JP2013181011A - Liquid composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a liquid composition for an oral cavity in which flavor standing of perfume origin and refrigerant are sufficiently provided though a large quantity of water is contained, and that exerts excellent storage stability.SOLUTION: A liquid composition for an oral cavity includes the following ingredient (A), (B), (C), and (D): (A) 0.01-0.5% by mass of myristoyl glutamate; (B) one or two or more nonionic surfactants chosen from a polyoxyethylene hardened castor oil, a glycerine fatty acid ester, and a sugar fatty acid ester; (C) an oil soluble perfume; and (D) 90% by mass of water, wherein a mass ratio (B)/(A) of the ingredient (B) to the ingredient (A) is 5-50.

Description

  The present invention relates to a liquid oral composition.

  Liquid oral compositions often contain oil-soluble ingredients such as oil-soluble fragrances and oil-soluble medicinal ingredients in a large amount of water, and these ingredients provide a desired effect. Since these liquid oral compositions are also required to have high transparency from the viewpoint of commercial value, various surfactants are usually used to improve the transparency by solubilizing these oil-soluble components in water. Is used.

  For example, Patent Document 1 contains cetylpyridinium chloride as a cationic fungicide, myristoyl glutamate as an anionic surfactant, polyoxyethylene hydrogenated castor oil as a nonionic surfactant, and tripolyphosphate. A liquid oral composition has been disclosed, and it is described that such a composition provides a bactericidal effect on airborne bacteria and biofilms and increases the smoothness of teeth. Patent Document 2 discloses that isopropyl methylphenol, sodium myristoyl glutamate, and polyoxyethylene hydrogenated castor oil are used in combination to increase the smoothness of teeth while enhancing the biofilm bactericidal power, and have good low-temperature storage stability. A liquid oral composition is disclosed. In addition, these documents also describe that a wide variety of fragrances can be blended.

  On the other hand, Patent Document 3 discloses a liquid oral composition containing a calcium ion supply compound, an anionic surfactant and a nonionic surfactant, and allows calcium ions to stably coexist with such a composition. It is described that it can exert a caries preventive effect. Furthermore, it is described that a fragrance can be blended in reducing the bitter taste of the nonionic surfactant.

JP 2010-143843 A JP 2009-143843 A JP 2005-187437 A

  However, as a result of investigation by the present inventor, as the amount of water in the composition increases, it is increasingly difficult to achieve both the stability of the components and the effect of the fragrance, In any of these documents, no attention is paid to the amount of water, and no detailed examination is made.

  Accordingly, an object of the present invention is to provide a liquid oral composition that sufficiently brings out a flavor and a refreshing feeling derived from a fragrance and also exhibits excellent storage stability while containing a large amount of water. .

  Therefore, as a result of intensive studies, the present inventor, after containing a large amount of water, combined use of a specific nonionic surfactant and an oil-soluble fragrance at a specific quantitative ratio, The present inventors have found that a liquid oral composition capable of exhibiting good storage stability while improving the refreshing feeling is obtained, and the present invention has been completed.

That is, the present invention includes the following components (A), (B), (C) and (D):
(A) Myristoyl glutamate 0.01-0.5% by mass
(B) Polyoxyethylene hydrogenated castor oil, glycerin fatty acid ester and sugar fatty acid ester at least one or two or more nonionic surfactants (C) oil-soluble perfume (D) water contains 90% by mass or more The liquid oral composition whose mass ratio ((B) / (A)) of a component (B) and a component (A) is 5-50 is provided.

  According to the liquid oral cavity composition of the present invention, while containing a large amount of water, it has excellent flavor standing immediately after use and can also provide a good refreshing feeling, and these effects can be maintained for a long time. Therefore, it is possible to obtain a good feeling of use and excellent storage stability. Therefore, it is possible to sufficiently exhibit the original flavoring of the fragrance while effectively reducing off-flavors such as bitterness.

Hereinafter, the present invention will be described in detail.
The liquid oral cavity composition of the present invention contains 0.01 to 0.5% by mass of myristoyl glutamate (A). Such component (A) can enhance the smoothness of the teeth, and in combination with the nonionic surfactant of component (B) described later, the mass ratio of component (B) to component (A) ((B) / When (A)) is from 5 to 50, it is possible to achieve solubilization of the oil-soluble fragrance of component (C) while increasing the water content. While providing a sufficient feeling, it can also exhibit excellent storage stability.

