JP2014036687A

JP2014036687A - Injection syringe for kit preparation and kit preparation

Info

Publication number: JP2014036687A
Application number: JP2012178751A
Authority: JP
Inventors: Senkichi Okano; 仙吉岡野
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-08-10
Filing date: 2012-08-10
Publication date: 2014-02-27

Abstract

PROBLEM TO BE SOLVED: To provide a kit preparation of a type that enables a simplified, quick, and easy injection without errors, and an injection syringe for a kit preparation that can achieve the kit preparation.SOLUTION: An injection syringe for a kit preparation includes: a medicinal solution chamber for keeping a medicinal solution in the inside; injection needles having proximal portions that communicate with the medicinal solution chamber at one end of the medicinal solution chamber; a cylindrical spring storing chamber for storing a coil spring in the inside on the other end side of the medicinal solution chamber; and a spring compression releasing means which keeps the coil spring in a compressed state and releases the compression on the coil spring in the injection operation to supply the medicinal solution in the medicinal solution chamber to the injection needles by the coil spring.

Description

本発明は、インフルエンザや肝炎等のワクチン、あるいは、インスリンなどの、特に皮下注射に適したキット製剤用注射器、および、そのようなキット製剤用注射器を有するキット性材に関する。 The present invention relates to a syringe for a kit preparation particularly suitable for subcutaneous injection, such as a vaccine for influenza or hepatitis, or insulin, and a kit material having such a syringe for kit preparation.

インフルエンザや肝炎等のワクチン、あるいは、インスリンなどの注射は皮下注射であることが多く、また、液量も０．２５〜１ｍＬ程度のごく少量であることが多い。 Injection of vaccines such as influenza and hepatitis, or insulin is often subcutaneous injection, and the amount of liquid is often very small such as about 0.25 to 1 mL.

しかしながら、液量が極端に少ないＢＣＧ接種に用いられる注射器とは違い、一般的な注射器形状のキット製剤が用いられており（特許文献１等）、多人数に短時間で接種することは困難で、簡易にかつ迅速に注射できるキット製剤が求められていた。 However, unlike syringes used for BCG inoculation with extremely small liquid volume, general syringe-shaped kit preparations are used (Patent Document 1, etc.), and it is difficult to inoculate many people in a short time. Therefore, there has been a demand for a kit preparation that can be easily and rapidly injected.

また、インスリンは患者が自分で注射することが多く、このために誤りなく、かつ、手軽に注射できるタイプのキット製剤が求められていた。 Insulin is often injected by the patient himself, and for this reason, there has been a demand for a kit preparation of a type that can be injected easily without error.

さらに、疼痛の少ない、極細の注射針を用いたときに、圧力損失が大きいために注射終了までに長い時間がかかり、被投与者のみならず投与者の負担が大きく、改良が求められていた。 Furthermore, when using an ultra-fine injection needle with little pain, it took a long time to complete the injection due to the large pressure loss, and the burden on not only the recipient but also the recipient was great, and improvements were required. .

特開２０１２−４５２０３号公報JP 2012-45203 A

本発明は、上記した従来の問題点を改善する、すなわち、簡易にかつ迅速に、誤りなく、かつ、手軽に注射でき、疼痛の少ない細い注射針を用いたときであっても迅速に注射できるタイプのキット製剤、及び、そのようなキット製剤を可能とするキット製剤用注射器を提供することを目的とする。 The present invention improves the above-described conventional problems, that is, simple and quick, error-free and easy injection, and can be quickly injected even when a thin needle with little pain is used. It is an object of the present invention to provide a kit preparation of a type and a syringe for a kit preparation that enables such a kit preparation.

本発明のキット製剤用注射器は上記課題を解決するため、請求項１に記載の通り、内部に薬液を保持する薬液室、前記薬液室の一方の端に、基部が前記薬液室に連通している注射針、前記薬液室の他方の端側に内部にコイルばねが収納された筒状のばね収納室、及び、前記コイルばねを圧縮した状態で保持しかつ注射動作時に前記コイルばねの圧縮を解除して前記コイルばねにより前記薬液室の前記薬液を前記注射針に供給させるばね圧縮解除手段、を備えていることを特徴とするキット製剤用注射器である。 In order to solve the above problems, the syringe for a kit preparation of the present invention has a chemical solution chamber for holding a chemical solution therein, a base at one end of the chemical solution chamber, and a base communicating with the chemical solution chamber. An injection needle, a cylindrical spring storage chamber in which a coil spring is stored inside the other end of the drug solution chamber, and the coil spring is held in a compressed state and the coil spring is compressed during an injection operation. A syringe for kit preparation characterized by comprising spring compression release means for releasing and supplying the drug solution in the drug solution chamber to the injection needle by the coil spring.

また、本発明のキット製剤用注射器は、請求項２に記載のように、請求項１に記載のキット製剤用注射器において、前記ばね収納室が前記薬液室と分離可能に設けられていることを特徴とする。 Moreover, the syringe for kit preparations of this invention is the syringe for kit preparations of Claim 1 as described in Claim 2, The said spring storage chamber is provided so that isolation | separation with the said chemical | medical solution chamber is possible. Features.

また、本発明のキット製剤用注射器は、請求項３に記載のように、請求項１または請求項２に記載のキット製剤用注射器において、前記コイルばねの注射針側先端付近に設けられた径が太い大径部が前記ばね収納室の内側面に設けられた凸部により係止されて前記コイルばねが圧縮した状態で保持されており、前記ばね圧縮解除手段として、前記コイルばねの前記大径部より前記先端側の部分を前記注射針側に移動させて前記大径部を縮径させて前記大径部の前記係止を解除させるコイルばね先端部操作部材が、前記ばね収納室に設けられていることを特徴とする。 Moreover, the syringe for kit preparations of this invention is the diameter provided in the injection needle side vicinity of the said coil spring in the syringe for kit preparations of Claim 1 or Claim 2, as described in Claim 3. The large-diameter portion is held by a convex portion provided on the inner surface of the spring storage chamber and the coil spring is compressed, and the large portion of the coil spring is used as the spring compression release means. A coil spring tip portion operating member that moves the tip side portion from the diameter portion toward the injection needle side to reduce the diameter of the large diameter portion and releases the locking of the large diameter portion is provided in the spring storage chamber. It is provided.

また、本発明のキット製剤用注射器は、請求項４に記載のように、請求項１または請求項２に記載のキット製剤用注射器において、前記ばね収納室の内側面に設けられた凸部に縁部が当接して係止される板状の当接板部材が前記コイルばねの注射針側先端にかつ前記コイルばね延伸方向に垂直に配置されて前記コイルばねが圧縮した状態で保持されており、前記ばね圧縮解除手段として、前記コイルばねに前記注射針方向の圧力を印加することにより前記板状の当接板部を変形させて前記係止を解除させる圧力印加操作部が前記ばね収納室に設けられていることを特徴とする。 Moreover, the syringe for kit preparations of this invention is a syringe for kit preparations of Claim 1 or Claim 2, as described in Claim 4, in the convex part provided in the inner surface of the said spring storage chamber. A plate-like abutting plate member that is brought into contact with the edge and locked is disposed at the tip of the coil spring on the injection needle side and perpendicular to the direction in which the coil spring extends, and the coil spring is held in a compressed state. And a pressure application operation part for deforming the plate-like contact plate part by applying a pressure in the direction of the injection needle to the coil spring as the spring compression release means to release the locking. It is provided in the chamber.

また、本発明のキット製剤用注射器は、請求項５に記載のように、請求項１または請求項２に記載のキット製剤用注射器において、前記ばね収納室の側面に設けられた貫通孔を通じて前記ばね収納室の外部から前記ばね収納室の内部に差し込まれた凸部に縁部が当接して係止される板状の当接板部材が前記コイルばねの注射針側先端にかつ前記コイルばね延伸方向に垂直に配置されて前記コイルばねが圧縮した状態で保持されており、前記ばね圧縮解除手段として、前記係止片を前記ばね収納室内から除去する係止片除去手段が設けられていることを特徴とする。 The kit preparation syringe according to the present invention, as described in claim 5, is the kit preparation injector according to claim 1 or 2, wherein the injection through the through-hole provided in the side surface of the spring storage chamber. A plate-like contact plate member whose edge is brought into contact with and locked to a convex portion inserted into the spring storage chamber from the outside of the spring storage chamber is formed at the distal end of the coil spring on the injection needle side and the coil spring. The coil spring is disposed in a state of being compressed in a direction perpendicular to the extending direction, and a locking piece removing means for removing the locking piece from the spring storage chamber is provided as the spring compression releasing means. It is characterized by that.

