JP2013032383A - Hair-dyeing agent composition - Google Patents
Hair-dyeing agent composition Download PDFInfo
- Publication number
- JP2013032383A JP2013032383A JP2012237659A JP2012237659A JP2013032383A JP 2013032383 A JP2013032383 A JP 2013032383A JP 2012237659 A JP2012237659 A JP 2012237659A JP 2012237659 A JP2012237659 A JP 2012237659A JP 2013032383 A JP2013032383 A JP 2013032383A
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- JP
- Japan
- Prior art keywords
- agent
- hair
- derivatives
- acid
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003795 chemical substances by application Substances 0.000 claims abstract description 121
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 4
- 125000005907 alkyl ester group Chemical group 0.000 description 4
- 238000012790 confirmation Methods 0.000 description 4
- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 description 4
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- 235000008390 olive oil Nutrition 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229960000969 phenyl salicylate Drugs 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 235000011118 potassium hydroxide Nutrition 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 229940058287 salicylic acid derivative anticestodals Drugs 0.000 description 1
- 150000003872 salicylic acid derivatives Chemical class 0.000 description 1
- 150000003902 salicylic acid esters Chemical class 0.000 description 1
- 239000001026 semi permanent hair color Substances 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 239000001027 temporary hair color Substances 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、非酸化型の二剤式染毛剤組成物であって、優れた染毛効果及び白髪かくし効果を奏する染毛剤組成物に関する。 The present invention relates to a non-oxidizing two-component hair dye composition, which relates to a hair dye composition that exhibits an excellent hair dyeing effect and a gray hair combing effect.
染毛剤は、性能の面から、（１）一時染毛料、（２）半永久染毛料、（３）永久染毛剤に大きく分類される。 Hair dyes are broadly classified into (1) temporary hair dyes, (2) semi-permanent hair dyes, and (3) permanent hair dyes in terms of performance.
このうち永久染毛剤においてこれまで一般に広く利用されているものは、パラフェニレンジアミンを主体とした酸化染料及びアルカリ剤を配合した第1剤と、酸化剤、主に過酸
化水素水を配合した第2剤とを混合して使用する酸化型の染毛剤である。しかしながら、
酸化型の染毛剤はアルカリ剤及び過酸化水素水の作用により、毛髪にダメージを与えることがある。また一部の酸化染料により強いアレルギー反応が示されることもある。
Among these, those that have been widely used so far in permanent hair dyes were formulated with a first agent containing an oxidation dye and an alkali agent mainly composed of paraphenylenediamine, and an oxidizing agent, mainly hydrogen peroxide. It is an oxidation type hair dye used by mixing with the second agent. However,
Oxidizing hair dyes may damage hair due to the action of alkaline agents and hydrogen peroxide. Some oxidative dyes may show a strong allergic reaction.
一方、多価フェノール類と金属塩との反応を利用して染毛する、非酸化型の染毛剤も知られている（特許文献１〜７参照）。しかし、これまでの非酸化型の染毛剤において、染毛効果及び白髪かくし効果は十分に満足し得るものではなかった。
本発明は、優れた染毛効果及び白髪かくし効果を有し、かつその持続性が高く、皮膚障害の少ない染毛剤を提供することを主な目的とする。 The main object of the present invention is to provide a hair dye that has an excellent hair dyeing effect and a gray hair combing effect, is highly durable, and has few skin disorders.
本発明者らは、上記目的を達成すべく鋭意研究をすすめた結果、特定の組成の染毛剤組成物が、染毛効果及び白髪かくし効果に優れ、更に皮膚障害も少ない利点を有することを見出し、更に鋭意検討を重ねて本発明を完成するに至った。 As a result of intensive studies to achieve the above object, the present inventors have found that the hair dye composition having a specific composition has the advantages of excellent hair dyeing effect and gray hair combing effect, and less skin damage. The present invention has been completed through repeated headings and further intensive studies.
即ち、本発明は、以下の染毛剤組成物に関する。 That is, the present invention relates to the following hair dye composition.
第１剤及び第２剤からなる二剤式染毛剤組成物であって、
第１剤が、
（ｉ）没食子酸及びその誘導体からなる群から選ばれる1以上、及び／又は、
（ii）サリチル酸及びその誘導体からなる群より選ばれる1以上
を含んでなり、
第２剤が、鉄塩を含んでなり、かつ、
第１剤及び第２剤のうち少なくとも一方が、尿素を含んでいる
組成物。
A two-component hair dye composition comprising a first agent and a second agent,
The first agent
(I) one or more selected from the group consisting of gallic acid and derivatives thereof, and / or
(Ii) comprising one or more selected from the group consisting of salicylic acid and derivatives thereof,
The second agent comprises an iron salt, and
A composition in which at least one of the first agent and the second agent contains urea.
以下、本発明についてより詳細に説明する。 Hereinafter, the present invention will be described in more detail.
本発明の染毛剤組成物は、第１剤及び第２剤からなる二剤式の染毛剤組成物であって、第１剤と第２剤を混合させることで染毛するものである。好ましくは、第1剤を塗布し一
定時間放置後、第2剤を第1剤と混ざり合うように塗布して染毛するものである。
The hair dye composition of the present invention is a two-component hair dye composition comprising a first agent and a second agent, and dyes hair by mixing the first agent and the second agent. . Preferably, the first agent is applied and allowed to stand for a certain period of time, and then the second agent is applied so as to be mixed with the first agent and dyed.
また、本明細書において、染毛剤とは、毛髪に色を付ける又は毛髪の色を変えるためのものであり、ヘアダイ、ヘアマニキュア、白髪染め剤などを含むものであり、染毛剤組成物とは、そのような用途に使用するための組成物を意図する。 Further, in the present specification, the hair dye is for coloring the hair or changing the color of the hair, and includes a hair dye, a hair manicure, a white hair dye, and the like. Contemplates a composition for use in such applications.
１．没食子酸又はその誘導体、並びに、サリチル酸又はその誘導体
本発明の第１剤は、（ｉ）没食子酸及びその誘導体からなる群から選ばれる1以上、及
び／又は、（ｉｉ）サリチル酸及びその誘導体からなる群より選ばれる1以上を含んでい
る。
1. Gallic acid or derivatives thereof, and salicylic acid or derivatives thereof The first agent of the present invention comprises (i) one or more selected from the group consisting of gallic acid and derivatives thereof, and / or (ii) salicylic acid and derivatives thereof. Contains one or more selected from the group.
