JP2013212333A - Mixer, mixing support device and mixing method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a mixer for mixing a medical agent and a mixture liquid which blocks the medical agent within a closed space even when the medical agent leaks or volatilizes from a vessel, and prevents exposure of the medical agent from extending outward.SOLUTION: A mixer 1 mixes a medical agent stored in at least one medical agent vessel 50 and a mixture liquid stored in at least one mixture liquid vessel 60 using a syringe, and includes: a body part 10 having a closed space S1; a syringe-holding part 20 by which a communication part and the closed space can communicate with each other; a medical agent vessel-holding part 30 capable of holding the medical agent vessel while the insides of the medical agent vessel and the closed space can communicate with each other; and a mixture liquid vessel-holding part 40 capable of holding the mixture liquid vessel at the outside of the closed space while the inside of the mixture liquid vessel and the closed space can communicate with each other. The syringe-holding part can hold the syringe while the communication part is relatively movable in the closed space with respect to the insides of the medical agent vessel and the mixture liquid vessel so that the communication part communicates with the insides of the medical agent vessel and the mixture liquid vessel after the communication part communicates with the closed space.

Description

  The present invention relates to a medicine and mixed liquid mixing apparatus, a mixing support apparatus, and a mixing method.

  Conventionally, the health hazards of medical workers who handle cytotoxic drugs used in cancer chemotherapy and the like have been regarded as a problem. The reason for this is that cytotoxic drugs normally circulate in a state of being enclosed in containers, but medical personnel can dissolve, remove, or dilute drugs from these containers using a syringe. This is because, during such operations, the drug leaks or volatilizes, and the exposure to the drug occurs.

  Therefore, medical workers work in devices such as isolators and safety cabinets with caps, masks, gowns, gloves, etc., or use special instruments described in Patent Documents 1 and 2. doing. The special devices of Patent Documents 1 and 2 are devices that connect a drug container and a syringe for extracting the drug from the container. When the drug is extracted into the syringe, the drug leaks and the surrounding environment is exposed. It is to suppress.

Special table 2009-514641 gazette JP-T-2005-504609

  By the way, in order to finally administer the drug to the patient, for example, it is necessary to mix the drug and the mixed solution, such as transferring the drug extracted into the syringe to a container containing an infusion solution. There are many. However, in the method using an apparatus such as an isolator or a safety cabinet, the problem that various instruments are contaminated in the apparatus in the process of mixing the drug with the mixed solution has not been sufficiently solved. Then, the person who contacts the contaminated device may be exposed to the drug while the contaminated device is subsequently used for treatment or discarded. Here, examples of the instruments that are liable to be contaminated by a medicine include a syringe, a medicine container, a mixed liquid container, and the like. In addition, if the inside of a device such as an isolator or safety cabinet is contaminated with the above chemicals, the cleaning and removal of the device is very troublesome. In an extreme case, the entire device must be disposed of. But it becomes a big problem.

  On the other hand, it is difficult to sufficiently prevent contamination of various instruments used in the mixing operation of the drug and the mixed solution even with the technique using the special instruments of Patent Documents 1 and 2. For example, after removing the syringe containing the medicine from the special instruments of Patent Documents 1 and 2, the case where the medicine is leaked to the outside due to an erroneous operation or the like when the medicine in the syringe is transferred to the mixed solution container is completely considered. It is not, and cannot be declared completely safe. In the above, the case of handling a drug having cytotoxicity has been described. However, the present invention is not limited to this, and it is also applicable to the case of handling other drugs that may cause problems such as odor or irritation. A similar problem arises.

  In the present invention, when a drug and a mixed solution are mixed using a syringe, even if the drug leaks or volatilizes from the drug container, it remains in the closed space, and the exposure does not reach the outside. It is an object of the present invention to provide a mixing device, a mixing support device, and a mixing method for a medicine and a mixed solution that can be used.

  The mixing device according to the first aspect of the present invention is a mixing device housed in one or more medicine containers and a medicine housed in one or more medicine containers using a syringe having a flow part for sucking and discharging liquid. A mixing device for mixing with a liquid, a main body portion having a closed space, a syringe holding portion capable of holding the syringe in a state in which the circulation portion and the closed space can be communicated, and a medicine container In a state where the inside and the closed space can communicate with each other, a medicine container holding portion capable of holding the one or more medicine containers, and the inside of the mixed solution container and the closed space can be communicated with each other. A liquid mixture container holding part capable of detachably holding the liquid mixture container outside the closed space, wherein the syringe holding part is connected to the closed space and then the flow part is the drug. Container and liquid mixture As communication with the interior of said flow part is the closed space in a relatively movable state to the inside of the drug container and the mixture container is capable of holding the syringe.

  The “state in which communication is possible” according to the present invention includes not only a state in which space and space can communicate directly but also a state in which space and space can communicate through a third space. To do. Further, in a state where the space and the space can communicate with each other through the third space, after the first space communicates with the third space, the second space communicates with the third space. It is not necessary for the space and the second space to be simultaneously communicated with each other, and a state in which the space can be communicated at different timings through the third space is also included. Here, the “third space” is, for example, a syringe circulation part, and the state in which the closed space and the internal space of the liquid mixture container can communicate with each other via the syringe circulation part is “can communicate. It can be set as one mode of "state".

  According to this structure, it is comprised so that the distribution | circulation part of a syringe, the inside of a chemical | medical solution container, and the inside of a liquid mixture container can communicate with the closed space of a main-body part in the airtight state. And since the syringe is hold | maintained at the syringe holding | maintenance part so that the distribution | circulation part of a syringe can move the inside of a closed space, the distribution | circulation part of a syringe is inside a chemical | medical agent container and a liquid mixture container in a closed space. Can be accessed. Therefore, the medicine and the mixed solution can be mixed using the syringe in the closed space. As a result, even if the drug leaks or volatilizes from the drug container during the mixing operation of the drug and the liquid mixture, the drug stays in the closed space and does not reach the outside. In addition, the syringe holding part and the main body part may be integrally formed so that the boundary between them cannot be determined.

  A mixing apparatus according to a second aspect of the present invention is the mixing apparatus according to the first aspect, wherein the syringe holding part is configured to pass the flow part to the inside of the drug container and the mixed liquid container in the closed space. It can be flexibly deformed to move relatively.

  Here, since the syringe holding part is flexible, the circulation part of the syringe held by the syringe holding part can easily move in the closed space. Therefore, it is possible to make the circulation part of the syringe accessible to the inside of the drug container and the mixed liquid container with a simple configuration.

  The mixing apparatus which concerns on the 3rd viewpoint of this invention is a mixing apparatus which concerns on a 2nd viewpoint, Comprising: The said syringe holding part has a bellows structure. Therefore, here, the circulation part of the syringe can be freely moved in the closed space, such as being moved up and down or inclined.

  A mixing apparatus according to a fourth aspect of the present invention is the mixing apparatus according to any one of the first to third aspects, wherein the drug container holding unit has the circulation unit accessing the inside of the mixed solution container. The at least one drug container can be held in a state where the at least one drug container is inclined with respect to the direction.

  Here, a part or all of the drug containers are inclined with respect to the direction in which the flow part accesses the inside of the mixed liquid container. Therefore, even if the medicine in the container is sucked by the syringe and the amount of the liquid remaining in the container decreases, the remaining liquid tends to accumulate near the edge of the bottom surface of the tilted container. As a result, a part or all of the liquid in the medicine container can be easily sucked into the syringe.

  A mixing apparatus according to a fifth aspect of the present invention is the mixing apparatus according to any one of the first to fourth aspects, wherein the drug container holding portion is accommodated in the closed space, and the drug container is The drug container can be held so as to be accommodated in the closed space. That is, here, the medicine container is accommodated in the closed space. Therefore, even if the drug leaks or volatilizes from the drug container, it stays in the closed space and does not reach the outside.

  A mixing apparatus according to a sixth aspect of the present invention is the mixing apparatus according to any one of the first to fifth aspects, wherein the syringe holding part is configured such that the flow part is the one or more medicines in the closed space. The syringe can be held in a state in which it can relatively move between at least two of the container and the one or more liquid mixture containers. That is, here, the circulation part of the syringe rotates, so that the inside of at least two containers can be easily accessed.

  A mixing apparatus according to a seventh aspect of the present invention is the mixing apparatus according to any one of the first to sixth aspects, wherein the syringe holding part is configured such that the flow part is the one or more medicines in the closed space. The syringe can be held in a state in which it can relatively linearly move between at least two of the container and the one or more liquid mixture containers. That is, here, at least two containers can be accessed by the linear movement of the circulation part of the syringe.

  A mixing device according to an eighth aspect of the present invention is the mixing device according to any one of the first to seventh aspects, wherein the drug container holding portion is configured such that the insides of the plurality of drug containers are simultaneously or continuously. Each of the plurality of drug containers can be held so as to be able to communicate with the closed space. That is, here, a plurality of drug containers reach the closed space simultaneously or sequentially. Therefore, the medicines in a plurality of medicine containers can be mixed using the same closed space.

  A mixing apparatus according to a ninth aspect of the present invention is the mixing apparatus according to any one of the first to eighth aspects, wherein the main body part, the syringe holding part, the drug container holding part, and the mixed liquid container holding part. At least a part of the part is transparent so that the closed space can be seen from the outside. Therefore, it can be moved in the closed space while visually recognizing the circulation part of the syringe from the outside. Therefore, since the positioning of the flow part can be performed easily and accurately, the mixing operation can be performed easily and accurately.

  A mixing apparatus according to a tenth aspect of the present invention is the mixing apparatus according to any one of the first to ninth aspects, wherein the syringe container and the liquid mixture container lid when the syringe circulation portion has a needle When the part is pierced by the needle of the circulation part, the inside of each container communicates with the internal space of the syringe. For example, the opening of the drug container and the liquid mixture container is sealed with a lid portion formed of an elastic material such as an elastomer, and the syringe circulation portion formed by a needle or the like is pierced through the lid portion. The circulation part can easily access the internal space of the drug container and the mixed liquid container. If comprised in this way, since the cover part is formed with the elastic material, if the penetrated distribution | circulation part is extracted, the through-hole formed by the distribution | circulation part will be obstruct | occluded naturally. Therefore, the sealed state of each container is maintained even after the circulation part is extracted.

  A mixing apparatus according to an eleventh aspect of the present invention is the mixing apparatus according to any one of the first to ninth aspects, wherein the syringe holding part is connected to the flow part while holding the syringe. A needle is included in the enclosed space. That is, here, since the syringe is held against the mixing device via the syringe holding unit, the needle connected to the syringe is equipped in the mixing device as a part of the syringe holding unit. And by hold | maintaining the syringe without a needle | hook with a syringe holding | maintenance part, the distribution | circulation part of a syringe and the needle | hook of a syringe holding | maintenance part are connected. As a result, the needle that moves in the closed space while being held by the syringe holding part can be firmly fixed to the syringe holding part.

  A mixing support apparatus according to a twelfth aspect of the present invention is a mixing support apparatus that supports mixing of the drug and the mixed solution using the mixing apparatus according to any of the first to eleventh aspects. The direction of the syringe is changed by changing the direction of the mixing device in a state where the syringe and at least one of the one or more drug containers and the one or more mixed liquid containers are held. And an orientation changing mechanism for changing the orientation of the at least one container.

  Here, the direction of the mixing device is changed by the direction changing mechanism, and as a result, the direction of the syringe and the direction of at least one container are changed. Therefore, for example, it becomes easy to arrange the container directly above or obliquely above the syringe and allow the syringe to access the inside of the container from directly below or obliquely below. As a result, the liquid in the container can be easily sucked into the syringe.

  A mixing support apparatus according to a thirteenth aspect of the present invention is the mixing support apparatus according to the twelfth aspect, wherein the circulation part of the syringe held by the syringe holding part is placed in the closed space with the 1 The apparatus further includes a moving mechanism for relatively moving between at least two of the drug container and the one or more liquid mixture containers.

  Here, the moving mechanism makes it easy to relatively move the circulation part of the syringe between at least two containers. Therefore, the circulation part of the syringe can easily access the inside of at least two containers.

  A mixing support apparatus according to a fourteenth aspect of the present invention is the mixing support apparatus according to the twelfth aspect or the thirteenth aspect, further comprising a control unit that controls at least one of the direction changing mechanism and the moving mechanism. . That is, here, at least one of the operation of changing the orientation of the mixing device by the orientation changing mechanism and the operation of moving the syringe relative to the container by the moving mechanism is automated. Therefore, the burden on the user related to the mixing work is reduced.

