JP2013515268A5 - - Google Patents
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- Publication number
- JP2013515268A5 JP2013515268A5 JP2012546149A JP2012546149A JP2013515268A5 JP 2013515268 A5 JP2013515268 A5 JP 2013515268A5 JP 2012546149 A JP2012546149 A JP 2012546149A JP 2012546149 A JP2012546149 A JP 2012546149A JP 2013515268 A5 JP2013515268 A5 JP 2013515268A5
- Authority
- JP
- Japan
- Prior art keywords
- epithelial cells
- glomerular epithelial
- therapy
- urinary
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 63
- 210000002919 epithelial cell Anatomy 0.000 claims description 50
- 230000001434 glomerular Effects 0.000 claims description 50
- 238000002560 therapeutic procedure Methods 0.000 claims description 38
- 230000002485 urinary effect Effects 0.000 claims description 34
- 201000001474 proteinuria Diseases 0.000 claims description 24
- 210000002700 urine Anatomy 0.000 claims description 21
- 238000011123 anti-EGFR therapy Methods 0.000 claims description 8
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims description 6
- 239000002147 L01XE04 - Sunitinib Substances 0.000 claims description 6
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims description 6
- 229960000397 bevacizumab Drugs 0.000 claims description 6
- 238000000684 flow cytometry Methods 0.000 claims description 6
- 229960003787 sorafenib Drugs 0.000 claims description 6
- 229960001796 sunitinib Drugs 0.000 claims description 6
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims description 6
- 241000124008 Mammalia Species 0.000 claims description 4
- 241000282412 Homo Species 0.000 claims description 3
- 210000000557 podocyte Anatomy 0.000 claims description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28851409P | 2009-12-21 | 2009-12-21 | |
| US61/288,514 | 2009-12-21 | ||
| PCT/US2010/061543 WO2011084791A2 (en) | 2009-12-21 | 2010-12-21 | Early marker of proteinuria in patients treated with an anti-vegf treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515268A JP2013515268A (ja) | 2013-05-02 |
| JP2013515268A5 true JP2013515268A5 (https=) | 2014-02-06 |
| JP5753541B2 JP5753541B2 (ja) | 2015-07-22 |
Family
ID=44306097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012546149A Expired - Fee Related JP5753541B2 (ja) | 2009-12-21 | 2010-12-21 | 抗ｖｅｇｆ治療によって治療された患者におけるタンパク尿の初期マーカー |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20130034861A1 (https=) |
| EP (1) | EP2517014B1 (https=) |
| JP (1) | JP5753541B2 (https=) |
| AU (1) | AU2010339723B2 (https=) |
| BR (1) | BR112012017767A2 (https=) |
| CA (1) | CA2785273A1 (https=) |
| ES (1) | ES2530866T3 (https=) |
| WO (1) | WO2011084791A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090104649A1 (en) | 2007-06-11 | 2009-04-23 | Garovic Vesna D | Markers for preeclampsia |
| US20130034861A1 (en) | 2009-12-21 | 2013-02-07 | Mayo Foundation For Medical Education And Research | Early marker of proteinuria in patients treated with an anti-vegf treatment |
| WO2014104019A1 (ja) * | 2012-12-26 | 2014-07-03 | デンカ生研株式会社 | 尿中ポドサイトの検出方法 |
| WO2021055089A1 (en) * | 2019-09-20 | 2021-03-25 | The University Of North Carolina At Chapel Hill | Methods of identifying risk of bevacizumab-induced proteinuria and hypertension |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9306053D0 (en) | 1993-03-24 | 1993-05-12 | Nycomed Pharma As | Method and assay |
| WO2002037099A1 (en) | 2000-10-27 | 2002-05-10 | International Reagents Corporation | Method of diagnosing nephropathy |
