JP2012120769A - Device and method for tablet administered as suspension - Google Patents

Abstract

PROBLEM TO BE SOLVED: To administer a suspended drug obtained by crushing a tablet in a closed system and suspending the crushed tablet in the closed system, to a patient in the closed system.SOLUTION: A device for tablet administered as a suspension includes: a tablet crushing syringe for crushing the tablet; a water supplying syringe for supplying water; and a T-shaped stopcock for connecting the tablet crushing syringe and the water supplying syringe. The tablet crushing syringe internally includes pins for crushing the tablet. The T-shaped stopcock includes three connecting ends internally having flow passages, and a sliding valve body for selecting and connecting two of the flow passages of the three connecting ends at a junction base portion of the three connecting ends. The end of the tablet crushing syringe and the end of the water supplying syringe are each connected to any of the connecting ends of the T-shaped stopcock.

Description

  The present invention comprises a tablet suspension administration device for suspending a tablet in water to form a suspension drug solution, and administering the suspension drug solution to a patient, and using this device to form the suspension drug solution, The present invention relates to a tablet suspension administration method for administering a suspension drug solution to a patient.

  In recent years, Japan has faced a full-fledged aging society, and the number of elderly people who require tube administration of drugs, such as nasogastric tube and gastrostoma administration, where drugs are administered to patients via tube tubes, is increasing. I'm following.

  In the case of nasogastric tube or gastrostoma administration when the drug to be administered is tablet, the tablet is pulverized into pulverized powder, and this is dissolved in white water and administered, and the tablet is heated to about 55 ° C. just before administration. Two methods, the Kurata-type simple suspension method, are used to disintegrate and suspend them.

  The simple suspension method is superior to the pulverization method in terms of the stability of the active ingredient and the certainty of drug administration. Currently, the tablet suspension by the simple suspension method is administered to patients by tube. The method of doing is becoming common.

  However, some anti-cancer agents that are unstable to heat still use a pulverization method in which tablets are crushed into pulverized powder and dissolved in white water.

  Many anticancer drugs used in cancer chemotherapy today have various risk factors such as mutagenicity, genotoxicity of chromosomal abnormalities, carcinogenicity, and fetal malformation. Currently, in tube administration of oral anticancer drugs, the pulverization method and the administration (nurse, caregiver) are always exposed to the risk of exposure by the scattered suspension method. ing.

  As the actual situation of exposure to anticancer drugs, a small amount of anticancer drug is detected from the urine of dispensers and nurses, and detection is also reported from places where the anticancer drug is not directly touched, such as door knobs and dispensing tables of hospital pharmacies. Yes.

  Therefore, at present, there is a concern about the risk of exposure to anticancer drugs not only for pharmacists involved in pulverized dispensing but also for all administration persons (nurses, caregivers, etc.) involved in administration of anticancer drugs.

  In addition, cyclophosphamide (CPA), which is one of the anticancer agents, volatilizes at room temperature, so that not only exposure due to pulverized preparation and drug suction scattered during administration, but also tube after tube administration, residual after suspension administration. Due to volatilization from liquids, equipment used, and patient's urine, there is a concern about the risk of anti-cancer drug contamination in all facilities (hospital, home, care facility, etc.) involving the patient.

  The International Agency for Research on Cancer (IARC), a division of the World Health Organization (WHO), classifies CPA carcinogenicity as the most dangerous group 1 and applies chemicals, including pharmaceuticals, to the human body. Data on exposure and carcinogenicity are compiled to classify risk levels.

  In this report, CPA is classified as equivalent to asbestos. In fact, there are reports of detection of CPA from the urine of medical staff handling anticancer drugs, and many cases of detection of anticancer drugs other than CPA have been reported.

  Currently, guidelines for the treatment of injections of antineoplastic drugs have been created worldwide for anticancer drugs as injections. In Japan, a revised version of the "In-Hospital Handling Guidelines for Anti-neoplastic Agents" has been published in Japan Hospital. Under the supervision of the Pharmacists Association, the “Anticancer Drug Preparation Manual” was published in 2006, and alerts have been made to healthcare professionals who handle injections of anticancer drugs.

