JP2012251909A - Autoanalyzer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an autoanalyzer capable of making an arbitrary reagent unusable and easily measuring accuracy management samples after measuring the last patient sample for every reagent bottle when a user finds an abnormality which is speculated to result from a reagent used for measurement from results of measurement of patient samples and accuracy measurement samples, results of calibration measurement and reaction process data.SOLUTION: An autoanalyzer includes: an analysis part 206 which analyzes a sample 202; a display part which displays information about analysis of the sample 202; and a control part which controls the analysis part 206 to perform analysis processing of the sample 202. The control part displays a picture showing information on a reagent 207 to be used in analysis of the sample 202 on the display part, uses a mask instruction of the reagent 207 operated based on the display picture as input, performs mask designation of the reagent 207 on the basis of the input mask instruction of the reagent 207, and does not use the mask designated reagent 207 in the analysis of the sample 202.

Description

  The present invention relates to an automatic analyzer for measuring biological samples such as blood and urine, and more particularly to calibration of measurement results by calibration measurement and accuracy management of measurement results by quality control sample measurement for each reagent used. is there.

  When measuring a patient sample with an automatic analyzer, calibration measurement is performed in advance for each reagent used in the analysis, and a calibration curve for obtaining a concentration of a component to be analyzed is calculated. In addition, the measurement result of the patient sample is guaranteed by periodically measuring the accuracy control sample of known concentration and managing the accuracy of the measurement result.

  In recent years, automatic analyzers that perform qualitative / quantitative analysis of biological samples such as blood and urine have made it possible to analyze various items with a small amount of specimens and reagents with high accuracy due to improved performance. Yes. On the other hand, factors affecting the accuracy of analysis, such as changes in the properties of reagents, are becoming increasingly important, and it is required to maintain these states in the normal range and detect the occurrence of abnormalities and respond appropriately. ing.

  As a conventional technique for detecting such an abnormality, for example, the reference time series data generated using a chemical reaction model in advance is stored, and the reaction process data of the sample is compared with the reference time series data, Absorbance change is approximated by a function that is determined to be abnormal when the divergence is large (see Japanese Patent Application Laid-Open No. 2004-347385 (Patent Document 1)) or a function that is stored in advance, and approximates the actually measured absorbance change. A change in absorbance calculated by the calculated function and determining an abnormality from the magnitude of the deviation [see Japanese Patent Application Laid-Open No. 2006-337125 (Patent Document 2)]. In addition, a function is known in which an apparatus automatically detects an abnormality and adds an alarm to a measurement result to notify the user of the abnormality.

JP 2004-347385 A JP 2006-337125 A

  However, in the above-described prior art, abnormalities in reactions other than the photometric point used for concentration measurement cannot be detected by the apparatus, and an inspection engineer may check the test results and the reaction process and determine that they are abnormal. At this time, even if it is assumed that the cause of the abnormality is caused by the reagent used for the measurement, the conventional automatic analyzer has no designation means for the inspection engineer to disable any reagent.

  For this reason, it was not possible to cancel the measurement with the corresponding reagent for the patient sample that had been thrown in. In general, the reagents used for measurement are automatically determined by the device based on the expiration date, date and time of registration, remaining amount, etc., so measurement should not be performed with the relevant reagent. It was necessary to interrupt and remove the reagent. In particular, in calibration measurement, if a reagent in use becomes unusable due to a calibration failure, the calibration measurement of that reagent is normal again even though another spare reagent has been registered and it can be measured. Until then, patient samples could not be measured.

  For this reason, the user is forced to continue the analysis using the reagent that is known to be abnormal, or the measurement of the patient sample is interrupted until the calibration measurement is successful again. There was a great influence on the inspection work that required quickness, such as wasting and delaying the report of measurement results to the doctor.

  In recent years, due to stricter standards and laws and increased awareness of the guarantee of measurement results, each reagent bottle used for measurement is subjected to quality control measurement before and after use for patient sample measurement. A technique for assuring the measurement result of a patient sample measured with a reagent bottle is used.

  With regard to quality control samples before being used for patient sample measurement, it can be easily performed by performing quality control sample measurements when the user installs a reagent bottle, but for measurements after being used for patient sample measurement, In recent years, in order to realize continuous measurement, when a plurality of reagent bottles of the same type are installed, there is a function of detecting that the remaining amount has run out and automatically switching the reagent bottle to be used according to the order of use. Therefore, it is necessary for a laboratory technician to quickly measure a large number of patient samples with a device equipped with several tens to several hundreds of reagents, because the user must predict that the remaining amount will run out and interrupt quality control measurement. Thus, it was very difficult to perform quality control measurement.

