JP2012239480A - Biological state estimation device and computer program - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a technique for further accurately acquiring the state of a person.SOLUTION: A frequency time-series waveform is acquired from a time-series waveform of biological signal, and a time-series waveform of frequency slope is further acquired. The time-series waveform of frequency slope is subjected to frequency analysis so as to acquire the number of break points that show a bifurcation phenomenon in each regression line on the basis of difference in the values of power spectral densities and difference in slopes of the regression lines, and a shape score based on the number of break points is acquired. A determination reference point is acquired using at least one of a regional score and the shape score of each regression line, and the state of a person is determined on the basis of the time-series change of the determination reference points. By acquiring scores, this configuration enables to determine the state of a person accurately and objectively.

Description

  The present invention relates to a technique for collecting a biological signal and estimating a biological state from a relative change from a predetermined state.

  In recent years, monitoring the biological state of a driver during driving has attracted attention as an accident prevention measure or the like. In Patent Documents 1 to 3, the present applicant discloses a method of determining a sleep onset symptom by arranging a pressure sensor in a seat cushion portion, collecting and analyzing a heel pulse wave.

  Specifically, the maximum value and the minimum value of the time series waveform of the pulse wave are obtained by the smoothing differential method using Savitzky and Golay, respectively. Then, the maximum value and the minimum value are divided every 5 seconds, and the average value of each is obtained. The square of the difference between the average values of the obtained local maximum and local minimum is used as a power value, and this power value is plotted every 5 seconds to create a time series waveform of the power value. In order to read the global change of the power value from this time series waveform, the gradient of the power value is obtained by the least square method for a certain time window Tw (180 seconds). Next, the next time window Tw is similarly calculated at the overlap time Tl (162 seconds), and the result is plotted. This calculation (movement calculation) is sequentially repeated to obtain a time series waveform of the gradient of the power value. On the other hand, the maximum Lyapunov exponent is obtained by chaos analysis of the time series waveform of the pulse wave, the maximum value is obtained by smoothing differentiation, and the time series waveform of the gradient of the maximum Lyapunov exponent is obtained by moving calculation.

  The time series waveform of the power value slope and the time series waveform of the maximum Lyapunov exponent slope are in opposite phase, and furthermore, the time series waveform of the power value slope has a low frequency and large amplitude waveform. The waveform is determined as a characteristic signal indicating a sleep onset sign, and the point at which the amplitude subsequently decreases is determined as the sleep onset point.

  Further, as Patent Document 4, an air bag (air pack) in which a three-dimensional solid knitted fabric is inserted is provided, and the air pack is disposed at a portion corresponding to a person's back to measure air pressure fluctuations of the air pack. A system for detecting a human biological signal from the obtained time-series data of air pressure fluctuation and analyzing the state of the human biological body is disclosed. Non-Patent Documents 1 and 2 also report attempts to detect a human biological signal by arranging an air pack sensor along the lumbar gluteal muscle. This air pressure fluctuation of the air pack is due to shaking of the descending aorta accompanying the movement of the heart, and it is possible to capture a state change closer to the movement of the heart than when using the buttocks pulse wave of Patent Documents 1 and 2. .

JP 2004-344612 A JP 2004-344613 A WO2005 / 092193A1 publication JP 2007-90032 A

“Original, Development of a method for measuring the symptoms of falling asleep using fingertip plethysmogram information” Yasunori Fujita (8 others), Ergonomics Vol 41, No. 1 4 (’05) "Application of biological fluctuation signals measured by non-invasive sensors to fatigue and sleep prediction", Naoki Ochiai (6 others), 39th Annual Meeting of the Japan Ergonomics Society, Chugoku-Shikoku Branch, 2006 Issued on May 25, Publisher: Japan Ergonomics Society Chugoku-Shikoku Branch Office "Prototype of vehicle seat with non-invasive biological signal sensing function", Shinichiro Maeda (4 others), 39th Japan Ergonomics Society China-Shikoku Branch Conference, Proceedings, November 25, 2006 Place: Japan Ergonomics Society Chugoku / Shikoku Branch Office

  As described above, in the techniques of Patent Documents 1 to 4 and Non-Patent Documents 1 to 3, the time-series waveform of the power value gradient and the time-series waveform of the gradient of the maximum Lyapunov exponent are in opposite phases, and the power value gradient When the low-frequency and large-amplitude waveforms occur in the time-series waveform, it is regarded as a sleep onset symptom phenomenon.

  The present applicant has also proposed the following technique as Japanese Patent Application No. 2009-237802. In other words, it is a technique that obtains a time series waveform of a frequency from a time series waveform of a biological signal obtained by a biological signal measuring means, and uses a frequency gradient time series waveform and a frequency variation time series waveform obtained from the time series waveform of this frequency. , Positive / negative of frequency slope time series waveform, positive / negative of integral waveform of frequency slope time series waveform, appearance of reverse phase when frequency slope time series waveform and frequency fluctuation time series waveform are output overlaid (appearance of reverse phase falling asleep) This is a technique for determining a person's condition by combining the signs).

  Although the present applicant has proposed a technique for grasping a person's state using a biological signal as described above, a proposal for a technique for grasping a person's state more accurately is always desired. Further, if there are a plurality of methods for grasping the state of the person, it becomes possible to grasp the state of the person more accurately by using them together. The present invention has been made in view of the above, and an object of the present invention is to provide a technique for analyzing a biological signal using a new analysis method and grasping the state of a person.

  Here, human constancy is maintained by fluctuation, and the frequency band is assumed to be in the VLF region and the ULF region. On the other hand, in atrial fibrillation, which is one of heart diseases, the place where the characteristics of fluctuations of the heart and circulatory system are switched is said to be 0.0033 Hz. By capturing fluctuations around 0.0033 Hz, Information on sex maintenance can be obtained. Therefore, the present inventor first performs analysis on a long period region (low frequency band) centered on 0.0035 Hz in the vicinity of 0.0033 Hz (for convenience of calculation, 0.0035 Hz is used instead of 0.0033 Hz). Focused on. On the other hand, according to experiments by the present inventor, characteristic fluctuations that change depending on a person's state of adaptation to stress and a state of feeling comfortable or uncomfortable in a shorter period than in a long period are centered on 0.01 Hz. It is found that it appears in the medium period region (medium frequency band) and the short period region (high frequency band) centered on 0.0225 Hz, and by tracking changes in these fluctuation states, It was considered that the state of the living body (whole body state) can be estimated, and the present invention has been completed.

  That is, the biological state estimation device of the present invention is a biological state estimation device that estimates a biological state using a biological signal collected by the biological signal measuring unit, and a predetermined measurement time obtained by the biological signal measuring unit. A frequency calculation means for obtaining a time series waveform of a frequency from a time series waveform of the biological signal in the above, and a predetermined time set with a predetermined overlap time in the time series waveform of the frequency of the biological signal obtained by the frequency calculation means A frequency slope time series analysis calculating means for performing a movement calculation for obtaining the slope of the frequency for each time window, and outputting a time series change of the slope of the frequency obtained for each time window as a frequency slope time series waveform; and the frequency slope Frequency analysis of the frequency gradient time series waveform in the predetermined time range obtained from the time series analysis calculation means, the power spectrum density and frequency A frequency analysis unit that outputs an analysis waveform indicating a relationship for each predetermined time range; a regression line calculation unit that obtains a regression line for each predetermined period region for each analysis waveform output by the frequency analysis unit; and for each period region Each regression line determined in step (1) is assigned a region score based on its slope, and each regression line is based on a difference in power spectral density values between regression lines in the adjacent frequency domain and a difference in slope between regression lines. Determine the number of break points that indicate the branching phenomenon in the whole, give a shape score based on the number of break points, and use the at least one of the area score and the shape score to determine a decision reference point for each analysis waveform And the state of the living body is estimated based on the time series change of the determination reference point of each analysis waveform obtained by the determination reference point calculation means. Characterized by comprising a state estimator.

  The regression line calculation means preferably obtains the regression line by dividing the analysis waveform to be analyzed into a long period area, a medium period area, and a short period area. Preferably, the regression line calculation means obtains the center of gravity of the analysis waveform set in each of the long period area, the medium period area, and the short period area as the center of the regression line. The regression line calculation means obtains a regression line for each of the ULF region and the VLF region, with the center of the regression line as a boundary in the long period region, and obtains a regression line for the ULF region and a regression line for the VLF region. It is determined whether or not the product of each slope is equal to or less than a predetermined value. If the product is less than the predetermined value, the regression lines of the ULF region and the VLF region are adopted. It is preferable to employ the regression line in FIG.

  The determination reference point calculation means divides the slope of each regression line in each region into three as a substantially horizontal state, upward and downward as the region score, and the upward and downward cases with respect to the score in the substantially horizontal state as a reference It is preferable that the score be increased or decreased in the case of. It is preferable that the determination reference point calculation unit is configured to give a higher score as the shape score as the number of breakage points is smaller. The determination reference point calculation means calculates the number of break points between two regression lines in adjacent periodic regions and the difference between power spectral density values between two regression lines in adjacent periodic regions and between two regression lines in adjacent periodic regions. When the difference between the values of the power spectral density is within a predetermined range and the difference between the inclination angles of the two regression lines is equal to or larger than a predetermined angle, it is preferable that each be counted as a break point.

The state estimation means calculates the following equation between the determination reference points of the analysis waveform in the two time ranges before and after the comparison target: functional point = determination reference point in the later time range + (determination reference point in the later time range−previous time range) It is preferable that a function point obtained by (determination reference point) × n (where n is a correction coefficient) is obtained in a time series, and the state of the living body is estimated from the time series change of the function points. The frequency calculation means includes a zero cross detection means for obtaining a time series waveform of a frequency using a zero cross point in the time series waveform of the biological signal, and a frequency time series waveform using a peak point of the time series waveform of the biological signal. It is preferable that at least one of the required peak detection means is provided.
The state estimation means includes a first determination reference point obtained from a frequency time-series waveform using the zero-cross detection means, and a second determination reference point obtained from a frequency time-series waveform using the peak detection means. And the index based on the first determination reference point is on one axis, the index based on the second determination reference point is on the other axis, and the first determination reference point and the second determination reference point are It is preferable that the time-series change of coordinates obtained from the above is obtained to estimate the state of the living body.

  The state estimation means determines that the coordinate time-series change line connecting the coordinates is a change tendency approximating the inclination of 1 / f, determines that it is comfortable, and changes in the vertical direction. If it is determined, it is preferable that the configuration is determined as uncomfortable.

  The state estimation means includes an active / adaptive region for each quadrant of a coordinate system having an index based on the first determination reference point on one axis and an index based on the second determination reference point on the other axis. The coordinate time-series change line to be compared is divided into a plurality of coordinate time-series change lines obtained at different measurement times by dividing into an active / resistance region, a resistance / resistance region, and a resistance / adaptive region. It is preferable to have means for estimating the physical condition according to the overall movement direction.

The overall main moving direction of the coordinate time series change line is:
If it is between the active / adapted region and the tolerance / adapted region, it is estimated that the physical condition is good,
When it is between the active / resistance region and the tolerance / adaptation region, it is assumed to be a normal state,
It is preferable to adopt a configuration in which it is estimated that there is a risk of sudden change in physical condition when the region is between the resistance / resistance region and the active / adaptive region.
Furthermore, in the time-series waveform of the frequency using the peak detecting means, the movement calculation for obtaining the average value of the frequency for each predetermined time window set with the predetermined overlap time is performed, and the average value of the frequency obtained for each time window. Frequency variation calculation means for outputting the time series change as a frequency fluctuation time series waveform, and the state estimation means provides an index corresponding to the functional point obtained from the time series waveform of the frequency using the zero cross detection means. Coordinates obtained from the functional point and the amount of change on one axis and an index corresponding to the amount of change in the predetermined time width of the frequency variation time-series waveform obtained by the frequency variation calculating means on the other axis It is preferable to obtain a time-series change in order to estimate the state of the living body related to a sense.

  The computer program of the present invention is a computer program set in a biological state estimating device that estimates a biological state using a biological signal collected by the biological signal measuring unit, and is obtained by the biological signal measuring unit. A frequency calculation procedure for obtaining a time series waveform of a frequency from a time series waveform of a biological signal at a predetermined measurement time, and a time series waveform of the frequency of the biological signal obtained by the frequency calculation procedure, with a predetermined overlap time A frequency slope time series analysis calculation procedure for performing a movement calculation to obtain the slope of the frequency for each predetermined time window set, and outputting a time series change in the slope of the frequency obtained for each time window as a frequency slope time series waveform; , The frequency slope time series waveform in the predetermined time range obtained from the frequency slope time series analysis calculation procedure is the frequency solution. A frequency analysis procedure for outputting an analysis waveform indicating the relationship between power spectral density and frequency for each predetermined time range, and a regression for obtaining a regression line for each predetermined period region for each analysis waveform output by the frequency analysis procedure. The linear calculation procedure and each regression line obtained for each of the periodic areas are given a region score based on the slope, and the difference between the power spectral density values between the regression lines in the adjacent frequency domain and between the regression lines Based on the difference in slope, the number of break points indicating the bifurcation phenomenon in each regression line is obtained, a shape score based on the number of break points is given, and at least one of the area score and the shape score is used for each analysis waveform. Determination reference point calculation procedure for determining a determination reference point, and time system of determination reference points for each analysis waveform determined by the determination reference point calculation procedure Change based on the, characterized in that to perform the state estimation procedure for estimating the state of a living body to the computer.

  In the regression line calculation procedure, the regression line is preferably obtained by dividing the analysis waveform to be analyzed into a long period area, a medium period area, and a short period area. In the regression line calculation procedure, it is preferable that a center of gravity of the analysis waveform set in each of the long period area, the middle period area, and the short period area is obtained as the center of the regression line. In the regression line calculation procedure, in the long period region, the regression line is further divided into a ULF region and a VLF region with the center of the regression line as a boundary, and a regression line in the ULF region and a regression line in the VLF region are obtained. It is determined whether or not the product of each slope is equal to or less than a predetermined value. If the product is less than the predetermined value, the regression lines of the ULF region and the VLF region are adopted. It is preferable that the regression line is adopted.

  In the determination reference point calculation procedure, as the area score, the slope of each regression line in each area is divided into three, roughly horizontal state, upward and downward, and the upward and downward cases are based on the score of the substantially horizontal state. It is preferable that the score be increased or decreased in the case of.

  It is preferable that the determination reference point calculation procedure has a configuration in which, as the shape score, a higher score is given as the number of break points is smaller.

  In the determination reference point calculation procedure, the number of break points is calculated between two regression lines in adjacent periodic regions, and when the difference in the value of power spectral density is not less than a predetermined value, and between two regression lines in adjacent periodic regions. When the difference between the values of the power spectral density is within a predetermined range and the difference between the inclination angles of the two regression lines is equal to or greater than a predetermined angle, it is preferable that each be counted as a break point.

The state estimation procedure is performed between the determination reference points of the analysis waveform in the two time ranges before and after the comparison target:
Function point = Judgment reference point of the later time range + (Judgment reference point of the later time range-Judgment reference point of the previous time range) x n (where n is a correction coefficient)
It is preferable that the function point obtained by the above is obtained in time series, and the state of the living body is estimated from the time series change of the function point.

  The frequency calculation procedure includes a zero cross detection procedure for obtaining a time series waveform of a frequency using a zero cross point in a time series waveform of the biological signal, and a time series waveform of a frequency using a peak point of the time series waveform of the biological signal. It is preferable to provide at least one of the desired peak detection procedures.

The state estimation procedure includes a first determination reference point obtained from a frequency time-series waveform using the zero-cross detection procedure, and a second determination reference point obtained from a frequency time-series waveform using the peak detection procedure. And
An index based on the first determination reference point is taken on one axis, an index based on the second determination reference point is taken on the other axis,
It is preferable to estimate a time-series change in coordinates obtained from the first determination reference point and the second determination reference point and estimate the state of the living body.

  The state estimation procedure determines that the coordinate time-series change line connecting the coordinates is a change tendency approximating to a 1 / f slope, and determines that it is comfortable and changes vertically. It is preferable to determine that it is uncomfortable.