| US7713705B2 (en) | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| WO2003075016A1 (en) | 2002-03-07 | 2003-09-12 | Cambridge University Technical Services Limited (Cuts) | Scd fingerprints |
| US20030198959A1 (en) * | 2002-03-28 | 2003-10-23 | Kurnit David M. | Methods and compositions for analysis of urine samples in the diagnosis and treatment of kidney diseases |
| GB0215509D0 (en) * | 2002-07-04 | 2002-08-14 | Novartis Ag | Marker genes |
| US7435419B2 (en) | 2002-07-19 | 2008-10-14 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating pre-eclampsia or eclampsia |
| JP2007532913A (ja) | 2004-04-16 | 2007-11-15 | ユニバーシティー オブ マサチューセッツ | 細胞内病原体の検出法および定量化法 |
| EP1786477A2 (en) * | 2004-08-17 | 2007-05-23 | Prolx Pharmaceuticals Corp. | Method of preselection patients for anti-vegf, anti-hif-1 or anti-thioredoxin therapy |
| US7790463B2 (en) | 2006-02-02 | 2010-09-07 | Yale University | Methods of determining whether a pregnant woman is at risk of developing preeclampsia |
| US7820159B2 (en) * | 2006-10-31 | 2010-10-26 | Instiute of Virology of the Slovak Academy of Sciences | MN/CA IX and EGFR pathway inhibition |
| WO2008075173A2 (en) * | 2006-12-15 | 2008-06-26 | Ruprecht-Karls-Universität Heidelberg | Methods for treating podocyte-related disorders |
| EP2146728A4 (en) | 2007-05-21 | 2010-12-29 | Univ Wake Forest Health Sciences | PROGENITOR CELLS FROM URINE AND METHODS FOR THEIR USE |
| US20090068683A1 (en) | 2007-06-11 | 2009-03-12 | Mayo Foundation For Medical Education And Research | Markers for preeclampsia |
| US20090104649A1 (en) | 2007-06-11 | 2009-04-23 | Garovic Vesna D | Markers for preeclampsia |
| CN101970486A (zh) * | 2007-10-25 | 2011-02-09 | 布里斯托尔大学 | 特异于血管内皮生长因子(vegf)的促血管发生同工型的抗体 |
| WO2010065968A1 (en) | 2008-12-05 | 2010-06-10 | Myriad Genetics, Inc. | Cancer detection markers |
| US20120164667A1 (en) | 2009-06-10 | 2012-06-28 | Masanori Hara | Method for test on diabetic nephropathy |
| US20130034861A1 (en) | 2009-12-21 | 2013-02-07 | Mayo Foundation For Medical Education And Research | Early marker of proteinuria in patients treated with an anti-vegf treatment |
| TWI762890B (zh) | 2010-05-12 | 2022-05-01 | 開曼群島商英瑞金公司 | 生物活性腎細胞 |
| AU2013267139B2 (en) | 2012-06-01 | 2018-11-01 | Mayo Foundation For Medical Education And Research | High-throughput early detection and point-of-care early detection of pregnant women susceptible to developing preeclampsia |
| WO2014055687A1 (en) | 2012-10-05 | 2014-04-10 | Hitachi Chemical Co., Ltd. | Urine exosome mrnas and methods of using same to detect diabetic nephropathy |
| US20170003299A1 (en) | 2013-11-27 | 2017-01-05 | Mayo Foundation For Medical Education And Research | Detecting podocyte injury in diabetic nephropathy and glomerulonephritis |
-
2010
- 2010-12-21 US US13/518,358 patent/US20130034861A1/en not_active Abandoned
- 2010-12-21 BR BR112012017767A patent/BR112012017767A2/pt not_active IP Right Cessation
- 2010-12-21 EP EP10842718.8A patent/EP2517014B1/en not_active Not-in-force
- 2010-12-21 AU AU2010339723A patent/AU2010339723B2/en not_active Ceased
- 2010-12-21 ES ES10842718T patent/ES2530866T3/es active Active
- 2010-12-21 WO PCT/US2010/061543 patent/WO2011084791A2/en not_active Ceased
- 2010-12-21 JP JP2012546149A patent/JP5753541B2/ja not_active Expired - Fee Related
- 2010-12-21 CA CA2785273A patent/CA2785273A1/en not_active Abandoned
-
2013
- 2013-05-20 US US13/898,124 patent/US9213038B2/en active Active
-
2015
- 2015-11-09 US US14/935,784 patent/US9765137B2/en active Active
-
2017
- 2017-09-13 US US15/703,676 patent/US10336822B2/en not_active Expired - Fee Related
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