JP2012071051A - Transfusion container - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a transfusion container which can show excellent oxygen absorption performance even without containing neither iron powder nor a transition metal compound etc., in a container wall, keep the oxygen inside the container at an extremely low concentration for a long term, and is suitable as the container for a transfusion preparation containing a component to be easily transformed by contact with oxygen.SOLUTION: The transfusion container is constituted of a single-layer or multi-layer container wall having an oxygen absorption resin layer which contains an oxygen absorption resin composition containing a conjugated diene polymer cyclized product.

Description

  The present invention relates to an infusion container, and more particularly, contains components that are easily altered by contact with oxygen, such as amino acid infusion preparations and fat emulsions, because the oxygen inside the container can be kept at a very low concentration over a long period of time. The present invention relates to an infusion container suitably used as a container for an infusion preparation.

  Among the infusion preparations, amino acid infusion preparations and fat emulsions are known to be easily denatured by their components (for example, cysteine and linoleic acid) upon contact with oxygen. An infusion container made of a material having oxygen absorbability has been proposed as a container for an infusion preparation containing a component that is easily altered by contact with oxygen.

  For example, Patent Document 1 proposes a plastic multi-chamber infusion container having an oxygen-absorbing resin inner layer formed by mixing iron powder or sulfite with polyolefin resin. According to this plastic multi-chamber infusion container, it is said that oxidative decomposition of the infusion agent can be prevented over a long period of time. However, in the multi-chamber infusion container of Patent Document 1, when an oxygen-absorbing resin inner layer formed by mixing iron powder with polyolefin resin is used, metal foreign object inspection using a metal detector is applied to the obtained infusion container. There is a problem that it is difficult to ensure transparency of the container. Moreover, in the multi-chamber infusion container of Patent Document 1, when an oxygen-absorbing resin inner layer obtained by mixing sulfite with a polyolefin resin is used, it becomes difficult to ensure the transparency of the container, and it is used for medical purposes. There are safety concerns in some cases.

  Moreover, in patent document 2, the container for infusion comprised using the resin layer which has oxygen supplementary resin formed by mix | blending transition metal compounds, such as cobalt stearate, with the specific resin by which the olefin oligomer segment was couple | bonded. Proposed. According to this infusion container, it is possible to remove dissolved oxygen in the infusion container, and since it has excellent oxygen barrier properties, it is possible to store infusions containing components that are easily altered by contact with oxygen for a long period of time. It is supposed to be. However, in the infusion container described in Patent Document 2, it is essential to blend a transition metal compound such as cobalt stearate in order to make the resin exhibit sufficient oxygen absorption capacity. There is a safety concern when used as a medical application in that it needs to be formulated.

JP-A-7-155361 JP 2001-46474 A

  The present invention can exhibit excellent oxygen absorption performance without containing iron powder or transition metal compound in the container wall, and keeps the oxygen inside the container at a very low concentration over a long period of time. An object of the present invention is to provide an infusion container that can be used.

  As a result of intensive studies to achieve the above object, the inventors of the present invention comprise an oxygen-absorbing resin composition containing at least one conjugated diene polymer cyclized product in the container wall of the infusion container. It has been found that the above-mentioned object can be achieved by configuring with an oxygen-absorbing resin layer. The present invention has been completed based on this finding.

  Thus, according to the present invention, an infusion container constituted by a single-layer or multi-layer container wall, the container wall comprising an oxygen-absorbing resin composition containing a conjugated diene polymer cyclized product. An infusion container characterized by having a conductive resin layer is provided.

  In the above infusion container, the oxygen-absorbing resin layer is preferably a layer obtained by dispersing an oxygen-absorbing resin composition containing a conjugated diene polymer cyclized product and a softening agent in a matrix resin.

  In said infusion container, it is preferable that a container wall consists only of a layer which does not contain a heavy metal component substantially.

  In said infusion container, it is preferable that a container wall is a multilayer container wall which further has a heat-sealable resin layer.

  According to the present invention, it is possible to exhibit excellent oxygen absorption performance without containing iron powder or a transition metal compound in the container wall, and the oxygen inside the container can be kept at a very low concentration over a long period of time. An infusion container that can be maintained is obtained.

  The infusion container of the present invention is an infusion container constituted by a single-layer or multilayer container wall, and the container wall contains an oxygen-absorbing resin composition containing a conjugated diene polymer cyclized product. It has a resin layer. The container wall in the infusion container of the present invention may have a single layer structure or a multilayer structure, but includes an oxygen-absorbing resin composition containing at least one conjugated diene polymer cyclized product. It is necessary to have an oxygen-absorbing resin layer.

  In the oxygen-absorbing resin composition that is at least part of the material constituting the oxygen-absorbing resin layer, the conjugated diene polymer cyclized product used as an active ingredient for oxygen absorption is the presence of an acid catalyst in the conjugated diene polymer. It is obtained by cyclization reaction below, has a ring structure in the molecule, and has at least one double bond in the ring structure.

  The conjugated diene polymer used for obtaining the conjugated diene polymer cyclized product includes a conjugated diene monomer homopolymer, a copolymer of two or more conjugated diene monomers, and a conjugated diene monomer. Copolymers with other monomers copolymerizable with this can be used. The conjugated diene monomer is not particularly limited, and specific examples thereof include 1,3-butadiene, isoprene, 2,3-dimethyl-1,3-butadiene, 2-phenyl-1,3-butadiene, 1, Examples include 3-pentadiene, 2-methyl-1,3-pentadiene, 1,3-hexadiene, 4,5-diethyl-1,3-octadiene, and 3-butyl-1,3-octadiene. These monomers may be used individually by 1 type, and may be used in combination of 2 or more type.

  Examples of other monomers copolymerizable with the conjugated diene monomer include styrene, o-methylstyrene, p-methylstyrene, m-methylstyrene, 2,4-dimethylstyrene, ethylstyrene, and p-tert. Fragrances such as butyl styrene, α-methyl styrene, α-methyl-p-methyl styrene, o-chloro styrene, m-chloro styrene, p-chloro styrene, p-bromo styrene, 2,4-dibromo styrene, vinyl naphthalene Group vinyl monomers, chain olefin monomers such as ethylene, propylene and 1-butene, cyclic olefin monomers such as cyclopentene and 2-norbornene, 1,5-hexadiene, 1,6-heptadiene, 1,7 Non-conjugated diene monomers such as octadiene, dicyclopentadiene, 5-ethylidene-2-norbornene, ( Examples include (meth) acrylic acid esters such as methyl (meth) acrylate and ethyl (meth) acrylate, and other (meth) acrylic acid derivatives such as (meth) acrylonitrile and (meth) acrylamide. These monomers may be used individually by 1 type, and may be used in combination of 2 or more type. Further, the copolymerization mode is not particularly limited, and may be, for example, a block copolymer or a random copolymer.