  The state estimation procedure includes an active / adaptive region in each quadrant of a coordinate system having an index based on the first determination reference point on one axis and an index based on the second determination reference point on the other axis. The coordinate time-series change line to be compared is divided into a plurality of coordinate time-series change lines obtained at different measurement times by dividing into an active / resistance region, a resistance / resistance region, and a resistance / adaptive region. It is preferable to estimate the physical condition based on the overall movement direction.

The overall main moving direction of the coordinate time series change line is:
If it is between the active / adapted region and the tolerance / adapted region, it is estimated that the physical condition is good,
When it is between the active / resistance region and the tolerance / adaptation region, it is assumed to be a normal state,
It is preferable to presume that there is a risk of sudden change in physical condition between the resistance / resistance region and the active / adaptive region.
Furthermore, in the time-series waveform of the frequency using the peak detection procedure, movement calculation is performed to obtain the average value of the frequency for each predetermined time window set with the predetermined overlap time, and the average value of the frequency obtained for each time window A frequency fluctuation calculation procedure for outputting a time series change as a frequency fluctuation time series waveform, wherein the state estimation procedure uses an index corresponding to the functional point obtained from the frequency time series waveform using the zero cross detection procedure. Coordinates obtained from the function point and the amount of change on one axis and an index corresponding to the amount of change in the predetermined time width of the frequency variation time-series waveform obtained by the frequency variation calculation procedure on the other axis It is preferable to obtain a time-series change in order to estimate the state of the living body related to a sense.

  The present invention has means for obtaining a time series waveform of a frequency from a time series waveform of a biological signal, and further obtaining a time series waveform of a frequency gradient to perform frequency analysis. By performing such a gradient time series analysis, a time series waveform consisting of components with a long period of 3 to 5 minutes is created, and the result of frequency analysis of the time series waveform for 24 hours while being short-time measurement data Data showing the same tendency as can be obtained. Then, the frequency analysis waveform is divided into predetermined period areas, preferably divided into a long period area, an intermediate period area, and a short period area, a regression line is obtained for them, and the result is scored using a predetermined criterion, By capturing these time-series changes, it is possible to estimate a state related to physical condition and sense. Note that the sense is a relative feeling when the state changes, and a feeling of comfort or discomfort is caused by the change of the state. Thus, for example, if the unpleasant state continues, the uncomfortable state will feel normal and the person has adapted to it. In order to capture these state changes, it is important to grasp the time series change of the frequency analysis waveform.

  In other words, by using a time-series waveform of inclination, the body surface pulse of the atrial, ventricular, and aortic swaying in the vicinity of 0.5 Hz, where characteristics do not appear unless long-time measurement is performed for about 24 hours, is performed. It can capture waves and is effective in estimating the state of the living body, and by capturing changes in the long-period region, it can capture changes related to the homeostasis maintenance function of the living body. By capturing the change in the short-period region, it is possible to estimate a change in stress and a pleasant / unpleasant state with respect to a change in the in vivo environment caused by a lesion or the like. In addition to the current state estimation, it is also possible to capture sudden changes in physical condition that may occur in the future. At this time, the above-described method of obtaining a regression line and scoring it is effective in recognizing these changes remarkably.

FIG. 1 is a diagram showing a biological signal measuring means used in one embodiment of the present invention. FIG. 2 is a diagram showing another aspect of the biological signal measuring means according to the embodiment. FIG. 3 is a diagram showing a process of incorporating the biological signal measuring means into the sheet. FIG. 4 is a diagram illustrating a configuration of the biological state estimation apparatus according to an embodiment of the present invention. FIG. 5 is a diagram for explaining a method for obtaining a time-series waveform by the zero-cross detecting unit and a method for obtaining a time-series waveform by the peak detecting unit from the output signal obtained from the biological signal measuring unit. FIGS. 6A to 6E are diagrams for explaining a method for creating a coordinate time-series change line created by the state estimating means. 7A to 7E are diagrams showing analysis waveforms and calculated functional points in Test Example 1. FIG. 8A to 8E are diagrams showing analysis waveforms and calculated functional points in Test Example 1. FIG. 9A to 9E are diagrams showing analysis waveforms and calculated functional points in Test Example 1. FIG. 10A to 10E are diagrams showing analysis waveforms and calculated functional points in Test Example 1. FIG. 11A to 11D are diagrams showing analysis waveforms and calculated functional points in Test Example 1. FIG. 12A to 12D are diagrams showing analysis waveforms and calculated functional points in Test Example 1. FIG. FIGS. 13A to 13H are diagrams showing analysis waveforms and calculated functional points in Test Example 1. FIG. 14A to 14H are diagrams showing analysis waveforms and calculated functional points in Test Example 1. FIG. 15A to 15B are graphs showing the degree of change in physical condition in Test Example 1. FIG. FIG. 16 is a diagram showing a coordinate time series change line based on the measurement result of Test Example 1. FIG. FIG. 17A is a diagram showing sensory evaluation of the subject in Test Example 1, and FIG. 17B is a diagram for explaining a whole body state determination method using a coordinate time-series change line. 18A to 18E are diagrams showing analysis waveforms and calculated functional points in Test Example 2. FIG. 19A to 19E are diagrams showing analysis waveforms and calculated functional points in Test Example 2. FIG. 20A to 20E are diagrams showing analysis waveforms and calculated functional points in Test Example 2. FIG. 21A to 21E are diagrams showing analysis waveforms and calculated functional points in Test Example 2. FIG. FIG. 22 is a graph showing the degree of physical condition change in Test Example 2. FIG. 23 is a diagram illustrating a coordinate time-series change line based on the measurement result of Test Example 2. FIG. 24 is a diagram showing sensory evaluation of the subject in Test Example 2. FIG. 25 is a diagram illustrating an analysis result by an electroencephalogram, a fingertip plethysmogram, and a heartbeat in the awakening induction posture of the subject in Test Example 2. FIG. 26 is a diagram illustrating an analysis result based on an electroencephalogram, a fingertip volume pulse wave, and a heartbeat in the relaxed posture of the subject in Test Example 2. FIGS. 27A to 27F are diagrams showing analysis waveforms and calculated functional points in Test Example 3. FIG. 28A to 28F are diagrams showing analysis waveforms and calculated functional points in Test Example 3. FIG. 29A to 29F are diagrams showing analysis waveforms and calculated functional points in Test Example 3. FIG. 30A to 30F are diagrams showing analysis waveforms and calculated functional points in Test Example 3. FIG. 31A to 31B are graphs showing the degree of physical condition change in Test Example 3. FIG. FIG. 32 is a diagram showing a coordinate time-series change line based on the measurement result of Test Example 3. FIG. 33 is a diagram showing sensory evaluation of the subject in Test Example 3. FIG. 34 is a diagram showing an analysis result based on an electroencephalogram, a fingertip volume pulse wave, and a heartbeat in the awakening induction posture of the subject in Test Example 3. FIG. 35 is a diagram showing an analysis result based on an electroencephalogram, a fingertip volume pulse wave, and a heartbeat in the relaxed posture of the subject in Test Example 3. 36 (a) to 36 (f) are diagrams showing analysis waveforms and calculated functional points in Test Example 4. FIG. 37 (a) to 37 (f) are diagrams showing analysis waveforms and calculated functional points in Test Example 4. FIG. 38A to 38F are diagrams showing analysis waveforms and calculated functional points in Test Example 4. 39A to 39F are diagrams showing analysis waveforms and calculated functional points in Test Example 4. FIG. 40 (a) to 40 (b) are graphs showing the degree of change in physical condition in Test Example 4. FIG. 41 is a diagram showing a coordinate time-series change line based on the measurement result of Test Example 4. FIG. 42 is a diagram showing sensory evaluation of the subject in Test Example 4. FIG. 43 is a diagram illustrating analysis results of the subject of Test Example 4 based on brain waves, fingertip volume pulse waves, and heartbeats. FIG. 44 is a diagram showing the head acceleration of the subject in Test Example 4. FIG. 45 is a diagram showing the head acceleration of the subject in Test Example 4, and is a continuation of FIG. FIG. 46 is a diagram showing the head acceleration of the subject in Test Example 4 and other indices together. 47A to 47F are diagrams showing analysis waveforms and calculated functional points in Test Example 5. FIG. 48A to 48F are diagrams showing analysis waveforms and calculated functional points in Test Example 5. FIG. 49A to 49F are diagrams showing analysis waveforms and calculated functional points in Test Example 5. FIG. 50 (a) to 50 (f) are diagrams showing analysis waveforms and calculated functional points in Test Example 5. FIG. 51A to 51B are graphs showing the degree of physical condition change in Test Example 5. FIG. 52 is a diagram showing a coordinate time-series change line based on the measurement result of Test Example 5. FIG. FIG. 53 is a diagram showing sensory evaluation of the subject in Test Example 5. FIG. 54 is a diagram showing an analysis result based on an electroencephalogram, a fingertip volume pulse wave, and a heartbeat in the awakening induction posture of the subject in Test Example 5. FIG. 55 is a diagram showing analysis results based on an electroencephalogram, a fingertip plethysmogram, and a heartbeat when the subject of Test Example 5 is in a relaxed posture. FIG. 56 is a diagram showing the distribution of functional points of each subject in Test Example 6. FIG. 57 is a diagram showing a distribution of average values and standard deviations of functional scores for each subject in Test Example 6. FIG. 58 is a diagram showing the ratio of subjects determined to be healthy, non-disease, and disease in Test Example 6. FIG. 59 is a diagram showing the proportions determined as healthy, non-disease, and illness according to physical condition based on self-report in Test Example 6. FIG. 60 is a diagram showing the ratio of the sudden change risk of the subject in Test Example 6. 61A to 61C are diagrams for explaining the determination method of Test Example 7. FIG. 62A to 62C are diagrams showing the determination results of Test Example 7. FIG. 63A to 63C are diagrams showing the determination results of Test Example 7. FIG. FIGS. 64A to 64C are diagrams showing the determination results of Test Example 7. FIG. 65A to 65C are diagrams showing the determination results of Test Example 7. FIG.

  Hereinafter, the present invention will be described in more detail based on the embodiments of the present invention shown in the drawings. 1 and 2 are body surface pulse waves, which are biological signals to be analyzed by the biological state estimating apparatus 60 according to the present embodiment, in this case, heart sway waves (atrium detected from the back of a human upper body). FIG. 3 is a diagram showing a biological signal measuring means 1 that collects a biological signal that is a body surface pulse wave accompanying the motion of the ventricle and the aorta and directly reflects the motion of the heart. It is the figure which showed the process in which this biosignal measuring means 1 is integrated in the seat 100 for motor vehicles. First, the biological signal measuring means 1 will be described. The biological signal measuring means 1 includes a three-dimensional solid knitted fabric 10, a three-dimensional solid knitted fabric support member 15, a film 16, plate-like foams 21 and 22, and a vibration sensor 30.

  For example, as disclosed in JP-A-2002-331603, the three-dimensional solid knitted fabric 10 includes a pair of ground knitted fabrics spaced apart from each other and a pair of ground knitted fabrics that reciprocate between the pair of ground knitted fabrics. The knitted fabric has a three-dimensional three-dimensional structure having a large number of connecting yarns for joining the two.

  One ground knitted fabric is formed by, for example, a flat knitted fabric structure (fine stitches) that is continuous in both the wale direction and the course direction from a yarn obtained by twisting a single fiber. For example, a knitted structure having a honeycomb-shaped (hexagonal) mesh is formed from a yarn obtained by twisting short fibers. Of course, this knitted fabric structure is arbitrary, and it is also possible to adopt a knitted fabric structure other than a fine structure or a honeycomb shape, and a combination thereof is also arbitrary, such as adopting a fine structure for both. The connecting yarn is knitted between two ground knitted fabrics so that one ground knitted fabric and the other ground knitted fabric maintain a predetermined distance. In this embodiment, since the solid vibration of the three-dimensional solid knitted fabric, in particular, the string vibration of the connecting yarn is detected, the connecting yarn is preferably composed of a monofilament. However, the resonance depends on the type of biological signal to be collected. In order to adjust the frequency, the connecting yarn can also be composed of multifilaments.

  Further, the three-dimensional solid knitted fabric 10 has a load-deflection characteristic in the thickness direction that is placed on a measurement plate and pressed with a pressure plate having a diameter of 30 mm or 98 mm in diameter within a range up to a load of 100 N. It is preferable to provide a spring constant approximating the load-deflection characteristics of the muscles of the buttocks. Specifically, the spring constant when pressed with a pressure plate with a diameter of 30 mm is in the range of 0.1 to 5 N / mm, or the spring constant when pressed with a pressure plate with a diameter of 98 mm is 1 to 10 N / mm. It is preferable to use one that is mm. By approximating the load-deflection characteristics of the muscles of the human buttocks, the three-dimensional knitted fabric balances with the muscles, and when biological signals such as heartbeat, breathing, atrial and aortic oscillations are propagated, the three-dimensional The three-dimensional knitted fabric generates vibration similar to that of human muscles, and can propagate a biological signal without greatly attenuating it.

  As such a three-dimensional solid knitted fabric, for example, the following can be used. Each three-dimensional solid knitted fabric can be used by stacking a plurality of pieces as necessary.

(1) Product number: 49076D (manufactured by Sumie Textile Co., Ltd.)
Material:
Front side ground knitted fabric: twisted yarn of 300 dtex / 288 f polyethylene terephthalate fiber false twisted yarn and 700 dtex / 192 f polyethylene terephthalate fiber false twisted yarn Back side ground knitted fabric: 450 dtex / 108 f polyethylene Combination of terephthalate fiber false twisted yarn and 350 decitex / 1f polytrimethylene terephthalate monofilament Linked yarn ... 350 decitex / 1f polytrimethylene terephthalate monofilament

(2) Product number: 49011D (manufactured by Sumie Textile Co., Ltd.)
Material:
Ground knitted fabric (warp) ... 600 dtex / 192f polyethylene terephthalate fiber false twisted yarn Ground knitted fabric (weft) ... 300 dtex / 72f polyethylene terephthalate fiber false twisted yarn Linked yarn ... ... 800 decitex / 1f polyethylene terephthalate monofilament

(3) Product number: 49013D (manufactured by Sumie Textile Co., Ltd.)
Material:
Front side ground knitted fabric: two twisted yarns of 450 dtex / 108f polyethylene terephthalate fiber false twisted yarn Back side ground knitted fabric ... 450 twists of polyethylene terephthalate fiber false twisted yarn of 108 dtex / 108f Connecting thread: 350 dtex / 1f polytrimethylene terephthalate monofilament

(4) Product number: 69030D (manufactured by Sumie Textile Co., Ltd.)
Material:
Front side ground knitted fabric: 2 twisted yarns of 450 dtex / 144 f polyethylene terephthalate fiber false twisted yarn Back side ground knitted fabric ... 450 dtex / 144 f polyethylene terephthalate fiber false twisted yarn and 350 dtex / 1 f Combined with polytrimethylene terephthalate monofilaments of linking yarns ... 350 dtex / 1f polytrimethylene terephthalate monofilaments

(5) Product number manufactured by Asahi Kasei Fibers Co., Ltd .: T24053AY5-1S

  The plate-like foams 21 and 22 are preferably composed of bead foams. As the bead foam, for example, a foam molded body by a bead method of a resin containing at least one of polystyrene, polypropylene, and polyethylene can be used. The plate-like foams 21 and 22 made of bead foam propagate biosignals with minute amplitudes as membrane vibrations due to the characteristics of spherical resin films formed by foaming that constitute individual fine beads. . This membrane vibration is transmitted to the three-dimensional solid knitted fabric as a string vibration, the membrane vibration and the string vibration are superimposed, and the biological signal is a vibration described later as a mechanical vibration amplified by the superposition of the membrane vibration and the string vibration. Detected by sensor 30. Therefore, detection of a biological signal becomes easy.

