JP2013035803A - Persimmon fruit powder composition having blood sugar reducing effect - Google Patents
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Abstract
Description
本発明は、血糖値低下効果を有する柿果実粉末組成物に関する。より詳しくは、柿、特に未成熟柿果実を原料として、乾燥、水可溶性成分を除去し、粉末化する工程より得られる血糖値低下効果を有する柿果実粉末組成物、並びに該柿果実粉末組成物を含有する機能食品、糖尿病治療剤又は血糖値低下治療剤に関する。 The present invention relates to a strawberry fruit powder composition having a blood glucose level lowering effect. More specifically, cocoon fruit powder composition having a blood glucose level-lowering effect obtained from the step of drying, removing water-soluble components and pulverizing from strawberry, especially immature strawberry fruit, and the strawberry fruit powder composition The present invention relates to a functional food, a therapeutic agent for diabetes, or a therapeutic agent for lowering blood glucose level.
日本人は欧米人と比較してインスリン分泌量が半分程度であり、肥満を伴わなくても糖尿病になりやすい性質を有している。平成19年度の国民健康・栄養調査によると糖尿病患者は予備軍を含めると2210万人と推定されており、その医療費は平成9年度に1兆円を超え、平成12年度以降は1兆1千億円を超えた状態が続いている（厚生労働省統計より）。
糖尿病患者の増加は国民の健康に関する観点だけでなく国民医療費の観点からも問題となっている。
しかしながら糖尿病は自覚症状がほとんどないため、症状が現れた時点では白内障や糖尿病性腎症など手遅れとなることが多く、日頃の食事の管理や定期的な運動など予防が重要視されている。
糖尿病の予防手段として、積極的な機能性食品の活用は有効であり、食後血糖値の上昇を緩やかにする難消化性多糖類（参照：特許文献１、２）及び糖分解酵素阻害剤が報告されている。
Japanese people have about half the amount of insulin secretion compared to Westerners, and they are prone to diabetes without obesity. According to the National Health and Nutrition Survey in 2007, the number of diabetic patients is estimated to be 22.1 million including the reserve army, and the medical expenses exceeded 1 trillion yen in 1997, and 1 trillion in 2000 and beyond. The situation has exceeded 100 billion yen (according to Ministry of Health, Labor and Welfare statistics).
The increase in patients with diabetes is a problem not only from the viewpoint of public health but also from the viewpoint of national medical expenses.
However, since diabetes has almost no subjective symptoms, cataracts and diabetic nephropathy are often delayed when symptoms appear, and prevention of daily dietary management and regular exercise is regarded as important.
As a means of preventing diabetes, active use of functional foods is effective, and indigestible polysaccharides (see Patent Documents 1 and 2) and glycolytic enzyme inhibitors that moderate postprandial blood glucose level increase are reported. Has been.
これまで開発された糖尿病予防効果を有する機能性食品は、動物実験やヒト介入試験で効果が示されているものの、単回投与試験による血糖値上昇抑制や数週間程度での試験における有効性を示すものが多く、医学的観点からは有効性に疑問が生じる商品が少なくない。 Functional foods with diabetes prevention effects developed so far have been shown to be effective in animal experiments and human intervention studies, but have been shown to be effective in single-dose studies in suppressing blood glucose elevation and in tests in several weeks. There are many things to show, and from a medical point of view, there are many products that have doubts about their effectiveness.
一方、最近の柿の研究により、柿由来の組成物が骨粗鬆予防効果、アディポネクチン産出促進効果、コレステロール低下効果等が報告されている（参照：特許文献３〜６）。 On the other hand, recent studies on hemorrhoids have reported that the composition derived from hemorrhoids has an effect of preventing osteoporosis, an effect of promoting adiponectin production, an effect of lowering cholesterol, and the like (see Patent Documents 3 to 6).
柿由来の組成物に関する報告の詳細は、以下の通りである。
特許文献３は、「柿果実の画分、それを含む胆汁酸吸着剤、ＬＤＬ-コレステロール低下剤、及び栄養補助食品、柿果実加工品の製造方法、胆汁酸吸着方法、並びにＬＤＬ-コレステロール低下方法」を開示している。
特許文献４は、「柿果皮由来の骨粗鬆症予防組成物」を開示している。
特許文献５は、「安全で且つ経済的で、摂取しやすいアディポネクチン産生促進剤」を開示している。
特許文献６は、「成熟２週間前までの間に摘果された未成熟柿果実を乾燥後、粉砕した未成熟柿果実粉末組成物の製造方法、及び該未成熟柿果実粉末組成物を含有する脂質代謝改善剤、または胆汁酸の排泄促進剤」を開示している。
The details of the report regarding the composition derived from strawberries are as follows.
