JP2012041314A - 脳腫瘍治療用キット及び脳腫瘍治療方法 - Google Patents
脳腫瘍治療用キット及び脳腫瘍治療方法 Download PDFInfo
- Publication number
- JP2012041314A JP2012041314A JP2010185691A JP2010185691A JP2012041314A JP 2012041314 A JP2012041314 A JP 2012041314A JP 2010185691 A JP2010185691 A JP 2010185691A JP 2010185691 A JP2010185691 A JP 2010185691A JP 2012041314 A JP2012041314 A JP 2012041314A
- Authority
- JP
- Japan
- Prior art keywords
- brain tumor
- tumor treatment
- olanzapine
- cimetidine
- treatment method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000003174 Brain Neoplasms Diseases 0.000 title claims abstract description 144
- 238000011282 treatment Methods 0.000 title claims abstract description 117
- 238000000034 method Methods 0.000 title claims abstract description 62
- 150000001875 compounds Chemical class 0.000 claims abstract description 35
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 18
- 239000003814 drug Substances 0.000 claims abstract description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 69
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 claims description 53
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 claims description 50
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims description 48
- 229940084026 sodium valproate Drugs 0.000 claims description 47
- 229960005017 olanzapine Drugs 0.000 claims description 45
- 229960001380 cimetidine Drugs 0.000 claims description 44
- 208000005017 glioblastoma Diseases 0.000 claims description 43
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 claims description 42
- 229940008015 lithium carbonate Drugs 0.000 claims description 38
- 229910052808 lithium carbonate Inorganic materials 0.000 claims description 38
- 239000004480 active ingredient Substances 0.000 claims description 35
- 239000002246 antineoplastic agent Substances 0.000 claims description 29
- 201000011510 cancer Diseases 0.000 claims description 28
- 230000002354 daily effect Effects 0.000 claims description 24
- 206010018338 Glioma Diseases 0.000 claims description 20
- XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 claims description 19
- ZRCVYEYHRGVLOC-HYARGMPZSA-N gemifloxacin Chemical compound C1C(CN)C(=N/OC)/CN1C(C(=C1)F)=NC2=C1C(=O)C(C(O)=O)=CN2C1CC1 ZRCVYEYHRGVLOC-HYARGMPZSA-N 0.000 claims description 17
- 229960003170 gemifloxacin Drugs 0.000 claims description 17
- 230000000306 recurrent effect Effects 0.000 claims description 17
- 238000007428 craniotomy Methods 0.000 claims description 14
- 208000032612 Glial tumor Diseases 0.000 claims description 13
- 229960004171 hydroxychloroquine Drugs 0.000 claims description 13
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims description 12
- 229940061353 temodar Drugs 0.000 claims description 10
- 230000003203 everyday effect Effects 0.000 claims description 7
- 206010009944 Colon cancer Diseases 0.000 claims description 5
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 4
- 206010017758 gastric cancer Diseases 0.000 claims description 4
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 4
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 4
- 201000011549 stomach cancer Diseases 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 3
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 claims 12
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 abstract description 74
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 abstract description 72
- 230000002401 inhibitory effect Effects 0.000 abstract description 26
- 239000012830 cancer therapeutic Substances 0.000 abstract description 2
- 102000001267 GSK3 Human genes 0.000 abstract 1
- 108060006662 GSK3 Proteins 0.000 abstract 1
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 53
- AQIXAKUUQRKLND-UHFFFAOYSA-N cimetidine Chemical compound N#C/N=C(/NC)NCCSCC=1N=CNC=1C AQIXAKUUQRKLND-UHFFFAOYSA-N 0.000 description 39
- 230000000694 effects Effects 0.000 description 24
- 230000026731 phosphorylation Effects 0.000 description 17
- 238000006366 phosphorylation reaction Methods 0.000 description 17
