JP2013128705A - Medical image forming apparatus, medical image forming program, and medical image forming method - Google Patents
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Abstract
Description
本発明は、画像診断を支援する画像生成技術に関するものであり、特にＣＴ（Computed
Tomography）、ＭＲＩ（Magnetic Resonance Imaging）等の医用画像撮像装置により得られた３次元画像データに基づき、診断に好適な２次元可視画像を生成し得る医用画像生成装置、医用画像生成プログラムおよび医用画像生成方法に関する。
The present invention relates to an image generation technique that supports image diagnosis, and in particular, CT (Computed).
Tomography), MRI (Magnetic Resonance Imaging), etc. Medical image generation apparatus, medical image generation program, and medical image capable of generating a two-dimensional visible image suitable for diagnosis based on three-dimensional image data obtained by a medical image imaging apparatus It relates to a generation method.
従来、ＣＴやＭＲＩ等により取得された３次元画像データに基づいて２次元可視画像を生成する方法として、ＭＰＲ（multiplanar reconstruction）表示やＣＰＲ（curved
planar reconstruction）表示等の表示方法が知られている（非特許文献１の第３７９〜３８２頁参照）。ＭＰＲ表示は、特定の位置における断面像を再構成する方法であるため、ＭＰＲ表示を用いた場合には、複雑な走行をしている管腔状組織（例えば血管）を１つの断面上に全て収まるように表示させることが難しい。これに対してＣＰＲ表示は、３次元画像データを２次元平面上に投影することで２次元可視画像を生成するため、ＭＰＲ表示では困難とされる複雑な走行をする管腔状組織を、効果的に２次元可視画像として集約して表示できるという利点がある。
Conventionally, as a method for generating a two-dimensional visible image based on three-dimensional image data acquired by CT, MRI or the like, MPR (multiplanar reconstruction) display or CPR (curved)
A display method such as planar reconstruction is known (see pages 379 to 382 of Non-Patent Document 1). Since the MPR display is a method for reconstructing a cross-sectional image at a specific position, when the MPR display is used, all the luminal tissues (for example, blood vessels) that are traveling in a complicated manner on one cross-section. It is difficult to display to fit. In contrast, CPR display generates a two-dimensional visible image by projecting three-dimensional image data onto a two-dimensional plane. In particular, there is an advantage that the two-dimensional visible images can be collected and displayed.
ところで、例えば血管の２次元可視画像を得るときに、血管に造影剤を投与した上で撮像することで、血管の内外にコントラストを付けた３次元画像データを取得でき、その結果、血管の読影がしやすい２次元可視画像を得ることが可能になる。また、引用文献１には、２次元可視画像のコントラストを観察しやすいように調整する機能を備えたＸ線撮影装置が開示されている。 By the way, for example, when obtaining a two-dimensional visible image of a blood vessel, it is possible to acquire three-dimensional image data with contrast inside and outside of the blood vessel by imaging the blood vessel after administering a contrast medium. It is possible to obtain a two-dimensional visible image that is easy to be damaged. Also, cited document 1 discloses an X-ray imaging apparatus having a function of adjusting the contrast of a two-dimensional visible image so that it can be easily observed.
一般に血管は、起始部から末梢部に進むに従って次第に血管径が細くなるが、血管の中には、末梢部において毛細血管レベルに達するものもある。このような血管を撮像する場合、特に末梢部において単位体積中に含まれる血管以外の周辺組織の割合が高くなり（部分体積効果と称される）、造影剤の効果が低下しやすい。また、例えば正常状態と比較して血管径が拡大する病気を患っている生体の場合、正常状態よりも血圧や血流速度が低下するため、血管の末梢部にまで造影剤を到達させることが困難になることがある。 In general, blood vessels gradually become smaller in diameter as they progress from the origin to the peripheral part, but some blood vessels reach the capillary level in the peripheral part. When such a blood vessel is imaged, the ratio of peripheral tissues other than the blood vessel contained in the unit volume in the peripheral part increases (referred to as a partial volume effect), and the effect of the contrast agent tends to decrease. In addition, for example, in the case of a living body suffering from a disease in which the blood vessel diameter expands compared to the normal state, the blood pressure and blood flow velocity are lower than in the normal state, so the contrast agent can reach the peripheral part of the blood vessel. It can be difficult.
そこで、このような場合であっても、読影に適したコントラストの２次元可視画像が得られるように、２次元平面に対して垂直な方向に例えば血管の起始部に対応した抽出幅で血管を抽出し、抽出された血管の信号値を２次元平面に投影することが行われている。 Therefore, even in such a case, the blood vessel is extracted with an extraction width corresponding to, for example, the start portion of the blood vessel in a direction perpendicular to the two-dimensional plane so that a two-dimensional visible image having a contrast suitable for interpretation can be obtained. And extracting the extracted blood vessel signal value on a two-dimensional plane.
ところが、上記のように抽出幅を血管の起始部に対応させて設定すると、特に末梢部においては、血管の周囲に位置する周辺組織が血管と一緒に大きく抽出されて、その信号値が２次元平面に投影される場合があった。このように周辺組織の信号値が一緒に投影される場合の具体例について、図７を参照しながら以下に説明する。 However, when the extraction width is set so as to correspond to the start part of the blood vessel as described above, the peripheral tissue located around the blood vessel is largely extracted together with the blood vessel, particularly in the peripheral part, and the signal value is 2 In some cases, it was projected onto a dimensional plane. A specific example in which the signal values of the surrounding tissue are projected together will be described below with reference to FIG.
図７（ａ）は、抽出幅が狭いために血管５００の読影に適したコントラストが得られていない場合を示したものである。図７（ｂ）は、図７（ａ）の場合よりも広い抽出幅が設定された場合であり、図７（ａ）の場合と比較して血管５００の読影に適したコントラストが得られているものの、一方で、周辺組織５９９も一緒に抽出されて投影されている。図７（ｃ）は、図７（ｂ）の場合よりも広い抽出幅が設定された場合であり、図７（ｂ）の場合と同様に血管５００の読影に適したコントラストが得られているものの、一方で、抽出幅が拡大された分だけ周辺組織５９９も広範囲に亘って抽出されて投影されている。このように、血管５００の読影に適したコントラストの２次元可視画像を生成しようとすると、周辺組織５９９も一緒に抽出されて血管５００に重なるように２次元可視画像に表示されるので、血管５００の正確な２次元可視画像を生成することが難しいという課題があった。 FIG. 7A shows a case where a contrast suitable for interpretation of the blood vessel 500 is not obtained because the extraction width is narrow. FIG. 7B shows a case where an extraction width wider than that in the case of FIG. 7A is set, and a contrast suitable for interpretation of the blood vessel 500 is obtained as compared with the case of FIG. 7A. On the other hand, the surrounding tissue 599 is also extracted and projected together. FIG. 7C shows a case where a wider extraction width is set than in the case of FIG. 7B, and a contrast suitable for interpretation of the blood vessel 500 is obtained as in the case of FIG. 7B. However, on the other hand, the surrounding tissue 599 is also extracted and projected over a wide range as the extraction width is expanded. As described above, when an attempt is made to generate a two-dimensional visible image having a contrast suitable for interpretation of the blood vessel 500, the surrounding tissue 599 is also extracted together and displayed on the two-dimensional visible image so as to overlap the blood vessel 500. There is a problem that it is difficult to generate an accurate two-dimensional visible image.