Patent Document 3 states that “a fraction of persimmon fruit, a bile acid adsorbent containing the same, a LDL-cholesterol lowering agent, and a nutritional supplement, a method for producing a persimmon fruit processed product, a bile acid adsorption method, and a LDL-cholesterol lowering method Is disclosed.
Patent Document 4 discloses “a composition for preventing osteoporosis derived from pericarp”.
Patent Document 5 discloses a “safe and economical adiponectin production promoter that is easy to take”.
Patent Document 6 states that “a method for producing a powdered composition of immature persimmon fruit dried after 2 weeks before maturation and pulverized immature persimmon fruit powder composition, and improvement of lipid metabolism containing the immature persimmon fruit powder composition” Agent or bile acid excretion enhancer ".
上記いずれの文献は、「血糖値低下効果」について開示又は示唆がない。 None of the above references discloses or suggests a “blood glucose level lowering effect”.
また、一般的な柿栽培では、１本の樹木に多くの柿を実らせると、果実が小玉化して商品価値が下がることから、成熟果実を大玉化して商品価値を上げるために、柿の成長過程における各段階において、「摘蕾」や「摘果」作業が行われている。
該摘果作業等で取り除かれた大量の未成熟果実は、特に他の用途もなく、廃棄処分されていたので、これらを有効利用することが望まれていた。
Also, in general cocoon cultivation, if many berries grow on one tree, the fruit becomes small and the product value decreases. At each stage of the process, “plucking” and “plucking” operations are performed.
Since a large amount of immature fruit removed by the fruit picking operation or the like has been disposed of without any other use, it has been desired to effectively use them.
本発明は、上記した問題点を解決することを解決すべき課題とした。より詳しくは、新規な血糖値低下効果を有する柿由来の組成物を提供することを解決すべき課題とした。 This invention made it the subject which should solve solving the above-mentioned problem. More specifically, an object of the present invention is to provide a novel composition derived from sputum having a blood glucose level lowering effect.
本発明者らは、「柿果実を原料とし、該柿果実を乾燥し、一部又は全部の水可溶性成分を除去し、さらに粉末化する工程より得られる柿果実粉末組成物は血糖値低下効果を有すること」を見出したことを基にして、本発明を完成した。 The inventors of the present invention have described, “The strawberry fruit powder composition obtained from the step of using strawberry fruit as a raw material, drying the strawberry fruit, removing some or all of the water-soluble components, and further pulverizing the blood sugar level reducing effect The present invention has been completed on the basis of the finding of “having”.
すなわち、本発明は以下の通りである。
「１．柿果実から得られた水不溶の縮合型タンニンを有効成分とする血糖値低下効果を有する組成物。
２．柿果実を原料とし、該柿果実を乾燥し、一部又は全部の水可溶性成分を除去し、さらに粉末化する工程より得られる柿果実粉末由来の前項１の組成物。
３．前記組成物の糖質が1.0〜15.0重量％及び食物繊維が55.0〜95.0重量%であることを特徴とする前項１又は２の組成物。
４．柿果実を原料とし、該柿果実を乾燥し、一部又は全部の水可溶性成分を除去し、さらに粉末化する工程より得られる血糖値低下効果を有する柿果実粉末組成物であって、該粉末組成物の糖質が1.0〜15.0重量％及び食物繊維が55.0〜95.0重量%であることを特徴とする前項２又は３の組成物。
５．前記組成物の割合が以下である前項１〜４のいずれか１に記載の組成物：
（１）食物繊維が80.0〜93.0重量%であり、ここで、該食物繊維中の縮合型タンニンが5.0〜40.0重量％である；
（２）水分が1.0〜13.0重量%である；
（３）タンパク質が2.0〜6.0重量%である；
（４）脂質が0.1〜3.0重量％である；
（５）灰分が0.1〜3.0重量％である；
（６）糖質が1.0〜15.0重量％である。
６．前記組成物が糖尿病治療、予防又は改善用組成物である、前項１〜５のいずれか１に記載の組成物。
７．前項１〜６のいずれか１に記載の組成物を含有することを特徴とする血糖値低下治療剤。
８．前項１〜６のいずれか１に記載の組成物を含有することを特徴とする糖尿病治療剤。
９．前項１〜６のいずれか１に記載の組成物を含有することを特徴とする機能性食品。」
That is, the present invention is as follows.
“1. A composition having a blood glucose level-lowering effect comprising water-insoluble condensed tannin obtained from strawberries as an active ingredient.
2. The composition according to item 1 above, derived from a koji fruit powder obtained from a step of drying koji fruit, removing a part or all of the water-soluble components, and further pulverizing.
3. The composition according to item 1 or 2 above, wherein the saccharide in the composition is 1.0 to 15.0% by weight and the dietary fiber is 55.0 to 95.0% by weight.
4). A strawberry fruit powder composition having a blood glucose level-lowering effect obtained from a process of using strawberry fruit as a raw material, drying the strawberry fruit, removing a part or all of water-soluble components, and further pulverizing the powder. The composition according to item 2 or 3 above, wherein the sugar content of the composition is 1.0 to 15.0% by weight and the dietary fiber is 55.0 to 95.0% by weight.
