JP2014039883A - Imaging device and imaging method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a solution for acquiring a correct tomographic image of a diseased region across plural planes, a very important technique for diagnosing a disease and grasping a disease state on a fundus tomographic imaging apparatus, whereas the conventional techniques have been unable to obtain tomography while a tomographic image of the disease region is being confirmed in multi-faceted manner during imaging of an examinee.SOLUTION: A fundus imaging low-coherent optical tomographic imaging device includes: means for acquiring time-division tomography on plural planes that mutually cross; means for displaying acquired images of the plural planes in respectively different regions on the same screen; and means for displaying a position of an individual display tomographic image, the position where another tomographic image crosses, for acquiring a tomographic image in a correct position.

Description

  The present invention relates to an imaging apparatus and an imaging method used for ophthalmic medical care and the like.

  Currently, various optical devices are used as ophthalmic devices. Among these, as an optical device for observing the eye, an imaging device using an anterior ophthalmoscope, a fundus camera, a confocal laser scanning ophthalmoscope (SLO), an optical coherence tomography (OCT) (hereinafter referred to as an optical coherence tomography: OCT). Various devices such as OCT apparatus are used. Among them, the OCT apparatus is an apparatus that obtains a tomographic image of the fundus with high resolution.

  An OCT apparatus is an apparatus that irradiates a sample represented by a retina with low coherent light and measures reflected light from the sample with high sensitivity by using an interferometer. In addition, the OCT apparatus can obtain a tomographic image by scanning the low-coherent light on the sample and causing the reflected return light to interfere with the reference light of the same light source that has passed through the reference light path. In particular, tomographic images of the retina are widely used for ophthalmic diagnosis.

  Since the OCT apparatus is an apparatus that acquires a tomogram, a single interferometer configuration can only acquire an image of a certain cross section at a certain timing. Therefore, it is difficult to obtain a tomographic image at a cross section that accurately passes through a diseased site. In order to solve this, Patent Document 1 shows an example in which an OCT tomographic image (B-scan image) and a confocal laser scanning ophthalmoscopic image (SLO image) are displayed on the same screen and an appropriate B-scan tomographic position is indicated. Has been. However, not all cases where an image showing a disease is displayed on an SLO image and the need to acquire a tomographic image of a diseased part in a plurality of cross sections of OCT have not been met.

JP2008-029467

  As described in the background art above, when a diseased eye is imaged using an OCT apparatus, it is necessary to accurately acquire a tomographic lesion. In addition to obtaining a tomographic image on a plane parallel to the eye axis, which is called a so-called B-scan image, it is desired to obtain a plane perpendicular to the eye axis, a so-called C-scan image. It is a problem to be solved by the present invention to accurately acquire a diseased site with a plurality of different cross sections as described above.

An imaging apparatus for acquiring a tomographic image of an eye to be inspected using the optical coherence tomography of the present invention includes means for independently instructing a change in each position of a plurality of surfaces intersecting each other, and the eye to be inspected corresponding to each position Means for acquiring a tomographic image of the area in a time-division manner, means for displaying the tomographic image, and crossing positions of the plurality of intersecting surfaces on each displayed tomographic image or in the vicinity of the tomographic image And means for displaying.
Further, the imaging apparatus of the present invention includes means for acquiring tomographic images on a plurality of intersecting surfaces in a time division manner, means for displaying the tomographic images on the plurality of surfaces, and intersecting of the plurality of intersecting surfaces. Means for displaying the position on each displayed tomographic image or in the vicinity of the tomographic image, and means for acquiring the tomographic images on the plurality of intersecting surfaces in a time-sharing manner, The Fourier domain method is switched by time division.
The imaging apparatus of the present invention controls the display means to display the first tomographic image of the eye to be examined in the first region of the display screen, and the first of the planes intersecting the plane of the first tomographic image. Image display control means for displaying the two tomographic images in the second area of the display screen, and the display means is controlled so that the plane of the first tomographic image and the plane of the second tomographic image intersect. Position display control means for displaying the information indicating the position to be displayed in each of the first and second areas, and independently changing the position indicated by the information displayed in the first and second areas Position change instructing means; and means for acquiring a new second tomographic image of the surface corresponding to the changed position using scanning means for scanning the eye to be examined with light, wherein the image display control means Controlling the display means so that the new second disconnection in the second region is performed. Characterized in that to display an image.
The imaging device of the present invention is an imaging device that takes an image of the subject eye based on return light from the subject eye that has been irradiated with light, and includes a plurality of surfaces that intersect with each other based on the image of the subject eye. Instructing means for independently instructing a change of position, and means for acquiring an image of the region of the eye to be examined corresponding to the changed position using a scanning means for scanning the eye with the light. To do.
Furthermore, an imaging method for acquiring a tomographic image of an eye to be examined using the optical coherence tomography method of the present invention includes a step of independently instructing a change in each position of a plurality of surfaces intersecting each other, and the above-described corresponding to each position A step of acquiring a tomographic image of the region of the eye to be examined in a time-division manner, a step of displaying the tomographic image on an image display device, and displaying intersection positions of the plurality of mutually intersecting surfaces on or near each display image. And a process.
Furthermore, the imaging method of the present invention includes a step of acquiring tomographic images on a plurality of mutually intersecting surfaces in a time division manner, a step of displaying the tomographic images on the plurality of surfaces, and an intersection of the plurality of intersecting surfaces. A step of displaying the position on each displayed tomographic image or in the vicinity of the tomographic image, and in the step of acquiring the tomographic images on the plurality of intersecting surfaces in a time-sharing manner, The Fourier domain method is switched by time division.
Furthermore, in the imaging method for taking an image of the eye to be inspected based on the return light from the eye to be inspected according to the present invention, the position of a plurality of intersecting surfaces can be changed independently based on the image of the eye to be inspected. A step of instructing, and a step of acquiring an image of the region of the eye to be examined corresponding to the change position using a scanning unit that scans the eye to be examined with light.
Furthermore, in the imaging method of the present invention, the first tomographic image of the eye to be examined is displayed in the first region of the display screen, and the second tomographic image of the plane intersecting the first tomographic image is displayed. The step of displaying in the second area of the screen, and information indicating the position where the plane of the first tomographic image and the plane of the second tomographic image intersect each other in each of the first and second areas A step of displaying, a step of independently instructing a change of the position indicated by the information displayed in the first and second areas, and a scanning position that scans the eye to be inspected with light. And a step of acquiring a new second tomographic image of the surface to be displayed and a step of displaying the new second tomographic image in the second region.