  The “Preparation Manual for Anticancer Drugs” supervised by the Japan Hospital Pharmacists Association specifies preparation in a safety cabinet and requires measures to prevent exposure such as wearing the cap, mask, goggles, gown, and gloves of the preparer. It has been.

  On the other hand, in the preparation of pulverized preparations and suspensions of anticancer drugs, there is a risk similar to the preparation of injections. In addition to wearing masks and hats, it is only a statement that “protect gloves with gloves to prevent chemicals from directly attaching to the skin”, and there are no detailed measures or guidelines for preventing exposure.

  CPA is used as a multi-drug combination therapy for breast cancer treatment. It is used as an injection or internal medicine. However, when treatment with an injection is difficult or in some chemotherapy regimens (such as CMF therapy), oral medicine (Endoxan tablets: Daily administration of CPA by registered trademark is required.

  However, for cancer patients with dysphagia, administration methods such as pulverized preparation are necessary, but at present, a method for safe preparation and administration by dispensers and administra- tors (nurses, caregivers, etc.) has been developed. There is a need for immediate exposure avoidance measures for those involved in administration with dangerous drugs represented by CPA.

JP 2008-264504 A

Naomi Kurata, supervised by Ichiro Fujishima “Handbook of Oral Drug Tube Administration Second Edition: List of Drugs Available for Simple Suspension Method” Jiho Co., Ltd. 2006 Koichi Kitada, Hirohisa Kato, Toshihiro Tsuji, Kiyoaki Nakayama, Shinichi Sugiura, “Hospital Handling Guidelines for Anticancer Drug Preparations 2nd Edition”, Jiho Co., Ltd.

  The problem to be solved by the present invention is that in a series of operations of tablet crushing and suspension, and suspension drug solution administration, tablet crushing and suspension, suspension drug solution administration cannot be performed in a closed system. .

  In the present invention, tablets are crushed in a closed system, and the crushed tablets are suspended in a closed system so that medical personnel are not exposed to dangerous drugs. The most important feature is administration to patients.

  That is, the tablet suspension administration device according to the present invention connects a tablet crushing syringe for crushing a tablet, a water supply syringe for supplying water, the tablet crushing syringe, and the water supply syringe. The tablet crushing syringe has a tablet crushing pin inside the three-way cock, and the three-way cock has three connection ends each having a flow path therein, and the three connection ends. A sliding valve body that selects and communicates two of the flow paths at the three connecting end portions at the confluence base, and the distal end portion of the tablet crushing syringe and the distal end portion of the water supply syringe are It is connected to any connecting end of the three-way stopcock.

  Here, the tablet crushing syringe and the water supply syringe may be formed of a light-transmitting material or a light-shielding material. When the tablet crushing syringe and the water supply syringe are formed of a light-shielding material, even a drug that is unstable to light can be suspended in the light-shielded state, so that the drug can be administered to the patient without reducing the drug efficacy. Can be administered.

  In addition, the method for administering a medicine according to the present invention is to put water in a syringe for water supply, put the tablet in a tablet crushing syringe, crush the tablet with the tablet crushing syringe, and crush the tablet crushing syringe and the water. In a state where the supply syringe is connected via a three-way stopcock, the tablet crushing syringe and the water supply syringe of the three-way stopcock are communicated with each other, and between the tablet crushing syringe and the water supply syringe Then, water and tablets are moved back and forth to disturb the water and tablets, and a tablet suspension comprising water and tablets obtained by this disturbance is administered to the patient via the three-way cock.

  Here, the tablet suspension is transferred to the water supply syringe, the path on the side of the tablet crushing syringe of the three-way stopcock is closed, and the tablet suspension in the water supply syringe is connected to the three-way stopcock. To the patient. Further, the tablet suspension may be administered to the patient from the three-way stopcock through a drug input tube or a nutrient supply tube set in the patient.

