JP2012098144A - Analysis device and display control method of the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To display display items related to analysis of both analysis devices with one display unit without confusion, when additionally attaching an analysis device without a display section to an analysis device having a display section.SOLUTION: The analysis device includes a display section 11, and a display control section 80 for allowing the display section 11 to make display according to priority order specified in a table form beforehand, and is allowed to be additionally attached with analysis devices 200 and 300 having no display section. When the analysis devices 200 and 300 having no display section are attached, the table is updated to re-set the priority order so that display items relevant to the analysis of attached analysis devices 200 and 300 are added to the priority order.

Description

  The present invention relates to an analysis apparatus, and more particularly, to an analysis apparatus having a configuration including a display unit and capable of adding an analysis apparatus having no display unit.

  The present invention also relates to a display control method in such an analyzer.

  In recent years, a large number of assay devices have been developed that hold a test substance (sample) that may contain a test substance on a carrier, and that can easily and quickly test this test substance using an assay such as immunological measurement. Various devices for in-vitro diagnostics, toxic substances, and the like are also commercially available. As an example of such a device, one utilizing an immunochromatographic method as shown in Patent Document 1 can be cited. In the case of using a device utilizing the immunochromatography method, the test result can be obtained by holding the sample solution on a carrier and then allowing it to stand for about 5 to 10 minutes. For this reason, a test method using an assay method such as an immunological test is widely adopted as a simple and quick test method, for example, in a clinical test in a hospital or a test test in a laboratory.

  In particular, in clinical settings such as clinics, clinics, and home medical care, immunochromatographic analyzers (immunochromatography readers) are used as point-of-care testing (POCT) clinical analyzers that perform simple tests regardless of clinical laboratory specialists. ) Is often used. This immunochromatographic analyzer measures the coloration state of the reagent of the loaded device with high sensitivity, and enables high-sensitivity and highly reliable inspection even in a low coloration state where visual judgment is difficult. . Patent Document 2 shows an example of this type of analyzer.

  In the analysis apparatus described above, a display unit for displaying the analysis result is often provided. In such a display unit, for example, as shown in Patent Document 3, a plurality of items including not only the analysis result but also the device state and the like are generally displayed after setting priorities. Is. For example, when three items are displayed: (1) an apparatus malfunction that is an example of the apparatus state, (2) an analysis result, and (3) an estimated time until the completion of the currently processed analysis that is an example of the apparatus state. In that case, the priority is usually higher as the number is smaller. That is, in this example, if a malfunction of the apparatus occurs during the measurement, it is first required to notify the apparatus user to that effect.

  On the other hand, in the analysis apparatus as described above, there is a case where expansion of the analysis processing capacity is required with the expansion of the scale of a medical institution, etc. Therefore, as shown in Patent Document 4, for example, an extension machine is added It has also been proposed to connect and use.

JP 2008-139297 A JP 2009-13381 A JP-A-6-281656 JP 2007-10560 A

  By the way, when the existing analyzer is provided with a display unit for displaying the test result or the like, it is preferable that the display unit of the existing machine is also used for the extension machine when the extension machine is connected to the analyzer. By doing so, a comparatively simple configuration without a display unit can be applied to the analyzer as an expansion machine, so that the cost for expansion is reduced and the overall installation area of the apparatus is reduced. It is advantageous in suppressing it.

  However, if the existing analyzer equipped with a display unit is configured to display a plurality of items related to analysis by setting their priorities, the display unit can also be used as an extension machine. If it is left as it is, there is a possibility that the priority order is confused with the extension machine, and the items related to the analysis in the extension machine are not displayed.

  The present invention has been made in view of the above circumstances, and when an analyzer having a display unit is added to an analyzer having a display unit, display items related to analysis in both the analyzers are displayed. It is an object of the present invention to provide a display control method for an analyzer that can be displayed without confusion.

  Another object of the present invention is to provide an analyzer that can implement such a display control method.

The display control method of the analyzer according to the present invention includes:
A display unit;
A display control unit that displays a plurality of display items related to analysis on the display unit in accordance with a predetermined priority order defined in advance in the form of a table;
In analyzers that can be expanded with other analyzers that do not have a display,
When the other analyzer is added, the table is updated so that the priority is reset by adding display items related to the analysis in the analyzer.
Here, the above-mentioned “display items related to analysis” means all display items related to analysis. Specifically, the presence / absence or status of a device failure, time until completion of analysis, analysis As a result, patient (subject) information, analyst information and the like can be mentioned.

