JP2012075670A - Cuff electrode - Google Patents

Cuff electrode Download PDF

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JP2012075670A
JP2012075670A JP2010223455A JP2010223455A JP2012075670A JP 2012075670 A JP2012075670 A JP 2012075670A JP 2010223455 A JP2010223455 A JP 2010223455A JP 2010223455 A JP2010223455 A JP 2010223455A JP 2012075670 A JP2012075670 A JP 2012075670A
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cuff electrode
nerve
slit
tongue piece
electrode
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Japanese (ja)
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Shinichi Ito
眞一 伊藤
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Shimane University
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Shimane University
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  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Electrotherapy Devices (AREA)

Abstract

PROBLEM TO BE SOLVED: To provide a cuff electrode that can easily embed nerves in spite of being small without pressing the nerves so as to hardly come off.SOLUTION: The cuff electrode 100 of substantially cylindrical shape includes, in the surface, a penetrating slit 111 oblique to an axis, and embeds the nerves into the cylindrical body 101. The slit 111 is formed in crest shape to form a tongue piece 113, and the nerves can be embedded from the tongue piece 113.

Description

本発明は、カフ電極に関し、特に、神経を容易に抱え込むことが可能で抜けにくいカフ電極に関する。   The present invention relates to a cuff electrode, and more particularly to a cuff electrode that can easily hold a nerve and is not easily removed.

カフ電極は動物実験における末梢神経の活動記録や電気刺激のためのチューブ状の埋め込み電極である。詳細にはシリコンなどの非導電性のチューブの内面に白金線などの金属線を這わせ、神経を抱くように包み込み、この金属線を神経に接触させて記録ないし刺激をおこなう。   The cuff electrode is a tube-shaped implanted electrode for recording peripheral nerve activities and electrical stimulation in animal experiments. Specifically, a metal wire such as a platinum wire is placed on the inner surface of a non-conductive tube such as silicon, and is wrapped so as to hold a nerve, and this metal wire is brought into contact with the nerve for recording or stimulation.

カフ電極は、チューブの軸に沿って表面に縦に切れ込みが入れられ、ここから神経を埋入し、ひも状の神経を抱かせる。   The cuff electrode is vertically cut on the surface along the axis of the tube, from which the nerve is implanted and the string-like nerve is held.

しかしながら、従来の技術では以下の問題点があった。
従来のカフ電極は、神経の飛び出しを防ぐため、切れ込みの幅を狭くしている。しかしながら、カフ電極はその構造上、相対的に肉厚のシリコンチューブをベースとすることが多く、圧迫に極めて弱い神経組織を幅の狭い切れ込みを介して押し込むのは、神経を痛める場合があるという問題点があった。
However, the conventional technique has the following problems.
In the conventional cuff electrode, the width of the cut is narrowed in order to prevent the nerve from jumping out. However, the cuff electrode is often based on a relatively thick silicon tube because of its structure, and pushing a nerve tissue that is extremely vulnerable to compression through a narrow cut may damage the nerve. There was a problem.

一方、切れ込みの幅を広くすると、長期間の観測や、体位を変化させる場合など、切れ込みから神経が飛び出すという問題点もあった。   On the other hand, if the width of the cut was widened, there was a problem that the nerve jumped out of the cut, such as when observing for a long period of time or changing the body position.

また、幅の広い切れ込みをいれて、神経を埋入後、切れ込みを糸で縫合する方式のものがあるが、マウスやラットなどの小型動物では神経も細く、顕微鏡下での作業となる場合もあり、必ずしも簡便な装着とならないという問題点があった。   In addition, there is a method in which a wide incision is made and the nerve is implanted, and then the incision is sutured with a thread. However, in small animals such as mice and rats, the nerve is also thin and may be work under a microscope. There is a problem that it is not always easy to wear.

特表2006−521861Special table 2006-521861

内野 善生ら「ネコの手術・実験法」日生誌 Vol.63, No.10 2001 pp271-316Yoshio Uchino et al. "Surgery and Experimental Methods for Cats" Nissay Magazine Vol.63, No.10 2001 pp271-316

本発明は、上記に鑑みてなされたものであって、神経を圧迫することなく小型であっても簡便に埋入が可能で、外れにくいカフ電極を提供することを目的とする。   The present invention has been made in view of the above, and an object of the present invention is to provide a cuff electrode that can be easily embedded even if it is small without pressing a nerve and is difficult to come off.