  When the plate-like foams 21 and 22 are formed of bead foams, the foaming ratio is preferably in the range of 25 to 50 times and the thickness is preferably less than the average diameter of the beads. For example, when the average diameter of 30 times expanded beads is about 4 to 6 mm, the thickness of the plate-like foams 21 and 22 is sliced to about 3 to 5 mm. As a result, soft elasticity is imparted to the plate-like foams 21 and 22, and solid vibration resonating with vibration having a small amplitude is easily generated. The plate-like foams 21 and 22 may be arranged on both sides of the three-dimensional solid knitted fabric 10 as in the present embodiment, but are arranged on either one side, preferably only on the seat back side. It can also be configured.

  Here, the three-dimensional solid knitted fabric 10 is a strip having a width of 40 to 100 mm and a length of 100 to 300 mm. With this size, preliminary compression (a state in which tension is generated in the connecting yarn) is likely to occur in the three-dimensional solid knitted fabric 10, and an equilibrium state is easily created between the person and the three-dimensional solid knitted fabric 10. In this embodiment, in order to reduce a sense of incongruity when a person comes into contact with the back, two sheets are arranged on the object with a portion corresponding to the spinal column in between. In order to easily arrange the three-dimensional solid knitted fabric 10 at a predetermined position, the three-dimensional solid knitted fabric 10 is preferably supported by a three-dimensional solid knitted fabric support member 15 as shown in FIG. The three-dimensional three-dimensional knitted fabric support member 15 is formed in a plate shape, and two vertically arranged through holes 15a and 15a are formed at symmetrical positions with a portion corresponding to the spine. The three-dimensional three-dimensional knitted fabric support member 15 is preferably composed of a bead foam formed in a plate shape, like the plate foams 21 and 22. When the three-dimensional three-dimensional knitted fabric support member 15 is composed of a bead foam, a preferable foaming ratio and thickness range are the same as those of the plate-like foams 21 and 22. However, in order to cause the membrane vibration more remarkably by the biological signal, the thickness of the plate-like foams 21 and 22 laminated on the upper and lower sides of the three-dimensional solid knitted fabrics 10 and 10 is set to It is preferable that the thickness is smaller than the thickness.

  In the state where the two three-dimensional solid knitted fabrics 10 and 10 are inserted and arranged in the placement through holes 15a and 15a formed in the three-dimensional solid knitted fabric support member 15, the film 16 on the front side and the back side of the three-dimensional solid knitted fabric 10 and 10 16 are stacked. In the present embodiment, the peripheral portions of the films 16 and 16 are attached to the peripheral portions of the placement through holes 15a and 15a and laminated. Note that the formation positions of the placement through holes 15a and 15a (that is, the placement positions of the three-dimensional solid knitted fabrics 10 and 10) are generated by the movement accompanying the atrium, ventricle, and aorta (particularly, the “descending aorta”). It is preferable to set the position corresponding to a region in which shaking and movement of the aortic valve can be detected. As a result, the three-dimensional solid knitted fabrics 10 and 10 are sandwiched between the upper and lower surfaces by the plate-shaped foams 21 and 22 and the peripheral portion is surrounded by the three-dimensional solid knitted fabric support member 15. The three-dimensional solid knitted fabric support member 15 functions as a resonance box (resonance box). The wall of the aorta is rich in elasticity among the arteries, and can receive the high pressure of blood that is pumped directly from the heart. There is a certain aortic valve. For this reason, when the position of the three-dimensional solid knitted fabric is set to the above position, the movement of the negative feedback mechanism between the brain and the autonomic nervous system for maintaining the continuity of the living body can be well understood.

  Further, it is preferable to use a material in which the three-dimensional solid knitted fabrics 10 and 10 are thicker than the three-dimensional solid knitted fabric support member 15. That is, when the three-dimensional solid knitted fabrics 10 and 10 are arranged in the placement through holes 15a and 15a, the front and back surfaces of the three-dimensional solid knitted fabrics 10 and 10 protrude from the placement through holes 15a and 15a. Thickness. Thereby, since the three-dimensional solid knitted fabrics 10 and 10 are pressed in the thickness direction when the peripheral portions of the films 16 and 16 are attached to the peripheral portions of the placement through holes 15a and 15a, the reaction force of the films 16 and 16 Tension is generated and solid vibration (membrane vibration) is likely to occur in the films 16 and 16. On the other hand, pre-compression occurs also in the three-dimensional solid knitted fabrics 10 and 10, and the connecting yarn that holds the thickness form of the three-dimensional solid knitted fabric is also subjected to tension due to reaction force, and string vibration is likely to occur. In addition, although it is preferable to provide the films 16 and 16 on both sides of the front side and the back side of the three-dimensional solid knitted fabrics 10 and 10, it is also possible to have a configuration provided on at least one of them.

  Since the connecting yarn of the three-dimensional solid knitted fabric 10, 10 is stretched between a pair of ground knitted fabrics, it becomes a long string wound in a coil shape, and a film that functions as a resonance box (resonance box) at upper and lower nodes. 16 and 16 and plate-like foams 21 and 22 are disposed. Since a biological signal typified by heart rate variability has a low frequency, it is amplified by a resonance system having such a long string and a large number of nodes. That is, the string vibration of the connecting yarn causes the film vibration of the films 16 and 16 and the film vibration of the beads of the plate-like foams 21 and 22 through a large number of nodes, which act in an overlapping manner and are amplified. In addition, the space | interval between the nodes of the connection thread | yarn of a three-dimensional solid knitted fabric, ie, the arrangement | positioning density of a connection thread | yarn, is so preferable.

  Further, the films 16 and 16 are adhered to the plate-like foams 21 and 22 in advance and integrated, and the plate-like foams 21 and 22 are simply laminated on the three-dimensional three-dimensional knitted fabric support member 15. It is also possible to adopt a configuration in which 16 can be arranged on the front side and the back side of the three-dimensional solid knitted fabrics 10 and 10. However, in order to apply pre-compression to the three-dimensional solid knitted fabrics 10, 10, it is preferable to fix the films 16, 16 to the surface of the three-dimensional solid knitted fabric support member 15 as described above. In addition, as shown in FIG. 1, a film is not disposed corresponding to each three-dimensional solid knitted fabric 10, but two two-dimensional solid knitted fabrics 10, 10 are covered as shown in FIG. You may make it use the film 16 of the magnitude | size which can be used.

  For example, a plastic film made of polyurethane elastomer (for example, product number “DUS605-CDR” manufactured by Seadam Co., Ltd.) is preferably used as the films 16 and 16 in order to capture heart rate fluctuation. However, since the films 16 and 16 generate membrane vibration due to resonance if the natural frequencies match, this is not restrictive, and it depends on the object to be collected (heartbeat, breathing, shaking of the atrium, ventricle, and aorta). It is preferable to use one having a natural frequency. For example, as shown in a test example described later, a biaxially formed material made of a material having low stretchability, for example, a nonwoven fabric made of thermoplastic polyester (for example, polyethylene naphthalate (PEN) fiber (1100 dtex) manufactured by Teijin Ltd.) It is also possible to use a woven fabric (length: 20 / inch, width: 20 / inch). Further, for example, an elastic fiber nonwoven fabric having an elongation of 200% or more and a recovery rate of 100% or more at 80% or more (for example, trade name “Espancione” manufactured by KB Seiren Co., Ltd.) It is also possible to use.

  The vibration sensor 30 is fixedly disposed on one of the three-dimensional solid knitted fabrics 10 before the above-described films 16 and 16 are laminated. The three-dimensional three-dimensional knitted fabric 10 is composed of a pair of ground knitted fabrics and connecting yarns, and the string vibration of each connecting yarn is applied to the films 16 and 16 and the plate-like foams 21 and 22 via the nodes with the ground knitted fabric. In order to be transmitted, the vibration sensor 30 preferably fixes the sensing unit 30a to the surface of the three-dimensional solid knitted fabric 10 (the surface of the ground knitted fabric). As the vibration sensor 30, it is preferable to use a microphone sensor, in particular, a condenser microphone sensor. In this embodiment, since it is not necessary to consider the sealing property of the portion where the microphone sensor is disposed (that is, the placement through hole 15a where the three-dimensional solid knitted fabric 10 is disposed), the lead wire of the microphone sensor is easily wired. be able to. In the present embodiment, as described above, the vibration of the body surface via the human muscle and skeleton accompanying the biological signal propagates not only to the three-dimensional solid knitted fabric 10 but also to the plate-like foams 21 and 22 and the film 16. These are vibrated (string vibration, membrane vibration) and superimposed and amplified. Therefore, the vibration sensor 30 is not limited to the three-dimensional solid knitted fabric 10, and the sensing unit 30 a can be fixed to the plate-like foams 21 and 22 and the film 16 constituting the vibration transmission path. In this embodiment, since the three-dimensional solid knitted fabric 10, the three-dimensional solid knitted fabric support member 15, the plate-like foams 21, 22 and the film 16 mechanically amplify the biological signal, these constitute a mechanical amplification device. To do.

  For example, as shown in FIG. 3, the above-described biological signal measuring unit 1 is disposed inside the skin 120 covered by the seat back frame 110 of the automobile seat 100. In order to facilitate the arrangement work, the three-dimensional solid knitted fabric 10, the three-dimensional solid knitted fabric support member 15, the film 16, the plate-like foams 21, 22, the vibration sensor 30 and the like constituting the biological signal measuring means 1 are previously united. It is preferable to make it.

   The biological signal measuring means 1 described above is a mechanical amplification device including a three-dimensional solid knitted fabric 10 and plate-like foams 21 and 22 laminated around the three-dimensional solid knitted fabric 10, preferably the three-dimensional solid knitted fabric 10. And the plate-like foams 21 and 22 have a mechanical amplification device in which a film 16 is disposed, and a vibration sensor is attached to the mechanical amplification device. Microvibrations on the body surface due to human biological signals such as heartbeat, breathing, shaking of the atrium, ventricle, and aorta are propagated to the plate-like foams 21, 22, the film 16, and the three-dimensional solid knitted fabric 10. The foams 21 and 22 and the film 16 cause membrane vibration, and the three-dimensional solid knitted fabric causes yarn string vibration.

  Further, the three-dimensional solid knitted fabric 10 includes a connecting yarn disposed between a pair of ground knitted fabrics, and has a load-deflection characteristic approximate to a load-deflection characteristic of human muscles. Therefore, the load-deflection characteristic of the mechanical amplifying device including the three-dimensional solid knitted fabric 10 is approximated to that of the muscle, and it is arranged adjacent to the muscle, so that the muscle and the three-dimensional solid knitted fabric are arranged. The internal and external pressure differences are equal, and biological signals such as heartbeat, respiration, atrial and ventricular and aortic oscillations can be accurately transmitted, and thus, the yarn (particularly the connecting yarn) constituting the three-dimensional solid knitted fabric 10 can be transmitted. String vibration can be generated. Further, the plate-like foams 21 and 22, preferably bead foams, laminated on the three-dimensional solid knitted fabric 10 tend to cause membrane vibration on each bead due to the soft elasticity and small density of the beads. Since the film 16 has a peripheral edge fixed and elastically supported by a three-dimensional solid knitted fabric that approximates the load-deflection characteristics of human muscles, a predetermined tension is generated, and thus membrane vibration is likely to occur. That is, according to the biological signal measuring means 1, in a mechanical amplifying device having a load-deflection characteristic that approximates a load-deflection characteristic of a muscle by a biological signal such as heartbeat, respiration, atrial, ventricular and aortic swinging. Membrane vibrations are generated in the plate-like foams 21 and 22 and the film 16, and string vibrations are generated in the three-dimensional solid knitted fabric 10 having a load-deflection characteristic approximate to the load-deflection characteristic of human muscles. The string vibration of the three-dimensional solid knitted fabric 10 again affects the film vibration of the film 16 and the like, and these vibrations are superimposed and act. As a result, the vibration input from the body surface along with the biological signal is directly detected by the vibration sensor 30 as a solid vibration amplified by superposition of the string vibration and the membrane vibration.

  As the biological signal measuring means 1 used in the present invention, it is possible to use a conventional configuration for detecting the air pressure fluctuation in the sealed bag, but since the volume and the pressure are in inverse proportion, the sealed It is difficult to detect pressure fluctuations unless the bag volume is reduced. On the other hand, according to the biological signal measuring means 1 described above, it is propagated to the mechanical amplification devices (three-dimensional solid knitted fabric 10, plate-like foams 21, 22, and film 16) as described above, not the air pressure fluctuation. The volume (volume) is rarely limited from the viewpoint of detection sensitivity, and the amplitude associated with heartbeat, breathing, atrial and ventricular and aortic oscillations, etc. Small vibrations can be detected with high sensitivity. For this reason, it can respond to people with various physiques. Therefore, the biosignal measuring means 1 can detect a biosignal with high sensitivity even in an environment where people having various physiques, such as a vehicle seat, and various external vibrations are input. Further, since it is not necessary to make a sealed structure, the manufacturing process is simplified, the manufacturing cost can be reduced, and it is suitable for mass production.

  In addition, although the above-mentioned biological signal measuring means 1 is incorporated in the inside of the skin 120 of the seat 100, it may be incorporated in a seat cushion that is attached to the surface of the skin 120 later. However, when attaching as a retrofit, it is preferable to provide a hard surface between the sheet and the three-dimensional solid knitted fabric so that the three-dimensional solid knitted fabric is likely to be pre-compressed due to the weight. It is preferable to insert a three-dimensional knitted fabric or a plate having a thickness of about 1 to 2 mm made of synthetic resin such as polypropylene. For example, in the case of a sheet having a soft compression characteristic, a three-dimensional solid knitted fabric is not pre-compressed, and thus a biological signal is absorbed without being reflected, but by providing a hard surface as described above, Variations in the compression characteristics on the sheet side are absorbed, and a biological signal having a large amplitude is easily obtained.

  Next, the configuration of the biological state estimation device 60 will be described with reference to FIG. The biological state estimation device 60 includes a frequency calculation unit 610, a frequency gradient time series analysis calculation unit 620, a frequency analysis unit 630, a regression line calculation unit 640, a determination reference point calculation unit 650, and a state estimation unit 660. . The biological state estimation device 60 is configured by a computer, the frequency calculation unit 610 executes a frequency calculation procedure, the frequency gradient time series analysis calculation unit 620 executes the frequency gradient time series analysis calculation procedure, and the frequency analysis unit 630 executes the frequency calculation. An analysis procedure is executed, a regression line calculation procedure is executed by the regression line calculation means 640, a determination reference point calculation procedure is executed by the determination reference point calculation means 650, and a state estimation procedure is executed by the state estimation means 660. The computer program can be provided by being stored in a recording medium such as a flexible disk, a hard disk, a CD-ROM, an MO (magneto-optical disk), a DVD-ROM, or a memory card, or transmitted through a communication line. Is possible.

  The frequency calculation means 610 is time-series data (APW) of the output signal obtained from the vibration sensor 30 of the biological signal measurement means 1, preferably filtering processing (for example, filtering processing for removing frequency components generated by body movement). A time-series waveform of the frequency in the time-series data in the predetermined frequency region is obtained.

  The frequency calculation unit 610 uses a time point waveform of the output signal obtained from the vibration sensor of the biological signal measurement unit 1 and uses a switching point between positive and negative (hereinafter referred to as “zero cross point”) to generate a time series waveform of frequency. And a time series waveform using a local maximum value (peak point) obtained by smoothing and differentiating the time series waveform of the output signal obtained from the vibration sensor of the biological signal measuring means 1 (hereinafter referred to as “zero cross detection means”). There are two methods (hereinafter referred to as “peak detection means”).

  Zero cross detection means is suitable for capturing APW fundamental frequency fluctuation, and peak detection means is heart rate, that is, APW composite wave, for example, frequency fluctuation of high frequency component counted as heart rate and fundamental frequency fluctuation. It is suitable for capturing. In the fluctuation analysis, the slope time series analysis is applied to the time series waveform obtained by the zero cross detection means / peak detection means.