  Therefore, the object of the present invention is to arbitrarily select a case where the user finds an abnormality presumed to be caused by the reagent used for the measurement from the result of the measurement of the patient sample or the quality control sample and the calibration measurement or the reaction process data. The system is equipped with a means to disable the use of reagents and a means for the equipment to automatically secure the remaining amount of reagents necessary for quality control sample measurement, enabling automatic cancellation of analysis using reagents that are known to be abnormal By providing an analysis device, it is intended to prevent loss of valuable patient samples, improve analysis efficiency, and realize reliable accuracy control.

  The above and other objects and novel features of the present invention will be apparent from the description of this specification and the accompanying drawings.

  Of the inventions disclosed in the present application, the outline of typical ones will be briefly described as follows.

  That is, the outline of a typical one includes an analysis unit that analyzes a sample, a display unit that displays information related to sample analysis, and a control unit that controls the analysis unit and performs sample analysis processing. Displays a screen showing information on the reagent used in the analysis of the sample on the display unit, receives the mask instruction of the reagent operated based on the display screen, and inputs the reagent based on the input mask instruction of the reagent. The mask is designated, and the mask designated reagent is not used in the analysis of the sample.

  The effects obtained by typical ones of the inventions disclosed in the present application will be briefly described as follows.

  In other words, the effect obtained by a representative one is that the user finds an abnormality that is presumed to be caused by the reagent used for the measurement from the measurement result of the patient sample or the quality control sample, the result of the calibration measurement, or the reaction process data. In addition, the reagent can be set to be unusable, analysis using a reagent known to be abnormal can be canceled immediately, and measurement can be performed using another spare reagent (standby reagent). Thus, it is possible to prevent valuable patient samples from being wasted, and delays in reporting the measurement results to the doctor due to the interruption of analysis and the time required for calibration remeasurement.

  In addition, the device automatically secures the remaining amount of reagent necessary for quality control sample measurement after being used for patient sample measurement, so that the user can predict that there will be no remaining amount for quality control sample measurement. In addition, there is no need to interrupt the analysis, and the burden on the user can be reduced and the analysis efficiency can be improved.

1 is a system configuration diagram showing a system configuration of an automatic analyzer according to an embodiment of the present invention. It is explanatory drawing for demonstrating the reagent mask function of the automatic analyzer which concerns on one embodiment of this invention. It is explanatory drawing for demonstrating the reagent mask function by the reagent mask condition setting of the automatic analyzer which concerns on one embodiment of this invention. It is a flowchart which shows the reagent mask process of the automatic analyzer which concerns on one embodiment of this invention. It is a flowchart which shows the reagent mask process of the automatic analyzer which concerns on one embodiment of this invention. It is explanatory drawing for demonstrating the reagent mask cancellation | release function of the automatic analyzer which concerns on one embodiment of this invention. It is a flowchart which shows the reagent mask cancellation | release process of the automatic analyzer which concerns on one embodiment of this invention. It is explanatory drawing for demonstrating the reagent mask by the reagent status screen of the automatic analyzer which concerns on one embodiment of this invention.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. Note that components having the same function are denoted by the same reference symbols throughout the drawings for describing the embodiment, and the repetitive description thereof will be omitted.

<System configuration of automatic analyzer>
With reference to FIG. 1, the configuration of an automatic analyzer according to an embodiment of the present invention will be described. FIG. 1 is a system configuration diagram showing a system configuration of an automatic analyzer according to an embodiment of the present invention.

  In FIG. 1, an automatic analyzer includes a sample input unit 204 for inputting a sample 202, a plurality of analysis units 206 for analyzing the sample 202, a sample storage unit 209 for storing the sample 202 after analysis, and a plurality of analyzes for the sample 202. A transport line 205 for transporting to the unit 206 is provided.

  The analysis unit 206 includes a reagent disk 208 that stores a plurality of reagents 207 used for performing analysis.

  The sample input unit 204, the analysis unit 206, and the sample storage unit 209 are connected to the operation unit PC211 serving as the display unit and the control unit of the automatic analyzer via the hub 210 via network cables. It is connected to the host system 212 via a network. The operation unit PC is also connected to the remote system 213 through a public line.

<Operation of automatic analyzer during analysis>
Next, the operation | movement at the time of the analysis by the automatic analyzer which concerns on one embodiment of this invention is demonstrated.

  In the analysis by the automatic analyzer, first, the user 201 mounts a sample 202 as a target in calibration measurement, quality control sample measurement, and patient sample measurement on a sample rack 203 on which a plurality of samples can be mounted. The sample rack 203 on which the sample is loaded is installed in the sample loading unit 204, and the installed sample rack 203 is sequentially loaded into the transfer line 205 and transferred to a single or a plurality of analysis units 206 that perform analysis on the sample 202. The analysis unit 206 recognizes the sample rack 203 and the sample 202 and performs analysis necessary for the sample 202.