  In the display control method of the analyzer according to the present invention, when the display items related to the analysis in the added analyzer are the same as the plurality of display items whose priority is defined by the table, It is desirable to update the table so that the priority order of the former display item matches the priority order of the latter display item.

On the other hand, the analyzer according to the present invention is:
A display unit;
A display control unit that displays a plurality of display items related to analysis on the display unit in accordance with a predetermined priority order defined in advance in the form of a table;
In analyzers that can be expanded with other analyzers that do not have a display,
The display control unit is configured to perform table update processing for resetting the priority order in addition to display items related to analysis in the analysis device when the other analysis device is added. It is a feature.

  In the analyzer according to the present invention, when the display items related to the analysis in the added analyzer are common to a plurality of display items whose priorities are defined by the table, the former display It is desirable that the display control unit is configured so that the priority order of items matches the priority order of the latter display items.

  The display control method for an analyzer according to the present invention includes a display unit, and a display control unit that displays a plurality of display items related to analysis on the display unit in accordance with a predetermined priority order defined in advance in the form of a table, In an analyzer that can be expanded with an analyzer that does not have a display unit, when an analyzer that does not have a display unit is added, the priority is reset by adding display items related to the analysis in the analyzer. Thus, according to this method, display items related to analysis in all the analyzers can be displayed without any confusion by the common display unit even after the addition.

  Further, particularly in the display control method of the analyzer according to the present invention, when the display items related to the analysis in the added analyzer are the same as the plurality of display items whose priority is defined by the table, If you update the table so that the priority of the former display item matches the priority of the latter display item, the display item priority will not change before and after the expansion. The operability can be maintained well.

  On the other hand, an analysis apparatus according to the present invention includes a display unit, and a display control unit that displays a plurality of display items related to analysis on the display unit in accordance with a predetermined priority order defined in advance in the form of a table. In the analysis apparatus in which an analyzer having no display can be added, the display control unit adds the display items related to the analysis in the analyzer when the analyzer having no display is added, and the priority order Since this table is configured to perform table update processing for resetting, the analysis apparatus display control method according to the present invention described above can be implemented.

The perspective view which shows the analyzer by one Embodiment of this invention Partially broken side view of the analyzer Block diagram showing the electrical configuration of the analyzer Front view showing part of the analyzer The partially broken top view which shows one state of the cartridge used for the said analyzer Partially cutaway plan view showing another state of the cartridge Partially cutaway plan view showing still another state of the cartridge Block diagram showing the electrical configuration when another analyzer is added to the analyzer

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. FIG. 1 is a perspective view of an immunochromatographic analyzer 1 according to an embodiment of the present invention, FIG. 2 is a partially broken side view thereof, and FIG. 3 is an electrical configuration thereof. First, the basic configuration of the present apparatus will be described with reference to FIGS.

  As shown in these drawings, the analyzer 1 includes a housing 10 having three openings 10a on the front surface, a display unit 11 arranged on the top surface of the housing 10, and a menu displayed on the display unit 11. An operation unit 12 for performing an operation, a power switch 13, and a cartridge loading unit 14 for introducing and loading an immunochromatographic cartridge (inspection reaction container) 20 into the apparatus are provided. One cartridge loading section 14 is provided for each of the three openings 10a, so that the analyzer 1 of the present embodiment can perform analysis processing on the three cartridges 20 in parallel. It has become.

  Further, inside the housing 10, a rail 15 that guides the cartridge loading unit 14 so as to be movable in the left-right direction in FIG. 2, and a pressing unit 30 for crushing a cleaning liquid pot 27 and a sensitizing liquid pot 28 described later, respectively. , 34 and a first measurement unit 40 and a second measurement unit 50 that acquire information from the cartridge 20. Three sets of the above configuration are also provided corresponding to the three cartridge loading sections 14.

  Hereinafter, the configuration corresponding to one cartridge 20 will be described in detail, but the configuration corresponding to the other two cartridges 20 is also exactly the same. The cartridge loading unit 14 is movable along the rail 15 automatically or manually. When most of the cartridge passes through the opening 10a and is taken out of the housing 10, the cartridge 20 supplied with the test solution (sample) is placed thereon as described below. Thereafter, the cartridge loading unit 14 is pushed into the housing 10 as shown in FIG. 2, whereby the cartridge 20 is taken into the analyzer 1.