  Another tablet suspension administration apparatus according to the present invention includes a tablet crushing syringe for crushing a tablet, a water supply syringe for supplying water, the tablet crushing syringe, and the water supply syringe. A three-way stopcock that connects the three-way stopcock, a cleaning water supply syringe for supplying cleaning water, and a second three-way stopcock that connects the three-way stopcock and the cleaning water supply syringe. The three-way stopcock and the second three-way stopcock have pins for crushing the tablet, the three connection ends having flow paths therein, and the three connection ends at the merging base of the three connection ends. A sliding valve element that selects and communicates two of each of the flow paths, and the distal end portion of the tablet crushing syringe and the distal end portion of the water supply syringe are connected end portions of any of the three-way stopcocks Connected to either end of the second three-way stopcock is the three-way stopcock Connected to the connecting end of the unconnected, the tip of the cleaning water supply syringe is characterized in that it is connected to the connecting end of the unligated the second three-way stopcock.

  Here, the tablet crushing syringe and the water supply syringe may be formed of a light-transmitting material or a light-shielding material. When the tablet crushing syringe and the water supply syringe are formed of a light-shielding material, even a drug that is unstable to light can be suspended in the light-shielded state, so that the drug can be administered to the patient without reducing the drug efficacy. Can be administered.

  Another method for administering a drug according to the present invention is to put water in a syringe for supplying water, put water in a syringe for supplying washing water, put a tablet in a syringe for crushing tablets, and use the syringe for crushing tablets. The tablet is crushed, and the tablet crushing syringe and the water supply syringe are connected via a three-way stopcock, and the tablet crushing syringe and the water supply syringe of the three-way stopcock are communicated with each other. Water and tablets are moved back and forth between the tablet crushing syringe and the water supply syringe to disturb the water and the tablet, and the tablet suspension comprising the water and the tablet obtained by this disturbance is transferred to the three-way stopcock and the second stopcock. Administering to the patient via the three-way stopcock, and feeding the water in the washing water supply syringe to the administration route of the tablet suspension from the second three-way stopcock to the patient via the second three-way stopcock Features.

  Here, the tablet suspension is transferred to the water supply syringe, the path on the side of the tablet crushing syringe of the three-way stopcock is closed, and the tablet suspension in the water supply syringe is transferred to the three-way stopcock and The patient may be administered via the second three-way stopcock.

  Further, the tablet suspension may be administered to the patient from the second three-way stopcock through a drug input tube or a nutrient supply tube set in the patient.

  The present invention is capable of crushing tablets in a closed system called a tablet crushing syringe, and crushing tablets in a closed system called a tablet crushing syringe, a water supply syringe and a three-way stopcock connecting them. Because it can be mixed with water (hot water), the drug is not exposed to the outside, and medical personnel are exposed to the drug even if the drug is a cytotoxic or secondary carcinogenic drug such as an anticancer drug. There is an effect that the medical staff can be safely engaged in the medical work without worrying to do so.

  Moreover, since the present invention can administer the tablet suspension from the three-way stopcock to the patient through a closed tube tube tube by switching the three-way stopcock, the drug is not exposed to the outside, Even if the drug is a dangerous drug having cytotoxicity or secondary carcinogenicity such as an anticancer drug, there is no worry that the medical worker is exposed to the drug, and the medical worker can be safely engaged in medical work.

  In addition, since the present invention is connected to a syringe for washing via a three-way stopcock, the inside of a tube tube to which a tablet suspension is administered can be washed in a closed system set in a patient. When the suspension administration device is removed from the patient, the drug is not exposed to the outside, and even if the drug is a dangerous drug that has cytotoxicity or secondary carcinogenicity such as an anticancer drug, the health care worker may be exposed to the drug. There is an effect that the medical staff can be safely engaged in medical work.

  In addition, the present invention can clean the inside of a tube tube or a three-way stopcock in a closed system state even with the use of a dangerous drug having cytotoxicity or secondary carcinogenicity such as an anticancer agent. The stopcock can be removed safely, and there is an effect that used instruments can be safely discarded not only in medical facilities but also at home care.

  In the present invention, the tablet is crushed in a closed space called a tablet crushing syringe, and the crushed tablet and water are mixed in a closed system called a tablet crushing syringe connected with a three-way stopcock and a water supply syringe. Therefore, it is possible to produce a clean and clean tablet suspension free from contamination by foreign substances and bacteria, and therefore, it is possible to administer a clean and clean tablet suspension to a patient.

