JP2013022338A - Biological component measuring device and biological component measuring method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a biological component measuring device which non-invasively performs high accuracy biological component measuring, and to provide a biological component measuring method.SOLUTION: The biological component measuring device 10 includes: a guide plate 11 where a part of a living body 20 is placed; a light source 18 for generating light to pass through the living body placed on the guide plate 11 in the width direction of the guide plate 11; a light reception part 19 for receiving the light coming through the living body 20; optical path change parts 15a, 15b, 16a, 16b for changing an optical path between the light source 18 and the light reception part 19; and a control part 17. The control part 17 determines the optimum optical path, on the basis of an OCT image or the intensity of scattered light, etc., controls the optical path change parts 15a, 15b, 16a, 16b to allow the light emitted from the light source 18 to pass through the optimum optical path, and measures a biological component, on the basis of a signal to be output from the light reception part 19.

Description

  The present invention relates to a biological component measuring apparatus and a biological component measuring method.

  Information such as blood pressure, blood oxygen saturation, and blood glucose level is important for knowing the patient's condition, and also serves as a material for determining the timing of medication. In general, biological information such as blood oxygen saturation and blood glucose level is obtained from blood collected from the living body. In diabetic patients admitted to hospitals, blood collection needles (blood collection needles) are always attached to the human body. Blood is collected regularly after being inserted. In addition, in the case of a diabetic patient undergoing outpatient treatment, blood must be collected and examined about 3 to 4 times a day.

  However, blood collection with a needle is accompanied by mental and physical pain. For this reason, a non-invasive method for measuring biological components has been proposed. For example, a method is known in which a finger or the like is irradiated with near infrared light and the glucose concentration (blood glucose level) in blood is measured from the intensity of transmitted light.

JP 2008-291550 A JP 2000-189391 A JP 2001-087249 A JP 2005-106592 A

  An object of the present invention is to provide a biological component measuring apparatus and a biological component measuring method that can measure biological components accurately and non-invasively.

  According to one aspect of the disclosed technology, a guide plate for placing a part of a living body, and a light source that generates light that passes through the living body placed on the guide plate in the width direction of the guide plate. A light receiving unit for receiving light transmitted through the living body, an optical path changing unit for changing an optical path between the light source and the light receiving unit, and determining an optimum optical path, and the light emitted from the light source is the optimum light There is provided a biological component measuring apparatus including a control unit that controls the optical path changing unit so as to pass through an optical path and measures a biological component based on a signal output from the light receiving unit.

  According to another aspect of the disclosed technology, a step of placing a part of a living body on a guide plate, a step of determining an optimal optical path, and a living body on the guide plate along the optimal optical path There is provided a biological component measurement method including a step of transmitting light through a portion and a step of calculating a biological component from an output of a light receiving unit that receives light transmitted through the biological portion.

  According to the living body component measuring apparatus and living body component measuring method according to the above aspect, the living body component can be accurately measured by a non-invasive method that transmits light into the living body.

FIG. 1 is a schematic diagram showing a biological component measuring apparatus according to the first embodiment. FIG. 2 is a schematic diagram illustrating the first light source and the first light receiving unit. FIG. 3 is a diagram illustrating an example of a finger vein pattern obtained by processing a signal output from the first light receiving unit. FIG. 4 is a schematic diagram showing a tomographic information acquisition unit. 5A and 5B are diagrams illustrating an example of a tomographic image obtained by the tomographic information acquisition unit. FIG. 6 is a schematic diagram showing a movable column and a mirror. FIG. 7 is a flowchart showing a method for measuring a biological component by the biological component measuring apparatus according to the first embodiment. FIG. 8 is a diagram schematically showing the optimum optical path candidate. FIG. 9 is an image diagram showing an optimum optical path. FIGS. 10A and 10B are image diagrams for explaining the adjustment of the optical path. FIG. 11 is a schematic diagram illustrating a biological component measurement apparatus according to the second embodiment. FIG. 12 is a flowchart illustrating a method for measuring a biological component by the biological component measuring apparatus according to the second embodiment.

  Hereinafter, before describing the embodiment, a preliminary matter for facilitating understanding of the embodiment will be described.

