JP2013530239A

JP2013530239A - Ｐｉ３ｋ阻害剤としてのキノリン

Ｐｉ３ｋ阻害剤としてのキノリン Download PDF

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Publication number: JP2013530239A
Authority: JP; Japan
Prior art keywords: alkyl; haloalkyl; substituted; halo; cyano
Prior art date: 2010-06-30
Legal status : Withdrawn

Application number

JP2013518695A

Other languages

English (en)

Japanese (ja)

Other versions

JP2013530239A5 (enExample

Inventor

ドランスフイールド，ポール・ジヨン

Original Assignee

アムジエン・インコーポレーテツド

Priority date

2010-06-30

Filing date

2011-06-30

Publication date

2013-07-25

2011-06-30 Application filed by アムジエン・インコーポレーテツド filed Critical アムジエン・インコーポレーテツド

2013-07-25 Publication of JP2013530239A publication Critical patent/JP2013530239A/ja

2014-08-14 Publication of JP2013530239A5 publication Critical patent/JP2013530239A5/ja

Status Withdrawn legal-status Critical Current

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150000003248 quinolines Chemical class 0.000 title description 5
239000012828 PI3K inhibitor Substances 0.000 title description 4
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150000001875 compounds Chemical class 0.000 claims abstract description 79
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 19
208000035475 disorder Diseases 0.000 claims abstract description 12
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230000004054 inflammatory process Effects 0.000 claims abstract description 7
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208000030533 eye disease Diseases 0.000 claims abstract description 3
208000017520 skin disease Diseases 0.000 claims abstract description 3
125000000217 alkyl group Chemical group 0.000 claims description 225
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125000005843 halogen group Chemical group 0.000 claims description 41
229910052760 oxygen Inorganic materials 0.000 claims description 41
125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 39
229910052717 sulfur Inorganic materials 0.000 claims description 38
229920006395 saturated elastomer Polymers 0.000 claims description 36
125000004093 cyano group Chemical group *C#N 0.000 claims description 33
125000001424 substituent group Chemical group 0.000 claims description 33
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238000000034 method Methods 0.000 claims description 30
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125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 9
125000001188 haloalkyl group Chemical group 0.000 claims description 8
125000002950 monocyclic group Chemical group 0.000 claims description 8
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
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201000000596 systemic lupus erythematosus Diseases 0.000 claims description 5
229910052799 carbon Inorganic materials 0.000 claims description 4
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 4
239000003085 diluting agent Substances 0.000 claims description 4
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