  FIG. 4 is a front view showing a state where the pressing portions 30 and 34 are viewed from the left side in FIG. Here, the cartridge 20 is shown broken away. Hereinafter, the pressing portions 30 and 34 will be described with reference to FIG. The pressing portion 30 includes an arm 31 that is rotatable around a shaft 31 a like a seesaw, a pressing piece 32 that is fixed to a lower end of the arm 31, and a cam that is disposed below the rear end of the arm 31. 33. The cam 33 is connected to a drive shaft 39 rotated by a motor 38 so as to be freely connected and disconnected via an electromagnetic clutch (not shown), for example. When the cam 33 rotates, the rear end of the arm 31 is pushed up, and the pressing piece 32 at the tip moves downward. The other pressing portion 34 also has an arm 35, a pressing piece 36, and a cam 37 and is configured in the same manner as the pressing portion 30.

  Here, the pressing piece 32 of the pressing portion 30 and the pressing piece 36 of the pressing portion 34 are respectively the cleaning liquid pot 27 disposed inside the cartridge when the cartridge 20 is disposed at a predetermined position in the housing 10. It arrange | positions so that it may come to the position right above the liquid sensitive pot 28. FIG.

  FIG. 5 is a plan view showing the upper surface of the cartridge 20 in a cutaway manner. Hereinafter, the cartridge 20 will be described with reference to FIG. The cartridge 20 is formed on the upper surface of the case for spotting the sample solution on the insoluble carrier 21, the insoluble carrier 21 having the test line A, the test line B, and the control line C, the cartridge case 22 for containing the insoluble carrier 21. And an observation window 24 for observing the inspection site of the insoluble carrier 21 (the portions of the test lines A and B and the control line C). An information display unit 25 is provided on the upper surface of the cartridge case 22. The cartridge loading unit 14 is also provided with an observation window 14a that is substantially aligned with the observation window 24.

  The insoluble carrier 21 has an immobilized labeling substance. Test lines A and B each have a specific binding substance to the test substance immobilized as a reagent, and control line C is used to determine the end of measurement. In addition, the cartridge 20 in this embodiment is for analyzing positive / negative for influenza as an example.

  Further, an insoluble carrier 72 for liquid feeding and an insoluble carrier 73 for absorption are disposed inside the cartridge 20 with the insoluble carrier 21 sandwiched therebetween. The cleaning liquid pot 27 is fixed above the insoluble carrier 72 for feeding liquid, and the sensitizing liquid pot 28 is fixed above the end of the insoluble carrier 21 on the control line C side.

  The first measuring unit 40 measures the coloration state of the inspection site (the test lines A and B and the control line C) through the observation window 24 of the cartridge 20. As shown in FIG. 2, the first measurement unit 40 includes a camera 42 and a light source 44, and when the cartridge 20 is loaded in the analyzer 1, these are opposed to the observation window 24 from below the cartridge 20. It is configured. Then, based on the optical information on the examination site acquired by the first measurement unit 40, the optical density and chromaticity are calculated as the coloration state of the examination site (this will be described later).

Note the optical density, the intensity of light incident on the test site of the cartridge 20 I, when the intensity of the reflected light from the test site was a I _r, is defined by the following equation.

Optical density = −log ₁₀ (I _r / I)
The chromaticity is a numerical display of hue and saturation, and is calculated from RGB luminance signals read by the camera. As a chromaticity color system, a general CIE color system can be used.

  The camera 42 has, for example, a configuration in which a plurality of photodiodes are arranged in a line or an image sensor including an area sensor, and generates an output corresponding to the amount of received light. The light receiving range of the camera 42 is a belt-like range extending in the longitudinal direction of the cartridge 20. The light source 44 is a module in which, for example, an LED is built, and is configured to emit white light. The light source 44 may emit, for example, monochromatic light as long as the chromaticity before and after the sensitization process described later can be distinguished. When the light source 44 is composed of a plurality of modules, the light source 44 can also be composed of a plurality of modules that emit monochromatic light of different wavelengths. The light emitted from the light source 44 can illuminate a predetermined range in the longitudinal direction of the cartridge 20.