  That is, the absolute value processed waveform of the tilt time series waveform by the zero cross detection means reflects the appearance state of the sympathetic nerve, and the waveform by the peak detection means reflects the appearance state of the parasympathetic nerve. Therefore, we decided to use the zero-cross detection means as an index for stress adaptation that is handled by control of the autonomic nervous system and the resulting physical condition. On the other hand, the frequency fluctuations by the peak detection means mainly linked to the frequency fluctuations of the heart rate are linked to the excitement and sedation caused by feeling comfortable or uncomfortable, or the feeling of satisfaction and dissatisfaction (feeling of pleasure / discomfort). The time series waveform and the fluctuation waveform obtained by frequency analysis of the tilt time series waveform by the zero cross detection means linked to wakefulness and sleep were indexed together.

  The zero-cross detection means (zero-cross procedure) first obtains the zero-cross point, for example, cuts it every 5 seconds, and calculates the reciprocal of the time interval between the zero-cross points of the time-series waveform included in the 5 seconds as the individual frequency f. And the average value of the individual frequencies f in the 5 seconds is adopted as the value of the frequency F in the 5 seconds (step [1] in FIG. 5). A frequency time series waveform is obtained by plotting the frequency F obtained every 5 seconds (step [2] in FIG. 5). The peak detection means (peak detection procedure) obtains a maximum value by, for example, a smoothing differential method using Savitzky and Golay. Next, for example, the maximum value is cut every 5 seconds, and the reciprocal of the time interval between the peak points (the peak portions on the peak side of the waveform) included in the time series waveform included in the 5 seconds is obtained as the individual frequency f. The average value of the individual frequencies f in the second is adopted as the value of the frequency F in the five seconds (step [1] in FIG. 5). A frequency time series waveform is obtained by plotting the frequency F obtained every 5 seconds (step [2] in FIG. 5).

  The frequency gradient time series analysis calculation means 620 is obtained from the frequency time series waveform (APW) of the output signal of the vibration sensor of the biological signal measurement means 1 obtained by the frequency calculation means 610 using the zero cross detection means or the peak detection means. In this configuration, a time window having a predetermined time width is set, the slope of the frequency of the output signal of the vibration sensor is obtained by the least square method for each time window, and the time-series waveform is output. Specifically, first, the frequency gradient in a certain time window Tw1 is obtained by the least square method and plotted (steps [3] and [5] in FIG. 5). Next, the next time window Tw2 is set at the overlap time Tl (step [6] in FIG. 5), and the frequency gradient in this time window Tw2 is similarly obtained by the least square method and plotted. This calculation (movement calculation) is sequentially repeated, and the time-series change in the frequency gradient of the output signal is output as a frequency-gradient time-series waveform (step [8] in FIG. 5). The time width of the time window Tw is preferably set to 180 seconds, and the overlap time Tl is preferably set to 162 seconds. As shown in Patent Document 3 (WO2005 / 092193A1) by the present applicant, this is a characteristic signal waveform from a sleep experiment in which the time width of the time window Tw and the overlap time Tl are variously changed. Is selected as the value that appears most sensitively.

  The frequency analysis unit 630 is a unit that performs frequency analysis on the frequency gradient time-series waveform obtained from the frequency gradient time-series analysis calculation unit 620 and obtains a power spectrum.

  The regression line calculation means 640 is a means for obtaining a regression line for each predetermined period region (frequency range) for the analysis waveform (fluctuation waveform) output from the frequency analysis means 630.

  For each predetermined frequency region in the regression line calculation means 640, as described above, fluctuations that maintain human constancy exist in the VLF region and the ULF region. The periodic area was set. Specifically, such as a long-period region (low frequency band) around 0.0035 Hz around 0.0033 Hz indicating the overall state related to maintenance of homeostasis and a barrier reaction corresponding to the peripheral system They are an intermediate period region (medium frequency band) centered at 0.01 Hz and a short period region (high frequency band) centered at 0.0225 Hz, which are related to stress adaptation and pleasant / unpleasant states. The medium period region centered on 0.01 Hz (medium frequency band) and the short period region centered on 0.0225 Hz (high frequency band) have large amplitudes of fluctuations related to stress adaptation and comfort / discomfort. Since this causes fluctuations and this creates a bifurcation phenomenon, the results of statistical investigation of the places where the amplitude fluctuations are large have been found. Therefore, in the present embodiment, as a range in which these center frequencies become the median value, the long period region is in the range of 0.001 Hz to 0.006 Hz centered on 0.0035 Hz, and the medium period region is 0.01 Hz. The short period region was set to 0.015 Hz to 0.03 Hz, respectively, at 0.006 Hz to 0.015 Hz.

  The regression line calculation means 640 obtains a regression line by the least square method with each center frequency as the median value in each periodic region.

  In addition, the regression line calculation means 640 has a 0.0035 Hz boundary between the ULF region and the VLF region (note that the boundary between the ULF region and the VLF region is 0.0033 Hz, but in this embodiment, for convenience of calculation. Therefore, the long period region is further divided into two, and a unit for obtaining a regression line in the ULF region and a regression line in the VLF region is provided.

  Therefore, the regression line calculation means 640 performs, in the long period region, an operation for obtaining one regression line centered on 0.0035 Hz in the entire long period region and an operation for obtaining each regression line in the ULF region and the VLF region. Run. Further, the regression line calculation means 640 determines whether the product of the slopes of the regression line in the ULF region and the regression line in the VLF region is equal to or less than a predetermined value. If the product is equal to or less than the predetermined value, the ULF region and the VLF region are determined. Each regression line is adopted, and if it exceeds a predetermined value, a regression line centered on 0.0035 Hz in the entire long-period region is adopted.

  This occurs because the long-period region particularly occurs when a person tries to change his / her whole body state greatly, such as a sleep onset sign phenomenon, and thus appears as sleepiness. Then, the VLF region is 1 / f and is represented by one regression line. However, the VLF region becomes larger in an imminent state where sleep is imminent. When this happens, a V-shape and an inverted V-shape appear, and this appears as impending sleepiness. For this reason, if only one regression line centered on 0.0035 Hz is always used, the transitional period of the state change toward sleepiness is widely recognized, and the strength of sleepiness cannot be understood. Therefore, the configuration is such that two regression lines of the ULF region and the VLF region are obtained.

  The determination reference point calculation means 650 gives an area score based on the slope of each regression line obtained for each periodic area by the regression line calculation means 640 and obtains a shape score for each regression line as a whole. A determination reference point for estimating the state of the living body is calculated using at least one of the score and the shape score.

  The area score is a score corresponding to the slope of each regression line. The slope of each regression line is given by dividing it into three substantially horizontal states, upward and downward. In the case of downward, a score higher than the score in the substantially horizontal state is given, and in the case of upward, a score lower than the score in the substantially horizontal state is given. When the tilt is upward, the autonomic nervous system control is enhanced.When the tilt is downward, the autonomic nervous system control is stable. The former is lowered and the latter is raised. Whether or not the slope of the regression line is in a substantially horizontal state can be set, for example, so as to determine that it is in a substantially horizontal state when it falls within a range of ± 1 to ± 10 degrees with respect to the horizontal. In addition, it is thought that the substantially horizontal state shows the endurance state where the direction of control of the autonomic nervous system is not fixed and is in a state of being chaotic or having forced mental control.

  The shape score is a score related to the overall shape including the regression lines obtained by the regression line calculation means 640. Assuming a virtual connection line that virtually connects the ends of adjacent regression lines to each other, the two adjacent regression lines may be almost straight, or the slope difference between two adjacent regression lines Depending on the difference in the value of the power spectral density, there may be a break point between at least one of the regression lines and the virtual connection line. According to the test results disclosed in Japanese Patent Application No. 2011-43428 previously proposed by the applicant, the number of breaks is one or zero in a healthy, awakened, relaxed, and stable state. It is known that the number of break points increases when the subject is healthy but sleepy or is in a fatigue state, and similarly, the number of break points also increases in the diseased state. Therefore, when the difference in power spectral density value between two regression lines in adjacent periodic regions is greater than or equal to a predetermined value, and between two regression lines in adjacent periodic regions, the difference in power spectral density value is predetermined. When the difference between the inclination angles of the two regression lines is equal to or larger than a predetermined angle set in advance, each is counted as a break point. In addition, when the difference between the values of the power spectral density values of two adjacent regression lines is within a predetermined range, and the difference between the inclination angles of the two regression lines is within a predetermined angle, it is regarded as a straight line. It is determined that there is no break point between them.

  In this embodiment, the shape score is set so that the smaller the number of break points, the higher the score. For example, when there are 3 break points: 0 points, when there are 2 break points: 1 point, when there is 1 break point: 2 points, when there are no break points: 3 points. Note that this is merely an example, and by setting in this way, the score becomes higher as the subject is healthy, relaxed, and stable, but for example, it is also possible to set the opposite.

  The state estimation unit 660 estimates the state of the living body based on the time series change of the determination reference point of each analysis waveform (fluctuation waveform) obtained by the determination reference point calculation unit 650. As described above, the judgment reference point is a state related to physical condition such as maintenance of homeostasis, adaptation to stress, comfort / discomfort, fatigue, non-disease, illness, and health (here, including “general condition”) The frequency of the fluctuation waveform related to (1) is scored on a constant basis. Therefore, the time-series change of the score can estimate how the whole body condition has changed, and further, from the tendency, the possibility of a change in the state that can occur in the future, especially the sudden change from the current homeostatic state. Can be estimated. As long as the state estimation unit 660 can capture such a time-series change of the determination reference point and can estimate the change of the state, the method is not limited, but in the present embodiment, the change of the physical condition The following two methods suitable for estimation of the above and changes in the general state were used.

A) State estimation means 660 suitable for estimating changes in physical condition:
Between the judgment reference points of the analysis waveform in the two time ranges before and after the comparison target, the following formula:
Function point = Judgment reference point of the later time range + (Judgment reference point of the later time range-Judgment reference point of the previous time range) x n (where n is a correction coefficient)
This is a means for obtaining the functional points obtained by the above in time series.

  Note that n (correction coefficient) is determined by the number of frequency regions (frequency bands) to be analyzed. In the present embodiment, n = 3 is set because changes in the three frequency domains of the long period area, the medium period area, and the short period area are captured.

  Further, the determination reference point used here is a score obtained by combining the region score and the shape score. Area scores indicate the stability of fluctuations to maintain homeostasis, and shape scores estimate and identify health and disease states from bifurcation phenomena. It is preferable to use the combined score. The time-series change of this functional point changes on the positive side when favorable, and on the negative side when not good. Therefore, it is possible to easily determine the time change between good and bad. In this means, when the frequency time-series waveform is obtained by the zero cross detection means, the state of change relating to homeostasis related to the sympathetic nerve is obtained, and when the frequency time-series waveform is obtained by the peak detection means, A state of change related to homeostasis related to parasympathetic nerves is obtained. In the general state, homeostasis is maintained by controlling the autonomic nervous system, and the state of control and the general state change according to the balance between the sympathetic nerve and the parasympathetic nerve.

B) State estimation means 660 suitable for estimating changes in the general state:
From the first determination reference point obtained from the frequency time-series waveform using the zero-cross detecting means indicating the active state of the sympathetic nervous system and the time-series waveform of the frequency using the peak detecting means indicating the active state of the parasympathetic nervous system The obtained second determination reference point is used, the index based on the first determination reference point is taken on one axis, the index based on the second determination reference point is taken on the other axis, and the first determination reference point and This is a means for obtaining the state of change of the whole body state obtained from the two determination reference points as a time series change of coordinates.

  A time-series change that combines the first determination reference point and the second determination reference point is obtained as follows. For example, the first determination reference point obtained using the zero cross detection means is taken as the horizontal axis, and the second determination reference point obtained using the peak detection means is taken as the vertical axis. The frequency gradient time series waveform using the zero cross detection means represents the state of the sympathetic nerve as described above, and the frequency gradient time series waveform using the peak detection means represents the state of the parasympathetic nerve as described above. Therefore, the coordinate system shows a state where the parasympathetic nerve is dominant and the parasympathetic nerve is small, the parasympathetic nerve is dominant and the sympathetic nerve is small, and an intermediate state thereof.

  Specifically, a region where the sympathetic nerve is dominant and the parasympathetic nerve is small is defined as an active / resistance region, and a case where the parasympathetic nerve is dominant and the sympathetic nerve is small is defined as a resistance / adaptation region. The intermediate state of the process in which the function decreases from the sympathetic nerve-enhanced state to the parasympathetic dominant state is defined as the resistance / resistance region, and the process in which the sympathetic nerve increases from the parasympathetic dominant state to the sympathetic dominant state The intermediate state was defined as the active / adapted region. Then, the coordinate system was set so that the four quadrants of the coordinate system correspond to these (see FIG. 6 (e)).

  The state estimation means 660 uses the first determination reference point and the second determination reference point obtained for each analysis waveform (fluctuation waveform) in a predetermined time width, and plots them in the coordinate system set as described above. , Create a coordinate time series change line connecting them in time series. Specifically, first, as the initial value, each function point obtained from each of the first and second determination reference points in the first measurement time width is used. Using the initial coordinates as a reference, the following coordinates are plotted using the slopes of the regression lines used for the first and second determination reference points obtained for each time width, and all the coordinates are connected. Create a series change line. In the present embodiment, for example, when plotting coordinates relating to the next time width from the initial value, the movement width on the coordinates is set for each slope and the plot position is obtained for the slope of the regression line obtained in the time width. That is, when the regression line is in a substantially horizontal state, it is set to zero in any case, and the plot position is moved when it is upward or downward without moving in any direction. In the present embodiment, the regression line obtained by the zero cross detection means is set so that it moves -1 when it is upward and +1 when it is downward, and the regression line obtained by the peak detection means is upward. In this case, the movement is set to +1, and in the case of downward, the movement is set to -1. Thereby, a coordinate time series change line is created.

  FIG. 6 shows a specific method for creating the coordinate time-series change line created by the state estimation unit 660 in the present embodiment.

  First, the initial position is plotted. For example, if the functional point obtained from the first determination reference point using the zero cross detection means is +2 and the functional point obtained from the second determination reference point using the peak detection means is +4, the horizontal axis ( The coordinates of X axis) = + 2 and the vertical axis (Y axis) = + 4 are plotted as initial positions (FIG. 6E).

  Next, based on the regression line of the analysis waveform from 4.8 to 30 min, the coordinates are moved to a position indicating the whole body state after 30 minutes. The regression line in the long-period region of the analysis waveform using the zero cross detection means is downward, so that the X-axis is +1, the middle-cycle region is straight upward, the regression line is -1, and the short-cycle region regression line is downward Therefore, it is moved in the order of +1 on the X axis (FIG. 6A). Since the regression line in the long period region of the analysis waveform using the peak detection means is downward, the regression line in the Y axis is −1, the regression line in the middle period region is downward, −1 in the Y axis, and the regression line in the short period region is Since it is substantially horizontal, it is moved in order from 0 (FIG. 6C). As a result, as shown in FIG. 6E, the position of the whole body state after 30 minutes is obtained.

  Next, based on the regression line of the analysis waveform of 16.8 to 36.6 min, the coordinates are moved to a position indicating the whole body state after 37 minutes. The regression line of the long period region of the analysis waveform using the zero cross detection means is upward, so that the X axis is −1, the middle period region of the regression line is upward, −1 on the X axis, and the short period region of the regression line is Since it is downward, it is moved in the order of +1 on the X axis (FIG. 6B). Since the regression line in the long period region of the analysis waveform using the peak detection means is downward, the regression line in the Y axis is −1, the regression line in the middle period region is downward, −1 in the Y axis, and the regression line in the short period region is Since it is downward, it is moved in order of -1 on the Y axis (FIG. 6D). As a result, as shown in FIG. 6E, the position of the whole body state after 37 minutes is obtained. A coordinate time-series change line is created by connecting the coordinates of the initial position, the position indicating the whole body state for 30 minutes, and the position indicating the whole body state for 37 minutes.