  Specific examples of the conjugated diene polymer include natural rubber (NR), styrene-isoprene rubber (SIR), styrene-butadiene rubber (SBR), polyisoprene rubber (IR), polybutadiene rubber (BR), isoprene-isobutylene copolymer. Examples thereof include a combined rubber (IIR), an ethylene-propylene-diene copolymer rubber (EPDM), a butadiene-isoprene copolymer rubber (BIR), a styrene-isoprene block polymer, and a styrene-butadiene block polymer. Among these, polyisoprene rubber, polybutadiene rubber, and styrene-isoprene block polymer are preferably used, polyisoprene rubber and styrene-isoprene block polymer are more preferably used, and polyisoprene rubber is most preferably used. These conjugated diene polymers may be used individually by 1 type, and may be used in combination of 2 or more type.

  The content of the conjugated diene monomer unit in the conjugated diene polymer is not particularly limited, but is usually 40 mol% or more, preferably 60 mol% or more, more preferably 80 mol% or more. The production method of the conjugated diene polymer may be in accordance with a conventional method. For example, using a suitable catalyst such as a Ziegler polymerization catalyst, an alkyl lithium polymerization catalyst, or a radical polymerization catalyst, a conjugated diene polymer may be produced by a solution polymerization method or an emulsion polymerization method. By polymerizing the monomer, a conjugated diene polymer can be obtained. A conjugated diene polymer obtained by polymerization with a Ziegler polymerization catalyst and then metathesis decomposition using a catalyst such as ruthenium or tungsten can also be used.

  The microstructure of the conjugated diene polymer is not particularly limited. For example, when polyisoprene rubber is used as the conjugated diene polymer, the cis-1,4-bond unit content is preferably 23 to 99%, and the trans-1,4-bond unit content is 1 to 28. %, And the 3,4-bond unit content is preferably 0 to 55%.

  The conjugated diene polymer cyclized product can be obtained by subjecting the conjugated diene polymer as described above to a cyclization reaction in the presence of an acid catalyst. Known acid catalysts can be used for the cyclization reaction. Specific examples thereof include sulfuric acid; fluoromethanesulfonic acid, difluoromethanesulfonic acid, p-toluenesulfonic acid, xylenesulfonic acid, alkylbenzenesulfonic acid having an alkyl group having 2 to 18 carbon atoms, anhydrides and alkyl esters thereof, and the like. Organic sulfonic acid compounds: boron trifluoride, boron trichloride, tin tetrachloride, titanium tetrachloride, aluminum chloride, diethylaluminum monochloride, ethylammonium chloride, aluminum bromide, antimony pentachloride, tungsten hexachloride, iron chloride, etc. A Lewis acid. These acid catalysts may be used alone or in combination of two or more. Moreover, you may use together a tertiary butyl chloride and a trichloroacetic acid as a promoter. Among these, an organic sulfonic acid compound is preferably used, and p-toluenesulfonic acid and xylenesulfonic acid are more preferably used. The usage-amount of an acid catalyst is 0.05-10 weight part normally per 100 weight part of conjugated diene polymers, Preferably it is 0.1-5 weight part, More preferably, it is 0.3-2 weight part.

  The cyclization reaction is usually performed by dissolving the conjugated diene polymer in a solvent. The solvent is not particularly limited as long as it does not inhibit the cyclization reaction, but is an aromatic hydrocarbon such as benzene, toluene, xylene, ethylbenzene; n-pentane, n-hexane, n-heptane, n-octane, etc. Hydrocarbon solvents such as aliphatic hydrocarbons; alicyclic hydrocarbons such as cyclopentane and cyclohexane; are preferably used. The boiling point of these hydrocarbon solvents is preferably 70 ° C. or higher. The solvent used for the polymerization reaction of the conjugated diene polymer and the solvent used for the cyclization reaction may be of the same type. In this case, an acid catalyst for cyclization reaction can be added to the polymerization reaction solution after completion of the polymerization reaction, and the cyclization reaction can be carried out following the polymerization reaction. The amount of the hydrocarbon solvent used is such that the solid content concentration of the conjugated diene polymer is usually 5 to 60% by weight, preferably 20 to 40% by weight.

  The cyclization reaction can be performed under pressure, reduced pressure, or atmospheric pressure, but is preferably performed under atmospheric pressure from the viewpoint of ease of operation. When the cyclization reaction is performed in a dry air flow, particularly in an atmosphere of dry nitrogen or dry argon, side reactions caused by moisture can be suppressed. The reaction temperature and reaction time in the cyclization reaction are not particularly limited. The reaction temperature is usually 50 to 150 ° C., preferably 70 to 110 ° C., and the reaction time is usually 0.5 to 10 hours, preferably 2 to 5 hours. After carrying out the cyclization reaction, the acid catalyst is inactivated, the acid catalyst residue is removed, and then the hydrocarbon solvent is removed by a conventional method to obtain a solid conjugated diene polymer cyclized product.

  The unsaturated bond reduction rate of the conjugated diene polymer cyclized product is not particularly limited, but is preferably 40% or more, more preferably 52 to 70%, and 59 to 65%. Is particularly preferred. By using a conjugated diene polymer cyclized product having an unsaturated bond reduction rate in such a range, the oxygen-absorbing resin composition can be provided with good oxygen-absorbing performance, and the odor associated with oxygen absorption can be reduced. Occurrence can be suppressed. In addition, as the conjugated diene polymer cyclized product, two or more conjugated diene polymer cyclized products having different unsaturated bond reduction rates may be used in combination.

  The unsaturated bond reduction rate of the conjugated diene polymer cyclized product is an index representing the degree to which the unsaturated bond is reduced by the cyclization reaction in the conjugated diene monomer unit portion in the conjugated diene polymer. It is a numerical value obtained by That is, by proton NMR analysis, in the conjugated diene monomer unit portion in the conjugated diene polymer, the ratio of the peak area of the proton directly bonded to the double bond to the peak area of all protons is measured before and after the cyclization reaction, respectively. Calculate the reduction rate. Specifically, the unsaturated bond reduction rate of the conjugated diene polymer cyclized product can be determined as described below. That is, in the conjugated diene monomer unit portion in the conjugated diene polymer, the total proton peak area before the cyclization reaction is SBT, the peak area of the proton directly bonded to the double bond is SBU, and the total proton after the cyclization reaction Assuming that the peak area is SAT and the peak area of the proton directly bonded to the double bond is SAU, the peak area ratio (SB) of the proton directly bonded to the double bond before the cyclization reaction is expressed by the formula: SB = SBU / SBT The peak area ratio (SA) of protons directly bonded to the double bond after the cyclization reaction is represented by the formula: SA = SAU / SAT. The unsaturated bond reduction rate is obtained by the formula: unsaturated bond reduction rate (%) = 100 × (SB−SA) / SB.