  The reagent 207 necessary for the analysis is set on the reagent disk 208 by the user 201 prior to the analysis. For the measurement item, a plurality of reagents 207 can be installed so that they can be used by switching (changeover) in case the remaining amount is insufficient or the reagent is abnormal. The sample rack 203 subjected to the necessary analysis is transported to the sample storage unit 209.

  Further, the user 201 makes an analysis request (measurement request) for each sample 202 from the host system 212 or the operation unit PC 211, and the sample 202 to be analyzed is mounted on the sample rack 203 and installed in the sample input unit 204. The information requested for analysis is transmitted to the analysis unit 206 via the network, and the results and reaction process data analyzed by the analysis unit 206 are transmitted to the operation unit PC 211 and the host system 212.

  The operation unit PC 211 is connected to the remote system 213 via a public line. The remote system 213 stores information such as analysis parameters, which are analysis condition information using the reagent 207 used in the automatic analyzer, and distributes analysis parameters in response to a request from the operation unit PC 211.

  The distributed analysis parameters are stored in the operation unit PC 211 and transmitted to the analysis unit when the sample 202 is analyzed.

<Reagent mask function>
First, an outline of the reagent mask function in the present embodiment will be described.

  In the present embodiment, the reagent mask function is realized by providing the operation unit PC 211 with a screen interface and the analysis unit 206 with analysis control scheduling, and this configuration is the best mode from the viewpoint of system configuration and operability. It is.

  First, the user confirms the measurement result and reaction process data received from the analysis unit 206 on the screen of the operation unit PC 211, and if an abnormality that is supposed to be caused by the reagent 207 used for the measurement is found, the reagent mask is displayed from the screen. Instruct.

  Further, according to the reagent mask instruction from the screen, the operation unit PC 211 and the analysis unit 206 perform analysis control scheduling so that the relevant reagent 207 stored in the reagent disk 208 is not used in the subsequent measurement.

  Also, a reagent mask instruction means is provided on the host system 212 or remote system 213 according to the usage form of the user 201, and the contents of the instructions are transmitted to the operation unit PC 211 and the analysis unit 206 via the network to realize a reagent mask function. You may do it.

  Next, details of the reagent mask function of the automatic analyzer according to the embodiment of the present invention will be described with reference to FIG. FIG. 2 is an explanatory diagram for explaining the reagent mask function of the automatic analyzer according to the embodiment of the present invention, and shows an example of a reaction process data screen having the reagent mask function.

  First, the user 201 confirms the reaction process data that is output from the automatic analyzer and displayed on the screen of the operation unit PC 211 and displays the measurement results and the reaction absorbance data of the measurement process in time series.

  The user 201 confirms the reaction process data screen 101 as shown in FIG. 2 in order to obtain more detailed information when an abnormality sign is seen in the measurement result. In particular, since abnormalities other than the measurement points used for calculating the measurement results do not appear in the measurement results, the reaction process data screen 101 having information on all the photometry points is referred to very often when checking the results. The

  For this reason, it is best in terms of operability to provide a reaction process data screen as shown in FIG. 2 with a reagent mask function used when confirming an abnormality presumed to be caused by the reagent 207 used in the measurement. is there. The reaction process data screen 101 is a screen for displaying absorbance data measured in the measurement process in time series.

  In FIG. 2, the sample number 102 displays the number of the sample measured by calibration measurement, quality control sample measurement, and patient sample measurement. The measurement item 103 displays the measured measurement item name. The reagent position 104 displays the installation position of the reagent used in the measurement.

  The reaction process data 105 is graphed with absorbance data measured in the measurement process as absorbance on the vertical axis and photometric points on the horizontal axis.

  When the user 201 confirms the reaction process data and confirms an abnormality presumed to be caused by the reagent 207 used for the measurement, the user 201 depresses the reagent mask button 106 to display the reagent indicated in the reagent position 104 used for the measurement. Mask the reagent so that it is not used for subsequent measurements. The reagent mask button 106 can be pressed even when the automatic analyzer is measuring so that the relevant reagent can be masked immediately.

  The reagent changeover permission check box 107 indicates whether or not to permit measurement using another reagent when masking a reagent when a plurality of reagents are registered in the apparatus for the measurement item. specify. When the reagent changeover permission check box 107 is on, the measurement is continued using another reagent, and when the reagent changeover permission check box 107 is off, the subsequent measurement for the measurement item is canceled. The reagent mask comment 108 is an area where the user inputs the reason why the reagent mask is used.

  In the present embodiment, by providing such a function, when the user confirms an abnormality without interrupting the analysis work, the subsequent measurement using the reagent is immediately canceled, and valuable patient samples and Consumables can be prevented from being wasted.

  Moreover, even if a reagent mask is used, another reagent can be used and measurement can be continued, and delay of measurement result reporting can be prevented.