  In the present invention, since the tablet crushing syringe and the water supply syringe are connected via a three-way stopcock, the crushed tablet and water are moved back and forth between the tablet crushing syringe and the water supply syringe. The tablet suspension and water are forcibly disturbed, and the tablet suspension can be easily made in a short time, and the tablet suspension can be immediately administered to the patient.

  In addition, the present invention can easily administer the tablet suspension to the patient because the tablet suspension can be administered from the three-way stopcock to the patient via the tube by switching the three-way stopcock. There is an effect.

  In addition, the present invention has an effect that, by connecting the three-way stopcocks, a plurality of drugs can be administered in different systems without changing the composition of the drugs.

FIG. 1 is an explanatory diagram of a tablet suspension administration device according to Example 1 of the present invention. FIG. 2 is an explanatory diagram of a tablet crushing syringe. FIG. 3 is an explanatory diagram of a water supply syringe. FIG. 4 is an explanatory view of a three-way cock. FIG. 5 is a process diagram showing the procedure of the tablet suspension administration method using the apparatus of Example 1. FIG. 6 is an explanatory diagram of a tablet suspension administration device according to Example 2 of the present invention. FIG. 7 is an explanatory view of a washing water supply syringe. FIG. 8 is a process chart showing the procedure of the tablet suspension administration method using the apparatus of Example 2. It is a graph which shows the result of having analyzed the cyclophosphamide in a passive sampler with a liquid chromatograph / tandem mass spectrometer (LC / MS / MS).

  A simple device is used for the purpose of pulverizing tablets in a closed system, suspending the crushed tablets in a closed system, and administering the obtained suspension drug solution to the patient in a closed system. Realized without.

  FIG. 1 is an explanatory diagram of a tablet suspension administration device according to Example 1 of the present invention. In the figure, 10 is a tablet crushing syringe, 12 is a water supply syringe, and the tablet crushing syringe 10 and the water supply syringe 12 are connected to each other via a three-way cock 14. A connecting tube 16 is connected to the unconnected connecting end of the three-way cock 14.

  FIG. 2 is an explanatory diagram of a tablet crushing syringe. As shown in the figure, the tablet crushing syringe 10 is connected to a substantially cylindrical outer cylinder 10a, a substantially cylindrical gasket 10b slidably inserted into the outer cylinder 10a, and a rear portion of the gasket 10b. The plunger 10c moves the gasket 10b back and forth.

  The outer cylinder 10a of the tablet crushing syringe 10 is generally formed of a light-transmitting plastic material, but may be formed of a light-shielding plastic material. A distal end portion 10f for fitting an injection needle is formed on the distal end side of the outer cylinder 10a of the tablet crushing syringe 10 so as to protrude. The distal end portion 10f is formed of a substantially cylindrical body having a through hole formed in the center and tapered toward the distal end side.

  A tablet crushing pin 10d is provided inside the outer cylinder 10a of the tablet crushing syringe 10 so as to protrude inward. Moreover, the recessed part 10e for putting a tablet is formed in the front end side of the gasket 10b of the syringe 10 for tablet crushing.

  FIG. 3 is an explanatory diagram of a water supply syringe. As shown in the figure, the water supply syringe 12 is connected to a substantially cylindrical outer cylinder 12a, a substantially cylindrical gasket 12b slidably inserted into the outer cylinder 12a, and a rear portion of the gasket 12b. And a plunger 12c for moving the gasket 12b back and forth.

  The outer cylinder 12a of the water supply syringe 12 is generally formed of a light-transmitting plastic material, but may be formed of a light-blocking plastic material. A tapered distal end portion 12d for fitting the injection needle is formed on the distal end side of the outer cylinder 12a of the water supply syringe 12 so as to protrude. The distal end portion 12d is formed of a substantially cylindrical body having a through-hole formed at the center and tapered toward the distal end side.

  FIG. 4 is an explanatory view of a three-way cock. The three-way stopcock 14 is generally commercially available and includes three cylindrical connection ends 14a. As for the connection end part 14a, one side is in an open state, respectively, and the other side is in a connected state. A sliding valve body is rotatably provided at a portion of the three connecting end portions 14a that are connected to each other, and a cock 14b is integrally provided on the sliding valve body. The sliding valve body is hidden under the cock 14b and cannot be seen.