  According to the present invention, by displaying the in-plane tomographic position, it is possible to correctly indicate the relationship between the crossing positions of the respective faults.

It is a screen display of 1st Embodiment of this invention. It is the apparatus schematic diagram (a) and control block diagram (b) of 1st Embodiment of this invention. It is a control waveform diagram of the first embodiment of the present invention. It is a screen display of 2nd Embodiment of this invention. It is the apparatus schematic diagram (a) and control block diagram (b) of 2nd Embodiment of this invention. It is a control waveform diagram of the second embodiment of the present invention.

  The best mode for carrying out the present invention will be described with reference to the drawings.

<Display unit of imaging apparatus using optical coherence tomography>
A display unit of an imaging apparatus using an optical coherence tomography for imaging the fundus according to the present embodiment will be described with reference to FIG. Two cross-sections can be displayed on the display screen 101 of the photographing apparatus. Here, a so-called B scan image 102 that is a tomographic image in a cross section parallel to the eye axis and a so-called C scan image 105 that is a tomographic image in a cross section orthogonal to the eye axis are displayed. In this way, two acquired tomographic images (first and second tomographic images) can be displayed as images in two regions (first and second regions) on the same screen. For example, the position where the C scan image 102 intersects the B scan image 102 is 103. Similarly, the intersection position of the B scan image 102 with respect to the C scan image 105 is 106. In order to perform a change instruction operation for changing the intersection position 103 on the display image, in other words, a position change control 104 (position change instruction means) for performing a change instruction operation for changing the tomographic acquisition position of the C scan image 105 is prepared. Has been. In order to change the intersection position 106 on the display image, in other words, a position change control 107 (position change instruction means) for changing the tomographic acquisition position of the B-scan image 102 is prepared.
Here, the display screen 101 is shown in the form of a so-called GUI (graphical user interface), but is not limited thereto. Further, the position display means for indicating the display positions 103 and 106 also displays a line on the image in the drawing, but an arrow or the like may be displayed on the side of the image. In order to sufficiently show the image information to the examiner, a blinking display may be used. Further, the position change controls 104 and 107 may be in the form of a slider based on a GUI as shown in this drawing. For example, an operation with a mouse wheel is performed on an image selection without being clearly shown. You can also use the keyboard cursor. Furthermore, although the display image in the two cross sections is shown in the drawing, it is needless to say that the display may display three or more cross sections.

<Imaging device using optical coherence tomography>
An imaging apparatus using optical coherence tomography for imaging the fundus according to the present embodiment will be described with reference to FIG. As the low-coherent light source 201, an SLD light source (Super Luminescent Diode) or an ASE light source (Amplified Spontaneous Emission) can be suitably used.