請求項1に記載のカフ電極は、略円筒形であって、軸に対して斜めに形成されたスリットを表面に設け、神経を円筒内に埋入可能にしたことを特徴とする。   The cuff electrode according to claim 1 is substantially cylindrical, and is characterized in that a slit formed obliquely with respect to the axis is provided on the surface so that nerves can be embedded in the cylinder.

すなわち、請求項1にかかる発明は、神経が径方向(軸に対して外側)に移動しようとしても、事実上円筒内面が邪魔をする結果、スリット幅を相対的に広くでき、神経を圧迫することなく簡便に埋入が可能で、外れにくいカフ電極を提供することができる。   That is, in the invention according to claim 1, even if the nerve tries to move in the radial direction (outside with respect to the axis), as a result of the fact that the inner surface of the cylinder effectively interferes, the slit width can be made relatively wide and the nerve is compressed. Therefore, it is possible to provide a cuff electrode that can be easily embedded without being easily detached.

なお、円筒形状は、対象となる神経の太さに応じて種々変更することが可能である。また、素材はたとえば円筒部分はシリコン、電極部分は白金とすることができるがこれに限定されない。また、スリット幅は、埋入作業の際、神経を圧迫しすぎない太さ、例えば神経程度の太さとすることができる。スリットを斜めにするのは一部であっても良く、一端から他端まで斜めとしても良い。なお、周面上に斜めに一直線のスリットである場合は、スリットは、螺旋を描くこととなる。   The cylindrical shape can be variously changed according to the thickness of the target nerve. The material may be silicon for the cylindrical portion and platinum for the electrode portion, but is not limited thereto. Further, the slit width can be set to a thickness that does not overstress the nerve during the embedding operation, for example, a thickness about the nerve. A part of the slit may be slanted, or may be slanted from one end to the other end. In addition, when it is a linear slit diagonally on a surrounding surface, a slit will draw a spiral.

請求項2に記載のカフ電極は、請求項1に記載のカフ電極において、スリットが、山なりの曲線を描き、少なくとも一つの舌片を形成したことを特徴とする。   A cuff electrode according to a second aspect is characterized in that, in the cuff electrode according to the first aspect, the slit has a mountain-shaped curve to form at least one tongue piece.

すなわち、請求項2にかかる発明は、神経の飛び出しを効果的に抑制可能となる。また、舌片により神経を引っかけるようにして簡便に埋入することも可能となる。なお、山なりの曲線とは、一山に限定されず、S字であっても、V字、W字であっても良い。従って、舌片の形状は半円形に限定されず、山形の他、台形であっても良い。   That is, the invention according to claim 2 can effectively suppress the jumping out of the nerve. In addition, it is possible to simply embed it by hooking a nerve with a tongue piece. The mountain curve is not limited to one mountain, and may be S-shaped, V-shaped, or W-shaped. Therefore, the shape of the tongue piece is not limited to a semicircular shape, and may be a trapezoidal shape as well as a mountain shape.

請求項3に記載のカフ電極は、請求項2に記載のカフ電極において、一つの舌片が形成され、電極用導線が舌片の延伸方向の円筒周面から延設されていることを特徴とする。   The cuff electrode according to claim 3 is the cuff electrode according to claim 2, wherein one tongue piece is formed, and the electrode lead wire is extended from a cylindrical peripheral surface in the extending direction of the tongue piece. And

すなわち、請求項3にかかる発明は、導線部分をつまんでカフ電極を保持しやすくなり、舌片やスリット間隙を介して神経を簡便に円筒内に埋入可能となる。   That is, in the invention according to claim 3, it becomes easy to hold the cuff electrode by pinching the lead wire portion, and the nerve can be easily embedded in the cylinder via the tongue piece or the slit gap.

本発明によれば、神経を圧迫することなく小型であっても簡便に埋入が可能で、外れにくいカフ電極を提供することが可能となる。
According to the present invention, it is possible to provide a cuff electrode that can be easily embedded even if it is small without pressing a nerve and is difficult to come off.

本発明のカフ電極の一実施の形態を示した概要図である。It is the schematic which showed one Embodiment of the cuff electrode of this invention. カフ電極の円筒体の他の構成例を示した図である。It is the figure which showed the other structural example of the cylindrical body of a cuff electrode.

