JP2013515803A - Treatment method for treating the surface of a fluid dispensing device - Google Patents

Abstract

A treatment method for treating a surface of a fluid administration device, comprising: a thin film for preventing interaction between the fluid and the component on one or more support surfaces of the one or more component in contact with the fluid; A processing method comprising a process of forming using chemical grafting.
[Selection figure] None

Description

  The present invention relates to a surface treatment method for a fluid administration device.

  Fluid administration devices are known and consist of: That is, one or more reservoirs, a pump moving in the reservoir, a valve, a dosing member such as a piston, and a dosing head with a dosing opening. Dosing devices typically include components made from a variety of materials. Therefore, the reservoir may also be made of plastic or synthetic material, glass or metal. Of the various parts, pistons, gaskets, etc. are made from flexible plastic materials such as elastomers. Other parts (eg, crimp caps, springs, annuloplasty spheres) are usually made of metal. Particularly in the field of medicine, the risk of interaction between the fluid to be administered and the various materials may harm the fluid. An example of an interaction is the leaching of material molecules into a fluid. Especially in the case of nasal spray devices, the quality of some active ingredients, such as hormones, peptides, enzymes, etc., can be degraded by interaction.

  There are problems with all existing surface treatment methods. Thus, some methods are only suitable for use on flat surfaces. Also, other methods limit the choice of substrate (eg gold). Polymerization of molecules by plasma is complicated and expensive, and the resulting coating layer is difficult to control, and there is a problem of deterioration over time. Similarly, the polymerization of molecules by UV radiation is complex and expensive and only works when used with photosensitive molecules. The same applies to atom transfer radical polymerization (ATRP), which is again complex and expensive. Finally, the electrografting method is complex and requires that the support surface be conductive.

International Publication No. 2008/078052

An object of the present invention is to propose a surface treatment method that can avoid the above-mentioned problems.
Specifically, an object of the present invention is to provide a surface treatment method that is effective, long-lasting, pollution-free, and easy to implement.

  Accordingly, the present invention is a processing method for treating the surface of a fluid dispensing device, wherein the interaction between the fluid and the component is applied to one or more support surfaces of the one or more component in contact with the fluid. A processing method is provided that includes a process of forming a thin film for preventing the above-described problem using chemical grafting.

  In an effective implementation, the grafting process comprises a process of contacting the support surface in contact with a fluid with a solution containing one or more fixing agents, wherein the fixing agent is a cleaved aryl salt; Let it be one or more monomers or polymers selected from the group consisting of vinyl-terminated or acrylic-terminated siloxanes and vinyl monomers or acrylic monomers.

Effectively, the chemical graft creates a covalent bond between the thin film molecules and the support surface. This creates a strong and long lasting bond.
The chemical grafting is effectively performed in an aqueous medium. In this way, the chemical reaction can be used in a form that is harmless or safe and is not dangerous to the environment.
In practice, the cleavable aryl salt is selected from the group consisting of aryldiazonium salts, arylammonium salts, arylphosphonium salts, arylsulfonium salts, aryliodonium salts.

The cleaveable aryl salt is selected from compounds of the general formula: ArN ₂ ⁺ , X ⁻ (Ar represents an aryl group, X ⁻ represents an anion). The aryl group in the organic compound is a functional group derived from an aromatic ring.
In practice, the X ⁻ anion is an inorganic anion such as a halide such as I ⁻ , Cl ⁻ , Br ⁻ , halogenoboric acid such as tetrafluoroborate, an organic anion (alcolate, carboxylate, perchlorate, Sulfonates etc.).

In practice, the aryl group Ar can be selected from mono- or poly-substituted aromatic groups or heteroaromatic groups composed of one or more aromatic rings having 3 to 8 carbons. The heteroatom of the heteroaromatic compound is selected from N, O, P, and S. Substituents include alkyl groups and one or more heteroatoms (N, O, F, Cl, P, Si, Br or S).
In practice, the aryl group is selected from NO ₂ ; COH; CN; CO ₂ H; ketone; ester; amine; and aryl group substituted by an attracting group such as halogen.