  In addition, although the example which provided the reagent mask function in the reaction process data screen 101 as shown in FIG. 2 was described here, the measurement result screen for displaying the measurement result and the reagents installed in the automatic analyzer are summarized. By providing a similar reagent mask function on the displayed reagent screen or the like, further improvement in user operability can be expected.

<Reagent mask function by setting reagent mask conditions>
Next, referring to FIG. 3, the reagent mask function by the reagent mask condition setting of the automatic analyzer according to the embodiment of the present invention will be described. FIG. 3 is an explanatory diagram for explaining the reagent mask function by the reagent mask condition setting of the automatic analyzer according to the embodiment of the present invention, and shows an example of the reagent mask condition setting screen.

  In addition to the reagent mask specified by the user 201 on the reaction process data screen 101 shown in FIG. 2, the abnormality estimated to be caused by the reagent 207 used for the measurement is displayed on the reagent mask condition setting screen 301 shown in FIG. The automatic analyzer automatically determines the reagent mask.

  By setting the reagent mask conditions in the automatic analyzer in advance, the automatic analyzer can automatically mask the reagent when the conditions are met. In addition, by setting the amount of reagent necessary for measuring a quality control sample in advance, the automatic analyzer automatically detects the relevant reagent when the remaining amount of the reagent reaches the set amount during patient sample measurement. By reagent masking, a reagent for quality control sample measurement after patient sample measurement can be ensured reliably and easily.

  A reagent mask condition setting screen 301 shown in FIG. 3 is a screen for setting conditions for the automatic analyzer to automatically mask the reagent.

  The calibration failure check box 302 is a setting for whether to mask the reagent used for calibration measurement when the measurement result becomes abnormal in the calibration measurement. The normal value range 304 for the quality control average value sets the range of the normal value of the quality control sample measurement result. The range of normal values is specified by the standard deviation (± 1 to 3 SD) with respect to the average value of quality control. If the measurement result of the quality control sample is out of this setting range, it is judged as abnormal and the relevant reagent is masked. The normal value range check box 303 for the accuracy management average value is a setting as to whether or not to validate the condition of the normal value range 304 for the accuracy management average value.

  The number of consecutive occurrences of the same data alarm between different samples 306 is set as the number of times the same data alarm is continuously added to the measurement results of a plurality of quality control samples as a condition for reagent masking. The number of consecutive occurrences of the same data alarm between different samples check box 305 is a setting as to whether or not to enable the condition of the number of consecutive occurrences of the same data alarm between different samples 306.

  The number of consecutive data alarm occurrences 308 between different samples is set as the number of times any one of the data alarms is continuously added to the measurement results of a plurality of quality control samples as a condition for reagent masking. A different-sample data alarm continuous occurrence count check box 307 is a setting as to whether or not the condition of the different-sample data alarm consecutive occurrence count 308 is valid.

  When the same or some kind of data alarm occurs in succession to a plurality of quality control sample measurement results using the same reagent 207, such a setting is effective because the possibility of a problem due to the reagent 207 is very high. .

  In addition, regarding patient sample measurement, if the same or some data alarm occurs continuously in multiple patient sample measurement results using the same reagent, there is a very high possibility of a problem caused by the reagent. As in the case of the quality control sample measurement, the same data alarm continuous occurrence count between different samples check box 309, the same data alarm consecutive occurrence count between different samples 310, the data alarm consecutive occurrence count check box 311 between different samples, A setting is made for the number 312 of consecutive occurrences of data alarms between different samples.

  The reagent changeover permission check box 313 uses a different reagent when masking a reagent that matches the above-mentioned abnormal measurement result reagent mask condition when a plurality of reagents are registered in the apparatus for the measurement item. Specify whether or not to allow measurement. When the reagent changeover permission check box 313 is on, the measurement is continued using another reagent, and when it is off, the subsequent measurement for the measurement item is canceled.

  By providing such a function, by setting the conditions in the automatic analyzer in advance, the reagent can be automatically masked when the automatic analyzer matches the conditions. The measurement using the estimated reagent can be canceled and valuable patient samples and consumables can be prevented from being wasted. Further, even if a reagent mask is used, another reagent 207 can be used and measurement can be continued, and delay of measurement result reporting can be prevented.

  In addition, the accuracy control sample measurement necessary test number 315 sets the amount of reagent necessary for the accuracy control sample measurement after the patient sample measurement of each reagent. Depending on the user, the quality control sample measurement is performed a plurality of times in order to improve the quality control quality, and thus a variable setting is preferable. The accuracy control sample measurement necessary test number check box 314 is a setting as to whether or not the condition of the accuracy control sample measurement necessary test number 315 is valid.