5. The composition according to any one of the preceding items 1 to 4, wherein the ratio of the composition is as follows:
(1) dietary fiber is 80.0-93.0 wt%, where condensed tannin in the dietary fiber is 5.0-40.0 wt%;
(2) Moisture is 1.0-13.0% by weight;
(3) The protein is 2.0-6.0% by weight;
(4) The lipid is 0.1 to 3.0% by weight;
(5) Ash content is 0.1 to 3.0% by weight;
(6) Carbohydrate is 1.0 to 15.0% by weight.
6). 6. The composition according to any one of items 1 to 5, wherein the composition is a composition for treating, preventing or improving diabetes.
7). A therapeutic agent for lowering blood glucose level, comprising the composition according to any one of items 1 to 6.
8). A therapeutic agent for diabetes comprising the composition according to any one of items 1 to 6 above.
9. A functional food comprising the composition according to any one of items 1 to 6 above. "
本発明の未成熟柿果実粉末組成物は、優れた血糖値低下効果を示した。 The immature persimmon fruit powder composition of the present invention showed an excellent blood glucose level lowering effect.
（柿果実粉末組成物の製造方法）
本発明の柿果実粉末組成物の製造方法の概要は、以下の通りである。しかしながら、下記で記載する成分割合の柿果実粉末組成物を製造できるのであれば製造方法は特に限定されない。
（１）柿果実を乾燥する工程
（２）一部又は全部の水可溶性成分を上記（１）の乾燥柿果実から除去する工程
（３）上記（２）の一部又は全部の水可溶性成分が除去された乾燥柿果実を粉末化する工 程
さらに、好ましくは、上記（１）の乾燥工程前に、スライス又は短冊状に細断する工程、及び／又は上記（３）の粉末化する工程前に、乾燥工程を含む。
(Manufacturing method of persimmon fruit powder composition)
The outline | summary of the manufacturing method of the strawberry fruit powder composition of this invention is as follows. However, the production method is not particularly limited as long as it can produce a koji fruit powder composition having the component ratio described below.
(1) Step of drying strawberries (2) Step of removing some or all water-soluble components from dried strawberries of (1) (3) Part or all of the water-soluble components of (2) above Process of pulverizing the dried dried persimmon fruit More preferably, prior to the drying step of (1) above, the step of slicing into slices or strips, and / or the step of pulverizing (3) above In addition, a drying step is included.
（柿果実）
柿果実は、未成熟果でもよく、成熟果でもよいが、タンニン含有量が高い未成熟果が好ましい。また、柿果実は、へたを除いた柿果実の全体をそのまま用いてもよく、具体的には、へたを除いた果肉、果皮、及び種子の何れも用いることができるが、作業効率が良い点で、へたを除いた柿果実の全体をそのまま用いるのが好ましい。
なお、柿果実における成熟柿と未成熟柿との判別については、特に明確な基準はないが、収穫の２週間以上前に摘果されたものを未成熟果実とする。
柿の品種は、特に限定されないが、例えば、蜂屋柿、平核無、四溝、富有、刀根早生柿、次郎、西村早生、愛秋豊、筆柿、太秋、新秋、甲州百日、市田柿、横野、西条柿、花御所、愛宕、紅柿等が挙げられる。
(Strawberry fruit)
The persimmon fruit may be an immature fruit or a mature fruit, but an immature fruit having a high tannin content is preferred. In addition, as for the strawberry fruit, the whole strawberry fruit excluding the spatula may be used as it is, and specifically, any of the flesh, the skin and the seed excluding the spatula can be used. In terms of good points, it is preferable to use the whole strawberry fruit excluding spatula as it is.
In addition, although there is no clear standard about discrimination | determination between the matured cocoon and the immature cocoon in a strawberry fruit, what was picked more than two weeks before harvest is made into an immature fruit.
There are no particular limitations on the varieties of cocoons, but for example, bee pods, plain cores, four grooves, Fuyu, Tone Sayaka, Jiro, Nishimura Saya, Ai Yutaka, Japanese sword, Taiki, New Autumn, Koshu Hundred Days, Examples include Ichida Pass, Yokono, Saijo Pass, Hana Gosho, Ehime, Kurisu.
（乾燥工程）
乾燥は、自然乾燥、送風乾燥、減圧乾燥、凍結乾燥、遠赤外線乾燥を含む公知の果実乾燥方法が利用可能である。
乾燥温度は、糖の褐変による変色を防ぐため、通常約80℃以下とすればよく、好ましくは約70℃以下、より好ましくは約60℃以下が好ましい。
乾燥時間は、約１〜２０時間、好ましくは５〜１５時間、より好ましくは７〜１３時間である。
(Drying process)
For drying, known fruit drying methods including natural drying, air drying, reduced pressure drying, freeze drying, and far infrared drying can be used.
