JP2012507997A5 - - Google Patents
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- Publication number
- JP2012507997A5 JP2012507997A5 JP2011535119A JP2011535119A JP2012507997A5 JP 2012507997 A5 JP2012507997 A5 JP 2012507997A5 JP 2011535119 A JP2011535119 A JP 2011535119A JP 2011535119 A JP2011535119 A JP 2011535119A JP 2012507997 A5 JP2012507997 A5 JP 2012507997A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- derived
- component
- cells
- immunoregulatory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 16
- 210000000130 stem cell Anatomy 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 230000004957 immunoregulator effect Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 210000005259 peripheral blood Anatomy 0.000 claims 3
- 239000011886 peripheral blood Substances 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 230000006020 chronic inflammation Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 102000006639 indoleamine 2,3-dioxygenase Human genes 0.000 claims 1
- 108020004201 indoleamine 2,3-dioxygenase Proteins 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 210000002826 placenta Anatomy 0.000 claims 1
- 210000003289 regulatory T cell Anatomy 0.000 claims 1
- 210000004003 subcutaneous fat Anatomy 0.000 claims 1
- 210000003954 umbilical cord Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0820397.8 | 2008-11-07 | ||
| GBGB0820397.8A GB0820397D0 (en) | 2008-11-07 | 2008-11-07 | Cells, nucleic acid constructs, cells comprising said constructs and methods utilizing said cells in the treatment of diseases |
| PCT/EP2009/064788 WO2010052313A1 (en) | 2008-11-07 | 2009-11-06 | Cells, nucleic acid constructs, cells comprising said constructs and methods utilizing said cells in the treatment of diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012507997A JP2012507997A (ja) | 2012-04-05 |
| JP2012507997A5 true JP2012507997A5 (enExample) | 2012-12-20 |
| JP5745419B2 JP5745419B2 (ja) | 2015-07-08 |
Family
ID=40139550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535119A Active JP5745419B2 (ja) | 2008-11-07 | 2009-11-06 | 細胞、核酸構築物、前記構築物を含む細胞、及び疾患の治療において前記細胞を利用する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9012220B2 (enExample) |
| EP (1) | EP2361261B1 (enExample) |
| JP (1) | JP5745419B2 (enExample) |
| KR (1) | KR101666692B1 (enExample) |
| AU (1) | AU2009312700B2 (enExample) |
| CA (1) | CA2742698C (enExample) |
| ES (1) | ES2479540T3 (enExample) |
| GB (1) | GB0820397D0 (enExample) |
| WO (1) | WO2010052313A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0918615D0 (en) * | 2009-10-23 | 2009-12-09 | Cellerix Sa | Cell populations having immunoregulatory activity, methods for the preparation and uses thereof |
| WO2012123401A1 (en) * | 2011-03-11 | 2012-09-20 | Tigenix, S.A. | Cell populations having immunoregulatory activity, method for isolation and uses |
| EP3985106A1 (en) * | 2020-10-16 | 2022-04-20 | Uniwersytet Gdanski | Conditioned regulatory t cell population with enhanced therapeutic potential, method for obtaining of regulatory t cell population and the medical use of regulatory t cell population |
| EP3985105A1 (en) * | 2020-10-16 | 2022-04-20 | Uniwersytet Gdanski | Conditioned regulatory t cell population tregs with enhanced therapeutic potential, method for obtaining of conditioned tregs and the medical use of the tregs population |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395876B1 (en) * | 1997-12-05 | 2002-05-28 | Medical College Of Georgia Research Institute, Inc. | High-affinity tryptophan transporter |
| US20030139361A1 (en) | 2000-01-21 | 2003-07-24 | Kazuhiro Yuda | Drug for gene therapy |
| EP2177601A1 (en) * | 2002-04-12 | 2010-04-21 | Medical College of Georgia Research Institute, Inc | Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance |
| EP1369114A1 (en) | 2002-06-07 | 2003-12-10 | Peter Priv. Doz. Dr. Terness | Use of tryptophan metabolites as pharmaceutical agents |
| ES2368152T3 (es) * | 2005-07-01 | 2011-11-14 | Txcell S.A. | Obtención de células tr1 específicas de antígenos de los alimentos o de autoantígenos a partir de una población de leucocitos o pbmc. |
| CA2623353C (en) | 2005-09-23 | 2017-02-21 | Cellerix, S.L. | Cell populations having immunoregulatory activity, method for isolation and uses |
| WO2007071053A1 (en) * | 2005-12-21 | 2007-06-28 | Universite De Montreal | Markers for memory t cells and uses thereof |
| US20090155311A1 (en) * | 2006-01-07 | 2009-06-18 | Med. College Of Georgia Research Institute, Inc. | Indoleamine 2,3-dioxygenase pathways in the generation of regulatory t cells |
| US20080155704A1 (en) * | 2006-12-22 | 2008-06-26 | King's College London | Methods and Compositions for Determining in vivo Activity of BiP |
| US20100055111A1 (en) * | 2007-02-14 | 2010-03-04 | Med. College Of Georgia Research Institute, Inc. | Indoleamine 2,3-dioxygenase, pd-1/pd-l pathways, and ctla4 pathways in the activation of regulatory t cells |
| US8685728B2 (en) * | 2008-01-31 | 2014-04-01 | Rutgers The State University Of New Jersey | Kit containing stem cells and cytokines for use in attenuating immune responses |
| WO2009155477A1 (en) * | 2008-06-19 | 2009-12-23 | The Trustees Of The University Of Pennsylvania | Inducible regulatory t-cell generation for hematopoietic transplants |
-
2008
- 2008-11-07 GB GBGB0820397.8A patent/GB0820397D0/en not_active Ceased
-
2009
- 2009-11-06 EP EP09748336.6A patent/EP2361261B1/en active Active
- 2009-11-06 CA CA2742698A patent/CA2742698C/en active Active
- 2009-11-06 AU AU2009312700A patent/AU2009312700B2/en active Active
- 2009-11-06 KR KR1020117012368A patent/KR101666692B1/ko active Active
- 2009-11-06 WO PCT/EP2009/064788 patent/WO2010052313A1/en not_active Ceased
- 2009-11-06 JP JP2011535119A patent/JP5745419B2/ja active Active
- 2009-11-06 US US13/128,145 patent/US9012220B2/en active Active
- 2009-11-06 ES ES09748336T patent/ES2479540T3/es active Active
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