  The reagent changeover permission check box 316 indicates that when a plurality of reagents are registered in the apparatus for the measurement item, another reagent is selected when the reagent mask is matched with the above-described quality control sample measurement reagent mask conditions. Specify whether to allow to use and measure. When the reagent changeover permission check box 316 is on, the measurement is continued using another reagent, and when it is off, the subsequent measurement for the measurement item is canceled. A setting button 317 is a button for setting and storing the conditions input on the reagent mask condition setting screen.

  By providing such a function, when the remaining amount of the reagent reaches the set amount during the measurement of the patient sample, the device automatically masks the relevant reagent as a reagent mask so that the quality control sample measurement after the patient sample measurement can be performed. Therefore, it is not necessary to predict that the user 201 runs out of the remaining amount for the quality control sample measurement, and it is not necessary to interrupt the analysis, thereby reducing the burden on the user 201 and improving the analysis efficiency. Can be planned.

<Reagent mask treatment>
Next, referring to FIGS. 4 and 5, the reagent mask process of the automatic analyzer according to the embodiment of the present invention will be described. 4 and 5 are flowcharts showing the reagent mask process of the automatic analyzer according to the embodiment of the present invention. FIG. 4 is a reagent mask process when the measurement result is abnormal focusing on a single measurement item. Indicates a reagent mask process for quality control sample measurement focusing on a single measurement item.

  First, the case of the reagent mask instruction by the user described in FIG. 2 will be described.

  As shown in FIG. 4, in step 401, the automatic analyzer performs calibration measurement, quality control sample measurement, or patient sample measurement. In step 402, the user 201 confirms the measurement result and reaction process data measured in step 401.

  When the user 201 confirms an abnormality presumed to be caused by the reagent used for the measurement, the user 201 instructs the reagent mask in step 403. If no reagent mask is specified in step 403, it is determined in step 404 whether or not a measurement request remains. If it remains in step 404, the measurement is continued in step 410 and does not remain in step 404. In this case, the measurement ends at step 412.

  If a reagent mask is instructed in step 403, a reagent mask is set in step 405 so that the corresponding reagent 207 is not used in subsequent measurements. In step 406, it is determined whether or not a measurement request remains. If no measurement request remains in step 406, the measurement ends in step 412.

  If the measurement request remains in step 406, the reagent changeover permission setting at the time of the reagent mask is determined in step 407. If not possible in step 407, the measurement is canceled in step 411 and the measurement ends in step 412. It becomes. If it is determined in step 407 that the reagent changeover permission can be set, it is determined in step 408 whether a reagent that can be changed over is registered in the apparatus. If it is not registered in step 408, the measurement is performed in step 411. Is canceled and the measurement ends in step 412.

  If registered in step 408, the measurement is rescheduled in step 409 using the changeover reagent. In step 410, measurement is performed based on the contents rescheduled in step 409. Thereafter, step 402 to step 410 are repeated until the measurement is completed.

  Next, an automatic reagent mask case by the automatic analyzer described with reference to FIG. 3 will be described.

  Basically, the flow chart of the process is the same as that in the case of the reagent mask instruction by the user 201 described above. In this case, the process in step 402 and step 403 in FIG. 4 is replaced with step 413 and step 414. it can.

  First, in step 401, the automatic analyzer performs calibration measurement, quality control sample measurement, or patient sample measurement.

  In step 413, it is checked whether or not the result measured in step 401 matches the reagent mask condition set on the reagent mask condition setting screen 301 shown in FIG. In step 414, if the result collated in step 413 does not match, the process proceeds to step 404. If the result collated in step 413 matches, the process proceeds to step 405 to set the reagent mask conditions in advance. By doing so, an automatic reagent mask can be realized.

  In addition, an apparatus having both the reagent mask instruction function by the user 201 and the automatic reagent mask function by the automatic analyzer is provided by performing the processes of Step 402, Step 403, Step 413, and Step 414 in parallel. can do.

  Next, as a processing of a reagent mask for quality control sample measurement focusing on a single measurement item, the automatic analyzer performs patient sample measurement in step 501 as shown in FIG. In step 502, the reagent remaining amount after the measurement is checked.

  In step 503, the remaining amount of the reagent is compared with the number of required accuracy control sample measurement tests set by the user 201 on the reagent mask condition setting screen 301 shown in FIG. As a result of the comparison in step 503, if the remaining amount of reagent is larger, it is determined in step 504 whether or not a measurement request remains, and if a measurement request remains in step 504, the measurement is continued in step 510. . If no measurement request remains in step 504, the measurement ends in step 512.

  In step 503, if the remaining amount of the reagent is less than or equal to the number of required accuracy control sample measurement tests, a reagent mask is set in step 505 so that the corresponding reagent is not used in the subsequent measurement. Then, in step 506, it is determined whether or not a measurement request remains. If no measurement request remains in step 506, the measurement ends in step 512.