In order to prevent discoloration due to browning of sugar, the drying temperature is usually about 80 ° C. or less, preferably about 70 ° C. or less, more preferably about 60 ° C. or less.
The drying time is about 1 to 20 hours, preferably 5 to 15 hours, more preferably 7 to 13 hours.
（水可溶性成分の除去工程）
水可溶性成分の除去方法は、乾燥した柿果実から全部又は一部の糖質、可溶性ポリフェノール、水溶性タンニンを除去できれば特に限定されない。好ましくは、流水等により水可溶性成分を洗い流す。
詳しくは、柿果実乾燥物を一定量の水中に浸漬し、さらに必要に応じて撹拌し、又は流水状態にさらすことにより、水可溶性成分を水中に除去することにより得られる。
水の温度は、0〜100℃であり、好ましくは10〜60℃であり、より好ましくは20〜50℃である。
処理時間は、5〜60分間であり、好ましくは15〜60分間である。
水の使用量は、柿果実１質量部に対して10〜2000質量部であり、好ましくは100〜1000質量部である。
(Removal process of water-soluble components)
The method for removing the water-soluble component is not particularly limited as long as all or part of the sugar, soluble polyphenol, and water-soluble tannin can be removed from the dried persimmon fruit. Preferably, the water-soluble component is washed away with running water or the like.
Specifically, it is obtained by immersing a dried fruit product in a certain amount of water, further stirring as necessary, or exposing it to running water to remove water-soluble components in water.
The temperature of water is 0-100 ° C, preferably 10-60 ° C, more preferably 20-50 ° C.
The treatment time is 5 to 60 minutes, preferably 15 to 60 minutes.
The usage-amount of water is 10-2000 mass parts with respect to 1 mass part of strawberry fruits, Preferably it is 100-1000 mass parts.
（粉末化工程）
粉砕は、ミキサー、粉砕機、ボールミル、ハンマーミル、ロールクラッシャー、石臼式、押出・剪定式等の公知の手段で行うことができる。
本発明の柿果実粉末組成物の粒子径は、10〜1000μm、好ましくは50〜500μm、より好ましくは80〜200μmである。
(Powdering process)
The pulverization can be performed by a known means such as a mixer, a pulverizer, a ball mill, a hammer mill, a roll crusher, a stone mortar type, an extrusion / pruning type.
The particle size of the koji fruit powder composition of the present invention is 10 to 1000 μm, preferably 50 to 500 μm, more preferably 80 to 200 μm.
（柿果実粉末組成物の成分割合）
本発明の柿果実粉末組成物の成分割合は、食物繊維が55.0〜95.0重量%及び糖質が1.0〜15.0重量％であることを特徴とする。
より詳しい成分割合は、以下の通りである。
食物繊維が80.0〜93.0重量%であり、ここで、該食物繊維中の縮合型タンニンが5.0〜40.0重量％である。
水分が1.0〜13.0重量%である。
タンパク質が2.0〜6.0重量%である。
脂質が0.1〜3.0重量％である。
灰分が0.1〜3.0重量％である。
糖質が1.0〜15.0重量％である。
本発明の柿果実粉末組成物は、従来の柿果実粉末組成物と比較して、食物繊維割合が高く、糖質が低い。
さらに、本発明者らは、本発明の柿果実粉末組成物中には水溶性タンニンがほとんど存在していないことを確認している。
(Ingredient ratio of persimmon fruit powder composition)
The component ratio of the strawberry fruit powder composition of the present invention is characterized in that the dietary fiber is 55.0-95.0% by weight and the sugar is 1.0-15.0% by weight.
More detailed component ratios are as follows.
Dietary fiber is 80.0-93.0 wt%, where condensed tannin in the dietary fiber is 5.0-40.0 wt%.
The water content is 1.0-13.0% by weight.
Protein is 2.0-6.0% by weight.
The lipid is 0.1-3.0% by weight.
Ash content is 0.1-3.0 wt%.
Carbohydrate is 1.0-15.0% by weight.
The strawberry fruit powder composition of the present invention has a high dietary fiber ratio and a low sugar content as compared with the conventional strawberry fruit powder composition.
Furthermore, the present inventors have confirmed that there is almost no water-soluble tannin in the strawberry fruit powder composition of the present invention.
（本発明の治療剤）
本発明の柿果実粉末組成物を含む治療剤は、下記実施例２及び３の結果により、血糖値低下効果、糖尿病治療効果、糖尿病予防効果及び糖尿病改善効果を有する。
加えて、本発明の治療剤は、各種の経口投与形態を有する製剤とすることができる。固形製剤としては、例えば散剤、顆粒剤、錠剤、タブレット剤、丸剤、カプセル剤、チュアブル剤などが挙げられる。液体製剤としては、乳剤、液剤、シロップ剤等が挙げられる。
(Therapeutic agent of the present invention)
The therapeutic agent containing the strawberry fruit powder composition of the present invention has a blood glucose level lowering effect, a diabetes treatment effect, a diabetes prevention effect, and a diabetes improvement effect according to the results of Examples 2 and 3 below.
