JP2012135499A - Blood purification system - Google Patents

Blood purification system Download PDF

Info

Publication number
JP2012135499A
JP2012135499A JP2010290812A JP2010290812A JP2012135499A JP 2012135499 A JP2012135499 A JP 2012135499A JP 2010290812 A JP2010290812 A JP 2010290812A JP 2010290812 A JP2010290812 A JP 2010290812A JP 2012135499 A JP2012135499 A JP 2012135499A
Authority
JP
Japan
Prior art keywords
blood
liquid
storage container
flow rate
pump
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010290812A
Other languages
Japanese (ja)
Other versions
JP5731190B2 (en
Inventor
Hironari Gotanda
裕也 五反田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Medical Co Ltd
Original Assignee
Asahi Kasei Medical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Medical Co Ltd filed Critical Asahi Kasei Medical Co Ltd
Priority to JP2010290812A priority Critical patent/JP5731190B2/en
Publication of JP2012135499A publication Critical patent/JP2012135499A/en
Application granted granted Critical
Publication of JP5731190B2 publication Critical patent/JP5731190B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Landscapes

  • External Artificial Organs (AREA)

Abstract

PROBLEM TO BE SOLVED: To provide a blood purification system for simply and appropriately preventing free flow in a transfusion line.SOLUTION: The blood purification system 1 has: a blood purifier 10; a blood circuit 13; a blood pump 14 for sending the blood; a liquid storage container 15; a transfusion line 16; a transfusion pump 18; a flow rate abnormality detection device 19 for detecting abnormality in liquid flow rate from the liquid storage container 15 to the blood tubing 13; and a controller 20 for stopping solution sending of the blood pump 14 and the transfusion pump 18 when the flow rate abnormality detection device 19 detects abnormality in solution sending flow rate. The liquid storage container 15 is provided at a position where head pressure of chemical liquid is lower than a patient's blood pressure. On the transfusion line 16, a check valve 17 for preventing flow of the liquid to the liquid storage container 15 side is provided.

Description

本発明は、血液浄化システムに関する。   The present invention relates to a blood purification system.

一般的に、血液浄化療法で用いられる血液浄化システムは、血液浄化器と、一端が患者に接続され他端が血液浄化器の入口に接続される動脈ラインと、一端が血液浄化器の出口に接続され他端が患者に接続される静脈ラインと、動脈ライン上にあり血液を血液浄化器に送液する血液ポンプを主に備えている。また、血液浄化システムは、上記構成に加えて、例えば液体貯留容器と、液体貯留容器から動脈ライン上の血液ポンプの上流側に抗凝固液などの薬液を供給する輸液ラインと、輸液ラインのチューブを押圧しながら扱いて送液する輸液ポンプを備えることがある。この場合、血液浄化処理中に、液体貯留容器の薬液が輸液ラインを通じて動脈ラインに注入され、患者に薬液が投与される。   In general, a blood purification system used in blood purification therapy includes a blood purification device, an arterial line having one end connected to the patient and the other end connected to the inlet of the blood purification device, and one end connected to the outlet of the blood purification device. It is mainly provided with a venous line connected to the patient at the other end and a blood pump on the arterial line for feeding blood to the blood purifier. In addition to the above configuration, the blood purification system includes, for example, a liquid storage container, an infusion line for supplying a chemical solution such as anticoagulant from the liquid storage container to the upstream side of the blood pump on the arterial line, and a tube of the infusion line There may be provided an infusion pump for handling and feeding while pressing. In this case, during the blood purification process, the drug solution in the liquid storage container is injected into the artery line through the infusion line, and the drug solution is administered to the patient.

しかしながら、上記輸液を行う血液浄化システムには、次のようないわゆるフリーフローの問題がある。   However, the blood purification system that performs the above infusion has the following so-called free flow problem.

フリーフローは、輸液ポンプから輸液ラインのチューブが離脱し、チューブが輸液ポンプの押圧力から開放されて、チューブ内が開放状態となり、液体貯留容器内の薬液がチューブを通じて動脈ラインに流れ込むこと、または、何らかの原因で輸液ポンプのチューブへの押圧力が低下して、チューブ内を閉鎖できなくなり、液体貯留容器の薬液がチューブを通じて動脈ラインに流れ込むことによって生じる。かかるフリーフローが生じると、薬液の流量が制御できないので、不適正な量の薬液が患者に投与されてしまう。   In the free flow, the tube of the infusion line is detached from the infusion pump, the tube is released from the pressing force of the infusion pump, the inside of the tube is opened, and the drug solution in the liquid storage container flows into the arterial line through the tube, or For some reason, the pressure applied to the tube of the infusion pump is lowered, the inside of the tube cannot be closed, and the liquid medicine in the liquid storage container flows into the artery line through the tube. When such a free flow occurs, the flow rate of the chemical solution cannot be controlled, so that an inappropriate amount of the chemical solution is administered to the patient.