In practice, the aryl group is selected from the group consisting of a phenyl group and a nitrophenyl group.
In practice, the cleaveable aryl salt is selected from the group consisting of: phenyldiazonium tetrafluoroborate; 4-nitrophenyldiazonium tetrafluoroborate; 4-bromophenyldiazonium tetrafluoroborate; 4-aminophenyldiazonium chloride. 4-aminomethylphenyldiazonium chloride; 2-methyl-4-chlorophenyldiazonium chloride; 4-benzoylbenzenediazonium tetrafluoroborate; 4-cyanophenyldiazonium tetrafluoroborate; 4-carboxyphenyldiazonium tetrafluoroborate; Acetamidophenyldiazonium tetrafluoroborate; 4-phenylacetic acid diazonium tetrafluoroborate; 2-methyl-4-[( - methylphenyl) diazenyl] benzene diazonium sulfate; 9,10-dioxo-9,10-dihydro-1-anthracene diazonium chloride; 4-nitronaphthalene tetrafluoroborate; naphthalene tetrafluoroborate.

In practice, the cleaveable aryl salt is selected from the group consisting of: 4-nitrophenyldiazonium tetrafluoroborate; 4-aminophenyldiazonium chloride; 2-methyl-4-chlorophenyldiazonium chloride; 4-carboxy Phenyldiazonium tetrafluoroborate.
In practice, the concentration of the cleaveable aryl salt ranges from 5 × 10 ⁻³ mol (M) to 10 ⁻¹ M.

In practice, the concentration of the cleaveable aryl salt is about 5 × 10 ⁻² M.
In practice, cleaveable aryl salts are prepared in situ.
It is effective that the chemical grafting process is started by chemically activating a diazonium salt for forming the anchor layer for the thin film.
As an effective configuration, the chemical grafting process is initiated by chemical activation.

In practice, the chemical activation is initiated by the presence of a reducing agent in the solution.
In practice, the solution shall contain a reducing agent.
The term “reducing agent” refers to a compound that donates electrons during a redox reaction. As one aspect of the present invention, the redox potential difference of the reducing agent with respect to the redox potential of the cleaveable aryl salt is in the range of 0.3 volts (V) to 3V.

In one aspect of the present invention, the reducing agent is a pulverizable reducing metal such as iron, zinc or nickel; a metal salt capable of taking the form of metallocene; organic reduction including hypophosphorous acid and ascorbic acid Selected from the group consisting of agents.
In practice, the concentration of the reducing agent is in the range of 0.005M to 2M.
In the implementation, the concentration of the reducing agent is about 0.6M.

In implementation, the thickness of the thin film is preferably less than 1 μm and is preferably in the range of 10 angstroms (Å) to 2000 Å. The range of 10 to 800 cm is effective, and the range of 400 to 1000 cm is preferable. It is impossible to obtain such a thin chemical graft layer with conventional coating techniques.
The term “vinyl-terminated or acrylic-terminated siloxane” refers to a saturated silicon formed of linear or branched chains of alternating silicon and oxygen atoms, with terminal vinyl or acrylic motifs. And oxygen hydride.

  In practice, vinyl-terminated or acrylic-terminated siloxanes are vinyl-terminated or acrylic-terminated polyalkylsiloxanes such as vinyl-terminated or acrylic-terminated polymethylsiloxanes; vinyl-terminated or acrylic-terminated polydimethylsiloxanes such as polydimethylsiloxane-acrylate (PDMS-acrylate). From the group consisting of vinyl-terminated or acrylic-terminated polyarylsiloxanes that are vinyl-terminated or acrylic-terminated polyphenylsiloxanes such as polyvinylphenylsiloxane; vinyl-terminated or acrylic-terminated polyarylalkylsiloxanes such as vinyl-terminated or acrylic-terminated polymethylphenylsiloxanes; Selected.

  In practice, the vinyl monomer or acrylic monomer may be vinyl acetate; acrylonitrile; methacrylonitrile; methyl methacrylate; ethyl methacrylate; butyl methacrylate; propyl methacrylate; hydroxyethyl methacrylate; hydroxypropyl methacrylate; glycidyl methacrylate; Acrylamide, which is methacrylamide including propyl, butyl, pentyl, hexyl; cyanoacrylate; diacrylate; dimethacrylate; triacrylate; trimethacrylate; tetraacrylate; tetramethacrylate; styrene and its derivatives; parachlorostyrene; N-vinylpyrrolidone; 4-vinylpyridine; 2-vinylpyridine; And, vinyl, acryloyl halides methacryloyl; divinylbenzene, are selected from the group consisting of.

In practice, a potential difference is applied to the solution.
The term “potential difference” means a redox potential difference measured between two electrodes.
In practice, the potential difference is applied from a generator connected to the two electrodes. The two electrodes may be the same or different and are immersed in the solution during the immersion process.
In practice, the electrodes are selected from stainless steel, steel, nickel, platinum, gold, silver, zinc, iron, copper. It may be an in pure form or an alloy.