  The unsaturated bond reduction rate of the conjugated diene polymer cyclized product can be adjusted by appropriately selecting the amount of acid catalyst, reaction temperature, reaction time, etc. in the cyclization reaction of the conjugated diene polymer.

  The weight average molecular weight of the conjugated diene polymer cyclized product is usually 1000 to 1,000,000, preferably 50,000 to 500,000, more preferably as a standard polystyrene conversion value measured by gel permeation chromatography. 80,000-300,000. The weight average molecular weight of the conjugated diene polymer cyclized product can be adjusted by appropriately selecting the weight average molecular weight of the conjugated diene polymer subjected to cyclization. When the conjugated diene polymer cyclized product is a conjugated diene-aromatic vinyl monomer block copolymer cyclized product, the weight average molecular weight of the aromatic vinyl polymer block is 1000 to 300,000. Is preferred. By appropriately setting the weight average molecular weight of the conjugated diene polymer cyclized product, the solution viscosity at the time of the cyclization reaction becomes appropriate, and the workability and mechanical strength of the obtained oxygen-absorbing resin composition are improved. It becomes good.

  The content of the gel in the conjugated diene polymer cyclized product is usually 10% by weight or less, preferably 5% by weight or less, and particularly preferably substantially free of gel, as the content of toluene insolubles. . When there is much content of gel, the workability of the resin composition obtained may worsen.

  The glass transition temperature of the conjugated diene polymer cyclized product used for constituting the oxygen-absorbing resin composition is not particularly limited, but is usually 40 ° C. or higher, preferably 50 ° C. or higher, and 55 ° C. More preferably, it is -80 degreeC. The glass transition temperature of the conjugated diene polymer cyclized product is to adjust the reduction rate of unsaturated bond of the conjugated diene polymer cyclized product according to the type of conjugated diene polymer used to obtain the conjugated diene polymer cyclized product. It can be adjusted by.

  The oxygen-absorbing resin composition may be composed of only a conjugated diene polymer cyclized product as an active component for oxygen absorption, but may also comprise other components. For example, a softening agent can be blended in the oxygen-absorbing resin composition for the purpose of adjusting the glass transition temperature of the oxygen-absorbing resin composition as a whole.

  As the softening agent, a liquid material having a glass transition temperature of −30 ° C. or lower is preferably used. The softening agent is preferably compatible with the conjugated diene polymer cyclized product and is preferably incompatible with the matrix resin described later. Specific examples of the softener include hydrocarbon oils such as isoparaffinic oil, naphthenic oil, liquid paraffin; polybutene, polyisobutylene, atactic polypropylene, ethylene-α-olefin copolymer (linear low density polyethylene (LLDPE)) Olefin polymers (low molecular weight) such as linear ultra-low density polyethylene (LVLDPE); hydrogenated conjugated diene polymers (low molecular weight) such as polyisoprene and polybutadiene; styrene-conjugated diene polymers Hydrides (of low molecular weight); fatty acids such as oleic acid, erucic acid, stearic acid, isostearic acid; fatty acid esters. Of these, hydrocarbon oils and / or fatty acids are preferably used, and liquid paraffin and / or erucic acid is particularly preferably used. These softeners may be used alone or in combination of two or more.

  The blending amount of the softening agent is determined according to the type and blending ratio of each component of the oxygen-absorbing resin composition so that the glass transition temperature of the oxygen-absorbing resin composition can be within the target range. The amount is usually 0 to 30% by weight, preferably 1 to 20% by weight, and more preferably 3 to 15% by weight with respect to the entire oxygen-absorbing resin composition.

  The oxygen-absorbing resin composition used in the present invention preferably has a glass transition temperature of −5 ° C. to + 20 ° C. By using an oxygen-absorbing resin composition having such a glass transition temperature, the oxygen-absorbing resin composition is particularly excellent in oxygen absorption performance at room temperature. The glass transition temperature of the oxygen-absorbing resin composition can be easily adjusted by adjusting the compounding ratio of each component in consideration of the glass transition temperature of each component constituting the oxygen-absorbing resin composition. it can.

  You may mix | blend antioxidant with an oxygen absorptive resin composition as needed. By blending an antioxidant, the stability of the oxygen-absorbing resin composition is improved, and handling during processing becomes easy. The content of the antioxidant in the oxygen-absorbing resin composition is not particularly limited, but is usually 5000 ppm by weight or less, preferably 3000 ppm by weight or less, more preferably 2000 ppm by weight or less, and particularly preferably 500 ppm by weight or less. When there is too much content of antioxidant, there exists a possibility of inhibiting the oxygen absorption of an oxygen absorptive resin composition.

  The antioxidant is not particularly limited as long as it is usually used in the field of resin materials and rubber materials. Typical examples of such antioxidants include hindered phenol-based, phosphorus-based and lactone-based antioxidants. These antioxidants can also be used in combination of two or more. Among these, it is preferable to use a phosphorus-based antioxidant. In addition to these antioxidants, an amine light stabilizer (HALS) may be further added.

  In addition to the conjugated diene polymer cyclized product, another resin may be added to the oxygen-absorbing resin composition. For example, when a poly α-olefin resin is blended, the mechanical strength of the resulting composition can be improved. The poly α-olefin resin may be any one of α-olefin homopolymers, copolymers of two or more α-olefins, and copolymers of α-olefins and monomers other than α-olefins. In addition, these (co) polymers may be modified. Specific examples of the poly α-olefin resin include linear low density polyethylene (LLDPE), low density polyethylene (LDPE), medium density polyethylene (MDPE), high density polyethylene (HDPE), metallocene polyethylene, polypropylene, metallocene polypropylene, Examples thereof include polymethylpentene, polybutene, ethylene-propylene random copolymer, ethylene-propylene block copolymer, ethylene-propylene-polybutene-1 copolymer, and ethylene-cycloolefin copolymer. The poly α-olefin resin may be used alone or in combination of two or more.