  The sliding valve body of the three-way stopcock 14 is formed with a T-shaped through hole perpendicular to the rotation axis of the sliding valve body, and the end of the through hole of the sliding valve body and the end of the through hole of the connecting end In combination, the flow path of the three-way cock 14 can be selected. The end portion of the through hole of the sliding valve body and the end portion of the through hole of the connecting end portion can be matched by rotating the cock 14b together with the sliding valve body.

  The leading end 10d of the tablet crushing syringe 10 is connected to one connecting end 14a of the three-way stopcock 14, and the leading end 12d of the water supply syringe 12 is connected to the other connecting end 14a of the three-way stopcock 14. Yes. A connecting tube 16 is connected to the remaining connecting end 14 a of the three-way cock 14. The connection tube 16 is for connecting the remaining connecting end 14a to a transtube tube (not shown) set in the patient.

  Next, a method of using the tablet suspension administration device according to Example 1 will be described with reference to the process chart shown in FIG.

  First, the water supply syringe 12 is removed from the connecting end 14a of the three-way stopcock 14, the tip 12d of the water supply syringe 12 is immersed in a pre-filled cup, and the plunger 12c is pulled to supply water. Water is put into the syringe 12, and the water supply syringe 12 is connected to the original connecting end 14 a of the three-way cock 14.

  Further, the tablet crushing syringe 10 is removed from the connecting end of the three-way cock 14, the gasket 10b and the plunger 10c are extracted from the outer cylinder 10a of the tablet crushing syringe 10, the tablet is put into the outer cylinder 10a, and the gasket 10b and the plunger 10c. Is returned to the outer cylinder 10a, and the tip portion 10f of the tablet crushing syringe 10 is connected to the connecting end portion 14a.

  The distal end side of the plunger 10c is directed upward together with the tablet crushing syringe 10, and the tablet is placed in the recess 10e of the gasket 10b on the distal end side of the plunger 10c. In this state, the plunger 10c is pushed, and the tablet is gasketed on the tablet crushing pin 10d. Press with 10b to break the tablet.

  Here, the three-way stopcock 14 rotates the cock 14d together with the sliding valve body, the connection tube 16 side is closed, and the connection end 14a connected to the tablet crushing syringe 10 and the water supply syringe. A flow path is formed so as to communicate with the connection end portion 14 a connected to the terminal 12.

  Next, the plunger 12c of the water supply syringe 12 and the plunger 10c of the tablet crushing syringe 10 were alternately pushed, and water and tablets were moved back and forth between the tablet crushing syringe 10 and the water supply syringe 12 to be crushed. Water is disturbed together with the tablet, the crushed tablet is made into a suspension, and finally, all of the suspended drug solution is transferred to the water supply syringe 12.

  Next, the connecting tube 16 is connected to a transluminal tube set in the patient, the cock 14d of the three-way cock 14 is rotated together with the sliding valve body, and the connecting end 14a to which the tablet crushing syringe 10 is connected is connected. The side is closed and the side of the connecting end 14 a connected to the end of the connecting tube 16 is opened.

  Next, the plunger 12 c of the water supply syringe 12 is pushed, and the suspended chemical solution in the water supply syringe 12 is sent to the connection tube 16 side through the three-way cock 14. The suspension drug solution sent to the connecting tube 16 is administered to the patient through the tube. Here, the transtube tube set in the patient may be a drug input tube or a nutrient supply tube.

  FIG. 6 is an explanatory diagram of a tablet suspension administration device according to Example 2 of the present invention. As shown in the figure, the tablet suspension administration device includes a tablet crushing syringe 10 for crushing tablets, a water supply syringe 12 for supplying water, a tablet crushing syringe 10 and water supply. A three-way cock 14 for connecting the syringe 12, a cleaning water supply syringe 18 for supplying cleaning water, and a second three-way cock 20 for connecting the three-way cock 14 and the cleaning water supply syringe 18 are provided.

  This tablet suspension administration device is different from the tablet suspension administration device of Example 1 only in that the washing water supply syringe 18 is attached to the tablet suspension administration device according to Example 1 via the second three-way cock 20. is doing. Therefore, description of the same part as the tablet suspension administration apparatus of Example 1 is abbreviate | omitted, and only a different point is demonstrated.