In practice, the electrodes are made of stainless steel.
In practice, the potential difference applied from the generator is in the range of 0.1V to 2V.
In implementation, the value is about 0.7V.
In practice, the potential difference is generated by a chemical battery.
The term “chemical cell” means a cell consisting of two electrodes interconnected via an ion bridge. The two electrodes in the present invention are appropriately selected so that the potential difference is in the range of 0.1V to 2.5V.

In practice, a chemical cell is formed between two different electrodes immersed in a solution.
In practice, the electrodes are selected from nickel, zinc, iron, copper and silver. It may be a simple substance or an alloy.
In the implementation, the potential difference generated by the chemical battery is in the range of 0.1V to 1.5V.
In the implementation, the potential difference is about 0.7V.

In practice, the electrodes are chemically isolated in order to avoid contact between the substrate immersed in the bath in treatment (b) and the electrode similarly immersed in the bath in treatment (b). Yes.
In another embodiment, among the components, in particular the crimp cap, the spring or the annuloplasty sphere is made of metal.
In another embodiment, among the components, in particular, the piston and the gasket are made of a flexible material such as an elastomer.

In another embodiment, the component is made of a synthetic material such as polyethylene or polypropylene.
In another embodiment, among the components, the reservoir, in particular, is made of glass.
Effectively, the method further includes a process of forming one or more additional thin films on the support surface using chemical grafting.

Effectively, the method includes a process of using a chemical graft to form a first additional thin film on the support surface that prevents interaction with the fluid.
Effectively, the method uses a chemical graft on the support surface for the purpose of suppressing friction between two components that move relative to each other during operation of the fluid delivery device. A process of forming two additional thin films.

In a first variation, the one or more additional thin films are laminated in one or more successive chemical grafting processes each performed in a single-component bath.
In another variation, the one or more additional thin films are simultaneously laminated to the support surface in a single chemical grafting process performed in a multi-component bath.

Effectively, the fluid is a medicament which is nebulized in particular in the nasal or oral form.
More specifically, the present invention provides the use of methods similar to those described in WO 2008/078052. Described in the international publication is a method of providing an organic thin film on the surface of a rigid support under non-electrochemical conditions. Surprisingly, this type of method has been found to be suitable for forming a thin bactericidal or bacteriostatic film on a surface in contact with a pharmaceutical fluid in a nasal or oral dosage device. Such use of the above grafting method has never been considered.

In summary, the method aims to provide a thin film on the surface of a support made of various materials (hard plastic, soft plastic, metal, glass, etc.). The method mainly consists of a treatment in which the surface of the support is immersed in a liquid solution. The liquid solution includes one or more solvents and one or more fixing agents from which radical entities can be formed.
A “thin film” is a particularly organic polymer film, for example, that originates from a plurality of units of organic chemical species and is covalently bonded to the support surface on which the method is carried out. Specifically, the membrane includes one or more layers which are bonded to the support surface in the form of a covalent bond and are composed of structural units having similar properties. Depending on the thickness of the membrane, the binding force is provided by covalent bonds that occur between the various units.

The nature of the solvent used in connection with this process is protic or aprotic. The solvent is preferably soluble in the fixing agent.
The term “protic solvent” means a solvent containing one or more hydrogen atoms that can be released in proton form. The protic solvent may be selected from the group consisting of: Water; deionized water; distilled water (which may be acidified but not essential); acetic acid; hydroxylated solvents such as methanol and ethanol; low molecular weight liquid glycols such as ethylene glycol; and mixtures thereof. As a first example, the protic solvent may consist of a protic solvent alone or a mixture of different protic solvents. As another example, one or more aprotic solvents may be mixed in a protic solvent or a mixture of protic solvents. As will be appreciated, in this case, the resulting mixture must exhibit the characteristics of a protic solvent. A suitable protic solvent is acidified water, more specifically acidified distilled water or acidified deionized water.

The term “aprotic solvent” means a solvent that is not considered protic. Under non-extreme conditions, these solvents are not suitable for proton release and acceptance. The aprotic solvent is advantageously selected from dimethylformamide (DMF); acetone; dimethyl sulfoxide (DMSO).
The term “fixing agent” refers to any organic molecule suitable for chemisorption onto a support surface under certain conditions by radical reactions such as radical chemical grafting. Such molecules include at least one functional group suitable for reacting with a radical, and further include a reactive group that reacts with another radical after chemisorption. Thus, after the initial molecule has been grafted to the support surface, the molecule can form a polymer film and can subsequently react with other molecules present in the environment.