  A mixing support apparatus according to a fifteenth aspect of the present invention is the mixing support apparatus according to any one of the first to fourteenth aspects, wherein the syringe holding part can communicate the circulation part and the closed space. A plurality of the syringes can be held in a state. Therefore, here, it becomes possible to mix the medicine accommodated in one or more medicine containers and the liquid mixture accommodated in one or more liquid mixture containers using a plurality of syringes.

  The mixing method according to the sixteenth aspect of the present invention includes a step of preparing a syringe having a flow part for sucking and discharging a liquid, a step of preparing a mixing device having a closed space, and one or more drugs containing a drug. A step of holding the one or more drug containers with respect to the mixing device in a state where the inside of the container and the closed space can be communicated, and a state where the circulation portion and the closed space can be communicated. The one or more mixed solution containers are connected to the mixing device outside the closed space in a state in which the step of holding the mixing device and the inside of the mixed solution container containing the mixed solution and the closed space can communicate with each other. The step of detachably holding the flow portion, and the flow portion so that the flow portion communicates with the inside of the drug container and the liquid mixture container after the flow portion is communicated with the closed space. While moving relative to the inside of the drug container and the liquid mixture container in the closed space, the drug and the liquid mixture are placed inside at least one of the syringe, the drug container, and the liquid mixture container. Generating a mixed chemical solution.

  Here, the circulation part of the syringe, the inside of the chemical liquid container, and the inside of the mixed liquid container can communicate with the closed space of the main body part in a sealed state. And when the circulation part of a syringe moves in the closed space, the inside of the medicine container and the mixed liquid container can be accessed. Therefore, when the drug and the mixed solution are mixed using a syringe to produce a mixed drug solution, even if the drug leaks or volatilizes from the drug container, it remains in the closed space and exposed to the outside. Can be overdue.

  A mixing method according to a seventeenth aspect of the present invention is the mixing method according to the sixteenth aspect, wherein the step of generating the mixed drug solution is configured such that the flow part is connected to the drug container so that the flow part communicates with the drug container. Moving relative to the inside of the medicine container in a closed space; connecting the flow part to the inside of the medicine container; and then sucking the medicine into the syringe; and into the syringe Moving the flow part relative to the inside of the liquid mixture container in the closed space so that the flow part communicates with the liquid mixture container after the drug is sucked; and Injecting the drug in the syringe into the mixed solution container after communicating with the mixed solution container.

  Here, the mixed solution container containing the mixed drug solution is generated in a state in which the drug is not exposed to the outside of the closed space. Accordingly, it is possible to prepare a safe mixed solution container containing a mixed chemical solution used for administration of a drug to a patient.

  A mixing method according to an eighteenth aspect of the present invention is the mixing method according to the seventeenth aspect, wherein the liquid container is removed from the mixing device, and the drug container and the syringe are held with respect to the mixing device. The step of discarding the mixing device, the drug container, and the syringe is further provided.

  Here, after a mixed liquid container containing a mixed chemical liquid is generated, the container is removed from the mixing apparatus and used for administration of a drug to a patient or the like. On the other hand, the drug container and the syringe are discarded without being removed from the mixing device, and are integrated with the mixing device. Therefore, even if the drug leaks or volatilizes in the device, the contaminated part remains in the closed space in the process of disposal of the mixing device, drug container and syringe contaminated with the drug, Exposure is not reached. As a result, it is possible to safely discard the mixing device, the drug container, and the syringe contaminated with the drug while preparing a safe mixed liquid container containing the mixed drug solution.

  According to the present invention, when mixing a drug and a liquid mixture using a syringe, even if the drug leaks or volatilizes from the drug container, it remains in the closed space and is exposed to the outside. Can be eliminated.

It is an external appearance perspective view of the mixing apparatus of the state holding the chemical | medical agent container and the liquid mixture container based on 1st Embodiment. It is an external appearance perspective view which shows the syringe holding part of the state which hold | maintained the syringe based on 1st Embodiment. It is operation | movement explanatory drawing which shows the mixing operation | work of the chemical | medical agent and liquid mixture using the mixing apparatus which concerns on 1st Embodiment. It is sectional drawing which shows a mode that the liquid mixture container based on the modification of 1st Embodiment was hold | maintained at the liquid mixture container holding | maintenance part. It is a perspective view which shows a mode that the liquid mixture container based on another modification of 1st Embodiment was hold | maintained at the liquid mixture container holding | maintenance part. It is sectional drawing which shows a mode that the syringe based on another modification of 1st Embodiment was hold | maintained at the syringe holding part. It is an external appearance perspective view of the mixing device of the state which hold | maintained the syringe and chemical | medical agent container based on 2nd Embodiment. It is a top view of the mixing apparatus which concerns on 2nd Embodiment. It is a top view of the medicine container holding part concerning a 2nd embodiment. It is operation | movement explanatory drawing which shows the mixing operation | work of the chemical | medical agent and liquid mixture using the mixing apparatus which concerns on 2nd Embodiment. It is an external appearance perspective view of the mixing apparatus which concerns on 3rd Embodiment. It is operation | movement explanatory drawing which shows the mixing operation | work of the chemical | medical agent and liquid mixture using the mixing apparatus which concerns on 3rd Embodiment. It is sectional drawing of the mixing apparatus of the state which hold | maintained the syringe, chemical | medical agent container, and liquid mixture container based on 4th Embodiment. It is operation | movement explanatory drawing which shows the mixing operation | work of the chemical | medical agent and liquid mixture using the mixing apparatus which concerns on 4th Embodiment. It is a figure which shows the mixing assistance apparatus of the state which supported the mixing apparatus based on 5th Embodiment. It is a figure which shows the positional relationship of the bottom face part of a mixing device and the supporting member of a mixing assistance apparatus based on 5th Embodiment. It is operation | movement explanatory drawing which shows the mixing operation | work of the chemical | medical agent and liquid mixture using the mixing assistance apparatus and mixing apparatus which concern on 5th Embodiment. It is another operation | movement explanatory drawing which shows the mixing operation | work of the chemical | medical agent and liquid mixture using the mixing assistance apparatus and mixing apparatus which concern on 5th Embodiment. It is a figure which shows the guide plate of the mixing apparatus which concerns on a modification. It is a figure which shows the needle | hook with a soft sheath which concerns on a modification. It is a figure which shows the needle | hook which has two flow paths in the inside which concerns on a modification. It is a figure which shows a mode that the closed space and mixed liquid container holding | maintenance part based on the modification were connected with the tube. It is an external appearance perspective view of the mixing apparatus which is hard to roll concerning the modification. It is a figure which shows the mixing assistance apparatus of the state which supported the mixing apparatus based on a modification.

  Hereinafter, first to fifth embodiments of a mixing device, a mixing support device, and a mixing method according to the present invention will be described with reference to the drawings.

<1. First Embodiment>
<1-1. Configuration of mixing device>
The mixing apparatus 1 according to the present embodiment mixes the medicine accommodated in the medicine container 50 and the mixture liquid contained in the mixture liquid container 60 using the syringe 70 to generate a mixed medicine liquid. The device used. The drugs targeted here are mainly cytotoxic drugs, and if exposed to them, those who handle them (mainly medical workers; hereinafter referred to as users) will have serious side effects or may be cytotoxic. It is a drug that may cause health damage or the like. Examples of such drugs include antineoplastic agents, antiviral agents, antibiotics, radiopharmaceuticals and the like. The mixed solution is a solution for diluting or dissolving a drug, such as physiological saline, Ringer's solution, or distilled water. In addition, mixing of a medicine here is performed in order to manufacture a mixing drug solution in the dispensing action performed by a doctor, a dentist, or a veterinarian's prescription, the action which a patient mixes himself, or a pharmaceutical company etc., for example. It is an act or the like, and means an arbitrary act of generating a mixed drug solution obtained by mixing a drug and a mixed solution.

  Hereinafter, the mixing apparatus 1 will be described with reference to FIGS. 1 and 2. FIG. 1 is an external perspective view of the mixing apparatus 1 in a state where a drug container 50 and a mixed liquid container 60 are held according to this embodiment, and FIG. 2 is a syringe holding state in which a syringe 70 is held according to this embodiment. FIG. As shown in FIG. 1, the mixing apparatus 1 includes a transparent main body 10 having a substantially truncated cone shape, and a drug container holding unit for holding a plurality of drug containers 50 inside the main body unit 10. The part 30 is accommodated. Moreover, the syringe holding part 20 for holding the syringe 70 mentioned above is attached to the top part of the main-body part 10, and also the liquid mixture container holding part to which the liquid mixture container 60 is attached to the bottom face side of the main-body part 10. 40 is attached. In the following description, the direction in which the axis A1 of the substantially truncated cone-shaped main body 10 extends is defined as the axial direction, and the radial direction and the circumferential direction are defined with reference to the axis A1. The direction may be described with the top side of the main body 10 being “up” and the bottom side being “down”.

  First, the syringe 70, the medicine container 50, and the mixed solution container 60 used for mixing medicines in the mixing apparatus 1 will be described. As shown in FIG. 2, a known syringe 70 can be used, and includes a cylindrical cylinder 71 and a piston 72 that moves within the cylinder 71. An opening for sucking and discharging the liquid is provided at the tip of the cylinder 71, and a needle 73 is attached to the opening. In the present embodiment, the opening and the needle 73 constitute the flow part of the present invention.

  As shown in FIG. 1, the medicine container 50 includes a glass bottle main body 51 and a bottle stopper 52 that closes an opening formed in the upper portion of the bottle main body 51. Although the bottle main body 51 is formed in a substantially cylindrical shape as a whole, a neck portion 51a (see FIG. 3) having a small diameter is formed on the upper end portion via a shoulder portion 51b, and a bottle stopper 52 is formed on the neck portion 51a. Is installed. The bottle stopper 52 is wound and fixed to the neck portion 51a with aluminum or the like so as to close the opening of the bottle main body 51, but the portion closing the opening of the bottle main body 51 is made of an elastically deformable material such as rubber or elastomer. The needle 70 of the syringe 70 can be pierced. In addition to the liquid, there are powders and the like as the medicine, but all are sealed in the medicine container 50 by the structure as described above.

  The liquid mixture container 60 includes a plastic bottle main body 61 and a bottle stopper 62 (see FIG. 3) that closes an opening formed in the upper portion of the bottle main body 61. Although the bottle main body 61 is formed in a substantially elliptical column shape as a whole, a neck portion 61a having a small diameter is formed on the upper end portion via a shoulder portion 61b, similar to the medicine container 50, and the neck portion 61a A bottle stopper 62 is attached. The bottle stopper 62 is attached to the neck portion 61 a by welding so as to close the opening of the bottle body 61. In the bottle stopper 62, the portion (lid) that closes the opening of the bottle main body 61 is formed of an elastic material such as rubber or elastomer like the medicine container 50, and can be pierced by the needle 73 of the syringe 70. .

  Next, the mixing apparatus 1 will be described. First, the main body unit 10 and the syringe holding unit 20 will be described. The main body 10 is made of a transparent material such as polycarbonate, and has a substantially truncated cone shape as described above. More specifically, it has a bottom surface portion 10a, a bottom surface portion 10a and a conical surface portion 10b that is detachable, and an opening is formed at the top portion. And the substantially conical syringe holding | maintenance part 20 is attached so that this opening may be plugged up, and the main-body part 10 and the syringe holding | maintenance part 20 are formed in the substantially conical shape as a whole. As a result, a closed space S1 is formed inside the main body 10 and the syringe holding unit 20 as a work space for mainly performing a mixing operation of the medicine and the mixed liquid, and the liquid and gas in the closed space S1 are externally provided. It is designed not to leak. In other words, the main body part 10 and the syringe holding part 20 are wall members that partition the closed space S1 from the external space where the user exists. However, since the main body part 10 is transparent, the inside of the closed space S1 is visible from the outside. It is possible. In the main body 10, the method of configuring the bottom surface 10a and the conical surface portion 10b so as to be separable and fixed is not particularly limited as long as the medicine and the mixed liquid do not leak, but a circular shape is formed inside the lower portion of the conical surface portion 10b. Any known method can be adopted by those skilled in the art, such as enabling the bottom surface portion 10a to be fitted into a rail formed along the circumferential direction.