第１剤は、（ｉ）没食子酸及びその誘導体からなる群から選ばれる1以上又は（ｉｉ）
サリチル酸及びその誘導体からなる群より選ばれる1以上のいずれかを含むものであって
もよく、（ｉ）及び（ｉｉ）の両者を含んでいるものであってもよい。
The first agent is (i) one or more selected from the group consisting of gallic acid and derivatives thereof, or (ii)
Any one or more selected from the group consisting of salicylic acid and derivatives thereof may be included, and both (i) and (ii) may be included.
（ｉ）没食子酸及びその誘導体、及び／又は、（ｉｉ）サリチル酸及びその誘導体は、鉄塩との反応により発色して、毛髪に色素を固定するために配合される。 (I) Gallic acid and its derivatives, and / or (ii) Salicylic acid and its derivatives are formulated to develop color by reaction with an iron salt and fix the pigment on the hair.
（ｉ）没食子酸又はその誘導体
没食子酸の誘導体としては、例えば、没食子酸のアルキルエステルが挙げられる。没食子酸のアルキルエステルとしては、例えば、炭素数１〜１０、好ましくは２〜５の直鎖状又は分岐状のアルキルエステルが挙げられる。例えば、没食子酸エチル、没食子酸プロピル、没食子酸イソアミルなどが含まれる。
(I) Gallic acid or derivatives thereof Examples of gallic acid derivatives include alkyl esters of gallic acid. Examples of alkyl esters of gallic acid include linear or branched alkyl esters having 1 to 10 carbon atoms, preferably 2 to 5 carbon atoms. For example, ethyl gallate, propyl gallate, isoamyl gallate and the like are included.
没食子酸又はその誘導体は、公知の方法に従って化学的に合成して得られるものでもよく、植物から単離して得られるものであってもよい。また植物から単離したものに化学的な合成を加えたものであってもよい。また、植物から得られる没食子酸又はその誘導体を含有するエキスをそのまま用いてもよい。例えば、マメ科植物タラ由来の没食子酸やウルシ科ヌルデに発生する五倍子由来の没食子酸又はそれらを含有するエキスなどを用いることができる。またそれらの没食子酸を化学的にエステル化して得られた誘導体を用いることもできる。 Gallic acid or a derivative thereof may be obtained by chemical synthesis according to a known method, or may be obtained by isolation from a plant. Moreover, what added the chemical synthesis | combination to what was isolated from the plant may be used. Moreover, you may use the extract containing the gallic acid obtained from a plant, or its derivative (s) as it is. For example, gallic acid derived from leguminous plant cod, gallic acid derived from pentaploid which occurs in urchinaceae, or extracts containing them can be used. In addition, derivatives obtained by chemically esterifying those gallic acids can also be used.
没食子酸又はその誘導体の配合量は、本発明の効果を奏する範囲内で適宜設定し得るが、第１剤全量に対し0.1〜10重量％程度、好ましくは0.2〜5重量％程度、より好ましくは0.5〜3重量％程度である。 The amount of gallic acid or a derivative thereof can be set as appropriate within the range where the effects of the present invention are exerted, but it is about 0.1 to 10% by weight, preferably about 0.2 to 5% by weight, more preferably, based on the total amount of the first agent. About 0.5 to 3% by weight.
この範囲であれば染毛性、使用性、製剤の安定性等の効果に優れる。 If it is this range, it is excellent in effects, such as hair dyeing property, usability, and stability of a formulation.
（２）サリチル酸又はその誘導体
サリチル酸の誘導体には、サリチル酸のエステルや塩が含まれる。サリチル酸の塩としては、サリチル酸のアルカリ金属塩が挙げられる。具体的にはサリチル酸ナトリウムが挙げられる。またサリチル酸のエステルとしては、炭素数１〜１０の直鎖状又は分岐状のアルキルエステルやフェニルエステルが挙げられる。具体的にはサリチル酸オクチル、サリチル酸フェニル、サリチル酸メチルなどが挙げられる。
(2) Salicylic acid or derivatives thereof Salicylic acid derivatives include esters and salts of salicylic acid. Examples of the salicylic acid salt include alkali metal salts of salicylic acid. Specific examples include sodium salicylate. Examples of salicylic acid esters include linear or branched alkyl esters and phenyl esters having 1 to 10 carbon atoms. Specific examples include octyl salicylate, phenyl salicylate, and methyl salicylate.
サリチル酸又はその誘導体は１種用いてもよく、２種以上を組み合わせて用いてもよい。
サリチル酸又はその誘導体の配合量には、所望の効果を奏することを目的として適宜設定し得るが、第１剤全量に対し0.1〜3重量％程度、好ましくは0.2〜2重量％程度である。
One type of salicylic acid or a derivative thereof may be used, or two or more types may be used in combination.
The amount of salicylic acid or a derivative thereof can be appropriately set for the purpose of achieving a desired effect, but is about 0.1 to 3% by weight, preferably about 0.2 to 2% by weight, based on the total amount of the first agent.
この範囲であれば、染毛性、使用性、製剤の安定性等の効果に優れる。 If it is this range, it is excellent in effects, such as hair dyeing property, usability, and stability of a formulation.
第１剤には、没食子酸及びその誘導体並びにサリチル酸及びその誘導体以外に、他の多価フェノール又はその誘導体を１種又は２種以上用いてもよい。他の多価フェノールとしては、ヘマテイン、タンニン酸、ピロガロール、ヘマトキシリン、カテコールなどが挙げられる。特にヘマテイン、タンニン酸等が挙げられる。それらの配合量は、本発明の効果を奏する範囲内で適宜設定することができるが、通常、第１剤全量に対し、0.01〜2重量
％程度、好ましくは0.1〜1重量％程度である。
As the first agent, in addition to gallic acid and its derivatives and salicylic acid and its derivatives, one or more other polyphenols or their derivatives may be used. Other polyphenols include hematein, tannic acid, pyrogallol, hematoxylin, catechol and the like. In particular, hematein, tannic acid and the like can be mentioned. These blending amounts can be appropriately set within the range where the effects of the present invention are exhibited, but are usually about 0.01 to 2% by weight, preferably about 0.1 to 1% by weight, based on the total amount of the first agent.
第１剤のpHは、6.5〜9.0、好ましくは7.5〜8.5程度である。この範囲であると十分な染毛効果が得られ、皮膚刺激の恐れも少ない。 The pH of the first agent is 6.5 to 9.0, preferably about 7.5 to 8.5. Within this range, a sufficient hair dyeing effect can be obtained and there is little risk of skin irritation.
２．鉄塩
本発明は、第２剤に、鉄塩を含んでいる。
2. Iron salt In the present invention, the second agent contains an iron salt.
鉄塩は、没食子酸、サリチル酸及びそれらの誘導体との反応により発色して、毛髪に色素を固定するために配合される。 The iron salt is formulated to develop a color by reaction with gallic acid, salicylic acid and derivatives thereof and fix the pigment to the hair.