また、本発明のキット製剤用注射器は、請求項６に記載のように、請求項５に記載のキット製剤用注射器において、前記ばね収納室の外側面に前記注射針方向前後にスライド移動するスライダ部が設けられ、前記係止片除去手段が、前記スライダ部と前記貫通孔とに設けられたカム機構により、前記スライダ部が前記注射針方向にスライドされたときに前記係止片を駆動して前記ばね収納室内から除去する手段であることを特徴とする。 The kit preparation syringe according to the present invention is the kit preparation syringe according to claim 5, wherein the slider slides back and forth in the direction of the injection needle on the outer surface of the spring storage chamber. The locking piece removing means drives the locking piece when the slider portion is slid in the direction of the injection needle by a cam mechanism provided in the slider portion and the through hole. Means for removing from the spring storage chamber.

また、本発明のキット製剤用注射器は、請求項７に記載のように、請求項５に記載のキット製剤用注射器において、前記係止片除去手段が、前記係止片を有しかつ前記ばね収納室の外側面に接する主部と、該主部に連続して設けられかつ該主部から離れるに従い前記外側面から離間する操作部と、を有していることを特徴とする。 Moreover, the syringe for kit preparations of this invention is the syringe for kit preparations of Claim 5 as described in Claim 7, The said locking piece removal means has the said locking piece, and the said spring The main portion is in contact with the outer surface of the storage chamber, and the operation portion is provided continuously from the main portion and is separated from the outer surface as the distance from the main portion increases.

また、本発明のキット製剤用注射器は、請求項８に記載のように、請求項１ないし請求項７のいずれか１項に記載のキット製剤用注射器において、前記薬液室の前記ばね収納室側に、前記薬液室のばね収納室側を水密に封じる易破壊性の隔膜を有し、前記コイルばねの注射器針側先端に、前記隔膜を破壊するための隔膜破壊手段と、注射動作時に前記コイルばねにより駆動されて前記薬液室内側面に接しながら前記薬液を前記注射針に供給させる摺動部とを有することを特徴とする。 Moreover, the syringe for kit preparations of this invention is the syringe for kit preparations of any one of Claims 1 thru | or 7 as described in Claim 8, The said spring storage chamber side of the said chemical | medical solution chamber An easily breakable diaphragm for watertightly sealing the spring storage chamber side of the drug solution chamber, and a diaphragm breaking means for breaking the diaphragm at the syringe needle side tip of the coil spring, and the coil during the injection operation And a sliding portion that is driven by a spring to supply the drug solution to the injection needle while contacting the side surface of the drug solution chamber.

また、本発明のキット製剤用注射器は、請求項９に記載のように、請求項１ないし請求項７のいずれか１項に記載のキット製剤用注射器において、前記薬液室に、前記薬液室のばね収納室側を水密に封じ、かつ、注射動作時に前記コイルばねにより駆動されて前記薬液室内側面に接しながら前記薬液を前記注射針に供給させる摺動弁を有することを特徴とする。 Moreover, the syringe for kit preparations of this invention is the syringe for kit preparations of any one of Claims 1 thru | or 7 as described in Claim 9, In the said chemical | medical solution chamber, the said chemical | medical solution chamber contains the said chemical | medical solution chamber. It has a sliding valve that seals the spring storage chamber side in a watertight manner and is driven by the coil spring during injection operation to supply the drug solution to the injection needle while contacting the side surface of the drug solution chamber.

また、本発明のキット製剤は、請求項１０に記載のように、請求項１ないし請求項７のいずれか１項に記載のキット製剤用注射器を有し、
前記薬液室内に薬液が水密に充填された軟質樹脂材料製のフィルムからなる薬液パックを収納し、かつ、注射動作時に前記コイルばねにより前記薬液パックに圧力が印加された際に前記フィルムの少なくとも一部を切断するフィルム切断部を前記薬液室内面に有していることを特徴とするキット製剤である。 Moreover, the kit formulation of this invention has the syringe for kit formulation of any one of Claim 1 thru | or 7 as described in Claim 10,
A chemical pack made of a film made of a soft resin material filled with a chemical solution in a watertight manner is stored in the chemical solution chamber, and at least one of the films when a pressure is applied to the chemical pack by the coil spring during an injection operation. It is a kit preparation characterized by having a film cutting part for cutting the part on the inner surface of the chemical solution chamber.

また、本発明のキット製剤は、請求項１１に記載のように、請求項１０に記載のキット製剤において、前記薬液パックが前記注射針方向に対して垂直方向に突出する鍔部を全周に有し、前記薬液室が該鍔部の前後の２つの部材により構成されかつ前記２つの部材が組み合わされて前記薬液室が形成されているときに前記鍔部が前記２つの部材により挟持されて前記鍔部の前後が水密に区分されており、かつ、前記２つの部材のうちの注射針側の部材が前記フィルム切断部を有していることを特徴とする。 In addition, the kit preparation of the present invention is the kit preparation according to claim 10, wherein the kit pack according to the present invention is such that the liquid pack protrudes in a direction perpendicular to the direction of the injection needle on the entire circumference. And when the chemical chamber is configured by two members before and after the collar and the chemical chamber is formed by combining the two members, the collar is sandwiched by the two members. The front and rear of the collar portion are water-tightly divided, and a member on the injection needle side of the two members has the film cutting portion.

また、本発明のキット製剤は、請求項１２に記載の通り、請求項１ないし請求項９のいずれか１項に記載のキット製剤用注射器を有することを特徴とするキット製剤である。 Moreover, the kit formulation of this invention is a kit formulation characterized by having the syringe for kit formulations of any one of Claim 1 thru | or 9 as described in Claim 12.

また、本発明のキット製剤は、請求項１３に記載の通り、請求項１０ないし請求項１２のいずれか１項に記載のキット製剤用注射器において、前記注射針の先端を水密に保護する着脱可能なキャップを備えていることを特徴とする。 In addition, the kit preparation of the present invention is, as described in claim 13, detachable for protecting the tip of the injection needle in a watertight manner in the kit preparation syringe according to any one of claims 10 to 12. It is characterized by having a cap.

また、本発明のキット製剤は、請求項１４に記載の通り、請求項１１ないし請求項１３のいずれか１項に記載のキット製剤において、前記注射針を複数有していることを特徴とする。 Moreover, the kit formulation of this invention has multiple said injection needles in the kit formulation of any one of Claim 11 thru | or 13, as described in Claim 14, It is characterized by the above-mentioned. .

本発明のキット製剤は請求項１５に記載の通り、請求項１１ないし請求項１４のいずれか１項に記載のキット製剤において、インフルエンザウィルス皮下注射用キット製剤であることを特徴とする。 As described in claim 15, the kit preparation of the present invention is characterized in that it is a kit preparation for influenza virus subcutaneous injection in the kit preparation of any one of claims 11 to 14.

本発明のキット製剤用注射器によれば、簡易にかつ迅速に、誤りなく、かつ、手軽に薬液を注射できる。さらに、軽量化や低コスト化が容易で、使い捨てにでき、片手でも扱いやすい。また、疼痛の少ない細い注射針を用いた場合であっても強力なコイルスプリングを用いることで注射動作が迅速に終了するので、被投与者と投与者との負担が少ない。 According to the syringe for kit preparation of the present invention, it is possible to easily and quickly inject a drug solution easily and without error. Furthermore, it is easy to reduce weight and cost, can be disposable, and is easy to handle with one hand. Further, even when a thin injection needle with little pain is used, the injection operation is quickly completed by using a strong coil spring, so that the burden on the recipient and the recipient is small.