  FIG. 7 is an explanatory view of a washing water supply syringe. As shown in the figure, the cleaning water supply syringe 18 is connected to a substantially cylindrical outer cylinder 18a, a substantially cylindrical gasket 18b slidably inserted into the outer cylinder 18a, and a rear portion of the gasket 18b. The plunger 18c moves the gasket 18b back and forth.

  The outer cylinder 18a of the washing water supply syringe 18 is formed of a light-transmitting plastic material. A tapered distal end portion 18d for fitting an injection needle is formed on the distal end side of the outer cylinder 18a of the syringe 18 for supplying cleaning water. The tip end portion 18d is formed of a substantially cylindrical body having a through-hole formed at the center and tapered toward the tip end side.

  Next, a method for using the tablet suspension administration device according to the second embodiment will be described with reference to the process chart shown in FIG.

  First, the water supply syringe 12 is removed from the connecting end portion 14a of the three-way stopcock 14 (hereinafter referred to as the first three-way stopcock 14 for convenience of expression), and this water supply is provided in a previously charged cup. The tip 12 d of the syringe 12 is immersed, the plunger 12 c is pulled to put water into the water supply syringe 12, and the water supply syringe 12 is connected to the original connection end 14 a of the first three-way cock 14.

  Further, the tablet crushing syringe 10 is removed from the connecting end of the first three-way cock 14, the gasket 10b and the plunger 10c are extracted from the outer cylinder 10a of the tablet crushing syringe 10, the tablet is put in the outer cylinder 10a, and the gasket 10b and The plunger 10c is returned to the outer cylinder 10a, and the tip portion 10f of the tablet crushing syringe 10 is connected to the connecting end portion 14a.

  The distal end side of the plunger 10c is directed upward together with the tablet crushing syringe 10, and the tablet is placed in the recess 10e of the gasket 10b on the distal end side of the plunger 10c. In this state, the plunger 10c is pushed, and the tablet is gasketed on the tablet crushing pin 10d. Press with 10b to break the tablet.

  Here, the first three-way stopcock 14 rotates the cock 14b together with the sliding valve body to close the second three-way stopcock 20 side, and connects the connection end 14a connected to the tablet crushing syringe 10 with water. A flow path is formed so as to communicate with the connection end portion 14 a connected to the supply syringe 12.

  Next, the plunger 12c of the water supply syringe 12 and the plunger 10c of the tablet crushing syringe 10 are alternately pressed, water and tablets are moved back and forth between the tablet crushing syringe 10 and the water supply syringe 12, and the water is crushed. Then, the crushed tablet is made into a suspension, and finally, all of the suspended drug solution is transferred to the water supply syringe 12.

  Next, the second three-way stopcock 20 is connected to the third three-way stopcock 24 in the middle of the nutrient supply tube 22, and the cock 14 b of the first three-way stopcock 14 is rotated together with the sliding valve body to The side is closed and the second three-way cock 20 side is opened. Then, the cock 20b of the second three-way cock 20 is rotated together with the sliding valve body so that the third three-way cock 24 side is opened and the cleaning water supply syringe 18 side is closed. Then, the cock of the third three-way cock 24 is rotated together with the sliding valve body so that the nutrient side is closed and the second three-way cock 20 side is opened.

  Next, the plunger 12c of the water supply syringe 12 is pushed, and the suspended chemical solution in the water supply syringe 12 is transferred to the third three-way of the nutrient solution supply tube 22 through the first three-way stopcock 14 and the second three-way stopcock 20. Send to stopcock 24. The suspended drug solution enters the nutrient solution supply tube 22 via the third three-way cock 24 and is administered to the patient through the nutrient solution supply tube 22.

  Next, the tip 18d of the cleaning water supply syringe 18 is dipped in a glass in which water has been put in advance, the plunger 18c is pulled to put water into the cleaning water supply syringe 18, and the cleaning water supply syringe 18 is drawn. Is connected to the original connecting end 20 a of the second three-way cock 20. Then, the cock 20b of the second three-way cock 20 is rotated together with the sliding valve body so that the first three-way cock 14 side is closed and the cleaning water supply syringe 18 side is opened.

