JP2014033851A - Electrode for nerve - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an electrode for a nerve, which has durability sufficient for the electrode for the nerve, which can have strength which enables introduction even into a deep region in the brain, which can be easily worked into a shape capable of being introduced even into the deep region in the brain, and which enables accurate measurement of a faint electric signal.SOLUTION: An electrode for a nerve is used to measure a faint electric signal flowing through nerve cells in a living organism. The electrode for the nerve includes a nonconductive needle-shaped electrode body, and an electrode for measuring the faint electric signal flowing through the nerve cells.

Description

  The present invention relates to a nerve electrode that is mainly used by being inserted into the brain in order to measure weak electrical signals flowing in nerve cells in a living body, for example, to elucidate and treat brain functions and the like.

Conventionally, in order to elucidate brain functions, electrodes have been inserted into the brain, and weak electrical signals (cell action potentials) flowing through brain neurons have been measured.
As such an electrode used by being inserted into a living body such as the inside of a brain (hereinafter referred to as “neural electrode”), for example, a metal needle-like single electrode whose surface is insulated with glass or the like, A multi-point electrode composed of a plurality of silicon needles is used.

FIG. 21 is a schematic configuration diagram for explaining a configuration of a conventional nerve electrode. FIG. 21 (a) is a front view of the nerve electrode, and FIG. 21 (b) is a side view of the nerve electrode. 22 is a schematic configuration diagram for explaining the configuration of the nerve electrode in FIG. 21, FIG. 22 (a) is an enlarged front view, and FIG. 22 (b) is an XX cross-sectional view.
As shown in FIGS. 21 and 22, the conventional nerve electrode 100 has an electrode body 102, a base 104, and a plurality of electrodes 106.

  The electrode main body 102 is made of, for example, a metal such as tungsten, and the tip end portion 102a of the electrode main body 102 is processed into a taper shape and has a needle shape. The electrode body 102 is insulated except for its tip 102b.

  The base 104 is made of glass, silicon, a polymer material, or the like. The base 104 is formed in a square bar shape, is fitted in the groove 102d of the electrode body 102, and is fixed with an adhesive or the like.

  The plurality of electrodes 106 are provided at predetermined intervals along the length direction of the electrode main body 102 from the tip 102b side of the electrode main body 102 so as to be exposed on the surface of the base 104. The wiring 106 a embedded in the wiring 104 is connected to a plurality of terminals 108 provided on the terminal 102 c side of the electrode body 102.

  The nerve electrode 100 configured in this way is used, for example, by being inserted into the inside of the brain, and the action potential of brain cells can be measured at multiple points by the tip 102b of the electrode body 102 and each electrode 106.

JP 2011-36360 A

  However, in the nerve electrode 100 in which the electrode body 102 is formed of metal in this way, the capacitance between each electrode 106 and the electrode body 102, the capacitance between the wiring 106a and the electrode body 102, and the like. Depending on the influence, the action potential of a cell, which is a weak electric signal, may not be measured accurately.

  In addition, there have been non-metallic materials that have been used as electrodes, but all of them are thin-film electrodes that have low strength and are difficult to introduce into the deep brain.

  In view of such a current situation, the present invention has sufficient durability as a nerve electrode, can have a strength that can be introduced into the deep brain, and is processed into a shape that can be introduced into the deep brain. It is also an object of the present invention to provide a nerve electrode that can easily measure a weak electric signal accurately.

The present invention has been invented in order to solve the above-described problems in the prior art, and the nerve electrode of the present invention is used for nerves for measuring weak electric signals flowing in nerve cells in a living body. An electrode,
A non-conductive, needle-shaped electrode body;
An electrode for measuring a weak electrical signal flowing through the nerve cell;
It is characterized by providing.

Moreover, in the electrode for nerves of this invention, it is preferable that the material which forms the said electrode main body is a composite material comprised from a resin base material and a reinforcement base material.
Moreover, in the electrode for nerves of this invention, it is preferable that the Young's modulus of the said reinforcement | strengthening base material is 10 GPa or more.

In the nerve electrode according to the present invention, the electrodes may be a plurality of electrodes provided at a predetermined interval.
Moreover, in the electrode for nerves of this invention, you may comprise so that the said electrode main body may have the base part in which the said electrode was provided along the length direction of this electrode main body.