図１は本発明に係るキット製剤用注射器の第１の例を示すモデル図である。（ａ）外観を示すモデル斜視図である。（ｂ）キット製剤用注射器の第１の例において用いるコイルばねを示すモデル斜視図である。（ｃ）組み立て前の状態を示すモデル断面図と、部分拡大モデル断面図である。（ｄ）組み立て後の状態を示すモデル断面図と、部分拡大モデル断面図である。FIG. 1 is a model diagram showing a first example of a syringe for kit preparation according to the present invention. (A) It is a model perspective view which shows an external appearance. (B) It is a model perspective view which shows the coil spring used in the 1st example of the syringe for kit preparations. (C) It is model sectional drawing which shows the state before an assembly, and a partial expansion model sectional drawing. (D) It is a model cross section which shows the state after an assembly, and a partial expansion model cross section. 図２は本発明に係るキット製剤用注射器の第１の例を示すモデル図である。（ａ）操作時の状態を示すモデル断面図である。（ｂ）注射動作直前の状態を示すモデル断面図である。（ｃ）注射動作終了後の状態を示すモデル断面図である。FIG. 2 is a model diagram showing a first example of a syringe for kit preparation according to the present invention. (A) It is a model sectional view showing the state at the time of operation. (B) It is a model sectional view showing the state just before injection operation. (C) It is model sectional drawing which shows the state after completion | finish of injection operation | movement. 図３は容量の大きな薬液室の例を示すモデル断面図である。FIG. 3 is a model cross-sectional view showing an example of a chemical chamber having a large capacity. 図４は摺動部及び板状の当接板部材の例を示すモデル斜視図（とモデル断面図）である。（ａ）キット製剤用注射器の第１の例で用いる摺動部のモデル斜視図である。（ｂ）他の摺動部のモデル斜視図とモデル断面図である。（ｃ）板状の当接板部材の１例のモデル斜視図である。（ｄ）板状の当接板部材の他の例のモデル斜視図とモデル断面図である。FIG. 4 is a model perspective view (and model cross-sectional view) showing an example of a sliding portion and a plate-like contact plate member. (A) It is a model perspective view of the sliding part used in the 1st example of the syringe for kit preparations. (B) The model perspective view and model sectional drawing of another sliding part. (C) It is a model perspective view of an example of a plate-shaped contact plate member. (D) It is a model perspective view and model sectional view of other examples of a plate-like contact board member. 図５は本発明に係るキット製剤用注射器の第２の例を示すモデル図である。（ａ）薬液室の組み立て前の状態を示すモデル断面図である。（ｂ）組み立て後の薬液室の状態を示すモデル断面図と、部分拡大モデル断面図である。（ｃ）組み立て後の状態を示すモデル断面図である。（ｄ）注射動作直前の状態を示すモデル断面図である。FIG. 5 is a model diagram showing a second example of the kit preparation syringe according to the present invention. (A) It is model sectional drawing which shows the state before the assembly of a chemical | medical solution chamber. (B) It is a model cross section which shows the state of the chemical | medical solution chamber after an assembly, and a partial expanded model cross section. (C) It is model sectional drawing which shows the state after an assembly. (D) It is a model sectional view showing the state just before injection operation. 図６は本発明に係るキット製剤用注射器の第２の例を示すモデル図である。（ａ）注射動作開始直後の状態を示すモデル断面図である。（ｂ）注射動作終了後の状態を示すモデル断面図である。（ｃ）薬液室部材の他の例を示すモデル断面図とその部分拡大モデル断面図である。FIG. 6 is a model diagram showing a second example of the kit preparation syringe according to the present invention. (A) It is a model sectional view showing the state immediately after the start of injection operation. (B) It is a model sectional view showing the state after completion of injection operation. (C) It is the model cross section which shows the other example of a chemical | medical solution chamber member, and its partial expanded model cross section. 図７は本発明に係るキット製剤用注射器の第３の例を示すモデル断面図である。（ａ）組み立て前の状態を示すモデル断面図である。（ｂ）組み立て後の状態を示すモデル断面図である。（ｃ）注射動作直前の状態を示すモデル断面図である。（ｄ）注射動作終了後の状態を示すモデル断面図である。FIG. 7 is a model sectional view showing a third example of the syringe for kit preparation according to the present invention. (A) It is model sectional drawing which shows the state before an assembly. (B) It is model sectional drawing which shows the state after an assembly. (C) It is a model sectional view showing the state just before injection operation. (D) It is a model sectional view showing the state after completion of injection operation. 図８は本発明に係るキット製剤用注射器の第４の例を示すモデル図である。（ａ）組み立て前の状態を示すモデル断面図である。（ｂ）係止片により当接板部材が係止されている状態を示す部分拡大モデル断面図である。（ｃ）運搬状態を示すモデル断面図である。FIG. 8 is a model diagram showing a fourth example of the kit preparation syringe according to the present invention. (A) It is model sectional drawing which shows the state before an assembly. (B) It is a partial expanded model sectional view showing the state where the contact plate member is locked by the locking piece. (C) It is model sectional drawing which shows a conveyance state. 図９は本発明に係るキット製剤用注射器の第４の例を示すモデル図である。（ａ）スライド防止Ｃリングを示す斜視図である。（ｂ）スライド防止Ｃリングを除去した状態を示すモデル断面図である。（ｃ）カム機構により係止片が駆動されて当接板部材の係止が解除された状態を示す部分拡大モデル断面図である。（ｄ）注射動作直前の状態を示すモデル断面図である。FIG. 9 is a model diagram showing a fourth example of the kit preparation syringe according to the present invention. (A) It is a perspective view which shows a slide prevention C ring. (B) It is model sectional drawing which shows the state which removed the slide prevention C ring. (C) It is a partial expanded model sectional view showing the state where the locking piece was driven by the cam mechanism, and the locking of the contact plate member was released. (D) It is a model sectional view showing the state just before injection operation. 図１０は本発明に係るキット製剤用注射器の第５の例を示すモデル図である。（ａ）組み立て前の状態を示すモデル断面図である。（ｂ）組み立て後の状態を示すモデル断面図である。（ｃ）操作部が操作されて、注射動作開始直前の状態を示すモデル断面図である。FIG. 10 is a model diagram showing a fifth example of the kit preparation syringe according to the present invention. (A) It is model sectional drawing which shows the state before an assembly. (B) It is model sectional drawing which shows the state after an assembly. (C) It is model sectional drawing which shows the state just before an injection operation start by operating an operation part.

本発明のキット製剤用注射機について、以下、図面を用いて説明する。
図１及び図２は本発明に係るキット製剤用注射器の第１の例を説明するモデル図であり、図１（ａ）は外観を示すモデル斜視図である。 Hereinafter, the injection device for kit preparation of the present invention will be described with reference to the drawings.
1 and 2 are model views for explaining a first example of the kit preparation syringe according to the present invention, and FIG. 1 (a) is a model perspective view showing an appearance.

このキット製剤用注射器は、注射針３を薬液室２０の一方の端側に４本備えている。この例では皮下注射用の注射針で、薬液室２０先端からの注射針先端までの長さが１５ｍｍであり、ゲージ（注射針太さ）は３３ゲージである。このような細い注射針であるために、注射時の疼痛は比較的小さい。このような細い針を用いた場合、一般に注射動作が長くなるが、本発明では強力なコイルばねを用いることで迅速に行うことができる。さらに、図示するように４本の注射針で注射するために注射動作をより早く終了させることができる。また、より細い注射針、例えば３６ゲージのものを用いることもできる。また、上記注射針露出部長さは１５ｍｍとしたが、皮下注射が可能な長さ（例えば１０ｍｍ、５ｍｍ、３ｍｍ）等、短くても、あるいは長くても良く、適宜選択することができる The kit preparation syringe includes four injection needles 3 on one end side of the drug solution chamber 20. In this example, it is a hypodermic needle, the length from the tip of the drug chamber 20 to the tip of the needle is 15 mm, and the gauge (thickness of the needle) is 33 gauge. Because of such a thin injection needle, pain during injection is relatively small. When such a thin needle is used, the injection operation is generally prolonged, but in the present invention, it can be performed quickly by using a strong coil spring. Further, since the injection is performed with four injection needles as shown in the drawing, the injection operation can be finished earlier. A thinner needle, for example, a 36 gauge one can also be used. Further, the length of the exposed portion of the injection needle is 15 mm, but it may be short or long, such as a length allowing subcutaneous injection (for example, 10 mm, 5 mm, 3 mm), and can be appropriately selected.

４本の注射針３の基部は、図１（ｃ）の右側に示されるように、薬液室２０に連通している。また、薬液室２０のばね収納室１０側に、薬液室２０のばね収納室１０側を水密に封じる易破壊性の隔膜２０ｂが設けられている。 The bases of the four injection needles 3 communicate with the drug solution chamber 20 as shown on the right side of FIG. Further, an easily destructible diaphragm 20b is provided on the spring storage chamber 10 side of the chemical solution chamber 20 to seal the chemical storage chamber 20 side of the spring storage chamber 10 in a watertight manner.

ここで、易破壊性の隔膜２０ｂは、例えば熱可塑性樹脂フィルムが積層されたアルミニウム箔などから構成することができ、その熱可塑性樹脂フィルム層により薬液室２０のばね収納室１０側に熱融着させて上記の水密状態を達成することができる。 Here, the easily breakable diaphragm 20b can be composed of, for example, an aluminum foil or the like on which a thermoplastic resin film is laminated, and the thermoplastic resin film layer is thermally fused to the spring storage chamber 10 side of the chemical chamber 20. Thus, the above watertight state can be achieved.

一方、上述のように、薬液室２０には注射針３が連通しているために薬液室２０内の薬液１は保管や運搬時に注射針３を通じて外部に漏出する恐れがあるが、図１（ｃ）に示すような、注射針３の先端を水密に保護する着脱可能なキャップ２を備えることで、このような薬液１の漏出を防ぐことができ、同時に注射針３を保護することができる。このようなキャップ２は注射操作開始前に除去する。 On the other hand, as described above, since the injection needle 3 communicates with the chemical solution chamber 20, the chemical solution 1 in the chemical solution chamber 20 may leak outside through the injection needle 3 during storage or transportation. By providing the removable cap 2 that protects the tip of the injection needle 3 in a water-tight manner as shown in c), it is possible to prevent such leakage of the drug solution 1 and at the same time protect the injection needle 3. . Such a cap 2 is removed before the start of the injection operation.