以下、本発明の実施の形態を図面を参照しながら詳細に説明する。
図1は、本発明のカフ電極の一実施の形態を示した概要図である。図示したように、カフ電極100は、略円筒形の円筒体101と、電極102とを有する。
Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.
FIG. 1 is a schematic view showing an embodiment of the cuff electrode of the present invention. As shown in the figure, the cuff electrode 100 includes a substantially cylindrical body 101 and an electrode 102.

図示したように、円筒体101は、スリット111が設けられ、神経を円筒体101内部に導入できるようになっている。スリット111は、左右の端部112から筒長さの約1/3まで円筒軸に平行な切れ込みであり、そこから円筒軸に斜めに滑らかかつ対称にせり上がり山なりとなった切れ込みとしている。これにより円筒体101には、舌片113が形成されることとなる。   As shown in the figure, the cylindrical body 101 is provided with a slit 111 so that nerves can be introduced into the cylindrical body 101. The slit 111 is a cut parallel to the cylindrical axis from the left and right end portions 112 to about 3 of the cylinder length, and is formed into a notch that rises smoothly and symmetrically to the cylindrical axis and becomes a mountain. As a result, the tongue piece 113 is formed on the cylindrical body 101.

円筒体101の素材は、特に限定されないが、シリコン素材であれば柔軟であり埋入作業も容易となり、長期間体内に埋め込む場合であっても、異物反応が出にくく好適である。   The material of the cylindrical body 101 is not particularly limited, but if it is a silicon material, it is flexible and the embedding work is facilitated.

円筒体101の大きさは、特に限定されないが、例えば、内径を0.5mm〜2mm、外形を0.8mm〜3.0mm、筒長さを、4mm〜15mmとすることができる。   Although the magnitude | size of the cylindrical body 101 is not specifically limited, For example, an internal diameter can be 0.5 mm-2 mm, an external shape can be 0.8 mm-3.0 mm, and cylinder length can be 4 mm-15 mm.

電極102は、円筒体101内周面に露出させる様に配置し(図示せず)、円筒体101外部に延伸し導線121と接合させる。なお、導線121を含み、円筒体101外部の金属部分は適宜被膜するものとする。また、導線121は、スリット111をはさんで舌片113と対向する円筒体101部分から外部に延伸させるようにする。すなわち、舌片113の延伸方向の円筒側周から延設させるようにする。これにより保持性が高まり、神経を簡便に挿入させることができる。なお、使用の態様により、舌片113から導線121を延伸させるようにしてもよい。   The electrode 102 is disposed so as to be exposed on the inner peripheral surface of the cylindrical body 101 (not shown), and is extended to the outside of the cylindrical body 101 and joined to the conducting wire 121. In addition, the metal part including the conducting wire 121 and the cylindrical body 101 outside shall be appropriately coated. Further, the conducting wire 121 is extended outside from the cylindrical body 101 portion facing the tongue piece 113 with the slit 111 interposed therebetween. That is, the tongue piece 113 is extended from the cylindrical side periphery in the extending direction. As a result, the retainability is enhanced and the nerve can be easily inserted. In addition, you may make it extend the conducting wire 121 from the tongue piece 113 with the aspect of use.

電極102の素材は、白金、銀、金、銅、ニクロム線などを用いることができ、体液等との反応性が低いものが好ましく、白金が使用実績もあり好適である。なお、導線121は電極102と同素材としてもよい。なお、本実施の形態では、電極102および導線121は一対としているが、必要に応じて適宜数を調整することもできる。二本であれば記録と刺激が可能であり、4〜5本であれば、刺激と記録を同時におこなうことができる。   As a material for the electrode 102, platinum, silver, gold, copper, nichrome wire, or the like can be used, and a material having low reactivity with a body fluid or the like is preferable. The conducting wire 121 may be made of the same material as the electrode 102. In the present embodiment, the electrode 102 and the conductive wire 121 are paired, but the number can be adjusted as necessary. If there are two, recording and stimulation are possible, and if there are four to five, stimulation and recording can be performed simultaneously.