  In addition, an oxidation catalyst that promotes the oxidation reaction of the conjugated diene polymer cyclized product may be added to the oxygen-absorbing resin composition. Typical examples of the oxidation catalyst include salts of transition metals (transition metal catalysts) such as manganese, iron, cobalt, nickel, copper, rhodium, and ruthenium. Examples of transition metal salt forms include chloride, acetate, stearate, palmitate, ethyl 2-ethylhexanoate, neodecanoate, and naphthoate. However, the conjugated diene polymer cyclized product used for constituting the oxygen-absorbing resin composition in the present invention is a resin that exhibits sufficient oxygen absorption even in the absence of an oxidation catalyst. The addition of a catalyst is not always necessary, and it is preferable that an oxidation catalyst (transition metal catalyst) is not substantially contained in the oxygen-absorbing resin composition in order not to contain a heavy metal component in the container wall of the infusion container.

  You may mix | blend another component with an oxygen absorptive resin composition as needed. Specific examples of other components that can be blended include fillers such as calcium carbonate, alumina and titanium oxide; tackifiers (hydrogenated petroleum resins, hydrogenated terpene resins, castor oil derivatives, sorbitan higher fatty acid esters, low molecular weight polybutenes) ); Surfactant; leveling agent; ultraviolet absorber; light stabilizer; dehydrating agent; pot life extending agent (acetylacetone, methanol, methyl orthoacetate, etc.); repellent improver;

The oxygen absorption rate of the oxygen-absorbing resin composition is not particularly limited, but the oxygen absorption rate at 30 ° C. is preferably 0.01 cc / 100 cm ² · day or more. Here, in the present invention, the oxygen absorption rate of the oxygen-absorbing resin composition is such that the target oxygen-absorbing resin composition is a film having a thickness of 20 μm, and the film has a constant capacity at 30 ° C. under atmospheric pressure. The oxygen capacity (unit: cc) absorbed by the film per unit area (100 cm ² ) per day (24 hours) when placed in dry air. If an oxygen-absorbing resin composition having an oxygen absorption rate that is too low is used, the oxygen-absorbing ability of the resulting composition will be insufficient.

  In the infusion container of the present invention, the oxygen-absorbing resin layer constituting at least a part of the container wall may be composed only of the oxygen-absorbing resin composition as described above. And a composite material of other materials. Specific examples of the case where the oxygen-absorbing resin layer is composed of a composite material with another material include a form in which the oxygen-absorbing resin composition is dispersed in a matrix resin. By using the oxygen-absorbing resin composition dispersed in a matrix resin, an oxygen-absorbing resin layer having oxygen absorbability and excellent mechanical strength and moldability can be obtained.

  The matrix resin is not particularly limited as long as it can disperse the oxygen-absorbing resin composition, but is preferably a thermoplastic resin from the viewpoint of processability. Specific examples of the thermoplastic resin that can be used as the matrix resin include poly α-olefin resins; aromatic vinyl resins such as polystyrene; halogenated vinyl resins such as polyvinyl chloride; polyvinyl alcohol and ethylene-vinyl alcohol copolymers. Polyvinyl alcohol resins such as: fluororesins; acrylic resins such as methacrylic resins; polyamide resins such as polyamide 6 resin, polyamide 66 resin, polyamide 610 resin, polyamide 11 resin, polyamide 12 resin and copolymers thereof; polyethylene terephthalate, poly Examples thereof include polyester resins such as butylene terephthalate and terephthalic acid-cyclohexanedimethanol polyester; polycarbonate resins; polyurethane resins; A matrix resin may be used individually by 1 type, and may use 2 or more types together.

  In constituting the oxygen-absorbing resin layer of the infusion container of the present invention, a resin having an oxygen barrier property (oxygen barrier resin) can be mentioned as a matrix resin particularly preferably used. By making the oxygen-absorbing resin layer into a form in which the oxygen-absorbing resin composition is dispersed in a matrix resin that is an oxygen-barrier resin, the amount of oxygen entering from the outside of the container into the container is extremely small. As a result, the oxygen inside the infusion container can be kept at a very low concentration over a longer period of time.

The oxygen barrier resin is preferably a resin having an oxygen transmission rate of 0.15 to 20 cc / m ² · day · atm (20 μm, 23 ° C., 65% RH). That is, the oxygen permeability of the oxygen barrier resin is 0.15 to 20 cc / m ² · day · atm when a film having a thickness of 20 μm is measured at 23 ° C. and a relative humidity of 65%. It is preferable. Specific examples of the oxygen barrier resin include ethylene-vinyl alcohol copolymer, polyamide resin, polyethylene terephthalate, and polyvinylidene chloride. Among these, it is particularly preferable to use ethylene-vinyl alcohol copolymer. .

  Although ethylene unit content of an ethylene-vinyl alcohol copolymer is not specifically limited, It is preferable that it is 20-50 mol%, and it is especially preferable that it is 25-40 mol%. Degree of saponification of vinyl ester part of ethylene-vinyl alcohol copolymer (monomer unit part having vinyl alcohol structure relative to the sum of monomer unit part having vinyl alcohol structure and monomer unit part having vinyl ester structure) Is not particularly limited, but is preferably 95 mol% or more, more preferably 96 mol% or more, and particularly preferably 99% or more. The ethylene unit content of the ethylene-vinyl alcohol copolymer and the saponification degree of the vinyl ester moiety can be determined by a nuclear magnetic resonance (NMR) method.

  In addition, as the ethylene-vinyl alcohol copolymer, a commercially available ethylene-vinyl alcohol copolymer can also be used, and a general grade ethylene-vinyl alcohol copolymer (for example, trade name “Soarnol DC3203RB”, Nippon Synthetic Chemical Co., Ltd.) may be used, but from the viewpoint of preventing the infusion container from becoming opaque due to sterilization treatment, an anti-whitening grade ethylene-vinyl alcohol copolymer (for example, trade name “Soarnol RB1404BJ”, Japan) It is preferable to use Synthetic Chemical Co., Ltd.

  You may mix | blend another component with a matrix resin. Specific examples of other components that can be blended include heat stabilizers; UV absorbers; colorants; pigments; neutralizers; plasticizers such as phthalates and glycol esters; fillings such as calcium carbonate, alumina, and titanium oxide. Agent: Tackifier (hydrogenated petroleum resin, hydrogenated terpene resin, castor oil derivative, sorbitan higher fatty acid ester, low molecular weight polybutene); surfactant; leveling agent; ultraviolet absorber; light stabilizer; dehydrating agent; Extenders (acetylacetone, methanol, methyl orthoacetate, etc.); repellent improvers;

  A method for dispersing the oxygen-absorbing resin composition in the matrix resin is not particularly limited, and a known method may be adopted, but a melt-kneading method is preferably used from the viewpoint of simplicity of process and cost. When dispersing the oxygen-absorbing resin composition in the matrix resin, it is not necessary to mix each component in advance, and the individual components can be mixed together or in any order to obtain a matrix resin. What is necessary is just to set it as the state which the oxygen absorptive resin composition disperse | distributed in it.