  Next, the plunger 18 c of the cleaning water supply syringe 18 is pushed, and the cleaning water in the cleaning water supply syringe 18 is sent to the second three-way stopcock 20 and the third three-way stopcock 24 via the second three-way stopcock 20. The washing water enters the nutrient supply tube 22 while washing the inside of the second three-way cock 20 and the third three-way cock 24.

  In this state, since the insides of the second three-way cock 20 and the third three-way cock 24 are washed with washing water, even if the apparatus is removed between the second three-way cock 20 and the third three-way cock 24, the suspension is suspended. There is no worry about exposure to drugs.

  Using the tablet suspension administration device according to the present invention, when the suspension of the coatryl tablet, which is a general drug, was performed, the suspension of the tablet could be made in 1 minute even when using room temperature water. Administration was possible.

  On the other hand, in the description of Courtryl tablet in the simple suspension method handbook, when the tablet is suspended with 20 mL of hot water at 55 ° C., the suspension cannot be made in 5 minutes, and the suspension can be made in 10 minutes. It is marked as possible.

  Therefore, when the tablet suspension administration device according to the present invention is used, from tablet crushing to suspension and administration can be performed in 20 mL of tap water (25 ° C.) for 1 minute without preparation of hot water. It has been found that the drug can be administered in suspension much faster than the method.

  In addition, a tablet suspension drug solution is formed using the tablet suspension administration device according to the present invention, and the active ingredient of this suspension drug solution is quantitatively analyzed with a liquid chromatography / UV-visible light detector to determine the recovery rate of the active ingredient. As a result, the recovery rate of the main drug was 95% to 100%. Therefore, it was found that when a tablet suspension drug solution was formed using the tablet suspension administration device according to the present invention, almost all drugs could be administered without loss of the main drug.

  Attach a commercially available high-performance passive sampler (VOC-SD solvent extraction, manufactured by Sigma-Aldrich) to the mouth, and use the anticancer drug Endoxan tablet to perform a series of operations from tablet breakage to suspension administration with the present instrument, Cyclophosphamide was measured with a liquid chromatograph / tandem mass spectrometer (LC / MS / MS).

  As a result, in all samples (n = 5), cyclophosphamide is below the detection limit (0.005 ng / mL), and the device of the present invention is safe against drug exposure in a series of operations from tablet destruction to suspension administration. I was able to confirm the sex.

  Further, as a comparative example, the endoxan tablet was pulverized and suspended by a conventional pulverization method, and the exposure situation during the administration process was examined.

  Here too, a passive sampler is attached to the mouth of the pharmacist and the recipient, and the endoxan tablet pulverized preparation and pulverized powder suspension are administered, and the passive sampler is used with a liquid chromatograph / tandem mass spectrometer (LC / MS / MS). The cyclophosphamide in (each N = 5) was analyzed.

  As a result, as shown in FIG. 9, the anti-cancer agent cyclophosphamide (CPA) was detected in the range of 10 to 100 μg from all samplers of the dispenser (n = 5) and the administration person (n = 5). The risk of exposure to anticancer drugs was confirmed not only by the patient but also by the recipient.

DESCRIPTION OF SYMBOLS 10 Tablet crushing syringe 10a Outer cylinder 10b Gasket 10c Plunger 10d Pin 10d Tip part 10e Recess 10f Tip part 12 Water supply syringe 12a Outer cylinder 12b Gasket 12c Plunger 12d Tip part 14 Three-way cock 14a Connecting end 14b Cock 16 Connecting tube 18 Washing water supply syringe 18a Outer cylinder 18b Gasket 18c Plunger 18d Tip 20 Second three-way stopcock 20a Connection end 22 Nutrient supply tube 24 Third three-way stopcock

Claims (11)