In the nerve electrode of the present invention, a plurality of the base portions may be provided in the electrode body.
Further, in the nerve electrode of the present invention, the electrode body includes a groove extending along the length direction,
A base portion provided with the electrode may be fitted into the groove and fixed.
Moreover, in the electrode for nerves of this invention, the said electrode may be provided in the surface of the said electrode main body.

In the nerve electrode of the present invention, the needle-like tip of the electrode body may be formed separately from the electrode body.
In the nerve electrode according to the present invention, the electrode body may be provided with a channel hole along the length direction of the electrode body.

  In the nerve electrode of the present invention, the electrode body may have a light guide formed along the length direction of the electrode body.

  According to the present invention, since the electrode body of the nerve electrode is formed of a non-conductive material, no electrostatic capacitance is generated between the electrode and the electrode body or between the wiring and the electrode body, and the weakness is weak. It is possible to accurately measure the action potential of a cell, which is a simple electrical signal.

  In addition, according to the present invention, the electrode body of the nerve electrode is formed of a composite material or a single material having a Young's modulus of 10 GPa or more of the reinforced base material, so that it has sufficient durability as a nerve electrode. It can be made strong enough to be introduced into the deep brain, can be easily processed into a shape that can be introduced into the deep brain, and manufacturing costs can be reduced even in mass production.

FIG. 1 is a schematic configuration diagram for explaining the configuration of a nerve electrode according to the present invention. FIG. 1 (a) is a side view of the nerve electrode, and FIG. 1 (b) is a plan view of the nerve electrode. . 2 is a cross-sectional view of the nerve electrode of FIG. 1, FIG. 2 (a) is an Ax-Ax cross-sectional view, and FIG. 2 (b) is an Ay-Ay cross-sectional view. 3A and 3B are schematic configuration diagrams for explaining the configuration of another embodiment of the nerve electrode of the present invention, FIG. 3A is a side view of the nerve electrode, and FIG. 3B is a nerve electrode. FIG. 4 is a cross-sectional view of the nerve electrode of FIG. 3, FIG. 4 (a) is a Bx-Bx cross-sectional view, and FIG. 4 (b) is a By-By cross-sectional view. FIG. 5 is a schematic configuration diagram for explaining a modified example of the configuration of the nerve electrode of the present invention. FIG. 5 (a) is a side view of the nerve electrode, and FIG. 5 (b) is a plan view of the nerve electrode. FIG. 6 is a cross-sectional view of the nerve electrode of FIG. 5, FIG. 6 (a) is a Cx-Cx cross-sectional view, and FIG. 6 (b) is a Cy-Cy cross-sectional view. FIG. 7 is a schematic configuration diagram for explaining another modified example of the configuration of the nerve electrode of the present invention. FIG. 7 (a) is a side view of the nerve electrode, and FIG. 7 (b) is a nerve electrode. FIG. 8 is a cross-sectional view of the nerve electrode of FIG. 7, FIG. 8 (a) is a Dx-Dx cross-sectional view, and FIG. 8 (b) is a Dy-Dy cross-sectional view. FIG. 9 is a schematic configuration diagram for explaining the configuration of still another embodiment of the nerve electrode according to the present invention. FIG. 9A is a side view of the nerve electrode, and FIG. It is a top view of an electrode. 10 is a cross-sectional view of the nerve electrode of FIG. 9, FIG. 10 (a) is an Ex-Ex cross-sectional view, and FIG. 10 (b) is an Ey-Ey cross-sectional view. FIG. 11 is a schematic configuration diagram for explaining the configuration of still another embodiment of the nerve electrode according to the present invention. FIG. 11A is a side view of the nerve electrode, and FIG. It is a top view of an electrode. 12 is a cross-sectional view of the nerve electrode of FIG. 11, FIG. 12 (a) is an Fx-Fx cross-sectional view, and FIG. 12 (b) is an Fy-Fy cross-sectional view. FIG. 13 is a schematic configuration diagram for explaining the configuration of still another embodiment of the nerve electrode according to the present invention. FIG. 13A is a side view of the nerve electrode, and FIG. It is a top view of an electrode. 14 is a cross-sectional view of the nerve electrode of FIG. 13, FIG. 14A is a Gx-Gx cross-sectional view, and FIG. 14B is a Gy-Gy cross-sectional view. 15A and 15B are schematic configuration diagrams for explaining the configuration of still another embodiment of the nerve electrode of the present invention. FIG. 15A is a side view of the nerve electrode, and FIG. It is a top view of an electrode. 16 is a cross-sectional view of the nerve electrode of FIG. 15, FIG. 16 (a) is a Hx-Hx cross-sectional view, and FIG. 16 (b) is a Hy-Hy cross-sectional view. FIG. 17 is a schematic configuration diagram for explaining the configuration of still another embodiment of the nerve electrode of the present invention. FIG. 17 (a) is a side view of the nerve electrode, and FIG. It is a top view of an electrode. 18 is a cross-sectional view of the nerve electrode of FIG. 17, in which FIG. 18 (a) is an Ix-Ix cross-sectional view, and FIG. 18 (b) is an Iy-Iy cross-sectional view. FIG. 19 is a schematic configuration diagram for explaining a modified example of the configuration of the nerve electrode of the present invention. FIG. 19 (a) is a side view of the nerve electrode, and FIG. 19 (b) is a plan view of the nerve electrode. FIG. 20 is a cross-sectional view of the nerve electrode of FIG. 19, FIG. 20 (a) is a Jx-Jx cross-sectional view, and FIG. 20 (b) is a Jy-Jy cross-sectional view. FIG. 21 is a schematic configuration diagram for explaining a configuration of a conventional nerve electrode. FIG. 21 (a) is a front view of the nerve electrode, and FIG. 21 (b) is a side view of the nerve electrode. 22 is a schematic configuration diagram for explaining the configuration of the nerve electrode of FIG. 21, FIG. 22 (a) is an enlarged front view, and FIG. 22 (b) is an XX cross-sectional view.

