JP2013147442A5 - - Google Patents
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- JP2013147442A5 JP2013147442A5 JP2012007796A JP2012007796A JP2013147442A5 JP 2013147442 A5 JP2013147442 A5 JP 2013147442A5 JP 2012007796 A JP2012007796 A JP 2012007796A JP 2012007796 A JP2012007796 A JP 2012007796A JP 2013147442 A5 JP2013147442 A5 JP 2013147442A5
- Authority
- JP
- Japan
- Prior art keywords
- surface tension
- ester oil
- fatty acid
- less
- acid ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000010696 ester oil Substances 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 229940073144 Glycyrrhetinic acid Drugs 0.000 description 1
- MPDGHEJMBKOTSU-YKLVYJNSSA-N Glycyrrhetinic acid Natural products C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 1
- 210000003491 Skin Anatomy 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- WNIFXKPDILJURQ-JKPOUOEOSA-N octadecyl (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@](C(=O)OCCCCCCCCCCCCCCCCCC)(C)C[C@H]5C4=CC(=O)[C@@H]3[C@]21C WNIFXKPDILJURQ-JKPOUOEOSA-N 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 230000037335 skin penetration Effects 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
Description
本発明の皮膚浸透促進剤は、少なくとも１種の分岐構造を有する脂肪酸エステル油からなり、温度２０℃における表面張力が２９．５ｍＮ／ｍ以下であることを特徴とする。好ましくは表面張力が２８．５ｍＮ／ｍ以下であり、より好ましくは２８ｍＮ／ｍ以下である。表面張力が低いほど、前記エステル油が皮膚表面に伸び広がり易くなり、それに伴いグリチルレチン酸ステアリルの皮膚浸透性もより促進される。効果の観点で、表面張力の下限値については特に制限はないが、一般的には、脂肪酸エステル油の表面張力の下限値は２３ｍＮ／ｍ程度になる。さらに表面張力が低いことで知られているハイドロフルオロカーボン類では１２〜１８ｍＮ／ｍ、ジメチルポリシロキサン類では２０〜２１ｍＮ／ｍであるがこれらはグリチルレチン酸ステアリルの溶解度がほとんどなく、本願の脂肪酸エステル油とは異なる。
なお、本明細書では、表面張力とは、ペンダント・ドロップ法により測定される表面張力の値をいうものとする。
The skin penetration enhancer of the present invention comprises a fatty acid ester oil having at least one branched structure, and has a surface tension of 29.5 mN / m or less at a temperature of 20 ° C. The surface tension is preferably 28.5 mN / m or less, more preferably 28 mN / m or less. The lower the surface tension, the more easily the ester oil spreads on the skin surface, and accordingly, the skin permeability of stearyl glycyrrhetinate is further promoted. From the viewpoint of the effect, the lower limit value of the surface tension is not particularly limited, but generally the lower limit value of the surface tension of the fatty acid ester oil is about 23 mN / m. Moreover 12 to 18 m N / m in hydrofluorocarbons surface tension are known in the low that almost no solubility of glycyrrhetinic acid stearyl these are is 20-21 m N / m at dimethylpolysiloxanes, herein This is different from the fatty acid ester oil.
In this specification, the surface tension refers to the value of the surface tension measured by the pendant drop method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012007796A JP2013147442A (en) | 2012-01-18 | 2012-01-18 | Skin permeation promoter for stearyl glycyrrhetinate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012007796A JP2013147442A (en) | 2012-01-18 | 2012-01-18 | Skin permeation promoter for stearyl glycyrrhetinate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013147442A JP2013147442A (en) | 2013-08-01 |
| JP2013147442A5 true JP2013147442A5 (en) | 2015-02-26 |
Family
ID=49045322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012007796A Pending JP2013147442A (en) | 2012-01-18 | 2012-01-18 | Skin permeation promoter for stearyl glycyrrhetinate |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2013147442A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6348253B2 (en) * | 2012-01-27 | 2018-06-27 | 株式会社コーセー | Emulsion composition containing stearyl glycyrrhetinate |
| JP2015134736A (en) * | 2014-01-17 | 2015-07-27 | ニベア花王株式会社 | Pore penetration enhancer, antimicrobial composition, deodorizing composition, and antiperspirant and deodorizing composition of glycyrrhetic acid |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2732223B1 (en) * | 1995-03-30 | 1997-06-13 | Sanofi Sa | PHARMACEUTICAL COMPOSITION FOR TRANSDERMAL ADMINISTRATION |
| JPH1077216A (en) * | 1996-09-04 | 1998-03-24 | Kanebo Ltd | Hair-restoring cosmetic material |
| JP3113844B2 (en) * | 1996-11-15 | 2000-12-04 | 花王株式会社 | Cosmetics |
| JPH10204001A (en) * | 1996-11-15 | 1998-08-04 | Kao Corp | Percutaneous absorption accelerator |
| JPH11222412A (en) * | 1997-12-01 | 1999-08-17 | Shiseido Co Ltd | Skin preparation for external use |
| JP2000136122A (en) * | 1998-10-28 | 2000-05-16 | Kose Corp | Skin lotion |
| JP2004210727A (en) * | 2002-12-28 | 2004-07-29 | Lion Corp | Oily gel composition and oily pharmaceutical preparation composition for external use |
| JP4589050B2 (en) * | 2003-12-22 | 2010-12-01 | 日本精化株式会社 | Diesters and oils, and cosmetics and skin external preparations |
| JP4707997B2 (en) * | 2004-07-30 | 2011-06-22 | 昭和電工株式会社 | L-ascorbic acid-2-phosphate magnesium sodium salt, process for producing the same, and cosmetics containing the salt |
| WO2009025239A1 (en) * | 2007-08-17 | 2009-02-26 | Eisai R & D Management Co., Ltd. | Novel preparation for external use |
| US8728503B2 (en) * | 2009-11-06 | 2014-05-20 | Kao Corporation | Emulsion cosmetic |
| CN101920017B (en) * | 2010-07-31 | 2012-01-04 | 大连理工大学 | Composite for promoting glycyrrhetinic acid to realize percutaneous permeation |
-
2012
- 2012-01-18 JP JP2012007796A patent/JP2013147442A/en active Pending
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