  In the case where the oxygen-absorbing resin composition is dispersed in the matrix resin to form the oxygen-absorbing resin layer, the mixing ratio of the oxygen-absorbing resin composition and the matrix resin is not particularly limited, but the oxygen-absorbing resin composition / The weight ratio of the matrix resin is preferably 5/95 to 50/50, and more preferably 20/80 to 40/60. When the weight ratio of the oxygen-absorbing resin composition / matrix resin is in this range, the function of preventing oxygen from entering inside the container of the obtained oxygen-absorbing resin layer becomes particularly good.

  In the case where the oxygen-absorbing resin composition is used by being dispersed in a matrix resin, a dispersion stabilizer may be used. Specific examples of the dispersion stabilizer include maleic anhydride-modified polypropylene, polyethylene and styrene-diene block copolymer (styrene-isoprene-block copolymer, styrene-butadiene copolymer, styrene-isoprene-styrene block copolymer). Polymer, etc.), and hydrocarbon polymers containing polar groups obtained by modifying styrene polymers such as hydrogenated products thereof.

  The apparatus used when the melt-kneading method is adopted when dispersing the oxygen-absorbing resin composition in the matrix resin is not particularly limited. For example, a continuous intensive mixer, (in the same direction or different directions) kneading type Continuous kneaders such as twin-screw extruders, mixing rolls, and kneaders; batch-type kneaders such as high-speed mixers, Banbury mixers, intensive mixers, and pressure kneaders; An apparatus using a rotating disk having a grinding mechanism; a single-screw extruder provided with a kneading part (Dalmage, CTM, etc.); a simple kneader such as a ribbon blender or a Brabender mixer. The kneading temperature is usually in the range of 50 to 300 ° C, preferably in the range of 170 to 240 ° C.

  The infusion container of the present invention may be composed of a container wall of a single oxygen-absorbing resin layer containing the oxygen-absorbing resin composition as described above. It is preferable that it is comprised by the multilayer container wall formed by laminating | stacking these layers. Layers other than the oxygen-absorbing layer constituting the container wall of the infusion container are not particularly limited, and examples thereof include a heat-sealable resin layer (sealing material layer), an adhesive layer, a gas barrier material layer, and a protective layer. .

  A heat-sealable resin layer that can be used as a layer for constituting a multilayer container wall is composed of a heat-sealable resin, and is melted by heat and bonded to each other (heat-sealed), thereby being attached to an infusion container. It is a layer having a function of forming a space blocked from the outside. Specific examples of heat-sealable resins include homopolymers of ethylene and homopolymers of α-olefins such as propylene, such as low density polyethylene, medium density polyethylene, high density polyethylene, linear low density polyethylene, metallocene polyethylene, Polypropylene, polymethylpentene, polybutene; copolymer of ethylene and α-olefin, such as ethylene-propylene copolymer; α-olefin and vinyl acetate, acrylic acid ester, methacrylic acid ester mainly composed of α-olefin Copolymers such as ethylene-vinyl acetate copolymer, ethylene-ethyl acrylate copolymer, ethylene-methyl methacrylate copolymer, ethylene-acrylic acid copolymer, ethylene-methacrylic acid copolymer Poly α-olefin resins such as polyethylene An acid-modified poly-α-olefin resin obtained by modifying an α-olefin (co) polymer such as len or polypropylene with an unsaturated carboxylic acid such as acrylic acid, methacrylic acid, maleic acid, maleic anhydride, fumaric acid or itaconic acid; ethylene And ionomer resins in which Na ions or Zn ions are allowed to act on a copolymer of methacrylic acid and a mixture thereof; and the like.

  For heat-sealable resins, if necessary, antioxidant; tackifier (hydrogenated petroleum resin, hydrogenated terpene resin, castor oil derivative, sorbitan higher fatty acid ester, low molecular weight polybutene, etc.); antistatic agent; filling Agent; Plasticizer (phthalate ester, glycol ester, etc.); Surfactant; Leveling agent; Heat stabilizer; Weather stabilizer; UV absorber; Light stabilizer; Dehydrator; Pot life extender (acetylacetone, methanol, Repellents; anti-fogging agents; anti-fogging agents; lubricants; reinforcing agents; flame retardants; coupling agents; foaming agents; mold release agents; colorants;

  The adhesive layer is a layer having a function of improving adhesion between the layers by being provided between the layers of different layers. The material for the adhesive layer is not particularly limited as long as it can improve the adhesion between the target layers, but an adhesive resin is suitable. Specific examples of the adhesive resin include homopolymers or copolymers of α-olefins such as low density polyethylene, linear low density polyethylene, medium density polyethylene, high density polyethylene, and polypropylene; ethylene-vinyl acetate copolymer , Ethylene-acrylic acid copolymer, ethylene-ethyl acrylate copolymer, ethylene-methacrylic acid copolymer, ethylene-methyl methacrylate copolymer; polyurethane or polyester one-component or two-component curable Examples thereof include adhesives; carboxylic acid-modified polyolefin resins. Among these, a carboxylic acid-modified polyolefin resin is particularly preferably used as the material for the adhesive layer that improves the adhesion between the oxygen-absorbing resin composition and the heat-sealable resin layer.

  The carboxylic acid-modified polyolefin resin is an olefin polymer or copolymer containing an unsaturated carboxylic acid or an anhydride thereof (such as maleic anhydride) as a copolymerization component, or an unsaturated carboxylic acid or anhydride thereof is an olefin polymer. Or it is a graft copolymer obtained by grafting to a copolymer. Examples of the carboxylic acid-modified polyolefin resin include polyethylene such as low density polyethylene (LDPE), linear low density polyethylene (LLDPE), and very low density polyethylene (VLDPE); polypropylene such as polypropylene and copolymer polypropylene; ethylene And vinyl acetate copolymer, ethylene- (meth) acrylic acid ester (methyl ester or ethyl ester) copolymer;

The gas barrier material layer that can be used as a layer for constituting a multilayer container wall is a layer having a function of preventing permeation of gas such as oxygen from the outside of the infusion container, and is usually an oxygen-absorbing resin layer in the infusion container. It arrange | positions so that it may be located outside. The oxygen permeability of the gas barrier material layer is preferably as small as possible as the workability and cost allow. Specifically, regardless of the film thickness, 100 cc / m ² · atm · day (25 ° C., 90% RH) Or less, particularly preferably 50 cc / m ² · atm · day (25 ° C., 90% RH) or less.