Hereinafter, embodiments (examples) of the present invention will be described in more detail based on the drawings.
FIG. 1 is a schematic configuration diagram for explaining the configuration of a nerve electrode according to the present invention. FIG. 1 (a) is a side view of the nerve electrode, and FIG. 1 (b) is a plan view of the nerve electrode. . 2 is a cross-sectional view of the nerve electrode of FIG. 1, FIG. 2 (a) is an Ax-Ax cross-sectional view, and FIG. 2 (b) is an Ay-Ay cross-sectional view.

As shown in FIGS. 1 and 2, the nerve electrode 10 according to the present embodiment includes an electrode body 12, a base portion 14, and a plurality of electrodes 16.
The electrode body 12 is made of, for example, a resin base material such as a photocurable resin such as an ultraviolet curable resin, a thermosetting resin such as an epoxy resin, or a thermoplastic resin such as a polycarbonate resin, and a glass short fiber or a long glass fiber, for example. It is formed of a non-conductive composite material composed of a reinforced substrate.

  In order to secure the strength of the electrode body 12, it is preferable to use a reinforced base material having a Young's modulus of 10 GPa or more. Further, the electrode body 12 may be formed of a non-conductive single material if the nerve electrode 10 can secure sufficient strength to be inserted into, for example, the cerebral buffy coat or deep brain. I do not care.

  Examples of the material forming the electrode body 12 include glass fiber reinforced plastic (GFRP), long glass fiber reinforced plastic (GMT), polyethylene fiber reinforced plastic (FRP), carbon fiber reinforced plastic (CFRP), and boron fiber. Examples thereof include reinforced plastic (BFRP), aramid fiber reinforced plastic (AFRP), Zylon reinforced plastic (ZFRP), liquid crystal polymer, and fine ceramics.

  Further, the tip end portion 12a of the electrode body 12 is processed into a taper shape and has a needle shape. Further, a groove 12 d extending along the length direction of the electrode body 12 is provided on the upper surface of the electrode body 12.

Since the base portion 14 is fitted and fixed in the groove 12 d, the groove 12 d is provided in a shape that engages with the base portion 14.
The base portion 14 is formed of, for example, glass, silicon, a polymer material, or the like. In the present embodiment, the base portion 14 is formed in a square bar shape, is fitted into the groove 12d of the electrode body 12, and is fixed by, for example, an adhesive.

  The plurality of electrodes 16 are provided at predetermined intervals along the length direction of the electrode body 12 from the tip 12b side of the electrode body 12 so as to be exposed on the surface of the base portion 14. Each electrode 16 is connected to a plurality of terminals 18 provided on the end 12c side of the electrode main body 12 by wiring formed on the base portion 14 using a microfabrication technique. In addition, the wiring can also be coated with an insulation to improve signal accuracy.