  2. Description of the Related Art Conventionally, a method is known in which a human body (for example, a finger) is irradiated with near-infrared light, and the glucose concentration (blood glucose level) in blood is calculated from the intensity of light transmitted through the human body.

  However, in this method, melanin and blots that are present on the surface layer of the skin, and fat, bones, muscles, arteries, and the like that are deeper than subcutaneous fat become scattering factors that scatter light. When light passes through an optical path with many scattering factors, the SN ratio (signal-to-noise ratio) becomes small, and the measurement accuracy decreases. Therefore, in the method of measuring biological components (such as glucose concentration) by irradiating light, it is important to select an optical path that has as few light scattering factors as possible.

  In the measurement of biological components, for example, measurement of glucose concentration in blood for a diabetic patient may be required multiple times per day. In such a case, if the measurement position changes for each measurement, the light scattering state changes and the measurement results vary. Therefore, it is important to always measure biological components under the same conditions (same optical path).

  In the following embodiments, a living body component measuring apparatus and a living body component measuring method capable of measuring living body components with high accuracy in a noninvasive manner will be described.

(First embodiment)
FIG. 1 is a schematic diagram showing a biological component measuring apparatus according to the first embodiment. In addition, the white arrow in FIG. 1 and the arrow of a broken line have shown the path | route of light.

  The biological component measuring apparatus 10 includes a guide plate 11, a first light source 12, a first light receiving unit 13, a tomographic information acquisition unit 14, movable columns 15a and 15b, mirrors 16a and 16b, and a control unit 17. And a second light source 18 and a second light receiving unit 19. The control unit 17 is realized using, for example, a computer. The control unit 17 includes an operation panel 17a including various operation keys and a display device.

  The guide plate 11 is a transparent plate formed of, for example, acrylic or glass, and a biological examination site is brought into contact with the guide plate 11 when measuring biological components. In the present embodiment, the subject's finger 20 is placed on the guide plate 11.

  Below the guide plate 11, the first light source 12 and the first light receiving unit 13 are arranged separately in the width direction of the guide plate 11 (the same direction as the width direction of the finger 20 in FIG. 1). In the present embodiment, a measurement site feature shape acquisition unit is configured by the first light source 12, the first light receiving unit 13, and the control unit 17.

  FIG. 2 is a schematic diagram showing the first light source 12 and the first light receiving unit 13.

  In the present embodiment, a light emitting diode (LED) that emits near infrared light is used as the first light source 12, and a charge coupled device (CCD) or the like is used as the first light receiving unit 13. Use an image sensor.

  When a predetermined signal is transmitted from the control unit 17, the first light source 12 irradiates near-infrared light having a wavelength of, for example, 700 nm to 1200 nm toward the finger 20 on the guide plate 11. Near-infrared light of this wavelength has the property that it can easily enter living tissue and is easily absorbed by hemoglobin in blood. Accordingly, the near infrared light is irradiated onto the finger 20, the near infrared light reflected by the finger 20 is received by the first light receiving unit 13, and a signal output from the first light receiving unit 13 is transmitted to the control unit 17. When the signal processing is performed, a vein pattern indicating a vein pattern is obtained. FIG. 3 shows an example of a finger vein pattern obtained by processing the signal output from the first light receiving unit 13.

  The vein pattern is biometric information unique to each person, and can be used for personal authentication that identifies an individual. In the present embodiment, a vein pattern acquired using the first light source 12 and the first light receiving unit 13 is used as a measurement site characteristic shape. For example, a contour image of the finger 20 or a fingerprint pattern is acquired to measure the site of measurement. It may be a characteristic shape.

  As shown in FIG. 1, the tomographic information acquisition unit 14 is also disposed below the guide plate 11. The tomographic information acquisition unit 14 includes a light source, a light receiving element, a signal processing unit, and the like (all not shown), and uses a well-known OCT (Optical Coherence Tomography :) to acquire a tomographic image inside the living body using the coherence of light. The tomographic information of the living body is acquired using optical tomography technology.

  FIG. 4 is a schematic diagram showing the tomographic information acquisition unit 14. The tomographic information acquisition unit 14 starts operation in response to a predetermined signal sent from the control unit 17. Then, tomographic images of various depths of the finger 20 placed on the guide plate 11 are acquired and transmitted to the control unit 17 as tomographic information. The tomographic information transmitted to the control unit 17 includes information on the position and size of scattering factors such as irregularities (fingerprints and scratches) on the skin surface, sweat glands, hair roots, sebaceous glands, and collagen layers.