神経組織を円筒体101に埋入し抱持させる場合には、まず、対象となる神経にカフ電極100を沿わせ、次に、導線121を持ち、場合によっては、ピンセット等を用い、カフ電極100の姿勢を制御しながらスリット111の端部から神経を掛けるようにして順次スリット111に沿って埋入を完了する。相対的に肉厚のシリコン素材である場合には舌片113をめくりあげることはできないが、柔軟な素材の場合には、舌片を持ち上げて神経を埋入することもできる。   In order to embed and hold a nerve tissue in the cylindrical body 101, first, the cuff electrode 100 is placed along the target nerve, and then the lead 121 is provided. Embedding is sequentially completed along the slit 111 so that the nerve is applied from the end of the slit 111 while controlling the posture of 100. In the case of a relatively thick silicon material, the tongue piece 113 cannot be turned up, but in the case of a flexible material, the tongue piece can be lifted to embed nerves.

以上説明したように、舌片113を介し神経を容易にカフ電極100内部に抱え込ませることができる。反対に、舌片113が邪魔をするため、神経が外部に飛び出してしまう(カフ電極100が神経から外れてしまう)ことが防止される。   As described above, the nerve can be easily held inside the cuff electrode 100 via the tongue piece 113. On the contrary, since the tongue piece 113 interferes, the nerve is prevented from jumping out (the cuff electrode 100 is detached from the nerve).

なお、スリット111の形状は図1に示したものに限定されない。図2は、円筒体101の他の形態を示した概要図である。図2(a)は、S字スリット、図2(b)は、波形スリット、図2(c)は、V字スリット、図2(d)は、ジグザグスリット、図2(e)は、矩形スリットを示している。神経は直線状であるので円筒軸に斜めなスリットとすれば、容易な埋入を実現しつつ、外れにくいカフ電極の提供が可能となる。特に、図2(f)に示したように、舌片を延伸方向に広がる形状とすれば、さらに神経が外れにくくなる。また、図2(g)に示したように、スリットを直線状にして円筒面上で周回させる螺旋形状とすることもできる。   The shape of the slit 111 is not limited to that shown in FIG. FIG. 2 is a schematic view showing another form of the cylindrical body 101. 2A is an S-shaped slit, FIG. 2B is a corrugated slit, FIG. 2C is a V-shaped slit, FIG. 2D is a zigzag slit, and FIG. 2E is a rectangular shape. A slit is shown. Since the nerve is linear, if the slit is inclined to the cylindrical axis, it is possible to provide a cuff electrode that is easy to embed and does not easily come off. In particular, as shown in FIG. 2 (f), if the tongue piece has a shape that expands in the extending direction, the nerve becomes more difficult to come off. Moreover, as shown in FIG.2 (g), it can also be set as the spiral shape which makes a slit linear and it circulates on a cylindrical surface.

カフ電極を用いることにより、電気刺激だけでなく、治療研究の基礎とすることもできる。   By using cuff electrodes, it can be used as a basis for therapeutic research as well as electrical stimulation.

100 カフ電極
101 円筒体
102 電極
111 スリット
112 端部
113 舌片
121 導線

100 Cuff electrode 101 Cylindrical body 102 Electrode 111 Slit 112 End 113 Tongue piece 121 Conductor

Claims (3)

略円筒形であって、軸に対して斜めに形成されたスリットを表面に設け、神経を円筒内に埋入可能にしたことを特徴とするカフ電極。   A cuff electrode having a substantially cylindrical shape and provided with slits formed obliquely with respect to an axis on a surface thereof so that nerves can be embedded in the cylinder. スリットは、山なりの曲線を描き、少なくとも一つの舌片を形成したことを特徴とする請求項1に記載のカフ電極。   The cuff electrode according to claim 1, wherein the slit draws a mountain-shaped curve to form at least one tongue piece. 一つの舌片が形成され、電極用導線が舌片の延伸方向の円筒周面から延設されていることを特徴とする請求項2に記載のカフ電極。
The cuff electrode according to claim 2, wherein one tongue piece is formed, and the electrode conducting wire is extended from a cylindrical peripheral surface in the extending direction of the tongue piece.
JP2010223455A 2010-10-01 2010-10-01 Cuff electrode Pending JP2012075670A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016501686A (en) * 2012-12-28 2016-01-21 カーディアック ペースメイカーズ, インコーポレイテッド Stimulation cuff and implantable device
US9452283B2 (en) 2013-02-13 2016-09-27 Cardiac Pacemakers, Inc. Cuff electrode with integrated tendril

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016501686A (en) * 2012-12-28 2016-01-21 カーディアック ペースメイカーズ, インコーポレイテッド Stimulation cuff and implantable device
US9452283B2 (en) 2013-02-13 2016-09-27 Cardiac Pacemakers, Inc. Cuff electrode with integrated tendril

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