JP2012102017A - インドール化合物 - Google Patents

インドール化合物 Download PDF

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Publication number
JP2012102017A
JP2012102017A JP2009049019A JP2009049019A JP2012102017A JP 2012102017 A JP2012102017 A JP 2012102017A JP 2009049019 A JP2009049019 A JP 2009049019A JP 2009049019 A JP2009049019 A JP 2009049019A JP 2012102017 A JP2012102017 A JP 2012102017A
Authority
JP
Japan
Prior art keywords
mixture
compound
added
ethyl acetate
stirred
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2009049019A
Other languages
English (en)
Japanese (ja)
Inventor
英範 ▲薊▼
Hidenori Azami
Tomoaki Abe
友亮 阿部
Akio Kakefuda
昭夫 掛札
Yutaka Kondo
裕 近藤
Kazushi Watanabe
和志 渡邉
Akio Kamikawa
晃雄 神川
Minoru Yasuda
実 安田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Priority to JP2009049019A priority Critical patent/JP2012102017A/ja
Priority to PCT/JP2010/053281 priority patent/WO2010101127A1/fr
Publication of JP2012102017A publication Critical patent/JP2012102017A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2009049019A 2009-03-03 2009-03-03 インドール化合物 Withdrawn JP2012102017A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009049019A JP2012102017A (ja) 2009-03-03 2009-03-03 インドール化合物
PCT/JP2010/053281 WO2010101127A1 (fr) 2009-03-03 2010-03-02 Composé indole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009049019A JP2012102017A (ja) 2009-03-03 2009-03-03 インドール化合物

Publications (1)

Publication Number Publication Date
JP2012102017A true JP2012102017A (ja) 2012-05-31

Family

ID=42709684

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009049019A Withdrawn JP2012102017A (ja) 2009-03-03 2009-03-03 インドール化合物

Country Status (2)

Country Link
JP (1) JP2012102017A (fr)
WO (1) WO2010101127A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170121606A1 (en) * 2015-10-30 2017-05-04 Merck Patent Gmbh Polymerizable compounds and the use thereof in liquid-crystal displays

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2903657A1 (fr) 2013-02-27 2014-09-04 Shionogi & Co., Ltd. Derives d'indole et d'azaindole ayant chacun une activite d'activation d'ampk
JP6090666B2 (ja) * 2013-05-20 2017-03-08 国立大学法人富山大学 インドール誘導体および血糖降下剤。
CN110092791B (zh) * 2019-05-17 2020-04-03 河南大学 5,6-吲哚并二恶烷类衍生物及其制备方法和应用
US20240059688A1 (en) * 2020-12-22 2024-02-22 Luxembourg Institute Of Health (Lih) Conolidine analogues as selective ackr3 modulators for the treatment of cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002336273A1 (en) * 2001-03-09 2002-09-24 Ortho-Mcneil Pharmaceutical, Inc. Heterocyclic compounds and their use as histamine h4 ligands.
EP1545596A4 (fr) * 2002-09-06 2005-12-28 Janssen Pharmaceutica Nv Utilisation de modulateurs du recepteur h4 de l'histamine pour le traitement des allergies et de l'asthme
SE0302116D0 (sv) * 2003-07-21 2003-07-21 Astrazeneca Ab Novel compounds
EP1676843A1 (fr) * 2004-12-31 2006-07-05 Nikem Research S.R.L. Ligands d'indole substitues destines un recepteur ORL-1
EP1873150A1 (fr) * 2006-06-30 2008-01-02 Nikem Research S.R.L. Indoleamides fluores utiles comme ligands du recepteur ORL-1
PE20081897A1 (es) * 2007-03-29 2009-02-09 Novartis Ag 3-imidazolil-indoles para el tratamiento de enfermedades proliferativas
ES2392120T3 (es) * 2007-08-31 2012-12-04 Astellas Pharma Inc. Derivado de piperidina

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170121606A1 (en) * 2015-10-30 2017-05-04 Merck Patent Gmbh Polymerizable compounds and the use thereof in liquid-crystal displays
CN106947497A (zh) * 2015-10-30 2017-07-14 默克专利股份有限公司 可聚合化合物及其在液晶显示器中的用途
US11312909B2 (en) * 2015-10-30 2022-04-26 Merck Patent Gmbh Polymerizable compounds and the use thereof in liquid-crystal displays

Also Published As

Publication number Publication date
WO2010101127A1 (fr) 2010-09-10

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Legal Events

Date Code Title Description
A300 Withdrawal of application because of no request for examination

Free format text: JAPANESE INTERMEDIATE CODE: A300

Effective date: 20120605