JP2012522010A5 - - Google Patents
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- Publication number
- JP2012522010A5 JP2012522010A5 JP2012502303A JP2012502303A JP2012522010A5 JP 2012522010 A5 JP2012522010 A5 JP 2012522010A5 JP 2012502303 A JP2012502303 A JP 2012502303A JP 2012502303 A JP2012502303 A JP 2012502303A JP 2012522010 A5 JP2012522010 A5 JP 2012522010A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- spore surface
- peptide
- acid sequence
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 35
- 108090000765 processed proteins & peptides Proteins 0.000 claims 31
- 102000018697 Membrane Proteins Human genes 0.000 claims 30
- 108010052285 Membrane Proteins Proteins 0.000 claims 30
- 241000193163 Clostridioides difficile Species 0.000 claims 28
- 125000003275 alpha amino acid group Chemical group 0.000 claims 28
- 230000003042 antagnostic effect Effects 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 19
- 208000015181 infectious disease Diseases 0.000 claims 11
- 108010033276 Peptide Fragments Proteins 0.000 claims 9
- 102000007079 Peptide Fragments Human genes 0.000 claims 9
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical group 0.000 claims 5
- 239000000758 substrate Substances 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 230000027455 binding Effects 0.000 claims 4
- 230000000813 microbial effect Effects 0.000 claims 4
- 230000009870 specific binding Effects 0.000 claims 3
- 241000193403 Clostridium Species 0.000 claims 2
- 230000004888 barrier function Effects 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 230000002924 anti-infective effect Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 244000005700 microbiome Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16415409P | 2009-03-27 | 2009-03-27 | |
| US61/164,154 | 2009-03-27 | ||
| PCT/US2010/028902 WO2010126670A2 (en) | 2009-03-27 | 2010-03-26 | Compositions and methods for screening and using compounds antagonizing spore-surface interactions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012522010A JP2012522010A (ja) | 2012-09-20 |
| JP2012522010A5 true JP2012522010A5 (cg-RX-API-DMAC7.html) | 2013-05-09 |
| JP5911421B2 JP5911421B2 (ja) | 2016-05-18 |
Family
ID=43032739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012502303A Active JP5911421B2 (ja) | 2009-03-27 | 2010-03-26 | 組成物及び胞子−表面の相互作用と拮抗する化合物をスクリーニングする方法及び使用する方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100291100A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2411410B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5911421B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20110140128A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102388064A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010241947B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI1014121A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2756760A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2411410T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2544435T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2411410E (cg-RX-API-DMAC7.html) |
| TW (1) | TW201039841A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010126670A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9133251B2 (en) | 2008-02-22 | 2015-09-15 | The Curators Of The University Of Missouri | Bacillus based delivery system and methods of use |
| WO2012075506A2 (en) * | 2010-12-03 | 2012-06-07 | Beth Israel Deaconess Medical Center, Inc. | Methods for predicting and treating infection-induced illnesses and predicting the severity of infection-induced illnesses |
| EP2661500A2 (en) * | 2010-12-29 | 2013-11-13 | Cangene Corporation | Clostridium difficile antigens |
| GB2491117A (en) * | 2011-05-20 | 2012-11-28 | Royal Holloway & Bedford New College | Coat proteins from Clostridium and Bacillus species |
| US9573980B2 (en) * | 2013-03-15 | 2017-02-21 | Spogen Biotech Inc. | Fusion proteins and methods for stimulating plant growth, protecting plants from pathogens, and immobilizing Bacillus spores on plant roots |
| WO2014193237A2 (en) * | 2013-05-30 | 2014-12-04 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | C diff protease |
| WO2015061529A1 (en) * | 2013-10-23 | 2015-04-30 | The Rockefeller University | Compositions and methods for prophylaxis and therapy of clostridium difficile infection |
| GB2525177A (en) * | 2014-04-14 | 2015-10-21 | New Royal Holloway & Bedford | Vaccine |
| IL315468A (en) | 2014-09-17 | 2024-11-01 | Spogen Biotech Inc | Fusion proteins, recombinant bacteria, and methods for using recombinant bacteria |
| CA3019732A1 (en) * | 2016-04-05 | 2017-10-12 | Nch Corporation | Nutrient rich germinant composition and spore incubation method |
| US11400121B2 (en) | 2017-01-05 | 2022-08-02 | The University Of Chicago | Development of new monoclonal antibodies recognizing human prostate-specific membrane antigen (PSMA) |
| BR112020005730A2 (pt) | 2017-09-20 | 2020-10-20 | Spogen Biotech Inc. | proteínas de fusão, membro da família bacillus cereus, fragmentos de exosporium, formulação, semente de planta e métodos para estimular o crescimento de plantas e para entregar uma enzima |
| CN109706101B (zh) * | 2019-02-01 | 2022-10-11 | 东华大学 | 一种嗜冷芽孢八叠球菌及其应用 |
| US11001847B2 (en) | 2019-06-05 | 2021-05-11 | Biovector, Inc. | Aptamers against Clostridium difficile |
| CN110879209A (zh) * | 2019-12-09 | 2020-03-13 | 济南大学 | 一种γ-氨基丁酸的快速检测方法 |
| WO2021211921A2 (en) * | 2020-04-17 | 2021-10-21 | Biovector, Inc. | Methods of reducing or preventing clostridioides difficile colonization |
| CN114395576B (zh) * | 2020-08-31 | 2023-11-14 | 南京工业大学 | 一种提高梭菌中蛋白表达效率的方法 |
| US11898146B2 (en) | 2020-12-03 | 2024-02-13 | Liv Process, Inc. | Aptamers against Clostridium difficile, compositions comprising aptamers against Clostridium difficile and methods of using the same |
| KR20230162685A (ko) * | 2021-03-30 | 2023-11-28 | 아사히 가세이 가부시키가이샤 | 아실 CoA 화합물 환원 활성을 갖는 재조합 폴리펩티드 |
| CN113247946B (zh) * | 2021-04-22 | 2022-07-05 | 哈尔滨工业大学 | 一种自组装纳米生物催化剂及其制备方法和在丁醇生产中的应用 |
| CN113278578B (zh) * | 2021-06-15 | 2022-09-16 | 广西大学 | 一种稻瘟病菌分生孢子的移植方法 |
| CN113308431B (zh) * | 2021-06-15 | 2022-09-16 | 广西大学 | 一种番茄灰霉病菌分生孢子的移植与分散方法 |
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-
2010
- 2010-03-26 DK DK10745031.4T patent/DK2411410T3/en active
- 2010-03-26 CN CN2010800140986A patent/CN102388064A/zh active Pending
- 2010-03-26 TW TW099109076A patent/TW201039841A/zh unknown
- 2010-03-26 AU AU2010241947A patent/AU2010241947B2/en not_active Ceased
- 2010-03-26 PT PT107450314T patent/PT2411410E/pt unknown
- 2010-03-26 EP EP10745031.4A patent/EP2411410B1/en not_active Not-in-force
- 2010-03-26 US US12/748,011 patent/US20100291100A1/en not_active Abandoned
- 2010-03-26 KR KR1020117025319A patent/KR20110140128A/ko not_active Ceased
- 2010-03-26 WO PCT/US2010/028902 patent/WO2010126670A2/en not_active Ceased
- 2010-03-26 JP JP2012502303A patent/JP5911421B2/ja active Active
- 2010-03-26 ES ES10745031.4T patent/ES2544435T3/es active Active
- 2010-03-26 BR BRPI1014121A patent/BRPI1014121A2/pt not_active IP Right Cessation
- 2010-03-26 CA CA2756760A patent/CA2756760A1/en not_active Abandoned