  The term “radical chemical grafting” specifically refers to the formation of a bond with the support surface in the form of a covalent bond using a molecular entity having an unpaired electron. The molecular entities in that case are generated independently of the support surface onto which they are grafted. Thus, as a result of the radical reaction, a covalent bond is first formed between the target support surface and the grafted fixer derivative, and then between the grafted derivative and the molecule present in the environment. Formed.

  The term “fixing agent derivative” specifically refers to a chemical unit derived from a fixing agent, which chemically reacts with the surface of a rigid substrate or other radicals by radical chemical grafting. It happens after As will be apparent to those skilled in the art, functional groups that react with other radicals after chemical absorption of the fixer derivative are distinct from functional groups that are particularly associated with covalent bonding to the surface of a rigid support. It is. It is effective to use a fixable aryl salt selected from the group consisting of: That is, aryldiazonium salt; arylammonium salt; arylphosphonium salt; arylsulfonium salt; aryliodonium salt.

As a modification of the direct covalent bonding to the support surface realized in an aqueous medium, a method of immersing the porous layer previously grafted can be used.
In an effective implementation of the invention, chemical grafting is used to form at least one additional thin film on a single support surface. This adds at least one other characteristic to the support surface. The fluid to be administered tends to adhere to the surface with which it comes into contact, which can in particular adversely affect the reproducibility of the single dose administered. As an effective point, according to the present invention, the first additional thin film that prevents the fluid from adhering to the surface of the support can be formed by chemical grafting. In addition, it is also effective to consider a usage in which the support surface is provided with the third characteristic by providing the second additional thin film using chemical grafting. For example, in a fluid dispensing device, some components move relative to each other and can become clogged due to friction, which prevents the device from operating properly. In addition, according to the present invention, as an effective point, the second additional thin film that suppresses friction between two components that move relative to each other during driving can be formed using a chemical graft. These additional thin films can also be provided by a continuous chemical grafting process. In that case, each round of chemical grafting can be carried out in a single element bath. It should be noted that these chemical grafting processes performed sequentially may be performed in any order. In the modified example, as an alternative, the additional thin film can be provided by a single chemical grafting process. In this case, the chemical grafting process is performed in a multi-element tank. It is also conceivable to combine these two modifications.

  INDUSTRIAL APPLICABILITY The present invention is used in a multi-use type device having a pump or a valve installed in a reservoir and continuously administering a predetermined amount a plurality of times by driving. The present invention is also used in a multi-use device, such as in a subdivided powder inhaler, having a plurality of separate reservoirs each containing a single dose of fluid. The present invention is also used in a one-time or two-time device where the piston moves directly in the reservoir each time it is driven. The present invention is used in particular for nasal or oral spray devices, eye drop administration devices, and syringe-type needle devices.

  It is another object of the present invention to form a thin film for preventing mutual interaction between the fluid and the component on one or more support surfaces of one or more components in contact with the fluid in the fluid administration device. And the use of the grafting method of the present invention.

  The example shown below was performed in a glass container. Except where noted, these examples were run under standard temperature and pressure conditions in air (about 23 ° C. at about 1 atmosphere (atm)). Unless otherwise stated, the reagents used are obtained and used directly on the market, and no additional purification treatment is performed. Steel samples were UV-ozone treated for 10 minutes at ambient temperature.

Example 1-Grafting of a poly (butyl methacrylate) (BUMA) barrier film onto a metal part of a pump The term "pump" refers to a manual fluid dispensing device having a pump body in which one or more pistons slide. Means.
First, sodium dodecyl sulfonate (0.283 grams (g), 0.5 × 10 ⁻³ mol (mol)) was dissolved in 33 milliliters (mL) of milli-Q (mQ) water. Butyl methacrylate (0.711 g, 5 × 10 ⁻³ mol) was added thereto to make an emulsion with strong magnetic stirring.

4-aminobenzoic acid ^{(0.686g, 7.5 × 10 -3 mol} ), (1.9mL in mQ water 30 mL) hydrochloric acid and hypophosphorous acid (3.2mL, 3.1 × 10 ^{- 2} mol). The solution was then added to the BUMA emulsion.
Then, a NaNO ₂ (0.328 g, 4.8 × 10 ⁻³ mol) solution in 30 mL of mQ water was added to the emulsion, and then a 316L stainless steel sphere and a spring pump sample were added.