  FIGS. 5A and 5B are diagrams illustrating an example of a tomographic image obtained by the tomographic information acquisition unit 14.

  FIG. 5A is a transverse layer image of the surface layer portion of the skin. As can be seen from FIG. 5A, the fingerprint pattern can be identified from the tomographic image obtained by the tomographic information acquisition unit 14. FIG. 5B is a vertical cross-sectional image near the surface of the skin. As can be seen from FIG. 5B, the sweat gland and the collagen layer can be identified from the tomographic image obtained by the tomographic information acquisition unit 14.

  FIG. 6 is a schematic diagram showing the movable columns 15a and 15b and the mirrors 16a and 16b.

  As shown in FIG. 6, guide rails 31 a and 31 b extending in the length direction of the guide plate 11 are provided on both sides in the width direction of the guide plate 11. The movable columns 15a and 15b are arranged with their longitudinal directions vertical, and are driven by a drive unit (not shown) controlled by the control unit 17 to move on the guide rails 31a and 31b.

  A mirror 16a is attached to the movable column 15a, and a mirror 16b is attached to the movable column 15b. These mirrors 16 a and 16 b are driven by a drive unit (not shown) controlled by the control unit 17, and the angle changes. The mirrors 16a and 16b may be moved in the height direction of the movable columns 15a and 15b in accordance with a signal from the control unit 17.

  As shown in FIG. 1, a second light source 18 is disposed below the mirror 16a, and a second light receiving unit 19 is disposed below the mirror 16b. The second light source 18 and the second light receiving unit 19 are used for measuring biological components.

  When a predetermined signal is sent from the control unit 17, the second light source 18 emits light toward the mirror 16a. For example, a laser diode (LD) is used as the second light source 18 and emits light having two or more wavelengths in a wavelength region from a visible light region to an infrared light region. However, the light emitted from the second light source 18 includes light having a wavelength that is easily absorbed by glucose. In the present embodiment, it is assumed that light having a wavelength of 940 nm and light having a wavelength of 1060 nm are emitted from the second light source 18.

  The second light source 18 does not have to be formed by one light emitting element, and may be formed by, for example, a plurality of light emitting elements. In that case, for example, light generated by a plurality of light emitting elements may be mixed by a coupler and emitted through an optical fiber.

  The light emitted from the second light source 18 is reflected by the mirror 16a, passes through the finger 20 in the width direction, reaches the mirror 16b, is further reflected by the mirror 16b, and travels toward the second light receiving unit 19. When light passes through the finger 20, light having a specific wavelength is absorbed by glucose in blood passing through the inside of the finger 20.

  The second light receiving unit 19 has one or a plurality of light receiving elements and receives light reflected by the mirror 16b. For example, an InGaAs photodetector (PD) can be used for the second light receiving unit 19. The second light receiving unit 19 outputs a signal corresponding to the light amount for each wavelength to the control unit 17.

  FIG. 7 is a flowchart showing a method for measuring a biological component by the biological component measuring apparatus according to the first embodiment.

  First, in step S <b> 11, the subject's finger 20 is placed on the guide plate 11. Then, the controller 17 is instructed to start measurement via the operation panel 17a.

  In addition, if the pressure with respect to the guide plate 11 of the finger 20 changes at every inspection, accurate measurement becomes difficult. Therefore, a pressure sensitive element is provided on the guide plate 11 to detect the pressure of the finger 20, and when the finger 20 is pressed against the guide plate 11 excessively, a message for calling attention is displayed on the display unit of the operation panel 17a. It may be.

  Next, in step S <b> 12, the control unit 17 outputs a predetermined signal to the first light source 12 to turn on the first light source 12. Thereby, the near-infrared light emitted from the first light source 12 passes through the guide plate 11 and enters the finger 20. At this time, a part of the near infrared light is absorbed by hemoglobin in the blood flowing through the vein. Then, near infrared light reflected inside the finger 20 passes through the guide plate 11 and is received by the first light receiving unit 13. The control unit 17 processes the signal output from the first light receiving unit 13 and acquires the vein pattern (measured site feature shape) of the finger 20.