The wavelength used is preferably a wavelength band near 850 nm or a wavelength band near 1050 nm, which is suitable for fundus diagnosis.
An SS light source (Swept Source) can also be used. In that case, however, it is necessary to use an SS-OCT light source in a different manner from the configuration of this drawing. Light is guided to the fiber collimator 203 by the optical fiber 202 and serves to guide the light to the interferometer as parallel light. The beam is split into reference light and sample light by the beam splitter 204. An optical path 205 of sample light includes dispersion compensation glasses 206 and 207 corresponding to AOM described later, a beam splitter 208, a galvano scanner 209 for scanning the X axis (horizontal direction), lenses 210 and 211, and a Y axis (vertical direction) scanning. The galvano scanner 212 passes through. Further, the fundus of the eye 215 to be examined is scanned as indicated by an arrow 216 via the lenses 213 and 214. Here, since the lens 214 also serves as a focusing lens, the lens 214 can be moved as indicated by an arrow in the drawing, and the focal position of the imaging system can be changed in accordance with the refractive state (myopia or hyperopia) of the eye 215 to be examined. Can do. The focal position of the imaging system can be changed at the time of an instruction to change the intersection position of the scanned images. The optical path 217 of the reference light passes through AOMs (photoacoustic modulators) 218 and 219. The AOMs 218 and 219 perform modulation at different frequencies, and as a result, are used in a state where they are modulated with a difference in frequency. The optical path length of the optical path 217 of the reference light is variable by mirrors 221 and 222 on the stage 220 for changing the optical path length of the reference light. Here, as the stage 220, a linear motor stage, a boil coil motor stage, or an ultrasonic motor stage can be used. Further, the optical path 217 of the reference light passes through the mirror 223 and the dispersion compensation glass 224 and reaches the beam splitter 225 for multiplexing the sample light and the reference light. The dispersion compensation glass 224 is for taking the influence of the lens in the optical path of the sample light and the water in the eyeball.
Each light acquired by the fiber collimators 226 and 227 is a fiber and is guided to a processing unit 228 including a balanced detector, which will be described later, and interference signals are detected, imaged, and displayed.

  The configuration of the interferometer has been described above. With this configuration, a time domain type OCT apparatus capable of a transverse scan (in-plane scan) is provided. That is, the apparatus configuration is such that acquisition of a B scan image and acquisition of a C scan image can be performed in a time division manner. The transverse scan type OCT described in the present invention refers to a time domain type OCT in which the main scanning direction is a direction perpendicular to the eye axis. However, the low-coherent optical tomographic imaging apparatus constituting the present invention is not necessarily required to be a time domain type OCT capable of a transverse scan because it is only necessary to obtain cross-sectional tomographic cross sections that are different in time division. In other words, Fourier domain OCT, spectral domain OCT (SD-OCT), wavelength scanning type (Swept Source) OCT (SS-OCT), as well as time domain format OCT, transverse scan OCT (TS-OCT) Either can be used. Furthermore, OCT which can be switched in a time division manner may be used. Of course, a Mach-Zehnder interferometer configuration as shown in this drawing or a Michelson interferometer configuration may be used.

(Example 1) The imaging device using the optical coherence tomography according to Example 1 is as follows.

<Display screen>
First, the display unit of the imaging apparatus will be described with reference to FIG. On the display screen 101 of the imaging apparatus, two cross-sectional tomographic images (first and second tomographic images) can be displayed in two regions (first and second regions). A so-called B scan image 102 which is a tomographic image in a cross section parallel to the eye axis and a so-called C scan image 105 which is a tomographic image in a cross section perpendicular to the eye axis are displayed. The intersection position 103 of the C scan image 105 with respect to the B scan image 102 is indicated by a line as a position display means. Similarly, the intersection position 106 of the B scan image 102 with respect to the C scan image 105 is indicated by a line. In order to change the intersection position 103, in other words, the position change control 104 (position change instruction means) for changing the tomographic position of the C scan image 105. Reference numeral 107 denotes a position change control 107 (position change instruction means) for changing the tomographic position of the B-scan image 102 in order to change the intersection position 106.

<Device configuration>
Next, the imaging apparatus for imaging the fundus according to the present embodiment will be described with reference to FIG. The low coherent light source 201 uses an SLD light source (Super Luminescent Diode) having a central wavelength of 840 nm. The light emitted from the light source is guided by the single mode optical fiber 202 and the fiber collimator 203, and is guided to the interferometer as parallel light. Then, the beam is split into reference light and sample light by the beam splitter 204. The optical path 205 of the sample light reaches the beam splitter 208 through dispersion compensating glasses 206 and 207 corresponding to AOM described later. The fundus of the eye 215 to be scanned is scanned as indicated by an arrow 216 via the galvano scanner 209 for scanning the X axis (horizontal direction), the lenses 210 and 211, the galvano scanner 212 for scanning the Y axis (vertical direction), and the lenses 213 and 214. Let Here, since the lens 214 also serves as a focusing lens, it can be moved by a stage (not shown) as indicated by an arrow in the drawing. The focal position of the imaging system can be changed in accordance with the refractive state (myopia or hyperopia) of the eye 215 to be examined. The optical path 217 of the reference light passes through AOMs (photoacoustic modulators) 218 and 219. The AOMs 218 and 219 modulate the reference light at 40 MHz and 41 MHz, respectively, and as a result, use the reference light that is modulated at 1 MHz. Mirrors 221 and 222 are mounted on a stage 220 for making the optical path length of the reference light variable. Here, a linear motor is used as the stage 220. Further, the reference light passes through the mirror 223, the lens in the optical path of the sample light, and the dispersion compensation glass 224 for taking the influence of water in the eyeball, and reaches the beam splitter 225 for combining the sample light and the reference light. . Each light acquired by the fiber collimators 226 and 227 is a fiber and is guided to a processing unit 228 including a balanced detector, which will be described later, and interference signals are detected, imaged, and displayed.