  If the measurement request remains in step 506, the reagent changeover permission setting at the time of the reagent mask is determined in step 507. If not possible in step 507, the measurement is canceled in step 511 and the measurement ends in step 512. It becomes.

  If it is determined in step 507 that the reagent changeover permission can be set, it is determined in step 508 whether or not the reagent 207 that can be changed over is registered in the apparatus. If it is not registered in step 508, step 511 is performed. In step 512, the measurement is terminated.

  If registered in step 508, the measurement is rescheduled in step 509 using the changeover reagent. In step 510, measurement is performed based on the contents rescheduled in step 509.

  Thereafter, steps 502 to 510 are repeated until the measurement is completed. In step 512, the measurement is completed, and the user performs the quality control sample measurement after the patient sample measurement with the remaining reagent 207.

<Reagent mask release function>
Next, the reagent mask release function of the automatic analyzer according to the embodiment of the present invention will be described with reference to FIG. FIG. 6 is an explanatory diagram for explaining the reagent mask release function of the automatic analyzer according to the embodiment of the present invention, and shows an example of the reagent mask release screen.

  In FIG. 6, the reagent mask release screen 601 displays the reagent mask factor for the reagent 207 that has become a reagent mask by the reagent mask instruction function by the user or the automatic reagent mask function by the automatic analyzer, This is a screen for canceling the reagent mask when 207 becomes reusable. In the reagent mask release screen 601, the order of use can be specified when the mask of the reagent 207 is released.

  The measurement item pull-down 602 displays a measurement item name and can select a measurement item registered in the automatic analyzer. The reagent information display list 603 displays a list of reagent information registered in the apparatus for the measurement item selected by the measurement item pull-down 602. In this example, the order of use, the installation position in the reagent disk, the production lot, the initial registration date, the expiration date, the number of remaining tests, and the mask factor are displayed.

  The reagent mask release screen 601 is intended to release the reagent mask and set the order of use. Therefore, information related to the reagent mask and various types of information used as conditions for the automatic analyzer to determine the order of use of the reagents 207 And the display in ascending order of use order as shown in FIG. 6 are the best mode for the user to easily understand when setting the use order.

  The reagent 207 that has become the reagent mask displays the mask in the order of use and the factor that has become the reagent mask is displayed in the mask factor. When the masked reagent row is selected in the reagent information display list 603, the date and time when the reagent mask is set in the reagent mask date and time 604, and the reaction process data screen 101 shown in FIG. The comment entered by the user is displayed on the screen.

  Further, when the automatic analyzer sets the reagent mask in accordance with the reagent mask condition setting shown in FIG. 3, what conditions the automatic analyzer has in the mask factor and reagent mask comment 605 of the reagent information display list 603. The user 201 can understand the reason for the reagent mask by automatically displaying a message indicating whether the reagent mask has been matched.

  A mask release button 606 is a button for releasing the reagent mask of the reagent 207 selected in the reagent information display list 603. Use order change buttons 607 and 608 are buttons for moving the reagent row selected in the reagent information display list 603 up and down to change the use order.

  By providing such a function, the reagent masked reagent 207 can be returned to the measurement in the order intended by the user 201.

<Reagent mask release processing>
Next, referring to FIG. 7, the reagent mask releasing process of the automatic analyzer according to the embodiment of the present invention will be described. FIG. 7 is a flowchart showing the reagent mask release processing of the automatic analyzer according to the embodiment of the present invention, and shows the reagent mask release processing focusing on a single measurement item.

  First, in step 701, the user instructs to release the reagent mask and change the order of use from the reagent mask release screen 601 shown in FIG. In step 702, the mask that has been unmasked in step 701 is set to be unmasked so that it can be used in subsequent measurements. In step 703, the reagent use order is changed and set as specified in step 701.

  In step 704, it is determined whether or not a measurement request remains. If no measurement request remains in step 704, the measurement ends in step 709.

  If a measurement request remains in step 704, in step 705, according to the reagent use order set in step 702 and step 703, rescheduling is performed so that measurement is performed using the reagent in the highest priority order.

  In step 706, measurement is performed based on the contents rescheduled in step 705. In step 707, the remaining amount of the reagent is checked after the measurement. If there is no remaining reagent in step 707, the reagent is changed over to the next use order in step 708.

  If there is a remaining amount of reagent in step 707, the process returns to step 704, and thereafter, steps 704 to 708 are repeated until the measurement is completed.

<Reagent mask on the reagent status screen>
Next, referring to FIG. 8, a reagent mask on the reagent status screen of the automatic analyzer according to the embodiment of the present invention will be described. FIG. 8 is an explanatory diagram for explaining a reagent mask on the reagent status screen of the automatic analyzer according to the embodiment of the present invention.