そこで、上述のフリーフローを防止するためのいくつかの方法が提案されている。例えば、特許文献１には、チューブの液に輸液ポンプの駆動力が作用した場合にのみ開放状態となる弁を輸液ライン上に配置することが開示されている。特許文献２には、輸液ポンプから輸液ラインが離脱した場合に閉塞するクランプを有する輸液ラインと専用輸液ポンプが開示されている。   Therefore, several methods for preventing the above-described free flow have been proposed. For example, Patent Document 1 discloses disposing a valve on an infusion line that is opened only when a driving force of an infusion pump is applied to the liquid in the tube. Patent Document 2 discloses an infusion line having a clamp that is closed when the infusion line is detached from the infusion pump and a dedicated infusion pump.

特開２００５−２９６１４２号公報JP 2005-296142 A 特開２００９−１１９１６１号公報JP 2009-119161 A

しかしながら、特許文献１に記載された、チューブの液に輸液ポンプの駆動力が作用した場合にのみ開放状態となる弁は、特殊な構造を有し高価になるため一般的な使用には向かない。更には、動脈ラインの血液ポンプ等により弁の下流側が陰圧になる場合に、弁が開放状態となる可能性があるためフリーフローを防止できない。特許文献２に記載された発明では、余分なクランプと専用輸液ポンプが必要となり、高価になる。また、輸液ポンプから輸液ラインのチューブが離脱した場合のフリーフローは防止できるが、チューブが輸液ポンプから離脱せず、チューブへの押圧力が低下した場合のフリーフローは防止できない。   However, the valve described in Patent Document 1 that is opened only when the driving force of the infusion pump acts on the liquid in the tube is not suitable for general use because it has a special structure and is expensive. . Furthermore, when the downstream side of the valve becomes negative pressure due to a blood pump or the like in the arterial line, the valve may be in an open state, so that free flow cannot be prevented. In the invention described in Patent Document 2, an extra clamp and a dedicated infusion pump are required, which is expensive. In addition, free flow can be prevented when the tube of the infusion line is detached from the infusion pump, but free flow cannot be prevented when the tube is not detached from the infusion pump and the pressing force on the tube is reduced.

本発明は、上記従来技術の問題に鑑みてなされたものであり、上記輸液ラインにおけるフリーフローを簡単かつ適正に防止する血液浄化システムを提供することを目的とする。   The present invention has been made in view of the above problems of the prior art, and an object of the present invention is to provide a blood purification system that easily and appropriately prevents free flow in the infusion line.

上記目的を達成する本発明は、血液浄化器と、採血部から前記血液浄化器に患者の血液を供給し、当該血液浄化器から返血部に血液を戻すための血液回路と、前記血液回路上に設けられ、血液を送液する血液ポンプと、輸液用の液体を貯留する液体貯留容器と、一端が前記液体貯留容器に接続され、他端が前記血液回路に接続された輸液ラインと、前記輸液ライン上に設けられ、前記液体貯留容器内の液体を前記血液回路に送液する輸液ポンプと、前記液体貯留容器から前記血液回路への送液流量の異常を検知する流量異常検知装置と、前記流量異常検知装置が送液流量の異常を検知したときに、前記血液ポンプと前記輸液ポンプの送液を停止させる制御装置と、を有し、前記液体貯留容器は、前記液体の落差圧が患者血圧よりも低くなるような位置に設けられ、前記輸液ライン上には、前記液体貯留容器側への液体の流れを防止する逆止弁が設けられている。   To achieve the above object, the present invention provides a blood purifier, a blood circuit for supplying patient blood from a blood collection unit to the blood purifier, and returning blood from the blood purifier to the blood return unit, and the blood circuit. A blood pump for delivering blood; a liquid storage container for storing a liquid for infusion; an infusion line having one end connected to the liquid storage container and the other end connected to the blood circuit; An infusion pump which is provided on the infusion line and sends the liquid in the liquid storage container to the blood circuit; and a flow rate abnormality detection device which detects an abnormality in the flow rate of the liquid from the liquid storage container to the blood circuit; A control device for stopping the liquid pump and the infusion pump when the abnormal flow rate detection device detects an abnormal flow rate, and the liquid storage container has a drop pressure of the liquid. Will be lower than the patient's blood pressure Provided Do position, wherein the on infusion line, the check valve is provided for preventing the flow of liquid into the liquid storage container side.