  When the state estimation unit 660 creates the coordinate time series change line in this way, the state estimation unit 660 determines in which region each coordinate time series change line is mainly included. That is, the active / resistance region (quadrant indicated by “Foo-Foo” in the figure (Foo-Fu region)), the tolerance / adaptive region (quadrant indicated by “Yu-Yu” in the drawing (Yu-Yu region)), and the tolerance / resistance region (“ It is determined whether it is included in the quadrant (hetthorn region) indicated by “Hetohet”) or the active / adaptive region (quadrant (hatsuhatsu region) indicated by “hatsuhatsu” in the figure) (coordinates shown in FIG. 17B) reference). It is determined that the active / resistance region (Fu Fu region) is stable with sympathetic dominance, and the state of high aggression continues, and if it is the tolerance / adaptation region (Yuyu region), it is stable with parasympathetic dominance. A region where you feel that you are feeling relaxed when it is judged that you are in a relaxed state, and if you are in a tolerance / resistance region (hetoheto region), the parasympathetic nerve is declining while the sympathetic nerve function is decreasing. If it is an active / adapted region (sparkling region), it is determined that the sympathetic nerve is enhanced and the state is shifting from the parasympathetic dominant state to the sympathetic dominant state and the concentration level is high and tense.

Here, in FIG. 17B, a 45 degree oblique line is set in each quadrant. The shaded area is the portion where the above-described region feature is most apparent. For example, if the state in which the sympathetic nerve activity is clearly superior to the parasympathetic nerve activity continues over a predetermined measurement time, the coordinates are plotted on the 45-degree diagonal line of the fu-fu region. However, in reality, various parasympathetic nerve activities are performed in the sympathetic nerve dominant, and both the sympathetic nerve activity and the parasympathetic nerve activity change, and therefore, they are not necessarily plotted on the diagonal lines, Features may be mixed, or features in the hefty region may be mixed. For this reason, by dividing each region by 45 degrees oblique lines, for example, when coordinates are plotted on the upper right side of the oblique lines in the foo-fu region, at that time, while the features of the foo-fu region are high, If the coordinates are plotted on the lower left side, the features of the hoo-hue region are mixed even though the features of the fu-fu region are high.
In the coordinate system shown in FIG. 17B and the determination results of each test example described later (FIGS. 16, 23, 32, 41, and 52), the positive side of the horizontal axis is “adaptive”, minus The side is set to “resistance”, the positive side of the vertical axis is set to “activity”, and the negative side is set to “resistance”. This can be expressed in psychological terms as follows. That is, the horizontal axis related to the sympathetic nerve activity becomes “positive“ exhibition ”large” as the value increases in the positive direction, and “minus“ exhibition ”large” as the value increases in the negative direction. The vertical axis related to parasympathetic nerve activity becomes “positive“ required ”large” as the value increases in the positive direction, and “negative“ required ”large” as the value increases in the negative direction. . Then, the closer to the coordinate origin (0, 0), the smaller the “demonstration” and “required”. In this way, in terms of psychology, for example, the “hatsatsu area” is a “plus“ demonstration ”large” and “plus“ demanded ”large” area.・ Matches the meaning of the area expressed as “uplifting, tension, and joy”.

  The state estimation unit 660 determines that each coordinate time series change line has a change tendency approximate to a 1 / f slope, and determines that the change is in the vertical direction. In some cases, it may be set to be determined as uncomfortable. For example, in the active / resistance region, it can be estimated that the closer the inclination of the coordinate time series change line is to 1 / f inclination, the higher the aggression, and the relatively relaxed tendency because the feeling of comfort is high. On the contrary, if the coordinate time series change line extends in the vertical direction in the tolerance / adaptive region, it can be estimated that the function is deteriorated due to high discomfort even in the relaxed base state, which is useful for finer state estimation.

  On the other hand, the state estimation unit 660 performs the entire process of one coordinate time series change line obtained in a certain state (a certain time zone) and another coordinate time series change line obtained in another state (another time zone). The main direction of movement is determined.

  And when the main direction of movement is between active / adaptive area and tolerance / adaptive area, it is estimated that it shows healthy fatigue and stabilization tendency in a state of fatigue in good physical condition. However, if it is between the active / resistance region and the tolerance / adaptation region, it is assumed to be a normal state with a relatively gentle change, and if it is between the resistance / resistance region and the activity / adaptation region, it is abrupt. It is presumed that the rebound caused by a change or change, that is, a state of suggesting the possibility of sudden change in physical condition. As described above, these regions are regions set corresponding to the state of the sympathetic nerve and the parasympathetic nerve, and when moving between the active / adaptive region and the tolerance / adaptive region, Since it is a movement between the state where sympathetic nerve enhancement is performed and there is a state of fluttering in a relaxed state, it can be estimated that the change is in a healthy and healthy state. When moving between the active / resistance region and the tolerance / adaptation region, the sympathetic nerve dominant state and the parasympathetic nerve dominant state are switched. This is a range of normal physical condition and sense switching, and can be estimated as a change in the normal state. When it is between the tolerance / resistance region and the active / adaptation region, it is a sudden change between a state of feeling sensation and a state of feeling a sensation, and the physical condition itself does not follow the sudden change. It can be estimated that there is a risk of sudden change. Note that the “main movement direction” means that the coordinate time-series change line may move across a plurality of regions, so the movement amount along the Y axis or the movement amount along the oblique virtual axis. Is larger than the amount of movement along the other axis.

  Hereinafter, the determination method in the determination unit 660 will be described in more detail based on test examples.

(Test Example 1)
The biosignal measuring means 1 shown in FIG. 1 is laminated on the back side of the product name “Twin Lumber” made by Delta Touring Co., Ltd., seat cushion, attached to the car seat, seated on the subject, and sitting posture A biological signal, i.e., a so-called body surface pulse wave (hereinafter referred to as “heart swing wave”, but may be abbreviated as “APW”), was collected by swinging of the atrium, ventricle and aorta. The plate-like foams 21 and 22 and the three-dimensional three-dimensional knitted fabric support member 15 constituting the biological signal measuring means 1 were bead foams having an average bead diameter of about 5 mm and slice-cut to a thickness of 3 mm. The three-dimensional solid knitted fabric 10 was manufactured by Sumie Textile Co., Ltd., product number: 49011D, and had a thickness of 10 mm. As the film 16, a product number “DUS605-CDR” manufactured by Seadam Co., Ltd. was used. The test subject is a healthy man in his 70s. In addition, a test in which the above-mentioned automobile seat was mounted on the passenger seat and measured under static conditions in a stopped state, and an actual vehicle running test that was measured while running the automobile were performed.

  The heart fluctuation wave obtained from the biological signal measuring means 1 is processed by applying a zero cross (0x) detecting means and a peak detecting means in the frequency calculating means 610, and a time series waveform of the frequency is obtained for each, The time series waveform of each frequency was processed by the frequency slope time series analysis calculation means 620 to obtain the time series waveform of the frequency slope. Next, the frequency analysis unit 630 performs frequency analysis on each time-gradient waveform of each frequency gradient to obtain a power spectrum, and analyzes the frequency (logarithmic value) on the horizontal axis and the power spectral density (logarithmic value) on the vertical axis. The waveform (fluctuation waveform) was displayed.

  7 and 8 show the results of tests performed under static conditions, FIG. 7 shows the results obtained by applying the zero-cross detection means, and FIG. 8 shows the results obtained by applying the peak detection means. Is the result. (A) of FIG.7 and FIG.8 is an analysis waveform of 4.8-30.3min of measurement start, (b) is an analysis waveform of 4.8-19.8min, (c) is 5.1. The analysis waveform of ˜24.9 min, (d) is the analysis waveform of 10.2 to 30.3 min, and the scores described in each of the drawings (a) to (d) are obtained by the determination reference point calculation means 650. (E) shows the function points obtained from them.

  When determining the area score of this determination reference point, the case where the regression line was within ± 4.5 degrees with respect to the horizontal was regarded as a substantially horizontal state. Also, if the difference between the power spectral density values of two adjacent regression lines is less than 0.2 logarithmically, and the difference in the inclination angle of the two regression lines is less than 15 degrees, it is regarded as a straight line. It is determined that there is no break point between them. In addition, the area score was set to 0 in the upward direction and 2 in the downward direction, with 1 point as a reference in a substantially horizontal state. The shape score is set to 3 points when there is no break point, 2 points when there is 1 break point, 1 point when there are 2 break points, and 3 points when there are 3 break points. .

  Accordingly, in the analysis waveform of FIG. 7A for obtaining the first determination reference point using the zero-cross detection means, the regression line is downward in both the long period area, the middle period area, and the short period area. Since 2 + 2 + 2 = 6 points and there are three break points, the shape score is 0 points. Therefore, the first determination reference point is 6 points in total. In the analysis waveform of FIG. 7B, since the regression line is downward in all of the long period area, the medium period area, and the short period area, the area score is 2 + 2 + 2 = 6 points, and there are 0 break points. The score is 3 points. Therefore, the first determination reference point is 9 points, which is a combination of both. In the analysis waveform of FIG. 7C, the long period region is downward, the middle period region is upward, and the short period region is in a substantially horizontal state, so the region score is 2 + 0 + 1 = 3 points and there are three break points. The shape score is 0, and the first determination reference point is 3. In the analysis waveform of FIG. 7D, since the long-period region is downward, the middle-period region is upward, and the short-period region is upward, the region score is 2 + 0 + 0 = 2 points, and there are three break points, so the shape score Is 0, and the first determination reference point is 2.

  On the other hand, in the analysis waveform of FIG. 8A for obtaining the second determination reference point using the peak detection means, the regression line is downward in both the long period region, the middle period region, and the short period region, so the region score is 2 + 2 + 2 = 6 points, and since there are 3 break points, the shape score is 0 points. Therefore, the second determination reference point is 6 points in total. In the analysis waveform of FIG. 8 (b), since the regression line is downward for both the long period region and the middle period region and the short period region, the area score is 1 + 2 + 2 = 5 points, and there is one break point. Therefore, the shape score is 2 points. Therefore, the second determination reference point is 7 points in total. Since the analysis waveforms in FIGS. 8C and 8D are all downward in the long period area, the medium period area, and the short period area, the area score is 2 + 2 + 2 = 6 points, and there are three break points. Therefore, the shape score is 0 point, and the second determination reference points are all 6 points.

  9 to 10 are test results when traveling between “Otani SA and Yoshima PA”, and FIG. 9 is a result obtained by applying the zero cross detection means. The score shown in (d) indicates a first determination reference point obtained by combining the region score and the shape score, and (e) indicates a functional point obtained using the first determination reference point. FIG. 10 shows the results obtained by applying the peak detection means, and the scores shown in FIGS. 10 (a) to 10 (d) indicate the second determination reference points obtained by combining the region scores and the shape scores. (E) shows a functional point obtained using the second determination reference point.

  FIGS. 11 to 12 are test results when traveling between “Yoshima PA and Yamakoshi”, and FIG. 11 is a result obtained by applying the zero cross detection means, and FIGS. The score shown in c) indicates a first determination reference point obtained by combining the area score and the shape score, and (d) indicates a functional point obtained using the first determination reference point. FIG. 12 shows the results obtained by applying the peak detection means, and the scores shown in FIGS. 12 (a) to 12 (c) indicate the second determination reference points obtained by combining the region scores and the shape scores. (D) indicates functional points obtained using the second determination reference points.

  FIGS. 13 to 14 are test results when traveling between “Yamakoshi and Ishizuchiyama SA”, and FIG. 13 is a result obtained by applying the zero-cross detection means, and FIGS. The score shown in g) indicates a first determination reference point obtained by combining the region score and the shape score, and (h) indicates a functional point obtained using the first determination reference point. FIG. 14 shows the results obtained by applying the peak detection means, and the scores shown in FIGS. 14A to 14G indicate the second determination reference points that combine the region scores and the shape scores. (H) indicates a functional point obtained using the first determination reference point.

  FIG. 15A is a diagram in which functional points are obtained from the first determination reference points to which the zero cross detection means of FIGS. 7, 9, 11 and 13 are applied by the state estimation means 660 and plotted in time series. It is.

  For example, in the static state, as shown in FIG. 7E, first, the initial value is the first determination reference point of “4.8 to 19.8 min” as “the determination reference point of the previous time range”. The first determination reference point of “4.8-30.3 min” is used as the “determination reference point of the later time range”. When this is applied to the above equation, 6+ (6-9) × 3 = −3 points becomes a functional point. The functional point of 25 minutes uses the first determination reference point of “4.8 to 19.8 min” as the “determination reference point of the previous time range”, and “5.1 to“ the determination reference point of the subsequent time range ”. The first determination reference point of “24.9 min” is used. When this is applied to the above equation, the functional point of 25 minutes is 3+ (3-9) × 3 = −15 points. The 30-minute functional point uses the first determination reference point of “5.1 to 24.9 min” as the “previous time range determination reference point” and the “next time range determination reference point” as “10. A first determination reference point of “30.3 min” is used. When this is applied to the above equation, the functional point for 30 minutes is 2+ (2-3) × 3 = −1 point.

  As shown in FIG. 9E, the functional points when traveling between “Otani SA and Yoshima PA” are the initial value = −6 points, 40 minutes = 6 points, and 50 minutes = 3 points. As shown in FIG. 11D, the functional points when traveling between “Yoshima PA and Yamakoshi” are the initial value = −4 points and 40 minutes = −4 points. As shown in FIG. 13H, the functional points when traveling between “Yamagoe and Ishizuchiyama SA” are as follows: initial value = 6 points, 40 minutes = 20 points, 50 minutes = 4 points, 60 minutes = 15 Points, 70 minutes = −19 points, 80 minutes = 10 points.

  FIG. 15B is a diagram in which functional points are obtained from the second determination reference points to which the peak detecting means of FIGS. 8, 10, 12 and 14 are applied by the state estimating means 660 and plotted in time series. It is. The calculation method is the same as described above, and the functional points in the static state are the initial value = 3 points, 25 minutes = 3 points, and 30 minutes = 8 points, as shown in FIG. As shown in FIG. 10E, the functional points when traveling between “Otani SA and Yoshima PA” are the initial value = 11 points, 40 minutes = −3 points, and 50 minutes = 7 points. As shown in FIG. 12D, the functional points when traveling between “Yoshima PA and Yamakoshi” are the initial value = 5 points and 40 minutes = 13 points. As shown in FIG. 14H, the functional points when traveling between “Yamagoe and Ishizuchiyama SA” are as follows: initial value = 2 points, 40 minutes = 6 points, 50 minutes = 19 points, 60 minutes = 15. Points, 70 minutes = -15 points, 80 minutes = 19 points.

  From FIG. 15 (a), the functional point obtained using the zero cross detection means changes on the negative side, that is, on the malfunctioning side in the static state before traveling. However, when the vehicle starts to run, the function points shift on the positive side, that is, on the positive side. Therefore, it can be said that this test subject tends to become favorable because the sympathetic nerve is activated in the running state from the transition of the functional point obtained by using the zero cross detecting means.

  In FIG. 15 (b), the functional points obtained using the peak detecting means including the static state before traveling and during traveling are almost positive, that is, favorable, and are relaxed as a whole. It can be said.

  However, in the 70 minutes when traveling between “Yamakoshi and Ishizuchiyama SA”, both the functional point obtained using the zero-cross detecting means and the functional point obtained using the peak detecting means are −15 points. Yes, it can be seen that at 70 minutes, the degree of malfunction has increased.

  On the other hand, in FIG. 16, the state estimation unit 660 takes the index based on the first determination reference point on the horizontal axis (X axis) and the index based on the second determination reference point on the vertical axis (Y axis). It is the figure which calculated | required the time-sequential change of the coordinate calculated | required from this determination reference point and the 2nd determination reference point. The calculation method is as described in FIG. 6, in a static state, when traveling between “Otani SA and Yoshima PA”, when traveling between “Yoshima PA and Yamakoshi”, and between “Yamagoe and Ishizuchiyama SA” For each of the runs, a coordinate time series change line was drawn on the coordinate system.