  On the other hand, the second measurement unit 50 irradiates the information display unit 25 of the cartridge 20 with illumination light and acquires information displayed on the information display unit 25. The information display unit 25 displays information related to the inspection by handwriting or sticker attachment. Information related to testing includes, for example, information related to the patient from whom the test substance was collected (name, age, gender, etc.) and information related to the sample / reagent used in the test (test substance, cleaning solution, sensitizing solution, etc. to be tested) Name). The method for acquiring information is not particularly limited, and the information display unit 25 can be imaged as it is or read from bar-coded information.

  As shown in FIG. 2, the second measuring unit 50 includes a camera 52 and a light source 54, and when the cartridge 20 is loaded into the analyzer 1, they face the information display unit 25 from above the cartridge 20. It is configured as follows. And the information regarding the test | inspection acquired by the 2nd measurement part 50 and a test result are linked | related and managed. Specific configurations of the camera 52 and the light source 54 are the same as those of the camera 42 and the light source 44 described above, respectively.

  Next, the electrical configuration of this apparatus will be described with reference to FIG. The operations of the pressing mechanisms 30 and 34 and the cameras 42 and 52 (including the light sources 44 and 54, respectively) including the display unit 11, the operation unit 12, and the motor 38 described above are controlled by the control unit 80 shown in FIG. The The analyzer 1 can be operated using, for example, a commercial power source of 100 to 240V, and the power source unit 100 that receives the commercial power source and converts it into a direct current of 12V, and the direct current of 12V are input. Switching unit 101. In addition, the analyzer 1 can be driven by a battery 102 as a secondary battery, and the battery 102 is also connected to the switching unit 101. The switching unit 101 receives a 12V DC current supplied from the power supply unit 100 when the commercial power supply is connected, and a 12V DC current supplied from the battery 102 when the commercial power supply is not connected. Switch to use in parts.

  In addition, a battery capacity monitoring unit 103 is connected to the switching unit 101 as battery remaining amount detecting means for detecting the remaining power amount of the battery 102. In general, because of its chemical characteristics, a battery has a characteristic that when the capacity decreases, the internal resistance increases and the terminal voltage decreases. Therefore, the residual power can be detected by measuring the terminal voltage. The battery capacity monitoring unit 103 thus continues to detect the remaining power amount of the battery 102 and inputs a signal indicating the remaining power amount to the control unit 80.

Next, the operation of the analyzer 1 of the present embodiment will be described. First, a specific measurement operation procedure will be described.
<< First stage >>
In this first stage, first, as shown in FIG. 5, for example, the sample solution 90 is spotted from the solution inlet 23 of the cartridge 20 outside the analyzer 1 and developed on the insoluble carrier 21. Thereafter, the cartridge 20 is disposed outside the analyzer 1 for a predetermined time, and then introduced and loaded into the analyzer 1 as described above.
<< Second stage >>
Here, first, the pressing portion 30 shown in FIGS. 2 and 4 is driven, the tip of the arm 31 is moved downward, and the pressing piece 32 crushes the cleaning liquid pot 27 in the cartridge 20 from the outside. As a result, as shown in FIG. 6, the cleaning liquid 91 stored in the cleaning liquid pot 27 cleans the inspection site of the insoluble carrier 21. At this time, the washing liquid 91 is sufficiently spread by the insoluble carrier 72 for liquid feeding, and then fed in the order of the insoluble carrier 21 and the insoluble carrier 73 for absorption.

  Next, the pressing portion 34 shown in FIGS. 2 and 4 is driven, the tip of the arm 35 is moved downward, and the pressing piece 36 crushes the sensitizing liquid pot 28 in the cartridge 20 from the outside. As a result, as shown in FIG. 7, the sensitizing solution 92 stored in the sensitizing solution pot 28 is sent to the inspection site of the insoluble carrier 21 to be sensitized. The sensitizing liquid 92 and the cleaning liquid 91 are disclosed in detail in, for example, Japanese Patent Application Laid-Open No. 2009-287952, and these can be applied in the present invention.