  The above-described reagent mask condition setting screen 301 in FIG. 3 and the flowchart shown in FIG. 4 show an example in which the automatic analyzer automatically masks the reagent according to the measurement result by setting the conditions for masking the reagent 207 in advance. However, here, when there is an abnormality in calibration measurement, quality control sample measurement, patient sample measurement, it is displayed as reagent status information, and the user 201 performs calibration measurement and quality control sample measurement again, Alternatively, it is possible to specify whether the reagent 207 is masked.

  In FIG. 8, the reagent status screen 801 displays registration information of the reagent 207 and the status of an abnormality that has occurred in the measurement using the registered reagent 207. The user 201 confirms the display of the reagent status screen 801 and requests each reagent 207 to perform calibration measurement and quality control sample measurement as necessary.

  Also, when the reagent 207 is judged to be abnormal and is not used, or when it is not possible to secure time for performing calibration measurement and quality control sample measurement, and to continue patient sample measurement using another spare reagent for the time being Then, a reagent mask is set.

  The reagent information display list 802 displays a list of reagents 207 registered in the apparatus. The status display column 803 displays normality and abnormality of the results of calibration measurement, quality control sample measurement, and patient sample measurement using each reagent 207, and the cause is displayed in the case of abnormality.

  For example, in the example shown in FIG. 8, the reagent status AST 805 includes a character string “out of accuracy control range” in the status display column 803 because the result of the accuracy control sample measurement exceeds a preset accuracy control normal range. Is displayed. In addition, the reagent status CRP 806 reagent is abnormal in calibration measurement, and the calibration has failed, so the character string “Calib failure” is displayed in the status display column 803.

  In this example, normal and abnormal are displayed as character strings, but they may be distinguished by colors to be displayed. Further, the status display column 803 may be divided into three display columns for each of calibration measurement, quality control sample measurement, and patient sample measurement, and normality and abnormality in each measurement may be displayed. A calibration measurement request button 807 and a quality control sample measurement request button 808 are buttons for setting a request for calibration measurement and quality control sample measurement for the reagent 207 selected in the reagent information display list 802.

  A reagent mask button 809 is a button for setting a reagent mask for the reagent 207 selected in the reagent information display list 802. When the reagent mask button 809 is pressed, a reagent mask setting dialog 811 is displayed.

  In the reagent mask setting dialog 811, it is possible to select a measurement target to be reagent masked. The patient sample measurement mask radio button 812 is selected when only the patient sample measurement is performed as a reagent mask. The all measurement mask radio button 813 is selected when reagent measurement is performed for all measurements of calibration measurement, quality control sample measurement, and patient sample measurement. The reagent changeover permission check box 814 specifies whether or not to permit measurement using another reagent when masking a reagent when a plurality of reagents are registered in the apparatus for the measurement item. To do.

  When a reagent mask is set using the setting button 815, the measurement target of the set reagent mask is displayed in the reagent mask display column 804 as a character string “only patient sample” or “all”. The reagent mask release button 810 is a button for releasing the reagent mask set for the reagent selected in the reagent information display list 802.

  Although omitted in the example shown in FIG. 8, the comment input function at the time of the reagent mask shown in FIGS. 2 and 6 may be provided in the reagent mask setting dialog 811 and the display function may be provided in the reagent information display list 802. good.

  By enabling settings such as the patient sample measurement mask radio button 812 and the all measurement mask radio button 813, the options of the user 201 for the reagent abnormality are expanded, and only the patient sample measurement is performed according to the situation where the user 201 is placed. Then, it is possible to select whether calibration measurement and quality control sample measurement are performed again, or whether all the measurements are performed as reagent masks, and more flexible measures can be taken.

  The selection functions such as the patient sample measurement mask radio button 812 and the all measurement mask radio button 813 are the same as the reagent mask described in the reaction process data screen 101 shown in FIG. 2 and the reagent mask condition setting screen 301 shown in FIG. It can also be applied to settings.

  Although shown here as an example of the reagent status screen, similarly, a calibration screen for displaying and requesting calibration measurement for the reagent 207 registered in the automatic analyzer, and a recommended display and request for quality control measurement A similar function may be mounted on the quality control screen that performs the above.

  As mentioned above, the invention made by the present inventor has been specifically described based on the embodiment. However, the present invention is not limited to the embodiment, and various modifications can be made without departing from the scope of the invention. Needless to say.

  The present invention relates to an automatic analyzer for measuring a biological sample such as blood, urine, etc., for each reagent used, an apparatus that requires calibration of a measurement result by calibration measurement or accuracy management of a measurement result by quality control sample measurement, Widely applicable to the system.