  For example, in the static state, as the initial position, the coordinates of the functional points of the initial values in FIGS. 7 and 8: (functional points obtained using zero-cross detecting means, functional points obtained using peak detecting means) = (− 3,3) is plotted. Next, in “4.8 to 19.8 min”, the position is moved to +3 in the X-axis direction and −2 in the Y-axis direction, and the position of the whole body state after 20 minutes is plotted at (0, 1). Next, in “5.1 to 24.9 min”, 0 is moved in the X-axis direction, −3 is moved in the Y-axis direction, and the position of the whole body state after 25 minutes is plotted at (0, −2). Next, in “10.2 to 30.3 min”, the position is moved to −1 in the X-axis direction and −3 in the Y-axis direction, and the position of the whole body state after 30 minutes is plotted at (−1, −5). Then, the coordinate time series change line in the static state is created by connecting these coordinates.

  Similarly, coordinate time-series change lines are created for traveling between “Otani SA and Yoshima PA”, traveling between “Yoshima PA and Yamakoshi”, and traveling between “Yamakoshi and Ishizuchiyama SA”.

  From this figure, the main movement direction of the coordinate time-series change line between the states is between the active / resistance region and the tolerance / adaptive region, and can be estimated as the normal state. FIG. 17A shows the sensory evaluation of the subject. The movement direction of the sensory evaluation value coincides with the movement direction of the coordinate time-series change line.

  On the other hand, when the coordinate time-series change lines are individually viewed, both tend to decrease along the vertical axis from the initial position. This is because fatigue accumulates and the body relaxes in the process of transitioning to a sleep state, and thus shifts to a parasympathetic dominant state. The manner of this transition is the same as the transition of the sensory evaluation value in FIG.

  Looking more closely, in the static state, it changed from the state where the Fu-Fu area and the Hatsatsu area were mixed to the state where the Hetohe area and the Yuu-Yu area were mixed, and was in a healthy state immediately after boarding for the test. However, it can be determined that fatigue has accumulated during data measurement in a vehicle in a static state. Between “Yoshima PA and Yamakoshi”, the sympathetic nerve activity has been activated due to running, although the characteristics of the Hatsutsu region in the Fu-Fu region have changed to a state in which the Hetohet region has been mixed. It can be determined that fatigue has accumulated. When traveling between “Otani SA and Yoshima PA”, the Fu-Fu area and the Hatsura area are mixed, and the sympathetic dominant state is maintained as a whole, but it is almost perpendicular to the vertical axis. Since it is decreasing, it can be determined that accumulation of fatigue has occurred.

  Here, from about 19 minutes in the static state, between “Yamakoshi and Mt. Ishizuchi SA”, the subject became a sleep state after 30 minutes (observation of the observer and self-report of the subject after the measurement). In the static state, sleep with a high sense of restraint results in poor quality sleep, and the coordinate time-series change line descends in a state close to vertical, leaving a feeling of fatigue despite wanting to sleep. On the other hand, looking at the coordinate time-series change line between “Yamakoshi and Ishizuchiyama SA”, the characteristics of the Yuyu area gradually increase from the Hatsura area, and after 30 minutes, the slope is close to 1 / f. This indicates that the subject was relaxed and had a good quality sleep. However, from 40.2 minutes onward, it can be seen that the inclination is disturbed and the sleep is slightly worse and the feeling of fatigue remains and the sleep quality is slightly worse. Looking at the sensory evaluation values in FIG. 17A, it is considered that the degree of satisfaction has increased between “Yamagoe and Ishizuchiyama SA”, and the effect of sleep has appeared.

(Test Example 2)
The biosignal measuring means 1 shown in FIG. 1 is laminated on the back side of the product name “Twin Lumber” made by Delta Touring Co., Ltd., seat cushion, attached to the car seat, seated on the subject, and sitting posture A biological signal (hereinafter referred to as “heart swing wave”, but sometimes abbreviated as “APW”) due to swinging of the atrium, ventricle, and aorta in the arousal guiding posture (shown as “wakening posture” in the figure)) Were collected. In addition, even when the seatback is in a sitting position (relaxed position (shown as “sleeping position” in the figure)) in which the opening of the thigh and the spinal column is wider than the normal sitting position (wake-up guiding position) Collected. The other structure of the biological signal measuring means 1 is the same as that of Test Example 1, and the subject is a healthy male in his 40s. 25 and 26 show the results of analysis based on the electroencephalogram, fingertip volume pulse wave, and heartbeat measured during the test. FIG. 25 shows the result of the awakening induced posture, and FIG. 26 shows the result of the relaxed posture. In the wakefulness induction posture, the subject was in the wakefulness state during the test, and in the relaxed posture, the subject was in the sleep state during the middle and final stages of the test.

  (A) of FIGS. 18-21 is an analysis waveform of 4.8-30.3min of measurement start, (b) is an analysis waveform of 4.8-19.8min, (c) is 5.1. (D) is an analysis waveform of 10.2 to 30.3 min, and the score shown in each figure is a determination reference point obtained by the determination reference point calculation means 650. .

(Wake-up posture (displayed as “wake-up posture” in the figure))
The first determination reference points using the zero-cross detection means are 3 points in FIG. 18A, 6 points in FIG. 18B, 3 points in FIG. 18C, and 3 points in FIG. It was. The second determination reference points using the peak detecting means are 4 points in FIG. 19 (a), 4 points in FIG. 19 (b), 3 points in FIG. 19 (c), and 4 points in FIG. 19 (d). It was.

(Relaxing posture (shown as “sleeping posture” in the figure))
The first determination reference points using the zero cross detecting means are 4 points in FIG. 20A, 5 points in FIG. 20B, 9 points in FIG. 20C, and 6 points in FIG. 20D. It was. The second determination reference points using the peak detecting means are 3 points in FIG. 21 (a), 8 points in FIG. 21 (b), 7 points in FIG. 21 (c), and 4 points in FIG. 21 (d). It was.

  FIG. 22 shows a functional point obtained from the first determination reference point to which the zero-cross detection unit in FIGS. 18 and 20 is applied by the state estimation unit 660 and a second in which the peak detection unit in FIGS. 19 and 21 is applied. It is the figure which plotted the function point calculated | required from the determination reference point in time series, respectively. The method of obtaining is the same as in Test Example 1, and all of them are in the range of -5 points to +5 points, and are within the fluctuation range in the normal state. In addition, the functional point by the zero cross detection means in the relaxed posture becomes +20 points or more in 25 minutes, and it can be seen that it is a recovery process of physical condition. Therefore, although this test subject is in a normal health state as a whole, it can be seen that the physical condition (fatigue) can be recovered by sleeping. In the experiment, the sleep state was performed in a relaxed posture and the awake state was performed in a wake-inducing posture, and APW was collected. In addition, the sleep was awakened, that is, the relaxed posture was followed by the awakening induced posture.

  In FIG. 23, the state estimation means 660 takes the index based on the first determination reference point on the horizontal axis (X axis) and the index based on the second determination reference point on the vertical axis (Y axis). It is the figure which calculated | required the time-sequential change of the coordinate calculated | required from a reference point and a 2nd determination reference point. The method of obtaining is the same as in Test Example 1, and the coordinate time-series change lines in two states of “wakefulness induction posture” and “relaxation posture” are drawn.

  As a result, the main movement direction of the coordinate time-series change line is generally between the active / resistance region and the tolerance / adaptive region, and can be estimated as a normal state.

  On the other hand, when the coordinate time-series change lines are individually viewed, both tend to decrease along the vertical axis from the initial position. This is because fatigue accumulates and the body relaxes in the process of transitioning to a sleep state, and thus shifts to a parasympathetic dominant state.

  More specifically, the arousal induction posture changes in a region where characteristics of the fu-fu region and the het-heto region are mixed, and can be determined as a process of shifting from a sympathetic dominant state to a parasympathetic dominant. Further, it can be seen that the experiment in the awakening guidance posture was performed in a state where the amount of change in the coordinate time series change line was small and there was little fatigue. On the other hand, the coordinate time-series change line in the relaxed posture is a region close to the characteristics of the het-heto region even though it is in the Yuu-Yu region, and it can be said that the basic physical condition is somewhat awkward, but the slope of the coordinate time-series change line is 1 It is possible to determine that it is close to / f, has a relatively good quality sleep, and is in the process of function recovery while using a relaxed state. I understand.

(Test Example 3)
For male subjects in their 20s, under the same conditions as in Test Example 2, a normal sitting posture (wakefulness-inducing posture (shown as “wakefulness posture” in the figure)) and a sitting posture with a wide opening of the thigh and spine (relaxed) A biological signal (APW) was collected in the posture (shown as “sleeping posture” in the figure). 34 and 35 show the analysis results based on the electroencephalogram, fingertip plethysmogram, and heartbeat measured during the test. FIG. 34 shows the result of the awakening induced posture, and FIG. 35 shows the result of the relaxed posture. From these figures, it can be seen that the subjects tend to be slightly dull in the first half but are awake in the second half.

  (A) of FIGS. 27-30 is an analysis waveform of 4.8-19.8min of measurement start, (b) is an analysis waveform of 4.8-30min, (c) is 20.1-39. .9 min analysis waveform, (d) is 30 to 49.8 min analysis waveform, and (e) is 40.2 to 60 min analysis waveform. The scores described in each of the drawings (a) to (e) are the determination reference points obtained by the determination reference point calculation means 650. Moreover, (f) of each figure shows the calculated functional point.

(Wake-up posture (displayed as “wake-up posture” in the figure))
The first determination reference point using the zero cross detection means is 6 points in FIG. 27A, 4 points in FIG. 27B, 5 points in FIG. 27C, 6 points in FIG. In 27 (e), it was 8 points. The second determination reference points using the peak detecting means are 4 points in FIG. 28 (a), 4 points in FIG. 28 (b), 7 points in FIG. 28 (c), 7 points in FIG. In 28 (e), it was 4 points.

(Relaxing posture (shown as “sleeping posture” in the figure))
The first determination reference point using the zero cross detection means is 7 points in FIG. 29A, 4 points in FIG. 29B, 2 points in FIG. 29C, 8 points in FIG. In 29 (e), it was 3 points. The second determination reference points using the peak detecting means are 6 points in FIG. 30A, 4 points in FIG. 30B, 2 points in FIG. 30C, 1 point in FIG. In 30 (e), it was 4 points.

  FIG. 31A shows the function points obtained from the first determination reference point to which the zero cross detection means of FIGS. 27 and 29 are applied by the state estimation means 660, and FIG. 31B shows the state estimation means 660. FIG. 31 is a diagram in which the functional points obtained from the second determination reference points to which the peak detection means of FIGS. 28 and 30 are applied are plotted in time series. The method of obtaining is the same as in Test Example 1.

  Looking at the results using the zero-cross detection means, the functional point gradually increases in the arousal induction posture, and the sympathetic nerve is gradually activated. In the relaxed posture, the functional point suddenly increased in the middle, but suddenly decreased at the end of the measurement, and the up and down movement of the sympathetic nerve activity was large. It can be said that this means that the test subject can withstand the local pain caused by maintaining a relaxed posture without being able to relax. In light of the result of using the peak detection means, it can be seen that the function of the parasympathetic nerve is gradually decreased in the arousal induction posture, and the sympathetic nerve dominates. On the other hand, in the relaxed posture, the first half continued to endure, but after 50 minutes it showed a sudden rise in the functional point, and although it was accompanied by fatigue, it was presumed that it was relaxed in the parasympathetic dominant it can.

  In FIG. 32, the state estimation means 660 takes the index based on the first determination reference point on the horizontal axis (X-axis) and the index based on the second determination reference point on the vertical axis (Y-axis). It is the figure which calculated | required the time-sequential change of the coordinate calculated | required from a reference point and a 2nd determination reference point. The method of obtaining is the same as in Test Example 1, and the coordinate time-series change lines in two states of “wakefulness induction posture” and “relaxation posture” are drawn.

  As a result, the main movement direction of the coordinate time series change line is generally from the mixed range of the Fu-Fu area and the Hetoheto area to the mixed area of the Hetoheto area and the Yuyu area, so it is close to the moving direction in the normal state, but as a whole It can be determined that the person feels dull and feels sick. In fact, this subject was slightly cold, fevered the day after the test, and found to have influenza.

  On the other hand, when the coordinate time-series change lines are individually viewed, the wakefulness-inducing posture of the two coordinate time-series change lines changes in the heel-height region and the yuyu-yu region. It shows signs of discomfort, but after that it has a slope close to 1 / f. It can be seen that the subject is asleep in the middle of the 1 / f fluctuation and is awake after that, but is also relaxed in the awake state. On the other hand, in the relaxed posture, in the mixed range of the fu-fu region and the het-heet region, the direction changes along the vertical axis with respect to the initial position, and it is a change in the tension direction, not the relaxation direction. In the relaxed position, this test subject endured something, indicating that the unrelaxed state continued for 40 to 50 minutes.

  FIG. 33 shows the results of sensory evaluation performed before and after measurement in the awakening induction posture and the relaxed posture. In the sensory evaluation, the awakening induction posture changes in the relaxation direction, but the relaxation posture changes in the reverse direction, which is consistent with the change determined from the measurement result of FIG.

(Test Example 4)
36 to 46 are data of male subjects in their twenties in the same manner as Test Example 3. Among these, FIG. 36 and FIG. 37 are data at the time of the onset of influenza, but this is the same data as FIG. 27 and FIG. Reprinted for ease of comparison. FIG. 38 and FIG. 39 are normal data measured in the awakening induction posture after the influenza was cured and the physical strength was sufficiently recovered (after 2 weeks from the measurement date of Test Example 3).

  FIG. 40A shows functional points obtained from the first determination reference point to which the zero cross detection unit of FIGS. 36 and 38 is applied by the state estimation unit 660, and FIG. 40B shows the state estimation unit. FIG. 40 is a diagram in which functional points obtained from a second determination reference point to which the peak detection unit of FIGS. 37 and 39 is applied are plotted in time series according to 660. The method of obtaining is the same as in Test Example 1.

  Looking at the results using the zero-cross detection means, at the time of the onset of influenza, as described in Test Example 3, the functional point gradually increases, and the sympathetic nerve is gradually activated. In normal times, the functional point is basically high, but suddenly drops in 50 minutes. In this regard, when looking at the data based on the other indices in FIG. 43, it can be seen that the transition from sleep to deep sleep occurs at about 50 minutes, but the sudden drop in the functional point in FIG. It can be estimated that this corresponds to this event. Accordingly, it can be set so that the state estimating means 660 determines that such a state change has occurred when the functional point has suddenly decreased more than a predetermined value. Whether or not it has shifted to deep sleep can also be understood from the fact that changes in head acceleration shown in FIGS. 44 to 46 are significantly smaller and more stable than others.

  The result of using the peak detection means of FIG. 40 (b) shows that the function of the parasympathetic nerve is gradually reduced at the time of the onset of influenza, and the sympathetic nerve is dominant. On the other hand, there is almost no change in the functional point in normal times. This is considered to be because the subject entered into a full-fledged sleep through the stages of light sleep, sleep, deep sleep during the test.

  In FIG. 41, the state estimation means 660 takes the index based on the first determination reference point on the horizontal axis (X axis) and the index based on the second determination reference point on the vertical axis (Y axis). It is the figure which calculated | required the time-sequential change of the coordinate calculated | required from a reference point and a 2nd determination reference point. The method of obtaining was the same as in Test Example 1, and a coordinate time series change line was drawn in two states of “when influenza occurred” and “normally”.

  First, the main movement direction of the coordinate time series change line is because the two measurement time points are as large as two weeks, and the physical condition criteria (healthy, at the onset of influenza) are completely different. You cannot see changes in physical condition with direction.

  Therefore, looking at the coordinate time series change line individually, at the time of the onset of influenza, as shown above, it suddenly dropped almost vertically first, showing signs of discomfort, and then went into sleep, but the resistance / resistance region It changes from the (hefty region) to the tolerance / adaptation region (Yuyu region), and it can be seen that the basic physical condition is unwell.

  On the other hand, in the normal state, the first half is decreasing at a slope close to 1 / f and is upward after 50 minutes. In other words, the features of the hatsutsu area gradually increase in the yuyu area, and the quality is high. It shows that physical strength recovered early by sleep.