In addition, the therapeutic agent of the present invention can be made into preparations having various oral dosage forms. Examples of solid preparations include powders, granules, tablets, tablets, pills, capsules, chewable agents and the like. Examples of liquid preparations include emulsions, solutions, syrups and the like.
本発明の治療剤中の柿果実粉末組成物の含有量は、乾燥質量に換算して、1.0〜95.0質量％、好ましくは10〜80質量％、より好ましくは15〜65質量%である。
また、本発明の治療剤の１日の使用量は、対象者の症状、体重などによっても異なるが、有効成分である柿果実粉末組成物の乾燥重量に換算した１日使用量が、0.1〜60g、好ましくは1〜50g、より好ましくは5〜40gである。
The content of the strawberry fruit powder composition in the therapeutic agent of the present invention is 1.0 to 95.0% by mass, preferably 10 to 80% by mass, more preferably 15 to 65% by mass in terms of dry mass.
Moreover, although the daily usage amount of the therapeutic agent of this invention changes also with a subject's symptom, a body weight, etc., the daily usage amount converted into the dry weight of the strawberry fruit powder composition which is an active ingredient is 0.1- 60 g, preferably 1 to 50 g, more preferably 5 to 40 g.
（本発明の機能性食品）
本発明の柿果実粉末組成物を含む機能性食品は、下記実施例２及び３の結果により、血糖値低下効果、糖尿病治療効果、糖尿病予防効果、糖尿病改善効果を有する。
本発明の機能性食品は、食品に通常用いられる賦形剤または添加剤を配合して、錠剤、タブレット剤、丸剤、顆粒剤、散剤、粉剤、カプセル剤、水和剤、乳剤、液剤、エキス剤、またはエリキシル剤などの剤型に調製することができる。
(Functional food of the present invention)
The functional food containing the strawberry fruit powder composition of the present invention has a blood glucose level lowering effect, a diabetes treatment effect, a diabetes prevention effect, and a diabetes improvement effect according to the results of Examples 2 and 3 below.
The functional food of the present invention is blended with excipients or additives usually used in foods, tablets, tablets, pills, granules, powders, powders, capsules, wettable powders, emulsions, liquids, It can be prepared in a dosage form such as an extract or an elixir.
本発明の機能性食品中の柿果実粉末組成物の含有量は、乾燥質量に換算して、1〜95質量％、好ましくは10〜80質量％、より好ましくは15〜65質量%である。
また、本発明の機能性食品の１日の使用量は、対象者の症状、体重などによっても異なるが、有効成分である柿果実粉末組成物の乾燥重量に換算した１日使用量が0.1〜60g、好ましくは1〜50g、より好ましくは5〜40gである。
また、本発明の機能性食品は、一般の飲料、食品、調味料の組成物であってもよい。
The content of the strawberry fruit powder composition in the functional food of the present invention is 1 to 95% by mass, preferably 10 to 80% by mass, more preferably 15 to 65% by mass in terms of dry mass.
Moreover, although the daily usage-amount of the functional food of this invention changes also with a subject's symptom, a body weight, etc., the daily usage-equivalent to the dry weight of the strawberry fruit powder composition which is an active ingredient is 0.1- 60 g, preferably 1 to 50 g, more preferably 5 to 40 g.
The functional food of the present invention may be a general beverage, food, or seasoning composition.
以下、本発明を、実施例を挙げてより詳細に説明するが、本発明はこれらに限定されるものではない。 EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited to these.
（柿果実粉末組成物の製造及び該組成物の成分分析）
本発明の柿果実粉末組成物を以下の方法で製造して、さらに製造した組成物の成分を分析した。詳細は、以下の通りである。
(Production of strawberry fruit powder composition and component analysis of the composition)
The strawberry fruit powder composition of the present invention was produced by the following method, and the components of the produced composition were analyzed. Details are as follows.