  A tablet crushing syringe for crushing a tablet, a water supply syringe for supplying water, a three-way cock connecting the tablet crushing syringe and the water supply syringe, A tablet crushing pin is provided inside, and the three-way stopcock has three connecting end portions each having a flow path therein, and each flow of the three connecting end portions at a merging base portion of the three connecting end portions. A sliding valve body for selecting and communicating two of the passages, and the distal end portion of the tablet crushing syringe and the distal end portion of the water supply syringe are connected to one of the connecting end portions of the three-way stopcock A tablet suspension administration device.   The tablet suspension administration device according to claim 1, wherein the tablet crushing syringe and the water supply syringe are made of a light-shielding material.   Put water in the water supply syringe, put the tablet in the tablet crushing syringe, crush the tablet with the tablet crushing syringe, and connect the tablet crushing syringe and the water supply syringe through a three-way cock. In this state, the tablet crushing syringe and the water supply syringe of the three-way cock are communicated, and water and tablets are moved back and forth between the tablet crushing syringe and the water supply syringe. And a tablet suspension administration method, wherein the tablet is suspended by suspension.   Put water in the water supply syringe, put the tablet in the tablet crushing syringe, crush the tablet with the tablet crushing syringe, and connect the tablet crushing syringe and the water supply syringe through a three-way cock. In this state, the tablet crushing syringe and the water supply syringe of the three-way cock are communicated, and water and tablets are moved back and forth between the tablet crushing syringe and the water supply syringe. A tablet suspension administration method comprising: disrupting the suspension together to form a tablet suspension, and administering the obtained tablet suspension to a patient via the three-way stopcock.   The tablet suspension is transferred to the water supply syringe, the path of the three-way stopcock on the side of the tablet crushing syringe is closed, and the tablet suspension in the water supply syringe is passed through the three-way stopcock to the patient. The tablet suspension administration method according to claim 4, wherein the tablet suspension is administered.   The tablet suspension administration method according to claim 4 or 5, wherein the tablet suspension is administered to the patient from the three-way stopcock through a drug feeding tube or a nutrient supply tube set in the patient.   Tablet crushing syringe for crushing tablets, water supply syringe for supplying water, three-way cock connecting the tablet crushing syringe and water supply syringe, and washing for supplying washing water A syringe for water supply, and a second three-way stopcock connecting the three-way stopcock and the syringe for supplying cleaning water. The tablet crushing syringe includes a pin for tablet crushing inside, and the three-way stopcock and the second stopcock The three-way stopcock has three connecting end portions each having a flow path therein, and a slide for selecting and communicating two of the three flow paths at the three connecting end portions at the joining base portion of the three connecting end portions. A distal end portion of the tablet crushing syringe and a distal end portion of the water supply syringe are connected to any connecting end portion of the three-way stopcock, and any connecting end of the second three-way stopcock is provided. Is connected to the unconnected connecting end of the three-way stopcock, and the washing water supply Tip of the syringe tablet suspended administration apparatus characterized by being connected to the connecting end of the unligated the second three-way stopcock.   The tablet suspension administration device according to claim 7, wherein the tablet crushing syringe and the water supply syringe are made of a light-shielding material.   Put water in the syringe for water supply, put water in the syringe for supply of washing water, put the tablet in the syringe for tablet crushing, crush the tablet with the syringe for crushing tablet, and crush the tablet crushing syringe and the water In a state where the supply syringe is connected via a three-way stopcock, the tablet crushing syringe and the water supply syringe of the three-way stopcock are communicated with each other, and between the tablet crushing syringe and the water supply syringe The water and the tablet are moved back and forth to disturb the water together with the tablet to make the tablet suspension, and the obtained tablet suspension is administered to the patient through the three-way stopcock and the second three-way stopcock, and the second three-way A tablet suspension administration method, wherein water in a washing water supply syringe is fed through the second three-way stopcock to an administration route of the tablet suspension from a stopcock to a patient.   The tablet suspension is transferred to the water supply syringe, the path on the side of the tablet crushing syringe of the three-way stopcock is closed, and the tablet suspension in the water supply syringe is transferred to the three-way stopcock and the second stopcock. The tablet suspension administration method according to claim 9, wherein the tablet suspension is administered to a patient via a three-way stopcock.   The tablet suspension administration according to claim 9 or 10, wherein the tablet suspension is administered to the patient from the second three-way stopcock via a drug feeding tube or a nutrient supply tube set in the patient. Method.

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