鉄塩としては、例えば、硫酸第一鉄、塩化第一鉄、酢酸第一鉄、リン酸第一鉄、シュウ酸第一鉄などを挙げることができる。 Examples of the iron salt include ferrous sulfate, ferrous chloride, ferrous acetate, ferrous phosphate, and ferrous oxalate.
鉄塩の量は、本発明の効果を奏する範囲内で適宜設定し得るが、通常第２剤全量に基づき、0.5〜10重量％程度、好ましくは1〜6重量％程度である。 The amount of the iron salt can be appropriately set within the range where the effects of the present invention are exhibited, but is usually about 0.5 to 10% by weight, preferably about 1 to 6% by weight, based on the total amount of the second agent.
第2剤のpHは、2.0〜4.0、好ましくは2.5〜3.5程度である。この範囲であると十分な染
毛効果が得られ、製品の安定性を損ねる恐れも少ない。
The pH of the second agent is about 2.0 to 4.0, preferably about 2.5 to 3.5. Within this range, a sufficient hair dyeing effect can be obtained and there is little risk of impairing the stability of the product.
３．尿素
本発明の組成物は、第１剤と第２剤のいずれか一方又は両方に尿素を含んでいる。尿素は、染毛効果や白髪かくし効果を高めるために配合される。
3. Urea The composition of the present invention contains urea in one or both of the first agent and the second agent. Urea is blended to enhance the hair dyeing effect and the gray hair combing effect.
尿素の配合量は、本発明の効果を奏する範囲内で適宜設定し得るが、第１剤のみに配合する場合、第１剤全体に対し、通常1〜20重量％程度、好ましくは4〜10重量％程度である。第２剤のみに配合する場合、第２剤全体に対し、通常1〜20重量％程度、好ましくは4〜10重量％程度である。また第１剤と第２剤の両者に配合する場合、それらの合計で組成物全体に対し、通常1〜20重量％程度、好ましくは4〜10重量％程度である。 The blending amount of urea can be appropriately set within the range where the effects of the present invention are exerted. However, when blended only in the first agent, it is usually about 1 to 20% by weight, preferably 4 to 10%, based on the entire first agent. It is about wt%. When it mix | blends only with 2nd agent, it is about 1-20 weight% normally with respect to the whole 2nd agent, Preferably it is about 4-10 weight%. Moreover, when mix | blending with both a 1st agent and a 2nd agent, it is about 1-20 weight% normally with respect to the whole composition in total, Preferably it is about 4-10 weight%.
尿素は特に第１剤に含有されていることが好ましい。第１剤に尿素を含有することで、染毛効果及び白髪かくし効果がより高くなる。 Urea is particularly preferably contained in the first agent. By containing urea in the first agent, the hair dyeing effect and the gray hair combing effect become higher.
４.他の成分
本発明の第１剤及び／又は第２剤には、所望に応じ、本発明の効果を阻害しない範囲で、公知の染毛剤組成物に用いられている他の成分を適宜添加することができる。
4. Other components The first agent and / or the second agent of the present invention may contain other components used in known hair dye compositions as long as they do not inhibit the effects of the present invention. It can be added as appropriate.
他の成分としては、例えば、基剤、界面活性剤、酸化防止剤、ｐＨ調整剤、湿潤剤、溶剤等を挙げることができる。 Examples of other components include a base, a surfactant, an antioxidant, a pH adjuster, a wetting agent, and a solvent.
基剤としては、高級アルコール類、炭化水素、脂肪酸エステル、植物油、脂肪酸などを挙げることができる。 Examples of the base include higher alcohols, hydrocarbons, fatty acid esters, vegetable oils, fatty acids and the like.
高級アルコール類としては、例えば、セタノール、ステアリルアルコール、オレイルアルコール、ベヘニルアルコール、ヘキシルドデカノール、オクチルドデカノール等を挙げることができる。
炭化水素としては、パラフィン、流動パラフィン、ワセリン等を挙げることができる。
脂肪酸エステルとしては、ミリスチン酸イソプロピル、パルミチン酸イソプロピル、パルミチン酸セチル、ステアリン酸ステアリル等を挙げることができる。
植物油としては、オリーブ油、パーシック油、アルモンド油、アボガド油等を挙げることができる。
脂肪酸としては、ミリスチン酸、パルミチン酸、ステアリン酸、オレイン酸等を挙げることができる。
界面活性剤としては、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリエチレングリコール脂肪酸エステル、ポリオキシエチレンアルキルエーテルリン酸及びその塩、アルキルグルコシド、Ｎ−アシルアミノ酸塩、アルキルエーテルカルボン酸塩、アルキル硫酸塩、ポリオキシエチレンアルキルエーテル硫酸塩、スルホン酸塩、アルキルアンモニウム塩、アルキルアミドプロピルベタイン等を挙げることができる。
Examples of the higher alcohols include cetanol, stearyl alcohol, oleyl alcohol, behenyl alcohol, hexyl decanol, and octyl decanol.
Examples of the hydrocarbon include paraffin, liquid paraffin, and petroleum jelly.
Examples of fatty acid esters include isopropyl myristate, isopropyl palmitate, cetyl palmitate, stearyl stearate, and the like.
Examples of vegetable oils include olive oil, persic oil, almond oil, and avocado oil.
Examples of fatty acids include myristic acid, palmitic acid, stearic acid, oleic acid and the like.
Surfactants include polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, glycerin fatty acid ester, polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether phosphoric acid and salts thereof, alkyl glucoside, N -Acyl amino acid salts, alkyl ether carboxylates, alkyl sulfates, polyoxyethylene alkyl ether sulfates, sulfonates, alkyl ammonium salts, alkylamidopropyl betaines and the like.
酸化防止剤としては、アスコルビン酸及びその誘導体、亜硫酸ナトリウム等を挙げることができる。 Examples of the antioxidant include ascorbic acid and derivatives thereof, sodium sulfite and the like.
ｐＨ調整剤としては、クエン酸、リン酸、アンモニア、炭酸水素アンモニウム、炭酸アンモニウム、水酸化カリウム、水酸化ナトリウム、モノエタノールアミン、イソプロパノールアミン、リン酸アンモニウム、リン酸一水素二アンモニウム、クエン酸ナトリウム、クエン酸アンモニウム、リン酸カリウム、リン酸ナトリウム等を用いることができる。 pH adjusters include citric acid, phosphoric acid, ammonia, ammonium bicarbonate, ammonium carbonate, potassium hydroxide, sodium hydroxide, monoethanolamine, isopropanolamine, ammonium phosphate, diammonium phosphate monobasic, sodium citrate , Ammonium citrate, potassium phosphate, sodium phosphate and the like can be used.