  After this sensitization processing, an image of the inspection site of the cartridge 20 is acquired by the camera 42 shown in FIG. The control unit 80 shown in the figure calculates the optical density and chromaticity of the image thus obtained, and displays the values, or the test results such as the presence or absence of a disease determined from these values, on the display unit 11. Let Thereafter, the cartridge 20 is taken out from the analyzer 1.

  Next, the expansion of the analyzer will be described. Hereinafter, a configuration including the cameras 42 and 52 and the pressing mechanisms 30 and 32 described above is referred to as a measurement unit U1 (see FIG. 3). As described above, in this embodiment, since two more units similar to the measurement unit U1 are installed, they are referred to as measurement units U2 and U3. As described above, the analysis processing can be performed on the three cartridges 20 in parallel using these measurement units U1 to U3.

  FIG. 8 shows an electrical configuration when another analyzer 200, 300 is added to the analyzer 1 as an existing machine. These analyzers 200 and 300 (which become “other analyzers” in the present invention) which are expansion machines are connected to the analyzer 1 via extension cables 150 and 151. The analyzing apparatus 200 includes measuring units U4, U5, and U6 having the same configuration as the measuring unit U1, and the analyzing apparatus 300 includes similar measuring units U7, U8, and U9. Therefore, in each of these analyzers 200 and 300, analysis processing can be performed in parallel with the three cartridges 20.

  The analyzers 200 and 300 are not equipped with a display unit for displaying the analysis results, and the items related to the analysis are shared with the display unit 11 of the analyzer 1 which is an existing machine. It is displayed. As described above, the analyzers 200 and 300 that do not include the display unit are advantageous in reducing the installation cost and the installation area required for the addition.

ここで、表中の表示優先度は、数値が大きいほど優先度が高いことを示す。なお「Ｕ１の処理状態」とは、測定ユニットＵ１の処理状態を示しており、他のＵ２〜９についても同様である。 Next, with respect to the display of analysis results and the like on the display unit 11, a case where no extension is made will be described. In this case, the control unit 80 in FIG. 3 which is also a display control unit displays a total of 10 display items such as analysis results on the display unit 11 by setting the display priority (priority order) shown in Table 1 below. Let

Here, the display priority in a table | surface shows that a priority is so high that a numerical value is large. The “processing state of U1” indicates the processing state of the measurement unit U1, and the same applies to the other U2 to U9.

  As shown in Table 1, in the present embodiment, the occurrence of a malfunction in the measurement units U1 to U3 is indicated as the priority “5”, that is, the first priority. This display is canceled by pressing an unillustrated ENTER key provided on the operation unit 12 (see FIG. 1). The item with the next highest priority “4” is a display that particularly shows the analysis result among the displays related to the processing state of the measurement units U1 to U3. This display is automatically terminated after being displayed for 10 seconds. The item with the next highest priority “3” is a display showing the time until the processing currently in progress is completed in the display related to the processing state of the measurement units U1 to U3. The display with the lowest priority is the standby screen.

  The control unit 80 stores the relationship between the display items shown in Table 1 and the priority order in the internal memory in the form of a lookup table. Then, when an event listed as a display item occurs in the analyzer 1, the control unit 80 refers to the table and controls each display according to the priority defined therein. That is, for example, when the analysis result of the measurement unit U1 is displayed on the display unit 11, if any trouble occurs in any of the measurement units U1 to U3, the display of the analysis result is forcibly terminated. Display a display showing the problem.

この表２に示される通り、増設された測定ユニットＵ４〜９における不具合表示については、既設の測定ユニットＵ１〜３における不具合表示と同様に、優先度「５」が規定されている。これは、測定ユニットＵ４〜９の分析結果表示と測定ユニットＵ１〜３の分析結果表示との間でも同様であって共に優先度「４」が規定され、さらに、測定ユニットＵ４〜９の処理完了までの時間表示と測定ユニットＵ１〜３の処理完了までの時間表示との間でも同様であって共に優先度「３」が規定されている。
なお、各表示項目に関する具体的データは、既設の測定ユニットＵ１〜３においても、また増設測定ユニットＵ４〜９においても、ユニット自身が保持しており、制御部８０がそれらを読み出して表示部１１に表示させる。 Next, display control when the above-described addition is performed will be described. In this case, the control unit 80 shown in FIGS. 3 and 8 causes the display unit 11 to display a total of 28 display items such as analysis results by setting the display priority shown in Table 2 below. The priority order is reset by updating the above-described table. The display items for the added measurement units U4 to U9 are held by the measurement units U4 to U9, and are read out by the control unit 80 and used for resetting the priority order. Note that the display item numbers shown in parentheses in Table 2 indicate the corresponding numbers in Table 1.