  Examples of such myristoyl glutamate (A) include alkali metal salts such as sodium salt and potassium salt of myristoyl glutamic acid. Of these, sodium salts are preferred from the viewpoints of solubility in water and availability. Specifically, as the component (A), for example, commercially available products such as Amisurfact (registered trademark) manufactured by Asahi Kasei Chemicals Corporation and Amisoft (registered trademark) MS-11 manufactured by Ajinomoto Co., Inc. should be used. Can do.

  The content of myristoyl glutamate (A) is 0.01 to 0.5% by mass in the composition for liquid oral cavity of the present invention from the viewpoint of storage stability and taste, and preferably 0.015 to It is 0.1 mass%, More preferably, it is 0.018-0.03 mass%.

  The composition for liquid oral cavity of the present invention contains at least one or two or more nonionic surfactants (B) selected from polyoxyethylene hydrogenated castor oil, polyglycerin fatty acid ester and sugar fatty acid ester. Such a nonionic surfactant of component (B) has the effect of improving the storage stability of the composition while solubilizing the oil-soluble fragrance of component (C).

  Examples of the component (B) polyoxyethylene hydrogenated castor oil include those having a polyoxyethylene polymerization degree of preferably 5 to 120, more preferably 10 to 100, and still more preferably 15 to 50 are listed.

  Examples of the polyglycerol fatty acid ester of the component (B) include those having a glycerin condensation degree of preferably 2 to 20, more preferably 5 to 12. Moreover, as a fatty-acid part of polyglyceryl fatty acid ester, a C6-C24 saturated or unsaturated fatty acid is mentioned, for example, From a stability viewpoint, a C12-C18 saturated or unsaturated fatty acid, for example, laurin Acid, myristic acid, palmitic acid and stearic acid are preferred.

  As the sugar fatty acid ester of component (B), for example, the number of carbon atoms in the sugar is preferably 6-18, more preferably 10-14, and still more preferably 12. Specific examples include sucrose fatty acid esters, maltose fatty acid esters, and lactose fatty acid esters. Of these, sucrose fatty acid esters are preferred from the viewpoints of taste and stability. Examples of the fatty acid portion of the sugar fatty acid ester include saturated or unsaturated fatty acids having 6 to 24 carbon atoms. From the viewpoint of stability, saturated or unsaturated fatty acids having 12 to 18 carbon atoms, such as lauric acid and myristin. Acid, palmitic acid and stearic acid are preferred.

  Among these nonionic surfactants, from the viewpoint of solubilizing the oil-soluble fragrance of component (C), and from the viewpoints of flavor standing, persistence of refreshment, persistence of irritation, and improvement of storage stability, polyoxyethylene-cured castor Oil is preferred. The content of the nonionic surfactant of the component (B) is preferably 0.01 to 2% by mass, more preferably in the liquid oral composition of the present invention, from the viewpoint of stability and taste. It is 0.05-1 mass%, More preferably, it is 0.1-0.3 mass%.

  In the composition for liquid oral cavity of the present invention, the mass ratio ((B) / (A)) of the component (B) and the component (A) is used while reducing the bitterness and the like derived from the component (B). Immediately after that, it is 5 to 50, preferably 7 to 12 from the viewpoint of effectively enhancing the flavor standing derived from the component (C) and maintaining these effects to provide a good feeling of use.

  The liquid composition for oral cavity of the present invention contains an oil-soluble fragrance (C). Such component (C) masks off-flavors such as bitterness, emits a good scent, and can also bring a refreshing feeling. Examples of the fragrance containing the component (C) include synthetic fragrances such as menthol, carvone, camphor, anethole, eugenol, cineol, thymol, methyl salicylate, pregon, menthone, pinene, limonene, menthyl acetate, etc .; peppermint oil, spearmint Oil, mint oil such as peppermint oil, citrus oil such as lemon, orange, grapefruit, lime, herbal oil such as eucalyptus, sage, rosemary, thyme, laurel, basil, perilla, bay, estragon, parsley, celery, coriander, Natural essential oils such as cinnamon, pepper, nutmeg, mace, clove, ginger, cardamom, anise and other spice oils; apple, banana, melon, grape, peach, strawberry, blueberry, raspberry, blackcurrant, lychee Star fruit, passion fruit, plum, pineapple, include fruit flavors such as Muscat. These oil-soluble fragrances (C) may be used singly or in combination of two or more.