薬液室２０の注射針３側側面の後述する摺動部６０の凸部６０ｂに相当する位置には、後述する凹部２０ｃが設けられている A concave portion 20c described later is provided at a position corresponding to a convex portion 60b of a sliding portion 60 described later on the side surface of the drug solution chamber 20 on the injection needle 3 side.

薬液室２０の他方の端側（この例では操作側）には、内部にコイルばね５０が収容された筒状のばね収納部１０が、ばね収納部１０の雄ねじ１０ａと薬液室２０の雌ねじ２０ａにより接続されて一体となっている（図１（ｃ）及び（ｄ）参照）。なお、薬液室２０とばね収納部１０とを分離可能とすることにより、製造が容易になる他、実際に注射に用いる直前まで両者を分離しておくことにより、コイルばねの誤作動による薬液の損失を未然に防止することができる。 On the other end side (the operation side in this example) of the chemical chamber 20, a cylindrical spring accommodating portion 10 in which a coil spring 50 is accommodated is a male screw 10 a of the spring accommodating portion 10 and a female screw 20 a of the chemical chamber 20. Are connected and integrated (see FIGS. 1C and 1D). In addition to making the chemical chamber 20 and the spring storage portion 10 separable, manufacturing is facilitated, and by separating the two until just before actually using the injection, the chemical solution due to malfunction of the coil spring can be obtained. Loss can be prevented in advance.

ばね収納部１０に収納されているコイルばね５０は、その薬液室２０側の先端近くに太径となった太径部５０ｂが設けられ、この太径部５０ｂよりもさらに薬液室２０側には先端に向かうにつれて径が細くなる徐細径部５０ａが設けられている（図１（ｂ）参照）。徐細径部５０ａの先端は摺動部６０（図４（ａ）にその斜視図を示す）の操作側に設けられた細径部６０ａ周囲に巻き付いて係止されており、徐細径部５０ａの先端は、摺動部６０の動き（図中左右方向の動き）に従うようになっている。 The coil spring 50 accommodated in the spring accommodating portion 10 is provided with a large diameter portion 50b having a large diameter near the tip on the side of the chemical solution chamber 20, and further on the chemical solution chamber 20 side than the large diameter portion 50b. A gradually narrowing diameter portion 50a is provided that decreases in diameter toward the tip (see FIG. 1B). The tip of the gradually narrowing portion 50a is wound around and locked to the periphery of the narrow diameter portion 60a provided on the operation side of the sliding portion 60 (the perspective view of which is shown in FIG. 4A). The tip of 50a follows the movement of the sliding portion 60 (movement in the left-right direction in the figure).

摺動部６０はこの例では円板（円盤）形状で、後述するように注射動作中にはコイルばね５０により注射針３側に駆動されて、易破壊性の隔膜２０ｂをその注射針側面の中央に設けられた円錐型の凸部６０ｂにより破き、さらに薬液室２０の内側面に摺動しつつ薬液室２０内の薬液１を注射針３に供給する。 In this example, the sliding portion 60 has a disc shape and is driven to the side of the injection needle 3 by the coil spring 50 during the injection operation, as will be described later, so that the easily breakable diaphragm 20b is placed on the side surface of the injection needle. The drug solution 1 in the drug solution chamber 20 is supplied to the injection needle 3 while being broken by the conical convex portion 60 b provided in the center and sliding on the inner surface of the drug solution chamber 20.

コイルばね５０の太径部５０ｂは、図１（ｃ）の二点鎖線部分を部分拡大した、図中右上の部分拡大モデル断面図に示したように、ばね収納部１０の内側面に設けられた凸部１０ｂにより係止されており、コイルばね５０の太径部５０ｂより図中右側部分は圧縮された状態でばね収納部１０に収納されている。 The large-diameter portion 50b of the coil spring 50 is provided on the inner surface of the spring accommodating portion 10 as shown in the partially enlarged model cross-sectional view in the upper right in the drawing, in which the two-dot chain line portion in FIG. The right portion in the figure is stored in the spring storage portion 10 in a compressed state from the large diameter portion 50b of the coil spring 50.

ばね収納部１０の操作側（図中右側）には、操作部４０ａ、後述する摺動部６０に当接している当接面４０ｄ、及び、これらを接続する接続軸４０ｂからなる操作部材４０が設けられている。接続軸４０ｂは、ばね収納部１０の操作側の面１０ｂに設けられてばね収納部１０内部へ貫通している挿入孔１０ｃに挿入されている。接続軸４０ｂの側面には、図１（ｄ）の二点鎖線部分を部分拡大した図中右上の部分拡大モデル断面図に示したように、突出部４０ｃが設けられ、挿入孔１０ｃの縁部に係止されて抜け止めされているので、操作部材４０の亡失が未然に防止されている。 On the operation side (right side in the drawing) of the spring storage unit 10, there is an operation member 40 including an operation unit 40 a, a contact surface 40 d that is in contact with a sliding unit 60 described later, and a connecting shaft 40 b that connects them. Is provided. The connecting shaft 40 b is inserted into an insertion hole 10 c provided on the operation side surface 10 b of the spring storage portion 10 and penetrating into the spring storage portion 10. On the side surface of the connecting shaft 40b, as shown in the partially enlarged model cross-sectional view in the upper right in the drawing in which the two-dot chain line portion in FIG. Therefore, the operation member 40 is prevented from being lost.

このようなキット製剤の動作について図２を用いて説明する。
操作者は、注射針３を被注射部位に刺し、次いで操作部材４０の操作部４０ａを図２（ａ）の矢印方向に押す。その動きは接続軸４０と当接面４０ｄとにより伝わり、摺動部６０を注射針側に移動させると同時に徐細径部５０ａの先端も注射針３側に移動する。その結果、徐細径部５０ａ及び太径部５０ｂは延伸されて、本来の太さよりも細くなり、太径部５０ｂの凸部１０ｂによる係止は解除される。このようにして係止が解除されたコイルばね５０は図２（ｂ）（注射動作直前の状態を示すモデル断面図である。）に示すように摺動部６０を注射針３側へ駆動しつつ自らは延伸する。 The operation of such a kit preparation will be described with reference to FIG.
The operator pierces the injection site 3 with the injection needle 3 and then pushes the operation portion 40a of the operation member 40 in the direction of the arrow in FIG. The movement is transmitted by the connecting shaft 40 and the contact surface 40d, and the sliding portion 60 is moved to the injection needle side, and at the same time, the tip of the gradually narrow diameter portion 50a is also moved to the injection needle 3 side. As a result, the gradually-thinned diameter portion 50a and the large-diameter portion 50b are stretched to become thinner than the original thickness, and the locking by the convex portion 10b of the large-diameter portion 50b is released. The coil spring 50 thus unlocked drives the sliding portion 60 toward the injection needle 3 as shown in FIG. 2B (a model sectional view showing a state immediately before the injection operation). While extending itself.

さらに、摺動部６０は、注射針３側に駆動されてその先端の円錐型の凸部６０ｂにより易破壊性の隔膜２０ｂを破き、さらに薬液室２０の内側面に摺動しつつ薬液室２０内の薬液１を注射針３に供給する。 Further, the sliding portion 60 is driven to the injection needle 3 side, breaks the easily destructible diaphragm 20b by the conical convex portion 60b at the tip, and further slides on the inner surface of the chemical liquid chamber 20 while the chemical liquid chamber. The chemical solution 1 in 20 is supplied to the injection needle 3.

図２（ｃ）は注射動作終了後の状態を示すモデル断面図である。図示するように円錐型の凸部６０ｂは、薬液室２０の注射針側の面に設けられた凹部２０ｃに位置することで薬液室２０内の薬液全量が注射針３に供給される。 FIG.2 (c) is model sectional drawing which shows the state after completion | finish of injection operation | movement. As shown in the figure, the conical convex portion 60 b is positioned in a concave portion 20 c provided on the surface of the drug solution chamber 20 on the injection needle side, whereby the total amount of the drug solution in the drug solution chamber 20 is supplied to the injection needle 3.

このような注射器において、薬液室内の薬液の容量は、コイルばねによる駆動エネルギーにより注射液が全量、注射針に供給される範囲において、例えば図４に示す薬液室２１のように大きいものであっても良い。 In such a syringe, the volume of the drug solution in the drug solution chamber is large as in the drug solution chamber 21 shown in FIG. 4, for example, in a range in which the injection solution is supplied to the injection needle by the drive energy of the coil spring. Also good.