- 210000001519 tissue Anatomy 0.000 description 14
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 12
- 108010001483 Glycogen Synthase Proteins 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- 208000024891 symptom Diseases 0.000 description 11
- 239000003112 inhibitor Substances 0.000 description 10
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 10
- 239000000523 sample Substances 0.000 description 8
- 206010052428 Wound Diseases 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 7
- YAEMHJKFIIIULI-UHFFFAOYSA-N n-(4-methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2-yl)urea Chemical compound C1=CC(OC)=CC=C1CNC(=O)NC1=NC=C([N+]([O-])=O)S1 YAEMHJKFIIIULI-UHFFFAOYSA-N 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 238000012790 confirmation Methods 0.000 description 6
- 238000001356 surgical procedure Methods 0.000 description 6
- 230000004083 survival effect Effects 0.000 description 6
- 238000001262 western blot Methods 0.000 description 6
- JCSGFHVFHSKIJH-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-4-(1-methyl-3-indolyl)pyrrole-2,5-dione Chemical compound C12=CC=CC=C2N(C)C=C1C(C(NC1=O)=O)=C1C1=CC=C(Cl)C=C1Cl JCSGFHVFHSKIJH-UHFFFAOYSA-N 0.000 description 5
- 108060000903 Beta-catenin Proteins 0.000 description 5
- 102000015735 Beta-catenin Human genes 0.000 description 5
- 230000012292 cell migration Effects 0.000 description 5
- 238000001959 radiotherapy Methods 0.000 description 5
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 5
- 208000007882 Gastritis Diseases 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000000718 duodenal ulcer Diseases 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 230000003902 lesion Effects 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 206010010904 Convulsion Diseases 0.000 description 3
- 238000002965 ELISA Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 208000002927 Hamartoma Diseases 0.000 description 3
- 101001032567 Homo sapiens Glycogen synthase kinase-3 beta Proteins 0.000 description 3
- 206010046274 Upper gastrointestinal haemorrhage Diseases 0.000 description 3
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 235000021152 breakfast Nutrition 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 208000029824 high grade glioma Diseases 0.000 description 3
- 230000002779 inactivation Effects 0.000 description 3
- 201000011614 malignant glioma Diseases 0.000 description 3
- 230000005012 migration Effects 0.000 description 3
- 238000013508 migration Methods 0.000 description 3
- 230000004770 neurodegeneration Effects 0.000 description 3
- 208000015122 neurodegenerative disease Diseases 0.000 description 3
- 210000004498 neuroglial cell Anatomy 0.000 description 3
- 230000000926 neurological effect Effects 0.000 description 3
- 210000002569 neuron Anatomy 0.000 description 3
- 210000004738 parenchymal cell Anatomy 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 206010002243 Anastomotic ulcer Diseases 0.000 description 2
- 206010003571 Astrocytoma Diseases 0.000 description 2
- 201000009030 Carcinoma Diseases 0.000 description 2
- 201000009047 Chordoma Diseases 0.000 description 2
- 208000009798 Craniopharyngioma Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010014967 Ependymoma Diseases 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- 206010061164 Gastric mucosal lesion Diseases 0.000 description 2
- 206010017866 Gastritis haemorrhagic Diseases 0.000 description 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 description 2
- 208000000527 Germinoma Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 2
- 206010026749 Mania Diseases 0.000 description 2
- 208000000172 Medulloblastoma Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 101001032572 Mus musculus Glycogen synthase kinase-3 beta Proteins 0.000 description 2
- 206010029260 Neuroblastoma Diseases 0.000 description 2
- 208000005890 Neuroma Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000008469 Peptic Ulcer Diseases 0.000 description 2