本発明は上記のような課題に鑑みてなされたものであり、周辺組織の影響を排除することで、管腔状組織の正確な２次元可視画像を生成可能な医用画像生成装置、医用画像生成プログラムおよび医用画像生成方法を提供することを目的とする。 The present invention has been made in view of the above problems, and a medical image generation apparatus and a medical image generation capable of generating an accurate two-dimensional visible image of a tubular tissue by eliminating the influence of surrounding tissues. It is an object to provide a program and a medical image generation method.
上記目的を達成するため、本発明に係る医用画像生成装置、医用画像生成プログラムおよび医用画像生成方法は、以下のように構成されている。 In order to achieve the above object, a medical image generation apparatus, a medical image generation program, and a medical image generation method according to the present invention are configured as follows.
すなわち、本発明に係る医用画像生成装置は、
医用画像撮像装置により撮像して取得された３次元医用画像データから、管腔状組織の３次元医用画像データを所定の抽出幅で抽出し、抽出された該管腔状組織の３次元医用画像データを画像空間内の所定の平面上に投影して、該管腔状組織の２次元観察用画像を生成する医用画像生成装置であって、
投影方向における前記管腔状組織の３次元医用画像データの抽出幅を、該管腔状組織における芯線の所定位置からの該芯線に沿った距離に応じ変化させて設定する抽出幅設定手段を備えたことを特徴とする。
That is, the medical image generation apparatus according to the present invention is
3D medical image data of a tubular tissue is extracted with a predetermined extraction width from 3D medical image data acquired by imaging with a medical image imaging device, and the extracted 3D medical image of the tubular tissue is extracted. A medical image generation apparatus for projecting data onto a predetermined plane in an image space and generating a two-dimensional observation image of the tubular tissue,
Extraction width setting means is provided for setting the extraction width of the three-dimensional medical image data of the tubular tissue in the projection direction in accordance with the distance along the core line from a predetermined position of the core line in the tubular tissue. It is characterized by that.
この医用画像生成装置において、前記抽出幅設定手段は、前記抽出幅を、前記芯線における前記所定位置からの該芯線に沿った距離に応じて小さくなるように設定する構成であることが好ましい。 In this medical image generation apparatus, it is preferable that the extraction width setting unit is configured to set the extraction width so as to become smaller according to a distance along the core line from the predetermined position in the core line.
また、前記抽出幅設定手段は、前記抽出幅を、前記芯線における前記所定位置からの該芯線に沿った距離に反比例する値に設定するように構成されたことが好ましい。 Further, it is preferable that the extraction width setting means is configured to set the extraction width to a value that is inversely proportional to the distance along the core line from the predetermined position in the core line.
なお、前記抽出幅設定手段は、次式を満たすように前記抽出幅を設定するように構成されたことも好ましい。
ｆ（ｘ）＝ｅｘｐ（−（ａ×ｘ））
ここで、ｘは前記距離であって正の値、ａは係数、ｆ（ｘ）は該距離がｘの位置における前記投影方向の抽出幅である。
The extraction width setting means is preferably configured to set the extraction width so as to satisfy the following expression.
f (x) = exp (− (a × x))
Here, x is the distance and is a positive value, a is a coefficient, and f (x) is the extraction width in the projection direction at the position where the distance is x.
さらに、前記管腔状組織の３次元医用画像データを、StraightenedＣＰＲ法により前記所定の平面上に投影するように構成されており、前記StraightenedＣＰＲ法により、前記管腔状組織の信号値を前記投影方向に積算して前記所定の平面上に投影する、該投影方向における該管腔状組織の最大信号値を該所定の平面上に投影する、または該投影方向における該管腔状組織の最小信号値を該所定の平面上に投影するように構成されたことが好ましい。 Furthermore, the three-dimensional medical image data of the tubular tissue is configured to be projected onto the predetermined plane by the Straightened CPR method, and the signal value of the tubular tissue is converted to the projection direction by the Straightened CPR method. And projecting onto the predetermined plane, projecting the maximum signal value of the luminal tissue in the projection direction onto the predetermined plane, or minimum signal value of the luminal tissue in the projection direction Is preferably projected onto the predetermined plane.
本発明に係る医用画像生成プログラムは、
医用画像撮像装置により撮像して取得された３次元医用画像データから、管腔状組織の３次元医用画像データを所定の抽出幅で抽出し、抽出された該管腔状組織の３次元医用画像データを画像空間内の所定の平面上に投影して、該管腔状組織の２次元観察用画像を生成する処理をコンピュータにおいて実行せしめる医用画像生成プログラムであって、
投影方向における前記管腔状組織の３次元医用画像データの抽出幅を、該管腔状組織における芯線の所定位置からの該芯線に沿った距離に応じ変化させて設定する抽出幅設定ステップをコンピュータにおいて実行せしめることを特徴とする。
A medical image generation program according to the present invention includes:
3D medical image data of a tubular tissue is extracted with a predetermined extraction width from 3D medical image data acquired by imaging with a medical image imaging device, and the extracted 3D medical image of the tubular tissue is extracted. A medical image generation program for projecting data on a predetermined plane in an image space and causing a computer to execute a process of generating a two-dimensional observation image of the tubular tissue,
An extraction width setting step for setting the extraction width of the three-dimensional medical image data of the tubular tissue in the projection direction in accordance with the distance along the core line from a predetermined position of the core line in the tubular tissue. It is made to perform in.