（柿果実粉末組成物の製造）
開花後80日以内（収穫の8週間前）に摘果された未成熟の平核無柿果実を用いた。へたを除いた柿果実1ｋｇを短冊状に裁断して、遠赤外線乾燥機（ヴィアノーベ社製）により、60℃で20時間乾燥させた。得られた、柿果実乾燥物（約0.15ｋｇ）を流水により３０分間処理し（約150Ｌの水道水を利用）、水洗を行った。水洗した柿果実は、脱水機（日本ゼネラル・アプライアンス社製）により脱水し、遠赤外線乾燥機（ヴィアノーベ社製）により、60℃で20時間乾燥させた。乾燥した柿果実を、ミルミキサー（大阪ケミカル社製）により粉末状に粉砕し、本発明の柿果実粉末組成物を得た。
(Manufacture of strawberry fruit powder composition)
Immature plain-nucleated unripe fruits that were harvested within 80 days after flowering (8 weeks before harvest) were used. 1 kg of persimmon fruit excluding the spatula was cut into strips and dried at 60 ° C. for 20 hours with a far-infrared dryer (manufactured by Via Nove). The obtained dried fruit product (about 0.15 kg) was treated with running water for 30 minutes (using about 150 L of tap water) and washed with water. The fruit fruits washed with water were dehydrated with a dehydrator (manufactured by Nippon General Appliances) and dried at 60 ° C. for 20 hours with a far-infrared dryer (manufactured by Via Nove). The dried persimmon fruit was pulverized into powder by a mill mixer (manufactured by Osaka Chemical Co., Ltd.) to obtain the persimmon fruit powder composition of the present invention.
（柿果実粉末組成物の分析）
上記の柿果実粉末組成物中の各成分の分析は、日本食品分析センターに依頼して行った。
また、柿果実粉末組成物2ｇを用いて80℃、30分間メタノール塩酸溶液（メタノール70％、濃塩酸1％）200ml（100mlX2回）で縮合型タンニンを抽出し、抽出液に対しバニリン塩酸法を行い、カテキンを標準物質として縮合型タンニン量を算出した（なお、縮合型タンニンは、分析上、食物繊維に含まれる）。
(Analysis of strawberry fruit powder composition)
The analysis of each component in said strawberry fruit powder composition was performed by requesting the Japan Food Analysis Center.
In addition, condensed tannin was extracted with 200 ml (100 ml × 2 times) of methanolic hydrochloric acid solution (methanol 70%, concentrated hydrochloric acid 1%) at 80 ° C. for 30 minutes using 2 g of persimmon fruit powder composition, and the vanillin hydrochloric acid method was applied to the extract. The amount of condensed tannin was calculated using catechin as a standard substance (condensed tannin is included in dietary fiber for analysis).
（柿果実粉末組成物の分析結果）
上記の柿果実粉末組成物中の各成分を分析した結果を下記表１に示す。下記表１から明らかなように、本発明の柿果実粉末組成物は、従来の柿果実粉末組成物と比較して、食物繊維割合が高く、糖質が低いことを確認した。さらに、水溶性タンニン含有量が低いことをも確認した。
(Analysis results of strawberry fruit powder composition)
The results of analyzing each component in the above-mentioned strawberry fruit powder composition are shown in Table 1 below. As apparent from Table 1 below, it was confirmed that the strawberry fruit powder composition of the present invention had a high dietary fiber ratio and a low sugar content as compared with the conventional strawberry fruit powder composition. Furthermore, it was also confirmed that the water-soluble tannin content is low.
（糖尿病モデルマウスを用いた糖尿病治療効果の確認）
本発明の柿果実粉末組成物の糖尿病治療効果を確認するために、該組成物を糖尿病モデルマウスに摂取させ、さらに該マウスの血糖値を測定した。詳細は、以下の通りである。
(Confirmation of diabetes treatment effect using diabetes model mice)
In order to confirm the diabetes treatment effect of the strawberry fruit powder composition of the present invention, the composition was ingested by a diabetes model mouse, and the blood glucose level of the mouse was measured. Details are as follows.
（本発明の柿果実粉末組成物の摂取方法）
以下の条件により試験を行った。
実験動物：2型糖尿病モデルマウスNSY/Hos系統、オス、7週令（6週令を購入して、1週間予備飼育を行った）。
飼料：AIN-76改変高脂肪高カロリー食にセルロース又は本発明の柿果実粉末組成を添加した（参照：下記表２）。
実験群：体重及び血糖値に基づいて各群7匹ずつにわけた。
試験期間：10週間において、自由摂取を行った。
(Intake method of strawberry fruit powder composition of the present invention)
The test was conducted under the following conditions.
Experimental animals: Type 2 diabetes model mouse NSY / Hos strain, male, 7 weeks old (6 weeks old was purchased and pre-bred for 1 week).
Feed: AIN-76 modified high fat, high calorie diet was added with cellulose or persimmon fruit powder composition of the present invention (see: Table 2 below).
Experimental group: 7 animals were divided into each group based on body weight and blood glucose level.
Test period: Free intake was performed for 10 weeks.
（マウスの血糖値の測定方法）
血糖値の測定は、7時間絶食後、尾静脈からの血液を用いて簡単測糖Gチェッカー（三光純薬）により測定した。
(Method for measuring blood glucose level in mice)
The blood glucose level was measured with a simple glucose measuring G checker (Sanko Junyaku) using blood from the tail vein after fasting for 7 hours.