- 206010050487 Pinealoblastoma Diseases 0.000 description 2
- 208000007641 Pinealoma Diseases 0.000 description 2
- 208000007913 Pituitary Neoplasms Diseases 0.000 description 2
- 102000001253 Protein Kinase Human genes 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- 208000007107 Stomach Ulcer Diseases 0.000 description 2
- 206010042220 Stress ulcer Diseases 0.000 description 2
- 206010043276 Teratoma Diseases 0.000 description 2
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000009798 acute exacerbation Effects 0.000 description 2
- 230000037328 acute stress Effects 0.000 description 2
- -1 alkali metal salts Chemical class 0.000 description 2
- 230000003698 anagen phase Effects 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 208000028683 bipolar I disease Diseases 0.000 description 2
- 208000034158 bleeding Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 208000023652 chronic gastritis Diseases 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 208000010932 epithelial neoplasm Diseases 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 201000005917 gastric ulcer Diseases 0.000 description 2
- 201000000052 gastrinoma Diseases 0.000 description 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000011221 initial treatment Methods 0.000 description 2
- 230000031146 intracellular signal transduction Effects 0.000 description 2
- 238000007917 intracranial administration Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 208000000689 peptic esophagitis Diseases 0.000 description 2
- 208000011906 peptic ulcer disease Diseases 0.000 description 2
- 208000028591 pheochromocytoma Diseases 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 230000001124 posttranscriptional effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 108060006633 protein kinase Proteins 0.000 description 2
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 2
- 102200082402 rs751610198 Human genes 0.000 description 2
- 210000002107 sheath cell Anatomy 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 229940106721 tagamet Drugs 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 2
- YYVFPGJOHXZOFT-UHFFFAOYSA-N 2,3-dihydroxypropyl triazete-4-carboxylate Chemical compound C(C(O)CO)OC(=O)C1=NN=N1 YYVFPGJOHXZOFT-UHFFFAOYSA-N 0.000 description 1
- HDHZUDNKLODXFR-UHFFFAOYSA-N 2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethyl hydrogen sulfate Chemical compound ClC1=CC=C2C(NC(C)CCCN(CC)CCOS(O)(=O)=O)=CC=NC2=C1 HDHZUDNKLODXFR-UHFFFAOYSA-N 0.000 description 1
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 208000020925 Bipolar disease Diseases 0.000 description 1
- 238000009010 Bradford assay Methods 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 1
- 101001050288 Homo sapiens Transcription factor Jun Proteins 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 101710135898 Myc proto-oncogene protein Proteins 0.000 description 1
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010061334 Partial seizures Diseases 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 229940122907 Phosphatase inhibitor Drugs 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 108700020978 Proto-Oncogene Proteins 0.000 description 1
- 102000052575 Proto-Oncogene Human genes 0.000 description 1
- 208000037012 Psychomotor seizures Diseases 0.000 description 1
- 241000022563 Rema Species 0.000 description 1
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 1
- 108020004459 Small interfering RNA Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 102100023132 Transcription factor Jun Human genes 0.000 description 1
- 101710150448 Transcriptional regulator Myc Proteins 0.000 description 1
- 102000044159 Ubiquitin Human genes 0.000 description 1
- 108090000848 Ubiquitin Proteins 0.000 description 1
- 108010016200 Zinc Finger Protein GLI1 Proteins 0.000 description 1