As shown in Table 2, priority indication “5” is defined for the failure display in the added measurement units U4 to U9, similarly to the failure display in the existing measurement units U1 to U3. This is the same between the analysis result display of the measurement units U4 to 9 and the analysis result display of the measurement units U1 to U3, both of which are defined with a priority “4”, and the processing of the measurement units U4 to 9 is completed. The same is true between the time display until and the time display until the processing of the measurement units U1 to U3 is completed, and the priority “3” is defined for both.
The specific data regarding each display item is held by the unit itself in the existing measurement units U1 to U3 and the extension measurement units U4 to U9, and the control unit 80 reads them to display the display unit 11. To display.

In this embodiment, as described above, the display items for the added measurement units U4 to U9 are held by the measurement units U4 to U9. In addition to this, the display for the measurement units that can be added is displayed. The control unit 80 may store the items in advance, and the control unit 80 may add the display items each time a measurement unit is added.
As described above, when the analyzers 200 and 300 that do not have a display unit are added, the table is updated, and the display items related to the added measuring units U4 to 9 are added to reset the display priority. Even after the expansion, only one display unit 11 can display the display items related to all the measurement units U1 to U9 without confusion.

  Particularly in the present embodiment, among the display items related to the added measuring units U4 to U9, those that are common to the display items whose priority is already specified by the table are specified priority. Therefore, the priority order of the display items does not change before and after the addition, so that the operability can be maintained satisfactorily.

  It should be noted that it is not always necessary to give matching priorities as described above. For example, if the added analyzer is dedicated to analysis that is not particularly urgent, prioritize display of analysis results by the analyzer, and prioritize display of time until processing is completed by the existing analyzer. You may make it set lower than an order | rank.

  In the above description, the analysis apparatus 1 configured to receive the cartridge 20 at a plurality of locations and perform analysis processing on the cartridge 20 in parallel has been described. However, the present invention is configured to receive only one cartridge 20. The present invention can be similarly applied to other analyzers. That is, even in an analyzer having such a configuration, if other analyzers are added to it, the display may be confused. Therefore, by applying the present invention, the occurrence of such a problem can be prevented. Can do.

  The items related to the measurement will be briefly described below.

(Sample solution)
The sample solution that can be analyzed using the analyzer of the present invention is as long as it may contain a test substance (natural products, toxins, hormones, physiologically active substances such as agricultural chemicals, environmental pollutants, etc.). For example, biological samples, especially animal (especially human) body fluids (eg blood, serum, plasma, spinal fluid, tears, sweat, urine, pus, runny nose or sputum) ) Or excrement (for example, feces), organs, tissues, mucous membranes and skin, overwhelmed specimens (swabs), gargles, or animals and plants themselves or their dried bodies, which are considered to contain them, are diluted with a diluent described below. Can be mentioned.

  Leave the sample solution as it is, or in the form of an extract obtained by extracting the sample solution with an appropriate extraction solvent, and further dilute this extract with an appropriate diluent. It can be used in the form or the extract concentrated by an appropriate method.

(Labeling substance)
As a labeling substance that can be used in the present invention, metal fine particles (or metal colloids), colored latex particles, enzymes, etc., which are used in general immunochromatography, can be visually confirmed or can be inspected by reaction. It can be used without any particular limitation as long as it is a labeled substance, but when a signal is sensitized by metal deposition on the labeling substance by a reduction reaction of metal ions using the labeling substance as a catalyst, From the viewpoint of catalytic activity, metal fine particles are preferred.