  43, among the indicators shown in FIG. 43, in particular, the state is determined from the distribution ratios of three signals of 0.0017 Hz, 0.0035 Hz, and 0.0053 Hz previously proposed by the applicant as Japanese Patent Application No. 2010-244832. Looking at the figure based on the determination method, there is a portion showing a change in which the distribution rate of 0.0017 Hz rapidly decreases and the distribution rate of 0.053 Hz rapidly increases. This part is a signal indicating a sudden change in state, and is seen from 22 to 25 minutes, just before the sleep point, around 45 minutes. Of these, the signal immediately before the sleep point was defined as the “immediate sleep phenomenon” in the sense of the signal that the timing of entering sleep immediately was imminent. And since the signal of 22 to 25 minutes that occurred before that was a signal that predicted that the “imminent sleep phenomenon” immediately before falling asleep would appear, it was defined as the “imminent sleep sign phenomenon”. Moreover, about 45 minutes is considered to be a transition signal to deep sleep as described above.

  In the fingertip plethysmogram slope time series signal of FIG. 43, the power value slope time series fluctuation and the age-related Lyapunov exponent slope time series fluctuation are between 5 minutes and 10 minutes and 10 minutes to 15 minutes, respectively. There is a region showing an antiphase. This is already known by the present applicant to recognize a signal indicating such a state as a sleep onset symptom phenomenon, and appears approximately 10 to 20 minutes before the sleep onset point. The time series signal of the fingertip plethysmogram can capture such a predictive sleep phenomenon, but it clearly identifies the phenomena that are closer to the sleep point ("immediate sleep phenomenon" and "immediate sleep predictor"). It was difficult to capture. However, as described above, characteristic signals indicating “imminent sleep phenomenon” and “imminent sleep sign phenomenon” are obtained by observing the time series change of the distribution ratio of three signals of 0.0017 Hz, 0.0035 Hz, and 0.0053 Hz. I understood that Not only that, but also after sleep, if the distribution rate at 0.0017 Hz drops sharply and the distribution rate at 0.053 Hz rises rapidly, a change in state (change from sleep to deep sleep) can be captured. all right.

  44 to 46, the time point at which a change in which the head sway increases or decreases compared with the longitudinal acceleration appears can be seen in FIG. It almost coincides with the time when the above events appear. Specifically, as collectively shown in FIG. 46, in the case of the sleep onset symptom phenomenon captured by the time series fluctuation of the fingertip volume pulse wave, the figure indicating head fluctuation is greatly disturbed. On the other hand, the imminent sleep symptom phenomenon captured by the APW distribution rate time-series signal has a smaller area of the head swaying figure and a smaller movement, and the imminent sleeping phenomenon increases the area of the figure again. Immediately thereafter, the area becomes smaller, and the area becomes extremely small at the time of transition to deep sleep around 45 minutes. From these facts, it can be seen that the phenomenon that can be determined by analyzing the fingertip volume pulse wave or the signal captured by the APW coincides with the phenomenon that can be estimated from the appearance change of head fluctuation.

(Test Example 5)
For a 40-year-old male subject under the same conditions as in Test Examples 2 and 3, a normal sitting position (awake-inducing posture (shown as “wake-up position” in the figure)) and a sitting position with the thigh and spinal column opened wide The biological signal (APW) was collected even in a relaxed posture (indicated as “sleeping posture” in the figure). 54 and 55 show the analysis results based on the electroencephalogram, fingertip plethysmogram, and heartbeat measured during the test. FIG. 54 shows the result of the awakening induced posture, and FIG. 55 shows the result of the relaxed posture. However, from these figures, all of the subjects fell into a light sleep during the test.

  (A) of FIGS. 47 to 50 is an analysis waveform at a measurement start of 4.8 to 19.8 min, (b) is an analysis waveform of 4.8 to 30 min, and (c) is 20.1-39. .9 min analysis waveform, (d) is 30 to 49.8 min analysis waveform, and (e) is 40.2 to 60 min analysis waveform. The scores described in each of the drawings (a) to (e) are the determination reference points obtained by the determination reference point calculation means 650. Moreover, (f) of each figure shows the calculated functional point.

(Wake-up posture (displayed as “wake-up posture” in the figure))
The first determination reference point using the zero-cross detection means is 7 points in FIG. 47 (a), 6 points in FIG. 47 (b), 6 points in FIG. 47 (c), 6 points in FIG. In 47 (e), it was 4 points. The second determination reference points using the peak detecting means are 8 points in FIG. 48 (a), 3 points in FIG. 48 (b), 3 points in FIG. 48 (c), 1 point in FIG. In 48 (e), it was 3 points.

(Relaxing posture (shown as “sleeping posture” in the figure))
The first determination reference points using the zero-cross detection means are 5 points in FIG. 49 (a), 4 points in FIG. 49 (b), 4 points in FIG. 49 (c), 4 points in FIG. In 49 (e), it was 4 points. The second determination reference points using the peak detecting means are 7 points in FIG. 50 (a), 3 points in FIG. 50 (b), 3 points in FIG. 50 (c), 6 points in FIG. In 50 (e), it was 4 points.

  51A shows functional points obtained from the first determination reference point to which the zero cross detection means of FIGS. 47 and 49 are applied by the state estimation means 660, and FIG. 51B shows the state estimation means. FIG. 52 is a diagram in which functional points obtained from a second determination reference point to which the peak detection unit of FIGS. 48 and 50 is applied by 660 are plotted in time series. The method of obtaining is the same as in Test Example 1.

  Looking at the results using the zero-cross detection means, it is considered that there is no significant change in the first determination reference point in the sense-guided awake posture, and the change is in the sleep state where the fluctuation of the sympathetic nerve is small. With the peak detection means, in the relaxed posture, the parasympathetic nerve increased until 50 minutes, and it was observed that the patient relaxed with sleep, but the remaining 10 minutes showed a decrease in functional points and went to sleep. This shows the appearance of fatigue. On the other hand, in the awakening induction posture, an increase in the functional point is recognized until 40 minutes, and then the functional point is increased again after a slight decrease. This is considered to be a state in which the function has been restored by sleep and has been relaxed.

  In FIG. 52, the state estimation unit 660 takes the index based on the first determination reference point on the horizontal axis (X axis) and the index based on the second determination reference point on the vertical axis (Y axis). It is the figure which calculated | required the time-sequential change of the coordinate calculated | required from a reference point and a 2nd determination reference point. The method of obtaining is the same as in Test Example 1, and the coordinate time-series change lines in two states of “wakefulness induction posture” and “relaxation posture” are drawn.

  As a result, the main movement direction of the coordinate time-series change line is generally along the vertical axis, and it can be estimated that the physical condition is good.

  On the other hand, when looking at the coordinate time series change line individually, of the two coordinate time series change lines, in the awakening guidance posture, it is a slope that rises to the right, and from the range that shows the characteristics of the hetoheto region in the Yuu region, It is close to the range showing the characteristics of the hearth region, and it can be seen that the function recovered after gradually relaxing by sleeping. On the other hand, in the relaxed posture, the range changes within the range indicating the characteristics of the heptoh region in the Yuu region, shows a sudden drop in fluctuations close to 1 / f after sleep, and then slightly decreases to 1 / f It ’s close. This indicates that although he slept, he did not get much fatigue. In other words, it can be said that this test subject was able to relax and sleep and recover its function in the awakening-induced posture, but was not able to relax so much in the relaxed posture and could not get tired.

(Test Example 6)
The biological signal measuring means 1 shown in FIG. 1 is laminated on the back side of the back of the product name “Twin Lumber” made by Delta Touring Co., Ltd., and attached to the driver's seat of the truck. And a biological signal (hereinafter, referred to as “heart swing wave” but sometimes abbreviated as “APW”) by swinging the ventricle and the aorta. The total number of subjects was 153.

  FIG. 56 is a diagram showing the distribution of functional points of each subject obtained by the state estimation unit 660 from the first determination reference point to which the zero cross detection unit is applied. The horizontal axis indicates the number of functional points, and the vertical axis indicates the number of people. The higher the score, the higher the adaptability, compatibility, and comfort, and the lower the score, the lower the adaptability, compatibility, and comfort, and the higher the degree of fatigue. Also, during each experiment, each subject's physical condition was self-reported in three categories: “good”, “normal” and “bad”. The number of people by physical condition as reported is also displayed.

  As a result, “good” subjects tend to have a high distribution rate in the high score range, “bad” subjects tend to have a high distribution rate in the low score range, and “normal” is distributed around 3 points. Was. The average score of subjects who self-reported “good” was 7.38 points, the average score of subjects who self-reported “normal” was 3.54 points, and the average score of subjects who self-reported “bad” was 1.92 points Met. Therefore, the score of the subject self-reported as “good” is higher, and the score of the subject self-reported as “bad” is lower. Therefore, the functional score obtained by the state estimation means 660 and the physical condition may show a positive correlation. Recognize.

  FIG. 57 is an analysis of FIG. 56 from another viewpoint, and shows a distribution diagram of the average value and standard deviation of the score of functional points for each subject. Here, subjects are divided into two groups, Group A (high adaptability group), Group B, and C (low adaptability group) according to the tendency. A driver determined to have a low adaptability has collapsed in the 1 / f fluctuation straight line, which is a basic factor when adapting to external fluctuations, resulting in large variations in scores. In other words, when avoiding danger, it is suggested that there is a possibility that the risk avoidance ability may vary due to being intimidated or dying without being able to respond in a relaxed and high concentration state. And, there are many examples of self-reported physical condition. However, since the driver who answered “not good” here is aware, there is a possibility that it can be dealt with carefully, but a driver who is not aware may make an error if something unexpected happens. Increases nature. There are drivers who need external control here.

  FIG. 58 is a diagram showing the proportion of subjects determined to be healthy, non-disease, and diseased by the state estimation means 660. FIG. The state estimation unit 660 refers to the shape score based on the number of break points indicating the branching phenomenon at the level of the first determination reference point to which the zero-cross detection unit is applied, sets a predetermined threshold value, and when the score exceeds a predetermined level “Healthy” was set as “disease” when the score was less than or equal to a predetermined score, and the score during that time was set as “not sick”. As shown in FIG. 58, the ratio determined as “healthy” was 41%, the ratio determined as “non-disease” was 42%, and the ratio determined as “disease” was 17%.

  FIG. 59 is a diagram showing the proportions determined as healthy, non-disease, and illness according to physical condition (good, normal, poor) by self-report. It is inferred that a driver who declares “normal” or “good” has a high probability of “not sick”, and a driver who declares “unwell” has a high probability of illness. It can be seen that the judgment corresponds to self-reporting.

  FIG. 60 is a diagram showing the rate of sudden change risk estimated by the state estimation means 660. FIG. As in Test Examples 1 to 4, the sudden change risk is determined by the state estimation unit 660 with the index based on the first determination reference point on the horizontal axis (X axis) and the index based on the second determination reference point vertically. For the axis (Y-axis), the determination was performed by determining the time series change of coordinates obtained from the first determination reference point and the second determination reference point. That is, the determination was made based on the movement direction of the coordinate time-series change line. In FIG. 60, the region with one star is a case where the main moving direction is estimated to be in good condition between the active / adaptive region and the tolerance / adaptive region, and the region with two stars is active in the main moving direction.・ It is a case where it is assumed that it is a normal state when it is between the resistance region and tolerance / adaptation region. The main movement direction of the three stars is the sudden change in physical condition between the resistance / resistance region and the active / adaptation region. This is a case where it is estimated that there is a possibility of a fear. As a result, it was estimated that 33% of subjects were in a state of abrupt change.

(Test Example 7)
Next, a description will be given of a method for mainly capturing changes in the sense of how a person feels and changes in the perceptual sensory organ. Here, using the data of Test Example 1, the state estimation means 660 performed the following processing. The results are shown in FIGS. 62 (c), 63 (c), 64 (c) and 65 (c). These figures take into consideration the results shown in FIG. 16 and the functional points obtained by frequency analysis of the zero cross detection means ((a) of FIGS. 62 to 65) and the peak detection means. It is shown using the amount of change (slope) of the graph obtained from the time-series waveform of the frequency variation ((b) of FIGS. 62 to 65).

  Here, the time series waveform of the frequency fluctuation is a time series waveform obtained by the above-described frequency calculation means 610, and movement calculation is performed to obtain an average value of the frequency for each predetermined time window set with a predetermined overlap time. The time series change of the average value of the frequency obtained for each time window is output as a frequency fluctuation time series waveform. It is calculated | required by the frequency fluctuation | variation calculation means performed by the frequency fluctuation | variation calculation procedure which is a computer program of the biological condition estimation apparatus of this invention. Since the time series waveform of frequency fluctuations by the peak detector is linked to the frequency fluctuation of the heart rate, the heart rate depends on whether the amount of change (slope) of the time series waveform of frequency fluctuations is increased, decreased, or stagnant. Easily determine whether the number is increasing, decreasing, or stagnant with high sensitivity, and more directly perceive the person feels at that time (because this perception reflects the increase or decrease in heart rate) It is an index that reflects it.

  Therefore, in Test Example 7, the state estimation unit 660 uses the function points obtained from the frequency analysis result by the zero-cross detection unit reflecting the appearance state of the sympathetic nerve and the time series waveform of the frequency fluctuation by the peak detection unit. The state estimation which considered the judgment result was performed. The calculation method will be described with reference to FIGS.

  61 uses data in the static state of Test Example 1. FIG. First, from FIG. 16, it is determined at which position the coordinate time-series change line in the static state is changing. Here, in the case of the right quadrant to which the “activity / adaptation region (hatsatsu region)” and the “resistance / adaptation region (development region)” belong, it is determined as “satisfactory side (positive side)” and “activity / resistance” In the case of the left quadrant to which the “region (Foo Fu region)” and the “resistance / resistance region (heft region)” belong, it is determined as “unsatisfied side (negative side)”. FIG. 16 is a coordinate time series change line obtained by using the frequency analysis result obtained from both the zero-cross detection means and the peak detection means, and a basic state change at the time of measurement according to the autonomic nerve activity appears. Yes. Therefore, the state change that can be determined from FIG. 16 is regarded as reference information, and the amount of change (slope) of the time-series waveform of the frequency fluctuation, which is an index that directly reflects the perception that the person feels at that time, is added. Create coordinates.

  Since the coordinate time series change line in the static state in FIG. 16 is shifted toward the dissatisfied side, the change on the dissatisfied side is the base. With this information, the quadrant that is the base of the activity of the person's autonomic nervous system is captured, and in the coordinate system of FIG. 61 (c), basically the change to the left quadrant. The functional points obtained by frequency analysis of the zero cross detection means are plotted on the horizontal axis, and the amount of change (slope) in the predetermined time width of the time series waveform of the frequency fluctuation obtained by the peak detection means is plotted on the vertical axis.

  First, with respect to the initial position, the vertical axis is set to zero, and from the frequency analysis using the zero cross detection means in the static state, the function point of the initial position—three points (see FIG. 61A) is represented by the coordinates in FIG. 61C. Plot into the system. Next, the functional point at 25 minutes ((5 to 20 min (4.8 to 19.8 min) vs. 5 to 25 min (5.1 to 24.9 min)) − 15 points is moved along the horizontal axis, and FIG. The amount of change (slope) of the time-series waveform of the frequency fluctuation obtained by the peak detecting means in (b) is determined, and the first 5 to 7 minutes from the start of measurement until the subject's state is stabilized to some extent is ignored. Then, in FIG. 61 (b), the slope has increased for about 5 minutes after 7 minutes. The approximate line A is obtained, and the approximate line A is found at the slope a (tan θ = 0.839) of the approximate line A. Multiply the time width by 240 seconds and divide by 100 to obtain a value of 2.014. Similarly, the approximate line B, the approximate line C, and the approximate line D are obtained up to 25 minutes and summed up. (Approximation line A: 2.014) + (Approximation line B: −5.187) + (Approximate line C: 6.277) + (Approximate line D: −7.797) = − 4.69 That is, the vertical axis direction at 25 minutes moves −4.69 scale from the initial position. As a result, the coordinates (-18, -4.69) of 25 minutes are obtained as shown in Fig. 61. Next, at 30 minutes, the function point is -1, and Fig. 61 (b) ), The inclination after 25 minutes corresponds to the inclination of the approximate line D and the inclination of the approximate line E, so that they are calculated to be −2.62. .62) is moved, and the coordinates (-19, -7.31) of 30 minutes are obtained, and when the coordinates are connected, the change line of the coordinates shown in Fig. 61 (c) is obtained. From c), according to the determination of this test example, it can be seen that the subject has changed to a depressed region of dissatisfaction.