  Note that the number and positions of the electrodes 16 are not particularly limited, and can be provided in the necessary number and positions as the nerve electrodes 10. For example, a single electrode 16 may be provided on the base 14. A plurality of electrodes 16 may be provided on the base 14 in a staggered manner.

  The plurality of terminals 18 are connected to a display unit such as a monitor (not shown) and an electrical signal acquisition unit, and display an electrical signal such as a cell action potential measured by the plurality of electrodes 16 on the display unit. The action potential of the cell can be acquired by the acquisition means.

Further, by connecting the plurality of terminals 18 to the electric signal input means, it is possible to apply electrical stimulation to the cells from the plurality of electrodes 16.
The nerve electrode 10 of this embodiment configured as described above is used, for example, by being stabbed inside the brain, and the action potentials of brain cells can be measured at multiple points by the plurality of electrodes 16 of the electrode body 12. .

  Since the electrode body 12 is formed of a composite material composed of a resin base material and a reinforced base material, the nerve electrode 10 is sufficient to be inserted into, for example, the brain buffy coat or deep brain. It has a strong strength.

  In addition, since the electrode body 12 is formed of a non-conductive composite material, no capacitance is generated between the plurality of electrodes 16 and the electrode body 12 or between the wiring 16a and the electrode body 12, Even the action potential of a cell, which is a weak electric signal, can be accurately measured.

  3A and 3B are schematic configuration diagrams for explaining the configuration of another embodiment of the nerve electrode of the present invention, FIG. 3A is a side view of the nerve electrode, and FIG. 3B is a nerve electrode. FIG. 4 is a cross-sectional view of the nerve electrode of FIG. 3, FIG. 4 (a) is a Bx-Bx cross-sectional view, and FIG. 4 (b) is a By-By cross-sectional view.

  The nerve electrode 10 of this embodiment has basically the same configuration as that of the nerve electrode 10 shown in FIGS. 1 and 2, and the same reference numerals are given to the same constituent members, and the detailed description thereof is omitted. Description is omitted.

  In the nerve electrode 10 shown in FIGS. 3 and 4, the distal end portion 12a is processed into a conical shape and has a needle shape. In the nerve electrode 10 of this embodiment, the distal end portion 12a is formed separately from the electrode main body 12, but the distal end portion 12a and the electrode main body 12 may be integrally formed.

  When the distal end portion 12a is configured separately from the electrode body 12, the distal end portion 12a may be formed of the same material as the electrode body 12, and is different from the electrode body 12 such as glass, ceramics, or metal. You may form with a material.

  Thus, in the present invention, the shape and material of the distal end portion 12a of the nerve electrode 10 are not particularly limited. For example, as shown in FIGS. 5 and 6, the electrode body 12 and the distal end portion 12a are related. As shown in FIGS. 7 and 8, the connecting portion 12f having the tapered surface 12e and the tip portion 12a may be configured separately.

  As shown in FIGS. 7 and 8, when the connection portion 12f is provided, the connection portion 12f may be formed of the same material as that of the electrode body 12 as with the tip portion 12a. The electrode body 12 may be formed of a different material.

  FIG. 9 is a schematic configuration diagram for explaining the configuration of still another embodiment of the nerve electrode according to the present invention. FIG. 9A is a side view of the nerve electrode, and FIG. It is a top view of an electrode. 10 is a cross-sectional view of the nerve electrode of FIG. 9, FIG. 10 (a) is an Ex-Ex cross-sectional view, and FIG. 10 (b) is an Ey-Ey cross-sectional view.

  The nerve electrode 10 of this embodiment has basically the same configuration as that of the nerve electrode 10 shown in FIGS. 1 and 2, and the same reference numerals are given to the same constituent members, and the detailed description thereof is omitted. Description is omitted.

  In the nerve electrode 10 shown in FIGS. 9 and 10, a flow path hole 20 is provided along the length direction of the electrode body 12. By providing such a channel hole 20, a drug or the like can be injected into the channel hole 20 in a state where the nerve electrode 10 is inserted into, for example, the inside of the brain. Can be given.

  In this state, by measuring the cell action potential at multiple points using the plurality of electrodes 16, it is possible to easily and accurately measure the reaction of the cell due to stimulation with a drug or the like.

  FIG. 11 is a schematic configuration diagram for explaining the configuration of still another embodiment of the nerve electrode according to the present invention. FIG. 11A is a side view of the nerve electrode, and FIG. It is a top view of an electrode. 12 is a cross-sectional view of the nerve electrode of FIG. 11, FIG. 12 (a) is a Fx-Fx cross-sectional view, and FIG. 12 (b) is a Fy-Fy cross-sectional view.