<Control block diagram and control waveform>
Next, a block diagram illustrating the processing unit 228 of this embodiment will be described with reference to FIG. A central processing unit 301 that controls the entire control, a display screen 302 that displays a tomographic image, a fixed disk device 303 that stores a control program and a result, a control program that is read, and a process that processes acquired data To drive a main memory area 304, a keyboard / mouse operation interface 305 for performing an operation by an examiner, a DA converter 306 for generating a waveform for controlling an actuator to be described later, and an X-axis scanner. Scanner driver 307, scanner driver 308 for driving the Y-axis scanner, stage controller 309 for driving the stage for changing the optical path length of the reference light, and lens driving stage for driving the focusing lens The controller 310 is configured. The drivers 307 and 308 and the controllers 309 and 310 are analog servo mechanisms that follow the control waveform generated by the DA converter 306. The waveforms for controlling these will be described later. A balanced detector 313 for receiving an interference signal and converting the voltage is extracted by a band pass filter 312 only at a frequency in the vicinity of 1 MHz, here, a band of 500 kHz to 1.5 MHz, and converted to a digital value by an AD converter 311. , Image. The capture of one image is synchronized with the capture of the frame capture trigger waveform signal 314. The frame capture trigger waveform signal 214 is generated by the DA converter 306 and is generated in synchronization with the control waveform of each actuator. The AD converter 311 operates based on the rising signal of the frame capture trigger, and acquires data having a data length of one frame. When the amplitude of this data is obtained and imaged, a tomographic image can be generated.

  Next, the description of the control waveform signal and the actual control operation will be described with reference to FIGS. A control waveform signal 401 of the X-axis galvano scanner 209 is a signal for scanning with a sine wave of 500 Hz. The control waveform signal 402 of the Y-axis galvano scanner 212, the stage control waveform signal 403 for adjusting the optical path length of the reference light, and the control waveform signal 404 of the stage for focusing are signals for driving the corresponding actuators. is there. These signals are generated periodically.

  Each control waveform signal 402, 403, 404 is driven as described below. Reference numeral 405 denotes a frame capture trigger waveform signal. The signal recording starts at each rising edge, and the signal recording ends at the falling edge. Reference numerals 406, 407, and 408 denote data acquisition times for one frame (tomographic section), respectively. At time 406, the Y-axis is scanned at a constant speed while the Z-axis is fixed, and a C-scan image can be acquired. At this time, the Z axis, which is the optical path length of the reference light, is fixed at a position corresponding to the position 103 shown in FIG. Similarly, Focus also fixes the focus at a focus position corresponding to the Z position 103 (a position where the Z position of the fundus is in focus). The image acquired at time 406 is displayed in the area 105 in FIG. 1 (the display is updated). At time 407, since the Z-axis is scanned while the Y-axis 402 is fixed, a B-scan image can be acquired. At this time, the Focus 404 is fixed at an intermediate position in the Z direction.

However, the focus position here may be scanned according to the Z position. Here, the image acquired at time 407 is displayed in the area 102 in FIG. 1 (the display is updated). Here, it is assumed that the control 104 in FIG. 1 is operated. At this time, it is necessary to change the tomographic position of the C-scan image after the intersection position change instruction operation. At the time of waveform generation at time 408, the Z-axis waveform 403 and the Focus-axis waveform 404 are changed to corresponding positions. Further, in synchronization with the waveform generation at time 408, the illustrated pattern at the intersection position 103 in FIG. 1 is moved to the corresponding depth. Similarly, when the control 107 is operated, the fixed position of the Y axis at the next B scan acquisition timing corresponding to time 407 is changed. In this way, the tomographic image at the changed position is acquired based on the position change instruction, and the position information indicating the position where the tomographic image intersects is changed.
By having the above control function, the examiner can record a two-section cross-section at an appropriate position during imaging of the subject.

(Example 2)
An imaging apparatus using the optical coherence tomography according to the second embodiment is as follows.