  Next, in step S13, the control unit 17 determines whether or not it is the first measurement. Specifically, the control unit 17 checks whether or not the vein pattern acquired in step S12 is already registered in the control unit 17. When not registered, it determines with it being the 1st measurement (YES), and transfers to step S14. If it has already been registered, it is determined NO (NO), and the process proceeds to step S20.

  Note that the determination method in step S13 is not limited to the above-described method. For example, the user may input whether or not it is the first measurement by operating an operation key on the operation panel 17a. In addition, for example, personal information such as a name, fingerprint information, or password for each user is registered in the control unit 17 in advance, personal authentication is performed using the name, fingerprint information, password, or the like, and measurement has been performed in the past. You may make it determine whether it is a certain subject.

  In step S14, the control unit 17 registers (stores) the vein pattern acquired in step S12. In this case, it is preferable to store the vein pattern and the personal information of the subject such as a name in association with each other.

  Next, the process proceeds to step S15, and the control unit 17 instructs the tomographic information acquisition unit 14 to acquire tomographic information (OCT measurement). Thereby, the tomographic information acquisition unit 14 takes tomographic images of various depths of the finger 20 and transmits the tomographic information to the control unit 17 as tomographic information. This tomographic information includes information on the position and size of parts that cause light scattering, such as irregularities (fingerprints and scratches) on the skin surface, sweat glands, hair roots, sebaceous glands, and collagen layers.

  The scanning range when the tomographic information acquisition unit 14 acquires a tomographic image of the finger 20 is, for example, a range from the reference position to 3 cm in the length direction of the finger 20. The depth range is not particularly limited. For example, the depth range may be a range of several mm upward from the surface of the guide plate 11.

  Next, the process proceeds to step S <b> 16, and the control unit 17 determines an optimal optical path (hereinafter referred to as “optimal optical path”) for measuring biological components based on the tomographic information. The method will be described below.

  A plurality of (for example, several hundreds or more) optimum optical path candidates are registered in the control unit 17 in advance. FIG. 8 is a diagram schematically showing the optimum optical path candidate. As indicated by the arrows in FIG. 8, the optimum optical path candidate has a plurality of patterns having different positions and angles. These optimum optical path candidates are set so that light passes through veins in the dermis layer of the finger 20.

  The control unit 17 refers to the tomographic information to grasp the distribution state of scattering factors such as wounds, sweat glands, hair roots, sebaceous glands, and collagen layers, and selects an optical path with the least scattering factors from among the plurality of optimum optical path candidates described above. Select as the optimal optical path.

  FIG. 9 is an image diagram showing an optimum optical path. The thick line in FIG. 9 represents the outline of the finger 20 and the vein pattern, and the small circle represents the scattering factor. Moreover, the arrow in FIG. 9 represents the optimal optical path. As shown in FIG. 9, the control unit 17 selects an optical path with the smallest scattering factor from among a plurality of optimal optical path candidates as the optimal optical path.

  After the optimum optical path is determined in this way, the process proceeds to step S17, and the control unit 17 stores the optimum optical path in association with the vein pattern (measurement site feature shape). By associating the optimal optical path with the vein pattern, even if the position of the finger 20 placed on the guide plate 11 is shifted from the first measurement at the next measurement, the registered vein pattern is compared with the vein pattern at the next measurement. By doing so, the amount of deviation is known. Thereby, it is possible to transmit light to the same position (optimum optical path) as in the first measurement without newly acquiring tomographic information. When the amount of deviation is large, a message may be displayed on the display unit of the operation panel 17a so as to shift the position of the finger.

  Next, in step S18, the control unit 17 determines the position of the movable columns 15a and 15b and the mirror so that the light emitted from the first light source 18 reaches the second light receiving unit 19 through the optimum optical path. The optical path is adjusted by changing the angles of 16a and 16b.

  FIGS. 10A and 10B are image diagrams for explaining the adjustment of the optical path. As shown in FIG. 10 (a), the positions of the movable columns 15a and 15b are individually adjusted, and the angles of the mirrors 16a and 16b are individually adjusted as shown in FIG. 10 (b). Can pass through.