本発明によれば、流量異常検知装置により液体貯留容器から血液回路への送液流量の異常を検知したときに、血液ポンプと輸液ポンプによる送液が停止される。そして、液体貯留容器は、液体の落差圧が患者血圧よりも低くなるような位置に設けられているので、送液が停止されても液体貯留容器の液体が輸液ラインを通じて血液回路内に流入しさらに患者に流入することを防止できる。さらに、輸液ライン上に逆止弁が設けられているので、液体貯留容器の液体の落差圧が低くても、血液回路の血液が輸液ライン側に逆流することを防止できる。よって、輸液ラインにおけるフリーフローを簡単かつ適正に防止できる。   According to the present invention, when an abnormality in the liquid flow rate from the liquid storage container to the blood circuit is detected by the flow rate abnormality detection device, the liquid feeding by the blood pump and the infusion pump is stopped. Since the liquid storage container is provided at a position where the drop pressure of the liquid is lower than the patient blood pressure, the liquid in the liquid storage container flows into the blood circuit through the infusion line even if the liquid feeding is stopped. Furthermore, it can prevent flowing into a patient. Furthermore, since the check valve is provided on the infusion line, the blood in the blood circuit can be prevented from flowing back to the infusion line side even if the liquid drop pressure in the liquid storage container is low. Therefore, the free flow in the infusion line can be prevented easily and appropriately.

前記流量異常検知装置は、前記液体貯留容器の重量を測定し、その重量変化から送液流量の異常を検知するようにしてもよい。   The flow rate abnormality detection device may measure the weight of the liquid storage container and detect an abnormality in the liquid supply flow rate from a change in the weight.

前記血液回路は、一端が前記採血部に接続され、他端が前記血液浄化器に接続された動脈ラインを有し、前記血液ポンプは、前記動脈ライン上に設けられ、前記輸液ラインは、前記動脈ラインの前記血液ポンプよりも上流に接続されていてもよい。   The blood circuit has an arterial line having one end connected to the blood collection unit and the other end connected to the blood purifier, the blood pump is provided on the arterial line, and the infusion line is the It may be connected upstream of the blood pump in the arterial line.

本発明によれば、輸液ラインにおけるフリーフローの発生を簡単かつ適正に防止し、更には、輸液ラインへの血液の逆流を防止できる。   ADVANTAGE OF THE INVENTION According to this invention, generation | occurrence | production of the free flow in an infusion line can be prevented simply and appropriately, and also the backflow of the blood to an infusion line can be prevented.

血液浄化システムの構成の概略を示す説明図である。It is explanatory drawing which shows the outline of a structure of the blood purification system.

以下、図面を参照して、本発明の好ましい実施の形態について説明する。図１は、本実施の形態に係る血液浄化システム１の構成の概略を示す説明図である。   Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings. FIG. 1 is an explanatory diagram showing an outline of a configuration of a blood purification system 1 according to the present embodiment.

図１に示すように血液浄化システム１は、血液を浄化する血液浄化器１０と、採血穿刺部１１から血液浄化器１０に血液を供給し、当該血液浄化器１０から返血穿刺部１２に血液を戻すための血液回路１３と、血液回路１３上に設けられた血液ポンプ１４と、輸液用の薬液を貯留する液体貯留容器１５と、輸液ライン１６と、輸液ライン１６上に設けられた逆止弁１７と、輸液ライン１６上に設けられた輸液ポンプ１８と、液体貯留容器１５から血液回路１３への送液流量の異常を検知する流量異常検知装置１９と、制御装置２０等を有している。   As shown in FIG. 1, a blood purification system 1 supplies blood to a blood purification device 10 from a blood purification device 10 that purifies blood and a blood collection puncture unit 11, and blood from the blood purification device 10 to a blood return puncture unit 12. A blood circuit 13 for returning the blood, a blood pump 14 provided on the blood circuit 13, a liquid storage container 15 for storing a medical solution for infusion, an infusion line 16, and a check provided on the infusion line 16. A valve 17, an infusion pump 18 provided on the infusion line 16, a flow rate abnormality detection device 19 that detects an abnormality in the flow rate of the liquid flow from the liquid storage container 15 to the blood circuit 13, a control device 20, and the like. Yes.

血液浄化器１０は、例えば中空糸膜により血液を浄化できる。血液回路１３は、一端が採血穿刺部１１に接続され、他端が血液浄化器１０の入口に接続された動脈ライン３０と、一端が血液浄化器１０の出口に接続され、他端が返血穿刺部１２に接続された静脈ライン３１を有している。血液回路１３は、軟質のチューブにより構成されている。   The blood purifier 10 can purify blood using, for example, a hollow fiber membrane. The blood circuit 13 has one end connected to the blood collection puncture unit 11 and the other end connected to the inlet of the blood purifier 10, one end connected to the outlet of the blood purifier 10, and the other end returning blood. It has a vein line 31 connected to the puncture unit 12. The blood circuit 13 is composed of a soft tube.