湿潤剤としては、1,3−ブチレングリコール、プロピレングリコール、グリセリン、ソ
ルビトール、ピロリドンカルボン酸ナトリウム、アミノ酸、植物油等を挙げることができる。
Examples of the wetting agent include 1,3-butylene glycol, propylene glycol, glycerin, sorbitol, sodium pyrrolidonecarboxylate, amino acid, vegetable oil and the like.
増粘剤としては、例えば、キサンタンガム、ポリエチレングリコール、ヒドロキシエチルセルロース等を挙げることができる。 Examples of the thickener include xanthan gum, polyethylene glycol, hydroxyethyl cellulose and the like.
溶剤としては、精製水を挙げることができる。また、没食子酸の誘導体を溶かすことなどを目的として、1,3-ブチレングリコールやプロピレングリコール、グリセリンを用いることもできる。 An example of the solvent is purified water. Further, 1,3-butylene glycol, propylene glycol, and glycerin can be used for the purpose of dissolving a derivative of gallic acid.
これらは１種用いてもよく２種以上用いてもよい。また、それらの配合量は、本発明の効果を奏する範囲内で適宜設定することができる。 These may be used alone or in combination of two or more. Moreover, those compounding quantities can be suitably set within the range where the effects of the present invention are exhibited.
５．二剤式染毛剤組成物
本発明の染毛剤組成物は、第１剤及び第２剤からなる二剤式の染毛剤組成物であって、第１剤と第２剤を混合させることで染毛する。
5. Two-component hair dye composition The hair dye composition of the present invention is a two-component hair dye composition comprising a first agent and a second agent, and the first agent and the second agent are mixed together. I dye my hair.
二剤式であることにより、色素を構成する没食子酸又はその誘導体或いはサリチル酸又はその誘導体や、鉄塩が毛髪内部に入りやすく、毛髪内部でそれらの錯体が初めて形成されるため、染毛効果が高く、かつ、染毛後それらの色素が抜け落ちにくいという利点を有する。 Since it is a two-part type, gallic acid or its derivative or salicylic acid or its derivative constituting the pigment or iron salt easily enters the inside of the hair, and their complex is formed for the first time inside the hair. High and has the advantage that these pigments are difficult to come off after hair dyeing.
第１剤と第２剤の形態は、適宜設定し得るが、塗布のしやすさなどの点から、クリーム状であることが好ましい。 The forms of the first agent and the second agent can be set as appropriate, but are preferably creamy in terms of ease of application.
第1剤及び第2剤の調製方法も、特に限定されず、常法に従って行うことができるが、例えば、第１剤の場合、次のように調製することができる：
界面活性剤等の油相成分と、没食子酸又はその誘導体或いはサリチル酸又はその誘導体等の水相成分とを、別々に量り取り、それぞれ十分に加熱溶解させた後、油相成分によくかきまぜながら水相成分を添加して乳化する。その後冷却し、pH調整剤及び水に溶かした尿素を添加して仕上げることができる。また実施例に記載の方法に従って調製することもできる。
The method for preparing the first agent and the second agent is not particularly limited, and can be performed according to a conventional method. For example, in the case of the first agent, it can be prepared as follows:
Oil phase components such as surfactants and water phase components such as gallic acid or derivatives thereof or salicylic acid or derivatives thereof are weighed separately, dissolved sufficiently with heating, and then mixed with the oil phase components and mixed with water. Add phase ingredients and emulsify. Thereafter, it can be cooled and finished by adding a pH adjuster and urea dissolved in water. Moreover, it can also prepare according to the method as described in an Example.
また、第2剤の場合、次のように調製することができる：
界面活性剤の油相成分と、鉄塩、pH調整剤等の水相成分とを別々に量り取り、それぞれ十分に加熱溶解させた後、油相成分をよくかきまぜながら水相成分を添加して乳化する。その後冷却し、水に溶かした尿素を添加して仕上げることができる。また、実施例に記載の方法に従って調製することもできる。
In the case of the second agent, it can be prepared as follows:
Weigh out the oil phase component of the surfactant and the water phase component such as iron salt and pH adjuster separately, dissolve them sufficiently with heating, and then add the water phase component while thoroughly stirring the oil phase component. Emulsify. It can then be cooled and finished by adding urea dissolved in water. Moreover, it can also prepare according to the method as described in an Example.
第１剤の実施態様の一例としては、
第１剤の全量に対して、
（ｉ）没食子酸及びその誘導体からなる群から選ばれる１以上を、第１剤全量に対し0.1〜10重量％程度、好ましくは0.2〜5重量％程度、より好ましくは0.5〜3重量％程度含有
し、及び／又は
（ｉｉ）サリチル酸及びその誘導体からなる群より選ばれる1以上を、第１剤全量に対
し0.1〜3重量％程度、好ましくは0.2〜2重量％程度含有し、かつ、
（ｉｉｉ）尿素を1〜20重量％程度、好ましくは4〜10重量％程度
含有してなるものである。
As an example of the embodiment of the first agent,
For the total amount of the first agent,
(I) One or more selected from the group consisting of gallic acid and derivatives thereof is contained in an amount of about 0.1 to 10% by weight, preferably about 0.2 to 5% by weight, more preferably about 0.5 to 3% by weight, based on the total amount of the first agent. And / or (ii) one or more selected from the group consisting of salicylic acid and derivatives thereof, about 0.1 to 3% by weight, preferably about 0.2 to 2% by weight, based on the total amount of the first agent, and
(Iii) It contains about 1 to 20% by weight of urea, preferably about 4 to 10% by weight.
第２剤の実施態様の一例としては、
第２剤全量に対し、
鉄塩を0.5〜10重量％程度、好ましくは1〜6重量％程度含有し、更に第１剤が尿素を含
有していない場合、尿素を1〜20重量％程度、好ましくは4〜10重量％程度
含有してなるものである。
As an example of the embodiment of the second agent,
For the total amount of the second agent
When iron salt is contained in an amount of about 0.5 to 10% by weight, preferably about 1 to 6% by weight, and the first agent does not contain urea, urea is about 1 to 20% by weight, preferably 4 to 10% by weight. To the extent that it is contained.