（マウスの血糖値の測定結果）
マウスの血糖値の測定結果を図１及び図２に示す。
柿果実粉末組成物又はセルロースの摂取期間中（試験中）において、本発明の柿果実粉末組成物摂取群の血糖値は低い傾向を示した（参照：図１）。
さらに、実験群の血糖値平均の比較により、本発明の柿果実粉末組成物摂取群で濃度依存的な差が見られた（参照：図２）。より詳しくは、セルロース摂取群では摂取期間中の血糖値が開始時と比較して有意に上昇していたが、本発明の柿果実粉末組成物3％摂取群及び5％摂取群は共に血糖値の上昇は認められなかった。柿果実粉末組成物又はセルロースの摂取期間中（試験中）において、柿果実粉末組成物3％摂取群（P<0.01）及び柿果実粉末組成物5％摂取群（P<0.001）ではセルロースのみの摂取群と比較して濃度依存的な血糖値の差が確認できた。
以上の結果により、本発明の柿果実粉末組成物は血糖値の上昇を抑える又は血糖値を下げる効果があり、糖尿病の予防、治療及び改善に効果がある。
(Measurement result of blood glucose level in mice)
The measurement results of the blood glucose level of the mouse are shown in FIGS.
During the ingestion period (under test) of the persimmon fruit powder composition or cellulose, the blood sugar level of the persimmon fruit powder composition intake group of the present invention tended to be low (see: FIG. 1).
Furthermore, by comparing the blood glucose level averages of the experimental group, a concentration-dependent difference was observed in the group ingesting the strawberry fruit powder composition of the present invention (see: FIG. 2). More specifically, in the cellulose ingestion group, the blood glucose level during the ingestion period was significantly higher than that at the start, but both the 3% ingestion group and the 5% ingestion group of the persimmon fruit powder composition of the present invention No increase was observed. During the intake period of the strawberry fruit powder composition or cellulose (during the test), only the cellulose was observed in the 3% intake group of the strawberry fruit powder composition (P <0.01) and the 5% intake group of the strawberry fruit powder composition (P <0.001). Compared with the ingested group, a concentration-dependent difference in blood glucose level was confirmed.
Based on the above results, the strawberry fruit powder composition of the present invention has an effect of suppressing an increase in blood sugar level or lowering a blood sugar level, and is effective in preventing, treating and improving diabetes.
（ヒトにおける糖尿病治療効果の確認）
ヒトでの試験を行うためにモニターを募集し、試験の内容を十分に理解し、了承の得られた健常者において、試験サンプル（参照：表３）を摂取してもらい、ヘモグロビンA1c（HbA1c）を測定した。詳細は、以下の通りである。
(Confirmation of therapeutic effects of diabetes in humans)
In order to conduct tests in humans, recruits monitors, fully understands the contents of the tests, and receives healthy test samples (see: Table 3) for healthy individuals who have obtained approval. Hemoglobin A1c (HbA1c) Was measured. Details are as follows.
（本発明の柿果実粉末組成物の摂取方法）
以下の条件により試験を行った。
健常人40名（25-51歳、男28名、女12名）に対する二重盲検-群間比較試験
試験サンプル：1本23ｇのクッキー（参照：表３）
試験群：
プラセボ群（男10名、女4名）本発明の柿果実粉末組成物を含有しないクッキーを食 前に1本摂取（1日3本、柿果実粉末組成物として0g/日）
低用量群（男9名、女4名）本発明の柿果実粉末組成物3g含有するクッキーを食前に1 本摂取（1日3本、柿果実粉末組成物として9g/日）
高用量群（男9名、女4名）本発明の柿果実粉末組成物5g含有するクッキーを食前に1 本摂取（1日3本、柿果実粉末組成物として15g/日）
試験期間：12週間
(Intake method of strawberry fruit powder composition of the present invention)
The test was conducted under the following conditions.
Double-blind-group comparison test for 40 healthy people (25-51 years old, 28 males, 12 females) Test sample: 1 23g cookie (Ref: Table 3)
Test group:
Placebo group (10 males, 4 females) Take 1 cookie before meals containing no strawberry fruit powder composition of the present invention (3 bottles per day, 0 g / day as strawberry fruit powder composition)
Low-dose group (9 males, 4 females) Ingest 1 cookie containing 3 g of persimmon fruit powder composition of the present invention before meal (3 per day, 9 g / day as persimmon fruit powder composition)
High-dose group (9 males, 4 females) Ingest 1 cookie containing 5 g of strawberry fruit powder composition of the present invention before meals (3 per day, 15 g / day as strawberry fruit powder composition)
Exam duration: 12 weeks
（HbA1cの測定方法）
HbA1cの測定は、早稲田メディカルクリニックに依頼して行った。
(Measurement method of HbA1c)
The measurement of HbA1c was performed at Waseda Medical Clinic.