  The nerve electrode 10 of this embodiment has basically the same configuration as that of the nerve electrode 10 shown in FIGS. 1 and 2, and the same reference numerals are given to the same constituent members, and the detailed description thereof is omitted. Description is omitted.

  In the nerve electrode 10 shown in FIGS. 11 and 12, a light guide hole 22 is formed along the length direction of the electrode body 12 from the end 12c side of the electrode body 12 to the vicinity of the tip 12a. An optical fiber 23 is inserted into the hole 22 to form a light guide path 24.

  By inserting the light guide path 24 in this manner, light stimulation can be given to cells using the light guide path 24 in a state where the nerve electrode 10 is inserted into the brain, for example. .

  In this state, by measuring the cell action potential at multiple points using the plurality of electrodes 16, it is possible to easily and accurately measure the cell reaction caused by light stimulation. In addition, since the electrode body 12 is made of a non-conductive material, noise due to the photoelectric effect generated when light is irradiated on a metal or the like is not generated, and the cell reaction due to light stimulation is accurately measured. can do.

  In this embodiment, the optical fiber 23 is inserted into the light guide hole 22. However, if the light guide hole 22 is formed with the light guide path 24 having an optical waveguide structure, the nerve electrode can be inserted without inserting the optical fiber 23 or the like. Light can be transmitted to 10 tip portions 12a, and stimulation by light can be given to cells.

  Further, in the case where light is emitted in the vicinity of the distal end portion 12a of the nerve electrode 10 as described above, at least the distal end portion 12a of the electrode body 12 is preferably formed of a light-transmitting material.

  In the present embodiment, the light is emitted near the distal end portion 12a of the nerve electrode 10. However, the present invention is not limited to this, and the light emission position is between the distal end 12b side and the distal end 12c side of the electrode body 12. It can be set at any position.

  FIG. 13 is a schematic configuration diagram for explaining the configuration of still another embodiment of the nerve electrode according to the present invention. FIG. 13A is a side view of the nerve electrode, and FIG. It is a top view of an electrode. 14 is a cross-sectional view of the nerve electrode of FIG. 13, FIG. 14 (a) is a Gx-Gx cross-sectional view, and FIG. 14 (b) is a Gy-Gy cross-sectional view.

  The nerve electrode 10 of this embodiment has basically the same configuration as that of the nerve electrode 10 shown in FIGS. 1 and 2, and the same reference numerals are given to the same constituent members, and the detailed description thereof is omitted. Description is omitted.

  The neural electrode 10 shown in FIGS. 13 and 14 includes base portions 14 on both upper and lower sides in FIG. As described above, the electrode body 12 includes a plurality of base portions 14 each having a plurality of electrodes 16, whereby the number of electrodes 16 that can be measured with one nerve electrode 10 can be further increased.

  In addition, although it has set as the structure provided with the two base parts 14 in the electrode 10 for nerves shown in FIG.13, 14, it is not specifically limited, The some base part 14 can be provided.

  15A and 15B are schematic configuration diagrams for explaining the configuration of still another embodiment of the nerve electrode of the present invention. FIG. 15A is a side view of the nerve electrode, and FIG. It is a top view of an electrode. 16 is a cross-sectional view of the nerve electrode of FIG. 15, FIG. 16 (a) is a Hx-Hx cross-sectional view, and FIG. 16 (b) is a Hy-Hy cross-sectional view.

  The nerve electrode 10 of this embodiment has basically the same configuration as that of the nerve electrode 10 shown in FIGS. 1 and 2, and the same reference numerals are given to the same constituent members, and the detailed description thereof is omitted. Description is omitted.

  In the nerve electrode 10 shown in FIGS. 1 to 14, a groove 12 d extending along the length direction of the electrode body 12 is provided, and the base portion 14 is fitted and fixed in the groove 12 d. The nerve electrode 10 is bonded and fixed in a state where the base portion 14 is placed on the upper surface of the electrode body 12.

  Thus, even if the groove 12d is not provided, the base portion 14 having the plurality of electrodes 16 only needs to be bonded and fixed to the upper surface of the electrode body 12, so that the manufacturing process is simplified and the manufacturing cost can be reduced.