血液ポンプ１４は、例えば動脈ライン３０に設けられている。血液ポンプ１４は、例えばチューブポンプであり、血液回路１３のチューブを押圧しながら扱くことによりチューブ内の血液を圧送できる。   The blood pump 14 is provided in the arterial line 30, for example. The blood pump 14 is, for example, a tube pump, and can pump blood in the tube by handling the tube of the blood circuit 13 while pressing it.

輸液ライン１６は、一端が動脈ライン３０の血液ポンプ１４よりも上流に接続され、他端が液体貯留容器１５に接続されている。輸液ライン１６は、軟質のチューブにより構成されている。   One end of the infusion line 16 is connected upstream of the blood pump 14 in the arterial line 30 and the other end is connected to the liquid storage container 15. The infusion line 16 is composed of a soft tube.

液体貯留容器１５には、抗凝固液などの輸液用の薬液が貯留されている。液体貯留容器１５は、薬液の落差圧が患者血圧よりも低くなるような位置に設置されている。例えば一般的に健常人の最低血圧変動範囲は、７５〜８９mmHgであり、液体貯留容器１５は、この一般的な血圧変動範囲よりも十分に低い落差圧になる位置に設置される。なお、患者毎に血圧を測定し、その測定結果に基づいて液体貯留容器１５の設置位置を選択してもよい。
また、薬液の落差圧が患者血圧よりも低くなる位置に液体貯留容器１５を設置するために、液体貯留容器１５を採血穿刺部１１よりも低い位置に設置してもよい。これは、採血穿刺部１１では、血液の圧力が陽圧であるため、液体貯留容器１５が採血穿刺部１１より低くければ、液体貯留容器１５側が必ず陰圧になることによる。なお、輸液ライン１６が血液回路１３の血液ポンプ１４よりも下流側に接続されている場合には、薬液の落差圧が患者血圧よりも低くなる位置に液体貯留容器１５を設置するために、液体貯留容器１５を返血穿刺部１２よりも低い位置に設置してもよい。さらに、薬液の落差圧が患者血圧よりも低くなる位置に液体貯留容器１５を設置するために、液体貯留容器１５を採血穿刺部１１と返血穿刺部１２の両方よりも低い位置に設置しておいてもよい。 The liquid storage container 15 stores an infusion chemical solution such as an anticoagulant solution. The liquid storage container 15 is installed at a position where the drop pressure of the chemical solution is lower than the patient blood pressure. For example, generally, the minimum blood pressure fluctuation range of a healthy person is 75 to 89 mmHg, and the liquid storage container 15 is installed at a position where a drop pressure is sufficiently lower than the general blood pressure fluctuation range. The blood pressure may be measured for each patient, and the installation position of the liquid storage container 15 may be selected based on the measurement result.
Further, the liquid storage container 15 may be installed at a position lower than the blood collection puncture unit 11 in order to install the liquid storage container 15 at a position where the drop pressure of the drug solution is lower than the patient blood pressure. This is because the blood pressure at the blood collection puncture unit 11 is positive, so if the liquid storage container 15 is lower than the blood collection puncture unit 11, the liquid storage container 15 side will always have a negative pressure. When the infusion line 16 is connected to the downstream side of the blood pump 14 of the blood circuit 13, the liquid storage container 15 is placed at a position where the drop pressure of the liquid medicine is lower than the patient blood pressure. The storage container 15 may be installed at a position lower than the blood return puncture unit 12. Further, in order to install the liquid storage container 15 at a position where the drop pressure of the liquid medicine is lower than the patient blood pressure, the liquid storage container 15 is installed at a position lower than both the blood collection puncture unit 11 and the blood return puncture unit 12. It may be left.

逆止弁１７は、輸液ライン１６上において血液回路１３から液体貯留容器１５側への液体の流れを防止できる。   The check valve 17 can prevent the flow of liquid from the blood circuit 13 to the liquid storage container 15 side on the infusion line 16.

輸液ポンプ１８は、例えばチューブポンプであり、輸液ライン１６のチューブを押圧しながら扱くことによりチューブ内の薬液を血液回路１３に圧送できる。   The infusion pump 18 is, for example, a tube pump, and can feed the drug solution in the tube to the blood circuit 13 by handling the infusion line 16 while pressing the tube.