- VVBXXVAFSPEIJQ-CVIPOMFBSA-N [(2r)-3-[[(2r)-1-[[(2s,5r,8r,11r,12s,15s,18s,21s)-15-[3-(diaminomethylideneamino)propyl]-21-hydroxy-5-[(4-hydroxyphenyl)methyl]-4,11-dimethyl-2-(2-methylpropyl)-3,6,9,13,16,22-hexaoxo-8-propan-2-yl-10-oxa-1,4,7,14,17-pentazabicyclo[16.3.1]docosan-12-yl]am Chemical compound C([C@@H]1C(=O)N[C@@H](C(=O)O[C@H](C)[C@@H](C(N[C@@H](CCCN=C(N)N)C(=O)N[C@H]2CC[C@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N1C)=O)NC(=O)[C@H](NC(=O)[C@H](O)COS(O)(=O)=O)CC(C)C)C(C)C)C1=CC=C(O)C=C1 VVBXXVAFSPEIJQ-CVIPOMFBSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 206010002224 anaplastic astrocytoma Diseases 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000003430 antimalarial agent Substances 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000003140 astrocytic effect Effects 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000009702 cancer cell proliferation Effects 0.000 description 1
- 230000009400 cancer invasion Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 230000030570 cellular localization Effects 0.000 description 1
- 230000005754 cellular signaling Effects 0.000 description 1
- 210000004720 cerebrum Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002038 chemiluminescence detection Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229940107247 factive Drugs 0.000 description 1
- 239000004503 fine granule Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- JIYMVSQRGZEYAX-CWUUNJJBSA-N gemifloxacin mesylate Chemical compound CS(O)(=O)=O.C1C(CN)C(=N/OC)/CN1C(C(=C1)F)=NC2=C1C(=O)C(C(O)=O)=CN2C1CC1 JIYMVSQRGZEYAX-CWUUNJJBSA-N 0.000 description 1
- 201000003115 germ cell cancer Diseases 0.000 description 1
- 238000000703 high-speed centrifugation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 208000030883 malignant astrocytoma Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000017066 negative regulation of growth Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000003757 neuroblast Anatomy 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000004942 nuclear accumulation Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 201000003113 pineoblastoma Diseases 0.000 description 1
- 206010035059 pineocytoma Diseases 0.000 description 1
- 208000010916 pituitary tumor Diseases 0.000 description 1
- 229940072689 plaquenil Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 208000037821 progressive disease Diseases 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000007363 regulatory process Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- RWVGQQGBQSJDQV-UHFFFAOYSA-M sodium;3-[[4-[(e)-[4-(4-ethoxyanilino)phenyl]-[4-[ethyl-[(3-sulfonatophenyl)methyl]azaniumylidene]-2-methylcyclohexa-2,5-dien-1-ylidene]methyl]-n-ethyl-3-methylanilino]methyl]benzenesulfonate Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C(=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C)C=2C(=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C)C=C1 RWVGQQGBQSJDQV-UHFFFAOYSA-M 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229960004964 temozolomide Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 150000007979 thiazole derivatives Chemical class 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000005748 tumor development Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 229960000604 valproic acid Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010185691A JP2012041314A (ja) | 2010-08-22 | 2010-08-22 | 脳腫瘍治療用キット及び脳腫瘍治療方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010185691A JP2012041314A (ja) | 2010-08-22 | 2010-08-22 | 脳腫瘍治療用キット及び脳腫瘍治療方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012041314A true JP2012041314A (ja) | 2012-03-01 |
| JP2012041314A5 JP2012041314A5 (enrdf_load_stackoverflow) | 2013-09-12 |
Family
ID=45898028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010185691A Pending JP2012041314A (ja) | 2010-08-22 | 2010-08-22 | 脳腫瘍治療用キット及び脳腫瘍治療方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2012041314A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014214126A (ja) * | 2013-04-25 | 2014-11-17 | 学校法人金沢医科大学 | 膵臓癌治療剤 |
| WO2019093379A1 (ja) * | 2017-11-07 | 2019-05-16 | 学校法人自治医科大学 | ミトコンドリアの機能障害の改善剤、及びミトコンドリアの機能障害に起因する疾患又は症状の予防又は治療薬、並びにそれらの用途 |