  After adjusting the optical path in this way, the process proceeds to step S19, where the control unit 17 emits light from the second light source 18, and based on the signal output from the second light receiving unit 19, the biological component (Glucose concentration) is measured. That is, the control unit 17 examines the intensity for each wavelength of the light received by the second light receiving unit 19 and calculates the glucose concentration from the ratio of these intensities. Since the amount of light absorbed by glucose is related to the wavelength of light, as described above, the glucose concentration can be calculated from the ratio of the intensities of light having different wavelengths. The measurement result of the biological component is displayed on, for example, a display unit provided on the operation panel 17a, and is stored in the control unit 17 together with the measurement date / time information.

  On the other hand, if it is determined in step S13 that it is not the first measurement, the process proceeds to step S20. In step S <b> 20, the control unit 17 reads registration information, that is, information about the subject's vein pattern (measurement site feature shape) and information on the optimum optical path associated therewith. Thereafter, the process proceeds to step S18, and as described above, the positions of the movable columns 15a and 15b and the angles of the mirrors 16a and 16b are adjusted based on the vein pattern and the information on the optimum optical path associated therewith. Measure.

  In this embodiment, a biological component can be measured non-invasively without giving the subject pain such as inserting a blood collection needle. Moreover, in this embodiment, since a biological component is measured by an optical method without damaging a living body, the place of use is not limited to a medical facility such as a hospital, and it can be used in a home or a public facility.

  Further, in the present embodiment, the tomographic information acquisition unit 14 acquires the tomographic information of the living body, examines the distribution of the scattering factors based on the tomographic information, and moves the movable columns 15a and 15b so that the light passes through the optical path with few scattering factors. And the angles of the mirrors 16a and 16b are adjusted. Thereby, the fall of SN ratio is avoided and a biological component can be measured accurately.

  Furthermore, since the biological component measurement apparatus 10 according to the present embodiment stores the optimum optical path in association with the measurement site feature shape such as a vein pattern, the light can always pass through the same position. For this reason, when investigating the change of a biological component with time, the reliability of the measurement result is high.

  In the present embodiment, the second light source 18 and the second light receiving unit 19 are both disposed below the guide plate 11, but at least one of the second light source 18 and the second light receiving unit 19 is provided. It may be arranged above the guide plate 11.

  In the present embodiment, the movable columns 15a and 15b to which the mirrors 16a and 16b are attached move along the guide rails 31a and 31b. However, the mirrors 16a and 16b, the movable columns 15a and 15b, and the guide rails are used. 31a and 31b are not essential. For example, the mirror 16a can be omitted by attaching the second light source 18 to the movable column 15a. Further, for example, a large number of light emitting elements (second light sources) are arranged along the guide plate 11 on one side in the width direction of the guide plate 11, and a large number of light receiving elements (first light sources) along the guide plate 11 on the other side. 2), the movable columns 15a and 15b and the guide rails 16a and 16b can be omitted.

  Furthermore, in the present embodiment, the processes in steps S14 to S17 are omitted for the second and subsequent measurements. However, when a certain amount of time (for example, more than half a year) has elapsed since the previous measurement, the processing in steps S14 to S17 may be executed in the same manner as in the first measurement.

(Second Embodiment)
FIG. 11 is a schematic diagram illustrating a biological component measurement apparatus according to the second embodiment. The present embodiment is different from the first embodiment in that it has a scattered light sensor 41 instead of the tomographic information acquisition unit 14, and other configurations are basically the same as those of the first embodiment. Therefore, in FIG. 11, the same components as those in FIG. 1 are denoted by the same reference numerals, and detailed description thereof is omitted.

  As shown in FIG. 11, in the biological component measurement apparatus 40 according to the present embodiment, the scattered light sensor 41 is disposed below the guide plate 11. The scattered light sensor 41 receives scattered light when the light emitted from the second light source 18 passes through the inside of the finger 20 and outputs a signal corresponding to the amount of received light to the control unit 17. As the scattered light sensor 41, a photodetector (PD), a CCD, or the like can be used.

  FIG. 12 is a flowchart showing a method for measuring a biological component by the biological component measuring apparatus according to this embodiment.

  First, in step S <b> 21, the subject's finger 20 is placed on the guide plate 11. Then, the controller 17 is instructed to start measurement via the operation panel 17a.