図４（ａ）には上記キット製剤用注射器の第１の例で用いる摺動部のモデル斜視図を示した。ここで円錐型の凸部６０ｂを中央に有する代わりに、図４（ｂ）にモデル斜視図とモデル断面図を示したように、円板状体の注射針側の面の周辺に刃状部６１ｂ設けた摺動部６１を用いることで易破壊性の隔膜２０ｂの破壊とともに薬液室２０のばね収納室１０側の端部からの易破壊性の隔膜２０ｂの除去が可能となり、このとき摺動部６１の駆動の妨げとならないために注射動作がよりスムーズなものとなる。 FIG. 4 (a) shows a model perspective view of a sliding portion used in the first example of the kit preparation syringe. Here, instead of having the conical convex portion 60b in the center, as shown in the model perspective view and the model cross-sectional view in FIG. 4B, the blade-like portion is provided around the surface on the injection needle side of the disc-like body. By using the sliding portion 61 provided in 61b, it is possible to remove the easily breakable diaphragm 20b from the end of the chemical chamber 20 on the spring storage chamber 10 side as well as to break the easily breakable diaphragm 20b. Since the driving of the part 61 is not hindered, the injection operation becomes smoother.

図５には、本発明に係るキット製剤用注射器の第２の例を示すモデル図を示した。
上記のキット製剤用注射器の第１の例では、注射動作の過程で薬液室２０の薬液１がばね収納室側に漏出する恐れがあったが、この第２の例では、そのような漏出が防止されている。この例は上記第１の例と基本的には同じばね収納室１０を用いているために、相違点のみを説明する。 In FIG. 5, the model figure which shows the 2nd example of the syringe for kit formulations which concerns on this invention was shown.
In the first example of the kit preparation syringe described above, there is a risk that the chemical solution 1 in the chemical solution chamber 20 leaks to the spring storage chamber side in the course of the injection operation, but in this second example, such leakage is It is prevented. Since this example uses the same spring storage chamber 10 as the first example, only the differences will be described.

図５（ａ）には薬液室２２の組み立て前の状態を示すモデル断面図である。
薬液室２２は、注射針３を有する注射針側部材２２ａ、薬液１が水密に充填された軟質樹脂材料製（例えばポリオレフィンやポリプロピレン製）のフィルムからなる薬液パック４、及び、側面部材２２ｂから構成される。 FIG. 5A is a model cross-sectional view showing a state before the chemical chamber 22 is assembled.
The drug solution chamber 22 includes an injection needle side member 22a having an injection needle 3, a drug solution pack 4 made of a film made of a soft resin material (for example, polyolefin or polypropylene) filled with the drug solution 1 in a watertight manner, and a side member 22b. Is done.

この例では注射針３を４本有する注射針側部材２２ａの側面には上記側面部材２２ｂの雌ねじ部２２ｂ１に螺合する雄ねじ部２２ａ１が設けられている。注射針側部材２２ａのばね収納部側の面には注射動作時にコイルばねにより薬液パック４に圧力が印加された際に薬液パック４のフィルムの少なくとも一部を切断して孔を開けるための鋭利な凸部２２ａ３がフィルム切断部として設けられている。 In this example, a male screw portion 22a1 that is screwed into the female screw portion 22b1 of the side member 22b is provided on the side surface of the injection needle side member 22a having four injection needles 3. The surface on the spring accommodating portion side of the injection needle side member 22a is sharp for cutting at least a part of the film of the drug solution pack 4 when a pressure is applied to the drug solution pack 4 by a coil spring during the injection operation. Convex part 22a3 is provided as a film cutting part.

側面部材２２ｂの注射針側には上述の雌ねじ部２２ｂ１、及び、ばね収納室側には、ばね収納室１０の雌ねじ部と螺合する雄ねじ部２２ｂ２が設けられている。 On the side of the side member 22b, the above-described female screw portion 22b1 is provided, and on the spring storage chamber side, a male screw portion 22b2 that engages with the female screw portion of the spring storage chamber 10 is provided.

薬液パック４には注射針３方向に対して垂直方向に突出する鍔部４ａが全周に設けられている。鍔部の前後４ａの２つの部材である注射針側部材２２ａと側面部材２２ｂとが組み合わされて、図５（ｂ）の左側の図、及び、その二点鎖線からなる円で示された領域の部分拡大モデル断面図である右側の図に示されるように、薬液室２２が形成されているときに、鍔部４ａが２つの部材である注射針側部材２２ａと側面部材２２ｂとにより挟持されて、鍔部４ａの前後が水密に区分されている。 The drug solution pack 4 is provided with a collar 4a protruding in the direction perpendicular to the direction of the injection needle 3 on the entire circumference. The region shown by the circle on the left side of FIG. 5 (b) and its two-dot chain line, in which the injection needle side member 22a and the side member 22b, which are two members of the front and rear 4a of the buttocks, are combined. As shown in the drawing on the right side, which is a partial enlarged model sectional view, when the drug chamber 22 is formed, the collar portion 4a is sandwiched between the injection needle side member 22a and the side member 22b which are two members. Thus, the front and back of the collar portion 4a are watertight.

図５（ｃ）に、このような薬液室２２をばね収納室１０に接続し、キット製剤とした状態のモデル断面図を示した。
この例では、ばね収納室１０内には図１における摺動部６０ではなく、図４（ｃ）に斜視図を示す、注射針３側が平面で、操作側には、コイルばね５０の徐細径部５０ａの先端が巻き付いて係止される細径部６２ａが設けられている板状の当接板部材６２を有している。 FIG. 5C shows a model cross-sectional view in a state where such a chemical solution chamber 22 is connected to the spring storage chamber 10 to form a kit preparation.
In this example, not the sliding portion 60 in FIG. 1 but the perspective view of FIG. 4C is shown in the spring housing chamber 10, and the injection needle 3 side is a flat surface, and the coil spring 50 is gradually thinned on the operation side. It has a plate-like contact plate member 62 provided with a small diameter portion 62a around which the tip of the diameter portion 50a is wound and locked.

ここで、操作者が操作部材４０の操作部４０ａを図中矢印方向に操作することにより、上記同様にコイルばね５０は延伸して、板状の当接板部材６２を注射針３側へ駆動する。板状の当接板部材６２は薬液パック４のばね収納室１０側の面に当接して薬液パック４を注射針３側に付勢する。このとき、薬液パック４の注射針３側の面は凸部２２ａ３に突き刺さって切断され（図６（ａ）参照）、薬液パック４内の薬液１は、注射針３に供給されて注射に供せられる。板状の当接板部材６２はコイルばね５０により、さらに注射針３側に駆動されて、薬液室２２内の薬液１は全量注射される（図５（ｂ）参照）。 Here, when the operator operates the operation portion 40a of the operation member 40 in the direction of the arrow in the figure, the coil spring 50 is extended in the same manner as described above, and the plate-like contact plate member 62 is driven toward the injection needle 3 side. To do. The plate-like contact plate member 62 abuts against the surface of the drug solution pack 4 on the spring storage chamber 10 side and biases the drug solution pack 4 toward the injection needle 3 side. At this time, the surface of the medicinal solution pack 4 on the injection needle 3 side is pierced and cut into the convex portion 22a3 (see FIG. 6A), and the medicinal solution 1 in the medicinal solution pack 4 is supplied to the injection needle 3 and used for injection. It is made. The plate-like contact plate member 62 is further driven to the injection needle 3 side by the coil spring 50, and the entire amount of the chemical solution 1 in the chemical solution chamber 22 is injected (see FIG. 5B).

上記では凸部２２ａ３は注射針側部材２２ａのばね収納部側面から突出して設けられていたが、この場合、注射操作以前の運搬などで凸部２２ａ３が薬液パック４を破る恐れがある。ここで、図６（ｃ）に示すように注射針側部材２２ａの代わりに注射針側部材２２ｃ（二点鎖線部分の部分拡大モデル断面図を図中右側に示す）のように、ばね収納部側面にくぼみ２２ｃ４を設け、その中に凸部２２ｃ３を設けることで運搬中に凸部により薬液パックを破る事故を予防できる。 In the above description, the convex portion 22a3 is provided so as to protrude from the side surface of the spring accommodating portion of the injection needle side member 22a. However, in this case, the convex portion 22a3 may break the liquid medicine pack 4 due to transportation before the injection operation. Here, as shown in FIG. 6 (c), instead of the injection needle side member 22a, a spring storage portion as shown in the injection needle side member 22c (a partially enlarged model cross-sectional view of the two-dot chain line portion is shown on the right side in the drawing). By providing the recess 22c4 on the side surface and providing the convex portion 22c3 therein, it is possible to prevent an accident that breaks the chemical pack by the convex portion during transportation.