  The vicinity of the approximate center of the bottom surface portion 10a of the main body portion 10 is recessed in a dome shape toward the closed space S1, that is, upward. Thereby, a dome-shaped space (hereinafter referred to as a dome space) S <b> 3 is formed on the bottom surface portion 10 a of the main body portion 10. An opening is formed at the top of the dome space S3, that is, at the center of the bottom surface portion 10a of the main body portion 10, and the liquid mixture is placed on the closed space S1 side of the bottom surface portion 10a so as to airtightly close the opening. A container holding unit 40 is attached. The mixed liquid container holding portion 40 has a substantially cylindrical outer shape made of an elastic material such as rubber or elastomer, and is formed in a cup shape having a concave portion below. And the bottle stopper 62 of the liquid mixture container 60 inserted from opening of the bottom face part 10a of the main-body part 10 fits in this recessed part. At this time, the bottle stopper 62 is pressure-bonded to the mixed liquid container holding part 40 which is an elastic body, and the mixed liquid container 60 is held by the mixed liquid container holding part 40. On the other hand, the upper part of the mixed liquid container holding part 40 is formed of an elastic material as described above, and the needle 71 of the syringe 70 is pierced here, passes through the opening of the bottom part 10a, and reaches the bottle stopper 62. It is designed to be pierced. In addition, as shown in FIG. 4, the downward convex part 40a can be formed in the center of the lower surface of the liquid mixture container holding | maintenance part 40, ie, the surface facing the bottle stopper 62 of the liquid mixture container 60. As shown in FIG. Thereby, when the liquid mixture container 60 is mounted, the convex portion 40 a is pushed into the bottle stopper 62, so that the liquid mixture container holding part 40 and the bottle stopper 62 are in particular in close contact with each other. Therefore, if the needle 73 of the syringe 7 is inserted into this portion, the leakage of the chemical solution can be prevented more reliably.

  A drug container holding unit 30 that holds the drug container 50 is attached to the upper surface of the mixed liquid container holding unit 40. The medicine container holding unit 30 has a dish shape and is substantially circular in a plan view. More precisely, the medicine container holding part 30 has a flat, substantially circular bottom part 31 and a substantially donut-shaped edge part 32 that extends obliquely upward and radially from the bottom part 31. Is fixed to the upper surface of the mixed liquid container holding part 40. Further, a through-hole is formed in the bottom surface portion 31, and the needle 73 of the syringe 70 is pierced into the mixed liquid container holding portion 40 through the through-hole, as will be described later.

  A plurality of (six in this embodiment) cutouts 30a are formed on the edge portion 32 of the drug container holding portion 30 at substantially equal intervals along the outer peripheral edge thereof. The drug containers 50 are respectively held in the notches 30a. Each notch 30 a is formed in a semicircular shape, and its radius is substantially the same as the outer diameter of the neck portion 51 a of the medicine container 50. Therefore, the neck portion 51 a of each medicine container 50 is firmly engaged with each notch 30 a, and the medicine container 50 is held by the medicine container holding portion 30. More specifically, the six portions of the medicine container holding part 30 that respectively define the outlines of the six notches 30a are in firm contact with the neck part 51a, the shoulder part 51b, and the lower part of the bottle stopper 52 of the medicine container 50. Then, the medicine container 50 is fixed. 1 shows a state in which four drug containers 50 are fixed to the four notches 30a. However, all the drug containers 50 are held in the drug container holding part 30 in the main body part. 10 is accommodated in the closed space S1.

  Moreover, the medicine container holding part 30 has a dish shape as described above. Therefore, the medicine container 50 fixed to the medicine container holding part 30 is arranged radially around the axis A1, and the longitudinal axis thereof is arranged in an acute angle with respect to the axis A1. In other words, the bottle stopper 52 of each medicine container 50 is disposed so as to face radially inward and upward of the axis A1, and the bottom surface of each medicine container 50 faces radially outward and downward. Thereby, the bottom surface of each medicine container 50 is inclined at an acute angle with respect to the axis A <b> 1 while being held by the medicine container holding portion 30, and all face different directions.

  Thus, in a state where the mixed solution container 60 and the drug container 50 are attached to the main body portion 10, the central axis (a line passing through the center of the bottom surface and perpendicular to the bottom surface) of the mixed solution container 60 extends substantially along the axis A1. It becomes the state. Therefore, the bottom surface of the mixed solution container 60 fixed to the mixed solution container holding unit 40 and the bottom surface of the maximum six drug containers 50 fixed to the drug container holding unit 30 all have different directions. It will turn.

  As described above, since the bottle stoppers 52 and 62 of the containers 50 and 60 and the mixed liquid container holding part 40 are formed of an elastic material such as rubber or elastomer, the needle 73 of the syringe 70 is pierced. Later, even if this is pulled out, the through hole formed by the needle is naturally closed. The main body 10 that is closed by the containers 50 and 60 and the mixed liquid container holder 40 is kept airtight and prevents leakage and volatilization of the medicine.

<1-2. Mixing method using mixing device>
Next, the flow of the mixing operation of the medicine and the mixed solution using the mixing device 1 and the syringe 70 will be described in detail with reference to FIG. Here, the medicine in the medicine container 50 is assumed to be a liquid unless otherwise specified.

  First, the user prepares the mixing device 1, the syringe 70, the plurality of medicine containers 50, and the mixed liquid container 60 described above. Next, the bottom surface part 10a is removed from the main body part 10 of the mixing apparatus 1, and the drug container holding part 30 is exposed to the outside. Then, the user hooks the necessary number of neck portions 51 a and shoulder portions 51 b of the medicine container 50 into the notches 30 a of the medicine container holding portion 30. Thereby, the medicine container 50 is held with respect to the medicine container holding part 30. When the fixing operation is completed, the bottom surface portion 10a and the conical surface portion 10b are fixed again, and the plurality of medicine containers 50 are accommodated in the closed space S1.

  Subsequently, the user inserts the neck portion 61 a of the mixed solution container 60 into an opening formed in the bottom surface portion 10 a of the main body portion 10. Thus, the neck portion 61 a is inserted into the concave portion of the mixed liquid container holding unit 40 through the opening, and the mixed liquid container 60 is held by the mixed liquid container holding unit 40. At this time, the liquid mixture container 60 is detachably held with respect to the liquid mixture container holding part 40 outside the closed space S1. Further, in this state, the bottle stopper 62 of the mixed liquid container 60 and the mixed liquid container holding part 40 are arranged in close contact with each other, and a needle 73 of a syringe 70 described later can enter the mixed liquid container 60 from the closed space S1. It becomes. As described above, in the state where the medicine container 50 is sealed in the closed space S1 of the mixing device 1, exposure of the medicine is prevented. In addition, since the bottle stopper 62 is hermetically fixed to the liquid mixture container holding unit 40, the liquid mixture container 60 is attached to the mixing apparatus 1 so that the opening of the liquid mixture container 60 is not exposed to the outside. ing.

  The liquid mixture container 60 is detachable from the liquid mixture container holding part 40, but a known fixture such as a jar is used so as not to be unintentionally detached from the liquid mixture container holding part 40. Devices such as mounting on the outside can be added as appropriate. Specifically, as shown in FIG. 5, a pair of fan-shaped flat pressing members 41, 41 may be added. FIGS. 5A and 5B show a state in which the mixed solution container 60 held in the mixed solution container holding unit 40 is viewed obliquely from below. The holding members 41, 41 are disposed on the bottom surface of the mixed liquid container holding part 40 at a position approximately 180 ° apart in the circumferential direction centering on the neck part 61 b of the mixed liquid container 60, and the shaft 41 a The center can be rotationally moved between the position of FIG. 5A and the position of FIG. 5B. In the state of FIG. 5A, the mixed liquid container 60 can be pulled out from the mixed liquid container holding portion 40, while in the state of FIG. 5B, the bottle stopper 62 is supported by the pressing members 41, 41 from below. Therefore, it cannot be pulled out.

  Next, the syringe 70 is prepared. As the syringe 70 prepared here, it is preferable to prepare a syringe having a drop-off preventing mechanism that prevents the piston 72 from easily falling off from the cylinder 71. In addition, the syringe 70 is covered with a film, and even if the piston 72 is dropped from the cylinder 71 or a gap is generated between the cylinder 71 and the piston 72, the syringe 70 is sucked into the internal space S2 of the syringe 70. It is preferable to prevent the drug from being released into the external space.

  As described above, when the drug container 50 and the mixed solution container 60 are attached to the mixing device 1, the user pierces the needle 73 of the syringe 70 through the upper end surface 20a of the syringe holding unit 20, and is shown in FIG. In this manner, the entire syringe 70 is held against the syringe holding unit 20. The needle 73 of the syringe 70 is pierced substantially perpendicularly from the outside to the inside of the closed space S1 with respect to the thin upper end surface 20a of the syringe holding unit 20. As a result, the closed space S1 is in communication with the needle 73 of the syringe 70 and eventually the internal space S2 of the syringe 70 via the internal flow passage.

  Here, by setting a needle in advance in the closed space S1 and inside the upper end surface 20a of the syringe holding part 20, and connecting the tip of the cylinder of the needleless syringe to the upper end surface 20a from the outside, The opening (circulation part) at the tip and the needle can be connected. In that case, it is preferable to take measures such as installing a plug provided with a slit on the upper end surface 20a so that the tip of the cylinder can be inserted. Moreover, in order to connect both in a luer lock type so that the syringe 70 may not come out of the syringe holding part 20, it is also possible to provide a thread that engages with each other at the connecting part.

  In order to hold the syringe 70 more securely and prevent the medicine from leaking, the syringe holding part 20 may be provided with a cylindrical protruding part so as to be in close contact with the outer peripheral surface of the cylinder 71. It may be wound and fixed with a pinch cock or the like. Alternatively, as shown in FIG. 6 (a), a cylindrical elastic thin film 21 is installed in place of the cylindrical protrusion, and the elastic thin film 21 is attached as shown in FIG. 6 (b). It is also possible to take a means of returning the cylinder 71 in close contact with the outer peripheral surface.

  Next, the user moves the needle 73 of the syringe 70 relative to the openings of the medicine container 50 and the liquid mixture container 60 in the closed space S1, and the medicine, the liquid mixture, and the liquid inside the liquid mixture container 60. To produce a mixed chemical solution. That is, the user repeats the following procedure until the necessary amount of medicine is sucked from the medicine container 50 using the syringe 70 and injected into the mixed solution container 60. For example, in the case of an anticancer agent, the amount of the necessary drug is a dose of the drug required for the patient, which is determined according to the body surface area, weight, age, etc. of the patient.

  First, the user moves the needle 73 with respect to the bottle stopper 52 of any medicine container 50 while holding the cylinder 71 of the syringe 70 by hand. At this time, the user can contract and expand the bellows-structured syringe holder 20 in any direction, up, down, left, and right, so that the needle 73 is oriented substantially perpendicular to the thin portion of the bottle stopper 52. Thus, when the positioning of the needle 73 of the syringe 70 is completed, the needle 73 is pierced through the thin portion of the bottle stopper 52 as shown in FIG. Thereby, the internal space S <b> 2 of the syringe 70 is communicated with the internal space of the medicine container 50 through the needle 73 of the syringe 70. At this time, the needle 73 of the syringe 70 is pierced substantially perpendicularly from the outside of the drug container 50 to the inside of the drug container 50 with respect to the thin portion of the bottle stopper 52.

  Next, the user draws the medicine in the medicine container 50 into the internal space S <b> 2 of the syringe 70 by pulling the piston 72 of the syringe 70 in the direction in which the piston 72 is pulled out from the internal space S <b> 2 of the cylinder 71. Thereafter, the user pulls out the needle 73 of the syringe 70 from the bottle stopper 52 of the medicine container 50.

  Subsequently, after positioning the needle 73 of the syringe 70 along the axis A1, the user moves the needle 73 downward in the direction of the axis A1. That is, the needle 73 is inserted into the through hole of the bottom surface portion 31 of the drug container holding unit 30 and is further moved downward, so that the liquid mixture container holding unit 40 and the liquid mixture container 60 are moved as shown in FIG. The bottle stopper 62 is pierced. Thus, the internal space S2 of the syringe 70 is communicated with the internal space of the mixed liquid container 60 via the needle 73 of the syringe 70. In this state, by pushing the piston 72 of the syringe 70 into the internal space S2 of the cylinder 71, the medicine in the internal space S2 is injected into the mixed liquid container 60. Thereafter, the user pulls out the needle 73 of the syringe 70 from the bottle stopper 62 of the mixed solution container 60 and the mixed solution container holding unit 40.

  In the above steps, the drug is sucked from one drug container 50 and injected into the mixed solution container 60. However, if necessary, the drug is also sucked from the other drug containers 50, and the mixed solution container Inject at 60. In this way, a plurality of drugs are mixed in the mixed solution container 60 to generate a mixed drug solution. That is, by the above steps, the mixed drug solution is generated in the mixed solution container 60 in a state where the drug is not exposed to the outside of the closed space S1.