また、二剤式染毛組成物の実施態様の一例としては、
第１剤及び第２剤からなる二剤式染毛剤組成物であって、
第１剤が、
（ｉ）没食子酸及びその誘導体からなる群から選ばれる１以上を、第１剤全量に対し0.1〜10重量％程度、好ましくは0.2〜5重量％程度、より好ましくは0.5〜3重量％程度含有
し、及び／又は
（ｉｉ）サリチル酸及びその誘導体からなる群より選ばれる1以上を、第１剤全量に対
し0.1〜3重量％程度、好ましくは0.2〜2重量％程度含有してなり、
第２剤が、鉄塩を第２剤全量に対し、0.5〜10重量％程度、好ましくは1〜6重量％程度
含有してなり、かつ、
第１剤と第２剤の少なくとも１一方が、尿素を、第１剤及び／又は第２剤全量に対して1〜20重量％程度、好ましくは4〜10重量％程度含有してなる組成物
が挙げられる。
Moreover, as an example of the embodiment of the two-component hair dye composition,
A two-component hair dye composition comprising a first agent and a second agent,
The first agent
(I) One or more selected from the group consisting of gallic acid and derivatives thereof is contained in an amount of about 0.1 to 10% by weight, preferably about 0.2 to 5% by weight, more preferably about 0.5 to 3% by weight, based on the total amount of the first agent. And / or (ii) one or more selected from the group consisting of salicylic acid and its derivatives, about 0.1 to 3% by weight, preferably about 0.2 to 2% by weight, based on the total amount of the first agent,
The second agent contains about 0.5 to 10% by weight, preferably about 1 to 6% by weight of iron salt with respect to the total amount of the second agent, and
A composition in which at least one of the first agent and the second agent contains urea in an amount of about 1 to 20% by weight, preferably about 4 to 10% by weight, based on the total amount of the first agent and / or the second agent. Is mentioned.
第１剤と第２剤の割合は、本発明の効果を奏する範囲内で適宜設定し得るが、通常、重量比で、第1剤：第２剤＝1：0.5〜1：2程度、好ましくは約１：１程度である。 The ratio of the first agent and the second agent can be appropriately set within the range where the effects of the present invention are exerted, but usually the first agent: second agent = 1: 0.5 to 1: 2, preferably by weight ratio. Is about 1: 1.
本発明の二剤式染毛剤組成物は、第１剤と第２剤を混合して使用する。例えば、第１剤を先に毛髪に塗布し、次いで、第２剤を塗布して、混合させることにより染色して使用することができる。 The two-component hair dye composition of the present invention is used by mixing the first agent and the second agent. For example, the first agent can be applied to the hair first, and then the second agent can be applied and mixed to be mixed and used.
具体的には、第1剤を先に塗布して一定時間放置後、第2剤を塗布し一定時間放置後、洗い流して使用する。 Specifically, the first agent is applied first and allowed to stand for a certain period of time, then the second agent is applied and allowed to stand for a certain period of time, and then rinsed and used.
毛髪に対する塗布量は、所望に応じて適宜設定し得るが、長さ30cm程度の全頭で、第1
剤を50〜90g程度、第２剤が50〜90g程度、好ましくは、第1剤を70g程度、第２剤が70g程
度である。
The amount applied to the hair can be appropriately set as desired, but the first head is about 30 cm in length.
About 50 to 90 g of the agent, about 50 to 90 g of the second agent, preferably about 70 g of the first agent and about 70 g of the second agent.
尚、本発明の染毛剤組成物には、染毛及び染毛剤組成物に関する公知の技術を必要に応じて付加し得るものである。 In addition, the well-known technique regarding hair dye and a hair dye composition can be added to the hair dye composition of this invention as needed.
本発明の染毛剤組成物によると、1回の染毛施術であっても持続性の高い染毛効果及び
白髪かくし効果を得ることができる。
According to the hair dye composition of the present invention, a long-lasting hair dyeing effect and a gray hair combing effect can be obtained even with a single hair dyeing treatment.
また、本発明の染毛剤組成物は、アレルギー反応、換言すると皮膚障害が少なく、ジアミン系酸化染料によるかぶれが生じる使用者にも適用できる。 In addition, the hair dye composition of the present invention is applicable to a user who is less susceptible to allergic reactions, in other words, skin damage, and rashes caused by diamine-based oxidation dyes.
以下、本発明をより詳細に説明するために実施例を用いて説明するが、本発明はこれら実施例に制限されるものではない。 Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to these examples.
尚、実施例及び比較例では、以下の材料を用いた。
没食子酸：マメ科植物タラ由来没食子酸（岩手ケミカル株式会社製）
没食子酸プロピル：マメ科植物タラ由来没食子酸のエステル（岩手ケミカル株式会社）
サリチル酸ナトリウム：（株式会社ＡＰＩコーポレーション製）
Ｌ-アスコルビン酸：Ｌ(+)−アスコルビン酸 （和光純薬工業株式会社製）
炭酸水素アンモニウム：炭酸水素アンモニウム （和光純薬工業株式会社製）
強アンモニア水：アンモニア水（濃度28〜30％）（和光純薬工業株式会社製）
水酸化カリウム：水酸化カリウムペレット（和光純薬工業株式会社製）
硫酸第一鉄：硫酸鉄（II）七水和物（和光純薬工業株式会社製）
塩化第一鉄：塩化鉄（II）四水和物（和光純薬工業株式会社製）
尿素：尿素（和光純薬工業株式会社製）
プロピレングリコール：プロピレングリコール（旭硝子株式会社製）
ヘマテイン：ヘマテインR（丸善製薬株式会社製）
セタノール：セタノールSX（高級アルコール工業株式会社製）
ピロガロール：ピロガロールN（大日本製薬株式会社製）
ポリオキシエチレン(20)セチルエーテル：NIKKOL BC-20（日本サーファクタント工業株式会社製）
In the examples and comparative examples, the following materials were used.
Gallic acid: Gallic acid derived from legume cod (Iwate Chemical Co., Ltd.)
Propyl gallate: ester of gallic acid from legume cod (Iwate Chemical Co., Ltd.)
Sodium salicylate: (manufactured by API Corporation)
L-ascorbic acid: L (+)-ascorbic acid (manufactured by Wako Pure Chemical Industries, Ltd.)
Ammonium bicarbonate: Ammonium bicarbonate (Wako Pure Chemical Industries, Ltd.)
Strong ammonia water: Ammonia water (concentration 28-30%) (Wako Pure Chemical Industries, Ltd.)
Potassium hydroxide: Potassium hydroxide pellets (Wako Pure Chemical Industries, Ltd.)
Ferrous sulfate: Iron (II) sulfate heptahydrate (Wako Pure Chemical Industries, Ltd.)
Ferrous chloride: Iron (II) chloride tetrahydrate (manufactured by Wako Pure Chemical Industries, Ltd.)
Urea: Urea (Wako Pure Chemical Industries, Ltd.)
Propylene glycol: Propylene glycol (Asahi Glass Co., Ltd.)
Hematein: Hematein R (Maruzen Pharmaceutical Co., Ltd.)
Cetanol: Cetanol SX (manufactured by Higher Alcohol Industry Co., Ltd.)
