JP2013536872A - 高用量ブプレノルフィン組成物及び使用方法 - Google Patents
高用量ブプレノルフィン組成物及び使用方法 Download PDFInfo
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- JP2013536872A JP2013536872A JP2013527354A JP2013527354A JP2013536872A JP 2013536872 A JP2013536872 A JP 2013536872A JP 2013527354 A JP2013527354 A JP 2013527354A JP 2013527354 A JP2013527354 A JP 2013527354A JP 2013536872 A JP2013536872 A JP 2013536872A
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- buprenorphine
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Abstract
Description
以下の実施例では、Buprenex(登録商標)を使用した。22g針の付いた注射器に適切容量のブプレノルフィンまたは対照を充填し、肩甲骨間の頸の付け根に皮下注射により投与した。
通常用量よりも高量で投与した非徐放性ブプレノルフィン注射液の鎮痛期間についての有効性を評価するために研究を実施した。非徐放性高用量ブプレノルフィン注射液の有効性を評価するために熱閾値研究及び手術研究を実施した。8つの処置群を評価した5つの研究を実施した。
上記結果及び哺乳動物における術後疼痛に対する高用量ブプレノルフィンの意図する使用に基づいて、外科的研究を実施した。研究対象のネコは卵巣子宮切除術または整形外科(爪切除術)処置を受け、術後疼痛コントロールの有効性を調べるためにモニターした。これらの研究の目的は、外科処置後少なくとも24時間鎮痛を与える単回高用量の非徐放性ブプレノルフィン製剤の能力を評価すること、及び24時間あけて製剤を3回投与して72時間にわたって術後疼痛をコントロールするブプレノルフィンの能力を評価することであった。
高用量非徐放性ブプレノルフィン製剤の安全性を調べるために以下のブプレノルフィン製剤を各種投与量で試験した。
Claims (25)
- 処置を要する哺乳動物に対して単回高用量のブプレノルフィンを非経口投与するステップを含む哺乳動物において長期鎮痛効果を生じさせる方法であって、前記用量は前記哺乳動物に対して十分な鎮痛を少なくとも12時間与える、前記方法。
- 哺乳動物はイヌ科の動物及びネコ科の動物からなる請求項1に記載の方法。
- 哺乳動物はネコ科の動物からなる請求項1に記載の方法。
- 非経口投与は皮下投与、筋肉内投与、静脈内投与、動脈内投与、大脳内投与、皮内投与または鞘内投与からなる請求項1に記載の方法。
- ブプレノルフィンを非徐放性剤形として投与する請求項1に記載の方法。
- 非経口投与は皮下投与または筋肉内投与からなる請求項1に記載の方法。
- 高用量のブプレノルフィンは総哺乳動物体重1kgにつき約0.04mgのブプレノルフィン〜総哺乳動物体重1kgにつき約2mgのブプレノルフィンからなる請求項1に記載の方法。
- 高用量ブプレノルフィンは総哺乳動物体重1kgにつき約0.06mgのブプレノルフィン〜総哺乳動物体重1kgにつき約1.0mgのブプレノルフィンからなる請求項1に記載の方法。
- 高用量ブプレノルフィンは総哺乳動物体重1kgにつき約0.1mgのブプレノルフィン〜総哺乳動物体重1kgにつき約0.5mgのブプレノルフィンからなる請求項1に記載の方法。
- 高用量のブプレノルフィンは総哺乳動物体重1kgにつき約0.12mgのブプレノルフィン〜総哺乳動物体重1kgにつき約0.3mgのブプレノルフィンからなる請求項1に記載の方法。
- 高用量ブプレノルフィンは哺乳動物に対して十分な鎮痛を12時間、24時間及び48時間からなる群から選択される期間与える請求項1に記載の方法。
- 単回高用量のブプレノルフィンまたはその医薬として許容できる塩を非経口投与するステップを含むネコ科の動物において長期鎮痛効果を生じさせる方法であって、前記用量はネコ科の動物に対して十分な鎮痛を約12時間〜約48時間与える、前記方法。
- ブプレノルフィンを非徐放性剤形として投与する請求項12に記載の方法。
- 非経口投与は皮下投与または筋肉内投与からなる請求項12に記載の方法。
- 高用量のブプレノルフィンは総哺乳動物体重1kgにつき約0.04mgのブプレノルフィン〜総哺乳動物体重1kgにつき約2mgのブプレノルフィンからなる請求項12に記載の方法。