図７に、本発明に係るキット製剤用注射器の第３の例を示す。
図７（ａ）は組み立て前の状態を示すモデル断面図である。
薬液室２３には、図１における薬液室２０の易破壊性の隔膜２０ｂに代えて摺動弁５を有する。この摺動弁５は、ばね収納室１１のばね５１により駆動されて薬液室２３の内側面を水密に摺動しながら、注射針３側へ移動可能となっている。なお、真空打栓装置を用いることで、図示されているように薬液１が充填された状態で気体の混在なしに摺動弁をセットできる。 FIG. 7 shows a third example of the kit preparation syringe according to the present invention.
FIG. 7A is a model cross-sectional view showing a state before assembly.
The chemical chamber 23 has a sliding valve 5 instead of the easily breakable diaphragm 20b of the chemical chamber 20 in FIG. The sliding valve 5 is driven by the spring 51 of the spring storage chamber 11 and can move to the injection needle 3 side while sliding on the inner surface of the drug solution chamber 23 in a watertight manner. In addition, by using a vacuum stopper device, the sliding valve can be set without mixing gas in a state where the chemical solution 1 is filled as shown in the drawing.

一方、ばね収納室１１の内部の操作側の端（この例では図中右端）に圧力印加操作部として操作部材４１があり、その操作部４１ａはばね収納室１１の貫通孔１１ｃを通じてばね収納室１１外部に突出している。操作部材４１の注射針３方向端は若干小径となった小径部４１が設けられ、小径部４１はコイルばね５１の内部に挿入されている。コイルばね５１の注射針３側の端付近は先端に向かって徐々に細くなる徐細径部５１ａとなっており、その先端は、図４（ｄ）に、モデル斜視図及びモデル断面図を示す板状の当接板部材６３の小径部６３ｄに嵌合している。 On the other hand, an operation member 41 is provided as a pressure application operation portion at an operation side end (in this example, the right end in the figure) inside the spring storage chamber 11, and the operation portion 41 a passes through the through hole 11 c of the spring storage chamber 11. 11 protrudes to the outside. A small-diameter portion 41 having a slightly smaller diameter is provided at the end of the operation member 41 in the direction of the injection needle 3, and the small-diameter portion 41 is inserted into the coil spring 51. The vicinity of the end of the coil spring 51 on the side of the injection needle 3 is a gradually narrowing portion 51a that gradually decreases toward the tip, and the tip is shown in a model perspective view and a model cross-sectional view in FIG. A small diameter portion 63 d of the plate-like contact plate member 63 is fitted.

板状の当接板部材６３には、図４（ｄ）に示されるように本体部６３ｃの注射針３側に細径の溝部６３ａを介して本体部６３ｃと同径の補助部６３ｂが設けられている。この構成により、板状の当接板部材６３は、その軸がばね収納室１１と同軸に確実に保たれるので、板状の当接板部材６３はスムーズにばね収納室１１内を移動できる。ばね収納室１１の内側面に設けられた凸部１１ｂにこの板状の当接板部材６３の本体部６３ｃの縁部が当接して板状の当接板部材６３は係止されており、このためにコイルばね５１は板状の当接板部材６３によりばね収納部１１内で圧縮した状態で保持されている。 As shown in FIG. 4D, the plate-like contact plate member 63 is provided with an auxiliary portion 63b having the same diameter as that of the main body portion 63c via a small-diameter groove portion 63a on the injection needle 3 side of the main body portion 63c. It has been. With this configuration, the axis of the plate-like contact plate member 63 is reliably maintained coaxially with the spring storage chamber 11, so that the plate-like contact plate member 63 can smoothly move within the spring storage chamber 11. . The edge of the main body 63c of the plate-like contact plate member 63 comes into contact with the convex portion 11b provided on the inner surface of the spring storage chamber 11, and the plate-like contact plate member 63 is locked. For this purpose, the coil spring 51 is held in a compressed state in the spring accommodating portion 11 by a plate-like contact plate member 63.

注射操作時には操作者は、注射針３を被注射部位に刺し、次いで操作部材４１の操作部４１ａを図７（ｂ）中の矢印方向に押す。 At the time of injection operation, the operator stabs the injection needle 3 into the injection site, and then pushes the operation portion 41a of the operation member 41 in the direction of the arrow in FIG.

このとき、コイルばね５１に注射針３方向の圧力が印加されることにより、板状の当接板部６３の本体部６３ｃの縁部が変形して凸部１１ｂを乗り越え、コイルばね５１により板状の当接板部６３は注射針３側へ駆動される。 At this time, when the pressure in the direction of the injection needle 3 is applied to the coil spring 51, the edge of the main body portion 63 c of the plate-like contact plate portion 63 is deformed and gets over the convex portion 11 b, and the plate is pressed by the coil spring 51. The abutment plate portion 63 is driven toward the injection needle 3 side.

板状の当接板部６３は、薬液室２０の摺動弁５に当接後（図７（ｃ）参照）、摺動弁５を注射針３側に駆動し、摺動弁５により薬液１は注射針３に供給され、その後、注射動作は完了する（図７（ｄ）参照）。 The plate-like contact plate portion 63 contacts the sliding valve 5 in the chemical solution chamber 20 (see FIG. 7C), and then drives the sliding valve 5 to the injection needle 3 side. 1 is supplied to the injection needle 3, and then the injection operation is completed (see FIG. 7D).

ここで、図７（ａ）に示されるように、この例では板状の当接板部材６３の位置は注射針３に近い位置で係止されており、そして、コイルばねは比較的緩い条件で圧縮されているために、注射動作はショックなく進行する。 Here, as shown in FIG. 7A, in this example, the plate-like contact plate member 63 is locked at a position close to the injection needle 3, and the coil spring is relatively loose. The injection operation proceeds without shock.

上記では、ばね収納室の注射針側とは反対側に操作部が設けられて例を示したが、次にばね収納室の側面に操作部が設けられている例について説明する。 In the above description, the operation unit is provided on the side opposite to the injection needle side of the spring storage chamber. However, an example in which the operation unit is provided on the side surface of the spring storage chamber will be described below.

図８は、本発明に係るキット製剤用注射器の第４の例を示すモデル図であり、図８（ａ）は組み立て前の状態を示すモデル断面図である。 FIG. 8 is a model diagram showing a fourth example of the kit preparation syringe according to the present invention, and FIG. 8A is a model sectional view showing a state before assembly.

薬液室２３は、図７で示した薬液室２３と同じものであるので詳細な説明を省略する。有底円筒状のばね収納室１２ａの注射針３側開放端付近には、薬液室２３と接続するための雌ねじ２１ａ１が設けられている。円筒状のばね収納室１２ａの側面には円筒形のスライダ１２ｂが図中左右方向にスライド可能に外挿されている。（ただし、この図の状態ではスライド防止Ｃリング６（モデル斜視図を図９（ａ）に示す）によりスライド移動が防止されている。） The chemical liquid chamber 23 is the same as the chemical liquid chamber 23 shown in FIG. In the vicinity of the open end of the bottomed cylindrical spring storage chamber 12a on the injection needle 3 side, a female screw 21a1 for connection with the drug solution chamber 23 is provided. A cylindrical slider 12b is slidably inserted on the side surface of the cylindrical spring storage chamber 12a so as to be slidable in the left-right direction in the figure. (However, in the state of this figure, sliding movement is prevented by the anti-slide C-ring 6 (a model perspective view is shown in FIG. 9A).)

円筒形のスライダ１２ｂとしては、ばね収納室１２ａに外挿するために一部切欠き部があるものであっても良い。また、スライダは円筒形でなくても、例えば、ばね収納室１２ａの側面にガイドを設ける等の手段により、注射針３方向前後にスライド可能なスライダ部であれば良い。 The cylindrical slider 12b may have a partially cutout portion for extrapolation into the spring storage chamber 12a. Further, the slider may not be cylindrical but may be a slider portion that can slide back and forth in the direction of the injection needle 3 by means such as providing a guide on the side surface of the spring storage chamber 12a.

ばね収納室１２ａ内に、図中左右に移動可能な板状の当接板部材６２（図４（ｃ）参照）があるが、図８（ａ）の二点鎖線部分を拡大した部分拡大モデル断面図である図８（ｂ）に示されるように、ばね収納室１２ａの側面に設けられた貫通孔１２ａ１を通じてばね収納室１２ａの外部からばね収納室１２ａの内部に差し込まれた凸部である係止片７に板状の当接板部材６２の縁部が当接して板状の当接板部材６２が係止されている。このために板状の当接板部材６２の図中右側に配置された円錐コイルばね６２（太径部が注射針３側になるように配置）は圧縮された状態で保持されている。このような円錐コイルばねは少ないスペースに収納できるのでばね収納部のコンパクト化が可能となる。さらにこの例では円錐コイルばね５２は板状の当接板部材６２側が太径となっているために、板状の当接板部材６２は薄くてもその中心軸がばね収納室１２ａの中心軸と一致した状態で安定して移動駆動される。 There is a plate-like contact plate member 62 (see FIG. 4C) that is movable in the right and left in the drawing in the spring storage chamber 12a, but a partially enlarged model in which the two-dot chain line portion in FIG. 8A is enlarged. As shown in FIG. 8B, which is a cross-sectional view, the protrusion is inserted into the inside of the spring storage chamber 12a from the outside of the spring storage chamber 12a through the through hole 12a1 provided in the side surface of the spring storage chamber 12a. The edge of the plate-like contact plate member 62 is brought into contact with the locking piece 7 so that the plate-like contact plate member 62 is locked. For this reason, the conical coil spring 62 (arranged so that the large diameter portion is on the injection needle 3 side) disposed on the right side of the plate-like contact plate member 62 in the drawing is held in a compressed state. Since such a conical coil spring can be stored in a small space, the spring storage portion can be made compact. Further, in this example, since the conical coil spring 52 has a large diameter on the plate-like contact plate member 62 side, even if the plate-like contact plate member 62 is thin, its central axis is the central axis of the spring accommodating chamber 12a. Is driven to move stably in a state consistent with.

