JP2011251952A5 - - Google Patents

Info

Publication number

JP2011251952A5

JP2011251952A5 JP2010128203A JP2010128203A JP2011251952A5 JP 2011251952 A5 JP2011251952 A5 JP 2011251952A5 JP 2010128203 A JP2010128203 A JP 2010128203A JP 2010128203 A JP2010128203 A JP 2010128203A JP 2011251952 A5 JP2011251952 A5 JP 2011251952A5

Authority

JP

Japan

Prior art keywords

hypoglycemic

substance

chitinase3

like4

searching

Prior art date

2010-06-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000126 substance Substances 0.000 claims 16
• 230000002218 hypoglycaemic effect Effects 0.000 claims 13
• 241000255789 Bombyx mori Species 0.000 claims 6
• 238000000034 method Methods 0.000 claims 6
• 210000001124 body fluid Anatomy 0.000 claims 5
• 239000003472 antidiabetic agent Substances 0.000 claims 4
• 238000011156 evaluation Methods 0.000 claims 4
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
• 102100038196 Chitinase-3-like protein 1 Human genes 0.000 claims 3
• 101000883515 Homo sapiens Chitinase-3-like protein 1 Proteins 0.000 claims 3
• 239000008280 blood Substances 0.000 claims 3
• 210000004369 blood Anatomy 0.000 claims 3
• 239000010839 body fluid Substances 0.000 claims 3
• 229940126904 hypoglycaemic agent Drugs 0.000 claims 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
• 102000004877 Insulin Human genes 0.000 claims 2
• 108090001061 Insulin Proteins 0.000 claims 2
• 241001465754 Metazoa Species 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 239000008103 glucose Substances 0.000 claims 2
• 229940125396 insulin Drugs 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000002243 precursor Substances 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 102100037839 Acidic mammalian chitinase Human genes 0.000 claims 1
• 102100037328 Chitotriosidase-1 Human genes 0.000 claims 1
• 101000738085 Homo sapiens Acidic mammalian chitinase Proteins 0.000 claims 1
• 229940125708 antidiabetic agent Drugs 0.000 claims 1
• 108010057052 chitotriosidase Proteins 0.000 claims 1
• 230000007423 decrease Effects 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 235000013376 functional food Nutrition 0.000 claims 1
• 229930182830 galactose Natural products 0.000 claims 1
• 230000010030 glucose lowering effect Effects 0.000 claims 1
• 230000003345 hyperglycaemic effect Effects 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1