  Next, it transfers to step S22 and the control part 17 outputs a predetermined signal to the 1st light source 12, and makes the 1st light source 12 light. Thereby, the near-infrared light emitted from the first light source 12 passes through the guide plate 11 and enters the finger 20. Then, near infrared light reflected inside the finger 20 passes through the guide plate 11 and is received by the first light receiving unit 13. The control unit 17 processes the signal output from the first light receiving unit 13 and acquires the vein pattern (measured site feature shape) of the finger 20.

  Next, in step S23, the control unit 17 checks whether it is the first measurement, that is, whether the vein pattern acquired in step S22 is already registered in the control unit 17. If the acquired vein pattern is not registered, it is determined that the measurement is the first measurement (YES), and the process proceeds to step S24. If the acquired vein pattern is already registered, it is determined NO (NO), and the process proceeds to step S30.

  In step S24, the control unit 17 registers (stores) the vein pattern acquired in step S22. In this case, it is preferable to store the vein pattern and the personal information of the subject such as a name in association with each other.

  Next, the process proceeds to step S25, where the control unit 17 searches for an optimum optical path. That is, the control unit 17 sequentially reads out a plurality of optimum optical path candidates registered in advance (see FIG. 8), and adjusts the positions of the movable columns 15a and 15b and the angles of the mirrors 16a and 16b for each of the read optimum optical path candidates. . Then, the light emitted from the second light source 18 is actually passed through the optimum light path candidates, and the intensity of the scattered light is measured by the scattered light sensor 41 for each optimum light path candidate.

  As the scattering factor increases in the optical path, the intensity of the scattered light detected by the scattered light sensor 41 increases. In this embodiment, after all light passes through the registered optimum optical path candidates, the optimum optical path candidate having the lowest scattered light intensity is set as the optimum optical path.

  After the optimal optical path is determined in this way, the process proceeds to step S27, and the control unit 17 stores the optimal optical path in association with the vein pattern (measurement site feature shape). Thereafter, the process proceeds to step S28, and the control unit 17 determines the positions of the movable columns 15a and 15b so that the light emitted from the first light source 18 reaches the second light receiving unit 19 through the optimum optical path, and The optical path is adjusted by changing the angles of the mirrors 16a and 16b.

  Subsequently, the process proceeds to step S29, where the control unit 17 emits light from the second light source 18, and calculates a biological component (glucose concentration) based on the signal output from the second light receiving unit 19. The calculation result (measurement result) of the biological component is displayed on, for example, a display unit provided on the operation panel 17a, and is stored in the control unit 17 together with information on the measurement date.

  On the other hand, if it is determined in step S23 that it is not the first measurement, the process proceeds to step S30. In step S30, the control unit 17 reads registration information, that is, information on the subject's vein pattern (measurement site feature shape) and information on the optimum optical path associated therewith. Thereafter, the process proceeds to step S28, where the positions of the movable columns 15a, 15b and the angles of the mirrors 16a, 16b are adjusted based on the vein pattern and the information on the optimum optical path associated therewith as described above. Measure.

  In the first embodiment, since the tomographic information acquisition unit 14 that acquires a tomographic image by OCT is used, it is conceivable that the apparatus configuration becomes complicated and the cost increases. On the other hand, in the present embodiment, since the scattered light sensor 41 formed by a relatively inexpensive photo detector or CCD is used, there is an advantage that the apparatus cost is reduced as compared with the first embodiment. Also in the present embodiment, as in the first embodiment, there is an effect that it is possible to accurately measure biological components non-invasively.

  The following additional notes are disclosed with respect to the above embodiments.

(Appendix 1) a guide plate for placing a part of a living body;
A light source that generates light that passes through the living body placed on the guide plate in the width direction of the guide plate;
A light receiving unit that receives light transmitted through the living body;
An optical path changing unit that changes an optical path between the light source and the light receiving unit;
A control unit that determines an optimal optical path, controls the optical path changing unit so that light emitted from the light source passes through the optimal optical path, and measures a biological component based on a signal output from the light receiving unit; A biological component measuring apparatus comprising:

(Additional remark 2) It has a tomographic image acquisition part which acquires the three-dimensional tomographic image of the living body part arranged under the guide plate and placed on the guide plate,
The biological component measuring apparatus according to claim 1, wherein the control unit determines the optimum optical path based on the three-dimensional tomographic image acquired by the tomographic image acquisition unit.