流量異常検知装置１９は、例えば液体貯留容器１５の重量を測定する重量計を有している。流量異常検知装置１９は、例えば重量計の測定重量から送液流量を算出し、当該測定送液流量と、予め設定されている輸液ポンプ１８に対する設定送液流量とを比較し、その差が閾値を超えた場合に異常と判定する。   The flow rate abnormality detection device 19 has, for example, a weigh scale that measures the weight of the liquid storage container 15. For example, the flow rate abnormality detection device 19 calculates a liquid feeding flow rate from a measured weight of a weigh scale, compares the measured liquid feeding flow rate with a preset liquid feeding flow rate for the infusion pump 18, and the difference is a threshold value. If it exceeds, it is determined as abnormal.

流量異常検知装置１９により検知された送液流量の異常情報は、制御装置２０に出力される。制御装置２０は、当該異常情報に基づいて、血液ポンプ１４と輸液ポンプ１８の送液を停止させる。制御装置２０は、例えば汎用のコンピュータであり、記憶部、演算部、表示部等を有し、記憶部に記憶されているプログラムを演算部で実行することにより上記動作を行うことができる。   The abnormality information of the liquid feeding flow rate detected by the flow rate abnormality detection device 19 is output to the control device 20. The control device 20 stops the liquid feeding of the blood pump 14 and the infusion pump 18 based on the abnormality information. The control device 20 is, for example, a general-purpose computer, and includes a storage unit, a calculation unit, a display unit, and the like, and can perform the above-described operation by executing a program stored in the storage unit using the calculation unit.

次に、上記血液浄化システム１の動作について説明する。先ず、血液浄化処理が行われる際には、血液ポンプ１４が作動し、患者１００の血液が動脈ライン３０を通じて血液浄化器１０に送られ、当該血液浄化器１０で浄化された血液が静脈ライン３１を通じて患者１００に戻される。また血液浄化処理中、輸液ポンプ１８が作動し、液体貯留容器１５の薬液が所定の設定流量で輸液ライン１６を通じて動脈ライン３０に送られる。   Next, the operation of the blood purification system 1 will be described. First, when the blood purification process is performed, the blood pump 14 is activated, the blood of the patient 100 is sent to the blood purification device 10 through the arterial line 30, and the blood purified by the blood purification device 10 is the venous line 31. To the patient 100. During the blood purification process, the infusion pump 18 is operated, and the chemical solution in the liquid storage container 15 is sent to the arterial line 30 through the infusion line 16 at a predetermined set flow rate.

この際、流量異常検知装置１９により液体貯留容器１５における薬液の送液流量が監視されている。仮に輸液ライン１６のチューブが輸液ポンプ１８から外れ、又は輸液ポンプ１８のチューブへの押圧力が低下して、液体貯留容器１５における薬液の測定送液流量と輸液ポンプ１８の設定送液流量に閾値を超える差が生じた場合には、送液流量の異常が検出され、制御装置２０により、血液ポンプ１４と輸液ポンプ１８の送液が停止される。これにより、血液回路１３内の血液の流れと、輸液ライン１６の薬液の流れが停止する。   At this time, the flow rate of the chemical solution in the liquid storage container 15 is monitored by the flow rate abnormality detection device 19. If the tube of the infusion line 16 is disconnected from the infusion pump 18 or the pressing force to the tube of the infusion pump 18 is lowered, the measured liquid feed rate of the liquid solution in the liquid storage container 15 and the set liquid feed rate of the infusion pump 18 are threshold values. When a difference exceeding 1 is generated, an abnormality in the liquid feeding flow rate is detected, and the controller 20 stops the feeding of the blood pump 14 and the infusion pump 18. Thereby, the flow of the blood in the blood circuit 13 and the flow of the chemical solution in the infusion line 16 are stopped.

本実施の形態によれば、流量異常検知装置１９により液体貯留容器１５から血液回路１３への送液流量の異常を検知したときに、血液ポンプ１４と輸液ポンプ１８による送液が停止される。そして、液体貯留容器１５は、薬液の落差圧が、患者血圧（本実施の形態では、採血穿刺部１１の圧力）よりも低くなるような位置に配置されているので、送液が停止されても液体貯留容器１５の薬液が血液回路１３内に流入しさらに患者１００に流入することを防止できる。さらに、輸液ライン１６上に逆止弁１７が設けられているので、液体貯留容器１５の薬液の落差圧が低くても、血液回路１３の血液が輸液ライン１６側に逆流することを防止できる。よって、輸液ライン１６におけるフリーフローを簡単かつ適正に防止できる。   According to the present embodiment, when an abnormality in the flow rate of liquid flow from the liquid storage container 15 to the blood circuit 13 is detected by the flow rate abnormality detection device 19, the liquid supply by the blood pump 14 and the infusion pump 18 is stopped. And since the liquid storage container 15 is arrange | positioned in the position where the drop pressure of a chemical | medical solution becomes lower than a patient's blood pressure (the pressure of the blood collection puncture part 11 in this Embodiment), liquid feeding is stopped. In addition, the liquid medicine in the liquid storage container 15 can be prevented from flowing into the blood circuit 13 and further into the patient 100. Furthermore, since the check valve 17 is provided on the infusion line 16, it is possible to prevent the blood in the blood circuit 13 from flowing back to the infusion line 16 side even if the drop pressure of the liquid medicine in the liquid storage container 15 is low. Therefore, the free flow in the infusion line 16 can be prevented easily and appropriately.