  Among these, menthol, carvone, camphor, menthone, methyl salicylate, cineol, limonene, and pinene are preferable, and at least menthol is more preferable from the viewpoint of imparting a refreshing feeling and refreshingness to the oral cavity.

  When the oil-soluble fragrance | flavor of a component (C) contains menthol, content of menthol in a component (C) becomes like this. Preferably it is 10 mass% or more, More preferably, it is 25-70 mass%. The liquid oral composition of the present invention has a relatively low water solubility among oil-soluble fragrances, and even if the content is increased while using menthol, which is difficult to solubilize, the flavor A good refreshing feeling can be brought about without impairing the standing, and performance derived from menthol can be sufficiently imparted.

  In the composition for liquid oral cavity of the present invention, the mass ratio ((C) / (A)) of the component (C) and the component (A) is sufficient to achieve solubilization of the component (C) and the component (C ) From the viewpoint of sufficiently exhibiting the performance derived from, it is preferably 1 to 20, more preferably 2 to 10, and further preferably 3 to 8.

  The liquid composition for oral cavity of the present invention contains 90% by mass or more of water (D). In this way, it is possible to sufficiently increase the water content and bring about a refreshing feeling of use without a sense of incongruity, and to sufficiently maintain the effect without inhibiting the flavoring derived from the fragrance. it can.

  The water content of the component (D) is 90% by mass or more from the viewpoint of sufficiently solubilizing the content components while sufficiently increasing the water content, and from the viewpoint of sufficiently exerting the performance derived from the fragrance. , Preferably it is 90-99 mass%, More preferably, it is 92-97 mass%, More preferably, it is 93-96 mass%.

  In the composition for liquid oral cavity of the present invention, the mass ratio ((D) / (A)) of the component (D) and the component (A) is sufficient to achieve the solubilization of the component (A) and the component (A). ) From the viewpoint of sufficiently exhibiting the performance derived from, it is 2000-15000, more preferably 2500-10000, and still more preferably 3000-9000.

Moreover, the composition for liquid oral cavity of this invention may contain anionic surfactants other than a component (A).
Examples of the anionic surfactant other than the component (A) include alkyl sulfate salts such as sodium lauryl sulfate and sodium myristyl sulfate; N-acyl amino acid salts other than myristoyl glutamate such as sodium lauroyl sarcosine; sodium lauroyl methyl taurate and the like. Acyl taurine salts; fatty acid ester sulfonates such as coconut oil fatty acid ethyl ester sulfonate sodium salt and the like. The content of the anionic surfactant other than these components (A) is preferably 0.5% by mass or less in the liquid oral composition of the present invention from the viewpoint of irritation and taste, and more preferably 0.8%. It is 1 mass% or less, More preferably, it is 0.01 mass% or less, More preferably, it is 0.001 mass% or less, or it is preferable not to contain.

  Furthermore, the composition for liquid oral cavity of the present invention is a component other than the above components, for example, a component (for example, component (C) within a range that does not impair both excellent storage stability and imparting flavor and imparting a refreshing feeling due to component (C). Non-ionic surfactants other than B); sugar alcohols such as xylitol and sorbitol; polyhydric alcohols such as propylene glycol, glycerin and polyethylene glycol, as well as medicinal agents, buffers, binders, sweeteners, solvents, etc. can do. The content of the nonionic surfactant other than the component (B) is preferably 0.5% by mass or less, more preferably 0.1% by mass or less, in the liquid oral composition of the present invention. More preferably, it is 0.01 mass% or less, More preferably, it is 0.001 mass% or less, or it is preferable not to contain. The content of the polyhydric alcohol is preferably 0.01 to 5.5% by mass, more preferably 0.1 to 5% by mass, and further preferably 0 in the liquid oral composition of the present invention. .5 to 4.5% by mass. The content of the sugar alcohol is preferably 0.01 to 3% by mass, more preferably 0.1 to 2% by mass, and still more preferably 0.5 to 3% by mass in the liquid oral composition of the present invention. 1.5% by mass.

  The composition for liquid oral cavity of the present invention is a highly transparent aqueous liquid containing a large amount of water, and can be applied to liquid toothpaste, water toothpaste, mouthwash, mouth spray, mouthwash and the like. Especially, it is preferable to apply to a liquid dentifrice or a mouthwash from a viewpoint which can fully exhibit the effect of this invention.