  The material for constituting the gas barrier material layer is not particularly limited as long as it has a low gas permeability such as oxygen and water vapor, but is preferably a resin. Specific examples of the resin used as the gas barrier material layer include polyvinyl alcohol resins such as polyvinyl alcohol and ethylene-vinyl alcohol copolymer; polyester resins such as polyethylene terephthalate and polybutylene terephthalate; MXD nylon (polymetaxylylene adipamide) Polyamide resins such as; vinyl halide resins such as polyvinylidene chloride; and polyacrylonitrile. It is also possible to deposit an inorganic oxide such as aluminum oxide or silicon oxide on these gas barrier material layers. These resins can be appropriately selected in consideration of desired required properties such as gas barrier properties, mechanical properties such as strength, toughness and rigidity, heat resistance, printability, transparency and adhesiveness. These resins may be used alone or in combination of two or more.

  The resin used as the gas barrier material layer includes a heat stabilizer, an ultraviolet absorber, an antioxidant, a colorant, a pigment, a neutralizer, a plasticizer such as a phthalate ester and a glycol ester, a filler, a surfactant, and a leveling agent. Light stabilizers; dehydrating agents such as alkaline earth metal oxides; deodorizers such as activated carbon and zeolite; tackifiers (castor oil derivatives, sorbitan higher fatty acid esters, low molecular weight polybutenes); pot life extenders (acetylacetone, methanol) , Methyl orthoacetate, etc.); repellency improver; other resins (poly α-olefin etc.); Add anti-blocking agent, anti-fogging agent, heat stabilizer, weathering stabilizer, lubricant, antistatic agent, reinforcing agent, flame retardant, coupling agent, foaming agent, mold release agent, etc. as necessary. be able to.

  The protective layer that can be used as a layer for constituting a multilayer container wall is usually disposed so as to be located outside the oxygen-absorbing resin layer or the gas barrier material layer, and functions to protect these layers from heat and external force. It is a layer which has. Although the material of a protective layer is not specifically limited, It is preferable that it is resin. Examples of the resin used for the protective layer include ethylene polymers such as high-density polyethylene; propylene polymers such as propylene homopolymer, propylene-ethylene random copolymer, propylene-ethylene block copolymer; polyamide 6, polyamide 66, and the like. Polyamide; Polyester such as polyethylene terephthalate;

  When the infusion container of the present invention is composed of multilayer container walls, the layer structure is particularly limited as long as it includes an oxygen-absorbing resin layer comprising an oxygen-absorbing resin composition containing a conjugated diene polymer cyclized product. However, it is preferable to have at least an oxygen-absorbing resin layer and a heat-sealable resin layer, and the heat-sealable resin layer, the adhesive layer, and the oxygen-absorbing resin layer are laminated in this order. More preferably, it comprises a three-layer structure. As the container wall of the infusion container of the present invention, a particularly desirable layer structure is, in order from the inner layer of the container, the structure of a heat-sealable resin layer / adhesive layer / oxygen-absorbing resin layer / adhesive layer / protective layer. And heat sealable resin layer / adhesive layer / oxygen-absorbing resin layer / adhesive layer / gas barrier material layer / adhesive layer / protective layer.

  In the infusion container of the present invention, by using an oxygen-absorbing resin composition containing a conjugated diene polymer cyclized product as an oxygen-absorbing resin layer, an oxygen-absorbing agent such as iron powder or an oxidation catalyst such as a transition metal salt is used. A container wall having an oxygen-absorbing resin layer having excellent oxygen-absorbing performance can be provided without the need for blending. Therefore, it is possible to provide an oxygen-absorbing resin layer substantially free of heavy metal components, and as a result, all the layers constituting the container wall can be composed of only layers that do not substantially contain heavy metal components. It becomes. Therefore, in the infusion container of the present invention, the container wall is preferably composed only of a layer that does not substantially contain a heavy metal component. This is because a metal foreign object inspection using a metal detector can be applied to the infusion container, and a highly safe infusion container can be obtained. “Substantially no heavy metal component” means that a heavy metal element is not detected by an inductively coupled plasma optical emission spectrometer having a detection limit of 0.2 μg / g.

  In the infusion container of the present invention, the thickness of the container wall having the oxygen-absorbing resin layer is preferably 100 to 400 μm, and particularly preferably 200 to 300 μm. The thickness of the oxygen-absorbing resin layer constituting the container wall is preferably 20 to 100 μm, and particularly preferably 30 to 60 μm. The thickness of the heat-sealable resin layer is preferably 50 to 200 μm, and particularly preferably 70 to 140 μm. The thickness of the adhesive layer is preferably 3 to 25 μm, and particularly preferably 5 to 15 μm.

  The method for producing the infusion container of the present invention is not particularly limited, but a method of obtaining a film-like or tube-like original fabric having a desired container wall layer structure and forming the original fabric into an infusion container is suitable. It is. When the infusion container is composed of multilayer container walls, these layers may be laminated after obtaining single layers of the respective layers, or the multilayer layers may be directly formed. A single-layer original fabric can be produced by a known method. For example, a film can be obtained by a solution casting method in which a solution obtained by dissolving a resin composition constituting each layer in a solvent is applied and dried on a substantially flat surface. In addition, for example, a resin composition constituting each layer is melt-kneaded with an extruder and then extruded into a predetermined shape through a T-die, a circular die (ring die), etc., so that a T-die method film, a blown film Etc. are obtained. As the extruder, a kneader such as a single screw extruder, a twin screw extruder, or a Banbury mixer can be used. A T-die film can be made into a biaxially stretched film by biaxially stretching it. From the single layer original obtained as described above, a multilayer original can be produced by an extrusion coating method, sandwich lamination, dry lamination or the like.

  A known co-extrusion molding method can be used for the production of a multi-layer raw fabric (film shape, tube shape, etc.), for example, using a multi-layer multiple die using a number of extruders according to the type of material. May be coextruded in the same manner as described above. Examples of the coextrusion molding method include a coextrusion lamination method, a coextrusion sheet molding method, and a coextrusion inflation molding method. If an example in the case of obtaining a tube-shaped original fabric is shown, each material is melt-heated by several extruders by a water-cooled or air-cooled inflation method, and then from a multilayer annular die, for example, 190 to 210 ° C. By extruding at an extrusion temperature and immediately solidifying rapidly with a liquid refrigerant such as cooling water, a tube-shaped raw material can be obtained.