<Display screen>
A display unit of the imaging apparatus using the optical coherence tomography according to the second embodiment will be described with reference to FIG. On the display screen 501 of the imaging apparatus, it is possible to display three cross-sectional tomographic images (first, second, and third tomographic images) in three regions (first, second, and third regions). . On this screen, so-called B scan images 502 and 506, which are cross-sectional tomographic images parallel to the eye axis, and a C scan image 511 orthogonal to the eye axis are displayed. The B scan images 502 and 506 have their intersection positions displayed at corresponding positions 514 and 512 on the C scan image 511. That is, the B scan image 502 has a cross section in the X axis direction (a cross section in the horizontal plane when the subject is standing upright), and the other B scan image 506 has a cross section in the Y axis direction ( When the subject is standing upright, the cross section is vertical). An intersection position 503 indicates a cross-section intersection part of the B-scan image 506. A control 504 is a control (position change instruction unit) for changing the tomographic position of the B-scan image 506. An intersection position 505 indicates an intersection position with the cross section of the C scan image 511. An intersection position 507 indicates an intersection position with the cross section of the B scan image 502, and an intersection position 509 indicates an intersection position with the cross section of the C scan image 511 similarly to the intersection position 505. A control 508 is a control for changing the cross-sectional position of the intersection position 502, and a control 510 is a control for changing the cross-sectional position of the C-scan image 511. The intersection position 512 indicates the position of the B scan image 506, and the intersection position 514 indicates the position of the B scan image 502. A control 513 is interlocked with the control 504 and is a control for changing the position of the B-scan image 506. A control 515 is a control for changing the position of the B-scan image 502. Note that all intersection positions are represented by lines as position display means.

<Device configuration>
The apparatus configuration of the imaging apparatus according to the present embodiment will be described with reference to FIG. The present embodiment shows a configuration example in which a transverse OCT (TS-OCT) and a spectral domain OCT (SD-OCT) are combined. The low coherent light source 601 uses an SLD light source (Super Luminescent Diode) having a central wavelength of 840 nm. The light emitted from here is guided to the fiber collimator 603 by the single mode optical fiber 602 and guided to the interferometer as parallel light. The beam is split into reference light and sample light by a beam splitter 604. The optical path 605 of the sample light passes through dispersion compensation glasses 606 and 607 corresponding to AOM described later and reaches the beam splitter 608. Further, it passes through the galvano scanner 609 for X-axis (horizontal direction) scanning, lenses 610 and 611, and the galvano scanner 612 for Y-axis (vertical direction) scanning, and the fundus of the eye 615 to be examined is indicated by an arrow 616 via the lenses 613 and 614. Scan as shown. Here, since the lens 614 also serves as a focusing lens, the lens 614 can be moved by a stage (not shown) as indicated by an arrow in the drawing. The focal position of the imaging system can be changed in accordance with the refractive state (myopia or hyperopia) of the eye 615 to be examined. Reference numeral 617 denotes an optical path changer. When the state of the optical path changer 617 is the state indicated by 618, light is guided to the optical path 618 of the TS-OCT, and when the state of the optical path changer 617 is the state 619, the optical path is guided to the SD-OCT. It has become. For this purpose, the mirror is rotated, and a solenoid actuator is used for driving. The optical path of the sample light at the time of TS-OCT is 620, and the light is guided to the beam splitter 621 for multiplexing with the reference light at the time of TS-OCT. A TS-OCT signal is acquired by a balanced detector included in a processing unit 624 described later on the light collected by the fiber collimators 622 and 623. The light is guided to the mirror 626 in the optical path 625 of the sample light in SD-OCT, and the sample light is guided to the fiber by the fiber collimator 627.

  The reference light path 628 guides light to the mirror 629. Furthermore, it passes through the dispersion compensation glass 630 corresponding to the lens of the sample optical path and the water (vitreous body, crystalline lens, aqueous humor) of the eye to be examined, and reaches the stage 631 for changing the optical path length of the reference light. Here, a linear motor stage is used. The reference light is folded back by mirrors 632 and 633 mounted on the stage and guided to AOMs (photoacoustic modulators) 634 and 635. Here, in TS-OCT, the reference light is modulated at 40 MHz and 41 MHz, respectively, and as a result, it is used in a state of being modulated at 1 MHz. At the time of SD-OCT, both are used in a state where the reference light is not modulated in a state of 40 MHz. The optical path changer 636 becomes the optical path of TS-OCT in the state 637, and becomes SD-OCT in the state 638. This mechanism, like the optical path changer 617, rotates the mirror using a solenoid. The reference light is guided to the beam splitter 621 when it becomes the optical path 639 of the reference light at the time of TS-OCT. When it becomes the optical path 640 of the reference light at the time of SD-OCT, it is guided to the fiber collimator 641. The sample light and the reference light at the SD-OCT guided by the fiber collimators 627 and 641 are combined by the fiber coupler 642. Thereafter, the light is emitted from the fiber collimator 643, dispersed by the spectroscope 644, received by the line sensor camera 645, and transmitted to the processing unit 624.