  Hereinafter, the present invention will be specifically described based on examples. In addition, unless otherwise indicated in a table | surface, content of each component shows the mass%.

[Examples 1-6, Comparative Examples 1-6]
Each component described in Table 1 was mixed to prepare a mouthwash. About the obtained mouthwash, the flavor test and the stability test were done according to the method shown below, and each evaluation was performed. The results are shown in Table 1.

<Flavor test>
A special panel was used to evaluate the flavor standing. Mouthed with 10 mL of mouthwash for 20 seconds, the flavor remaining in the mouth when exhaled (immediately after use), and the refreshing and irritating sensation in the oral cavity after 10 minutes of use Continuation) was evaluated in five stages according to the following criteria, and the average value of three professional panelists was calculated and evaluated according to the following criteria.

(1) Standing flavor (immediately after use)
<Evaluation criteria>
5 points: good flavor standing 4 points: slightly good flavor standing 3 points: Neither can be said 2 points: slightly bad flavor standing 1 point: poor flavor standing <Criteria>
◎: 3.5 points or more ○: 3 points or more and less than 3.5 points △: 2.5 points or more and less than 3 points ×: Less than 2.5 points

(2) Persistence of coolness (after 10 minutes)
<Evaluation criteria>
5 points: There is a refreshing feeling 4 points: There is a little refreshing feeling 3 points: It can be said neither 2 points: There is not much refreshing feeling 1 point: There is no refreshing feeling
◎: 3.5 points or more ○: 3 points or more and less than 3.5 points △: 2.5 points or more and less than 3 points ×: Less than 2.5 points

(3) Persistence of irritation (after 10 minutes)
<Evaluation criteria>
5 points: Stimulated 4 points: Slightly stimulated 3 points: Neither can be said 2 points: Not much stimulated 1 point: No stimulus <Criteria>
◎: 3.5 points or more ○: 3 points or more and less than 3.5 points △: 2.5 points or more and less than 3 points ×: Less than 2.5 points

<Stability test>
The prepared composition was put into a transparent PET container and stored at 5 ° C. for 1 week, and the storage stability was evaluated according to the criteria shown below.
<Criteria>
◎: Transparent ○: Slightly transparent △: Precipitation occurred, but it became transparent when returned to room temperature ×: Precipitation occurred and clouded

  From the results shown in Table 1, Examples 1 to 6 are superior to Comparative Examples 1 to 6 in terms of flavor standing in the mouth immediately after use, and are also excellent in the refreshing feeling and irritation in the oral cavity after aging. It can be seen that the storage stability is high. On the other hand, in addition to Comparative Example 1 using N-lauroyl-L-glutamate sodium instead of Component (A) and Comparative Example 2 using N-lauroyl sarcosinate-sodium, Comparative Example 3 containing no component (A) In -4, the flavor immediately after use, the refreshing feeling after 10 minutes and the persistence of irritation cannot be obtained, and the mass ratio of component (B) to component (A) ((B) / (A)) is in the above range. Outer Comparative Example 5 was poor in storage stability.

Claims (6)

The following components (A), (B), (C) and (D):
(A) Myristoyl glutamate 0.01-0.5% by mass
(B) Polyoxyethylene hydrogenated castor oil, glycerin fatty acid ester and sugar fatty acid ester at least one or two or more nonionic surfactants (C) oil-soluble perfume (D) water contains 90% by mass or more The liquid oral cavity composition whose mass ratio ((B) / (A)) of a component (B) and a component (A) is 5-50.   The liquid oral composition of Claim 1 in which a component (C) contains at least 1 sort (s) or 2 or more types chosen from menthol, peppermint oil, spearmint oil, eucalyptus oil, and rosemary oil.   The composition for liquid oral cavity according to claim 1 or 2, wherein the component (C) contains at least menthol.   The liquid oral composition according to claim 2 or 3, wherein the content of menthol in the component (C) is 10% by mass or more.   The liquid oral composition according to any one of claims 1 to 4, wherein the mass ratio ((D) / (A)) of the component (D) to the component (A) is 2300 to 15000.   The liquid oral composition according to any one of claims 1 to 5, wherein the mass ratio of the component (C) to the component (A) ((C) / (A)) is 1 to 20.