本発明に係る医用画像生成方法は、
医用画像撮像装置により撮像して取得された３次元医用画像データから、管腔状組織の３次元医用画像データを所定の抽出幅で抽出し、抽出された該管腔状組織の３次元医用画像データを画像空間内の所定の平面上に投影して、該管腔状組織の２次元観察用画像を生成する医用画像生成方法であって、
投影方向における前記管腔状組織の３次元医用画像データの抽出幅を、該管腔状組織における芯線の所定位置からの該芯線に沿った距離に応じ変化させて設定する抽出幅設定処理を行うことを特徴とする。
A medical image generation method according to the present invention includes:
3D medical image data of a tubular tissue is extracted with a predetermined extraction width from 3D medical image data acquired by imaging with a medical image imaging device, and the extracted 3D medical image of the tubular tissue is extracted. A medical image generation method for projecting data onto a predetermined plane in an image space and generating a two-dimensional observation image of the tubular tissue,
An extraction width setting process is performed in which the extraction width of the three-dimensional medical image data of the tubular tissue in the projection direction is set in accordance with the distance along the core line from a predetermined position of the core line in the tubular tissue. It is characterized by that.
本発明に係る医用画像生成装置は、投影方向における３次元医用画像データの抽出幅を、芯線における所定位置からの距離に応じ変化させて設定する抽出幅設定手段を備えて構成される。このため、例えば管腔状組織の表面に沿うように抽出幅を設定した場合には、周辺組織に対応する信号値が管腔状組織に対応する信号値を一緒に抽出されることを防止でき、管腔状組織の正確な２次元可視画像を生成可能になる。 The medical image generation apparatus according to the present invention includes an extraction width setting unit that sets the extraction width of the three-dimensional medical image data in the projection direction in accordance with the distance from a predetermined position on the core line. For this reason, for example, when the extraction width is set along the surface of the tubular tissue, it is possible to prevent the signal value corresponding to the surrounding tissue from being extracted together with the signal value corresponding to the tubular tissue. This makes it possible to generate an accurate two-dimensional visible image of the tubular tissue.
この医用画像生成装置において、所定位置からの芯線に沿った距離に応じて小さくなるように抽出幅を設定する構成の場合には、管腔状組織における径の変化に対応させて、管腔状組織の表面に沿うように抽出幅を設定することが可能になる。 In this medical image generating apparatus, in the case of a configuration in which the extraction width is set so as to become smaller according to the distance along the core line from a predetermined position, a tubular shape is made corresponding to a change in the diameter of the tubular tissue. The extraction width can be set along the surface of the tissue.
また、抽出幅を、所定位置からの芯線に沿った距離に反比例する値に設定する構成の場合には、簡易に抽出幅を設定できる構成でありながら、管腔状組織の正確な２次元可視画像を生成できる。 In the case of a configuration in which the extraction width is set to a value that is inversely proportional to the distance along the core line from a predetermined position, the extraction width can be easily set, but accurate two-dimensional visibility of the tubular tissue is possible. An image can be generated.
なお、抽出幅設定手段が、上述の式を満たすように抽出幅を設定する構成の場合には、管腔状組織の径を反映させた抽出幅を設定できるので、管腔状組織の正確な２次元可視画像を生成可能になる。 In the case where the extraction width setting unit is configured to set the extraction width so as to satisfy the above formula, the extraction width reflecting the diameter of the luminal tissue can be set, so that the accurate luminal tissue can be accurately determined. A two-dimensional visible image can be generated.
さらに、StraightenedＣＰＲ法により信号値を積算して投影する、最大信号値を投影する、または最小信号値を投影するように構成される場合、例えば管腔状組織の特性等に基づいて信号値を積算して投影する、最大信号値を投影する、または最小値を投影することを決定することにより、管腔状組織の形状等を忠実に反映させた２次元可視画像を生成することが可能になる。 Further, when the signal value is integrated and projected by the Straightened CPR method, the maximum signal value is projected, or the minimum signal value is projected, the signal value is integrated based on, for example, the characteristics of the luminal tissue. It is possible to generate a two-dimensional visible image that faithfully reflects the shape or the like of the luminal tissue by determining whether to project, to project the maximum signal value, or to project the minimum value. .
本発明に係る医用画像生成プログラムは、投影方向における抽出幅を、所定位置からの芯線に沿った距離に応じ変化させて設定する抽出幅設定ステップをコンピュータにおいて実行せしめるように構成されているので、管腔状組織の正確な２次元可視画像を自動で生成できる。 The medical image generation program according to the present invention is configured to cause the computer to execute an extraction width setting step for setting the extraction width in the projection direction by changing the extraction width according to the distance along the core line from the predetermined position. An accurate two-dimensional visible image of the tubular tissue can be automatically generated.
本発明に係る医用画像生成方法は、投影方向における抽出幅を、所定位置からの芯線に沿った距離に応じ変化させて設定する抽出幅設定処理を行うように構成されているため、管腔状組織の正確な２次元可視画像を自動で生成可能である。 The medical image generation method according to the present invention is configured to perform an extraction width setting process in which the extraction width in the projection direction is set in accordance with the distance from the predetermined position along the core line. An accurate two-dimensional visible image of the tissue can be automatically generated.
以下、本発明の実施形態について、上述の図面を参照しつつ詳細に説明する。まず、図１を参照しながら、本発明の一実施形態に係る医用画像生成装置１の装置構成について説明する。 Hereinafter, embodiments of the present invention will be described in detail with reference to the above-mentioned drawings. First, an apparatus configuration of a medical image generation apparatus 1 according to an embodiment of the present invention will be described with reference to FIG.
図１に示す医用画像生成装置１は、ＣＴやＭＲＩ等の画像撮像装置４により得られた生体組織の３次元画像データに基づき、マウスやキーボード等からなる操作装置３によって選択された生体組織の２次元可視画像を生成し、この２次元可視画像を画像表示装置２に表示させるものである。この医用画像生成装置１は、特に管腔状組織の２次元可視画像を正確に生成できる点に特徴を有するものである。 A medical image generation apparatus 1 shown in FIG. 1 is based on three-dimensional image data of a biological tissue obtained by an image imaging apparatus 4 such as CT or MRI, and the biological tissue selected by the operation device 3 including a mouse and a keyboard. A two-dimensional visible image is generated, and this two-dimensional visible image is displayed on the image display device 2. This medical image generation apparatus 1 is particularly characterized in that it can accurately generate a two-dimensional visible image of a tubular tissue.
医用画像生成装置１は、コンピュータ等から構成されており、図１に示すように、制御部１１、画像データ記憶部１２、可視画像記憶部１３、可視画像出力インタフェース１４、操作入力インタフェース１５および画像データ入力インタフェース１６を備えて構成される。 The medical image generation apparatus 1 includes a computer or the like, and as shown in FIG. 1, a control unit 11, an image data storage unit 12, a visible image storage unit 13, a visible image output interface 14, an operation input interface 15, and an image. A data input interface 16 is provided.