  Following this, the user removes the mixed liquid container 60 from the mixed liquid container holding part 40 by pulling it strongly downward while turning the mixed liquid container 60. Thereafter, the user carries the mixed liquid container 60 containing the mixed chemical liquid to the patient and administers the mixed chemical liquid in the mixed liquid container 60 to the patient by a method such as instillation. Subsequently, the user discards the mixing device 1, the medicine container 50, and the syringe 70 while the medicine container 50 and the syringe 70 are attached to the mixing device 1. That is, the medicine container 50 and the syringe 70 are discarded while being integrated with the mixing device 1 without being removed from the mixing device 1. Therefore, in the process of disposal of the mixing device 1, the drug container 50, and the syringe 70 contaminated with the drug, those contaminated parts are not exposed outside the closed space S1. This is because the operation until the mixed chemical solution is generated is performed in a state where the sealed state is maintained mainly in the closed space S1 closed from the external space and in the internal space S2 of the syringe 70. Therefore, the mixing device 1, the medicine container 50, and the syringe 70 contaminated with the medicine can be safely discarded.

  In the above process, the case where the liquid medicine is accommodated in the medicine container 50 has been described. However, when the powder medicine is contained in the medicine container 50, the medicines are mixed as follows. First, the syringe 70 is attached to the syringe holding unit 20, and after the mixed solution is sucked into the syringe 70 from the mixed solution container 60, the mixed solution in the syringe 70 is injected into the medicine container 50. As a result, the powdered drug is dissolved in the drug container 50 by the mixed solution, and a drug solution is generated. Subsequently, the chemical solution is sucked into the syringe 70 and then injected into the mixed solution container 60. By repeating the above steps, even a powdery medicine can be mixed with a mixed solution, and a mixed chemical solution can be generated in the mixed solution container 60. In addition, after inhaling the liquid mixture from the liquid mixture container 60 into the syringe 70, the syringe 70 is attached to the syringe holding unit 20, and the liquid mixture in the syringe 70 is injected into the drug container 50 in this state, thereby allowing You may make it melt | dissolve a powder-form chemical | medical agent in a container 50 with a liquid mixture. This eliminates the need to suck the mixed liquid from the mixed liquid container 60 in the closed space S1.

<2. Second Embodiment>
<2-1. Configuration of mixing device>
Next, the mixing apparatus 101 according to the second embodiment will be described with reference to FIGS. Similar to the mixing apparatus 1 of the first embodiment, the mixing apparatus 101 is formed so as to be able to hold the syringe 70, the drug container 50, and the mixed liquid container 60, and the drug in the drug container 50 and the mixed liquid container 60 It is an apparatus used in order to mix the liquid mixture. In addition, about the syringe 70, the chemical | medical agent container 50, and the liquid mixture container 60, since it is the same as that of 1st Embodiment, description is abbreviate | omitted.

  As shown in FIG. 7, the mixing apparatus 101 includes a main body 110 formed in a columnar shape, and a syringe holding unit 120 disposed so as to close an opening formed on the upper surface of the main body 110. The body 110 and the syringe holder 120 form a closed space S11 (see FIG. 10). In other words, the main body part 110 and the syringe holding part 120 are wall members that partition the closed space S11 and the external space where the user performing the mixing work exists. The main body 110 is entirely transparent so that the user can visually recognize the closed space S11 from the outside during the mixing operation. In FIG. 7, a container body 111 and a lid part 112 of a main body part 110 to be described later are removed, and the closed space S <b> 11 is not established, but the lid part 112 of the main body part 110 is removed from the container body. By attaching to 111, closed space S11 may be formed. In the following description, the rotation axis of the main body 110 is A2, and the vertical direction of the paper surface of FIG. 7 along this axis A2 is referred to as “upper” and “lower”.

  In addition, the mixing apparatus 101 includes a drug container holding unit 130 that holds the drug container 50 and a liquid mixture container holding unit 140 that holds the liquid mixture container 60, as in the first embodiment. The medicine container holding unit 130 can hold a plurality of medicine containers 50 (maximum of five in this embodiment), and is accommodated in the closed space S11 of the main body 110 while holding the medicine container 50. On the other hand, the mixed liquid container holding unit 140 can hold one mixed liquid container 60. And the liquid mixture container 60 of the state hold | maintained at the liquid mixture container holding | maintenance part 140 is arrange | positioned in the state where the opening of the liquid mixture container 60 faced the closed space S11 side in the exterior of closed space S11. Accordingly, in this state, the needle 73 of the syringe 70 that can move in the closed space S <b> 11 can be inserted into the opening of the liquid mixture container 60.

  Hereinafter, each part will be described in detail. The main body 110 is formed of a material such as plastic, and includes a cylindrical cup-shaped container body 111 and a lid section 112 that closes the upper opening of the container body 111. The container body 111 has a substantially circular bottom surface portion 111a and a substantially cylindrical side surface portion 111b continuous to the bottom surface portion 111a, and the upper end of the container body 111 (that is, the surface facing the bottom surface portion 111a) is open. ing. Further, an opening C7 (see FIG. 10) for inserting the mixed liquid container 60 is formed in the bottom surface portion 111a of the container body 111, and this opening C7 is mixed from the closed space S11 side as will be described later. The liquid container holding part 140 is closed. On the other hand, the lid portion 112 has an upper surface portion 112a having substantially the same size and shape as the bottom surface portion 111a of the container body 111, and a substantially cylindrical side surface portion 112b continuous to the upper surface portion 112a. (That is, the surface facing the upper surface portion 112a) is open.

  Then, the upper portion of the side surface portion 111 b of the container body 111 enters the inside of the side surface portion 112 b of the lid portion 112, whereby the opening of the container body 111 is closed by the lid portion 112. In the state where the lid portion 112 covers the container body 111, there is no gap between the upper outer peripheral surface of the side surface portion 111b of the container body 111 and the inner peripheral surface of the side surface portion 112b of the lid portion 112. Accordingly, the airtightness of the closed space S11 is maintained with respect to the external space. However, the lid portion 112 can be slidably rotated with respect to the container body 111 around the axis A2. At this time, the user can easily hold the lid 112 against the container body 111 by pinching the knob 112c formed on the upper surface 112a of the lid 112 and in the vicinity of the center to apply a force in the rotational direction. Can be rotated. In addition, as a method of configuring the lid portion 112 to be rotatable with respect to the container body 111 while maintaining the hermeticity of the closed space S11, the outer peripheral surface of the upper portion of the side surface portion 111b of the container body 111 and the side surface portion of the lid portion 112 are used. Any known method can be employed by those skilled in the art, such as coating the inner peripheral surface of 112b with a silicon coating or installing a packing.

  The syringe holding part 120 is disposed so as to close the opening formed in the upper surface part 112 a of the lid part 112. And by having the bellows structure similar to 1st Embodiment, it can deform | transform flexibly and can shrink | contract and expand freely up and down, right and left, and diagonally. Moreover, the syringe 70 can be hold | maintained by receiving the needle 73 of the syringe 70 with the upper end surface 120a. As shown in FIG. 8, the syringe holding part 120 is substantially circular in a plan view, and the center thereof is arranged at a position that is separated from the center of the lid part 112 of the main body part 110 by a distance D1 in the radial direction. .

  The medicine container holding part 130 is a disk-shaped member having substantially the same size and shape as the bottom surface part 111a of the container body 111, and is accommodated in the closed space S11. More precisely, the medicine container holding part 130 is disposed in the container body 111 in the vicinity of the center in the vertical direction of the container body 111 so as to be substantially parallel to the bottom surface part 111a of the container body 111. However, the medicine container holding part 130 is detachable from the container body 111. In addition, as a method of configuring the container body 111 and the drug container holding portion 130 so as to be separable and fixable, a plurality of them are provided at approximately equal intervals along the circumferential direction in the vicinity of the substantially vertical center of the inner peripheral surface of the container body 111. Any known method can be adopted by those skilled in the art, such as forming the protrusions of the medicine container so that the drug container holding part 130 is supported by the protrusions from below.

  As shown in FIG. 9, the drug container holding part 130 has six substantially circular openings, that is, first to sixth openings C <b> 1 to C <b> 6. The first opening C1 is a through hole through which the mixed liquid container holding part 140 passes from below. On the other hand, the remaining openings C2 to C6 are holes through which the bottle stopper 52 of the medicine container 50 passes from below. The second to sixth openings C2 to C6 are all the same size, have a radius that is smaller than the first opening C1 and slightly smaller than the bottle stopper 52 of the medicine container 50. Moreover, the medicine container holding part 130 can be formed of plastic having elasticity and flexibility. Therefore, the user can cause the bottle stopper 52 to pass through the openings C <b> 2 to C <b> 6 while lightly pulling or bending the medicine container holding part 130. And after inserting the bottle stopper 52 in the 2nd-6th opening C2-C6, the neck part 50a between the bottle stopper 52 and the shoulder part 50b will be in the state caught in each opening C2-C6, and the chemical | medical agent container 50 Is held in the medicine container holding part 130.

  As shown in FIG. 9, the first to sixth openings C <b> 1 to C <b> 6 of the drug container holding part 130 are arranged at equal intervals along the circumferential direction of the drug container holding part 130 in a plan view, and each center Is disposed at a position away from the center of the medicine container holding part 130 by a distance D1 in the radial direction. Therefore, when the lid 112 is rotated with respect to the container body 111 with the lid 112 covering the container body 111, the center of the syringe holding part 120 overlaps the center of the openings C1 to C6 in plan view. Moving. As a result, the needle 73 of the syringe 70 pierced near the center of the upper end surface 120a of the syringe holding part 120 can easily access the vicinity of the center of the bottle stopper of the drug container 50 and the mixed solution container 60.

  The mixed liquid container holding part 140 is made of an elastic material such as rubber or elastomer. As shown in FIG. 10, the container part 141 is formed in a cup shape that opens downward, and is disposed in the container part 141. And a crimping portion 142 to be used. The accommodating part 141 is attached to the main body part 110 so as to airtightly close the opening C7 formed in the bottom surface part 111a of the main body part 110. More specifically, the lower end edge of the accommodating portion 141 is fixed to the periphery of the opening C7, so that the accommodating portion 141 can form a recess in the bottom surface portion 111a of the main body 110 and can insert the mixed liquid container 60 therein. It functions as a wall which partitions off enclosed space S11 and the exterior. Moreover, the upper end part of the accommodating part 141 is inserted into the 1st opening C1 of the chemical | medical agent container holding part 130 from the downward direction as mentioned above. The crimping part 142 is formed in a cup shape that opens downward, and is press-fitted into the housing part 141. The inner diameter of the opening of the crimping part 142 is substantially the same as that of the bottle stopper 62 of the mixed liquid container 60. By inserting the bottle stopper 62 into the opening of the crimping part 142 from below, the bottle stopper 62 is an elastic body. The mixed solution container 60 is held by the mixed solution container holding unit 140 by being firmly crimped to the portion 142.

<2-2. Mixing method using mixing device>
Next, the flow of the mixing operation of the medicine and the mixed solution using the mixing device 101 and the syringe 70 will be described in detail with reference to FIG. Here, the medicine in the medicine container 50 is assumed to be a liquid unless otherwise specified.

  First, the user prepares the mixing device 101, the medicine container 50, the mixed liquid container 60, and the syringe 70. Next, the user removes the lid portion 112 of the main body portion 110 of the mixing device 101 and hooks the neck portion 51a of each drug container 50 into the second to fifth openings C2 to C5 of the drug container holding portion 130. Each drug container 50 is held with respect to the drug container holding unit 130. When the fixing operation is finished, the medicine container holding part 130 and the container body 111 are fixed, and the container body 111 is covered with the lid part 112, so that the medicine container 50 is confined in the closed space S11. By this step, the opening of each medicine container 50 is in a state where it can communicate with the closed space S11 via the needle 73 of the syringe 70 that is subsequently pierced through the bottle stopper 52 of the medicine container 50.

  Subsequently, the user inserts the mixed liquid container 60 into the concave portion of the mixed liquid container holding part 140 from below, and inserts the bottle stopper 62 of the mixed liquid container 60 into the crimping part 142, whereby the entire mixed liquid container 60 is removed. It holds with respect to the liquid mixture container holding part 140. Thereby, the opening of the liquid mixture container 60 is in a state where it can communicate with the closed space S11 through the needle 73 of the syringe 70 that is subsequently pierced through the bottle stopper 62 of the liquid mixture container 60.

  Subsequently, as shown in FIG. 10A, the user pierces the needle 73 of the syringe 70 near the center of the upper end surface 120 a of the syringe holding unit 120, so that the entire syringe 70 is moved to the syringe holding unit 120. Hold against. The needle 73 of the syringe 70 is pierced substantially perpendicularly from the outside to the inside of the closed space S11 with respect to the thin upper end surface 120a of the syringe holding unit 120. As a result, the closed space S11 is in communication with the needle 73 of the syringe 70 and eventually the internal space S2 of the syringe 70 via the internal flow passage.