  (Supplementary Note 3) The control unit refers to the three-dimensional tomographic image, and sets, as the optimum optical path, an optical path having a small scattering factor that scatters light among a plurality of optimum optical path candidates registered in advance. The biological component measuring apparatus according to Appendix 2.

(Additional remark 4) It has the scattered light detection part which detects the light scattered under the living body arranged under the guide board,
The biological component measuring apparatus according to appendix 1, wherein the control unit determines the optimum optical path based on an output of the scattered light detection unit.

  (Additional remark 5) The said control part makes the said optical path the optical path with few light quantities detected by the said scattered light detection part from the several optimal optical path candidates registered beforehand, The additional light 4 characterized by the above-mentioned. Biological component measuring device.

(Additional remark 6) Furthermore, it has a measurement site | part feature shape acquisition part which acquires either a vein pattern, the outline image of a biological body, or a fingerprint pattern as a measurement site | part feature shape of the biological body mounted on the said guide plate. And
The biological component measuring apparatus according to any one of appendices 1 to 5, wherein the control unit stores the position of the optimum optical path in association with the measurement site feature shape.

(Appendix 7) placing a part of a living body on a guide plate;
Determining an optimal optical path;
Transmitting light to the living body portion on the guide plate along the optimum optical path;
And calculating a biological component from an output of a light receiving unit that receives light transmitted through the biological part.

(Appendix 8) In the step of determining the optimum optical path,
Acquiring a three-dimensional tomographic image of a living body part on the guide plate by a tomographic image acquiring unit disposed under the guide plate;
The biological component measuring method according to appendix 7, wherein an optical path with few scattering factors that scatter light is extracted from the three-dimensional tomographic image to obtain an optimum optical path.

(Supplementary Note 9) In the step of determining the optimum optical path,
Additional note, wherein an optimum optical path is extracted by extracting an optical path having a low intensity of scattered light detected by a scattered light detection unit disposed under the guide plate from a plurality of optimum optical path candidates registered in advance. 8. The biological component measuring method according to 7.

  DESCRIPTION OF SYMBOLS 10, 40 ... Biological component measuring apparatus, 11 ... Guide board, 12 ... 1st light source, 13 ... 1st light-receiving part, 14 ... Tomographic information acquisition part, 15a, 15b ... Movable column, 16a, 16b ... Mirror, 17 ... Control part, 17a ... Operation panel, 18 ... Second light source, 19 ... Second light receiving part, 20 ... Finger, 31a, 31b ... Guide rail, 41 ... Scattered light sensor.

Claims (5)

A guide plate for placing a part of the living body;
A light source that generates light that passes through the living body placed on the guide plate in the width direction of the guide plate;
A light receiving unit that receives light transmitted through the living body;
An optical path changing unit that changes an optical path between the light source and the light receiving unit;
A control unit that determines an optimal optical path, controls the optical path changing unit so that light emitted from the light source passes through the optimal optical path, and measures a biological component based on a signal output from the light receiving unit; A biological component measuring apparatus comprising: A tomographic image acquisition unit configured to acquire a three-dimensional tomographic image of a living body portion disposed under the guide plate and placed on the guide plate;
The biological component measuring apparatus according to claim 1, wherein the control unit determines the optimum optical path based on the three-dimensional tomographic image acquired by the tomographic image acquisition unit. A scattered light detection unit that is disposed under the guide plate and detects light scattered in the living body;
The biological component measuring apparatus according to claim 1, wherein the control unit determines the optimum optical path based on an output of the scattered light detection unit. Furthermore, it has a measurement site feature shape acquisition unit that acquires any of a vein pattern, a contour image of a living body, and a fingerprint pattern as a measurement site feature shape of a living body placed on the guide plate,
The biological component measuring apparatus according to any one of claims 1 to 3, wherein the control unit stores an optimum optical path position in association with the measurement site feature shape. Placing a part of the living body on the guide plate;
Determining an optimal optical path;
Transmitting light to the living body portion on the guide plate along the optimum optical path;
And calculating a biological component from an output of a light receiving unit that receives light transmitted through the biological part.

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