制御部１１は、各種の演算処理を行うＣＰＵにより構成され、データ抽出手段２０、抽出幅設定手段２１および投影手段２２を有する（詳細は後述）。画像データ記憶部１２および可視画像記憶部１３は、ハードディスク、ＲＡＭまたはＲＯＭ等の記憶装置により構成され、制御部１１との間で各種データの送受信が可能に設けられている。画像データ記憶部１２は、画像撮像装置４により断層撮影して得られた生体組織の３次元画像データ（ＣＴ画像データまたはＭＲＩ画像データ）を記憶するものである。可視画像記憶部１３は、制御部１１で生成された２次元可視画像を記憶するものである。 The control unit 11 includes a CPU that performs various arithmetic processes, and includes a data extraction unit 20, an extraction width setting unit 21, and a projection unit 22 (details will be described later). The image data storage unit 12 and the visible image storage unit 13 are configured by a storage device such as a hard disk, a RAM, or a ROM, and are provided so that various data can be transmitted to and received from the control unit 11. The image data storage unit 12 stores three-dimensional image data (CT image data or MRI image data) of a living tissue obtained by tomography with the image pickup device 4. The visible image storage unit 13 stores the two-dimensional visible image generated by the control unit 11.
可視画像出力インタフェース１４は、制御部１１から出力された２次元可視画像（２次元可視画像データ）を画像表示装置２に伝達するインタフェースである。操作入力インタフェース１５は、操作装置３からの各種操作信号を制御部１１に伝達するインタフェースである。画像データ入力インタフェース１６は、画像撮像装置４から出力された３次元画像データを制御部１１に伝達するインタフェースである。 The visible image output interface 14 is an interface that transmits the two-dimensional visible image (two-dimensional visible image data) output from the control unit 11 to the image display device 2. The operation input interface 15 is an interface that transmits various operation signals from the operation device 3 to the control unit 11. The image data input interface 16 is an interface that transmits the three-dimensional image data output from the image capturing device 4 to the control unit 11.
次に、医用画像生成装置１による２次元可視画像の生成手順について、主に図２〜図６を参照しながら説明する。以下においては、被検体である生体を画像撮像装置４により断層撮影し、断層撮影して得られた複数の３次元画像データの信号値に基づいて、管腔状組織の一例としての血管５０（後述する周囲血管９８，９９と区別するため、以降の説明では注目血管５０と称する）の２次元可視画像を生成する場合を例に挙げて説明する。 Next, a procedure for generating a two-dimensional visible image by the medical image generating apparatus 1 will be described with reference mainly to FIGS. In the following description, a tomographic image of a living body as a subject is taken by the image pickup device 4, and a blood vessel 50 (example of a luminal tissue) based on signal values of a plurality of three-dimensional image data obtained by tomography. In order to distinguish from the surrounding blood vessels 98 and 99 described later, a case where a two-dimensional visible image of the blood vessel 50 of interest) is generated will be described as an example.
なお、次述する２次元可視画像の生成手順は、本発明の一実施形態に係る医用画像生成プログラムに従って実行されるものである。また、説明の便宜のために、図３に付記する矢印方向でＸ、ＹおよびＺ方向を定義し、このＸ、ＹおよびＺ方向を併用して以降の説明を行う。 Note that the following two-dimensional visible image generation procedure is executed in accordance with a medical image generation program according to an embodiment of the present invention. For convenience of explanation, the X, Y, and Z directions are defined in the directions of the arrows attached to FIG. 3, and the following explanation will be made using these X, Y, and Z directions together.
〈１〉まず、画像撮像装置４から、被検体である生体を断層撮影して得られた３次元画像データを取得する（画像データ取得ステップ；図２のステップＳ１参照）。このようにして取得された３次元画像データは、画像データ記憶部１２に記憶される。なお、本実施形態では、生体の３次元画像データを画像撮像装置４から取得する構成を想定しているが、この構成に代えて、ＣＤやＤＶＤ等の情報記憶媒体に記憶された３次元画像データを必要に応じて読み出して取得するようにしても良い。 <1> First, three-dimensional image data obtained by tomographic imaging of a living body as a subject is acquired from the image pickup device 4 (image data acquisition step; see step S1 in FIG. 2). The three-dimensional image data acquired in this way is stored in the image data storage unit 12. In the present embodiment, it is assumed that a three-dimensional image data of a living body is acquired from the image capturing device 4, but instead of this configuration, a three-dimensional image stored in an information storage medium such as a CD or a DVD. Data may be read and acquired as necessary.
〈２〉ユーザーが操作装置３を操作することにより、生体の内部組織のうちで２次元表示させて詳細に診断しようとする部位（本実施形態では注目血管５０）が選択され、その選択信号が制御部１１に入力される（選択信号入力ステップ；図２のステップＳ２参照）。ここで図３には、３次元画像データに基づき３次元空間Ｋ３内にイメージされる注目血管５０を示している。この図から分かるように注目血管５０は３次元的に屈曲するようにして走行する。また、この３次元空間Ｋ３内における注目血管５０の周囲には、注目血管５０とは別の周囲血管９８，９９が存在しており、これら周囲血管９８，９９の一部がＺ方向において注目血管５０と重なるように走行する（図５も参照）。 <2> When the user operates the operation device 3, a region (in this embodiment, the target blood vessel 50) to be diagnosed in detail is selected from the internal tissue of the living body, and the selection signal is Input to the control unit 11 (selection signal input step; see step S2 in FIG. 2). Here, FIG. 3 shows a target blood vessel 50 being imaged in 3-dimensional space K 3 based on the three-dimensional image data. As can be seen from this figure, the target blood vessel 50 travels in a three-dimensional manner. In addition, surrounding blood vessels 98 and 99 different from the blood vessel 50 of interest exist around the blood vessel 50 of interest in the three-dimensional space K 3 , and some of these surrounding blood vessels 98 and 99 are of interest in the Z direction. The vehicle travels so as to overlap the blood vessel 50 (see also FIG. 5).