<Control block diagram and control waveform>
A block diagram of the processing unit 624 of the imaging apparatus according to the present embodiment will be described with reference to FIG. A central processing unit 701 that controls the entire control, a display screen 702 that displays a tomographic image, a fixed disk device 703 that stores control programs and stores results, a control program that reads, and processes acquired data To drive a main storage area 704, a keyboard / mouse operation interface 705 for performing an operation by an examiner, a DA converter 706 for generating a waveform for controlling an actuator to be described later, and an X-axis scanner 609. Scanner driver 707, scanner driver 708 for driving the Y-axis scanner 612, stage controller 709 for driving the stage 631 for changing the optical path length of the reference light, and lens driving for driving the focusing lens 614 The stage controller 710 for . The drivers 707 and 708 and the controllers 709 and 710 have an analog servo mechanism that follows the control waveform generated by the DA converter 706. The waveforms for controlling these will be described later. Further, the photoacoustic modulators 712 and 713 are controlled by the controller 711 of the photoacoustic modulator. Here, the photoacoustic modulator 712 is always switched to 40 MHz during TS-OCT and SD-OCT, and the photoacoustic modulator 713 is switched to 41 MHz during TS-OCT and 40 MHz during SD-OCT. Switching is performed based on the OCT switching signal 716. The optical path changers 714 and 715 correspond to the optical path changers 617 and 636 in FIG. 5A, and switch the optical path by the OCT switching signal 716.

  A signal obtained by a balanced detector 719 for receiving an interference signal and converting the voltage is extracted by a band pass filter 718 only at a frequency near 1 MHz, here, a band of 500 kHz to 1.5 MHz, and digitally converted by an AD converter 717. Convert to value and image. The capture of one image is synchronized with the capture of a TS-OCT capture trigger signal 720. This frame capture trigger waveform signal is generated by the DA converter 706 and is generated in synchronization with the control waveform signal of each actuator. The AD converter 717 operates based on the rising edge of the frame capture signal and acquires data having a data length of one frame. When the amplitude of this data is obtained and imaged, a tomographic image can be generated. Capturing is performed based on the rise of the SD-OCT capturing signal 722 and the line sensor camera 721 of the spectrometer for SD-OCT. In this line sensor camera, a tomographic image can be obtained by Fourier-transforming a plurality of captured spectrum signals. Next, explanation of control waveforms and actual control operation will be described with reference to FIGS. FIG. 6 shows an X-axis galvano scanner control waveform signal 801, a Y-axis galvano scanner control waveform signal 802, a reference light path length adjustment stage control waveform signal 803, and a focus stage control waveform signal. 804 is shown.

The control waveforms 801 to 804 are driven as described later. The OCT switching signal 805 switches the interferometer to the SD-OCT state when it is at a high level. More specifically, the frequency of the photoacoustic modulator 713 is changed by the optical path changer 617 of FIG. 5A to the mirror position 619, the optical path changer 636 to the mirror position 638, and the controller 711 of FIG. Switch to 40 MHz respectively. Needless to say, when this signal is at a low level, the interferometer is switched to the TS-OCT state. More specifically, the frequency of the photoacoustic modulator 713 is changed by the optical path changer 617 of FIG. 5A to the mirror position 618, the optical path changer 636 to the mirror position 637, and the controller 711 of FIG. Are respectively switched to 41 MHz. Although not related to the essence of the present invention, when the photoacoustic modulator 713 is switched, the angle of the optical path slightly changes. This change is adjusted by the switching mirror position 636. An SD-OCT frame trigger waveform signal 806 and a TS-OCT frame trigger waveform signal 807 trigger an image capture. The SD-OCT acquisition times 808 and 809 are shown as the B-scan tomographic image acquisition time 808 in the X-axis direction. A B-scan tomogram is acquired by scanning the X-axis with the signal 801. It is an acquisition time 809 for a B-scan tomographic image in the Y-axis direction. A B-scan tomogram is acquired by scanning the Y-axis with the signal 802. During scanning at times 808 and 809, the Z-axis is driven to a position moved to the near side (position corresponding to the vitreous body side) with respect to the fundus by the signal 803. That is, it is driven to a position where no mirror image is present when obtaining SD-OCT. The tomographic image acquired at the acquisition time 808 is displayed in the area 502 of FIG. The tomographic image acquired at the acquisition time 809 is displayed in the area 506 in FIG. Each is updated to the latest image every time it is acquired. At the TS-OCT acquisition time 810, the X-axis of the signal 801 is a signal for scanning with a sine wave of 500 Hz, and the Y-axis of the signal 802 is a signal for scanning at a constant speed, the signal 803. The Z axis is a signal fixed at a fixed position. The Z-axis fixed position of the signal 803 is a position corresponding to the positions 505 and 509 in FIG. Therefore, a C-scan tomographic image is acquired by TS-OCT at time 810. Although it is the same as in the first embodiment, needless to say, it is desirable to drive the focus 804 to a position corresponding to the Z-axis position of the signal 803. Further, when the controls 504, 508, 510, 513, and 515 in FIG. 4 are operated, when the next waveform is generated, the control 504 is the position of the signal 801 (X) at the time 809, and the control 508 is the signal 802 (Y). The position of time 808, control 510 changes the position of signal 803 (Z) at time 810, control 513 changes the position of signal 801 (X) at time 809, and control 515 changes the position of signal 802 (Y) at time 808. The cross sectional position of the screen is changed in the same manner. The relationship between the control and the cross-section position is as follows: control 504 is position 503 and position 512, control 508 is position 507 and position 514, control 510 is position 505 and position 509, control 513 is position 503 and position 512, and control 515 is position 507. And the position 514 correspond to each other, and the corresponding display position is changed. In this way, the tomographic image at the changed position is acquired based on each position change instruction, and the position information indicating the position where the tomographic image intersects is changed.
By having the above control function, the examiner can accurately record the three-section cross-section at an appropriate position during the photographing of the subject. In the present embodiment, an example in which TS-OCT and SD-OCT are combined is shown, but it goes without saying that similar image recording may be performed by using SD-OCT alone.
As described above, according to each embodiment, it is possible to indicate to the examiner who has acquired a fundus tomographic image whether or not a plurality of acquired cross sections are correctly tomographic lesions. Further, by displaying the in-plane tomographic position, it is possible to correctly indicate the relationship between the crossing positions of the respective faults. In addition, when the tomographic position changing function is provided, the tomographic position can be changed to the correct tomographic position by a simple operation when the imaging position is shifted with respect to the diseased part.
(Other examples)
The present invention can also be realized by executing the following processing. That is, software (program) that realizes the functions of the above-described embodiments is supplied to a system or apparatus via a network or various storage media, and a computer (or CPU, MPU, or the like) of the system or apparatus reads the program. It is a process to be executed.