- 高用量のブプレノルフィンは総哺乳動物体重1kgにつき約0.06mgのブプレノルフィン〜総哺乳動物体重1kgにつき約1.0mgのブプレノルフィンからなる請求項12に記載の方法。
- 高用量のブプレノルフィンは総哺乳動物体重1kgにつき約0.1mgのブプレノルフィン〜総哺乳動物体重1kgにつき約0.5mgのブプレノルフィンからなる請求項12に記載の方法。
- 高用量のブプレノルフィンは総哺乳動物体重1kgにつき約0.12mgのブプレノルフィン〜総哺乳動物体重1kgにつき約0.3mgのブプレノルフィンからなる請求項12に記載の方法。
- ネコ科の動物に対してネコ科の動物体重1kgにつき約0.12mgのブプレノルフィン〜ネコ科の動物体重1kgにつき約0.3mgのブプレノルフィンの範囲の単回用量のブプレノルフィンを皮下投与することを含むネコ科の動物において長期鎮痛効果を生じさせる方法であって、前記用量はブプレノルフィンを含有する非徐放性剤形の形態で与え、前記用量はネコ科の動物に対して十分な鎮痛を約18時間〜約30時間の範囲の期間与える、前記方法。
- 約0.6mg/mL〜約3.0mg/mLのブプレノルフィンまたはその医薬として許容できる塩及び少なくとも1つの医薬として許容できる賦形剤を含む哺乳動物に対して皮下または筋肉内投与するための非徐放性組成物。
- 組成物は約1.8mg/mLのブプレノルフィンまたはその医薬として許容できる塩を含む、請求項20に記載の組成物。
- 組成物は約2.4mg/mLのブプレノルフィンまたはその医薬として許容できる塩を含む、請求項20に記載の組成物。
- 組成物は約3%〜5%(v/v)の等張化剤を含む、請求項20に記載の組成物。
- 組成物は約0.05〜約2.5mg/mLの少なくとも1つの抗微生物剤を含む、請求項20に記載の組成物。
- 組成物は約5%〜約20%のエタノールを含む、請求項20に記載の組成物。
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JPH07196510A (ja) * | 1993-12-28 | 1995-08-01 | Nippon Seiyaku Kk | 鎮痛薬含有注射用徐放性脂肪乳剤 |
US20090181068A1 (en) * | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
WO2010009451A2 (en) * | 2008-07-17 | 2010-01-21 | Merial Limited | Long-acting injectable analgesic formulations for animals |
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US5240711A (en) * | 1989-11-29 | 1993-08-31 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Transdermal therapeutic system comprising as active component buprenorphine |
US5968547A (en) * | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
EP0952869A1 (en) * | 1997-09-08 | 1999-11-03 | Vyteris, Inc. | Iontophoretic delivery of buprenorphine |
GB0201367D0 (en) * | 2002-01-22 | 2002-03-13 | Ml Lab Plc | Composition |
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JPH07196510A (ja) * | 1993-12-28 | 1995-08-01 | Nippon Seiyaku Kk | 鎮痛薬含有注射用徐放性脂肪乳剤 |
US20090181068A1 (en) * | 2008-01-14 | 2009-07-16 | Dunn Richard L | Low Viscosity Liquid Polymeric Delivery System |
WO2010009451A2 (en) * | 2008-07-17 | 2010-01-21 | Merial Limited | Long-acting injectable analgesic formulations for animals |
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