  FIG. 17 is a schematic configuration diagram for explaining the configuration of still another embodiment of the nerve electrode of the present invention. FIG. 17 (a) is a side view of the nerve electrode, and FIG. It is a top view of an electrode. 18 is a cross-sectional view of the nerve electrode of FIG. 17, FIG. 18 (a) is an Ix-Ix cross-sectional view, and FIG. 18 (b) is an Iy-Iy cross-sectional view.

  The nerve electrode 10 of this embodiment has basically the same configuration as that of the nerve electrode 10 shown in FIGS. 1 and 2, and the same reference numerals are given to the same constituent members, and the detailed description thereof is omitted. Description is omitted.

In the nerve electrode 10 shown in FIGS. 17 and 18, the plurality of electrodes 16 are not provided on the base portion 14 but are provided directly on the electrode body 12.
That is, a plurality of electrodes 16, wirings 16 a, and a plurality of terminals 18 are provided on the electrode body 12 formed of a non-conductive composite material composed of a resin base material and a reinforced base material.

  In the embodiment shown in FIGS. 1 to 16, the plurality of electrodes 16 and the plurality of terminals 18 are connected to each other by wiring formed on the base portion 14 by using microfabrication technology. As described above, the wiring 16 a connecting the plurality of electrodes 16 and the plurality of terminals 18 may be embedded in the electrode body 12.

  Thus, even if the base 14 is not provided, the composite material itself that forms the electrode body 12 has sufficient strength. For example, the composite material may be broken or cracked even when inserted into the cerebral buffy coat or deep brain. Such a problem does not occur.

  Further, by providing a plurality of electrodes 16, wirings 16 a, and a plurality of terminals 18 directly on the electrode body 12 formed of a non-conductive composite material without providing the base portion 14, the nerve electrode 10 can be manufactured. The process becomes simple, and the manufacturing cost can be reduced even in mass production.

  In this embodiment, the electrode body 12 having a U-shaped Iy-Iy cross-section is used. For example, as shown in FIGS. 19 and 20, the electrode body 12 having a circular Jy-Jy cross-section is used. It can also be used.

  The preferred embodiment of the present invention has been described above, but the present invention is not limited to this. For example, the electrode body 12 is configured to be provided with both the flow path hole 20 and the light guide hole 22. In addition, various changes can be made without departing from the object of the present invention, such as providing an electrode body 12 or a base 14 with a sensor that reacts with a living body such as a brain cell such as an enzyme-type biosensor. Is possible.

DESCRIPTION OF SYMBOLS 10 Nerve electrode 12 Electrode main body 12a Tip part 12b Tip 12c Terminal 12d Groove 12e Tapered surface 12f Connection part 14 Base 16 Electrode 16a Wiring 18 Terminal 20 Channel hole 22 Light guide hole 23 Optical fiber 24 Light guide path 100 Neural electrode 102 Electrode body 102a tip 102b tip 102c end 102d groove 104 base 106 electrode 106a wiring 108 terminal

Claims (11)

A nerve electrode for measuring a weak electrical signal flowing in a nerve cell in a living body,
A non-conductive, needle-shaped electrode body;
An electrode for measuring a weak electrical signal flowing through the nerve cell;
A nerve electrode comprising:   2. The nerve electrode according to claim 1, wherein the material forming the electrode body is a composite material composed of a resin base material and a reinforced base material.   The nerve electrode according to claim 2, wherein Young's modulus of the reinforced substrate is 10 GPa or more.   The nerve electrode according to any one of claims 1 to 3, wherein the electrodes are a plurality of electrodes provided at predetermined intervals.   The nerve electrode according to any one of claims 1 to 4, wherein the electrode body has a base portion on which the electrode is provided along a length direction of the electrode body.   The nerve electrode according to claim 5, wherein a plurality of the base portions are provided in the electrode main body. The electrode body includes a groove extending along a length direction;
The nerve electrode according to claim 5 or 6, wherein a base portion on which the electrode is provided is fitted and fixed in the groove.   The electrode for nerve according to any one of claims 1 to 4, wherein the electrode is provided on a surface of the electrode body.   The nerve electrode according to any one of claims 1 to 8, wherein a needle-like tip of the electrode body is formed separately from the electrode body.   The nerve electrode according to any one of claims 1 to 9, wherein the electrode body is provided with a channel hole along a length direction of the electrode body.   11. The nerve electrode according to claim 1, wherein the electrode body has a light guide formed along a length direction of the electrode body.

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