〈３〉ステップＳ１において取得された３次元画像データ、およびステップＳ２において入力された選択信号に基づいて、抽出幅設定手段２１は、注目血管５０の周囲を囲むように３次元空間Ｋ３内に設定される抽出領域ＳＡのＺ方向幅である抽出幅ＳＷを設定する（抽出幅設定ステップ；図２のステップＳ３、図４および図５参照）。ここで、抽出領域ＳＡ内の位置に対応付けられた３次元画像データ（信号値）が、後述するステップＳ５において２次元平面Ｋ２（ＸＹ平面）上に投影される。 <3> 3-dimensional image data acquired in step S1, and based on the input selection signal in step S2, the extraction width setting means 21, in a three-dimensional space K 3 so as to surround the periphery of the target vessel 50 An extraction width SW that is the Z-direction width of the extraction area SA to be set is set (extraction width setting step; see step S3 in FIG. 2, FIG. 4 and FIG. 5). Here, the three-dimensional image data (signal value) associated with the position in the extraction area SA is projected onto the two-dimensional plane K 2 (XY plane) in step S5 described later.
ここで、抽出幅設定手段２１による抽出幅ＳＷの設定例について、図４を参照しながら具体的に説明する。この図４には、抽出幅ＳＷの設定例を２つ示している。１つ目の設定例としての抽出幅設定直線Ａは、注目血管５０における起始部ＳＰからの距離に略反比例するように抽出幅ＳＷを簡易的に設定するための直線である。ここで、起始部ＳＰとは注目血管５０のうちの診断しようとする部分における上流側の所定位置を意味し、末梢部ＥＰとは注目血管５０の下流側端部を意味している。この抽出幅設定直線Ａは、例えば、まず３次元画像データを基にして注目血管５０の芯線５１を算出し、続いて起始部ＳＰにおける血管径と末梢部ＥＰにおける血管径とを算出し、次に起始部ＳＰと末梢部ＥＰとの間の中間部分の血管径が一定の割合で変化するという仮定に基づいて決定される。 Here, an example of setting the extraction width SW by the extraction width setting means 21 will be specifically described with reference to FIG. FIG. 4 shows two setting examples of the extraction width SW. The extraction width setting straight line A as a first setting example is a straight line for simply setting the extraction width SW so as to be approximately inversely proportional to the distance from the starting portion SP in the target blood vessel 50. Here, the starting portion SP means a predetermined position on the upstream side of the portion of the target blood vessel 50 to be diagnosed, and the peripheral portion EP means the downstream end portion of the target blood vessel 50. For this extraction width setting straight line A, for example, the core line 51 of the target blood vessel 50 is first calculated based on the three-dimensional image data, and then the blood vessel diameter in the starting portion SP and the blood vessel diameter in the peripheral portion EP are calculated. Next, it is determined based on the assumption that the blood vessel diameter of the intermediate portion between the starting portion SP and the peripheral portion EP changes at a constant rate.
２つ目の設定例としての抽出幅設定曲線Ｂは、注目血管５０における起始部ＳＰからの距離に略反比例するように抽出幅ＳＷを設定する反比例類似曲線（本明細書では適宜、反比例曲線と称する）である。この抽出幅設定曲線Ｂは、ｘを起始部ＳＰからの距離、ａを湾曲度（曲率に相当する値）を表す係数、ｆ（ｘ）を起始部ＳＰから距離ｘの位置におけるＺ方向（後述するステップＳ５における投影方向）の抽出幅ＳＷとしたとき、以下の式（１）として表される。
ｆ（ｘ）＝ｅｘｐ（−（ａ×ｘ）） （１）
An extraction width setting curve B as a second setting example is an inverse proportional similarity curve (in this specification, an inverse proportional curve is used as appropriate) in which the extraction width SW is set so as to be approximately inversely proportional to the distance from the starting portion SP in the target blood vessel 50. Called). In this extraction width setting curve B, x is a distance from the starting portion SP, a is a coefficient representing a curvature (a value corresponding to a curvature), and f (x) is a Z direction at a position x from the starting portion SP. When the extraction width SW (projection direction in step S5 described later) is used, it is expressed as the following expression (1).
f (x) = exp (− (a × x)) (1)
ところで、生体内には血管に代表される様々な管腔状組織が存在するが、上流側端部（起始部）からの距離に対して管腔状組織の径が式（１）で近似されるものが多く存在し、式（１）を用いることで管腔状組織の径をほぼ反映させた抽出幅ＳＷを設定できる。以上の抽出幅設定直線Ａまたは抽出幅設定曲線Ｂを用いることで、抽出幅ＳＷが、起始部ＳＰからの芯線５１に沿った距離に応じて小さくなるように設定される。なお、抽出幅設定直線Ａおよび抽出幅設定曲線Ｂの決定に際して、血管径以外にも例えば血栓や瘤等の血液の流れに抵抗となる部位がある場合には、この部位も考慮して決定することが好ましい。 By the way, there are various luminal tissues represented by blood vessels in the living body, but the diameter of the luminal tissue is approximated by the equation (1) with respect to the distance from the upstream end (starting part). There is a large amount of the extracted width SW, and the extraction width SW that substantially reflects the diameter of the luminal tissue can be set by using the equation (1). By using the extraction width setting straight line A or the extraction width setting curve B described above, the extraction width SW is set to be smaller according to the distance along the core line 51 from the starting portion SP. In addition, when determining the extraction width setting line A and the extraction width setting curve B, in addition to the blood vessel diameter, for example, if there is a part that resists blood flow, such as a thrombus or an aneurysm, the part is also determined. It is preferable.
〈４〉データ抽出手段２０により、ステップＳ１で取得された３次元画像データから、ステップＳ２で指定された注目血管５０の画像データ群が抽出される（血管部抽出ステップ；図２のステップＳ４参照）。ここで、「注目血管５０の画像データ群」とは、注目血管５０の構造を３次元的に配列された信号値によって表したデータ群である。 <4> The data extraction means 20 extracts the image data group of the target blood vessel 50 specified in step S2 from the three-dimensional image data acquired in step S1 (blood vessel part extraction step; see step S4 in FIG. 2). ). Here, the “image data group of the target blood vessel 50” is a data group in which the structure of the target blood vessel 50 is represented by signal values arranged three-dimensionally.