  DESCRIPTION OF SYMBOLS 101 ... Reaction process data screen, 102 ... Sample number, 103 ... Measurement item, 104 ... Reagent position, 105 ... Reaction process data, 106 ... Reagent mask button, 107 ... Reagent changeover permission check box, 108 ... Reagent mask comment, 201 User, 202 ... Sample, 203 ... Sample rack, 204 ... Sample input unit, 205 ... Transport line, 206 ... Analyzing unit, 207 ... Reagent, 208 ... Reagent disc, 209 ... Sample storage unit, 210 ... Hub, 211 ... Operation Part PC, 212 ... Host system, 213 ... Remote system, 301 ... Reagent mask condition setting screen, 302 ... Calibration failure check box, 303 ... Normal value range check box, 304 ... Normal value range, 305 ... Same between different samples Data alarm continuous occurrence check box, 3 6 ... Number of consecutive occurrences of same data alarm between different samples, 307 ... Number of consecutive occurrences of data alarm between different samples, 308 ... Number of consecutive occurrences of data alarm between different samples, 309 ... Number of consecutive occurrences of same data alarm between different samples, check box, 310 ... Number of consecutive occurrences of same data alarm between different samples, 311 ... Number of consecutive occurrences of data alarm between different samples, 312 ... Number of consecutive occurrences of data alarm between different samples, 313 ... Reagent changeover permission check box, 314 ... Quality control sample Required test number check box, 315 ... Accuracy control sample measurement required test number, 316 ... Reagent changeover permission check box, 317 ... Setting button, 601 ... Reagent mask release screen, 602 ... Measurement item pull-down, 603 ... Reagent information display list 604 ... Medicine mask date / time, 605 ... Reagent mask comment, 606 ... Mask release button, 607 ... Use order change button, 801 ... Reagent status screen, 802 ... Reagent information display list, 803 ... Status display column, 804 ... Reagent mask display column, 807 ... calibration measurement request button, 808 ... quality control sample measurement request button, 809 ... reagent mask button, 810 ... reagent mask release button, 811 ... reagent mask setting dialog, 812 ... patient sample measurement mask radio button, 813 ... all measurement masks Radio button, 814 ... Reagent changeover permission check box, 815 ... Setting button.

Claims (10)

An analysis unit for analyzing the sample;
A display unit for displaying information on analysis of the sample;
A control unit that controls the analysis unit and performs analysis processing of the sample;
The control unit causes the display unit to display a screen showing information on the reagent used in the analysis of the sample, and inputs the mask instruction of the reagent operated based on the display screen. An automatic analyzer characterized in that the reagent is designated as a mask based on the mask instruction, and the reagent designated as a mask is not used in the analysis of the sample. The automatic analyzer according to claim 1,
The reagent mask instruction is input based on a mask instruction operation on a display screen of reaction process data in analysis of the sample when the reagent displayed on the display unit is used. Analysis equipment. The automatic analyzer according to claim 1,
The control unit stores information on reagent mask conditions for masking the reagent in advance, collates the measurement result obtained by analyzing the sample with the reagent mask conditions, and performs analysis when the reagent mask conditions are met. An automatic analyzer characterized in that the used reagent is designated as a mask. The automatic analyzer according to claim 1,
The controller stores in advance information on the reagent remaining amount of the reagent that is necessary for performing the quality control sample measurement at the time of the analysis, and the reagent becomes less than the reagent remaining amount during the analysis of the sample. In this case, an automatic analyzer is characterized in that the reagent is designated as a mask. The automatic analyzer according to claim 1,
The control unit displays a screen showing a list of measurement results using the reagent on the display unit, and inputs a mask instruction of the reagent operated based on information on the presence or absence of abnormality on the display screen. An automatic analyzer that designates a mask of the reagent based on the designated mask instruction of the reagent. The automatic analyzer according to any one of claims 1 to 5,
The control unit displays on the display unit a screen for selecting either a patient sample measurement or all measurements as a measurement target for masking the reagent, and a selection instruction operated based on the display screen. An automatic analyzer characterized by an input, and the mask designation of the reagent is performed based on the inputted selection instruction and the mask instruction. In the automatic analyzer of any one of Claims 1-6,
The automatic analysis apparatus, wherein the control unit continues the analysis with a reagent excluding the reagent designated by the mask when a plurality of the reagents are installed. In the automatic analyzer of any one of Claims 1-6,
The control unit causes the display unit to display a screen showing information on the reagent used in the analysis of the sample, and inputs the mask release instruction of the reagent operated based on the display screen. An automatic analyzer that unmasks the reagent designated for masking based on a mask removal instruction and uses the unmasked reagent for analysis. The automatic analyzer according to claim 8,
The control unit receives the designation of use priority operated together with the mask release instruction as input, and uses the reagents for analysis in the order of use priority based on the inputted designation of use priority. Automatic analyzer. In the automatic analyzer of any one of Claims 1-6,
The control unit is connected to a host system that stores information related to the reagent and the measurement result, and the mask instruction for the reagent is input based on an operation on the host system. apparatus.