  As the material of the metal fine particles, a metal simple substance, metal sulfide, other metal alloy, or polymer particle label containing metal can be used. The average particle size of the particles (or colloid) is preferably in the range of 1 nm to 10 μm. Here, the average particle diameter is an average value of the diameters of the plurality of particles (the longest diameter of the particles) measured by a transmission electron microscope (TEM). More specifically, gold colloids, silver colloids, platinum colloids, iron colloids, aluminum hydroxide colloids, composite colloids thereof, and the like are preferable. Gold colloids, silver colloids, platinum colloids, and composite composite colloids thereof are preferable. It is desirable to be. In particular, gold colloid and silver colloid are suitable in terms of appropriate particle diameters, and gold colloid is red and silver colloid is yellow, which is more preferable in view of high visibility. By using a gold colloid, the sensitization process using a silver ion-containing compound changes the chromaticity of the label before and after the sensitization (the gold colloid is colored red, and after the sensitization, the reduced silver Since the ions are deposited on the gold colloid and become black), this change can be used for error determination of the inspection as will be described later. The average particle size of the metal colloid is preferably about 1 to 500 nm, more preferably 1 to 100 nm.

(Specific binding substance)
The specific binding substance is not particularly limited as long as it has affinity for the test substance. For example, when the test substance is an antigen, an antibody against the antigen, the test substance is a protein, a metal ion Alternatively, aptamers for low molecular weight organic compounds, and when the test substance is a nucleic acid such as DNA or RNA, nucleic acid molecules such as DNA or RNA having a sequence complementary thereto, or the test substance is avidin. In some cases, biotin, and in the case where the test substance is a specific peptide, a complex that specifically binds to this can be used. In the above example, the relationship between the specific binding substance and the test substance can be exchanged. For example, when the test substance is an antibody, an antigen against the antibody can be used as the specific binding substance. Furthermore, a compound or the like partially containing a substance having affinity for the test substance as described above can also be used as the specific binding substance.

  Specific examples of the antibody include antiserum prepared from the serum of an animal immunized with the test substance, an immunoglobulin fraction purified from the antiserum, and cell fusion using spleen cells of the animal immunized with the test substance Or a fragment thereof [for example, F (ab ′) 2, Fab, Fab ′, or Fv] can be used. These antibodies can be prepared by a conventional method.

(Insoluble carrier)
The material of the insoluble carrier 21 is preferably porous, for example, a nitrocellulose membrane, a cellulose membrane, an acetylcellulose membrane, a polysulfone membrane, a polyethersulfone membrane, a nylon membrane, glass fiber, a nonwoven fabric, a cloth, or a thread. Preferably mentioned.

  On the chromatographic carrier, a specific binding substance for the test substance is immobilized, and a test site or a control site is produced if desired. The specific binding substance may be directly immobilized on a part of the chromatographic carrier by physical or chemical binding, or the specific binding substance may be physically or chemically attached to fine particles such as latex particles. The fine particles may be trapped on a part of the chromatographic carrier and immobilized.

(Sensitizer)
The sensitizing solution is a solution capable of causing a signal sensitization by producing a colored or luminescent compound or the like when a contained drug reacts by a catalytic action of a labeling substance or a test substance. For example, a silver ion solution that causes metal silver to be deposited by physical development on a metal label. Details include general books in the field of photographic chemistry (for example, “Basics of Revised Photo Engineering-Silver Salt Photo Edition” (Japan Photographic Society, Corona), “Photochemistry” (Akira Sakurai, Photo Industry Publishing) ), “Latest Prescription Handbook” (Shinichi Kikuchi et al., Amico Publishing Co., Ltd.)), so-called developers can be used. For example, when a physical developer containing a silver ion-containing compound is used as a sensitizer, silver ions in the solution can be reduced mainly by a metal colloid or the like that serves as a development nucleus by a silver ion reducing agent. .

As another example, an enzyme reaction is used. For example, a solution of a phenylenediamine compound and a naphthol compound, which becomes a dye by the action of a peroxidase label and hydrogen peroxide, can be used. Further, it may be a chromogenic substrate for detecting horseradish peroxidase as described in the non-patent document “Staining using clinical test Vol. 41 no. 9 p. 1020 H ₂ O ₂ -POD system”. In addition, the chromogenic substrate described in JP2009-156612A can be particularly preferably used. A system using a metal catalyst such as platinum fine particles instead of the enzyme may be used.

  As an example using another enzyme, there is a system in which alkaline phosphatase is used as a label and color is developed using 5-bromo-4chloro-3-indolyl-phosphate disodium salt (BCIP) as a substrate. As described above, the reaction that gives a color is given as a representative, but any combination of enzyme and substrate, such as those generally used in enzyme immunoassays, may be used, and even a chemiluminescent substrate is a substrate that emits fluorescence. May be.