  Subsequently, a mixing operation of the drug and the mixed solution is performed. First, the user rotates the lid portion 112 to position the syringe holding portion 120 above the desired medicine container 50. Subsequently, the needle 73 of the syringe 70 is lowered with respect to the bottle stopper 52 of the medicine container 50 in the closed space S11. 10B, the internal space S2 of the syringe 70 is communicated with the internal space of the medicine container 50 via the needle 73 of the syringe 70 by piercing the thin portion of the bottle stopper 52. Since the syringe holding part 120 has a bellows structure, it can be contracted in the vertical direction as described in the first embodiment. For example, by pushing the syringe holding part 120 downward, the syringe holding part 120 can enter the opening of the lid part 112 of the main body part 110 and protrude into the closed space S11.

  In this state, the user draws the medicine in the medicine container 50 into the internal space S2 by pulling the piston 72 of the syringe 70 in the direction of pulling out the piston 72 from the internal space S2 of the cylinder 71. Thereafter, the user pulls out the needle 73 of the syringe 70 from the bottle stopper 52 of the medicine container 50 by pulling up the syringe holding part 120 having the bellows structure upward.

  Subsequently, the user rotates the lid portion 112 and positions the syringe holding portion 120 so as to be disposed above the mixed solution container 60. Then, as shown in FIG. 10C, the needle 73 of the syringe 70 is lowered with respect to the mixed solution container 60 in the closed space S11, and the accommodation portion 141 of the mixed solution container holding unit 140 and the crimping are performed with the needle 73 of the syringe 70. The thin part of the bottle stopper 62 of the part 142 and the liquid mixture container 60 is pierced. Thus, the internal space S2 of the syringe 70 is communicated with the internal space of the mixed liquid container 60 via the needle 73 of the syringe 70. At this time, the needle 73 of the syringe 70 is pierced substantially perpendicularly from the inside of the closed space S11 to the inside of the mixed liquid container 60 with respect to the thin portion of the bottle stopper 62.

  In this state, the user pushes the piston 72 of the syringe 70 into the internal space S <b> 2 of the cylinder 71 to inject the medicine in the internal space S <b> 2 into the mixed solution container 60. Thereafter, the user pulls up the syringe 70 upward, thereby pulling out the needle 73 of the syringe 70 from the bottle stopper 62 of the mixed liquid container 60 and the accommodating part 141 and the crimping part 142 of the mixed liquid container holding part 140.

  By repeating the above steps as many times as necessary, a mixed drug solution in which the drug and the mixed solution are mixed in the mixed solution container 60 is generated. That is, as shown in FIG. 10D, the medicines in other medicine containers 50 are also sucked by the syringe 70 and then injected into the mixed liquid container 60 as necessary. When the mixing of the medicine is completed in this way, the user removes the mixed liquid container 60 from the mixed liquid container holding part 140 by strongly pulling it downward while turning the mixed liquid container 60. Thereafter, the user carries the mixed liquid container 60 containing the mixed chemical liquid to the patient and administers the mixed chemical liquid in the mixed liquid container 60 to the patient by a method such as instillation.

  Finally, the user discards the mixing device 101, the medicine container 50, and the syringe 70 while holding the medicine container 50 and the syringe 70 with respect to the mixing device 101. That is, the medicine container 50 and the syringe 70 are discarded while being integrated with the mixing apparatus 101 without being removed from the mixing apparatus 101. At this time, the lid portion 112 keeps the lid of the container body 111, and the piston 72 of the syringe 70 remains inserted into the cylinder 71, so that the closed space S11 and the internal space S2 of the cylinder 71 are exposed to the external space. Do not be.

  In addition, when a chemical | medical agent is a powdery form, mixing with a chemical | medical agent and a liquid mixture is possible by the method similar to 1st Embodiment.

<3. Third Embodiment>
<3-1. Configuration of mixing device>
Next, a mixing apparatus 201 according to the third embodiment will be described with reference to FIGS. 11 and 12. Similar to the mixing devices 1 and 101, the mixing device 201 is formed so as to be able to hold the syringe 70, the drug container 50, and the mixed solution container 60, and the drug in the drug container 50 and the mixed solution in the mixed solution container 60 It is an apparatus used for mixing. In addition, about the syringe 70, the chemical | medical agent container 50, and the liquid mixture container 60, it abbreviate | omits description as what is the same as that of 1st and 2nd embodiment.

  The third embodiment is different from the second embodiment in the aspect of the syringe holding unit 220. That is, in the second embodiment, the syringe holding unit 120 is rotating, whereas in the third embodiment, the syringe holding unit 220 moves on a straight line. Corresponding to this, the medicine container 50 and the mixed liquid container 60 are arranged side by side on a straight line.

  As shown in FIG. 11, the mixing apparatus 201 includes a rectangular parallelepiped main body 210 that defines a closed space S21. The main body 210 is entirely transparent so that the user can visually recognize the closed space S21 from the outside during the mixing operation. The main body 210 includes a plastic container body 211 having a substantially rectangular bottom surface portion 211a and a substantially rectangular tube-shaped side surface portion 211b continuous to the bottom surface portion 211a. The upper opening of the container 211 is closed by the lid 212. In addition, the up-down direction in this embodiment is a direction of arrow A3 of FIG. 11 which goes to the center of the cover part 212 from the center of the bottom face part 211a. In the following, the longitudinal direction of the lid part 210 indicated by the arrow A4 in FIG. 11 is referred to as the left-right direction, and the short side direction of the lid part 210 indicated by the arrow A5 in FIG.

  The lid 212 is formed with a linear slit 212a extending in the longitudinal direction near the center in the depth direction. A syringe holding part 220 that moves to the left and right along the slit 212a is attached to the lid part 212, and the parts that define the outlines of the syringe holding part 220 and the slit 212a of the lid part 212 are closed. Has a type of fastener structure. That is, as the syringe holding part 220 serving as a slider moves, the portion of the slit 212a corresponding to the path along which the syringe holding part 220 has moved is closed. Therefore, the airtightness of the closed space S <b> 21 is maintained with respect to the external space in a state where the lid 212 is closed with the container body 211. Moreover, the syringe holding part 220 is formed of an elastic material such as an elastomer, and can hold the cylinder of the syringe 70 in a state where the cylinder 71 of the syringe 70 penetrates. At this time, the syringe holding part 220 can move the syringe 70 in the vertical direction in a state where the closed space S21 is held airtight while being crimped to the syringe 70.

  Further, a through hole D1 (see FIG. 12) is formed in a longitudinal end portion (right side in FIG. 11) in the bottom surface portion 211a of the container body 211 of the main body 210, and the through hole D1 is closed. The liquid mixture container holding part 240 is arranged. A drug container holding unit 230 is arranged on the left side of the mixed liquid container holding unit 240. The medicine container holding unit 230 can hold a plurality of medicine containers 50, and the configuration thereof is substantially the same as in the second embodiment. That is, it is formed of the same plate-like material as in the second embodiment, and the openings for holding the medicine container 50 are arranged in a straight line. That is, three substantially circular openings C21 to C23 arranged in the longitudinal direction are formed immediately below the slit 212a of the lid 212 in the main body 210.

  The configuration of the mixed liquid container holding unit 240 is the same as that of the second embodiment, and is different in that the shape is mainly a square tube. That is, the bottle stopper 62 of the mixed liquid container 60 formed of an elastic material such as rubber or elastomer and inserted from the through hole D1 of the bottom surface portion 211a of the main body 210 is crimped. Thereby, the liquid mixture container 60 is held in the liquid mixture container holding part 240.

<3-2. Mixing method using mixing device>
Hereinafter, the flow of the mixing operation of the medicine and the liquid mixture using the mixing device 201 and the syringe 70 will be described in detail with reference to FIG. Here, the medicine in the medicine container 50 is assumed to be a liquid unless otherwise specified.

  First, the user prepares the mixing device 201, the medicine container 50, the mixed liquid container 60, and the syringe 70. Subsequently, as in the second embodiment, the medicine container 50 and the mixed solution container 60 are attached to the mixing device 201, and the syringe 70 is attached to the syringe holding unit 220. Subsequently, the user places the needle 73 of the syringe 70 above any one of the drug containers 50 in the closed space S21. That is, the syringe 70 is positioned above the desired medicine container 50 by linearly moving along the slit 212a in the longitudinal direction together with the syringe holding part 220. From this state, the syringe 70 is lowered, and the needle 73 is pierced through the thin portion of the bottle stopper 52 of the drug container 50, so that the internal space S <b> 2 of the syringe 70 passes through the needle 73 of the syringe 70. It communicates with the space (see FIG. 12B). Subsequently, the medicine in the medicine container 50 is sucked into the internal space S2 by pulling the piston 72 of the syringe 70 in the direction in which the piston 72 is pulled out from the internal space S2 of the cylinder 71. Thereafter, the user pulls the syringe 70 upward and pulls out the needle 73 from the bottle stopper 52 of the medicine container 50.

  Following this, the user linearly moves the syringe 70 together with the syringe holding part 220 to the end in the longitudinal direction along the slit 212a. That is, the needle 73 of the syringe 70 is positioned above the liquid mixture container 60 in the closed space S21. From this state, the syringe 70 is lowered, and the mixed liquid container holding part 240 and the bottle stopper 62 are pierced by the needle 73, so that the internal space S2 of the syringe 70 is passed through the needle 73 of the syringe 70. It communicates with the internal space (see FIG. 12C). Subsequently, the user pushes the piston 72 of the syringe 70 into the internal space S <b> 2 of the cylinder 71, thereby injecting the medicine in the internal space S <b> 2 of the syringe 70 into the mixed liquid container 60. Thereafter, the user pulls the syringe 70 upward, and pulls out the needle 73 from the bottle stopper 62 of the mixed liquid container 60 and the mixed liquid container holding part 240.

  By repeating the above steps for a plurality of drug containers 50 as many times as necessary, a mixed drug solution in which the drug and the mixed solution are mixed in the mixed solution container 60 is generated. That is, the mixed solution container 60 containing the mixed drug solution is generated in a state where the drug exposure does not reach the outside of the closed space S21. Accordingly, it is possible to prepare a safe mixed solution container 60 containing a mixed chemical solution, which is used for administering a drug to a patient. The process according to the third embodiment is suitable for automation by a machine because the movement of the syringe 70 is linear. As an automation method, a known technique such as connecting a control unit or the like capable of executing a program for controlling an up / down / left / right oblique operation of the syringe 70 to the syringe holding unit 220 may be appropriately used. In addition, it cannot be overemphasized that operation | movement of the syringe 70 which concerns on other embodiment, especially rotation movement of the syringe 70 which concerns on 2nd Embodiment can also be automated by a well-known technique.

  Subsequently, the user removes the mixed liquid container 60 from the mixed liquid container holding part 240 and carries the mixed liquid container 60 to the patient. Further, the mixing device 201 from which the mixed solution container 60 has been removed is discarded while holding the medicine container 50 and the syringe 70. The mixing method when the drug is powdery is the same as in the first and second embodiments.

<4. Fourth Embodiment>
<4-1. Configuration of mixing device>
Next, a mixing apparatus 301 according to the fourth embodiment will be described with reference to FIGS. 13 and 14. The mixing device 301 is formed so as to be able to hold the syringe 70, the drug container 50 and the mixed solution container 60 in the same manner as the mixing devices 1, 101 and 201 of the above embodiment, and the drug in the drug container 50 and the mixed solution container 60 is an instrument used to mix the liquid mixture in 60. In addition, about the syringe 70, the chemical | medical agent container 50, and the liquid mixture container 60, it abbreviate | omits description as what is the same as that of 1st to 3rd embodiment.

  The mixing device 301 according to this embodiment is different from the other embodiments mainly in that the medicine container 50 is continuously connected to the closed space S31. Below, it demonstrates centering on this structure, and abbreviate | omits description the same structure as other embodiment.

  First, the main body 313 will be described. As shown in FIG. 13, the main body 313 is formed of a transparent box-shaped material having a closed space S <b> 31 inside, and is supported by the base frame 311. Accordingly, a space is formed below the main body 313, and the mixed liquid container 60 is disposed in this space as will be described later. On the upper surface of the main body 313, a syringe holding part 320 similar to that in the first and second embodiments is arranged. On the other hand, an opening is formed on the bottom surface of the main body 313, and a closing member 314 made of an elastic material such as rubber or elastomer is disposed so as to close the opening. In addition, an opening 315 for communicating the inside of the medicine container 50 and the closed space S31 is formed on the side surface of the main body 313.