このステップＳ４における注目血管５０の抽出に際しては、まず、ステップＳ３で設定された抽出幅設定直線Ａまたは抽出幅設定曲線Ｂを用いて、３次元画像データ（信号値）を抽出する領域（抽出領域ＳＡ）を設定する。ここで、例えば抽出幅設定直線Ａを適用した場合には、図５に２点鎖線で示すように、起始部ＳＰからの距離に応じて径が細くなる注目血管５０に対し、その表面に沿うような抽出領域ＳＡのＺ方向における抽出幅ＳＷを設定できる。そのため、注目血管５０とＺ方向に重なる部分を有する周囲血管９８，９９が、注目血管５０に隣接して存在する場合であっても、注目血管５０を含み且つ周囲血管９８，９９を含まない抽出領域ＳＡを設定可能になる。次に、このようにして抽出領域ＳＡが設定された後、この抽出領域ＳＡ内の位置に対応付けられた信号値を抽出することで、周囲血管９８，９９に対応する信号値が注目血管５０に対応する信号値と一緒に抽出されることを防止して、注目血管５０に対応する信号値を抽出できる。 When extracting the target blood vessel 50 in step S4, first, an area (extraction area) for extracting three-dimensional image data (signal value) using the extraction width setting line A or the extraction width setting curve B set in step S3. SA) is set. Here, for example, when the extraction width setting straight line A is applied, as shown by a two-dot chain line in FIG. 5, on the surface of the target blood vessel 50 whose diameter becomes narrower according to the distance from the starting portion SP. The extraction width SW in the Z direction of the extraction area SA along the line can be set. Therefore, even if the surrounding blood vessels 98 and 99 having a portion overlapping with the blood vessel 50 of interest are adjacent to the blood vessel 50 of interest, the extraction including the blood vessel 50 and not including the surrounding blood vessels 98 and 99 is performed. The area SA can be set. Next, after the extraction area SA is set in this way, the signal value corresponding to the position in the extraction area SA is extracted, so that the signal value corresponding to the surrounding blood vessels 98 and 99 is the target blood vessel 50. Thus, the signal value corresponding to the target blood vessel 50 can be extracted.
一方、抽出幅設定曲線Ｂを適用した場合には、図５に示す抽出領域ＳＡと比較して、さらに注目血管５０の表面に接近した抽出幅ＳＷが設定可能になり、この場合にも、注目血管５０を含み且つ周囲血管９８，９９を含まない抽出領域ＳＡを設定できる。そして、このようにして抽出領域ＳＡが設定された後、この抽出領域ＳＡ内の位置に対応付けられた信号値を抽出することで、周囲血管９８，９９に対応する信号値が注目血管５０に対応する信号値と一緒に抽出されることを防止して、注目血管５０に対応する信号値を抽出できる。 On the other hand, when the extraction width setting curve B is applied, the extraction width SW closer to the surface of the target blood vessel 50 can be set as compared with the extraction region SA shown in FIG. An extraction region SA that includes the blood vessel 50 and does not include the surrounding blood vessels 98 and 99 can be set. Then, after the extraction area SA is set in this way, the signal values associated with the positions in the extraction area SA are extracted, so that the signal values corresponding to the surrounding blood vessels 98 and 99 are supplied to the blood vessel 50 of interest. The signal value corresponding to the target blood vessel 50 can be extracted by preventing the signal value from being extracted together with the corresponding signal value.
ところで、従来の医用画像生成装置では、注目血管５０の起始部ＳＰから末梢部ＥＰまでの全体が表示された２次元可視画像を得るために、Ｚ方向の抽出幅を例えば起始部ＳＰに対応させて設定していたため、周囲血管９８，９９の一部を含むように抽出領域が設定される場合があった。これに対し本発明を適用した医用画像生成装置１では、上述したように、図４に示す抽出幅設定直線Ａまたは抽出幅設定曲線Ｂを適用することで、注目血管５０の起始部ＳＰから末梢部ＥＰまでの全体を含みつつ、周囲血管９８，９９を含まないように抽出幅ＳＷ（抽出領域ＳＡ）を設定できる。 By the way, in the conventional medical image generating apparatus, in order to obtain a two-dimensional visible image in which the entire region from the start portion SP to the distal portion EP of the target blood vessel 50 is displayed, the extraction width in the Z direction is set to, for example, the start portion SP. Since they are set in correspondence with each other, the extraction region may be set so as to include a part of the surrounding blood vessels 98 and 99. On the other hand, in the medical image generation apparatus 1 to which the present invention is applied, as described above, the extraction width setting straight line A or the extraction width setting curve B shown in FIG. The extraction width SW (extraction region SA) can be set so as not to include the surrounding blood vessels 98 and 99 while including the entire distal part EP.
〈５〉投影手段２２により、ＣＰＲ表示のうちの例えばStraightenedＣＰＲ法を適用することで、３次元的に折曲した注目血管５０を３次元空間Ｋ３内で伸展させ、その伸展された注目血管５０の信号値を２次元平面Ｋ２上に投影する（投影ステップ；図２のステップＳ５および図６参照）。 <5> By applying, for example, the Straightened CPR method in the CPR display by the projecting means 22, the attention vessel 50 bent three-dimensionally is extended in the three-dimensional space K 3 , and the extension attention vessel 50 is extended. projecting the signal value of the on the two-dimensional plane K 2 (projection step; see step S5 and 6 of FIG. 2).
ここで、２次元平面Ｋ２上への信号値の投影は、具体的には、ステップＳ４で抽出された信号値と２次元平面Ｋ２上の位置とを対応付けることで行われる。このとき、２次元平面Ｋ２に対して垂直な方向（Ｚ方向）に位置する信号値を積算して２次元平面Ｋ２上に投影する方法、Ｚ方向に位置する信号値のうちで最大のものを２次元平面Ｋ２上に投影する方法、および、Ｚ方向に位置する信号値のうちで最小のものを２次元平面Ｋ２上に投影する方法のいずれかによって、信号値の投影が行われる。信号値の投影に関して、上記３方法のうちでいずれを採用するかについては、例えば注目血管５０の特性等に基づき、どの方法で信号値を投影する場合が、注目血管５０の形状を最も忠実に２次元平面Ｋ２上に反映させることができるか等を考慮して決定することが好ましい。 Here, the projection of the signal values of the two-dimensional plane K 2 above is specifically carried out by associating signal values extracted in step S4 and the position on the two-dimensional plane K 2. At this time, a method of projecting by integrating signal values located on the two-dimensional plane K 2 in the direction (Z-direction) perpendicular to the two-dimensional plane K 2, the maximum among the signal values located in the Z-direction method of projecting an object onto a two-dimensional plane K 2, and, by any of the method of projecting the smallest ones on the two-dimensional plane K 2 among the signal values located in the Z direction, the projection of the signal value row Is called. Regarding the projection of the signal value, which of the above three methods is adopted is based on, for example, the characteristics of the blood vessel 50 of interest, and the method of projecting the signal value most faithfully matches the shape of the blood vessel 50 of interest. is preferably determined in consideration of whether or the like can be reflected on the two-dimensional plane K 2.