Pyrogallol: Pyrogallol N (Dainippon Pharmaceutical Co., Ltd.)
Polyoxyethylene (20) cetyl ether: NIKKOL BC-20 (manufactured by Nippon Surfactant Co., Ltd.)
試験例１（染毛効果及び白髪かくし効果）
表３〜５に示す第1剤、第2剤を以下のように調製し、その染毛効果及び白髪かくし効果を評価した。
Test example 1 (hair dyeing effect and gray hair combing effect)
The 1st agent and 2nd agent which are shown in Tables 3-5 were prepared as follows, and the hair dyeing effect and the gray hair combing effect were evaluated.
第１剤の調製方法
実施例1〜18及び比較例1〜3、5〜7及び9においては、プロピレングリコールと、表３〜
５に示す没食子酸及び／又は没食子酸プロピルを混ぜた中に、50℃の精製水を加え、更にサリチル酸ナトリウム及び／又はヘマテインを加えた後、L-アスコルビン酸を加えて溶かした。得られた溶液を常温まで攪拌冷却した後、ｐH調整剤として炭酸水素アンモニウム
及び水酸化カリウムを加えた。実施例１〜16及び18においては、更に尿素を加えた。得られた溶液を十分に攪拌して仕上がりとした。
Preparation Examples of First Agent In Examples 1 to 18 and Comparative Examples 1 to 3, 5 to 7 and 9, propylene glycol and Table 3
Purified water at 50 ° C. was added to the mixture of gallic acid and / or propyl gallate shown in 5, and then sodium salicylate and / or hematein was added, and then L-ascorbic acid was added and dissolved. The resulting solution was stirred and cooled to room temperature, and then ammonium hydrogen carbonate and potassium hydroxide were added as pH adjusters. In Examples 1-16 and 18, more urea was added. The resulting solution was sufficiently stirred to finish.
比較例4、8及び10においては、プロピレングリコールに、50℃の精製水を加え、更に、L-アスコルビン酸を加えて溶かした。次いで、得られた溶液を常温まで攪拌冷却した後、ｐH調整剤として炭酸水素アンモニウム及び水酸化カリウムを加えた。比較例10において
は更に尿素を加えた。得られた溶液を十分に攪拌して仕上がりとした。
In Comparative Examples 4, 8, and 10, purified water at 50 ° C. was added to propylene glycol, and further L-ascorbic acid was added and dissolved. Subsequently, after stirring and cooling the obtained solution to normal temperature, ammonium hydrogen carbonate and potassium hydroxide were added as a pH adjuster. In Comparative Example 10, urea was further added. The resulting solution was sufficiently stirred to finish.
実施例及び比較例の組成成分の種類と割合は表３〜５に示すとおりである。pH調整剤である炭酸水素アンモニウム及び水酸化カリウムの量は、得られた溶液のpHが7.5になるよ
うに調整した。
The types and ratios of the composition components in Examples and Comparative Examples are as shown in Tables 3-5. The amounts of ammonium bicarbonate and potassium hydroxide as pH adjusting agents were adjusted so that the pH of the obtained solution was 7.5.
第２剤の調製方法
常温の精製水に、硫酸第一鉄又は塩化第一鉄を加え、更に、Ｌ-アスコルビン酸を加え
た。実施例17及び18においては、更に尿素を加えた。得られた溶液を、攪拌溶解して仕上げた。得られた溶液のpHは3程度であった。
Preparation method of second agent Ferrous sulfate or ferrous chloride was added to purified water at room temperature, and L-ascorbic acid was further added. In Examples 17 and 18, more urea was added. The resulting solution was stirred and dissolved to finish. The pH of the obtained solution was about 3.
染毛効果及び白髪かくし効果の確認試験は以下のようにして行った。 The confirmation test of the hair dyeing effect and the gray hair combing effect was performed as follows.
染毛効果
シャンプー及びリンス処理した毛束1g（白髪率100％）に第1剤を2g塗布し、30℃、相対湿度65％下で15分間放置後、第2剤を2g塗布し、再度30℃、相対湿度65％下で15分間放置
した。その後、シャンプー及びリンス処理し、ドライヤーで毛束を乾燥させた。以上の工程後、専門のパネラー5名で肉眼にて染毛効果を評価した。評価は以下の表１に示す基準
により点数を付けて行い、5名の評価の平均値を、染毛効果として、表３〜５に示した。
染毛効果の評価が1.5未満であると実用上好ましくない。一方、評価が2.0以上であると実用上より好ましい。
The first agent was 2g applied to hair dyeing effect shampooing and rinsing the treated hair bundle 1 g (gray hair 100%) and left for 30 ° C., under a relative humidity of 65% in 15 minutes, the second agent was 2g applied again 30 It was left at 15 ° C. and 65% relative humidity for 15 minutes. Thereafter, shampooing and rinsing were performed, and the hair bundle was dried with a dryer. After the above steps, the hair dyeing effect was evaluated with the naked eye by five specialized panelists. Evaluation was performed by assigning points according to the criteria shown in Table 1 below, and the average value of the evaluation of five people was shown in Tables 3 to 5 as the hair dyeing effect.
It is not practically preferable that the evaluation of the hair dyeing effect is less than 1.5. On the other hand, an evaluation of 2.0 or more is more preferable for practical use.
白髪かくし効果
シャンプー及びリンス処理した毛束2g（白髪率20％）に第1剤を4g塗布し、30℃、相対
湿度65％下で15分間放置後、第2剤を4g塗布し、再度30℃、相対湿度65％下で15分間放置
した。その後、シャンプー及びリンス処理し、ドライヤーで毛束を乾燥させた。以上の工程後、専門のパネラー5名で肉眼にて染毛効果を評価した。評価は以下の表２に示す基準
により点数を付けて行い、5名の評価の平均値を、白髪かくし効果として、表３〜５に示
した。
The first agent to white hair hiding effect shampooing and rinsing the treated hair bundle 2 g (gray hair of 20%) and 4g applied and left for 30 ° C., 65% relative humidity for 15 minutes, a second agent to 4g applied again 30 It was left at 15 ° C. and 65% relative humidity for 15 minutes. Thereafter, shampooing and rinsing were performed, and the hair bundle was dried with a dryer. After the above steps, the hair dyeing effect was evaluated with the naked eye by five specialized panelists. Evaluation was performed by assigning points according to the criteria shown in Table 2 below, and the average values of the evaluations of the five persons are shown in Tables 3 to 5 as gray hair combing effects.
白髪かくし効果は、評価が1.0未満であると実用上好ましくない。一方、評価が1.5以上
、特に2.0以上であると実用上より好ましい。
The gray hair combing effect is not practically preferable when the evaluation is less than 1.0. On the other hand, when the evaluation is 1.5 or more, particularly 2.0 or more, it is more practically preferable.