| KR20190141554A (ko) * | 2018-06-14 | 2019-12-24 | 연세대학교 산학협력단 | 암의 예방 또는 치료용 약학적 조성물 |
| CN115252622A (zh) * | 2022-09-26 | 2022-11-01 | 中日友好医院(中日友好临床医学研究所) | 醛糖还原酶阻化剂及其在制备用于治疗肺癌的药物中的应用 |
-
2010
- 2010-08-22 JP JP2010185691A patent/JP2012041314A/ja active Pending
Non-Patent Citations (2)
| Title |
|---|
| JPN6014032334; 中田光俊: 日本脳神経外科学会総会抄録集（ＣＤ-ＲＯＭ） , 20090914, Ｎｏ．１Ｂ-Ｓ０４-０２ * |
| JPN6014032335; Ｍｉｙａｓｈｉｔａ Ｋ: Ｃｌｉｎ Ｃａｎｃｅｒ Ｒｅｓ Ｖｏｌ．１５, 2009, ｐｐ．８８７-８９７ * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014214126A (ja) * | 2013-04-25 | 2014-11-17 | 学校法人金沢医科大学 | 膵臓癌治療剤 |
| WO2019093379A1 (ja) * | 2017-11-07 | 2019-05-16 | 学校法人自治医科大学 | ミトコンドリアの機能障害の改善剤、及びミトコンドリアの機能障害に起因する疾患又は症状の予防又は治療薬、並びにそれらの用途 |
| US11369615B2 (en) | 2017-11-07 | 2022-06-28 | Jichi Medical University | Agent for improving mitochondrial dysfunction, preventative or therapeutic agent for diseases or symptoms caused by mitochondrial dysfunction, and applications therefor |
| KR20190141554A (ko) * | 2018-06-14 | 2019-12-24 | 연세대학교 산학협력단 | 암의 예방 또는 치료용 약학적 조성물 |
| KR102205656B1 (ko) * | 2018-06-14 | 2021-01-21 | 연세대학교 산학협력단 | 암의 예방 또는 치료용 약학적 조성물 |
| CN115252622A (zh) * | 2022-09-26 | 2022-11-01 | 中日友好医院(中日友好临床医学研究所) | 醛糖还原酶阻化剂及其在制备用于治疗肺癌的药物中的应用 |
| CN115252622B (zh) * | 2022-09-26 | 2023-02-21 | 中日友好医院(中日友好临床医学研究所) | 醛糖还原酶阻化剂及其在制备用于治疗肺癌的药物中的应用 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lim et al. | Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect | |
| Armando et al. | New drugs are not enough-drug repositioning in oncology: An update | |
| Pan et al. | Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis | |
| KR101611824B1 (ko) | 세포 스트레스 반응 조절을 통한 알츠하이머 질환 및 관련 장애의 치료를 위한 신규 치료학적 접근법 | |
| Kalogris et al. | Sanguinarine suppresses basal-like breast cancer growth through dihydrofolate reductase inhibition | |
| EP3038652B1 (en) | Combination of an alk inhibitor and a cdk inhibitor for the treatment of cell proliferative diseases | |
| Lu et al. | Transient receptor potential ankyrin 1 activation within the cardiac myocyte limits ischemia-reperfusion injury in rodents | |
| AU2022404695B2 (en) | New therapeutic combinations for the treatment of progressive fibrosing interstitial lung diseases | |
| Lv et al. | Small-molecule inhibitor targeting protein kinase D: a potential therapeutic strategy | |
| Martinez-Carreres et al. | Cancer: linking powerhouses to suicidal bags | |
| Zhu et al. | CaMK II inhibition attenuates ROS dependent necroptosis in acinar cells and protects against acute pancreatitis in mice | |
| JP2015214579A (ja) | 癌細胞アポトーシス | |
| JP2012041314A (ja) | 脳腫瘍治療用キット及び脳腫瘍治療方法 | |
| AU2025205402A1 (en) | New oral pharmaceutical composition and dose regimen for the therapy of progressive fibrosing interstitial lung diseases | |
| KR101565430B1 (ko) | N-메틸렌나프토[2,1-b]퓨란-2-카보하이드라지드 유도체를 유효성분으로 포함하는 암 예방 또는 치료용 조성물 | |
| Li et al. | The role of mitochondrial dynamin in stroke | |
| Holstein et al. | Renal failure and recovery associated with second-generation Bcr-Abl kinase inhibitors in imatinib-resistant chronic myelogenous leukemia | |
| Xu et al. | Ponatinib-induced ichthyosiform drug eruption: insights into acquired ichthyosis | |
| US11820758B2 (en) | NEK6 kinase inhibitors useful for the treatment of solid tumors | |
| Sampat et al. | Inhibitors of the p21 activated kinases | |
| CA3238805A1 (en) | Nitroxoline for use in the treatment or prevention of a plexiform neurofibroma | |
| KR101532211B1 (ko) | Ampk 억제기능에 기반한 뇌졸중 치료용 약학적 조성물 및 방법 | |
| US20220373535A1 (en) | Methods of identification of synergistic anti-cancer multidrug combinations and uses thereof | |
| CN113648310A (zh) | Gsk872在制备治疗脑出血后神经细胞损伤的药物中的应用 | |
| SULEIMAN | The role of P90 ribosomal S6 kinase and autophagy in sunitinib and ponatinib-induced cardiotoxicity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130729 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130729 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140804 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20141202 |