そして、StraightenedＣＰＲ法を適用して、注目血管５０の芯線５１が画像の中央に位置するように画像を再構築することで、注目血管５０の２次元可視画像が生成される。このように、StraightenedＣＰＲ法を適用した場合には、３次元的に屈曲して走行する注目血管５０が２次元平面Ｋ２上で直線状に伸展されて表示されるので、注目血管５０の読影がしやすくなる。 Then, by applying the Straightened CPR method and reconstructing the image so that the core line 51 of the target blood vessel 50 is located at the center of the image, a two-dimensional visible image of the target blood vessel 50 is generated. Thus, when applying StraightenedCPR method, since attention blood vessel 50 which runs three-dimensionally bent is displayed is extended in a straight line on a two-dimensional plane K 2, the interpretation of interest vessel 50 It becomes easy to do.
上述したように、注目血管５０の表面に沿うように抽出幅ＳＷ（抽出領域ＳＡ）を設定し、この抽出領域ＳＡに基づいて抽出された信号値が投影されて２次元可視画像が生成されるので、注目血管５０の起始部ＳＰから末梢部ＥＰまでの全体が表示された２次元可視画像を得ることができる。ここで、投影される信号値の中に、周囲血管９８，９９に対応する信号値が含まれていないので、注目血管５０の正確な２次元可視画像を生成可能になる。 As described above, the extraction width SW (extraction area SA) is set along the surface of the target blood vessel 50, and the signal value extracted based on the extraction area SA is projected to generate a two-dimensional visible image. Therefore, it is possible to obtain a two-dimensional visible image in which the whole of the blood vessel 50 of interest from the start part SP to the peripheral part EP is displayed. Here, since the signal values to be projected do not include signal values corresponding to the surrounding blood vessels 98 and 99, an accurate two-dimensional visible image of the blood vessel 50 of interest can be generated.
〈６〉ステップＳ５において生成された注目血管５０の２次元可視画像を、制御部１１から画像表示装置２へ出力する（２次元可視画像出力ステップ；図２のステップＳ６参照）。こうすることで、周囲血管９８，９９に対応する信号値の影響が排除された注目血管５０の２次元可視画像が画像表示装置２に表示され、この２次元可視画像を読影することで、注目血管５０の形状や異常箇所の有無等を正確に把握することができ、誤診の可能性が大幅に低減される。この２次元可視画像出力ステップが実行されることで、このフローは終了する。 <6> The two-dimensional visible image of the target blood vessel 50 generated in step S5 is output from the control unit 11 to the image display device 2 (two-dimensional visible image output step; see step S6 in FIG. 2). By doing this, a two-dimensional visible image of the target blood vessel 50 from which the influence of the signal values corresponding to the surrounding blood vessels 98 and 99 has been eliminated is displayed on the image display device 2, and the two-dimensional visible image is read, so that attention is paid. It is possible to accurately grasp the shape of the blood vessel 50 and the presence / absence of an abnormal portion, and the possibility of misdiagnosis is greatly reduced. This flow ends when this two-dimensional visible image output step is executed.
以上、本発明の一実施形態について説明したが、本発明は上記実施形態に限定されるものではなく、種々に態様を変更することが可能である。 As mentioned above, although one Embodiment of this invention was described, this invention is not limited to the said embodiment, A mode can be changed variously.
上述の実施形態においては、StraightenedＣＰＲ法を適用して２次元可視画像を生成する場合を例示したが、このStraightenedＣＰＲ法に代えて、例えばProjectedＣＰＲ法やStretchedＣＰＲ法を適用して２次元可視画像を生成することも可能である。 In the above-described embodiment, the case where the 2D visible image is generated by applying the Straightened CPR method is exemplified. However, instead of the Straightened CPR method, for example, the Projected CPR method or the Stretched CPR method is applied to generate the 2D visible image. It is also possible.
上述の実施形態においては、本発明を適用した医用画像生成装置１を用いて、管腔状組織の一例としての注目血管５０の２次元可視画像を生成する場合を例示して説明したが、医用画像生成装置１は血管以外の２次元可視画像を生成することも可能である。すなわち、例えば腸管、膵管、胆管、リンパ管、気管等の他の管腔状組織の２次元可視画像を生成することも可能である。 In the above-described embodiment, the case where a two-dimensional visible image of the blood vessel 50 of interest as an example of a tubular tissue is generated by using the medical image generation apparatus 1 to which the present invention is applied has been described as an example. The image generation device 1 can also generate a two-dimensional visible image other than blood vessels. That is, for example, it is also possible to generate a two-dimensional visible image of other luminal tissues such as the intestinal tract, pancreatic duct, bile duct, lymphatic duct, and trachea.
上述の実施形態では、主としてＣＴ装置またはＭＲＩ装置により得られた画像データを用いる場合について説明しているが、本発明はこれに限定されるものではなく、他の画像撮像装置により得られた３次元画像データを用いて、診断に好適な２次元可視画像を生成することも可能である。 In the above-described embodiment, the case where image data obtained mainly by a CT apparatus or an MRI apparatus is used has been described. However, the present invention is not limited to this, and 3 obtained by another image imaging apparatus. It is also possible to generate a two-dimensional visible image suitable for diagnosis using the two-dimensional image data.
上述の実施形態では、式（１）で規定される抽出幅設定曲線Ｂを用いて抽出幅ＳＷを設定される例について説明したが、抽出幅ＳＷを設定する反比例曲線はこの例に限定されない。例えば、ｘを起始部ＳＰからの距離、ｆ（ｘ）を起始部ＳＰから距離ｘの位置における投影方向の抽出幅ＳＷとしたとき、以下の式（２）で規定される反比例曲線を用いて抽出幅ＳＷを設定することが可能である。
ｆ（ｘ）＝１／ｅｘｐ（ｘ） （２）
また、ｘを起始部ＳＰからの距離、ｍを正の整数、ｆ（ｘ）を起始部ＳＰから距離ｘの位置における投影方向の抽出幅ＳＷとしたとき、以下の式（３）で規定される反比例曲線を用いて抽出幅ＳＷを設定することも可能である。
ｆ（ｘ）＝１／ｘｍ （３）
In the above-described embodiment, the example in which the extraction width SW is set using the extraction width setting curve B defined by Expression (1) has been described, but the inverse proportional curve for setting the extraction width SW is not limited to this example. For example, when x is a distance from the starting part SP and f (x) is an extraction width SW in the projection direction at a position x from the starting part SP, an inverse proportional curve defined by the following equation (2) is obtained. It is possible to set the extraction width SW.