また、本実施の形態では、流量異常検知装置１９が、液体貯留容器１５の重量を測定し、その重量変化から送液流量の異常を検知するものであるので、フリーフローの原因となる輸液ライン１６のチューブの輸液ポンプ１８からの離脱や、輸液ポンプ１８のチューブへの押圧力の低下が発生したときに生じる送液流量の異常を簡単かつ確実に検知できる。   Further, in the present embodiment, the flow rate abnormality detection device 19 measures the weight of the liquid storage container 15 and detects an abnormality in the liquid delivery flow rate from the change in the weight, so that the infusion line that causes the free flow It is possible to easily and reliably detect an abnormality in the flow rate of the liquid that occurs when the 16 tubes are detached from the infusion pump 18 or when the pressure of the infusion pump 18 on the tube is reduced.

本実施の形態では、輸液ライン１６が動脈ライン３０の血液ポンプ１４よりも上流に接続されている。この場合、一般的には、血液ポンプ１４により輸液ライン１６の接続部Ａにおける動脈ライン３０が陰圧になりやすく、輸液ライン１６のチューブの輸液ポンプ１８からの離脱や、輸液ポンプ１８のチューブへの押圧力の低下が生じた場合に、液体貯留容器１５の薬液が動脈ライン３０に流れ込みやすくなる。したがって、本実施の形態のように、液体貯留容器１５から血液回路１３への送液流量の異常を検知したときに血液ポンプ１４による送液を停止したり、また薬液の落差圧が輸液ライン１６との接続部Ａにおける血液回路１３の血液の圧力よりも低くなる位置に液体貯留容器１５を配置するメリットは大きい。   In the present embodiment, the infusion line 16 is connected upstream of the blood pump 14 in the arterial line 30. In this case, in general, the arterial line 30 at the connection portion A of the infusion line 16 is likely to be negatively pressured by the blood pump 14, and the tube of the infusion line 16 is detached from the infusion pump 18 or to the tube of the infusion pump 18. When the pressing force decreases, the chemical liquid in the liquid storage container 15 easily flows into the arterial line 30. Therefore, as in the present embodiment, when an abnormality in the flow rate of the liquid flow from the liquid storage container 15 to the blood circuit 13 is detected, the liquid feed by the blood pump 14 is stopped, or the drop pressure of the chemical solution is reduced by the infusion line 16. The merit of disposing the liquid storage container 15 at a position lower than the blood pressure of the blood circuit 13 in the connection portion A is great.

以上、添付図面を参照しながら本発明の好適な実施の形態について説明したが、本発明はかかる例に限定されない。当業者であれば、特許請求の範囲に記載された思想の範疇内において、各種の変更例または修正例に想到し得ることは明らかであり、それらについても当然に本発明の技術的範囲に属するものと了解される。   The preferred embodiments of the present invention have been described above with reference to the accompanying drawings, but the present invention is not limited to such examples. It is obvious for those skilled in the art that various modifications or modifications can be conceived within the scope of the idea described in the claims, and these naturally belong to the technical scope of the present invention. It is understood.

例えば以上の実施の形態で記載した液体貯留容器１５に貯留される輸液用の液体は、抗凝固液や補充液、透析液などが例として挙げられるが、特に限定されるものではない。また、液体の種類等によって血液回路１３に対する輸液ライン１６の接続位置も適宜変更できる。流量異常検出装置１９は、液体貯留容器１５の重量を測定するものに限られず、他の方法で送液流量の異常を検知するものであってもよい。送液流量の異常を検知する他の方法として、例えば容積計量式流量計を用いて、規定量の計量容器が一杯になるまでの時間から送液流量の異常を検知する方法、滴下センサを用いて、滴の容量が規定量となるように設計された点滴筒の滴下の数と滴下間隔から送液流量の異常を検知する方法、超音波流量計により送液流量の異常を検知する方法などがある。本発明は、血液透析に限られず、血液濾過処理、血漿交換処理等のあらゆる血液浄化処理を行う血液浄化システムに適用できる。   For example, examples of the infusion liquid stored in the liquid storage container 15 described in the above embodiment include an anticoagulant solution, a replenisher solution, and a dialysis solution, but are not particularly limited. In addition, the connection position of the infusion line 16 with respect to the blood circuit 13 can be changed as appropriate depending on the type of liquid. The flow rate abnormality detection device 19 is not limited to the device that measures the weight of the liquid storage container 15, and may be a device that detects an abnormality in the liquid supply flow rate by another method. As another method for detecting an abnormality in the liquid supply flow rate, for example, using a volumetric flow meter, a method for detecting an abnormality in the liquid supply flow rate from the time until the specified amount of the measuring container is full, a drop sensor is used. In addition, a method for detecting abnormalities in the flow rate of liquid from the number of drops and the interval between drops in a drip cylinder designed so that the volume of the drop is a specified amount, a method for detecting abnormalities in the flow rate of liquid using an ultrasonic flowmeter There is. The present invention is not limited to hemodialysis, and can be applied to a blood purification system that performs all blood purification processes such as blood filtration and plasma exchange.