After reacting for 30 minutes, the sample was removed, placed in a 10% solution of Palmolive wash, and rinsed at 40 ° C. with magnetic stirring. In rinsing, the 10% solution was sprayed in a water tank of mQ water. After rinsing, the sample was dried in nitrogen.
Grafts were confirmed by analysis of spheres by infrared reflection absorption spectroscopy (IRRAS) (Hyperion). There was a specific band of BUMA film every 1716 centimeters (cm ⁻¹ ).

  The effect of grafting on the sample was confirmed by a passivation test. To that end, a 100 g sample was mineralized in a 0.1 M hydrochloric acid solution at 40 ° C. for 15 hours (h). Then, 2 mL of the solution was collected. The pH was adjusted to 3.5 with 250 grams per liter (g / L) sodium acetate solution. 1 mL of a 1,10-phenanthroline solution was added to confirm the presence of iron ions (color red).

Example 2-Grafting a poly (dimethylsiloxane) (PDMS) barrier membrane onto a metal part of a pump First, sodium dodecylbenzenesulfonate (0.849 g, 1.5 × 10 ^-2 mol) was dissolved in 100 mL of mQ water. . Thereto was added vinyl terminated poly (dimethylsiloxane) (3 g at 10 g / L) and the resulting mixture was magnetically stirred to form an emulsion.

4-Aminobenzoic acid (2.058 g, 2.25 × 10 ⁻² mol) was added to a solution of hydrochloric acid (5.8 mL in 90 mL mQ water) and hypophosphorous acid (9.7 mL, 50%). Melted. The solution was then added to the PDMS emulsion.
Then, 90 mL of an aqueous NaNO ₂ solution (0.984 g, 1.44 × 10 ⁻² mol) was added to the emulsion, and then a 316L stainless steel sphere and a spring were added.

After reacting for 30 minutes, the sample was removed and rinsed in a 10% solution of Palmolive wash at 40 ° C. with ultrasonic agitation. In rinsing, the 10% solution was sprayed in a water tank. After rinsing, the sample was dried in nitrogen.
The sample thus treated passed the passivation test. The results obtained from the tests are summarized in the table below.

+++ Test result is positive (corrosion)
OOO test result is negative (no corrosion)
Example 3 Chemical Grafting of Acrylic PDMS Polymer Film onto Stainless Steel Strip in the Presence of Potential Difference First, a PE sample was placed in ethanol and ultrasonically cleaned for 5 minutes (power at 100 watts (w), temperature 40 ° C).

  A biphasic solution was prepared in two steps. First, the following were put in order in a beaker (1) with magnetic stirring at 300 rpm (rpm): PDMS-acrylate (1 g / L); ratio of 8.5 wt% (% wt) ( 4.37 g / L) Brij 35® solution in water; 33 mL deionized (DI) water. Then, emulsification was caused to occur for 15 minutes at 200 watts (W) (100%) while applying ultrasonic waves at a temperature of 40 ° C.

The following was then added to the beaker (2) with magnetic stirring (300 rpm): nitrobenzenediazonium tetrafluoroborate (0.05 mol / L); 130 mL DI water; hydrochloric acid (0.23 mol / L).
The contents of beaker (2) were poured into the emulsion of beaker (1). And stainless steel strips (2); galvanized wound steel wire (10 turns, ie about 25-30 centimeters (cm)); wound nickel (Ni) wire (10 turns, ie about 25-30) Centimeters (cm)) were placed in the beaker (1). A steel wire and a nickel wire were connected to a potentiostat, and an ammeter was connected in series. A potential difference of 0.5 V was applied from the potentiostat, and the current was measured with an ammeter over time.

  As a final step, after the assembly was prepared, hypophosphorous acid (0.7 mol / L) was added last, thereby initiating the reaction. After reacting at ambient temperature for 30 minutes, the stainless steel strip was removed. The rinse was then carried out sequentially in the order of water (a cascade), ethanol (one stage) and finally isopropanol. Rinsing was performed in a soxhlet for 16 hours.

By using a Soxhlet extractor, it became possible to confirm the state of chemical grafting of acrylic PDMS on the surface of the stainless steel strip.
Analysis by IR spectroscopy was performed. In the infrared spectrum, acrylic PDMS grafting could be confirmed by the presence of a unique band of 1260 cm ^-1 that corresponds to the vibration of the Si-CH ₃ bond.