f (x) = 1 / exp (x) (2)
Further, when x is a distance from the starting portion SP, m is a positive integer, and f (x) is an extraction width SW in the projection direction at a position x from the starting portion SP, the following equation (3) is satisfied. It is also possible to set the extraction width SW using a prescribed inverse proportional curve.
f (x) = 1 / x m (3)
上述の実施形態では、Ｚ方向への抽出幅ＳＷを起始部ＳＰからの距離に略反比例させて設定する方法について説明をした。ところで、信号値が投影される面（２次元平面Ｋ２）に対して平行な面内における抽出幅の設定方法に関しては、例えば起始部に対応した抽出幅を設定する方法や、Ｚ方向への抽出幅と同様に、起始部ＳＰからの距離に略反比例させて設定する方法を採用できる。 In the above-described embodiment, the method for setting the extraction width SW in the Z direction so as to be approximately inversely proportional to the distance from the starting portion SP has been described. By the way, regarding the method for setting the extraction width in a plane parallel to the plane (two-dimensional plane K 2 ) on which the signal value is projected, for example, a method for setting the extraction width corresponding to the starting portion, or in the Z direction. As in the case of the extraction width, a method in which the distance is set approximately inversely proportional to the distance from the starting portion SP can be employed.
１ 医用画像生成装置
２ 画像表示装置
３ 操作装置
４ 画像撮像装置（医用画像撮像装置）
１１ 制御部
１２ 画像データ記憶部
１３ 可視画像記憶部
１４ 可視画像出力インタフェース
１５ 操作入力インタフェース
１６ 画像データ入力インタフェース
２０ データ抽出手段
２１ 抽出幅設定手段
２２ 投影手段
５０ 血管、注目血管
５１ 芯線
９８ 周囲血管
９９ 周囲血管
Ａ 抽出幅設定直線
Ｂ 抽出幅設定曲線
ＥＰ 末梢部
Ｋ２ ２次元平面
Ｋ３ ３次元空間
ＳＡ 抽出領域
ＳＰ 起始部
ＳＷ 抽出幅
DESCRIPTION OF SYMBOLS 1 Medical image generation apparatus 2 Image display apparatus 3 Operation apparatus 4 Image imaging device (medical image imaging device)
DESCRIPTION OF SYMBOLS 11 Control part 12 Image data memory | storage part 13 Visible image memory | storage part 14 Visible image output interface 15 Operation input interface 16 Image data input interface 20 Data extraction means 21 Extraction width setting means 22 Projection means 50 Blood vessel, attention blood vessel 51 Core wire 98 Peripheral blood vessel 99 perivascular A extraction width setting line B extraction width setting curve EP periphery K 2 2-dimensional plane K 3 3 dimensional space SA extraction region SP proximal portion SW extraction width
Claims (7)
投影方向における前記管腔状組織の３次元医用画像データの抽出幅を、該管腔状組織における芯線の所定位置からの該芯線に沿った距離に応じ変化させて設定する抽出幅設定手段を備えたことを特徴とする医用画像生成装置。 3D medical image data of a tubular tissue is extracted with a predetermined extraction width from 3D medical image data acquired by imaging with a medical image imaging device, and the extracted 3D medical image of the tubular tissue is extracted. A medical image generation apparatus for projecting data onto a predetermined plane in an image space and generating a two-dimensional observation image of the tubular tissue,
Extraction width setting means is provided for setting the extraction width of the three-dimensional medical image data of the tubular tissue in the projection direction in accordance with the distance along the core line from a predetermined position of the core line in the tubular tissue. A medical image generation apparatus characterized by that.
ｆ（ｘ）＝ｅｘｐ（−（ａ×ｘ））
ここで、ｘは前記距離であって正の値、ａは係数、ｆ（ｘ）は該距離がｘの位置における前記投影方向の抽出幅である。 The medical image generation apparatus according to claim 1, wherein the extraction width setting unit sets the extraction width so as to satisfy the following expression.
f (x) = exp (− (a × x))
Here, x is the distance and is a positive value, a is a coefficient, and f (x) is the extraction width in the projection direction at the position where the distance is x.
前記StraightenedＣＰＲ法により、前記管腔状組織の信号値を前記投影方向に積算して前記所定の平面上に投影する、該投影方向における該管腔状組織の最大信号値を該所定の平面上に投影する、または該投影方向における該管腔状組織の最小信号値を該所定の平面上に投影することを特徴とする請求項１〜４のいずれか１項記載の医用画像生成装置。 3D medical image data of the tubular tissue is configured to be projected onto the predetermined plane by a Straightened CPR method,
According to the Straightened CPR method, the signal value of the tubular tissue is integrated in the projection direction and projected onto the predetermined plane, and the maximum signal value of the tubular tissue in the projection direction is projected onto the predetermined plane. The medical image generating apparatus according to claim 1, wherein the medical image generating apparatus projects or projects a minimum signal value of the tubular tissue in the projection direction onto the predetermined plane.
投影方向における前記管腔状組織の３次元医用画像データの抽出幅を、該管腔状組織における芯線の所定位置からの該芯線に沿った距離に応じ変化させて設定する抽出幅設定ステップをコンピュータにおいて実行せしめることを特徴とする医用画像生成プログラム。 3D medical image data of a tubular tissue is extracted with a predetermined extraction width from 3D medical image data acquired by imaging with a medical image imaging device, and the extracted 3D medical image of the tubular tissue is extracted. A medical image generation program for projecting data on a predetermined plane in an image space and causing a computer to execute a process of generating a two-dimensional observation image of the tubular tissue,
An extraction width setting step for setting the extraction width of the three-dimensional medical image data of the tubular tissue in the projection direction in accordance with the distance along the core line from a predetermined position of the core line in the tubular tissue. A medical image generation program characterized in that the program is executed.
投影方向における前記管腔状組織の３次元医用画像データの抽出幅を、該管腔状組織における芯線の所定位置からの該芯線に沿った距離に応じ変化させて設定する抽出幅設定処理を行うことを特徴とする医用画像生成方法。 3D medical image data of a tubular tissue is extracted with a predetermined extraction width from 3D medical image data acquired by imaging with a medical image imaging device, and the extracted 3D medical image of the tubular tissue is extracted. A medical image generation method for projecting data onto a predetermined plane in an image space and generating a two-dimensional observation image of the tubular tissue,
An extraction width setting process is performed in which the extraction width of the three-dimensional medical image data of the tubular tissue in the projection direction is set in accordance with the distance along the core line from a predetermined position of the core line in the tubular tissue. A medical image generation method characterized by the above.
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