（ヒトでのHbA1cの測定結果）
ヒトでのHbA1cの測定結果を図３に示す。
試験開始6週間に関し、いずれの群のHbA1c測定値は、試験開始前のHbA1c測定値と差が見られなかった。
しかし、試験開始12週間に関し、高用量摂取群のHbA1c測定値は、試験開始前HbA1cの測定値と比較して、有意な低下が確認された。HbA1cは最近1−2か月の血糖値の指標であることを考慮すると、本発明の柿果実粉末組成物はヒトの血糖値の上昇を抑える又は血糖値を下げる効果があり、糖尿病の予防、治療及び改善に効果がある。
(Measurement result of HbA1c in human)
The measurement results of human HbA1c are shown in FIG.
Regarding the 6 weeks after the start of the test, the HbA1c measurement values of any group did not differ from the HbA1c measurement values before the start of the test.
However, for the 12 weeks after the start of the study, the HbA1c measured value in the high-dose intake group was confirmed to be significantly lower than the measured value of HbA1c before the start of the study. Considering that HbA1c is an indicator of blood sugar levels in the last 1-2 months, the strawberry fruit powder composition of the present invention has the effect of suppressing or lowering blood sugar levels in humans, preventing diabetes, Effective for treatment and improvement.
（総論）
本発明の柿果実粉末組成物は、上記実施例１〜３により、従来の柿果実粉末組成物とは組成が明らかに異なり、さらに血糖値の上昇を抑える又は血糖値を下げる効果があり、糖尿病の予防、治療及び改善に効果がある。
加えて、本発明者らは、これまでの研究により、変異原性試験、動物を用いた安全性試験により、柿由来の成分の安全性を確認している。
以上により、本発明の柿果実粉末組成物を含む治療剤又は機能性食品は、安全性が十分に確認されている優れた血糖値低下効果を有する。
(General)
The strawberry fruit powder composition of the present invention is clearly different in composition from the conventional strawberry fruit powder composition according to Examples 1 to 3, and has an effect of suppressing an increase in blood sugar level or lowering a blood sugar level. Effective in prevention, treatment and improvement.
In addition, the present inventors have confirmed the safety of components derived from sputum by mutagenicity tests and safety tests using animals based on previous studies.
From the above, the therapeutic agent or functional food containing the strawberry fruit powder composition of the present invention has an excellent blood glucose level lowering effect whose safety is sufficiently confirmed.
本発明によれば、新規な血糖値低下効果を有する柿由来の組成物を提供することができる。 According to the present invention, it is possible to provide a sputum-derived composition having a novel blood sugar level lowering effect.
Claims (9)
（１）食物繊維が80.0〜93.0重量%であり、ここで、該食物繊維中の縮合型タンニンが5.0〜40.0重量％である；
（２）水分が1.0〜13.0重量%である；
（３）タンパク質が2.0〜6.0重量%である；
（４）脂質が0.1〜3.0重量％である；
（５）灰分が0.1〜3.0重量％である；
（６）糖質が1.0〜15.0重量％である。 The ratio of the said composition is the following, The composition of any one of Claims 1-4:
(1) dietary fiber is 80.0-93.0 wt%, where condensed tannin in the dietary fiber is 5.0-40.0 wt%;
(2) Moisture is 1.0-13.0% by weight;
(3) The protein is 2.0-6.0% by weight;
(4) The lipid is 0.1 to 3.0% by weight;
(5) Ash content is 0.1 to 3.0% by weight;
(6) Carbohydrate is 1.0 to 15.0% by weight.
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| WO2015125177A1 (en) * | 2014-02-21 | 2015-08-27 | 公立大学法人福井県立大学 | Muscle glucose uptake enhancer, hyperglycemia-improving agent, and preventive or therapeutic agent for diabetes and/or diabetic complications |
| JP2015182997A (en) * | 2014-03-26 | 2015-10-22 | 公益財団法人東洋食品研究所 | Persimmon fermentation composition and persimmon fruit treating method |
| KR102024541B1 (en) * | 2019-03-06 | 2019-09-24 | 농업회사법인 현대축산 주식회사 | Production method of high weight egg using feedstuff comprising persimmon for laying hens and eggs producted form the hens being fed with this feedstuff |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2015125177A1 (en) * | 2014-02-21 | 2015-08-27 | 公立大学法人福井県立大学 | Muscle glucose uptake enhancer, hyperglycemia-improving agent, and preventive or therapeutic agent for diabetes and/or diabetic complications |
| JP2015182997A (en) * | 2014-03-26 | 2015-10-22 | 公益財団法人東洋食品研究所 | Persimmon fermentation composition and persimmon fruit treating method |
| KR102024541B1 (en) * | 2019-03-06 | 2019-09-24 | 농업회사법인 현대축산 주식회사 | Production method of high weight egg using feedstuff comprising persimmon for laying hens and eggs producted form the hens being fed with this feedstuff |
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