  The base frame 311 is provided with a medicine container holding portion 330 that holds the medicine container 50. The drug container holding unit 330 includes an inclined surface 312 inclined downward from the upper part of the base frame 311, and a plurality of drug containers 50 stacked while being inclined are accommodated in the inclined surface 312. The bottle stopper 52 of the medicine container 50 arranged at the lower end of the inclined surface 312 is arranged to face the opening 315 of the main body 313. As will be described later, when the medicine container 50 from which the medicine has been extracted, that is, the medicine container 50 arranged at the lower end of the inclined surface 312 is removed, the stacked medicine containers 50 descend in order, and It arrange | positions so that the opening 315 may be opposed. In the base frame 311, a disposal space 316 is provided below the inclined surface 312 to store the used medicine container 50 after the medicine is extracted.

  In the base frame 311, a mixed liquid container holding part 340 that engages with the neck part 61 a of the mixed liquid container 60 is attached below the main body part 313, and the mixed liquid container 60 is connected to the mixed liquid container holding part 340. The bottle stopper 62 of the mixed solution container 60 is arranged immediately below the closing member 314.

  The syringe holding part 320 of the present embodiment can hold the syringe 70 by receiving the cylinder 71 of the syringe 70 at its upper end surface 320a. More specifically, an opening having substantially the same size and shape as the cross-sectional shape of the cylinder 71 in the longitudinal direction is formed in the upper end surface 320a of the syringe holding part 320. An anti-slip member 321 is fixed on the upper end surface 320a of the syringe holding part 320, and the anti-slip member 321 has an opening having substantially the same size and shape as the opening of the upper end face 320a of the syringe holding part 320. Is formed. These openings formed in the upper end surface 320a of the syringe holding part 320 and the anti-slip member 321 are aligned with each other. Then, the needle 73 and the cylinder 71 of the syringe 70 can be inserted into the closed space S31 through these openings. The anti-slip member 321 is an elastomeric member having elasticity and flexibility. The anti-slip member 321 is pressed against the cylinder 71 inserted into the opening of the anti-slip member 321 so that the cylinder 71 does not intentionally slide in the longitudinal direction. Play a role to prevent. A similar configuration may be provided in the first to third embodiments described above.

<4-2. Mixing method using mixing device>
Hereinafter, the mixing method by the mixing apparatus 301 of this embodiment is demonstrated, referring FIG. Here, the medicine in the medicine container 50 is assumed to be a liquid unless otherwise specified.

  First, the user arranges a plurality of drug containers 50 in an inclined state and holds them in the drug container holding unit 330. At this time, the bottom surface of the medicine container 50 is inclined with respect to the horizontal direction and the vertical direction. Therefore, even if the liquid in the medicine container 50 is sucked by the syringe 70 and the amount of the medicine remaining in the medicine container 50 is reduced, the remaining medicine is collected near the edge of the bottom surface of the tilted medicine container 50. As a result, the medicine in the medicine container 50 can be easily sucked into the internal space S2 of the syringe 70 to the end. Next, the user holds the mixed liquid container 60 against the mixed liquid container holding part 340 by engaging the bottle stopper 62 of the mixed liquid container 60 with the mixed liquid container holding part 340.

  Subsequently, as shown in FIG. 13, the user passes the needle 73 and the cylinder 71 of the syringe 70 through the opening formed in the upper end surface 320 a of the syringe holding unit 320 and the anti-slip member 321, thereby moving the entire syringe 70. Hold against the syringe holder 320. Following this, the user moves the needle 73 of the syringe 70 to the opening 315 in the closed space S31 and pierces the bottle stopper 52 of the lowermost drug container 50 as shown in FIG. 14 (a). . Thereby, the internal space S <b> 2 of the syringe 70 is communicated with the internal space of the lowermost drug container 50 via the needle 73 of the syringe 70. At this time, the needle 73 of the syringe 70 is pierced substantially perpendicularly from the outside of the drug container 50 to the inside of the drug container 50 with respect to the thin portion of the bottle stopper 52.

  Next, the user sucks the medicine in the medicine container 50 with the syringe 70, and then pulls the needle 73 of the syringe 70 from the bottle stopper 52 of the medicine container 50 by pulling the syringe 70 together with the syringe holding part 320. Subsequently, the user moves the needle 73 of the syringe 70 to the closing member 314 in the closed space S31, and, as shown in FIG. 14B, the closing member 314 and the bottle of the mixed liquid container 60 facing the closing member 314. The stopper 62 is pierced. Thus, the internal space S2 of the syringe 70 is communicated with the internal space of the mixed liquid container 60 via the needle 73 of the syringe 70. Subsequently, the medicine in the internal space S <b> 2 of the syringe 70 is injected into the mixed solution container 60. Thereafter, the user pulls out the needle 73 of the syringe 70 from the bottle stopper 62 and the closing member 314 of the mixed liquid container 60. In the above process, since the closure member 314 and the bottle stoppers 52 and 62 of the containers 50 and 60 are formed of an elastic material, even if the needle 73 of the pierced syringe 70 is pulled out, it is formed by the needle. The hole is naturally closed. Therefore, the drug is not exposed from the containers 50 and 60 and the main body 313.

  When mixing of the medicine in the first medicine container 50 is completed in this manner, the inclination angle of the inclined surface 312 is changed via a mechanism (not shown), and only the lowermost medicine container 50 is removed from the inclined surface 312, and is disposed in the disposal space 316. Drop it. As a mechanism for changing the inclination angle of the inclined surface 312, for example, while urging the drug container holding portion 330 to the position shown in FIGS. 13 and 14, the needle tip of the syringe 70 or the like is used in FIGS. 13 and 14. When the button is pushed leftward, a mechanism for rotating the drug container holding part 330 around an axis near the upper end thereof is conceivable. Along with this, the stacked medicine containers 50 descend on the inclined surface 312 and the bottle stopper 52 of the next medicine container 50 is arranged to face the opening 315 of the main body 313. In this state, as described above, the medicine is extracted and injected into the mixed solution container. As described above, by mixing the drug as many times as necessary, a mixed drug solution in which the drug and the mixed solution are mixed in the mixed solution container 60 is generated. That is, the mixed solution container 60 containing the mixed drug solution is generated in a state where the drug exposure does not reach the outside of the closed space S31. Accordingly, it is possible to prepare a safe mixed solution container 60 containing a mixed chemical solution, which is used for administering a drug to a patient.

  Subsequently, as shown in FIG. 14C, the user removes the mixed solution container 60 from the mixed solution container holding unit 340. Thereafter, the user carries the mixed liquid container 60 containing the mixed chemical liquid to the patient and administers the mixed chemical liquid in the mixed liquid container 60 to the patient by a method such as instillation. Following this, the mixing device 301, drug container 50 and syringe 70 are discarded while the drug container 50 and syringe 70 are held. In addition, when a chemical | medical agent is powdery, the process similar to the said embodiment is performed.

<5. Fifth Embodiment>
<5-1. Configuration of mixing support device>
Next, the mixing support apparatus 2 according to the fifth embodiment will be described with reference to FIGS. 15 to 18. This mixing support apparatus 2 is an apparatus for supporting a mixing operation using the mixing apparatus 101 of the second embodiment. Unless otherwise specified, the syringe 70, the drug container 50, and the mixed solution container 60 are the same as those in the first to fourth embodiments, and the mixing device 101 is the same as that in the second embodiment. .

  As shown in FIG. 15, the mixing support apparatus 2 can support the mixing apparatus 101. 15 shows the mixing support apparatus 2 in a state where the mixing apparatus 101 is supported. In particular, FIG. 15A is a cross-sectional view seen from the front side passing through the center of the mixing apparatus 101. 15 (b) is a cross-sectional view seen from the left side surface that similarly passes through the center of the mixing apparatus 101. However, for easy understanding, the front view of the mixing device 101 and the syringe 70, the medicine container 50, and the mixed solution container 60 held by the mixing device 101 except for the knob portion 112 c of the lid portion 112 of the mixing device 101. And a side view. 17 and 18 are the same as FIG. 15A.

  As illustrated in FIG. 15, the mixing support device 2 includes an orientation changing mechanism 510 that changes the orientation of the mixing device 101 and a base plate 520 that supports the orientation changing mechanism 510. The orientation changing mechanism 510 includes a support column 511 extending substantially up and down from the base plate 520, a shaft 512 that moves up and down substantially along substantially the upper half of the support column 511, and a lift mechanism 513 that realizes the lifting and lowering of the shaft 512. Have The shaft 512 has a substantially cylindrical shape, and protrudes from the support column 511 to the front side at an angle substantially perpendicular to the support column 511. The elevating mechanism 513 is engaged with the slide rail 513a that is fixed so as to extend substantially vertically on the substantially upper half of the front side of the support column 511, and the slider 513b that slides freely along the slide rail 513a. And have. The slider 513b can be stationary at an arbitrary position in the slide rail 513a. Similarly to the shaft 512, the slider 513b has a substantially cylindrical shape, and is inserted into an opening formed inside the shaft 512 so that the shaft 512 and the central axis overlap. Therefore, the shaft 512 is supported by the slider 513b, and as a result, the shaft 512 is also translated in the substantially vertical direction as the slider 513b slides in the generally vertical direction. Further, there is moderate play between the slider 513b and the shaft 512, and the user can manually rotate the shaft 512 around the slider 513b.

  The mixing support device 2 further includes a bearing 514 that receives a shaft 512 penetrating the inside, and a space 514 a that receives the knob portion 112 c of the lid portion 112 of the mixing device 101 is formed at a lower portion of the bearing 514. . In the present embodiment, the knob portion 112c has a shape in which a substantially disk-shaped member that is slightly larger than this in a plan view is continuous with the upper surface of the substantially cylindrical member. As a result, when the knob portion 112c is inserted into the space 514a, the entire mixing apparatus 101 is supported from above by the bearing 514 so that it does not fall off from the bearing 514. The space 514a is defined by a main body 514b of the bearing 514 and a cover 514c that is detachable with respect to the lower portion on the front side thereof, and the space 514a can be opened and closed by attaching and detaching the cover 514c. As a result, the mixing apparatus 101 is detachable from the bearing 514.

  Then, there is no play between the shaft 512 and the bearing 514, and when the user rotates the shaft 512 with respect to the slider 513b, the bearing 514 also rotates as shown in FIG. Further, the mixing device 101 supported by the bearing 514, and the syringe 70, the medicine container 50, and the mixed solution container 60 held by the mixing device 101 also rotate simultaneously. That is, the user changes the orientation of the mixing apparatus 101 in a state in which the syringe 70, the drug container 50, and the mixed solution container 60 are held by the direction changing mechanism 501, so that the syringe 70, the drug container 50, and the mixed solution container 60 The direction can be changed. Therefore, it becomes easy to arrange the medicine container 50 and the liquid mixture container 60 directly above or obliquely above the syringe 70 and to allow the syringe 70 to access the inside of the medicine container 50 and the liquid mixture container 60 from directly below or obliquely below. As a result, the liquid in the medicine container 50 and the mixed liquid container 60 can be easily sucked into the syringe.

  The mixing support device 2 further includes a support member 515 that is disposed on the base plate 520 and supports the mixing device 101 from below. Here, in the present embodiment, as shown in FIG. 16, a substantially square recess 111 c is formed in the vicinity of the substantially center of the bottom surface of the bottom surface portion 111 a of the mixing apparatus 101. 16A is a bottom view of the bottom surface portion 111a, FIG. 16B is a side sectional view of the bottom surface portion 111a, and FIG. 16C is a side view of the support member 515. The relative size with respect to the recess 111c is shown. The support member 515 has a substantially rectangular parallelepiped shape, and this concave portion is in a state where the mixing device 101 supported by the bearing 514 is aligned at the bottom by the lifting mechanism 513 (hereinafter referred to as a locked state). Fits into 111c. As a result, in the locked state, even if the user tries to rotate the mixing device 101 connected to the shaft 512, the rotation is blocked by the support member 515.

  By the way, there is moderate play between the bearing 514 and the knob portion 112c, and the user can manually rotate the knob portion 112c with respect to the bearing 514 in the space 514a. At this time, in the locked state, the rotation of the container body 111 of the mixing apparatus 101 in the horizontal plane is obstructed by the support member 515, and the lid portion 112 of the mixing apparatus 101 rotates with respect to the bearing 514 and the container body 111. Accordingly, the syringe holding unit 120 whose position is fixed with respect to the lid part 112 is also relative to the container body 111, and thus the drug container holding unit 130 and the mixed solution container holding part 140 whose position is fixed to the container body 111. Rotate. That is, the user relatively moves the needle 73 of the syringe 70 held by the syringe holding unit 120 between the drug container 50 and the mixed solution container 60 in the closed space S11 by the bearing 514 and the support member 515. Can be made. Therefore, the needle 73 of the syringe 70 can easily access the inside of the medicine container 50 and the mixed liquid container 60.