表３に比較例の組成とその確認試験の結果を示す。また、表４及び表５に実施例の組成とその確認試験の結果を示す。 Table 3 shows the composition of the comparative example and the results of the confirmation test. Tables 4 and 5 show the compositions of the examples and the results of the confirmation test.
尚、表３〜５中、第１剤の項目における数値は、第１剤全体を100重量％とした場合の
各成分の配合割合（重量％）を示す。また、第２剤の項目における数値は第２剤全体を100重量％とした場合の各成分の配合割合（重量％）を示す。
In Tables 3 to 5, the numerical value in the item of the first agent indicates the blending ratio (% by weight) of each component when the entire first agent is 100% by weight. Moreover, the numerical value in the item of 2nd agent shows the mixture ratio (weight%) of each component when the 2nd agent whole is 100 weight%.
表３〜５の結果から明らかなように、本発明の組成物（実施例1〜18）においては良好
な染毛効果が得られることがわかった。一方、いずれかの成分を欠く場合（比較例1〜10
）は良好な染毛効果が得られないことがわかった。
As is apparent from the results of Tables 3 to 5, it was found that good hair dyeing effects were obtained in the compositions of the present invention (Examples 1 to 18). On the other hand, when any component is missing (Comparative Examples 1 to 10)
) Was found to have no good hair dyeing effect.
また、表３〜５の結果から明らかなように、本発明の組成物では良好な白髪かくし効果を示すことがわかった。特に尿素を4〜10％含有する本発明の組成物（実施例3〜16）にお
いて良好な白髪かくし効果を示すことがわかった。
Further, as is apparent from the results of Tables 3 to 5, it was found that the composition of the present invention showed a good gray hair combing effect. In particular, it was found that the compositions of the present invention containing 4 to 10% of urea (Examples 3 to 16) showed a good whitening effect.
試験例２（染毛効果及び白髪かくし効果の持続性）
下記表６に示す組成を有する第１剤（A）又は（B）、及び表７に示す組成を有する第２剤からなる染毛剤組成物を以下のように調製し、染毛効果及び白髪かくし効果の持続性を、被験者5名の人頭によるハーフヘッドテストにより評価した。
Test Example 2 (Durability of hair dyeing effect and white hair combing effect)
A hair dye composition comprising the first agent (A) or (B) having the composition shown in Table 6 below and the second agent having the composition shown in Table 7 was prepared as follows, and the hair dyeing effect and white hair were prepared. The persistence of the effect was evaluated by a half head test with 5 human subjects.
（第１剤）
セタノール、ポリオキシエチレン(20)セチルエーテルをビーカー1に量り取り、70℃ま
で加熱し溶解した。別のビーカー2にプロピレングリコールと、没食子酸又はピロガロー
ルを入れ、よく混ぜた後、70℃の精製水、L-アスコルビン酸を加えて攪拌溶解した。ビーカー1にビーカー2を加え乳化し、攪拌しながら冷却し、炭酸水素アンモニウム、水酸化カリウムを加えｐHを7.5に調整し、精製水に溶かした尿素を添加して仕上げた。
(First agent)
Cetanol and polyoxyethylene (20) cetyl ether were weighed into a beaker 1 and heated to 70 ° C. to dissolve. In another beaker 2, propylene glycol and gallic acid or pyrogallol were added and mixed well, and then 70 ° C. purified water and L-ascorbic acid were added and dissolved by stirring. Beaker 2 was added to emulsified beaker 1, cooled while stirring, ammonium bicarbonate and potassium hydroxide were added to adjust pH to 7.5, and urea dissolved in purified water was added to finish.
（第２剤）
セタノール、ポリオキシエチレン(20)セチルエーテルをビーカー3に量り取り、70℃ま
で加熱し溶解した。別のビーカー4に硫酸第一鉄、L-アスコルビン酸を量り取り、70℃の
精製水を加えて攪拌溶解した。ビーカー3にビーカー4を加え乳化し、攪拌しながら冷却し仕上げた。
(Second agent)
Cetanol and polyoxyethylene (20) cetyl ether were weighed into a beaker 3 and heated to 70 ° C. to dissolve. In another beaker 4, ferrous sulfate and L-ascorbic acid were weighed, and purified water at 70 ° C. was added and dissolved by stirring. The beaker 4 was added to the beaker 3 to emulsify, and the mixture was cooled and finished with stirring.
（ハーフヘッドテスト）
被験者5名は全頭の白髪率が50％程度、長さ30cm程度の人を選んだ。上記表６に示す第
１剤（Ａ）及び（Ｂ）並びに表７に示す第２剤を調製し、被験者の左頭部に第1剤（Ａ）
を、右頭部に第1剤（Ｂ）を塗布し、15分間放置した。その後、第2剤を全頭に塗布した。この際、左と右の薬剤が混ざらないように、別々の塗布具を使用した。第2剤塗布後、15
分放置してから水洗、シャンプー、リンスし、ドライヤーで完全に乾かした後、染毛直後の染毛効果及び白髪かくし効果を確認した。その後、被験者には1日に1回シャンプー、リ
ンスしてもらい、1日後、1週間後、2週間後、1ヶ月後に染毛直後の染毛効果及び白髪かくし効果に対する変化を確認した。
(Halfhead test)
Five subjects selected individuals with a white hair rate of about 50% and a length of about 30 cm. The first agent (A) and (B) shown in Table 6 and the second agent shown in Table 7 are prepared, and the first agent (A) is prepared on the subject's left head.
The first agent (B) was applied to the right head and allowed to stand for 15 minutes. Thereafter, the second agent was applied to all the heads. At this time, separate applicators were used so that the left and right drugs were not mixed. After applying the second agent, 15
After leaving it for a minute, it was washed with water, shampooed, rinsed, and completely dried with a dryer, and then the hair coloring effect immediately after hair dyeing and the effect of whitening hair were confirmed. Thereafter, the subjects were allowed to shampoo and rinse once a day, and after 1 day, 1 week, 2 weeks, and 1 month later, changes in the hair dyeing effect immediately after hair dyeing and changes to the hair whitening effect were confirmed.
確認は専門のパネラー5名で肉眼により表８に示す判断基準で判定し、5名の評価の平均値を染毛効果及び白髪かくし効果の持続性効果として示した。 The confirmation was made by 5 expert panelists with the naked eye according to the judgment criteria shown in Table 8, and the average value of the evaluation of 5 people was shown as the long-lasting effect of the hair dyeing effect and the gray hair combing effect.
評価結果を、下記表９に示す。 The evaluation results are shown in Table 9 below.