(Silver ion-containing compound)
As the silver ion-containing compound, an organic silver salt, an inorganic silver salt, or a silver complex can be used. Preferably, it is a silver ion-containing compound having high solubility in a solvent such as water, and examples thereof include silver nitrate, silver acetate, silver lactate, silver butyrate, and silver thiosulfate. Particularly preferred is silver nitrate. The silver complex is preferably a silver complex coordinated to a ligand having a water-soluble group such as a hydroxyl group or a sulfone group, and examples thereof include hydroxythioether silver. The inorganic silver salt or silver complex is generally contained as silver in an amount of 0.001 mol / m ^{2 to} 0.2 mol / m ² , preferably 0.01 mol / m ^{2 to} 0.05 mol / m ^2. preferable.

(Silver ion reducing agent)
As the silver ion reducing agent, any inorganic or organic material or a mixture thereof can be used as long as it can reduce silver ions to silver.

Preferred examples of the inorganic reducing agent include reducible metal salts and reducible metal complex salts whose valence can be changed by metal ions such as Fe ²⁺ , V ²⁺ , and Ti ³⁺ . When using an inorganic reducing agent, it is necessary to complex or reduce the oxidized ions to remove or render them harmless. For example, in a system using Fe ²⁺ as a reducing agent, a complex of Fe ³⁺ that is an oxide can be formed using citric acid or EDTA, and can be rendered harmless. In this system, it is preferable to use such an inorganic reducing agent, and more preferable is a metal salt of Fe ²⁺ .

  In the above-described embodiment, a method of sensitizing a labeling substance by reducing a silver ion-containing compound with a reducing agent is used as a sensitizing method in a colored state, but the sensitizing method in the present invention is limited to this. Not. The sensitizing solution may be any solution that can cause a signal sensitization by generating a colored or luminescent compound by reacting the contained drug by the catalytic action of a labeling substance or a test substance. And liquids using such enzymes.

  Moreover, in the said embodiment, although the immunochromatography method was demonstrated as an assay method, the assay method applied by this invention is not limited to this. A system that does not use a so-called immune reaction may be used, for example, a system that captures a test substance with a nucleic acid such as DNA or RNA without using an antibody, or another small molecule or peptide that has an affinity for the test substance, A system in which a test substance is captured by a protein, a complex-forming substance, or the like may be used.

DESCRIPTION OF SYMBOLS 1 Analyzer 10 Case 11 Display part 12 Operation part 13 Power switch 14 Cartridge loading part 20 Immunochromatography cartridge 21 Insoluble carrier 22 Cartridge case 23 Solution inlet 26 Sheet material 27 Washing liquid pot 28 Sensitizing liquid pots 30 and 34 Pressing part 32, 36 Pressing piece 33, 37 Cam 38 Motor 40, 50 Measuring unit 87, 88 Blade 80 Control unit 90 Sample solution 91 Cleaning solution 92 Sensitizing solution 102 Battery 103 Battery capacity monitoring unit 150, 151 Extension cable 200, 300 Extension cable 200, 300 Analyzer A, B Test line C Control line U Measuring unit

Claims (4)

A display unit;
A display control unit that displays a plurality of display items related to analysis on the display unit in accordance with a predetermined priority order defined in advance in the form of a table;
In analyzers that can be expanded with other analyzers that do not have a display,
A display control method for an analyzer, wherein when the other analyzer is added, the table is updated so that the priority is reset by adding display items related to analysis in the analyzer.   When the display items related to the analysis in the other analyzer are the same as the plurality of display items whose priority is defined by the table, the priority of the former display item is set to the priority of the latter display item. 2. The display control method for an analyzer according to claim 1, wherein the table is updated in accordance with a rank. A display unit;
A display control unit that displays a plurality of display items related to analysis on the display unit in accordance with a predetermined priority order defined in advance in the form of a table;
In analyzers that can be expanded with other analyzers that do not have a display,
The display control unit is configured to perform table update processing for resetting the priority order in addition to display items related to analysis in the analysis device when the other analysis device is added. Characteristic analyzer.   When the display items related to the analysis in the other analyzer are the same as the plurality of display items whose priority is defined by the table, the priority of the former display item is set to the priority of the latter display item. The analysis apparatus according to claim 3, wherein the display control unit is configured to match the rank.

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