101 Display screen
102 First section display section
103 Second section position display
104 Second section position change control
105 Second section display section
106 First section position display
107 First section position change control

As described in the background art above, when a diseased eye is imaged using an OCT apparatus, it is necessary to accurately acquire a tomographic lesion . It is an object to solve the present invention accurately obtains the illness site at different multiple section.

Claims (27)

An imaging device that acquires a tomographic image of an eye to be examined using optical coherence tomography,
Means for independently instructing a change of each position of a plurality of surfaces intersecting each other;
Means for acquiring, in a time division manner, a tomographic image of the region of the eye to be examined corresponding to each position;
Means for displaying the tomographic image;
Means for displaying intersection positions of the plurality of intersecting surfaces on each displayed tomographic image or in the vicinity of the tomographic image;
An imaging device comprising:   Means for acquiring, in a time division manner, a tomographic image of the region of the eye to be examined corresponding to each position, sequentially acquiring each of the tomographic images of the region of the eye to be examined corresponding to each position at a predetermined acquisition time; The imaging apparatus according to claim 1, wherein the imaging apparatus is characterized. On the displayed tomographic image of any one of the tomographic images of the region of the eye to be examined corresponding to each position, means capable of performing an instruction to change the intersection position;
Means for changing the displayed tomographic image to a tomographic image corresponding to an intersection position based on the change instruction operation;
The imaging apparatus according to claim 1, wherein the imaging apparatus includes:   The imaging apparatus according to claim 3, further comprising means for changing a focal position of an imaging system when the intersection position change instruction operation is performed.   The means for acquiring the tomographic image of the region of the eye to be examined corresponding to each position in a time division manner switches between a transverse scan method and a Fourier domain method in a time division manner. The imaging device according to any one of the above. Means for acquiring tomographic images in a plurality of planes intersecting each other in a time-sharing manner;
Means for displaying a tomographic image on the plurality of surfaces;
Means for displaying intersection positions of the plurality of intersecting surfaces on each displayed tomographic image or in the vicinity of the tomographic image;
Have
An imaging apparatus, wherein the means for acquiring tomographic images on a plurality of mutually intersecting surfaces in a time division manner switches between a transverse scan method and a Fourier domain method in a time division manner. By controlling the display means, the first tomographic image of the eye to be examined is displayed in the first region of the display screen, and the second tomographic image of the surface intersecting the surface of the first tomographic image is displayed on the display screen. Image display control means for displaying in the second area;
Position display for controlling the display means to display information indicating the position where the plane of the first tomographic image and the plane of the second tomographic image intersect in each of the first and second regions. Control means;
Position change instruction means for independently instructing a change in position indicated by the information displayed in the first and second areas;
Means for acquiring a new second tomographic image of the surface corresponding to the change position using scanning means for scanning the eye to be examined with light,
The imaging apparatus, wherein the image display control means controls the display means to display the new second tomographic image in the second region. The image display control unit controls the display unit to display a third tomographic image of a plane that intersects the plane of the first tomographic image and the plane of the second tomographic image, on the display screen. In the area of 3,
The position display control means controls the display means to obtain information indicating a position where the plane of the first tomographic image and the plane of the third tomographic image intersect with each other. Displayed in each of the three areas,
The position change instruction means performs a change instruction to change the position indicated by the information displayed in the third area;
8. The imaging according to claim 7, wherein the image display control unit controls the display unit to display a new first tomographic image of a surface corresponding to the changed position in the first region. apparatus.   The surface of the first tomographic image displayed in the third region is changed while changing the information indicating the position where the surface of the new second tomographic image and the surface of the first tomographic image intersect. The imaging apparatus according to claim 8, further comprising position information changing means for changing information indicating information on a position intersecting with the position information. An imaging device for taking an image of the subject eye based on return light from the subject eye irradiated with light,
Instruction means for independently instructing to change the positions of a plurality of surfaces intersecting each other based on the image of the eye to be examined;
Means for acquiring an image of the region of the eye to be examined corresponding to a change position using a scanning means for scanning the eye to be examined with light;