  The method for obtaining the infusion container from the original fabric is also not particularly limited, and the raw fabric is joined to form a space of a desired size for storing the infusion solution blocked from the outside by heat sealing or the like. Accordingly, a member that becomes a mouth may be attached.

  The form of the infusion container of the present invention is particularly limited as long as at least a part of the container wall has an oxygen-absorbing resin layer containing an oxygen-absorbing resin composition containing a conjugated diene polymer cyclized product. Not. For example, it may be a single-chamber infusion container having only one space for storing infusions, or a multi-chamber infusion container having two or more spaces for storing infusions. In the case of a multi-chamber infusion container, a mechanism for communicating the separated spaces as necessary may be provided so that the infusion contained in each space can be mixed in the container. . Specific examples of the mechanism for communicating the separated spaces as necessary include an easy peel-opening seal, a stopper, and a clip. In addition, in the case of a multi-chamber infusion container, a container wall having an oxygen-absorbing resin layer may be arranged only in a space for storing an infusion preparation containing a component that easily changes in quality due to contact with oxygen. You may arrange | position the container wall which has an oxygen absorptive resin layer in this.

  The infusion preparation to be stored in the infusion container of the present invention is not particularly limited, but contains components that are easily altered by contact with oxygen because the oxygen inside the container can be kept at a very low concentration over a long period of time. It is preferably used for storing an infusion preparation. Examples of infusion preparations containing components that are easily altered by contact with oxygen include amino acid infusion preparations containing cysteine, tryptophan, and the like, and fat emulsions containing linoleic acid and the like.

  Hereinafter, the present invention will be described more specifically with reference to examples and comparative examples. In the examples, parts,%, and ppm are based on weight unless otherwise specified.

  Various measurements were performed according to the following methods.

[Weight average molecular weight (Mw) of conjugated diene polymer and cyclized conjugated diene polymer]
Gel permeation chromatography using tetrahydrofuran as an eluting solvent (equipment: HLC8020 (manufactured by Tosoh Corporation), column: TSK gels G2000HXL, G4000HXL and G5000HXL (manufactured by Tosoh Corporation) connected in series, flow rate: 1.0 ml / min. , Temperature 40 ° C., detector: differential refractometer), and calculated as standard polystyrene equivalent molecular weight.

[Reduction rate of unsaturated bond of cyclized conjugated diene polymer]
(I) M.M. A. Golub and J.M. Heller, Can. J. et al. Chem. 41, 937 (1963). And (ii) Y. Tanaka and H.M. Sato, J .; Polym. Sci: Poly. Chem. Ed. 17, 3027 (1979). It was determined by proton NMR measurement with reference to the method described in the literature. In the conjugated diene monomer unit portion in the conjugated diene polymer, the total proton peak area before the cyclization reaction is SBT, the peak area of the proton directly bonded to the double bond is SBU, and the total proton after the cyclization reaction Assuming that the peak area is SAT and the peak area of the proton directly bonded to the double bond is SAU, the peak area ratio (SB) of the proton directly bonded to the double bond before the cyclization reaction is expressed by the formula: SB = SBU / SBT The peak area ratio (SA) of protons directly bonded to the double bond after the cyclization reaction is represented by the formula: SA = SAU / SAT. Therefore, the unsaturated bond reduction rate is obtained by the formula: unsaturated bond reduction rate (%) = 100 × (SB−SA) / SB.

〔Glass-transition temperature〕
Using a differential scanning calorimeter (“EXSTAR 6000 DSC” manufactured by Seiko Instruments Inc.), the temperature was measured at a heating rate of 10 ° C./min in a nitrogen stream.

[Oxygen concentration]
The oxygen concentration inside the container is determined by attaching a sensor chip for nondestructive oxygen measurement (trade name “SP-PSt3-YAU-D5”, manufactured by Taitec Co., Ltd.) using a special adhesive. Measurement was performed using a meter (trade name “FIBOX”, manufactured by Taitec Corporation).

[Presence or absence of heavy metal components]
Using an inductively coupled plasma emission spectrometer (trade name “SPS-5000”, manufactured by SII Nano Technology) with a detection limit of 0.2 μg / g, the internal standard calibration curve method was used to determine the heavy metal components in the sample. The content was measured. The measurement sample was prepared as follows. First, 2 g of a measurement object (film) was weighed in a platinum crucible. Next, the platinum crucible containing the sample was heated with a heater until smoke disappeared, and then heated with a burner to carbonize the sample. Then, each platinum crucible was covered and left in an electric furnace at 550 ° C. for 2 hours. After standing to cool, 0.2 mL of nitric acid and about 6 mL of ultrapure water were added to each platinum crucible and heated with a heater to dissolve ash. This platinum crucible content was made up to a volume of 10 mL using a measuring flask and used as a measurement sample. In addition, two platinum crucibles of the same type were prepared, and the same operation was performed without putting a sample in one of them, and used as a control for measurement.

[Production Example 1]
Polyisoprene (cis-1,4 bond unit content 67.6%, trans-1,4 bond unit cut to 10 mm square in a pressure-resistant reactor equipped with a stirrer, thermometer, reflux condenser and nitrogen gas inlet tube 300 parts of 23.8% content, 3,4-bond unit content 8.6%, weight average molecular weight 248,000) was charged together with 700 parts of toluene. After purging the inside of the reactor with nitrogen, the mixture was heated to 85 ° C. and the polyisoprene was completely dissolved in toluene with stirring, and then p-toluenesulfonic acid (in toluene, so that the water content was 150 ppm or less, The product was reflux-dehydrated 2.4 parts, and the cyclization reaction was carried out while controlling the temperature so as not to exceed 85 ° C. After reacting for 4 hours, 25% aqueous sodium carbonate solution containing 0.83 parts of sodium carbonate was added to stop the reaction. Next, the catalyst residue in the reaction system was removed by washing the oil layer components three times using 300 parts of ion-exchanged water (per once) under the condition of 85 ° C. And a part of toluene was distilled off from the obtained solution, and further toluene was removed by vacuum drying to obtain a solid polyisoprene cyclized product. The weight average molecular weight of the cyclized product of polyisoprene was 229,000, the unsaturated bond reduction rate was 61.4%, and the glass transition temperature was 48 ° C.

  The obtained solid polyisoprene cyclized product was obtained by using a single-screw kneading extruder (40φ, L / D = 25, die diameter 3 mm × 1 hole, manufactured by Ikekai Co., Ltd.), cylinder 1: 140 ° C., cylinder 2 : 150 ° C., Cylinder 3: 160 ° C., Cylinder 4: 170 ° C., Die temperature 170 ° C., Kneading conditions of 25 rpm, and pelletized by a pelletizer to obtain a pelletized polyisoprene cyclized product.