１ 血液浄化システム
１０ 血液浄化器
１１ 採血穿刺部
１２ 返血穿刺部
１３ 血液回路
１４ 血液ポンプ
１５ 液体貯留容器
１６ 輸液ライン
１７ 逆止弁
１８ 輸液ポンプ
１９ 流量異常検知装置
２０ 制御装置
３０ 動脈ライン
３１ 静脈ライン
１００ 患者
Ａ 接続部 DESCRIPTION OF SYMBOLS 1 Blood purification system 10 Blood purifier 11 Blood collection puncture part 12 Blood return puncture part 13 Blood circuit 14 Blood pump 15 Liquid storage container 16 Infusion line 17 Check valve 18 Infusion pump 19 Flow rate abnormality detection apparatus 20 Control apparatus 30 Arterial line 31 Vein Line 100 Patient A connection

Claims (3)

血液浄化器と、
採血部から前記血液浄化器に患者の血液を供給し、当該血液浄化器から返血部に血液を戻すための血液回路と、
前記血液回路上に設けられ、血液を送液する血液ポンプと、
輸液用の液体を貯留する液体貯留容器と、
一端が前記液体貯留容器に接続され、他端が前記血液回路に接続された輸液ラインと、
前記輸液ライン上に設けられ、前記液体貯留容器内の液体を前記血液回路に送液する輸液ポンプと、
前記液体貯留容器から前記血液回路への送液流量の異常を検知する流量異常検知装置と、
前記流量異常検知装置が送液流量の異常を検知したときに、前記血液ポンプと前記輸液ポンプの送液を停止させる制御装置と、を有し、
前記液体貯留容器は、前記液体の落差圧が患者血圧よりも低くなるような位置に設けられ、
前記輸液ライン上には、前記液体貯留容器側への液体の流れを防止する逆止弁が設けられている、血液浄化システム。 A blood purifier,
A blood circuit for supplying the patient's blood from the blood collection unit to the blood purifier and returning the blood from the blood purifier to the blood return unit;
A blood pump provided on the blood circuit for feeding blood;
A liquid storage container for storing a liquid for infusion;
An infusion line having one end connected to the liquid reservoir and the other end connected to the blood circuit;
An infusion pump that is provided on the infusion line and that delivers the liquid in the liquid storage container to the blood circuit;
A flow rate abnormality detection device that detects an abnormality in the flow rate of the liquid from the liquid storage container to the blood circuit;
A control device for stopping the liquid pump and the infusion pump when the abnormal flow rate detection device detects an abnormal flow rate;
The liquid storage container is provided at a position where the drop pressure of the liquid is lower than the patient blood pressure,
A blood purification system, wherein a check valve is provided on the infusion line to prevent a liquid from flowing toward the liquid storage container. 前記流量異常検知装置は、前記液体貯留容器の重量を測定し、その重量変化から送液流量の異常を検知する、請求項１に記載の血液浄化システム。   The blood purification system according to claim 1, wherein the flow rate abnormality detection device measures the weight of the liquid storage container and detects an abnormality in the liquid delivery flow rate from a change in the weight. 前記血液回路は、一端が前記採血部に接続され、他端が前記血液浄化器に接続された動脈ラインを有し、
前記血液ポンプは、前記動脈ライン上に設けられ、
前記輸液ラインは、前記動脈ラインの前記血液ポンプよりも上流に接続されている、請求項１又は２に記載の血液浄化システム。 The blood circuit has an arterial line having one end connected to the blood collection unit and the other end connected to the blood purifier.
The blood pump is provided on the arterial line;
The blood purification system according to claim 1 or 2, wherein the infusion line is connected upstream of the blood pump of the arterial line.
JP2010290812A 2010-12-27 2010-12-27 Blood purification system Active JP5731190B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2010290812A JP5731190B2 (en) 2010-12-27 2010-12-27 Blood purification system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2010290812A JP5731190B2 (en) 2010-12-27 2010-12-27 Blood purification system