図８（ｃ）に、組み立て後のキット製剤用注射器を示す。
このような注射器の操作者は、まず、スライド防止Ｃリング６をその切欠き部６ａを利用して除去する。 FIG. 8C shows the syringe for kit preparation after assembly.
An operator of such a syringe first removes the slide prevention C-ring 6 by using the notch 6a.

この例では、ばね圧縮解除手段として、係止片７をばね収納室１２ａ内から除去する係止片除去手段が設けられている。具体的にはスライダ１２ｂと貫通孔１２ａ１とに設けられたカム機構により、係止片除去手段は構成されている。 In this example, a locking piece removing means for removing the locking piece 7 from the spring storage chamber 12a is provided as the spring compression releasing means. Specifically, the locking piece removing means is constituted by a cam mechanism provided in the slider 12b and the through hole 12a1.

操作者が、スライダ１２ｂを注射針方向（図９（ｂ）の矢印方向）にスライドすると、図９（ｂ）の部分拡大モデル図に示されているように、スライダ１２ｂに設けられた回動軸７に軸止されている係止片７は、ばね収納室１２ａの貫通孔１２ａの縁に当接しながら回動駆動されて、その先端がばね収納室１２ａ内部から除去される。その結果、係止片７の先端により係止されていた板状の当接板部材６２は、注射針３方向に移動可能となり、ばね５２により駆動されて摺動弁５に当接（図９（ｄ）参照）したのち、摺動弁５を注射針３側に駆動し、手動弁５により薬液１は注射針３に供給され、その後、注射動作は完了する。 When the operator slides the slider 12b in the direction of the injection needle (the arrow direction in FIG. 9B), as shown in the partially enlarged model diagram of FIG. 9B, the rotation provided on the slider 12b. The locking piece 7 fixed to the shaft 7 is rotationally driven while coming into contact with the edge of the through hole 12a of the spring storage chamber 12a, and its tip is removed from the spring storage chamber 12a. As a result, the plate-like contact plate member 62 locked by the tip of the locking piece 7 can move in the direction of the injection needle 3 and is driven by the spring 52 to contact the sliding valve 5 (FIG. 9). (See (d)), the sliding valve 5 is driven to the injection needle 3 side, the drug solution 1 is supplied to the injection needle 3 by the manual valve 5, and then the injection operation is completed.

次に係止片除去手段として、てこを応用した例について説明する。
図１０は本発明に係るキット製剤用注射器の第５の例を示すモデル図であり、図１０（ａ）は組み立て前の状態を示すモデル断面図である。 Next, an example in which a lever is applied as the locking piece removing means will be described.
FIG. 10 is a model view showing a fifth example of the kit preparation syringe according to the present invention, and FIG. 10 (a) is a model cross-sectional view showing a state before assembly.

薬液室２３は、図７で示した薬液室２３と同じものであるので詳細な説明を省略する。ばね収容室１３の注射針３側の端近くには側面に貫通孔１３ｂが形成されており、貫通孔１３ｂには、操作部材８の係止片部８ｂが挿入されて、操作部材８の係止片部８ｂは、ばね収納室１３内の板状の当接板部材６３の溝部６３ａに嵌合して、ばね収納室１３内のコイルばねにより注射針側に付勢されている板状の当接板部材６３を係止している。 The chemical liquid chamber 23 is the same as the chemical liquid chamber 23 shown in FIG. A through hole 13b is formed near the end of the spring accommodating chamber 13 on the injection needle 3 side, and a locking piece 8b of the operation member 8 is inserted into the through hole 13b. The stop piece 8b is fitted into the groove 63a of the plate-like contact plate member 63 in the spring storage chamber 13 and is urged toward the injection needle by the coil spring in the spring storage chamber 13. The contact plate member 63 is locked.

係止片部８ｂは操作部材８の主部８ｃに設けられており、主部８ｃはばね収納室１３の外側面に接している。主部８ｃには主部８ｃに連続して設けられかつ主部８ｃから離れるに従いばね収納室１３外側面から離間する操作部８ａが設けられている。 The locking piece 8 b is provided on the main portion 8 c of the operation member 8, and the main portion 8 c is in contact with the outer surface of the spring storage chamber 13. The main portion 8c is provided with an operation portion 8a that is provided continuously with the main portion 8c and that is separated from the outer surface of the spring storage chamber 13 as the distance from the main portion 8c increases.

ばね収納室１３の内部、図中右端にはコイルばね５３内に挿入されてばね５３を安定させる凸部１３ｃが設けられている。また、コイルばね５３の他方の端には、板状の当接板部材６３の小径部８３ｄが挿入されているために、コイルばね５３の外径がばね収納室１３の内径よりも小さい場合であってもコイルばね５３は安定して保持される。 A convex portion 13 c that is inserted into the coil spring 53 and stabilizes the spring 53 is provided in the spring housing chamber 13, at the right end in the drawing. In addition, since the small diameter portion 83 d of the plate-like contact plate member 63 is inserted into the other end of the coil spring 53, the outer diameter of the coil spring 53 is smaller than the inner diameter of the spring accommodating chamber 13. Even if it exists, the coil spring 53 is stably hold | maintained.

図１０（ｂ）は、薬液室２３とばね収納室１３とを組み立てて、キット製剤用注射器とした状態を示すモデル断面図である。
操作者は、注注射針３を被注射部位に刺し、次いで操作部材８の操作部８ａを図中矢印に示す方向に操作する。このとき、ばね収納室１３の外側面に接する主部８ｃと操作部８ａとの境界部が、てこの支点として機能して、操作部材８が回動して、操作部材８の係止片部８ｂはばね収納室１３内から除去され、その結果、係止片部８ｂによる係止が解除された板状の当接板部材６３はコイルばね５３により注射針３側に駆動されて、摺動弁３に当接（図１０（ｃ）参照）した後、摺動弁３を駆動して薬液を注射針３に供給する。 FIG. 10B is a model cross-sectional view showing a state in which the drug solution chamber 23 and the spring storage chamber 13 are assembled into a kit preparation syringe.
The operator inserts the injection needle 3 into the injection site, and then operates the operation portion 8a of the operation member 8 in the direction indicated by the arrow in the figure. At this time, the boundary portion between the main portion 8c that contacts the outer side surface of the spring storage chamber 13 and the operation portion 8a functions as a fulcrum of the lever, and the operation member 8 rotates to lock the locking piece portion of the operation member 8. 8b is removed from the inside of the spring accommodating chamber 13, and as a result, the plate-like contact plate member 63 released from the locking by the locking piece portion 8b is driven to the injection needle 3 side by the coil spring 53 and slides. After contacting the valve 3 (see FIG. 10C), the sliding valve 3 is driven to supply the drug solution to the injection needle 3.

上記のキット製剤用注射器は、薬液量が１ｍＬ以下、例えば０．２〜０．５ｍＬとしたときに小型化が可能で、例えば長さが６．５ｃｍ程度、直径１ｃｍ以内のμプレフィルドシリンジとしたとき、スマートな「スタンプ式注射器」となる。さらに、安価で製造可能であるために、使い捨て用途に最適である。なお、充填する薬液はジェネリック医薬品を用いても良い The above-described syringe for kit preparation can be miniaturized when the amount of the drug solution is 1 mL or less, for example, 0.2 to 0.5 mL, for example, a μ prefilled syringe having a length of about 6.5 cm and a diameter of 1 cm or less. Sometimes it becomes a smart “stamped syringe”. Furthermore, since it can be manufactured at low cost, it is most suitable for a disposable use. In addition, generic drug may be used for filling chemicals

また、形状が従来の注射器とは大きく異なり、かつ、スマートなものとすることが可能で、携帯時や一般家庭にあっても物々しい印象を与えずに済み、患者や家族に違和感を与えずに済む。 In addition, the shape is significantly different from conventional syringes, and it can be made smarter, so it does not give a dull impression even when it is carried or in a general household, giving the patient and family a sense of incongruity. You do n’t have to.