The stainless steel strip also passed the passivation test.
It will be apparent to those skilled in the art that various modifications can be devised without departing from the scope of the invention as defined by the appended claims.

Claims (19)

A treatment method for treating a surface of a fluid administration device, comprising:
Forming a thin film using chemical grafting on one or more support surfaces of one or more components that are in contact with a fluid to prevent interaction between the fluid and the components;
A processing method characterized by the above. The grafting process comprises a treatment of contacting the support surface in contact with a fluid with a solution containing one or more fixing agents, the fixing agent being a cleaved aryl salt, a vinyl-terminated or acrylic-terminated siloxane, and One or more monomers or polymers selected from the group consisting of vinyl monomers or acrylic monomers,
The processing method according to claim 1. The chemical grafting creates a covalent bond between the thin film molecules and the support surface;
The processing method according to claim 1 or 2. The chemical grafting is carried out in an aqueous medium;
The processing method according to any one of claims 1 to 3. The cleaveable aryl salt is selected from the group consisting of aryldiazonium salts, arylammonium salts, arylphosphonium salts, arylsulfonium salts, and aryliodonium salts;
The processing method according to any one of claims 1 to 4, wherein: The reducing agent is
A reduced metal that is finely pulverized iron, zinc or nickel;
A metal salt capable of taking the form of a metallocene,
An organic reducing agent that is hypophosphorous acid or ascorbic acid;
Being selected from the group consisting of
The processing method according to any one of claims 1 to 5. The chemical grafting process is initiated by chemical activation;
The processing method according to any one of claims 1 to 6. The chemical activation is initiated by the presence of a reducing agent in solution;
The processing method according to claim 7. Vinyl-terminated or acrylic-terminated siloxanes
A vinyl terminated or acrylic terminated polyalkylsiloxane which is a vinyl terminated or acrylic terminated polymethylsiloxane;
A vinyl-terminated or acrylic-terminated polydimethylsiloxane that is polydimethylsiloxane-acrylate (PDMS-acrylate);
A vinyl-terminated or acrylic-terminated polyarylsiloxane that is a vinyl-terminated or acrylic-terminated polyphenylsiloxane that is polyvinylphenylsiloxane;
A vinyl-terminated or acrylic-terminated polyarylalkylsiloxane which is a vinyl-terminated or acrylic-terminated polymethylphenylsiloxane;
Being selected from the group consisting of
The processing method according to any one of claims 1 to 8. Vinyl monomer or acrylic monomer
Vinyl acetate; Acrylonitrile; Methacrylonitrile; Methyl methacrylate; Ethyl methacrylate; Butyl methacrylate; Propyl methacrylate; Hydroxyethyl methacrylate; Hydroxypropyl methacrylate; Glycidyl methacrylate; Diamide; Dimethacrylate; Triacrylate; Triacrylate; Tetramethacrylate; Tetramethacrylate; Styrene and its derivatives; Parachlorostyrene; Pentafluorostyrene; N-vinylpyrrolidone; 4-vinylpyridine; 2-vinylpyridine; and vinyl, acryloyl, methacryloyl halogens Things; be selected from divinyl benzene, the group consisting of,
The processing method according to any one of claims 1 to 9. A potential difference is applied to the solution;
The processing method according to any one of claims 1 to 10, wherein: The potential difference is applied from a generator connected to the two electrodes, which may be the same or different and are immersed in the solution during the immersion process,
The processing method according to claim 11. The potential difference is generated by a chemical battery,
The processing method according to claim 11. The crimp cap, spring or valve forming sphere that is the component is made of metal,
The processing method according to claim 1, wherein: The component piston or gasket is made of a flexible material, and the flexible material includes an elastomer.
The processing method according to claim 1, wherein: The component is made of a synthetic material, the synthetic material being polyethylene or polypropylene,
The processing method according to claim 1, wherein: The reservoir as the component is made of glass;
The processing method according to claim 1, wherein: The thickness of the thin film is less than 1 μm, preferably in the range of 10 to 2000 mm,
The processing method according to any one of claims 1 to 17, wherein:   Performing a process of forming a thin film in contact with the fluid and having anti-friction properties on one or more support surfaces of one or more movable components of the fluid dispensing device that move during operation of the fluid dispensing device; 19. Use of a processing method according to any one of claims 1 to 18 for the purpose of preventing interaction between the fluid and the component by