Publications (2)

Publication Number Publication Date
JP2012135499A true JP2012135499A (en) 2012-07-19
JP5731190B2 JP5731190B2 (en) 2015-06-10

Family

ID=46673464

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010290812A Active JP5731190B2 (en) 2010-12-27 2010-12-27 Blood purification system

Country Status (1)

Country Link
JP (1) JP5731190B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6189562B1 (en) * 2017-03-17 2017-08-30 株式会社熊本アイディーエム Treatment device

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6343547U (en) * 1986-09-08 1988-03-23
JPH06218046A (en) * 1993-01-25 1994-08-09 Sanyo Electric Works Ltd Blood purifier
JPH09620A (en) * 1995-06-16 1997-01-07 Asahi Medical Co Ltd Extracorporeal blood circulating and processing system for treatment of behcet's disease
JP2000107281A (en) * 1998-10-05 2000-04-18 Terumo Corp Roller pump and blood treating circuit
JP2004174235A (en) * 2002-11-14 2004-06-24 Nikkiso Co Ltd Blood purification apparatus
US20040133145A1 (en) * 2002-12-20 2004-07-08 Hospal International Marketing Management Snc Device and process for extracorporeal treatment by citrate anticoagulant
WO2007129463A2 (en) * 2006-04-26 2007-11-15 Nikkiso Co., Ltd. Biological component measuring equipment and method of calibration of biological component measuring equipment

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6343547U (en) * 1986-09-08 1988-03-23
JPH06218046A (en) * 1993-01-25 1994-08-09 Sanyo Electric Works Ltd Blood purifier
JPH09620A (en) * 1995-06-16 1997-01-07 Asahi Medical Co Ltd Extracorporeal blood circulating and processing system for treatment of behcet's disease
JP2000107281A (en) * 1998-10-05 2000-04-18 Terumo Corp Roller pump and blood treating circuit
JP2004174235A (en) * 2002-11-14 2004-06-24 Nikkiso Co Ltd Blood purification apparatus
US20040133145A1 (en) * 2002-12-20 2004-07-08 Hospal International Marketing Management Snc Device and process for extracorporeal treatment by citrate anticoagulant
WO2007129463A2 (en) * 2006-04-26 2007-11-15 Nikkiso Co., Ltd. Biological component measuring equipment and method of calibration of biological component measuring equipment

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6189562B1 (en) * 2017-03-17 2017-08-30 株式会社熊本アイディーエム Treatment device
JP2018153459A (en) * 2017-03-17 2018-10-04 株式会社熊本アイディーエム Treatment apparatus

Also Published As

Publication number Publication date
JP5731190B2 (en) 2015-06-10

Similar Documents

Publication Publication Date Title
US10973973B2 (en) Device and method for monitoring an extracorporeal blood treatment
EP2529771B1 (en) Detecting blood flow degradation
US7713226B2 (en) On demand and post-treatment delivery of saline to a dialysis patient
US8043076B2 (en) Method and device for operating an electric peristaltic hose pump
US9833561B2 (en) Occlusion detection in delivery of fluids
JP5125013B2 (en) Method for detecting occurrence of trouble causing poor blood removal and hemodialysis apparatus
US20190143015A1 (en) Medical Treatment Device And Hose Set For A Medical Treatment Device And Method For Monitoring A Peristaltic Hose Pump
US10328193B2 (en) Extracorporeal blood treatment apparatus with multiple treatment solution reservoirs
JP5731190B2 (en) Blood purification system
CN102872488B (en) Blood plasma purifying device and work method of the blood plasma purifying device
CN111870753A (en) Modular bedside blood purification equipment and control method thereof
JP4978179B2 (en) Blood purification equipment
EP2641625B1 (en) Extracorporeal blood treatment apparatus with multiple treatment solution reservoirs
JP2007236923A (en) Blood purification circuit
US12005175B2 (en) Blood purification device
US11806458B2 (en) Blood treatment device with automatic reduction of a substitution-solution flow rate
JP2012152287A (en) Blood purification device
WO2020136998A1 (en) Blood purification device
JP2012135498A (en) Infusion system and control method for the same
JP2023119235A (en) Blood purification device
CN114129799A (en) Blood purification system
AU2016341659A1 (en) Device, system, and method for the pressure-based detection of a clot

Legal Events

Date Code Title Description
A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20120416

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20131211

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20141003

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20141007

A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141204

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150407

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150409

R150 Certificate of patent or registration of utility model

Ref document number: 5731190

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350