<5-2. Mixing support apparatus and mixing method using mixing apparatus>
Hereinafter, a mixing method using the mixing support apparatus 2 and the mixing apparatus 101 of the present embodiment will be described with reference to FIGS. 15, 17, and 18. In addition, since the mixing method of this embodiment has many parts which overlap with the mixing method of 2nd Embodiment, below, it demonstrates centering on the difference with 2nd Embodiment.

  First, the user performs preparatory work for fixing the drug container 50, the mixed solution container 60, and the syringe 70 to the mixing apparatus 101 as in the second embodiment. Thereafter, the knob portion 112c of the mixing device 101 is housed in the space 514a of the bearing 514 of the mixing support device 2, and the height of the mixing device 101 is adjusted by the elevating mechanism 513 to be in the locked state.

  Subsequently, the user rotates the lid 112 around the knob 112c, positions the syringe 70 above the desired drug container 50, and pierces the bottle stopper 52 of the drug container 50 with the needle 73 of the syringe 70 ( FIG. 15). Thereafter, the mixing device 101, the liquid mixture container 60, the medicine container 50, and the syringe 70 (hereinafter referred to as the mixing device 101 and the like) held by the mixing device 101 are slid upward and fixed by the lifting mechanism 513 (see FIG. 17 (a)), the locked state is released. Then, the mixing apparatus 101 or the like is rotated by 180 ° around the axis 512, and the mixing apparatus 101 or the like is turned upside down from the state of FIG. In this state, the drug is extracted from the drug container 50 to the internal space S2 of the syringe 70 by pulling the piston 72 of the syringe 70 from the cylinder 71 (see FIG. 17B). Thereafter, the mixing device 101 and the like are further rotated by 180 ° around the shaft 512, and the needle 73 is again returned to the downward direction. In addition, the mixing device 101 and the like are slid downward and fixed by the lifting mechanism 513 and locked. (See FIG. 18A). Subsequently, in order to inject the medicine in the syringe 70 into the mixed solution container 60, the needle 73 is pulled out from the medicine container 50, the lid portion 112 is rotated around the knob portion 112c, and the syringe 70 is positioned above the mixed solution container 60. (See FIG. 18B). Then, the bottle stopper 62 is pierced with the needle 73 and the piston 72 is pushed into the cylinder 71 to inject the medicine in the syringe 70 into the mixed solution container 60. Thereafter, the needle 73 is pulled out from the bottle stopper 62.

  Then, when the above steps are repeated for the required number of drug containers 50, a safe mixed liquid container 60 containing a mixed chemical liquid without worrying about external drug contamination is generated. Subsequently, the mixed solution container 60 is detached from the mixed solution container holding unit 140 and used for treatment of the patient. On the other hand, the user removes the mixing device 101 holding the drug container 50 and the syringe 70 from the bearing 514 of the mixing support device 2, and discards the drug container 50, the syringe 70 and the mixing device 101 as a single unit. Therefore, as in the second embodiment, the drug confined in the closed space S11 and the internal space S2 of the cylinder 71 is not exposed to the external space.

  Here, the drug in the drug container 50 has been described as a liquid. However, when the drug is in a powder form, the drug container 50 and the mixed liquid container are used with the syringe 70 as in the second embodiment. What is necessary is just to change the order to access 60 suitably.

<6. Features>
<6-1>
In the first to fifth embodiments, it is possible to reliably perform the mixing operation of the cytotoxic drug and the mixed liquid in the closed space, and prevent the drug from leaking to the outside. Therefore, for example, it becomes possible for a pharmacist to dispense at home, or for a patient to take care at home, and the mental and economic burden on the user can be reduced. In addition, with the device as in the above-described embodiment, it is possible to easily and reliably expose a drug with a disposable instrument (mixing device) that is small and inexpensive and can be used without using a large and expensive device. Can be prevented.

<6-2>
In the first and fourth embodiments, the bottom surface of the drug container 50 is inclined with respect to the vertical direction during normal use of the mixing apparatus, that is, the direction in which the needle 73 of the syringe 70 accesses the inside of the mixed liquid container 60. Therefore, even if the amount of liquid remaining in the container 50 is reduced, the remaining liquid is collected near the edge of the bottom surface of the inclined container 50. As a result, the liquid in the medicine container 50 can be easily sucked into the syringe 70. Further, even if the medicine container 50 is separated from the syringe 70, the needle 73 of the syringe 70 can be arranged substantially perpendicularly with respect to the bottle stopper 52 of the medicine container 50 simply by tilting the syringe 70. If the 70 is moved, the medicine container 50 can be accessed. Therefore, the needle 73 of the syringe 70 can be accessed to the medicine container 50 without largely moving the syringe holding part.

<7. Modification>
As mentioned above, although several embodiment of this invention was described, this invention is not limited to the said embodiment, A various change is possible unless it deviates from the meaning. For example, the following changes can be made.

<7-1>
The number of the drug containers 50 that can be simultaneously held by the drug container holding part may be one, or the number of the mixed liquid containers 60 that can be simultaneously held by the mixed liquid container holding part may be two or more. Good.
<7-2>
If the internal space S2 of the syringe 70 is accessible to the drug container 50 and the mixed solution container 60 through the closed space, the syringe 70 without the needle 73 may be used for the mixing operation.

<7-3>
The part of the mixing device that is formed to be transparent so that the closed space is visible from the outside is not limited to that described above. For example, only a part of the main body part may be transparent in a manner like a viewing window, and the closed space is visually recognized from the outside among the main body part, the syringe holding part, the drug container holding part, and the mixed liquid container holding part. Any part suitable for the above may be made transparent.

<7-4>
The main body part and the syringe holding part are integrally formed, and the boundary between the two may not be distinguishable or may not be formed integrally. In addition, in the case where the main body unit and the syringe holding unit are integrated, a case where the two are not distinguished until the user stabs the needle is included. That is, there is a member that defines a closed space, and among the members, the peripheral portion of the portion where the user stabbed the needle becomes the syringe holding portion, and the other portion may become the main body portion.

<7-5>
Variations can be made to the drug container holding portion so as to accommodate drug containers 50 of various sizes. It is also possible to prepare various sizes of mixing devices such as large size and small size, and select and use an appropriate size mixing device according to the size of the drug container 50 to be mixed. It is. The same applies to the mixed liquid container holding part.

<7-6>
The needle 73 is guided to at least one of the bottle stopper 52 of the medicine container 50 and the bottle stopper 62 of the mixture container 60 so that the medicine can be safely taken out from the medicine container 50 and the medicine and the mixture can be mixed safely. A guide plate may be provided.
Specifically, for example, a mode in which a guide plate 80 as shown in FIG. 19 is provided in the mixing apparatus 1 according to the first embodiment is conceivable. FIG. 19A is a side view of the mixing apparatus 1 in a state where the medicine container 50 and the mixed solution container 60 are held, and FIG. 19B is a plan view of the guide plate 80. Here, in FIG. 19B, the positions of the bottle stoppers 52 and 62 are indicated by dotted lines for reference. The guide plate 80 is formed with a slit 80 a for guiding the needle 73 to the vicinity of the center of the bottle stoppers 52 and 62. The slit 80a has a shape in which three straight lines having the same length intersect each other at the center at intervals of 60 ° in plan view, and the intersection is approximately at the center of the mixed liquid container holding unit 40. Overlap. When the needle 73 is inserted vertically into the slit 80a in the vicinity of the intersection, the needle 73 penetrates near the center of the mixed liquid container holding part 40 and further penetrates near the center of the bottle stopper 62 of the mixed liquid container 60. Then, it reaches the internal space of the mixed liquid container 60.

On the other hand, locations corresponding to both ends of the three straight lines of the slit 80a substantially overlap with the center of the bottle stopper 52 of the medicine container 50 in plan view. Therefore, when the needle 73 is moved linearly along the slit 80a and is inserted vertically into the slit 80a at locations corresponding to both ends of the three straight lines, the needle 73 becomes the drug container holding portion. 30 passes through the vicinity of the center of 30 and further passes through the vicinity of the center of the bottle stopper 52 of the medicine container 50 to reach the internal space of the medicine container 50.
As described above, if the guide plate according to this modification is used, the needle 73 can be easily and accurately guided to the internal spaces of the drug container 50 and the mixed solution container 60.

<7-7>
A back-type liquid mixture container 60 made of polyolefin or the like may be a target for mixing with a drug.
<7-8>
The method of fixing the mixed liquid container 60 and the mixed liquid container holding unit 40 is not limited to the above-described method. For example, it may be a screw type.

<7-9>
The shape of the bottle stopper 62 of the mixed liquid container 60 differs depending on the mixed liquid container 60. Therefore, you may attach the attachment which adapts various shapes to a liquid mixture container holding | maintenance part. The same applies to the medicine container holding part.

<7-10>
A safety mechanism for preventing the needle 73 from piercing the mixed liquid container holding part unless the mixed liquid container 60 is connected to the mixed liquid container holding part, for example, only when the closing port of the mixed liquid container 60 is crimped to the mixed liquid container holding part. A shutter mechanism that opens may be provided.

<7-11>
Prevention of chemical liquid leakage between the mixed liquid container holding part and the mixed liquid container 60 is extremely important, and various known means can be added.
<7-12>
The mixing apparatus according to the present invention is not limited to the above-described drugs to be mixed, and can be mixed with all drugs that may be problematic to be exposed to the outside, such as drugs having odor or irritation. .

<7-13>
In order to ensure sterility, the needle 73 of the syringe 70 may be covered with a soft soft sheath 74 (see FIG. 20) that is elastically deformed. In this case, from the state shown in FIG. 20A in which the entire needle 73 is covered with the soft sheath 74, an object such as the bottle stopper 52 of the drug container 50 and the bottle stopper 62 of the mixed solution container 60 is pierced with the needle 73. Then, a state as shown in FIG. That is, the needle 73 also pierces the tip of the soft sheath 74 when piercing an object such as the bottle stoppers 52 and 62. At this time, the soft sheath 74 having flexibility is the root of the needle 73 of the cylinder 71. And an object such as the bottle stoppers 52 and 62. After that, when the needle 73 is pulled out from the object such as the bottle stoppers 52, 62, the elastic soft sheath 74 is released from the compressed state and returned to the original shape as shown in FIG. The whole is accommodated in the soft sheath 74 again. At this time, the opening at the tip of the soft sheath 74 formed by the puncture of the needle 73 is naturally blocked by the elasticity of the soft sheath 74.

<7-14>
As described a little in the first embodiment, not only the connecting mechanism between the syringe 70 and the syringe holding unit 20 (more precisely, the needle housed in the syringe holding unit 20), but also the syringe 70 and the syringe holding unit 120. , 220, 320 can also be a luer lock type. In general, a luer lock type syringe means that the tip of a cylinder and a needle or the like arranged at the tip of the cylinder are connected in a screw form. Here, an arbitrary part of the syringe 70 ( For example, a mechanism for similarly screwing a cylinder side surface and arbitrary portions of the syringe holding portions 120, 220, and 320 is also expressed as a luer lock type.

  The luer lock type screwing mechanism may be configured to rotate idly when a certain torque is applied. According to this configuration, even after the syringe 70 and the syringe holders 20, 120, 220, and 320 are firmly connected, the syringe 70 is held in the syringe holders 20, 120 without changing the fastening strength of the screws. , 220, 320 can be rotated. As a result, it is possible to easily align the scale printed along the longitudinal direction on a part of the circumferential direction of the cylinder 71 at an arbitrary position where the user can easily see. When the scale is automatically read by a sensor or the like, the scale can be easily directed to the detection surface of the sensor or the like. Further, by providing such an idling mechanism, it is possible to easily remove bubbles generated in the liquid inside the syringe 70. Specifically, the syringe 70 may be rotated idly in a state where the syringe 70 is substantially horizontal, so that bubbles can gather in the head space of the syringe 70 and be pushed out together.

<7-15>
The needle 73 may be a needle having two flow paths 73a and 73b inside as shown in FIG. 21 in order to facilitate the suction or injection operation of the medicine, mixed liquid or mixed chemical liquid by the syringe 70. Here, the flow path 73a is a liquid flow path that allows the internal space of the drug container 50 and the mixed liquid container 60 and the internal space S2 of the syringe 70 to communicate with each other, and the flow path 73b is the flow path 73b. This is a flow passage for air that allows communication between the internal space of the container 60 and the external space. Further, the flow path 73b is provided with a hydrophobic filter, and therefore, the liquid in the medicine container 50 and the mixed liquid container 60 does not leak from here. According to this configuration, even if the amount of liquid in the drug container 50 and the mixed liquid container 60 is increased or decreased via the flow path 73a, the change in the internal pressure of the drug container 50 and the mixed container 60 is suppressed by the action of the flow path 73b. Therefore, the suction or injection operation by the syringe 70 becomes easy.