[Production Example 2]
Cyclized product of pellet-shaped polyisoprene obtained in Production Example 1, ethylene-vinyl alcohol copolymer (ethylene unit content 32%, trade name “Soarnol DC3203RB”, manufactured by Nippon Synthetic Chemical Co., Ltd.), liquid paraffin (trade name “ A high-coaxial K-350 "(manufactured by Kaneda) and erucic acid (manufactured by NOF Corporation) at a weight ratio of 23.25 / 70.0 / 1.75 / 5.0, and the biaxial same Directional rotary kneading extruder (trade name “ZE40A (2)”, manufactured by Belstolf, 43φ, L / D = 40, screw length 1600 mm, screw configuration: for liquid filling strong kneading, die: φ3 mm × 3 holes, strand cooling: The mixture was kneaded using water cooling to obtain pellets. The pellet material had a configuration in which an oxygen-absorbing resin composition composed of a cyclized product of polyisoprene, liquid paraffin, and erucic acid was dispersed in an ethylene-vinyl alcohol copolymer. When this material was used as a sample and the glass transition temperature was measured, the glass transition temperature of the oxygen-absorbing resin composition in this material was 14.7 ° C.

[Production Example 3]
Other than having changed the type of ethylene-vinyl alcohol copolymer used from the trade name “Soarnol DC3203RB” to the trade name “Soanol RB1404BJ” (ethylene unit content 32%, manufactured by Nippon Synthetic Chemical Co., Ltd.), which is a whitening prevention grade. Produced pellets in the same manner as in Production Example 2. The pellet material had a configuration in which an oxygen-absorbing resin composition composed of a cyclized product of polyisoprene, liquid paraffin, and erucic acid was dispersed in an ethylene-vinyl alcohol copolymer. When this material was used as a sample and the glass transition temperature was measured, the glass transition temperature of the oxygen-absorbing resin composition in this material was 15.0 ° C.

[Example 1]
The pellet obtained in Production Example 2 was used as the material for the oxygen-absorbing resin layer, using the material for the adhesive layer and the acid-modified poly α-olefin resin (trade name “Modic M545”, manufactured by Mitsubishi Chemical Corporation), and further with a low density. Using the brand name “140HK” (manufactured by Ube Maruzen Polyethylene Co., Ltd.) as the polyethylene resin (LDPE), the LDPE layer (heat-sealable resin layer) / adhesive layer / oxygen-absorbing resin layer is used from the inside by an inflation film forming machine A tube-shaped raw material for an infusion container having a multilayer structure of 3 types and 5 layers of / adhesive layer / LDPE layer (protective layer) was produced. The thickness of each layer was 90/15/40/15/90 μm. When the presence or absence of a heavy metal component was measured using a part of the tubular original fabric as a sample, the heavy metal component was not detected. Next, this tubular raw fabric was cut into a length of 250 mm, and the opening on one end side was heat-sealed to produce a bag-like container. 200 mL of water with a dissolved oxygen content of 3 ppm was put into this container, and the opening on the other end side was also heat-sealed so that air did not enter inside. The container containing the water was sterilized at 115 ° C. for 30 minutes and then allowed to stand at 23 ° C. and a relative humidity of 65%. And 5, 10, 20, 30 days after the start of standing, the dissolved oxygen concentration of the water inside the container was measured. The results are shown in Table 1.

[Example 2]
In place of the pellets obtained in Production Example 2, the pellets obtained in Production Example 3 were used as materials for the oxygen-absorbing resin layer in the same manner as in Example 1, except that a tube-shaped raw material for an infusion container was used. Manufacturing and measuring the dissolved oxygen concentration of water inside the container. The results are shown in Table 1. In addition, when the presence or absence of a heavy metal component was measured for a part of the obtained tube-shaped original fabric as a sample, the heavy metal component was not detected.

[Comparative Example]
In place of the pellets obtained in Production Example 2, except that pellets made only of ethylene-vinyl alcohol copolymer (ethylene unit content 32%, trade name “Soarnol DC3203RB”, manufactured by Nippon Synthetic Chemical Co., Ltd.) were used. In the same manner as in Example 1, a tubular raw fabric for an infusion container was produced, and the dissolved oxygen concentration of water inside the container was measured. The results are shown in Table 1. In addition, when the presence or absence of a heavy metal component was measured for a part of the obtained tube-shaped original fabric as a sample, the heavy metal component was not detected.

  As can be seen from the results shown in Table 1, it was confirmed that in the infusion container of the comparative example having no oxygen-absorbing resin layer, the dissolved oxygen concentration of the water inside the container increased with time from the initial 3 ppm. That is, when an infusion preparation containing a component that easily changes in quality due to contact with oxygen is stored in the infusion container of the comparative example, the infusion preparation deteriorates over time due to dissolved oxygen in the infusion preparation or oxygen entering from the outside of the container. It can be said that. On the other hand, in the infusion container of Example 1 or Example 2 having an oxygen-absorbing resin layer containing an oxygen-absorbing resin composition containing a conjugated diene polymer cyclized product (polyisoprene cyclized product), after standing After 5 days, it was confirmed that the dissolved oxygen concentration of the water inside the container was greatly reduced from the original 3 ppm. This decrease in the dissolved oxygen concentration is considered to be caused by the dissolved oxygen being absorbed by the oxygen-absorbing resin composition in the oxygen-absorbing resin layer. Further, even after standing for 30 days, an increase in the dissolved oxygen concentration was not confirmed, and a low dissolved oxygen concentration was maintained. This is probably because the infusion containers of Example 1 and Example 2 were highly prevented from entering oxygen from the outside of the container. Therefore, in the infusion container of the present invention, it can be said that the oxygen inside the container can be kept at a very low concentration over a long period of time without containing iron powder or a transition metal compound in the container wall.

Claims (4)

  An infusion container constituted by a single-layer or multi-layer container wall, the container wall having an oxygen-absorbing resin layer containing an oxygen-absorbing resin composition containing a conjugated diene polymer cyclized product An infusion container characterized by that.   The infusion container according to claim 1, wherein the oxygen-absorbing resin layer is a layer obtained by dispersing an oxygen-absorbing resin composition containing a conjugated diene polymer cyclized product and a softening agent in a matrix resin.   The infusion container according to claim 1 or 2, wherein the container wall is composed only of a layer substantially not containing a heavy metal component.   The infusion container according to claim 1, wherein the container wall is a multilayer container wall further having a heat-sealable resin layer.