表９に示されるように、本発明である第１剤（Ａ）を用いた染毛組成物の場合において、染毛効果及び白髪かくし効果の優れた持続性が奏されることが確認された。 As shown in Table 9, in the case of the hair dye composition using the first agent (A) of the present invention, it was confirmed that excellent sustainability of the hair dyeing effect and the gray hair combing effect was exhibited. .
試験例３（アレルギー反応性）
表１０に示す染毛剤組成物を以下のように調製し、アレルギー反応の有無に関して、ジアミン系酸化染料によってかぶれが生じる被験者5名の右上腕部を用いて、パッチ試験を
実施した。
Test example 3 (allergic reactivity)
The hair dye composition shown in Table 10 was prepared as follows, and a patch test was conducted using the right upper arm of five test subjects who were rashed by a diamine-based oxidation dye for the presence or absence of an allergic reaction.
（第1剤）
セタノール、ポリオキシエチレン(20)セチルエーテルをビーカー1に量り取り、70℃ま
で加熱し溶解した。別のビーカー2にプロピレングリコールと没食子酸を入れ、よく混ぜ
た後、70℃の精製水、サリチル酸ナトリウム、L-アスコルビン酸を加えて攪拌溶解した。ビーカー1にビーカー2を加え乳化し、攪拌しながら冷却し、炭酸水素アンモニウム、水酸化カリウムを加えｐHを7.5に調整し、精製水に溶かした尿素を添加して仕上げた。
(First agent)
Cetanol and polyoxyethylene (20) cetyl ether were weighed into a beaker 1 and heated to 70 ° C. to dissolve. In another beaker 2, propylene glycol and gallic acid were added and mixed well, and then 70 ° C. purified water, sodium salicylate, and L-ascorbic acid were added and dissolved by stirring. Beaker 2 was added to emulsified beaker 1, cooled while stirring, ammonium bicarbonate and potassium hydroxide were added to adjust pH to 7.5, and urea dissolved in purified water was added to finish.
（第２剤）
セタノール、ポリオキシエチレン(20)セチルエーテルをビーカー3に量り取り、70℃ま
で加熱し溶解した。別のビーカー4に硫酸第一鉄、L-アスコルビン酸を量り取り、70℃の
精製水を加えて攪拌溶解した。ビーカー3にビーカー4を加え乳化し、攪拌しながら冷却して仕上げた。得られた液のｐHは3程度であった。
(Second agent)
Cetanol and polyoxyethylene (20) cetyl ether were weighed into a beaker 3 and heated to 70 ° C. to dissolve. In another beaker 4, ferrous sulfate and L-ascorbic acid were weighed, and purified water at 70 ° C. was added and dissolved by stirring. The beaker 4 was added to the beaker 3 to emulsify, and the mixture was cooled with stirring to finish. The pH of the obtained liquid was about 3.
〔パッチ試験〕
調製した表１０に示す第1剤1gと第2剤1gを混ぜた。
[Patch test]
1 g of the first agent and 1 g of the second agent prepared in Table 10 were mixed.
1枚×6パッドからなるパッチテスト用テープ（リバテープ製薬株式会社製、レギューラーサイズ）を1枚×4パッドにカットし、先に用意した第1剤と第2剤の混合物を1パッド当
たり0.1gずつ塗布した後、被験者の右上腕部に貼付けた。その後、48時間でテープを取り、軽く水で洗い、1時間放置した後、第1剤と第2剤の混合物の接触部位を肉眼で確認し、
紅斑の有無を判定した。この試験を被験者5名に実施された。
Cut the patch test tape (regular size, manufactured by Riba Tape Pharmaceutical Co., Ltd.) consisting of 1 sheet x 6 pads into 1 sheet x 4 pads, and 0.1 g per pad of the mixture of the first and second agents prepared earlier After each application, it was attached to the upper right arm of the subject. After that, take the tape in 48 hours, lightly wash with water, leave it for 1 hour, then visually check the contact site of the mixture of the first and second agent,
The presence or absence of erythema was determined. This test was conducted on five subjects.
［結果］
パッチ試験の結果、被験者5名に、アレルギー反応と考えられる紅斑、発疹、水疱等の
異常は見られなかった。
[result]
As a result of the patch test, no abnormalities such as erythema, rash and blisters, which were considered to be allergic reactions, were observed in 5 subjects.
パッチ試験の結果より、本発明品はジアミン系酸化染料によってかぶれが生じる使用者にも適用できることがわかった。 From the results of the patch test, it was found that the product of the present invention can be applied to users who are rashed by a diamine-based oxidation dye.
Claims (1)
第１剤が、
（ｉ）没食子酸及びその誘導体からなる群から選ばれる1以上、及び／又は、
（ii）サリチル酸及びその誘導体からなる群より選ばれる1以上
を含んでなり、
第２剤が、鉄塩を含んでなり、かつ、
第１剤及び第２剤のうち少なくとも一方が、尿素を含んでいる
組成物。 A two-component hair dye composition comprising a first agent and a second agent,
The first agent
(I) one or more selected from the group consisting of gallic acid and derivatives thereof, and / or
(Ii) comprising one or more selected from the group consisting of salicylic acid and derivatives thereof,
The second agent comprises an iron salt, and
A composition in which at least one of the first agent and the second agent contains urea.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016072062A1 (en) * | 2014-11-05 | 2016-05-12 | Henkel Ag & Co. Kgaa | Hair dye |
| WO2016072061A1 (en) * | 2014-11-05 | 2016-05-12 | Henkel Ag & Co. Kgaa | Hair dye |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6233113A (en) * | 1985-08-05 | 1987-02-13 | Kyodo Seiyakushiyo:Kk | Hair dye |
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2012
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6233113A (en) * | 1985-08-05 | 1987-02-13 | Kyodo Seiyakushiyo:Kk | Hair dye |
Non-Patent Citations (2)
| Title |
|---|
| CSNC200800957015; 最新ヘアカラー技術-特許にみる開発動向、フレグランスジャーナル社、２００４年８月２５日、第１版、１８０〜１９１頁 * |
| JPN6013053372; 最新ヘアカラー技術-特許にみる開発動向、フレグランスジャーナル社、２００４年８月２５日、第１版、１８０〜１９１頁 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016072062A1 (en) * | 2014-11-05 | 2016-05-12 | Henkel Ag & Co. Kgaa | Hair dye |
| WO2016072061A1 (en) * | 2014-11-05 | 2016-05-12 | Henkel Ag & Co. Kgaa | Hair dye |
| JP2016088890A (en) * | 2014-11-05 | 2016-05-23 | ヘンケルジャパン株式会社 | Hair dye |
| JP2016088889A (en) * | 2014-11-05 | 2016-05-23 | ヘンケルジャパン株式会社 | Hair dye |
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