JP2011524890A5 - - Google Patents
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- Publication number
- JP2011524890A5 JP2011524890A5 JP2011514138A JP2011514138A JP2011524890A5 JP 2011524890 A5 JP2011524890 A5 JP 2011524890A5 JP 2011514138 A JP2011514138 A JP 2011514138A JP 2011514138 A JP2011514138 A JP 2011514138A JP 2011524890 A5 JP2011524890 A5 JP 2011524890A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- pharmaceutical dosage
- outer layer
- form according
- api
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000642 polymer Polymers 0.000 claims description 5
- 239000004971 Cross linker Substances 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims 11
- 239000008186 active pharmaceutical agent Substances 0.000 claims 6
- 210000002784 stomach Anatomy 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 229940072056 alginate Drugs 0.000 claims 2
- 235000010443 alginic acid Nutrition 0.000 claims 2
- 229920000615 alginic acid Polymers 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- 229920003139 Eudragit® L 100 Polymers 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000000112 colonic effect Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 235000019359 magnesium stearate Nutrition 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims 1
- 229960001763 zinc sulfate Drugs 0.000 claims 1
- 229910000368 zinc sulfate Inorganic materials 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA200711000 | 2008-06-19 | ||
| ZA2007/11000 | 2008-06-19 | ||
| PCT/IB2009/005830 WO2009153633A1 (en) | 2008-06-19 | 2009-06-03 | Pharmaceutical dosage form for the site-specific delivery of more than one active pharmaceutical ingredient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011524890A JP2011524890A (ja) | 2011-09-08 |
| JP2011524890A5 true JP2011524890A5 (https=) | 2012-07-19 |
Family
ID=41116789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514138A Pending JP2011524890A (ja) | 2008-06-19 | 2009-06-03 | １を超える活性医薬成分の部位特異的デリバリーのための医薬剤形 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110182987A1 (https=) |
| EP (1) | EP2306984A1 (https=) |
| JP (1) | JP2011524890A (https=) |
| WO (1) | WO2009153633A1 (https=) |
| ZA (1) | ZA200903858B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012070028A1 (en) * | 2010-11-26 | 2012-05-31 | University Of The Witwatersrand, Johannesburg | A pharmaceutical dosage form |
| WO2014043084A1 (en) * | 2012-09-11 | 2014-03-20 | University Of Massachusetts | Polymer-polymer composite nanoassemblies and applications thereof |
| FR2997605B1 (fr) * | 2012-11-08 | 2015-12-11 | Rhodia Operations | Suspensions aqueuses pour compositions agricoles |
| CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| WO2015186108A1 (en) * | 2014-06-05 | 2015-12-10 | University Of The Witwatersrand, Johannesburg | 2 layers tablet oral dosage form for various drug release |
| CA2955229C (en) | 2014-07-17 | 2020-03-10 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| WO2016064873A1 (en) | 2014-10-20 | 2016-04-28 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| GB201511284D0 (en) * | 2015-06-26 | 2015-08-12 | Univ Witwatersrand Jhb | An oral pharmaceutical dosage form for the delivery of a peptide and/or protein |
| EP3610862A1 (en) * | 2018-08-14 | 2020-02-19 | Apillet APS | Novel oral composition |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9002339L (sv) * | 1990-07-04 | 1992-01-05 | Kabi Pharmacia Ab | Terapeutisk komposition och foerfarande foer dess framstaellning |
| GB9710699D0 (en) * | 1997-05-24 | 1997-07-16 | Danbiosyst Uk | Gastro-retentive controlled release system |
| JP2000256216A (ja) * | 1999-03-04 | 2000-09-19 | Meiji Milk Prod Co Ltd | ゲル組成物 |
| CN1285333C (zh) * | 2000-06-07 | 2006-11-22 | 张昊 | 结肠定位释放的口服制剂及其制备方法 |
| MXPA03012041A (es) * | 2001-07-04 | 2004-03-26 | Sun Pharmaceutical Ind Ltd | Sistema de administracion controlada de farmacos de retencion gastrica. |
| WO2003101431A1 (en) * | 2002-06-04 | 2003-12-11 | J.B. Chemicals & Pharmaceuticals Ltd. | Pharmaceutical composition for controlled drug delivery system |
| CN1938335A (zh) * | 2004-01-06 | 2007-03-28 | 西尔布鲁克大学 | 从酸性水溶液中回收脱乙酰壳多糖的简化方法 |
| JP4694145B2 (ja) * | 2004-05-17 | 2011-06-08 | 株式会社 メドレックス | 経口腸溶性製剤 |
| CN101128187A (zh) * | 2005-02-09 | 2008-02-20 | 达沃尔泰拉公司 | 活性剂的结肠递送 |
| CA2661172A1 (en) * | 2006-09-04 | 2008-05-29 | Panacea Biotec Limited | Programmable buoyant delivery technology |
| US20080268045A1 (en) * | 2006-11-09 | 2008-10-30 | Proprius Pharmaceuticals, Inc. | Sustained release methotrexate formulations and methods of use thereof |
-
2009
- 2009-06-01 ZA ZA2009/03858A patent/ZA200903858B/en unknown
- 2009-06-03 WO PCT/IB2009/005830 patent/WO2009153633A1/en not_active Ceased
- 2009-06-03 JP JP2011514138A patent/JP2011524890A/ja active Pending
- 2009-06-03 US US12/999,824 patent/US20110182987A1/en not_active Abandoned
- 2009-06-03 EP EP09766175A patent/EP2306984A1/en not_active Ceased
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