In the result of FIG. 16, the state where the Fu-Fu area and the Hatsatsu area are mixed is changed to the state where the Hetoheto area and the Yuu-Yu area are mixed, but the mood actually perceived by the subject is more depressed. I understand that.
62 to 65 are the static states of FIG. 16, when traveling between “Otani SA and Yoshima PA”, when traveling between “Yoshima PA and Yamakoshi”, and when traveling between “Yamagoe and Ishizuchiyama SA”. Each corresponds.

  First, the static state of FIG. 62 is exactly the same as that used in the description of the determination method in FIG. 61, and is reprinted in accordance with the displays of FIGS. Details are as described in FIG.

  63 (a) to 63 (c) are analysis results when traveling between “Otani SA and Yoshima PA”, starting from the dissatisfied side, and relatively in the normal mood between depression and relaxation From the state of being calm, it can be seen that the degree of concentration gradually increases and has shifted slightly to the satisfaction side.

  FIGS. 64 (a) to (c) are analysis results during travel between “Yoshima PA and Yamakoshi”, and it can be seen that the feeling of irritation gradually increases from the dissatisfied side.

  65 (a) to 65 (c) are results when traveling between “Yamagoe and Ishizuchiyama SA”, and it is shown that a running experiment is being conducted while concentrating and relaxing, starting from the satisfaction side. Recognize.

  When these results are compared with the results of FIG. 16, all are in a substantially similar region, but the determination of Test Example 1 shows a tendency as a result of the integration information, and the determination of Test Example 7 changes. Since it shows a tendency, it is closer to the sensation felt by the subject, the subject's perception is more strongly reflected, and in determining the subjective mood of the person, the determination in Test Example 7 is more actual for the subject. It can be said that it is close to the sense. However, since FIG. 16 obtained by Test Example 1 reflects the state of the sympathetic nerve and the parasympathetic nerve by the same method, when obtaining objective information on the general state of the physical condition, the method of FIG. Can be said to be preferable.

  The present invention is not limited to the case where biological signal measuring means is disposed on a vehicle seat such as an automobile to estimate the state of occupant sleepiness, etc., but the biological signal measurement is performed on a chair, office chair, etc. It can also be applied to state estimation by arranging means. In addition, a biological signal measuring means is arranged on a bed such as a bed in a hospital or a nursing facility, a body surface pulse wave (APW) of the back is captured, and analyzed by the above-described biological signal measuring device to estimate a human state. It can also be applied to. Thereby, it is possible to easily grasp the health status of a sleeping person (especially a sick person or a person who needs care) from the screen displayed on the monitor of the display means. In addition to the APW of the back, the biological signal measuring means is also brought into contact with the chest and abdomen, the body surface pulse wave from the chest and abdomen is collected, and analyzed together with the APW of the back as described above, It can also be used for determination of diseases associated with changes in states occurring in various parts, determination of state changes related to likes / dislikes of the five senses, changes in bad feelings, and the like.

  Further, the present invention is not limited to humans, but a biological signal measuring means is brought into contact with the body surface of an animal such as a constant temperature animal, and fluctuations and heart rate variability of the collected biological signal can be detected in terms of physical condition, disease determination, and change in feelings. It can also be used for determination and the like.

DESCRIPTION OF SYMBOLS 1 Biosignal measuring means 10 3D solid knitted fabric 15 3D solid knitted fabric support member 15a Arrangement through-hole 16 Film 21, 22 Plate-like foam 30 Vibration sensor 100 Sheet 110 Seat back frame 120 Skin 60 60 Living body state estimation apparatus 610 Frequency calculation Means 620 Frequency gradient time series analysis calculation means 630 Frequency analysis means 640 Regression line calculation means 650 Determination reference point calculation means 660 State estimation means

Claims (28)

A biological state estimation device that estimates a biological state using a biological signal collected by a biological signal measuring means,
A frequency calculating means for obtaining a time series waveform of a frequency from a time series waveform of a biological signal at a predetermined measurement time obtained by the biological signal measuring means;
In the time-series waveform of the frequency of the biological signal obtained by the frequency calculation means, movement calculation is performed for obtaining a slope of the frequency for each predetermined time window set with a predetermined overlap time, and obtained for each time window. A frequency gradient time series analysis calculating means for outputting a time series change of the frequency gradient as a frequency gradient time series waveform;
Frequency analysis means for performing frequency analysis on a frequency slope time series waveform in a predetermined time range obtained from the frequency slope time series analysis calculation means, and outputting an analysis waveform indicating a relationship between power spectrum density and frequency for each predetermined time range;
For each analysis waveform output by the frequency analysis means, a regression line calculation means for obtaining a regression line for each predetermined period region;
Each regression line obtained for each periodic region is given a region score based on its slope, and based on a difference in power spectral density values between regression lines in adjacent frequency regions and a difference in slope between regression lines. The number of break points indicating the branching phenomenon in each regression line is obtained, a shape score based on the number of break points is assigned, and a determination reference point for each analysis waveform is obtained using at least one of the region score and the shape score. A determination reference point calculating means;
A biological state estimation device comprising: state estimation means for estimating a biological state based on a time-series change of the determination reference points of each analysis waveform obtained by the determination reference point calculation means.   The living body state estimation apparatus according to claim 1, wherein the regression line calculation means divides an analysis waveform to be analyzed into a long period region, a medium period region, and a short period region to obtain the regression line.   The living body state estimation device according to claim 2, wherein the regression line calculation means obtains the center of gravity of the analysis waveform set in each of the long period area, the middle period area, and the short period area as the center of the regression line.   The regression line calculation means obtains a regression line for each of the ULF region and the VLF region, with the center of the regression line as a boundary in the long period region, and obtains a regression line for the ULF region and a regression line for the VLF region. It is determined whether or not the product of each slope is equal to or less than a predetermined value. If the product is less than the predetermined value, the regression lines of the ULF region and the VLF region are adopted. The biological state estimation apparatus according to claim 2 or 3, wherein the regression line is used.   The determination reference point calculation means divides the slope of each regression line in each region into three as a substantially horizontal state, upward and downward as the region score, and the upward and downward cases with respect to the score in the substantially horizontal state as a reference The biological state estimating device according to claim 1, wherein the score is increased or decreased depending on the case.   The biological condition estimation device according to claim 1, wherein the determination reference point calculation unit is configured to give a higher score as the shape score, the smaller the number of break points.   The determination reference point calculation means calculates the number of break points between two regression lines in adjacent periodic regions and the difference between power spectral density values between two regression lines in adjacent periodic regions and between two regression lines in adjacent periodic regions. In any one of Claims 1-6, when the difference between the values of the power spectral density is within a predetermined range and the difference between the inclination angles of the two regression lines is equal to or greater than a predetermined angle set in advance, each is counted as a break point. The biological state estimation apparatus according to 1. The state estimation means calculates the following formula between the determination reference points of the analysis waveform in two time ranges before and after the comparison target:
Function point = Judgment reference point of the later time range + (Judgment reference point of the later time range-Judgment reference point of the previous time range) x n (where n is a correction coefficient)
The biological state estimation apparatus according to claim 1, wherein the functional points obtained by the step are obtained in a time series, and the state of the biological body is estimated from a time series change of the functional points.   The frequency calculation means includes a zero cross detection means for obtaining a time series waveform of a frequency using a zero cross point in the time series waveform of the biological signal, and a frequency time series waveform using a peak point of the time series waveform of the biological signal. The biological state estimation apparatus according to any one of claims 1 to 8, comprising at least one means of a peak detection means to be obtained. The state estimation means includes a first determination reference point obtained from a frequency time-series waveform using the zero-cross detection means, and a second determination reference point obtained from a frequency time-series waveform using the peak detection means. And
An index based on the first determination reference point is taken on one axis, an index based on the second determination reference point is taken on the other axis,
The living body state estimation apparatus according to claim 9, wherein a time series change of coordinates obtained from the first determination reference point and the second determination reference point is obtained to estimate the state of the living body.   The state estimation means determines that the coordinate time-series change line connecting the coordinates is a change tendency approximating the inclination of 1 / f, determines that it is comfortable, and changes in the vertical direction. The biological state estimation apparatus according to claim 10, wherein it is determined that the user feels uncomfortable.   The state estimation means includes an active / adaptive region for each quadrant of a coordinate system having an index based on the first determination reference point on one axis and an index based on the second determination reference point on the other axis. The coordinate time-series change line to be compared is divided into a plurality of coordinate time-series change lines obtained at different measurement times by dividing into an active / resistance region, a resistance / resistance region, and a resistance / adaptive region. The living body state estimation apparatus according to claim 11, further comprising means for estimating a physical condition based on an overall movement direction of the body. The overall main moving direction of the coordinate time series change line is:
If it is between the active / adapted region and the tolerance / adapted region, it is estimated that the physical condition is good,
When it is between the active / resistance region and the tolerance / adaptation region, it is assumed to be a normal state,
The living body state estimation apparatus according to claim 11, wherein the state is estimated to be in a state where there is a risk of sudden change in physical condition when between the resistance / resistance region and the activity / adaptive region. Furthermore, in the time-series waveform of the frequency using the peak detecting means, the movement calculation for obtaining the average value of the frequency for each predetermined time window set with the predetermined overlap time is performed, and the average value of the frequency obtained for each time window. A frequency fluctuation calculating means for outputting the time series change of as a frequency fluctuation time series waveform,
The state estimation means takes on one axis an index corresponding to the functional point obtained from the frequency time-series waveform using the zero-cross detection means, and the frequency fluctuation time-series waveform obtained by the frequency fluctuation calculation means. Take the index corresponding to the amount of change in a given time span on the other axis,
The biological state estimation apparatus according to claim 8, wherein a time-series change in coordinates obtained from the functional point and the amount of change is obtained, and a biological state relating to a sense is estimated. A computer program set in a biological state estimation device that estimates a biological state using a biological signal collected by a biological signal measuring means,
A frequency calculation procedure for obtaining a time series waveform of a frequency from a time series waveform of a biological signal at a predetermined measurement time obtained by the biological signal measuring means;
In the time-series waveform of the frequency of the biological signal obtained by the frequency calculation procedure, the movement calculation for obtaining the slope of the frequency is performed for each predetermined time window set with a predetermined overlap time, and is obtained for each time window. Frequency slope time series analysis calculation procedure for outputting the time series change of the frequency slope as a frequency slope time series waveform;
A frequency analysis procedure for performing frequency analysis of a frequency gradient time series waveform in a predetermined time range obtained from the frequency gradient time series analysis calculation procedure, and outputting an analysis waveform indicating a relationship between power spectrum density and frequency for each predetermined time range;
For each analysis waveform output by the frequency analysis procedure, a regression line calculation procedure for obtaining a regression line for each predetermined period region,
Each regression line obtained for each periodic region is given a region score based on its slope, and based on a difference in power spectral density values between regression lines in adjacent frequency regions and a difference in slope between regression lines. The number of break points indicating the branching phenomenon in each regression line is obtained, a shape score based on the number of break points is assigned, and a determination reference point for each analysis waveform is obtained using at least one of the region score and the shape score. Judgment reference point calculation procedure,
A computer program for causing a computer to execute a state estimation procedure for estimating a state of a living body based on a time-series change of a determination reference point of each analysis waveform obtained by the determination reference point calculation procedure.   16. The computer program according to claim 15, wherein the regression line calculation procedure divides an analysis waveform to be analyzed into a long period area, a middle period area, and a short period area to obtain the regression line.   The computer program according to claim 16, wherein the regression line calculation procedure obtains a center of gravity of the analysis waveform set in each of the long period area, the middle period area, and the short period area as a center of the regression line.   In the regression line calculation procedure, in the long period region, the regression line is further divided into a ULF region and a VLF region with the center of the regression line as a boundary, and a regression line in the ULF region and a regression line in the VLF region are obtained. It is determined whether or not the product of each slope is equal to or less than a predetermined value. If the product is less than the predetermined value, the regression lines of the ULF region and the VLF region are adopted. The computer program according to claim 16 or 17, which employs the regression line.   In the determination reference point calculation procedure, as the area score, the slope of each regression line in each area is divided into three, roughly horizontal state, upward and downward, and the upward and downward cases are based on the score of the substantially horizontal state. The computer program according to any one of claims 15 to 18, wherein the score is increased or decreased in the case of.   The computer program according to any one of claims 15 to 19, wherein the determination reference point calculation procedure gives a higher score as the shape score as the number of breakage points is smaller.   In the determination reference point calculation procedure, the number of break points is calculated between two regression lines in adjacent periodic regions, and when the difference in the value of power spectral density is not less than a predetermined value, and between two regression lines in adjacent periodic regions. 21. The method according to any one of claims 15 to 20, wherein when the difference between the values of the power spectral density is within a predetermined range and the difference between the inclination angles of the two regression lines is equal to or greater than a predetermined angle, each is counted as a break point. The computer program according to 1. The state estimation procedure is performed between the determination reference points of the analysis waveform in the two time ranges before and after the comparison target:
Function point = Judgment reference point of the later time range + (Judgment reference point of the later time range-Judgment reference point of the previous time range) x n (where n is a correction coefficient)
The computer program according to any one of claims 15 to 21, wherein the functional point obtained by the step is obtained in time series, and the state of the living body is estimated from the time series change of the functional point.   The frequency calculation procedure includes a zero cross detection procedure for obtaining a time series waveform of a frequency using a zero cross point in a time series waveform of the biological signal, and a time series waveform of a frequency using a peak point of the time series waveform of the biological signal. The computer program according to any one of claims 15 to 22, comprising at least one of a desired peak detection procedure. The state estimation procedure includes a first determination reference point obtained from a frequency time-series waveform using the zero-cross detection procedure, and a second determination reference point obtained from a frequency time-series waveform using the peak detection procedure. And
An index based on the first determination reference point is taken on one axis, an index based on the second determination reference point is taken on the other axis,
24. The computer program according to claim 23, wherein a time series change in coordinates obtained from the first determination reference point and the second determination reference point is obtained to estimate the state of the living body.   The state estimation procedure determines that the coordinate time-series change line connecting the coordinates is a change tendency approximating to a 1 / f slope, and determines that it is comfortable and changes vertically. 25. The computer program according to claim 24, wherein the computer program is determined to be uncomfortable when it is determined.   The state estimation procedure includes an active / adaptive region in each quadrant of a coordinate system having an index based on the first determination reference point on one axis and an index based on the second determination reference point on the other axis. The coordinate time-series change line to be compared is divided into a plurality of coordinate time-series change lines obtained at different measurement times by dividing into an active / resistance region, a resistance / resistance region, and a resistance / adaptive region. 26. The computer program according to claim 25, wherein the physical condition is estimated based on the overall movement direction of. The overall main moving direction of the coordinate time series change line is:
If it is between the active / adapted region and the tolerance / adapted region, it is estimated that the physical condition is good,
When it is between the active / resistance region and the tolerance / adaptation region, it is assumed to be a normal state,
26. The computer program according to claim 25, wherein the computer program estimates that there is a risk of sudden change in physical condition when the region is between the tolerance / resistance region and the active / adaptation region. Furthermore, in the time-series waveform of the frequency using the peak detection procedure, movement calculation is performed to obtain the average value of the frequency for each predetermined time window set with the predetermined overlap time, and the average value of the frequency obtained for each time window A frequency variation calculation procedure for outputting a time-series change of as a frequency variation time-series waveform,
In the state estimation procedure, an index corresponding to the functional point obtained from the time series waveform of the frequency using the zero cross detection procedure is taken on one axis, and the frequency fluctuation time series waveform obtained by the frequency variation calculation procedure is taken. Take the index corresponding to the amount of change in a given time span on the other axis,
24. The computer program according to claim 23, wherein a time series change of coordinates obtained from the functional point and the amount of change is obtained to estimate a state of a living body related to a sense.