An imaging device comprising:   11. The imaging apparatus according to claim 10, further comprising display control means for controlling the display means to display images acquired continuously within a predetermined time.   12. The image according to claim 10 or 11, wherein the image is an optical coherence tomographic image of the eye to be examined in an axial direction and an optical coherent tomographic image of the eye to be examined in a direction substantially perpendicular to the direction of the axial axis. Imaging device. Means for moving the focal position based on an instruction from the instruction means;
Means for moving the position of the coherence gate based on an instruction of the instruction means;
The imaging apparatus according to claim 10, wherein the imaging apparatus includes: An imaging method for obtaining a tomographic image of an eye to be examined using optical coherence tomography,
Independently instructing the change of each position of a plurality of surfaces intersecting each other;
Obtaining a tomographic image of the region of the eye to be examined corresponding to each position in a time-sharing manner;
Displaying the tomographic image on an image display device;
Displaying the crossing positions of the plurality of intersecting surfaces on or near each display image;
An imaging method characterized by comprising:   In the step of acquiring the tomographic image of the region of the eye to be examined corresponding to each position in a time division manner, each of the tomographic images of the region of the eye to be examined corresponding to each position is sequentially acquired at a predetermined acquisition time. The imaging method according to claim 14, wherein the imaging method is characterized. On the displayed tomographic image of any one of the tomographic images of the region of the eye to be examined corresponding to each position, operating the change instruction of the intersecting position;
Changing the displayed tomographic image to a tomographic image corresponding to an intersection position based on the change instruction operation;
The imaging method according to claim 14 or 15, characterized by comprising:   The imaging method according to claim 16, further comprising a step of changing a focal position of the imaging system in the step of operating the change instruction of the intersection position.   The step of acquiring the tomographic image of the region of the eye to be examined corresponding to each position in a time division manner is switched between the transverse scan method and the Fourier domain method in a time division manner. The imaging method according to any one of the above. Acquiring tomographic images in a plurality of planes intersecting each other in a time-sharing manner;
Displaying the tomographic images on the plurality of surfaces;
Displaying the crossing positions of the plurality of intersecting surfaces on each displayed tomographic image or in the vicinity of the tomographic image;
Have
An imaging method characterized in that, in the step of acquiring tomographic images on a plurality of mutually intersecting surfaces in a time division manner, the transverse scan method and the Fourier domain method are switched in a time division manner. An imaging method for taking an image of the subject eye based on the return light from the subject eye irradiated with light,
Independently instructing to change the position of a plurality of surfaces intersecting each other based on the image of the eye to be examined;
Obtaining an image of the region of the subject eye corresponding to the change position using a scanning unit that scans the eye with light; and
An imaging method characterized by comprising:   21. The imaging method according to claim 20, further comprising a step of controlling the display means to display images acquired continuously within a predetermined time.   The said image is an optical coherence tomographic image in the direction of the eye axis of the eye to be examined and an optical coherent tomographic image in a direction substantially perpendicular to the direction of the eye axis of the eye to be examined. Imaging method. A step of moving a focal position based on an instruction of the instructing step;
Moving the position of the coherence gate based on the instruction of the instructing step;
The imaging method according to any one of claims 20 to 22, characterized by comprising: Displaying a first tomographic image of the eye to be examined in a first region of the display screen;
Displaying a second tomographic image of a plane intersecting the first tomographic image in a second region of the display screen;
Displaying information indicating the position where the plane of the first tomographic image and the plane of the second tomographic image intersect in each of the first and second regions;
Independently instructing a change in position indicated by the information displayed in the first and second areas;
Obtaining a new second tomographic image of the surface corresponding to the changed position using a scanning means for scanning the eye to be examined with light;
Displaying the new second tomographic image in the second region;
An imaging method characterized by comprising: Displaying a third tomographic image of a surface intersecting the surface of the first tomographic image and the surface of the second tomographic image in a third region of the display screen;
Displaying information indicating a position where the plane of the first tomographic image and the plane of the third tomographic image intersect in each of the first region and the third region;
Performing a change instruction to change the position indicated by the information displayed in the third area; and
Displaying a new first tomographic image of the surface corresponding to the changed position in the first region;
The imaging method according to claim 24, comprising:   The surface of the first tomographic image displayed in the third region is changed while changing the information indicating the position where the surface of the new second tomographic image and the surface of the first tomographic image intersect. 26. The imaging method according to claim 25, further comprising a step of changing information indicating information on a position intersecting with.   A program that causes a computer to execute each step of the imaging method according to any one of claims 14 to 26.