<7-16>
The main body of the mixing device and the mixed liquid container holding part may be connected by a flexible tube, and the internal space of the mixed liquid container 60 and the closed spaces S1 to S31 may be communicated with each other through this tube. Specifically, for example, a main body part that defines the closed spaces S1 to S31 and a mixed liquid container holding part 440 that can hold the mixed liquid container 60 are arranged near both ends of the tube 80 as shown in FIG. Embodiments are possible. According to such a configuration, during the mixing operation, the user can freely move the mixing apparatus with the mixed solution container 60 placed on a table or the like, and the weight of the mixed solution container 60 hinders the mixing operation. Can be prevented. That is, in the mixing device in which the drug container 50, the mixed solution container 60, and the syringe 70 are attached, the weight of the mixed solution container 60 is expected to be large, but the mixed solution container 60 is removed via the tube 80. By physically moving away from the main body of the mixing device, the user need not support the weight of the mixed liquid container 60 during the mixing operation.

  The details of the example of FIG. 22 will be described. On the main body portion side, a connection portion 450 that forms a communication port between the closed spaces S1, S11, S21, and S31 and the tube 80 is provided. Is provided with a connecting portion 441 that forms a communication port between the needle 442 pierced by the bottle stopper 62 of the mixed liquid container 60 and the tube 80. During the mixing operation, the user pierces the needle 442 near the center of the bottle stopper 62 of the mixed liquid container 60 and causes the internal space of the mixed liquid container 60 and the closed spaces S1 to S31 to communicate with each other through the tube 80. At this time, if the bottle stopper 62 is sandwiched between the clips 460 and the like, the danger that the internal space of the mixed liquid container 60 is exposed to the external space due to the puncture of the needle 442 can be more reliably eliminated. Thereafter, the medicine is extracted from the medicine container 50 into the syringe 70 in the closed spaces S1 to S31, and the needle 73 of the syringe 70 is aligned with the connection portion 450. In this state, when a drug is injected into the tube 80 from the syringe 70 via the connection portion 450, the drug is injected into the mixed solution container 60 through the tube 80, and a mixed drug solution is generated.

  The needle 442 is a needle with a soft sheath 443 similar to the soft sheath 74 of FIG. Therefore, when the mixed chemical solution is generated and the mixed solution container 60 is removed from the mixed solution container holding portion 440, the state returns to the same state as shown in FIG. 22A before the needle 442 is pierced through the bottle stopper 62. Therefore, the needle 442 exposed to the medicine is automatically stored in the soft sheath 443 as the needle 442 is pulled out from the bottle stopper 62, and the medicine diffuses from the needle 442 after the mixing operation. Can be prevented.

<7-17>
Considering the workability of the mixing work by the user, the mixing device that can be placed on a table or the like has a structure that is difficult to roll in a state where all or part of the medicine container 50, the mixed liquid container 60, and the syringe 70 are attached. It is preferable to do this.
For example, in the mixing apparatus 101 according to the second embodiment, the main body 110 has a columnar shape, and the side surface of the main body 110 is attached to any combination of the drug container 50, the mixed liquid container 60, and the syringe 70. As a rolling surface, it can easily roll on a table or the like under a slight external force. Therefore, for example, as shown in FIG. 23A, by attaching a polygonal (rectangular in the drawing) plate 115 to the bottom surface portion 111a of the main body 110 (however, at the mounting position of the mixed liquid container 60, An opening is formed in the plate 115), and the mixing device 101 can be made difficult to roll. Or as shown in FIG.23 (b), the protrusion or rib 116 which protrudes outside may be provided in the side part 111b and the side part 112b of the main-body part 110, and you may make the mixing apparatus 101 difficult to roll.

As another example, the mixing apparatus 1 according to the first embodiment also has a main body 10 having a substantially truncated cone shape, so that the inclined surface (conical surface portion 10b) serves as a rolling surface and receives a slight external force so that the top of the table or the like. Can be said to be easy to roll. Therefore, in the mixing device 1 as well, the mixing device 1 is rolled by attaching a polygonal plate to the bottom surface of the main body 10 or providing a rib or protrusion protruding outward on the conical surface portion 10b of the main body 10. It may be difficult.
Further, as a method of making the mixing device difficult to roll, a method of biasing the center of gravity to a specific location of the mixing device can be considered.

<7-18>
In 5th Embodiment, you may automate a part or all of the operation | movement which concerns on the mixing operation | work of the chemical | medical agent and liquid mixture by the mixing assistance apparatus 2 and the mixing apparatus 101. FIG. For example, as a method for automating the operations of the mixing support apparatus 2 and the mixing apparatus 101, it is conceivable to change the mixing support apparatus 2 to the mixing support apparatus 102 shown in FIG. The main differences between the mixing support device 2 and the mixing support device 102 are ascending / descending by the elevating mechanism 513, rotation around the slider 513b of the shaft 512, rotation around the knob portion 112c of the lid portion 112 of the mixing device 101, and syringe holding. The mixing support device 102 additionally includes a microcomputer 90 that controls the deformation of the portion 120 and the reciprocating motion of the piston 72 with respect to the cylinder 71 and various mechanisms 91 to 95 that are required for automating these operations. .

  Specifically, a stepping motor 91 fixed to another shaft that is embedded in the shaft 512 without play is provided in the slider 513b. When the rotation amount is controlled by the microcomputer 90 and the stepping motor 91 rotates, the shaft 512 rotates around the slider 513b. In the bearing 514, a grip 92 for gripping the knob portion 112c from above and a stepping motor 93 for rotating the grip 92 are provided. When the microcomputer 90 controls the amount of rotation and the stepping motor 93 rotates, the lid 112 rotates around the knob 112c. Further, a gripping mechanism 94 that grips the cylinder 71 and tilts left and right while moving up and down, and an insertion / removal mechanism 95 that inserts and removes the piston 72 with respect to the cylinder 71 are provided. 90. Note that the microcomputer 90 can automatically cause the mixing support apparatus 2 to execute a mixing operation in response to a user instruction by executing a control program stored in advance.

<7-19>
The mixing apparatus that can support the mixing work by the mixing support apparatus 2 is not limited to the mixing apparatus 101, and for example, it is possible to support the mixing work by the mixing apparatus 201 according to the third embodiment. However, in this case, it is necessary to change the mixing support apparatus 2 as appropriate. In the example of the mixing apparatus 201, a mechanism or the like that slides the syringe holding portion 220 relative to the bearing 514 may be prepared instead of the mechanism that rotates the knob portion 112c relative to the bearing 514.

<7-20>
The number of syringes 70 that can be simultaneously held by the syringe holding unit in a state where the needle 73 and the closed space can communicate with each other may not be one, but may be plural. Such a modification can be realized, for example, by providing a plurality of the above-described syringe holding portions 20, 120, 220, and 320 in parallel at appropriate positions of the main body portions 10, 110, 210, and 313 as syringe holding portions. it can. Moreover, you may make it hold | maintain in the aspect from which the some syringe 70 branches from the specific site | part of a syringe holding part.

1, 101, 201, 301 Mixing device 2,102 Mixing support device S1, S11, S21, S31 Closed space 10, 110, 210, 313 Main body portion 20, 120, 220, 320 Syringe holding portion 30, 130, 230, 330 Drug container holding unit 40, 140, 240, 340 Mixed solution container holding unit 50 Drug container 60 Mixed solution container 70 Syringe 73 Needle 510 Direction changing mechanism 514 Bearing 515 Support member 90 Control unit

Claims (18)

A mixing device that mixes a medicine contained in one or more medicine containers and a mixed liquid contained in one or more liquid mixture containers using a syringe having a flow part for sucking and discharging liquid,
A main body having a closed space;
A syringe holding part capable of holding the syringe in a state where the circulation part and the closed space can communicate with each other;
A drug container holding part capable of holding the one or more drug containers in a state where the inside of the drug container and the closed space can communicate with each other;
A liquid mixture container holding part capable of detachably holding the one or more liquid mixture containers outside the closed space in a state in which the inside of the liquid mixture container and the closed space can communicate with each other;
The syringe holding part is configured so that the flow part communicates with the inside of the closed space so that the flow part communicates with the inside of the drug container and the liquid mixture container after the flow part communicates with the closed space. And the syringe can be held in a movable state relative to the inside of the liquid mixture container.
Mixing device. The syringe holding part can be flexibly deformed to move the flow part relative to the inside of the drug container and the mixed liquid container in the closed space.
The mixing device according to claim 1. The syringe holding part has a bellows structure,
The mixing apparatus according to claim 2. The drug container holding part is capable of holding the at least one drug container in a state where the at least one drug container is inclined with respect to a direction in which the flow part accesses the inside of the mixed liquid container.
The mixing device according to any one of claims 1 to 3. The drug container holding portion is accommodated in the closed space and can hold the drug container so that the drug container is accommodated in the closed space.
The mixing apparatus according to any one of claims 1 to 4. The syringe holding part is capable of relatively rotating and moving between at least two of the one or more drug containers and the one or more mixed liquid containers in the closed space. Can hold the syringe,
The mixing apparatus according to any one of claims 1 to 5. The syringe holding part is capable of relatively linearly moving between at least two of the one or more drug containers and the one or more mixed liquid containers in the closed space. Can hold the syringe,
The mixing apparatus according to any one of claims 1 to 6. The drug container holding unit can hold the plurality of drug containers so that the inside of the plurality of drug containers can be communicated with the closed space simultaneously or continuously.
The mixing apparatus according to any one of claims 1 to 7. At least a part of the main body part, the syringe holding part, the drug container holding part, and the mixed liquid container holding part are transparent so that the closed space can be visually recognized from the outside.
The mixing apparatus according to claim 1. The syringe circulation part has a needle,
The lids of the drug container and the liquid mixture container are pierced by the needle of the flow part, whereby the inside of each container communicates with the internal space of the syringe.
The mixing device according to any one of claims 1 to 9. The syringe holding part has a needle in the closed space that is connected to the flow part while holding the syringe.
The mixing device according to any one of claims 1 to 9. A mixing support device for supporting mixing of the medicine and the mixed solution using the mixing device according to any one of claims 1 to 11,
By changing the direction of the mixing device in a state where the syringe and at least one of the one or more drug containers and the one or more mixed liquid containers are held, the direction of the syringe and the at least An orientation changing mechanism for changing the orientation of one container;
Mixing support device. The circulation part of the syringe held in the syringe holding part is relatively disposed between at least two of the one or more drug containers and the one or more mixed liquid containers in the closed space. Further comprising a moving mechanism for moving,
The mixing support apparatus according to claim 12. A control unit for controlling the operation of at least one of the orientation changing mechanism and the moving mechanism;
The mixing support apparatus according to claim 12 or 13. The syringe holding part is capable of holding a plurality of the syringes in a state where the circulation part and the closed space can communicate with each other.
The mixing support apparatus according to claim 1. Preparing a syringe having a flow part for sucking and discharging liquid; and
Providing a mixing device having a closed space;
Holding the one or more drug containers with respect to the mixing device in a state where the inside of the one or more drug containers containing the drug and the closed space can communicate with each other;
Holding the syringe with respect to the mixing device in a state in which the circulation part and the closed space can communicate with each other;
Holding the one or more mixed solution containers detachably from the mixing device outside the closed space in a state where the inside of the mixed solution container containing the mixed solution and the closed space can communicate with each other;
After the flow part is communicated with the closed space, the flow part is communicated with the drug container and the liquid mixture container in the closed space so that the flow part communicates with the inside of the drug container and the liquid mixture container. Generating a mixed drug solution in which the drug and the mixed solution are mixed inside at least one of the syringe, the drug container, and the mixed solution container, while being moved relative to the inside of
Comprising
Mixing method. The step of generating the mixed chemical liquid includes
Moving the flow part relative to the inside of the drug container in the closed space so that the flow part communicates with the drug container;
Sucking the drug into the syringe after communicating the flow part with the inside of the drug container;
Moving the flow part relative to the inside of the liquid mixture container in the closed space so that the flow part communicates with the liquid mixture container after the drug is sucked into the syringe;
Injecting the drug in the syringe into the mixed solution container after communicating the flow part with the mixed solution container;
The mixing method according to claim 16. Removing the mixed solution container from the mixing device;
A step of discarding the mixing device, the drug container and the syringe while holding the drug container and the syringe with respect to the mixing device;
The mixing method according to claim 17.