is formed so as to straddle a center line in a short side direction that equally divides the long side direction into two, and both the left convex portion and the right convex portion straddle the center line. 4. The patch according to 4 or 5.   A bending auxiliary line for standing a part of the right side peeling part and the left side peeling part near a central peeling part is formed in the right side peeling part and the left side peeling part. The patch according to the description.

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