操作が簡単であり、注射を打つと云う、強い圧迫感なしに用いることができるので、自分で注射する際の精神的な負担がなく、また、子供に投与する場合にも「注射を打たれる」と云う印象を与えないで済み、好適である。 The operation is simple, and it can be used without a strong feeling of pressure, such as hitting an injection, so there is no mental burden when injecting by yourself. This is preferable because it does not give the impression that

さらに、上記の例では注射針を４本（複数本）備えているために、比較的広範囲に皮下注射でき、免疫付与用途には好適である。また、上記のように注射針は３３ゲージないし３６ゲージのものを用いれば注射時の疼痛は比較的小さい。ここで、このような細い注射針は圧力損失が大きいために、通常の注射器では投与に時間がかかるが、本発明では用いるコイルばねを強力なものとし、かつ、注射針を多数本用いて注射することが可能となり、そのとき、注射動作を比較的早く終了させることができ、投与者及び被投与者の負担を軽減することができる。しかし、本発明は注射針を１本のみ備えたものであっても良い。 Further, in the above example, since four (plural) injection needles are provided, subcutaneous injection can be performed over a relatively wide range, which is suitable for immunization applications. Further, as described above, if an injection needle having a 33 gauge or 36 gauge is used, pain during injection is relatively small. Here, since such a thin injection needle has a large pressure loss, it takes time to administer with a normal syringe. However, in the present invention, the coil spring used is made strong, and injection is performed using a large number of injection needles. At that time, the injection operation can be terminated relatively quickly, and the burden on the user and the recipient can be reduced. However, the present invention may be provided with only one injection needle.

インフルエンザや肝炎等のワクチン、あるいは、インスリン等の投与は勿論、ビタミン剤投与等にも使用でき、また、美容整形、ペット用途などにも広く応用できる。 It can be used not only for vaccines such as influenza and hepatitis, or for administration of vitamins, but also for vitamin preparations, etc., and can also be widely applied to cosmetic surgery and pet applications.

以上、本発明について、好ましい実施形態を挙げて説明したが、本発明のキット製剤用注射器及びキット製剤は、上記実施形態の構成に限定されるものではない。 As mentioned above, although this invention was demonstrated and mentioned with preferable embodiment, the syringe for kit preparations and kit preparation of this invention are not limited to the structure of the said embodiment.

当業者は、従来公知の知見に従い、本発明のキット製剤用注射器及びキット製剤を適宜改変することができる。このような改変によってもなお本発明のキット製剤用注射器及びキット製剤の構成を具備する限り、もちろん、本発明の範疇に含まれるものである。 A person skilled in the art can appropriately modify the syringe for a kit preparation and the kit preparation of the present invention according to conventionally known knowledge. Of course, such modifications are still included in the scope of the present invention as long as they have the configuration of the kit preparation syringe and kit preparation of the present invention.

１薬液
２キャップ
３注射針
４薬液パック
４ａ鍔部
５摺動弁
６スライド防止Ｃリング
７係止片
８操作部材
８ａ操作部
８ｂ係止片部
８ｃ主部
１０、１１、１２ａばね収納室
１１ｂ凸部
１２ａ１貫通孔
１２ｂスライダ
１３ｂ貫通孔
２０、２１、２２薬液室
２０ｂ隔膜
２２ａ注射針側部材
２２ｂ側面部材
２２ａ３凸部
４０、４１操作部材
４０ｃ突出部
５０、５１コイルばね
５０ｂ太径部
５２円錐コイルばね
６０、６１摺動部
６２板状の当接板部材 DESCRIPTION OF SYMBOLS 1 Chemical solution 2 Cap 3 Injection needle 4 Chemical solution pack 4a collar part 5 Sliding valve 6 Slide prevention C ring 7 Locking piece 8 Operation member 8a Operation part 8b Locking piece part 8c Main part 10, 11, 12a Spring storage chamber 11b Convex Part 12a1 Through-hole 12b Slider 13b Through-hole 20, 21, 22 Chemical solution chamber 20b Diaphragm 22a Injection needle side member 22b Side member 22a3 Protrusion part 40, 41 Operation member 40c Projection part 50, 51 Coil spring 50b Large diameter part 52 Conical coil spring 60, 61 Sliding part 62 Plate-like contact plate member

Claims

A chemical chamber that holds chemicals inside,
An injection needle having a base communicating with the chemical chamber, at one end of the chemical chamber,
A cylindrical spring storage chamber in which a coil spring is stored inside the other end side of the chemical chamber, and
A spring compression release means for holding the coil spring in a compressed state and releasing the compression of the coil spring during an injection operation and supplying the drug solution in the drug solution chamber to the injection needle by the coil spring;
A syringe for kit preparations, comprising:

The syringe for kit preparation according to claim 1, wherein the spring storage chamber is provided so as to be separable from the drug solution chamber.

A large diameter portion provided in the vicinity of the tip of the coil spring on the injection needle side is locked by a convex portion provided on the inner surface of the spring storage chamber, and the coil spring is held in a compressed state. As the spring compression release means, the distal end side portion of the coil spring is moved to the injection needle side to reduce the diameter of the large diameter portion and release the locking of the large diameter portion. The syringe for kit preparation according to claim 1 or 2, wherein a coil spring tip portion operating member is provided in the spring storage chamber.

A plate-like contact plate member whose edge is brought into contact with and locked by a convex portion provided on the inner surface of the spring storage chamber is perpendicular to the distal end of the coil spring on the injection needle side and perpendicular to the extending direction of the coil spring. Arranged and held in a compressed state by the coil spring;
As the spring compression release means, a pressure application operation part that deforms the plate-like contact plate part by applying a pressure in the injection needle direction to the coil spring to release the locking is provided in the spring storage chamber. The syringe for kit preparation according to claim 1 or 2, wherein the syringe is provided.

A plate-like abutting plate member whose edge is abutted and locked to a convex portion inserted into the inside of the spring accommodating chamber from the outside of the spring accommodating chamber through a through hole provided in a side surface of the spring accommodating chamber. Is disposed at the tip of the coil spring on the injection needle side and perpendicular to the direction in which the coil spring extends, and the coil spring is held in a compressed state,
The syringe for kit preparation according to claim 1 or 2, wherein a locking piece removing means for removing the locking piece from the spring storage chamber is provided as the spring compression releasing means.

A slider part that slides back and forth in the direction of the injection needle is provided on the outer surface of the spring storage chamber,
The locking piece removing means drives the locking piece when the slider portion is slid in the injection needle direction by a cam mechanism provided in the slider portion and the through hole. 6. The syringe for kit preparation according to claim 5, wherein the syringe is a means for removing from the kit.

The locking piece removing means has the locking piece and is in contact with the outer surface of the spring accommodating chamber, and is provided continuously with the main portion and is separated from the outer surface as the distance from the main portion increases. The kit preparation syringe according to claim 5, further comprising an operation unit that performs the operation.

A diaphragm for destroying the diaphragm at the tip of the coil spring on the syringe needle side has an easily destructible diaphragm for watertightly sealing the spring storage chamber side of the drug solution chamber on the spring storage chamber side of the drug solution chamber. 8. The apparatus according to claim 1, further comprising: a destruction means; and a sliding portion that is driven by the coil spring during an injection operation to supply the chemical liquid to the injection needle while contacting the side surface of the chemical liquid chamber. A syringe for a kit preparation according to claim 1.

A sliding valve that seals the chemical solution chamber on the side of the spring storage chamber and supplies the chemical solution to the injection needle while being in contact with the side surface of the chemical solution chamber while being driven by the coil spring during an injection operation. The syringe for kit preparation according to any one of claims 1 to 7, wherein the syringe is for kit preparation.

It has a syringe for kit preparation according to any one of claims 1 to 7,
A chemical pack made of a film made of a soft resin material filled with a chemical solution in a watertight manner is stored in the chemical solution chamber, and at least one of the films when a pressure is applied to the chemical pack by the coil spring during an injection operation. A kit preparation comprising a film cutting part for cutting the part on the inner surface of the chemical solution chamber.

The medicinal solution pack has a collar part protruding in a direction perpendicular to the injection needle direction on the entire circumference, the medicinal solution chamber is constituted by two members before and after the collar part, and the two members are combined. When the chemical chamber is formed, the collar is sandwiched between the two members, and the front and rear of the collar are watertightly divided, and the injection needle side member of the two members is It has the said film cutting part, The kit formulation of Claim 10 characterized by the above-mentioned.

A kit preparation comprising the syringe for a kit preparation according to any one of claims 1 to 9.

The kit preparation according to any one of claims 10 to 12, further comprising a detachable cap that protects the tip of the injection needle in a watertight manner.

The kit preparation according to any one of claims 11 to 13, comprising a plurality of the injection needles.

The kit preparation according to any one of claims 11 to 14, which is a kit preparation for influenza virus subcutaneous injection.